Dr Andrew Bahn
Position | Senior Lecturer |
---|---|
Department | Department of Physiology |
Qualifications | PhD |
Research summary | Organic anion transport especially urate and tryptophan metabolite transport |
Research
The aim of Dr Bhan’s research is to identify how high (diabetes, prostate cancer and gout) or low (neurodegenerative diseases) urate plasma levels contribute to the above diseases.Publications
Ashley, Z., Futi, T., Van Hout, I., Coffey, S., Schwenke, D. O., Bahn, A., & Lamberts, R. R. (2022). Cardiac fibrosis in right atrial tissue is not different in male Pasifika and Pākehā cardiac surgery patients in Aotearoa. Pacific Journal of Medical Sciences, 22(2), 11-30.
Reily-Bell, M., Bahn, A., & Katare, R. (2022). Reactive oxygen species-mediated diabetic heart disease: Mechanisms and therapies. Antioxidants & Redox Signaling, 36(10-12), 608-630. doi: 10.1089/ars.2021.0098
Purvis, N., Kumari, S., Chandrasekera, D., Bellae Papannarao, J., Gandhi, S., van Hout, I., Coffey, S., Bunton, R., Sugunesegran, R., Parry, D., Davis, P., Williams, M. J. A., Bahn, A., & Katare, R. (2021). Diabetes induces dysregulation of microRNAs associated with survival, proliferation and self-renewal in cardiac progenitor cells. Diabetologia, 64, 1422-1435. doi: 10.1007/s00125-021-05405-7
Cook, R. F., Bussey, C. T., Fomison-Nurse, I. C., Hughes, G., Bahn, A., Cragg, P. A., & Lamberts, R. R. (2019). β2-adrenoceptors indirectly support impaired β1-adrenoceptor responsiveness in the isolated type 2 diabetic rat heart. Experimental Physiology, 104, 808-818. doi: 10.1113/EP087437
Bussey, C. T., Thaung, H. P. A., Hughes, G., Bahn, A., & Lamberts, R. R. (2018). Cardiac β-adrenergic responsiveness of obese Zucker rats: The role of AMPK. Experimental Physiology, 103(8), 1067-1075. doi: 10.1113/ep087054
Bahn, A. (2017). Water, electrolytes, and acid-base balance. In J. Mann & A. S. Truswell (Eds.), Essentials of human nutrition. (5th ed.) (pp. 113-130). Oxford University Press.
Chapter in Book - Research
Ashley, Z., Futi, T., Van Hout, I., Coffey, S., Schwenke, D. O., Bahn, A., & Lamberts, R. R. (2022). Cardiac fibrosis in right atrial tissue is not different in male Pasifika and Pākehā cardiac surgery patients in Aotearoa. Pacific Journal of Medical Sciences, 22(2), 11-30.
Journal - Research Article
Purvis, N., Kumari, S., Chandrasekera, D., Bellae Papannarao, J., Gandhi, S., van Hout, I., Coffey, S., Bunton, R., Sugunesegran, R., Parry, D., Davis, P., Williams, M. J. A., Bahn, A., & Katare, R. (2021). Diabetes induces dysregulation of microRNAs associated with survival, proliferation and self-renewal in cardiac progenitor cells. Diabetologia, 64, 1422-1435. doi: 10.1007/s00125-021-05405-7
Journal - Research Article
Cook, R. F., Bussey, C. T., Fomison-Nurse, I. C., Hughes, G., Bahn, A., Cragg, P. A., & Lamberts, R. R. (2019). β2-adrenoceptors indirectly support impaired β1-adrenoceptor responsiveness in the isolated type 2 diabetic rat heart. Experimental Physiology, 104, 808-818. doi: 10.1113/EP087437
Journal - Research Article
Bussey, C. T., Thaung, H. P. A., Hughes, G., Bahn, A., & Lamberts, R. R. (2018). Cardiac β-adrenergic responsiveness of obese Zucker rats: The role of AMPK. Experimental Physiology, 103(8), 1067-1075. doi: 10.1113/ep087054
Journal - Research Article
Sangkop, F., Singh, G., Rodrigues, E., Gold, E., & Bahn, A. (2016). Uric acid: A modulator of prostate cells and activin sensitivity. Molecular & Cellular Biochemistry, 414(1-2), 187-199. doi: 10.1007/s11010-016-2671-8
Journal - Research Article
Purvis, N., Bahn, A., & Katare, R. (2015). The role of microRNAs in cardiac stem cells. Stem Cells International, 2015(2015), 194894. doi: 10.1155/2015/194894
Journal - Research Article
Thaung, H. P. A., Baldi, J. C., Wang, H.-Y., Hughes, G., Cook, R. F., Bussey, C. T., Sheard, P. W., Bahn, A., Jones, P. P., Schwenke, D. O., & Lamberts, R. R. (2015). Increased efferent cardiac sympathetic nerve activity and defective intrinsic heart rate regulation in type 2 diabetes. Diabetes, 64(8), 2944-2956. doi: 10.2337/db14-0955
Journal - Research Article
Thaung, H. P. A., Yao, Y., Bussey, C. T., Hughes, G., Jones, P. P., Bahn, A., Sammut, I. A., & Lamberts, R. R. (2015). Chronic bilateral renal denervation reduces cardiac hypertrophic remodelling but not β-adrenergic responsiveness in hypertensive type 1 diabetic rats. Experimental Physiology, 100(6), 628-639. doi: 10.1113/EP085021
Journal - Research Article
Knake, C., Stamp, L., & Bahn, A. (2014). Molecular mechanism of an adverse drug-drug interaction of allopurinol and furosemide in gout treatment. Biochemical & Biophysical Research Communications, 452, 157-162. doi: 10.1016/j.bbrc.2014.08.068
Journal - Research Article
Lamberts, R. R., Lingam, S. J., Wang, H.-Y., Bollen, I. A. E., Hughes, G., Galvin, I. F., Bunton, R. W., Bahn, A., Katare, R., Baldi, J. C., Williams, M. J. A., Saxena, P., Coffey, S., & Jones, P. P. (2014). Impaired relaxation despite upregulated calcium-handling protein atrial myocardium from type 2 diabetic patients with preserved ejection fraction. Cardiovascular Diabetology, 13, 72. doi: 10.1186/1475-2840-13-72
Journal - Research Article
Dinour, D., Bahn, A., Ganon, L., Ron, R., Geifman-Holtzman, O., Knecht, A., … Holtzman, E. J. (2011). URAT1 mutations cause renal hypouricemia type 1 in Iraqi Jews. Nephrology Dialysis Transplantation, 26(7), 2175-2181. doi: 10.1093/ndt/gfq722
Journal - Research Article
Rödiger, M., Zhang, X., Ugele, B., Gersdorff, N., Wright, S. H., Burckhardt, G., & Bahn, A. (2010). Organic anion transporter 3 (OAT3) and renal transport of the metal chelator 2,3-dimercapto-1-propanesulfonic acid (DMPS). Canadian Journal of Physiology & Pharmacology, 88(2), 141-146. doi: 10.1139/Y09-123
Journal - Research Article
Bakhiya, N., Arlt, V. M., Bahn, A., Burckhardt, G., Phillips, D. H., & Glatt, H. (2009). Molecular evidence for an involvement of organic anion transporters (OATs) in aristolochic acid nephropathy. Toxicology, 264(1-2), 74-79. doi: 10.1016/j.tox.2009.07.014
Journal - Research Article
Bahn, A., Hagos, Y., Reuter, S., Balen, D., Brzica, H., Krick, W., … Burckhardt, G. (2008). Identification of a new urate and high affinity nicotinate transporter: hOAT10 (SCL22A13). Journal of Biological Chemistry, 283(24), 16332-16341. doi: 10.1074/jbc.M800737200
Journal - Research Article
Ugele, B., Bahn, A., & Rex-Haffner, M. (2008). Functional differences in steroid sulfate uptake of organic anion transporter 4 (OAT4) and organic anion transporting polypeptide 2B1 (OATP2B1) in human placenta. Journal of Steroid Biochemistry & Molecular Biology, 111(1-2), 1-6. doi: 10.1016/j.jsbmb.2008.04.001
Journal - Research Article
Hagos, Y., Bahn, A., Vormfelde, S. V., Brockmöller, J., & Burckhardt, G. (2007). Torasemide transport by organic anion transporters contributes to hyperuricemia. Journal of the American Society of Nephrology, 18(12), 3101-3109. doi: 10.1681/ASN.2007010106
Journal - Research Article
Hagos, Y., Stein, D., Ugele, B., Burckhardt, G., & Bahn, A. (2007). Human renal organic anion transporter 4 operates as an asymmetric urate transporter. Journal of the American Society of Nephrology, 18(2), 430-439. doi: 10.1681/ASN.2006040415
Journal - Research Article
Ljubojević, M., Balen, D., Breljak, D., Kušan, M., Anzai, N., Bahn, A., … Sabolić, I. (2007). Renal expression of organic anion transporter OAT2 in rats and mice is regulated by sex hormones. American Journal of Physiology: Renal Physiology, 292(1), F361-F372. doi: 10.1152/ajprenal.00207.2006
Journal - Research Article
Sabolić, I., Asif, A. R., Budach, W. E., Wanke, C., Bahn, A., & Burckhardt, G. (2007). Gender differences in kidney function. Pflügers Archiv: European Journal of Physiology, 455(3), 397-429. doi: 10.1007/s00424-007-0308-1
Journal - Research Article
Bakhiya, N., Stephani, M., Bahn, A., Ugele, B., Seidel, A., Burckhardt, G., & Glatt, H. (2006). Uptake of chemically reactive, DNA-damaging sulfuric acid esters into renal cells by human organic anion transporters. Journal of the American Society of Nephrology, 17(5), 1414-1421. doi: 10.1681/ASN.2005080801
Journal - Research Article
Reily-Bell, M., Bahn, A., & Katare, R. (2022). Reactive oxygen species-mediated diabetic heart disease: Mechanisms and therapies. Antioxidants & Redox Signaling, 36(10-12), 608-630. doi: 10.1089/ars.2021.0098
Journal - Research Other
Ljubojević, M., Balen, D., Breljak, D., Kusan, M., Anzai, N., Bahn, A., … Sabolic, I. (2007). Corrigendum to "Renal expression of organic anion transporter OAT2 in rats and mice is regulated by sex hormones" [Am. J. Physiol. Renal Physiol. 292(1): F361-F372]. American Journal of Physiology: Renal Physiology, 292(4), F1302. doi: 10.1152/ajprenal.zh2-4716-corr.2007
Journal - Research Other