Understanding how our cells operate, both normally and when diseased, is essential to developing new ways to overcome disease. These research groups use a variety of approaches to understand how disease occurs, including molecular genetics and bioinformatics, protein structural biology and cell biology techniques. Diseases studied include those of human metabolism, such as gout, cardiovascular disease, and redox signaling regulated diseases, and also infectious diseases, ranging from the bacteria Pseudomonas aeruginosa and Mycobacterium tuberculosis, through to norovirus and Trichoderma fungi.