Research into biomaterials involves the precise engineering of novel materials including molecularly engineered biomaterials (i.e. engineered therapeutics), fabrication of biomaterials into medical devices and technology for biomedical applications (human and animal). In addition to having specific physical, mechanical and biological properties, biomaterials must be biocompatible with healing and tissue regeneration abilities. Research therefore encompasses elements of medicine, materials science and tissue engineering.
Innovative materials can drive the creation of new products (e.g. medical devices and technology) in many life-science sectors. This makes it a crucial pillar for engineered therapeutics. Thus the biomaterials and bioengineering team have sound expertise and experiences in multifaceted applied and pure research and commercial sector partnership. Located within the Centre for Bioengineering and Nanomedicine (Dunedin hub), Faculty of Dentistry, University of Otago, this research focuses on materials/biomaterials (including dental biomaterials) and their relationships with humans.
The main goal of tissue engineering is to create a biocompatible and mechanically suitable architecture that allows cell migration, proliferation and angiogenesis for new tissue formation.
Electrospinning and emerging 3D Melt Electrowriting technology allows the fabrication of porous scaffolds that are in the nanoscale and mimic the natural extracellular matrix of dermal tissue (3D construct skin substitute). The successful creation of a skin tissue scaffold involves the careful selection of polymers in ideal combinations to obtain desired properties. The functionality of the scaffold can then be enhanced by incorporating bio-active cells that provide the correct stimulus for healthy neo-tissue formation.
Bone substitutes and bone ceramics
The aim of the bone graft and bone substitute research activities are to develop a biocompatible, biodegradable bone-graft substitute from reconstituted keratin and bioceramics including newly developed nano-structure hydroxyapatite (nHA) from mussel shells. This material will overcome the disadvantages associated with currently used bone substitutes constructed from typical polymers (e.g. polylactic acid-polyglycolic acid), bioceramics (tri-calcium phosphate, TCP), hydroxyapatite (HA), etc.
Dental biomaterials and bone grafts
Dental pathologies such as caries is one of the most prevalent diseases worldwide. Current therapies are merely cosmetic following removal of the disease and are not designed to produce cellular regeneration. Dental pulp contains stem cells capable of regenerating the dentine in the tooth; consequently, healthy dental pulp is essential for long term tooth survival. The aim of developing novel dental biomaterials and bone graft namely 'No fill No drill” program is to incorporate reconstituted new keratin IFP (rKP) for excellent tissue healing and strength, reconstituted structural collagen (SCP) to provide cell support, and chitosan as an antibacterial substance into a triphasic hybrid biomaterial (3HB) consisting of dental fillers (e.g. DP or MTA). This newly derived 3HB together provide regenerative properties for the pulp-dentin tissues.
Intervertebral Disc (IVD) replacement
The main goal of the intervertebral disc (IVD) tissue engineering is to create a biocompatible and biodegradable functional construct that resolves issues associated with current IVD degeneration treatment. Through this project, we aim to develop a tissue-engineered IVD scaffold that structurally and functionally mimics the native IVD with enhanced cell proliferation and extracellular matrix formation.
Heart valve leaflet
Valvular heart disease (VHD) is a serious health burden affecting morbidity and mortality worldwide. The prevalence of VHD is expected to grow along with the global rise in population. VHD is characterized by the stiffening of the valve leaflets, resulting in stenosis, or regurgitation, and the backflow of the blood. Despite the advances in treatments for VHDs, current treatments are limited by the lack of durability and growth capability of prosthetic valves. Therefore, an alternative approach addressing these issues is required. Tissue engineering is gaining momentum due to its ability to design and fabricate tissue substitutes in vitro for replacement. For heart valve leaflet tissue engineering, either biopolymeric or/and synthetic polymeric biomaterials can be processed via various fabrication techniques such as electrospinning.
Medical gels
A chitosan/dextran(CD)-based, post-surgical gel, Chitogel, has proved itself to be a real winner; and stops bleeding, infection, and dramatically reduces adhesions following ear, nose, and throat surgeries. The two pot mixture sets within a minute to form a firm gel that is slowly degraded in the body. This biocompatible CD gel has been further optimized as an adult stem cell delivery vehicle and bioink for regenerative, wound healing applications.
Drug-eluting medical sutures
The aim of the drug-eluting suture research is to develop a system that incorporates suture materials with active pharmaceutical ingredients (APIs) to achieve target drug release, which can effectively reduce surgical site infection.
Melt extrusion technique allows APIs to be homogeneously dispersed into the cross-section of the sutures. Not only can it potentially enhance solubility of poor water-soluble drug, but also the prolonged drug release can be achieved.
Neural tissue regeneration
The regeneration and repair of both the central nervous system and peripheral nervous system remain crucial challenges in tissue engineering. The underlying reason is that both CNS and PNS have limited capacity for self-regeneration in mammals, and lasting functional deficits are common after disease and injury. Biomaterials, both natural and synthetic in origin, have been continuously identified as having the potential for neural tissue engineering applications including neurite outgrowth, differentiation of human neural stem cells, and nerve gap bridging due to their unique biocompatible and non-immunogenic properties along with substantial regenerative potential and capacity. The aim of this project is to develop an injectable scaffold for CNS using biomaterials and anisotropically conductive material such as carbon nanotubes.
Granted patents
Wound care medical products containing wool keratin, US patent No. 7732574 and European patent No. EP1694370
Biocomposite biomaterials containing biopolymer wool keratin, US patent No. 7767756
Bone void fillers and methods of making the same, US Patent 8142807
Porous keratin construct and method of making the same, US Patent 8124735 and European patent: EP2099437 A2
Porous Keratin constructs, wound healing assembles and method using the same, US patent US/2008 0317826 A1
Nanocomposite negative photoresists for next-generation Lithography, US Patent No. 7049044 B2
Other research projects activities
3D bioprinted regenerative, vascularized constructs for wound healing applications (Associate Professor Azam Ali, Dr Jaydee, Associate Professor Michelle McConnel, ….)
Antimicrobial polymers for dental and medical implants (Associate Professor Azam Ali, Dr Maree Gould, Professor Karl Lyons)
Biocomposite scaffolds for bone-tissue engineering (Associate Professor Azam Ali, Dr Amin Shavandi, Professor George Dias, Dr Maree Gould, Associate Professor Jaydee Cabral)
Biomaterials for treatment of intervertebral discs and spinal bone-tissue regeneration (Associate Professor Azam Ali, Associate Professor Jaydee Cabral, Associate Professor Michelle McConnel)
New Biomaterials from Dairy, Animal and Plant co-products (Associate Professor Azam Ali, Associate Professor Alan Carne, Dr Kate Ryder, Associate Professor Michelle McConnell)
Biometric scaffolds (Associate Professor Azam Ali and Dr Maree Gould)
Dental biomaterials and implants (Associate Professor Azam Ali, Professor Mauro Farella, Professor Karl Lyons, Dr Peter Lee, Dr Joe Anthon)
Drug delivery devices for treating bone infection and inflammation (Associate Professor Azam Ali, Associate Professor Michelle McConnell)
Drug delivery devices for dermal and typical wound care medical devices (Associate Professor Azam Ali, Dr Maree Gould)
Biopolymeric biomaterials, bioformulations for the treatment of sheep footrot (Associate Professor Azam Ali, Professor Aladdin Bekhit, Associate Professor Michelle McConnel)
Wearable sensors as medical devices (Associate Professor Azam Ali, Professor Raechel Laing)
Further projects
Therapeutic Biomaterials for medical devices
Biometric scaffolds
Restorative dental materials
3D biofabrication/printing technology,
Tissue engineering and regenerative medicine, personalized teeth
Implantable medical devices
Microencapsulation, medical implant coatings
Performance testing (including in vitro/in vivo evaluation) of medical devices
Fraser Harrold, Soft and hard tissue mechanics, bone tissue engineering and regeneration
Professor John Reynolds, therapeutic biomaterial and delivery system; neural tissue repair and regeneration
Professor George J. Dias, biomaterials, biobased HA, bone graft and tissue engineering
Professor Mauro Farella , Medical implants/devices, smart brasses
Dr Jithendra Ratnayake, Dental Biomaterials, biobased HA, Dental Implants, bone graft
Dr Dominic Agyei (Department of Food Science), chemical & process engineering, bioactive biomaterials, formulations technology
Dr Sarah Sunderland, Antimicrobial biomaterials and in vitro / in vivo evaluation
External Collaborations
Dr Stewart Collie, Team Leader, AgResearch, Lincoln, Christchurch
Dr Volker Nock, University of Canterbury, New Zealand. Collaboration on Biofabrication of free-standing protein patterning devices for bioengineering applications
Professor Maan Alkaisi (School of Electrical Engineering, University of Canterbury) Collaboration “Soft lithography towards Bionanotechnology for biomedical applications”.
Associate Professor Mark Staiger (School of Mechanical Engineering, University of Canterbury), collaboration on biocomposite scaffolds consisting of proteins-Mg for bone-tissue engineering applications
Associate Professor Frederique Vanholsbeeck (Department of Physics, University of Auckland).
Associate Professor Darren Svirskis, (School of Pharmacy, University of Auckland), Bioformulations Technology, Drug Delivery Devices (DDS); neural tissue regeneration
Dr Paul Rose, Team leader, Callaghan Innovation (ex IRL)
Dr Mathew Cumming (Team Leader, Plant & Food Research), Marine based biomaterials; Bioink preparation and soft-tissue engineering
Professor Robert Love, Dean & Head of Endodontics, Faculty of Dentistry, Griffith University, Australia. students since 2014, scoping joint funding application including HRC/MHARC)
Professor Yusuke Yamauchi, Group Leader, AIBN, Queensland University, Australia
Professor Amar K Mohanty, Premier's Research Chair in Biomaterials Professor, Department of Plant Agriculture & School of Engineering, Director, Bioproducts Discovery & Development Centre (BDDC), University of Guelph; ON, Canada
Professor Xungai Wang, Director, Institute of Frontier Materials, Deakin University, Geelong, Australia
Professor Monique Lacroix, Director, Research Laboratories in Sciences, Canadian Irradiation Centre, INRS-Institut Armand-Frappier, Laval Québec Canada
Professor Dr Saion K Sinha, University Research Scholar University of New Haven, Connecticut, USA
Professor Hai Qiang Wang, Director, Spinal Unit, Department of Orthopaedics, Xijing Hospital Fourth Military Medical University, Xian 710032, China
Professor Ahmed El-Ghannam, Director of Orthopedic Tissue Engineering and Biomaterials Lab., Dept. of Mechanical Engineering and Engineering Science, The University of North Carolina at Charlotte (UNCC), Charlotte, NC 28223
Publications
Chandravarnan, P., Agyei, D., & Ali, A. (2024). The prevalence and concentrations of mycotoxins in rice sourced from markets: A global description. Trends in Food Science & Technology, 104394. Advance online publication. doi: 10.1016/j.tifs.2024.104394
Journal - Research Article
Chandravarnan, P., Agyei, D., & Ali, A. (2024). Innovative strategies to decontaminate ochratoxin A in food and feed. In D. Nagaraju, S. M. Yanjarappa, P. N. Achar & A. M. Vaya (Eds.), Anti-mycotoxin strategies for food and feed. (pp. 59-82). Hoboken, NJ: John Wiley & Sons. doi: 10.1002/9781394160839.ch3
Chapter in Book - Research
Bhowmik, S., Agyei, D., & Ali, A. (2023). Smart hydrogel film potential for active food packaging. Proceedings of the New Zealand Institute of Food Science & Technology (NZIFST) Conference : Food in a Changing World. S02. Retrieved from https://nzifst.org.nz
Conference Contribution - Published proceedings: Abstract
Chandravarnan, P., Agyei, D., & Ali, A. (2023). A bibliometric analysis of peer-reviewed literature on mycotoxins in rice: Trends, patterns, and future directions (2000-2023). Proceedings of the Graduate Research Student Symposium. (pp. 10-11). Retrieved from https://www.otago.ac.nz/graduate-research
Conference Contribution - Published proceedings: Abstract
Bhowmik, S., Ali, A., & Agyei, D. (2023). Chitosan-based smart hydrogel film potential for active food packaging. Proceedings of the Graduate Research Student Symposium. (pp. 8-9). Retrieved from https://www.otago.ac.nz/graduate-research
Conference Contribution - Published proceedings: Abstract
Hoque, M. E., Sarker, M. A., Arif, K., Ali, M. A., & El-Bialy, T. (2023). Antibacterial/antiviral face masks: Processing, characteristics, challenges, and sustainability. MIST International Journal of Science & Technology, 11, 61-79. doi: 10.47981/j.mijst.11(02)2023.421(61-79)
Journal - Research Article
Ali, M. A., & Gould, M. L. (2023). Opportunities, challenges and future of bioceramics. In M. E. Hoque, K. L. Goh & S. Sagadevan (Eds.), Advanced bioceramics: Properties, processing, and applications. (pp. 376-400). Boca Raton, FL: CRC Press. doi: 10.1201/9781003258353-22
Chapter in Book - Research
Thorsnes, Q. S., Turner, P. R., Ali, M. A., & Cabral, J. D. (2023). Integrating fused deposition modeling and melt electrowriting for engineering branched vasculature. Biomedicines, 11, 3139. doi: 10.3390/biomedicines11123139
Journal - Research Article
Rajabi, M., Cabral, J. D., Saunderson, S., Gould, M., & Ali, M. A. (2023). Development and optimisation of hydroxyapatite-polyethylene glycol diacrylate hydrogel inks for 3D printing of bone tissue engineered scaffolds. Biomedical Materials, 18, 065009. doi: 10.1088/1748-605X/acf90a
Journal - Research Article
Tabassum, N., Ahmed, S., Ittisaf, M. M., Rakid-Ul-Haque, M., & Ali, M. A. (2023). A green approach for depolymerization of chitosan: Applications in hydrogels. Cellulose, 30, 8769-8787. doi: 10.1007/s10570-023-05372-9
Journal - Research Article
Thorsnes, Q., Ali, A., & Cabral, J. (2023, July). Novel additive manufacturing techniques for vascular bioscaffolds. Verbal presentation at the Faculty of Dentistry Clinical and Research Excellence Symposium, Dunedin, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Nazmul Islam, G. M., Collie, S., Gould, M., & Ali, M. A. (2023). Two-dimensional carbon material incorporated and PDMS-coated conductive textile yarns for strain sensing. Journal of Coatings Technology & Research. Advance online publication. doi: 10.1007/s11998-023-00784-5
Journal - Research Article
Bhowmik, S., Agyei, D., & Ali, A. (2023). Application of nanochitosan in the preservation of fish and oil. In C. O. Adetunji, D. I. Hefft, J. Jeevanandam & M. K. Danquah (Eds.), Next generation nanochitosan: Applications in animal husbandry, aquaculture and food conservation. (pp. 447-474). London, UK: Academic Press. doi: 10.1016/B978-0-323-85593-8.00031-X
Chapter in Book - Research
Bhowmik, S., Agyei, D., & Ali, A. (2023). Application of nanochitosan in the preservation of meat. In C. O. Adetunji, D. I. Hefft, J. Jeevanandam & M. K. Danquah (Eds.), Next generation nanochitosan: Applications in animal husbandry, aquaculture and food conservation. (pp. 529-560). London, UK: Academic Press. doi: 10.1016/B978-0-323-85593-8.00032-1
Chapter in Book - Research
Rajabi, M., Cabral, J. D., Saunderson, S., & Ali, M. A. (2023). 3D printing of chitooligosaccharide-polyethylene glycol diacrylate hydrogel inks for bone tissue regeneration. Journal of Biomedical Materials Research Part A, 111, 1468-1481. doi: 10.1002/jbm.a.37548
Journal - Research Article
Kabiraz, M. P., Majumdar, P. R., Mahmud, M. M. C., Bhowmik, S., & Ali, A. (2023). Conventional and advanced detection techniques of foodborne pathogens: A comprehensive review. Heliyon, 9, e15482. doi: 10.1016/j.heliyon.2023.e15482
Journal - Research Article
Chen, Z., Hu, Y., Shi, G., Zhuo, H., Ali, M. A., Jamróz, E., … Peng, X. (2023). Advanced flexible materials from nanocellulose. Advanced Functional Materials. Advance online publication. doi: 10.1002/adfm.202214245
Journal - Research Other
Bhuiyan, M. H., Clarkson, A. N., & Ali, M. A. (2023). Optimization of thermoresponsive chitosan/β-glycerophosphate hydrogels for injectable neural tissue engineering application. Colloids & Surfaces B. Advance online publication. doi: 10.1016/j.colsurfb.2023.113193
Journal - Research Article
Ray, P. N., Hoque, M. E., & Ali, M. A. (2023). Sodium alginate nanoadsorbents for wastewater treatment: Synthesis and characterizations. In A. Ahmad, I. Ahmad, T. Kamal, A. M. Asiri & S. Tabassum (Eds.), Sodium alginate-based nanomaterials for wastewater treatment. (pp. 235-271). Amsterdam, Netherlands: Elsevier. doi: 10.1016/B978-0-12-823551-5.00014-8
Chapter in Book - Research
Kang, A., Firth, F. A., Antoun, J., Mei, L., Ali, A., & Farella, M. (2023). Three-dimensional digital assessment of typodont activations. Orthodontics & Craniofacial Research, 26, 285-296. doi: 10.1111/ocr.12611
Journal - Research Article
Cai, M., Ratnayake, J., Cathro, P., Gould, M., & Ali, A. (2022). Investigation of a novel injectable chitosan oligosaccharide-bovine hydroxyapatite hybrid dental biocomposite for the purposes of conservative pulp therapy. Nanomaterials, 12, 3925. doi: 10.3390/nano12213925
Journal - Research Article
Bhowmik, S., Agyei, D., & Ali, A. (2022). Bioactive chitosan and essential oils in sustainable active food packaging: Recent trends, mechanisms, and applications. Food Packaging & Shelf Life, 34, 100962. doi: 10.1016/j.fpsl.2022.100962
Journal - Research Article
Ali, M. A., & Gould, M. L. (2022). Innovativeness and sustainability of polymer nanocomposites. In M. E. Hoque, K. Ramar & A. Sharif (Eds.), Advance polymer nanocomposites: Science, technology and applications. (pp. 515-535). Cambridge, MA: Woodhead Publishing. doi: 10.1016/B978-0-12-824492-0.00001-5
Chapter in Book - Research
Rajabi, M., Ali, A., Cabral, J., & Saunderson, S. (2022, August). Chitooligosaccharide-based inks for 3D printing of hard tissue scaffolds. Poster session presented at the Advances in Microscopy Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.
Conference Contribution - Poster Presentation (not in published proceedings)
Deng, X., Gould, M., & Ali, A. (2022, August). 3D melt extrusion of PCL/PEG/curcumin-loaded PLA microspheres for suture applications. Poster session presented at the Advances in Microscopy Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.
Conference Contribution - Poster Presentation (not in published proceedings)
Paul, S., Ali, A., & Katare, R. (2022, August-September). Investigating the effectiveness of a novel therapeutic to improve diabetic wound healing. Poster session presented at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Conference Contribution - Poster Presentation (not in published proceedings)
Bhuiyan, M. H., Ali, A., & Clarkson, A. (2022, August-September). Novel thermoresponsive hydrogels (NTH) to prevent reactive gliosis after stroke. Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) NZ Annual Scientific Meeting, Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Rajabi, M., Cabral, J., Saunderson, S., & Ali, M. A. (2022). Green synthesis of chitooligosaccharide-PEGDA derivatives through aza-Michael reaction for biomedical applications. Carbohydrate Polymers, 295, 119884. doi: 10.1016/j.carbpol.2022.119884
Journal - Research Article
Deng, X., Gould, M., & Ali, M. A. (2022). A review of current advancements for wound healing: Biomaterial applications and medical devices. Journal of Biomedical Materials Research Part B, 110, 2542-2573. doi: 10.1002/jbm.b.35086
Journal - Research Article
Nazmul Islam, G. M., Ali, M. A., & Collie, S. (2022). Polydopamine treated and PEDOT: PSS coated wash durable conductive textiles for wearable applications. Fibers & Polymers, 23(4), 914-924. doi: 10.1007/s12221-022-3080-0
Journal - Research Article
Chandravarnan, P., Agyei, D., & Ali, A. (2022). Green and sustainable technologies for the decontamination of fungi and mycotoxins in rice: A review. Trends in Food Science & Technology, 124, 278-295. doi: 10.1016/j.tifs.2022.04.020
Journal - Research Article
Yoshida, M., Turner, P. R., McAdam, C. J., Ali, M. A., & Cabral, J. D. (2022). A comparison between β-tricalcium phosphate verse chitosan poly-caprolactone-based 3D melt extruded composite scaffolds. Biopolymers, 113, e23482. doi: 10.1002/bip.23482
Journal - Research Article
Islam, M. T., Laing, R. M., Wilson, C. A., McConnell, M., & Ali, M. A. (2022). Fabrication and characterization of 3-dimensional electrospun poly(vinyl alcohol)/keratin/chitosan nanofibrous scaffold. Carbohydrate Polymers, 275, 118682. doi: 10.1016/j.carbpol.2021.118682
Journal - Research Article
Giteru, S. G., Ali, A., & Oey, I. (2021). Recent progress in understanding fundamental interactions and applications of zein. Food Hydrocolloids, 120, 106948. doi: 10.1016/j.foodhyd.2021.106948
Journal - Research Other
Deng, X., Qasim, M., & Ali, A. (2021). Engineering and polymeric composition of drug-eluting suture: A review. Journal of Biomedical Materials Research Part A, 109, 2065-2081. doi: 10.1002/jbm.a.37194
Journal - Research Other
Ali, M. A., & Bhuiyan, M. H. (2021). Types of biomaterials useful in brain repair. Neurochemistry International, 146, 105034. doi: 10.1016/j.neuint.2021.105034
Journal - Research Article
Tabassum, N., Ahmed, S., & Ali, M. A. (2021). Chitooligosaccharides and their structural-functional effect on hydrogels: A review. Carbohydrate Polymers. doi: 10.1016/j.carbpol.2021.117882
Journal - Research Article
Rajabi, M., McConnell, M., Cabral, J., & Ali, A. (2021). Chitosan hydrogels in 3D printing for biomedical applications. Carbohydrate Polymers, 250, 117768. doi: 10.1016/j.carbpol.2021.117768
Journal - Research Article
Sali, S. S., Gould, M. L., Qasim, M., & Ali, M. A. (2021). Biodegradable methacrylated casein for cardiac tissue engineering applications. Journal of Materials Chemistry B, 9, 1557-1567. doi: 10.1039/d0tb02496a
Journal - Research Article
Yoshida, M., Turner, P. R., Ali, A., & Cabral, J. D. (2021). Three-dimensional melt-electrowritten polycaprolactone/chitosan scaffolds enhance mesenchymal stem cell behavior. ACS Applied Bio Materials, 4, 1319-1329. doi: 10.1021/acsabm.0c01213
Journal - Research Article
Barzegar-Fallah, A., Houlton, J., Barwick, D., Shavandi, A., Ali, M. A., Clarkson, A. N., & Alimoradi, H. (2021). From barriers to bridges: Glycans in naonparenteral nanomedicines. In P. Kesharwani, S. Taurin & K. Greish (Eds.), Theory and applications of nonparenteral nanomedicines. (pp. 467-487). London, UK: Elsevier. doi: 10.1016/B978-0-12-820466-5.00019-3
Chapter in Book - Research
Giteru, S. G., Ali, M. A., & Oey, I. (2021). Elucidating the pH influence on pulsed electric fields-induced self-assembly of chitosan-zein-poly(vinyl alcohol)-polyethylene glycol nanostructured composites. Journal of Colloid & Interface Science, 588, 531-546. doi: 10.1016/j.jcis.2020.12.075
Journal - Research Article
Ali, A., & Gould, M. (2021). Untapped potentials of hazardous nanoarchitecural biopolymers. Journal of Hazardous Materials, 411, 124740. doi: 10.1016/j.jhazmat.2020.124740
Journal - Research Article
Deng, X., Gould, M., & Ali, M. A. (2021). Fabrication and characterisation of melt-extruded chitosan/keratin/PCL/PEG drug-eluting sutures designed for wound healing. Materials Science & Engineering: C, 120, 111696. doi: 10.1016/j.msec.2020.111696
Journal - Research Article
Giteru, S. G., Ali, A., & Oey, I. (2021). Understanding the relationship between rheological characteristics of pulsed electric fields treated chitosan-zein-poly(vinyl alcohol)-polyethylene glycol composite dispersions and the structure-function of their resulting thin-films. Food Hydrocolloids, 113, 106452. doi: 10.1016/j.foodhyd.2020.106452
Journal - Research Article
Nazmul Islam, G. M., Collie, S., Qasim, M., & Ali, M. A. (2020). Highly stretchable and flexible melt spun thermoplastic conductive yarns for smart textiles. Nanomaterials, 10, 2324. doi: 10.3390/nano10122324
Journal - Research Article
Turner, P. R., Yoshida, M., Ali, M. A., & Cabral, J. D. (2020). Melt electrowitten sandwich scaffold technique using Sulforhodamine B to monitor stem cell behavior. Tissue Engineering Part C: Methods, 26(10), 519-527. doi: 10.1089/ten.TEC.2020.0240
Journal - Research Article
Boni, R., Ali, A., Giteru, S. G., Shavandi, A., & Clarkson, A. N. (2020). Silk fibroin nanoscaffolds for neural tissue engineering. Journal of Materials Science: Materials in Medicine, 31, 81. doi: 10.1007/s10856-020-06422-5
Journal - Research Article
Qasim, M., Yasir, M., Ahmad, W., Yoshida, M., Azhar, M., Ali, M. A., Wang, C., & Gould, M. (2020). Early epidemiological and clinical manifestations of COVID-19 in Japan. medRxiv. doi: 10.1101/2020.04.17.20070276
Working Paper; Discussion Paper; Technical Report
Nazmul Islam, G. M., Ali, A., & Collie, S. (2020). Textile sensors for wearable applications: A comprehensive review. Cellulose, 27, 6103-6131. doi: 10.1007/s10570-020-03215-5
Journal - Research Other
Ali, M. A., Rajabi, M., & Sali, S. S. (2020). Additive manufacturing potential for medical devices and technology. Current Opinion in Chemical Engineering, 28, 127-133. doi: 10.1016/j.coche.2020.05.001
Journal - Research Other
Paul, S., Ali, A., & Katare, R. (2020). Molecular complexities underlying the vascular complications of diabetes mellitus: A comprehensive review. Journal of Diabetes & Its Complications, 34, 107613. doi: 10.1016/j.jdiacomp.2020.107613
Journal - Research Article
Ali, A., Gould, M., & Lyons, K. (2020). Development of an organic-inorganic nanostructured hybrid dental biocomposite. Journal of Nanoscience & Nanotechnology, 20(8), 5252-5259. doi: 10.1166/jnn.2020.18527
Journal - Research Article
Giteru, S. G., Ali, M. A., & Oey, I. (2020). Optimisation of pulsed electric fields processing parameters for developing biodegradable films using zein, chitosan and poly(vinyl alcohol). Innovative Food Science & Emerging Technologies, 60, 102287. doi: 10.1016/j.ifset.2020.102287
Journal - Research Article
Ryder, K., Ali, M. A., Billakanti, J., & Carne, A. (2020). Evaluation of dairy co-product containing composite solutions for the formation of bioplastic films. Journal of Polymers & the Environment, 28, 725-736. doi: 10.1007/s10924-019-01635-4
Journal - Research Article
Giteru, S. G., Cridge, B., Oey, I., Ali, A., & Altermann, E. (2020). In-vitro degradation and toxicological assessment of pulsed electric fields crosslinked zein-chitosan-poly(vinyl alcohol) biopolymeric films. Food & Chemical Toxicology, 135, 111048. doi: 10.1016/j.fct.2019.111048
Journal - Research Article
Yoshida, M., Ali, A., & Cabral, J. (2019, August-September). Development and in vitro biocompatibility of 3D printed scaffolds for intervertebral disc tissue engineering. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Hewitt, E., Mros, S., McConnell, M., Cabral, J. D., & Ali, A. (2019). Melt-electrowriting with novel milk protein/PCL biomaterials for skin regeneration. Biomedical Materials, 14, 055013. doi: 10.1088/1748-605X/ab3344
Journal - Research Article
Shavandi, A., & Ali, M. A. (2019). Keratin based thermoplastic biocomposites: A review. Reviews in Environmental Science & Biotechnology, 18(2), 299-316. doi: 10.1007/s11157-019-09497-x
Journal - Research Other
Shavandi, A., & Ali, M. A. (2019). Graft polymerization onto wool fibre for improved functionality. Progress in Organic Coatings, 130, 182-199. doi: 10.1016/j.porgcoat.2019.01.054
Journal - Research Article
Giteru, S. G., Ali, M. A., & Oey, I. (2019). Solvent strength and biopolymer blending effects on physicochemical properties of zein-chitosan-polyvinyl alcohol composite films. Food Hydrocolloids, 87, 270-286. doi: 10.1016/j.foodhyd.2018.08.006
Journal - Research Article
Ali, A. (2018, April). Biomaterials and bioengineering research activities in the UoO, Dunedin. Verbal presentation at the University of Otago Centre for Bioengineering & Nanomedicine Symposium: Biomaterials and Regenerative Medicine, Dunedin, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Boni, R., Ali, A., Shavandi, A., & Clarkson, A. N. (2018). Current and novel polymeric biomaterials for neural tissue engineering. Journal of Biomedical Science, 25, 90. doi: 10.1186/s12929-018-0491-8
Journal - Research Other
Shavandi, A., & Ali, A. (2018). A new adhesive from waste wool protein hydrolysate. Journal of Environmental Chemical Engineering, 6(5), 6700-6706. doi: 10.1016/j.jece.2018.10.022
Journal - Research Article
Giteru, S. G., Oey, I., & Ali, M. A. (2018). Feasibility of using pulsed electric fields to modify biomacromolecules: A review. Trends in Food Science & Technology, 72, 91-113. doi: 10.1016/j.tifs.2017.12.009
Journal - Research Article
Ryder, K., Ali, M. A., Billakanti, J., & Carne, A. (2018). Fundamental characterisation of caseins harvested by dissolved air flotation from dairy wastewater and comparison with skim milk powder. International Dairy Journal, 78, 112-121. doi: 10.1016/j.idairyj.2017.11.007
Journal - Research Article
Ramawarrier, A., Ali, A., Dias, G. J., & Love, R. M. (2017). A novel biocomposite scaffold for regeneration of dental pulp and peri-apical tissues. New Zealand Dental Journal, 113(4), (pp. 54-55). [Abstract]
Conference Contribution - Published proceedings: Abstract
Hashemi, A., de Decker, F., Orcheston-Findlay, L., Ali, M. A., Alkaisi, M. M., & Nock, V. (2017). Enhanced pattern resolution, swelling-behaviour and biocompatibility of bioimprinted casein microdevices. AIP Advances, 7, 115019. doi: 10.1063/1.4991783
Journal - Research Article
Ryder, K., Ali, A., Carne, A., & Billakanti, J. (2017). Novel bionanomaterials from diary proteins. Proceedings of the 8th International Conference on Advanced Materials and Nanotechnology (AMN8). (pp. 394). Retrieved from http://confer.co.nz/amn8/
Conference Contribution - Published proceedings: Abstract
Giteru, S. G., Oey, I., & Ali, M. A. (2017). Effect of pulsed electric field on the rheology and microstructure of biopolymer solutions. Proceedings of the 8th International Conference on Advanced Materials and Nanotechnology (AMN8). (pp. 328). Retrieved from http://confer.co.nz/amn8/
Conference Contribution - Published proceedings: Abstract
Ramawarrier, A., Ali, A., Dias, G. J., & Love, R. M. (2017). A novel biocomposite scaffold potential for regenerative dental therapy. Proceedings of the 8th International Conference on Advanced Materials and Nanotechnology (AMN8). (pp. 296). Retrieved from http://confer.co.nz/amn8/
Conference Contribution - Published proceedings: Abstract
Gangadharan, P. K., Ali, A., Wilson, C. A., & Laing, R. M. (2017). A novel printed conductive fabric for elderly health care. Proceedings of the 8th International Conference on Advanced Materials and Nanotechnology (AMN8). (pp. 207). Retrieved from http://confer.co.nz/amn8/
Conference Contribution - Published proceedings: Abstract
Ali, A., & Gonsalves, K. (2017). A novel biomaterial for direct cell patterning: Potential for bioengineering and regenerative medicine. Proceedings of the 8th International Conference on Advanced Materials and Nanotechnology (AMN8). (pp. 178). Retrieved from http://confer.co.nz/amn8/
Conference Contribution - Published proceedings: Abstract
Hashemi, A., Ali, M. A., Alkaisi, M. M., & Nock, V. (2017). Cross-linked, bioimprinted casein microdevices as biodegradable cell-culture substrates. Proceedings of the 8th International Conference on Advanced Materials and Nanotechnology (AMN8). (pp. 149). Retrieved from http://confer.co.nz/amn8/
Conference Contribution - Published proceedings: Abstract
Ryder, K., Ali, M. A., Carne, A., & Billakanti, J. (2017). The potential use of dairy by-products for the production of non-food biomaterials. Critical Reviews in Environmental Science & Technology, 47(8), 621-642. doi: 10.1080/10643389.2017.1322875
Journal - Research Article
Ali, M. A. (2017, April). Keratin nanofibres potential for wound care applications. Verbal presentation at the Australasian Society for Biomaterials and Tissue Engineering (ASBTE) 25th Annual Conference and the 7th Indo-Australian Conference on Biomaterials, Implants, Tissue Engineering and Regenerative Medicine (BiTERM), Canberra, Australia.
Conference Contribution - Verbal presentation and other Conference outputs
Ajay Sharma, L., Love, R. M., Ali, M. A., Sharma, A., Macari, S., Avadhani, A., & Dias, G. J. (2017). Healing response of rat pulp treated with an injectable keratin hydrogel. Journal of Applied Biomaterials & Functional Materials, 15(3), e244-e250. doi: 10.5301/jabfm.5000346
Journal - Research Article
Giteru, S. G., Oey, I., Ali, M. A., Johnson, S. K., & Fang, Z. (2017). Effect of kafirin-based films incorporating citral and quercetin on storage of fresh chicken fillets. Food Control, 80, 37-44. doi: 10.1016/j.foodcont.2017.04.029
Journal - Research Article
Ramawarrier, A., Ali, A., Dias, G., & Love, R. (2017). Sheep wool keratin based biocomposite scaffold for potential use in regenerative endodontics. Journal of Dental Research, 96(Spec. Iss. A), 0545. Retrieved from http://www.iadr.org
Conference Contribution - Published proceedings: Abstract
Dias, G. J., Mahoney, P., Hung, N. A., Sharma, L. A., Kalita, P., Smith, R. A., … Ali, A. (2017). Osteoconduction in keratin-hydroxyapatite composite bone-graft substitutes. Journal of Biomedical Materials Research Part B, 105(7), 2034-2044. doi: 10.1002/jbm.b.33735
Journal - Research Article
Curline-Wandl, S. A., & Ali, M. A. (2016). Single channel myoelectric control of a 3D printed transradial prosthesis. Cogent Engineering, 3(1), 1245541. doi: 10.1080/23311916.2016.1245541
Journal - Research Article
Ali, M. A., & Shavandi, A. (2016). Medical textiles testing and quality assurance. In L. Wang (Ed.), Performance testing of textiles: Methods, technology and applications. (pp. 129-154). Duxford, UK: Woodhead. doi: 10.1016/B978-0-08-100570-5.00007-4
Chapter in Book - Research
Hu, Z., Ali, A., & Oey, I. (2016). Effect of polyethylene glycol (PEG400) and chitosan and the physical and mechanical properties of zein-containing film. Proceedings of the New Zealand Institute of Food Science & Technology (NZIFST) Conference. (pp. 49-50). Retrieved from http://www.nzifst.org.nz/conference.asp
Conference Contribution - Published proceedings: Abstract
Dias, G., & Ali, A. (2016). Biodegradable bone substitute based on keratin polymer. Frontiers in Bioengineering & Biotechnology, (WBC2016). doi: 10.3389/conf.FBIOE.2016.01.01581
Conference Contribution - Published proceedings: Abstract
Hossain, M. S., Martinac, B., Kim, J. H., Ali, M. A., Mustapic, M., Nakayama, Y., & Horvat, J. (2016). Magnetically triggered smart liposomes. Frontiers in Bioengineering & Biotechnology, (WBC2016). doi: 10.3389/conf.FBIOE.2016.01.01581
Conference Contribution - Published proceedings: Abstract
Shavandi, A., Bekhit, A. E.-D. A., Sun, Z., & Ali, A. (2016). Injectable gel from squid pen chitosan for bone-tissue engineering applications. Frontiers in Bioengineering & Biotechnology, (WBC2016). doi: 10.3389/conf.FBIOE.2016.01.01454
Conference Contribution - Published proceedings: Abstract
Ali, A., Dias, G. J., & Sharma, L. A. (2016). Reconstituted keratin biomaterial potential for pulp-dentine regeneration. Frontiers in Bioengineering & Biotechnology, (WBC2016). doi: 10.3389/conf.FBIOE.2016.01.02139
Conference Contribution - Published proceedings: Abstract
Ali, A., Dias, G. J., & Hossain, S. M. (2016). High-value biomaterials from dairy milk proteins. Frontiers in Bioengineering & Biotechnology, (WBC2016). doi: 10.3389/conf.FBIOE.2016.01.02137
Conference Contribution - Published proceedings: Abstract
Shavandi, A., Bekhit, A. E.-D. A., Sun, Z., & Ali, M. A. (2016). Bio-scaffolds produced from irradiated squid pen and crab chitosan with hydroxyapatite/β-tricalcium phosphate for bone-tissue engineering. International Journal of Biological Macromolecules, 93(Part B), 1446-1456. doi: 10.1016/j.ijbiomac.2016.04.046
Journal - Research Article
Shavandi, A., Bekhit, A. E.-D. A., Sun, Z., & Ali, M. A. (2016). Injectable gel from squid pen chitosan for bone tissue engineering applications. Journal of Sol-Gel Science & Technology, 77(3), 675-687. doi: 10.1007/s10971-015-3899-6
Journal - Research Article
Ajay Sharma, L., Ali, M. A., Love, R. M., Wilson, M. J., & Dias, G. J. (2016). Novel keratin preparation supports growth and differentiation of odontoblast-like cells. International Endodontic Journal, 49(5), 471-482. doi: 10.1111/iej.12476
Journal - Research Article
Shavandi, A., Bekhit, A. E.-D., Sun, Z., & Ali, A. (2015). Chitosan biopolymer from squid pen for biomedical and pharmaceutical applications. In G. I. N. Waterhouse, A. E.-D. A. Bekhit, E. Hewett & D. Sun-Waterhouse (Eds.), Proceedings of the 9th CIGR Section VI International Technical Symposium: Creating Value from Bioresources Through Novel Technologies. (pp. 86). Auckland, New Zealand: 9th CIGR Section VI International Technical Symposium. Retrieved from https://cigr.org
Conference Contribution - Published proceedings: Abstract
Shavandi, A., Bekhit, A. E.-D., Sun, Z., & Ali, A. (2015). Bio-scaffolds produced from irradiated squid pen and crab chitosan with hydroxyapatite/β-tricalcium phosphate for bone tissue engineering. In G. I. N. Waterhouse, A. E.-D. A. Bekhit, E. Hewett & D. Sun-Waterhouse (Eds.), Proceedings of the 9th CIGR Section VI International Technical Symposium: Creating Value from Bioresources Through Novel Technologies. (pp. 85). Auckland, New Zealand: 9th CIGR Section VI International Technical Symposium. Retrieved from https://cigr.org
Conference Contribution - Published proceedings: Abstract
Shavandi, A., Bekhit, A. E.-D. A., Sun, Z., & Ali, A. (2015). A review of synthesis methods, properties and use of hydroxyapatite as a substitute of bone. Journal of Biomimetics, Biomaterials & Biomedical Engineering, 25, 98-117. doi: 10.4028/www.scientific.net/JBBBE.25.98
Journal - Research Article
Shavandi, A., Bekhit, A. A., Bekhit, A. E.-D. A., Sun, Z., & Ali, M. A. (2015). Preparation and characterisation of irradiated crab chitosan and New Zealand Arrow squid pen chitosan. Materials Chemistry & Physics, 167, 295-302. doi: 10.1016/j.matchemphys.2015.10.047
Journal - Research Article
Hashemi, A., Mutreja, I., Alkaisi, M. M., Nock, V., & Ali, M. A. (2015). Fabrication of free-standing casein devices with micro- and nanostructured regular and bioimprinted surface features. Journal of Vacuum Science & Technology B: Microelectronics & Nanometer Structures, 33(6), 06F901. doi: 10.1116/1.4931591
Journal - Research Article
Bekhit, A. E. A., Mros, S., Ali, M. A., & McConnell, M. (2015). Chitosan is a highly effective in vitro antibacterial agent against the strains of bacteria causing footrot, but is not effective in treating stage-four footrot on farm. Proceedings of the New Zealand Society of Animal Production, 75, (pp. 172-174). Retrieved from http://www.nzsap.org/
Conference Contribution - Published proceedings: Full paper
Shavandi, A., Bekhit, A. E.-D. A., Ali, M. A., Sun, Z., & Gould, M. (2015). Development and characterization of hydroxyapatite/β-TCP/chitosan composites for tissue engineering applications. Materials Science & Engineering: C, 56, 481-493. doi: 10.1016/j.msec.2015.07.004
Journal - Research Article
Shavandi, A., Bekhit, A. E.-D. A., Ali, M. A., & Sun, Z. (2015). Bio-mimetic composite scaffold from mussel shells, squid pen and crab chitosan for bone tissue engineering. International Journal of Biological Macromolecules, 80, 445-454. doi: 10.1016/j.ijbiomac.2015.07.012
Journal - Research Article
Shavandi, A., Bekhit, A. E.-D., Sun, Z., & Ali, A. (2015). Waste mussel shells to bone substitute. Proceedings of the 27th National Conference on Microscopy. Retrieved from http://microscopy2015.otago.ac.nz/index.html
Conference Contribution - Published proceedings: Abstract
Shavandi, A., Bekhit, A. E.-D. A., Sun, Z., Ali, A., & Gould, M. (2015). A novel squid pen chitosan/hydroxyapatite/β-tricalcium phosphate composite for bone tissue engineering. Materials Science & Engineering: C, 55, 373-383. doi: 10.1016/j.msec.2015.05.029
Journal - Research Article
Hashemi, A., Tay, D., Mutreja, I., Ali, M. A., Alkaisi, M. M., & Nock, V. (2015, February). Micro- and nano-patterning of freestanding protein films. Verbal presentation at the Seventh International Conference on Advanced Materials & Nanotechnology (AMN-7), Nelson, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Ali, M. A., & Bekhit, A. E. D. (2015, February). Reconstituted keratin nanofibres: Potential for biomedical applications. Verbal presentation at the Seventh International Conference on Advanced Materials & Nanotechnology (AMN-7), Nelson, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Shavandi, A., Bekhit, A. E.-D. A., Ali, A., Sun, Z., & Ratnayake, J. T. (2015). Microwave-assisted synthesis of high purity β-tricalcium phosphate crystalline powder from the waste of Green mussel shells (Perna canaliculus). Powder Technology, 273, 33-39. doi: 10.1016/j.powtec.2014.12.029
Journal - Research Article
Shavandi, A., Bekhit, A. E.-D. A., Ali, A., & Sun, Z. (2015). Synthesis of nano-hydroxyapatite (nHA) from waste mussel shells using a rapid microwave method. Materials Chemistry & Physics, 149-150, 607-616. doi: 10.1016/j.matchemphys.2014.11.016
Journal - Research Article
Ali, A. (2014, May). An innovative biomaterial in medical devices for tissue regeneration. Verbal presentation at the Korea-New Zealand Forum: Bioforum on Repair, Regeneration and Replacement, Seoul, Korea.
Conference Contribution - Verbal presentation and other Conference outputs
Ajay Sharma, L., Ali, A., Wilson, M., & Dias, G. J. (2014, May). The effect of keratin on odontogenic differentiation of odontoblast-like cells. Poster session presented at the International Association for Dental Research (IADR) New Zealand Section Student Poster Competition, Dunedin, New Zealand.
Conference Contribution - Poster Presentation (not in published proceedings)
Ali, A., & Adhami, Z. (2014, December). Superhydrophilic wool: An intelligent material for health and wellbeing applications. Verbal presentation at the 43rd Textile Research Symposium, Christchurch, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Ghosh, A., Ali, A., & Collie, S. (2014, December). Effect of Keratin on mechanical and morphological characteristics of polycaprolactone fibre. Verbal presentation at the 43rd Textile Research Symposium, Christchurch, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Wan, Z.-Y., Song, F., Sun, Z., Chen, Y.-F., Zhang, W.-L., Samartzis, D., … Ali, M.-A., … Luo, Z.-J. (2014). Aberrantly expressed long noncoding RNAs in human intervertebral disc degeneration: A microarray related study. Arthritis Research & Therapy, 16, 465. doi: 10.1186/s13075-014-0465-5
Journal - Research Article
Ali, A. (2014, November). Biomaterials into devices: Understanding the challenges for translating into products or technology. Invited presentation at the Devices for Diagnostics and Drug Delivery (D4) Conference, Dunedin, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Ajay Sharma, L., Ali, A., & Dias, G. (2014). Novel keratin hydrogel for pulp-dentin regeneration: Synthesis and characterization. Journal of Dental Research, 93(Spec Iss B), 1452. Retrieved from http://www.iadr.org
Conference Contribution - Published proceedings: Abstract
Ali, M. A., & Fowler, I. (2013). Self-assembled nanolayers on wood fibres create stain-resistant textiles. Proceedings of the Sixth International Conference on Advanced Materials and Nanotechnology (AMN6). [USB Memory Stick] [Abstract]
Conference Contribution - Published proceedings: Abstract
Ali, M. A., Ghosh, A., & Dias, G. J. (2012, June). Mechanical and biochemical characterisation of bioabsorbable hybrid biomaterials for tissue. Verbal presentation at the 9th World Biomaterials Congress, Chengdu, China.
Conference Contribution - Verbal presentation and other Conference outputs
Kelly, R. J., Marsh, C., Ali, M. A., & Sigurjonsson, G. F. (2012). Porous keratin construct and method of making the same. (8,124,735). United States.
Intellectual Property
Kelly, R. J., Marsh, C., Ali, M. A., & Vorwerk, S. E. (2012). Bone void fillers and methods of making the same. (8,142,807). United States.
Intellectual Property
Ghosh, A., & Ali, M. A. (2012). Studies on physicochemical characteristics of chitosan derivatives with dicarboxylic acids. Journal of Materials Science, 47, 1196-1204. doi: 10.1007/s10853-011-5885-x
Journal - Research Article
Mros, S., Ali, M. A., Ghosh, A., Bekhit, A. E.-D., & McConnell, M. (2012). In vitro evaluation of the antimicrobial effects of chitosan against bacteria involved in ovine footrot. Proceedings of the New Zealand Society of Animal Production, 72, (pp. 196-198). [Full Paper]
Conference Contribution - Published proceedings: Full paper
Ghosh, A., Ali, M. A., Selvanesan, L., & Dias, G. J. (2010). Structure-function characteristics of the biomaterials based on milk-derived proteins. International Journal of Biological Macromolecules, 46, 404-411. doi: 10.1016/j.ijbiomac.2010.02.011
Journal - Research Article
Ghosh, A., Ali, M. A., & Dias, G. J. (2009). Effect of cross-linking on microstructure and physical performance of casein protein. Biomacromolecules, 10(7), 1681-1688. doi: 10.1021/bm801341x
Journal - Research Article
Dias, G. J., Mahoney, P. M., Smith, R. A., Ali, A., & Kelly, R. J. (2006). Biological response of a resorbable keratin-based biopolymer as a bone substitute material. Proceedings of the 28th Australasian Polymer Symposium & Australasian Society for Biomaterials 16th Annual Conference. Queensland, Australia: ASB. [Abstract]
Conference Contribution - Published proceedings: Abstract