Dr Lucia Schweitzer

Position	Research Fellow
Departments	Department of Biochemistry, Department of Psychology
Qualifications	Masters, PhD
Research summary	Neuroscience, memory, molecular biology, neuronal cell biology

Research

Lucia received her master's degree in molecular biology in 2006 at the University of Vienna, Austria. She then did her PhD on RNA localisation in neurons, investigating the role of two proteins involved in this process: Staufen2 and Pumilio2. After receiving her PhD at the University of Vienna in 2010, she moved to the University of Otago. Here, she first worked with Professor Warren Tate on a project studying secreted amyloid precursor protein alpha and its role in Alzheimer's disease and has now joined Professor Cliff Abraham and Dr Stephanie Hughes in a study investigating adult neurogenesis. She is interested in the processes necessary for memory formation and retrieval.

Publications

Ohline, S. M., Chan, C., Schoderboeck, L., Wicky, H. E., Tate, W. P., Hughes, S. M., & Abraham, W. C. (2022). Effect of soluble amyloid precursor protein-alpha on adult hippocampal neurogenesis in a mouse model of Alzheimer's disease. Molecular Brain, 15, 5. doi: 10.1186/s13041-021-00889-1

Basak, I., Wicky, H. E., McDonald, K. O., Xu, J. B., Palmer, J. E., Best, H. L., … Schoderboeck, L., & Hughes, S. M. (2021). A lysosomal enigma CLN5 and its significance in understanding neuronal ceroid lipofuscinosis. Cellular & Molecular Life Sciences, 78, 4735-4763. doi: 10.1007/s00018-021-03813-x

Mathiesen, S. N., Lock, J. L., Schoderboeck, L., Abraham, W. C., & Hughes, S. M. (2020). CNS transduction benefits of AAV-PHP.eB over AAV9 are dependent on administration route and mouse strain. Molecular Therapy: Methods & Clinical Development, 19, 447-458. doi: 10.1016/j.omtm.2020.10.011

Schoderboeck, L., Wicky, H. E., Abraham, W. C., & Hughes, S. M. (2019). Genetic targeting and chemogenetic inhibition of newborn neurons. Human Gene Therapy Methods, 29(6), 259-268. doi: 10.1089/hgtb.2018.182

Mitchell, N. L., Russell, K. N., Wellby, M. P., Wicky, H. E., Schoderboeck, L., Barrell, G. K., Melzer, T. R., … Hughes, S. M., & Palmer, D. N. (2018). Longitudinal in vivo monitoring of CNS demonstrates the efficacy of gene therapy in a sheep model of CLN5 Batten disease. Molecular Therapy, 26(10), 2366-2378. doi: 10.1016/j.ymthe.2018.07.015

Journal - Research Article

Ohline, S. M., Wake, K. L., Hawkridge, M.-V., Dinnunhan, M. F., Hegemann, R. U., Wilson, A., Schoderboeck, L., Logan, B. J., … Hughes, S. M., & Abraham, W. C. (2018). Adult-born dentate granule cell excitability depends on the interaction of neuron age, ontogenetic age and experience. Brain Structure & Function, 223(7), 3213-3228. doi: 10.1007/s00429-018-1685-2

Journal - Research Article

Tan, V. T. Y., Mockett, B. G., Ohline, S. M., Parfitt, K. D., Wicky, H. E., Peppercorn, K., Schoderboeck, L., Yahaya, M. F. b., Tate, W. P., Hughes, S. M., & Abraham, W. C. (2018). Lentivirus-mediated expression of human secreted amyloid precursor protein-alpha prevents development of memory and plasticity deficits in a mouse model of Alzheimer's disease. Molecular Brain, 11, 7. doi: 10.1186/s13041-018-0348-9

Journal - Research Article

Parr-Brownlie, L. C., Bosch-Bouju, C., Schoderboeck, L., Sizemore, R. J., Abraham, W. C., & Hughes, S. M. (2015). Lentiviral vectors as tools to understand central nervous system biology in mammalian model organisms. Frontiers in Molecular Neuroscience, 8, 14. doi: 10.3389/fnmol.2015.00014

Journal - Research Article

Schoderboeck, L., Riad, S., Bokor, A. M., Wicky, H. E., Strauss, M., Bostina, M., Oswald, M. J., Empson, R. M., & Hughes, S. M. (2015). Chimeric rabies SADB19-VSVg-pseudotyped lentiviral vectors mediate long-range retrograde transduction from the mouse spinal cord. Gene Therapy, 22, 357-364. doi: 10.1038/gt.2015.3

Journal - Research Article

Schoderboeck, L., Mühlegger, S., Lossert, A., Gausterer, C., & Hornek, R. (2010). Effects assessment: Boron compounds in the aquatic environment. Chemosphere, 82, 483-487. doi: 10.1016/j.chemosphere.2010.10.031

Journal - Research Article

Vessey, J. P., Schoderboeck, L., Ewald, G., Luzi, E., Riefler, J., Di Leva, F., … Macchi, P. (2010). Mammalian Pumilio 2 regulates dendrite morphogenesis and synaptic function. PNAS, 107(7), 3222-3227. doi: 10.1073/pnas.0907128107

Journal - Research Article

Konecna, A., Heraud, J. E., Schoderboeck, L., Raposo, A. A. S. F., & Kiebler, M. A. (2009). What are the roles of microRNAs at the mammalian synapse? [Mini-review]. Neuroscience Letters, 466(2), 63-68. doi: 10.1016/j.neulet.2009.06.050

Journal - Research Article

Schoderboeck, L., Adzemovic, M., Nicolussi, E.-M., Crupinschi, C., Hochmeister, S., Fischer, M.-T., … Bradl, M. (2009). The “window of susceptibility” for inflammation in the immature central nervous system is characterized by a leaky blood–brain barrier and the local expression of inflammatory chemokines. Neurobiology of Disease, 35(3), 368-375. doi: 10.1016/j.nbd.2009.05.026

Journal - Research Article

Grundtner, R., Dornmair, K., Dahm, R., Flügel, A., Kawakami, N., Zeitelhofer, M., Schoderboeck, L., … Bradl, M. (2007). Transition from enhanced T cell infiltration to inflammation in the myelin-degenerative central nervous system. Neurobiology of Disease, 28(3), 261-275. doi: 10.1016/j.nbd.2007.05.006

Journal - Research Article

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Dr Lucia Schweitzer

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