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Imaging

Overview

Anthony Butler thumbProfessor Anthony Butler.

The MARS group (Medipix All Resolution System), is a world leader in spectral x-ray technology for molecular imaging of pre-clinical models of disease. The goal of our research is to work with industrial partners to develop a commercial spectral scanner for molecular imaging.

External funding is from a 6-year MBIE (Ministry of Business, Innovation, and Employment) contract ("Taking MARS Spectral CT to Human Imaging"), and a parallel contract with MARS Bioimaging Ltd (MBI). A number health related and collaboration grants provide additional funding to the project. These include the National Health Foundation, the NZ Arthritis Foundation, the New Zealand Royal Society, and the Royal Australian and New Zealand College of Radiologists.

Contact

Professor Anthony Butler
Tel +64 3 378 6359
Mob +64 21 0272 0806
Email anthony.butler@otago.ac.nz

Visit our Partnerships page for more about our partnerships and collaborations.

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Research

MARS Spectral Molecular Imaging

MARS spectral molecular imaging is a new 3D quantitative colour imaging modality. This technology is based on x-ray transmission and has the potential to advance diagnosis and treatment of major health diseases in new ways. The novel features of this scanner are an ability to differentiate and quantify simultaneously several targeted cell types, biomarkers, and drug delivery at the target tissue. It provides molecular imaging at the histological scale by measuring x-ray attenuation of the tissues at different energies (also known as wavelength or colour).

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Our people

Imaging research leader

Professor Anthony Butler, bioengineering and radiology

The team consists of engineers, physicists, computer scientists, biologist, radiologists, and surgeons spread across four universities and several local companies:

  • University of Canterbury (Canterbury)
  • University of Otago (Otago)
  • University of Auckland (Auckland)
  • Lincoln University (Lincoln)
  • MARS Bioimaging Ltd
  • Shamrock Industries
  • Interlink Research Ltd

Lead investigators

  • Dr Christoph Bartneck (HITLab NZ, Canterbury)
  • Dr Stephen Bell (MARS Bioimaging Ltd)
  • Professor Anthony Butler (Bioengineering, Otago, Project leader)
  • Professor Phil Butler (Physics and Astronomy, Canterbury, Project leader)
  • Dr Robert Doesburg (MARS Bioimaging Ltd)
  • Associate Professor Steven Gieseg (Biological Sciences, Canterbury)
  • Mr Brian Goulter (MARS Bioimaging Ltd)
  • Dr Joe Healy (MARS Bioimaging Ltd)
  • Dr David Krofcheck (Physics, Auckland)
  • Dr Stuart Lansley (MARS Bioimaging Ltd)
  • Dr Nanette Schleich (Radiation Therapy, Otago)
  • Dr Michael Walsh (MARS Bioimaging Ltd)
  • Associate Professor Tim Woodfield (Bioengineering, Otago)

Current and recent postdoctoral researchers

  • Dr Marzieh Anjomrouz (MBI, Otago)
  • Dr Ali Atharifard (MBI, Otago)
  • Dr Chris Bateman (Radiology, Otago)
  • Dr Alex Chernoglazov (MBI, Canterbury)
  • Dr Joe Healy (Biological Sciences)
  • Dr Harish Mandalika (MBI, Canterbury)
  • Dr Nadia Mitchell (Radiology, Otago)
  • Dr Mahdieh Moghiseh (Bioengineering Otago)
  • Dr Judy Mohr (Bioengineering, Otago)
  • Dr Raj Panta (Bioengineering Otago)
  • Dr Hannah Prebble (MBI, Canterbury)
  • Dr Aamir Raja (Bioengineering, Otago)
  • Dr Niels de Ruiter (Bioengineering Otago and HITLab Canterbury)

A large number of postgraduate students have worked alongside Imaging researchers to achieve their qualifications.
Visit our Imaging students page

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Publications

Lau, L. C. M., Lee, W. Y. W., Butler, A. P. H., Chernoglazov, A. I., Chung, K. Y., Ho, K. K. W., … Butler, P. H., & Yung, P. S. H. (2021). Multi-energy spectral photon-counting computed tomography (MARS) for detection of arthroplasty implant failure. Scientific Reports, 11, 1554. doi: 10.1038/s41598-020-80463-2

Ostadhossein, F., Tripathi, I., Benig, L., LoBato, D., Moghiseh, M., Lowe, C., Aamir, R., Butler, A., Panta, R., Anjomrouz, M., … Pan, D. (2020). Multi-"color" delineation of bone microdamages using ligand-directed sub-5 nm hafnia nanodots and photon counting CT imaging. Advanced Functional Materials, 30, 1904936. doi: 10.1002/adfm.201904936

Marfo, E., Anderson, N. G., Butler, A. P. H., Schleich, N., Carbonez, P., Damet, J., Lowe, C., Healy, J., … Moghiseh, M., MARS Collaboration, & Raja, A. Y. (2020). Assessment of material identification errors, image quality and radiation doses using small animal spectral photon-counting CT. IEEE Transactions on Radiation & Plasma Medical Sciences. Advance online publication. doi: 10.1109/TRPMS.2020.3003260

Kanithi, P., de Ruiter, N. J. A., Amma, M. R., Lindeman, R. W., Butler, A. P. H., Butler, P. H., … Adebileje, S. A., … Asghariomabad, F., … Bamford, B., … Carbonez, P., … Clark, J. A., … Crighton, J. S., Dahal, S., Damet, J., … Gieseg, S. P., … Gurney, S. J., Healy, J. L., … Lowe, C., Marfo, E., Matanaghi, A., Moghiseh, M., … Panta, R. K., … Raja, A. Y., Renaud, P. F., … Schleich, N., … Sheeja, J. S., … Walker, E. P., … Younger, W. R. (2020). Interactive image segmentation of MARS datasets using bag of features. IEEE Transactions on Radiation & Plasma Medical Sciences. Advance online publication. doi: 10.1109/TRPMS.2020.3030045

Simard, M., Kumar Panta, R., Bell, S. T., Butler, A. P. H., & Bouchard, H. (2020). Quantitative imaging performance of MARS spectral photon-counting CT for radiotherapy. Medical Physics, 47(8), 3423-3434. doi: 10.1002/mp.14204

Chapter in Book - Research

Kumar, P., Singh, B., Chaudhari, P., Jose, J., Butler, A., Prebble, H., Moghiseh, M., and the MARS Collaboration. (2019). Preclinical non-invasive imaging in cancer research and drug discovery: An overview. In K. Bose & P. Chaudhari (Eds.), Unravelling cancer signaling pathways: A multidisciplinary approach. (pp. 419-469). Singapore: Springer Nature. doi: 10.1007/978-981-32-9816-3_17

Walsh, M. F., Aamir, R., Panta, R. K., Rajendran, K., Anderson, N. G., Butler, A. P. H., & Butler, P. H. (2015). Spectral molecular CT with photon-counting detectors. In S. Awadalla (Ed.), Solid-state radiation detectors: Technology and applications. (pp. 195-219). Boca Raton, FL: CRC Press.

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Chapter in Book - Other

Butler, A. (2013). Centre for Bioengineering. In P. Joyce, G. Nicholls, K. Thomas & T. Wilkinson (Eds.), The Christchurch experience: 40 years of research and teaching. (pp. 109-112). Christchurch, New Zealand: University of Otago.

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Journal - Research Article

Lau, L. C. M., Lee, W. Y. W., Butler, A. P. H., Chernoglazov, A. I., Chung, K. Y., Ho, K. K. W., … Butler, P. H., & Yung, P. S. H. (2021). Multi-energy spectral photon-counting computed tomography (MARS) for detection of arthroplasty implant failure. Scientific Reports, 11, 1554. doi: 10.1038/s41598-020-80463-2

Ostadhossein, F., Tripathi, I., Benig, L., LoBato, D., Moghiseh, M., Lowe, C., Aamir, R., Butler, A., Panta, R., Anjomrouz, M., … Pan, D. (2020). Multi-"color" delineation of bone microdamages using ligand-directed sub-5 nm hafnia nanodots and photon counting CT imaging. Advanced Functional Materials, 30, 1904936. doi: 10.1002/adfm.201904936

Simard, M., Kumar Panta, R., Bell, S. T., Butler, A. P. H., & Bouchard, H. (2020). Quantitative imaging performance of MARS spectral photon-counting CT for radiotherapy. Medical Physics, 47(8), 3423-3434. doi: 10.1002/mp.14204

Kanithi, P., de Ruiter, N. J. A., Amma, M. R., Lindeman, R. W., Butler, A. P. H., Butler, P. H., … Adebileje, S. A., … Asghariomabad, F., … Bamford, B., … Carbonez, P., … Clark, J. A., … Crighton, J. S., Dahal, S., Damet, J., … Gieseg, S. P., … Gurney, S. J., Healy, J. L., … Lowe, C., Marfo, E., Matanaghi, A., Moghiseh, M., … Panta, R. K., … Raja, A. Y., Renaud, P. F., … Schleich, N., … Sheeja, J. S., … Walker, E. P., … Younger, W. R. (2020). Interactive image segmentation of MARS datasets using bag of features. IEEE Transactions on Radiation & Plasma Medical Sciences. Advance online publication. doi: 10.1109/TRPMS.2020.3030045

Marfo, E., Anderson, N. G., Butler, A. P. H., Schleich, N., Carbonez, P., Damet, J., Lowe, C., Healy, J., … Moghiseh, M., MARS Collaboration, & Raja, A. Y. (2020). Assessment of material identification errors, image quality and radiation doses using small animal spectral photon-counting CT. IEEE Transactions on Radiation & Plasma Medical Sciences. Advance online publication. doi: 10.1109/TRPMS.2020.3003260

Bateman, C. J., Knight, D., Brandwacht, B., McMahon, J., Healy, J., Panta, R., Aamir, R., Rajendran, K., Moghiseh, M., Ramyar, M., … de Ruiter, N., … Shamshad, M., Anjomrouz, M., Atharifard, A., … Bheesette, S., … Anderson, N. G., Gieseg, S. P., Woodfield, T., Renaud, P. F., Butler, A. P. H., & Butler, P. H. (2018). MARS-MD: Rejection based image domain material decomposition. Journal of Instrumentation, 13, P05020. doi: 10.1088/1748-0221/13/05/p05020

Anjomrouz, M., Shamshad, M., Panta, R. K., Vanden Broeke, L., Schleich, N., Atharifard, A., Raja, A., Bheesette, S., Walsh, M. F., Goulter, B. P., … Bateman, C. J., Butler, A. P. H., & Butler, P. H. (2018). Beam profile assessment in spectral CT scanners. Journal of Applied Clinical Medical Physics, 19(2), 287-297. doi: 10.1002/acm2.12260

Panta, R. K., Bell, S. T., Healy, J. L., Aamir, R., Bateman, C. J., Moghiseh, M., Butler, A. P. H., & Anderson, N. G. (2018). Element-specific spectral imaging of multiple contrast agents: A phantom study. Journal of Instrumentation, 13, T02001. doi: 10.1088/1748-0221/13/02/T02001

Moghiseh, M., Lowe, C., Lewis, J., Kumar, D., Butler, A., Anderson, N., & Raja, A. (2018). Spectral photon-counting molecular imaging for quantification of monoclonal antibody-conjugated gold nanoparticles targeted to lymphoma and breast cancer: An in vitro study. Contrast Media & Molecular Imaging, 2018, 2136840. doi: 10.1155/2018/2136840

Prebble, H., Cross, S., Marks, E., Healy, J. L., Searle, E., Aamir, R., Butler, A., Roake, J., Hock, B., Anderson, N., & Gieseg, S. P. (2018). Induced macrophage activation in live excised atherosclerotic plaque. Immunobiology, 223(8-9), 526-535. doi: 10.1016/j.imbio.2018.03.002

Mandalika, V. B. H., Chernoglazov, A. I., Billinghurst, M., Bartneck, C., Hurrell, M. A., de Ruiter, N., Butler, A. P. H., & Butler, P. H. (2018). A hybrid 2D/3D user interface for radiological diagnosis. Journal of Digital Imaging, 31(1), 56-73. doi: 10.1007/s10278-017-0002-6

Raja, A. Y., Moghiseh, M., Bateman, C. J., de Ruiter, N., Schon, B., Schleich, N., Woodfield, T. B. F., Butler, A. P. H., & Anderson, N. G. (2018). Measuring identification and quantification errors in spectral CT material decomposition. Applied Sciences, 8(3), 467. doi: 10.3390/app8030467

Lu, G., Marsh, S., Damet, J., Carbonez, P., Laban, J., Bateman, C., Butler, A., & Butler, P. (2017). Dosimetry in MARS spectral CT: TOPAS Monte Carlo simulations and ion chamber measurements. Australasian Physical & Engineering Sciences in Medicine, 40(2), 297-303. doi: 10.1007/s13246-017-0532-8

Shamshad, M., Anjomrouz, M., Smithies, D. J., Largeau, A., Lu, G., Atharifard, A., … Aamir, R., Panta, R. K., Walsh, M. F., Goulter, B. P., Healy, J. L., Bheesette, S., … Bateman, C. J., Butler, A. P. H., & Butler, P. H. (2017). Semi-analytic off-axis X-ray source model. Journal of Instrumentation, 12, P10013. doi: 10.1088/1748-0221/12/10/p10013

Rajendran, K., Löbker, C., Schon, B. S., Bateman, C. J., Younis, R. A., de Ruiter, N. J. A., … Ramyar, M., Hooper, G. J., Butler, A. P. H., Woodfield, T. B. F., & Anderson, N. G. (2017). Quantitative imaging of excised osteoarthritic cartilage using spectral CT. European Radiology, 27(1), 384-392. doi: 10.1007/s00330-016-4374-7

Moghiseh, M., Aamir, R., Panta, R. K., de Ruiter, N., Chernoglazov, A., Healy, J. L., Butler, A. P. H., & Anderson, N. G. (2016). Discrimination of multiple high-Z materials by multi-energy spectral CT: A phantom study. JSM Biomedical Imaging Data Papers, 3(1), 1007.

Gregan, J., Balasingham, A., & Butler, A. (2016). Radiology in the Christchurch earthquake of 22 February 2011: Challenges, interim processes and clinical priorities. Journal of Medical Imaging & Radiation Oncology, 60(2), 172-181. doi: 10.1111/1754-9485.12315

Foo, E., McDonald, R., Savage, E., Floyd, R., Butler, A., Rumball-Smith, A., & Connor, S. (2015). Mobile task management tool that improves workflow of an acute general surgical service. ANZ Journal of Surgery, 85(10), 760-765. doi: 10.1111/ans.12988

Panta, R. K., Walsh, M. F., Bell, S. T., Anderson, N. G., Butler, A. P., & Butler, P. H. (2015). Energy calibration of the pixels of spectral X-ray detectors. IEEE Transactions on Medical Imaging, 34(3), 697-706. doi: 10.1109/TMI.2014.2337881

Butler, A., Butler, P., Bell, S., Chelkov, G. A., Dedovich, D. V., Demichev, M. A., … Zhemchugov, A. S. (2015). Measurement of the energy resolution and calibration of hybrid pixel detectors with GaAs:Cr sensor and Timepix readout chip. Physics of Particles & Nuclei Letters, 12(1), 59-73. doi: 10.1134/S1547477115010021

Rajendran, K., Walsh, M. F., de Ruiter, N. J. A., Chernoglazov, A. I., Panta, R. K., Butler, A. P. H., … Anderson, N. G., Woodfield, T. B. F., Tredinnick, S. J., … Bateman, C. J., Aamir, R., … Smithies, D. J., Mohr, J. L., … Ronaldson, J. P., … Atharifard, A., … Schleich, N., & Billinghurst, M. (2014). Reducing beam hardening effects and metal artefacts in spectral CT using Medipix3RX. Journal of Instrumentation, 9, P03015. doi: 10.1088/1748-0221/9/03/P03015

Opie, A. M. T., Bennett, J. R., Walsh, M., Rajendran, K., Yu, H., Xu, Q., Butler, A., … Wang, G. (2014). Study of scan protocol for exposure reduction in hybrid spectral micro-CT. Scanning, 36(4), 444-455. doi: 10.1002/sca.21140

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