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Dr Martin Fronius

PositionSenior Lecturer
DepartmentDepartment of Physiology
QualificationsDiplom Biologie Dr rer nat
Research summaryEpithelial ion transport and epithelial ion channels

Research

Research in my lab focuses on the function and regulation of ion channels with particular emphasis on:
  • Impact of mechanical forces (shear stress and pressure)
  • Fluid homeostasis in the lung
  • Auto-/paracrine signalling via non-neuronal acetylcholine

Publications

Paudel, P., van Hout, I., Bunton, R. W., Parry, D. J., Coffey, S., McDonald, F. J., & Fronius, M. (2022). Epithelial sodium channel δ subunit is expressed in human arteries and has potential association with hypertension. Hypertension. Advance online publication. doi: 10.1161/hypertensionaha.122.18924

Fronius, M. (2022). Epithelial Na+ channel and the glycocalyx: A sweet and salty relationship for arterial shear stress sensing. Current Opinion in Nephrology & Hypertension. Advance online publication. doi: 10.1097/mnh.0000000000000779

Perkinson, M., Augustine, R. A., Bouwer, G. T., Brown, E. F., Cheong, I., Seymour, A. J., Fronius, M., & Brown, C. H. (2021). Plasticity in intrinsic excitability of hypothalamic magnocellular neurosecretory neurons in late-pregnant and lactating rats. International Journal of Molecular Sciences, 22(13), 7140. doi: 10.3390/ijms22137140

Barth, D., Knoepp, F., & Fronius, M. (2021). Enhanced shear force responsiveness of epithelial Na+ channel’s (ENaC) δ subunit following the insertion of N-glycosylation motifs relies on the extracellular matrix. International Journal of Molecular Sciences, 22(5), 2500. doi: 10.3390/ijms22052500

Saw, E. L., Pearson, J. T., Schwenke, D. O., Munasinghe, P. E., Tsuchimochi, H., Rawal, S., Coffey, S., … Bunton, R., Van Hout, I., … Williams, M. J. A., … Fronius, M., & Katare, R. (2021). Activation of the cardiac non-neuronal cholinergic system prevents the development of diabetes-associated cardiovascular complications. Cardiovascular Diabetology, 20, 50. doi: 10.1186/s12933-021-01231-8

Fronius, M. (2012). Mechanical forces impair alveolar ion transport processes: A putative mechanism contributing to the formation of pulmonary edema. In E. M. Irusen (Ed.), Lung diseases: Selected state of the art reviews. (pp. 561-578). Rijeka, Croatia: InTech.

Chapter in Book - Research

Paudel, P., van Hout, I., Bunton, R. W., Parry, D. J., Coffey, S., McDonald, F. J., & Fronius, M. (2022). Epithelial sodium channel δ subunit is expressed in human arteries and has potential association with hypertension. Hypertension. Advance online publication. doi: 10.1161/hypertensionaha.122.18924

Journal - Research Article

Barth, D., Knoepp, F., & Fronius, M. (2021). Enhanced shear force responsiveness of epithelial Na+ channel’s (ENaC) δ subunit following the insertion of N-glycosylation motifs relies on the extracellular matrix. International Journal of Molecular Sciences, 22(5), 2500. doi: 10.3390/ijms22052500

Journal - Research Article

Perkinson, M., Augustine, R. A., Bouwer, G. T., Brown, E. F., Cheong, I., Seymour, A. J., Fronius, M., & Brown, C. H. (2021). Plasticity in intrinsic excitability of hypothalamic magnocellular neurosecretory neurons in late-pregnant and lactating rats. International Journal of Molecular Sciences, 22(13), 7140. doi: 10.3390/ijms22137140

Journal - Research Article

Saw, E. L., Pearson, J. T., Schwenke, D. O., Munasinghe, P. E., Tsuchimochi, H., Rawal, S., Coffey, S., … Bunton, R., Van Hout, I., … Williams, M. J. A., … Fronius, M., & Katare, R. (2021). Activation of the cardiac non-neuronal cholinergic system prevents the development of diabetes-associated cardiovascular complications. Cardiovascular Diabetology, 20, 50. doi: 10.1186/s12933-021-01231-8

Journal - Research Article

Baldin, J.-P., Barth, D., & Fronius, M. (2020). Epithelial Na+ channel (ENaC) formed by one or two subunits forms functional channels that respond to shear force. Frontiers in Physiology, 11, 141. doi: 10.3389/fphys.2020.00141

Journal - Research Article

Knoepp, F., Ashley, Z., Barth, D., Baldin, J.-P., Jennings, M., Kazantseva, M., Saw, E. L., Katare, R., … Fronius, M. (2020). Shear force sensing of epithelial Na+ channel (ENaC) relies on N-glycosylated asparagines in the palm and knuckle domains of αENaC. PNAS, 117(1), 717-726. doi: 10.1073/pnas.1911243117

Journal - Research Article

Kumar, P., Scholze, P., Fronius, M., Krasteva-Christ, G., & Hollenhorst, M. I. (2020). Nicotine stimulates ion transport via metabotropic β4 subunit containing nicotinic ACh receptors. British Journal of Pharmacology, 177, 5595-5608. doi: 10.1111/bph.15270

Journal - Research Article

Barth, D., & Fronius, M. (2019). Shear force modulates the activity of acid-sensing ion channels at low pH or in the presence of non-proton ligands. Scientific Reports, 9, 6781. doi: 10.1038/s41598-019-43097-7

Journal - Research Article

Ashley, Z., Mugloo, S., McDonald, F. J., & Fronius, M. (2018). Epithelial Na+ channel differentially contributes to shear stress-mediated vascular responsiveness in carotid and mesenteric arteries from mice. American Journal of Physiology: Heart & Circulatory Physiology, 314(5), H1022-H1032. doi: 10.1152/ajpheart.00506.2017

Journal - Research Article

Knoepp, F., Bettmer, J., & Fronius, M. (2017). Gadolinium released by the linear gadolinium-based contrast-agent Gd-DTPA decreases the activity of human epithelial Na+ channels (ENaCs). Biochimica et Biophysica Acta: Biomembranes, 1859(5), 1040-1048. doi: 10.1016/j.bbamem.2017.02.019

Journal - Research Article

Richter, K., Mathes, V., Fronius, M., Althaus, M., Hecker, A., Krasteva-Christ, G., … Grau, V. (2016). Phosphocholine: An agonist of metabotropic but not of ionotropic functions of α9-containing nicotinic acetylcholine receptors. Scientific Reports, 6, 28660. doi: 10.1038/srep28660

Journal - Research Article

Dittrich, N. P., Kummer, W., Clauss, W. G., & Fronius, M. (2015). Luminal acetylcholine does not affect the activity of the CFTR in tracheal epithelia of pigs. International Immunopharmacology, 29(1), 166-172. doi: 10.1016/j.intimp.2015.08.010

Journal - Research Article

Hecker, A., Küllmar, M., Wilker, S., Richter, K., Zakrzewicz, A., Atanasova, S., … Fronius, M., … Grau, V. (2015). Phosphocholine-modified macromolecules and canonical nicotinic agonists inhibit ATP-induced IL-1β release. Journal of Immunology, 195, 2325-2334. doi: 10.4049/jimmunol.1400974

Journal - Research Article

Vitzthum, C., Clauss, W. G., & Fronius, M. (2015). Mechanosensitive activation of CFTR by increased cell volume and hydrostatic pressure but not shear stress. Biochemica et Biophysica Acta: Biomembranes, 1848(11), 2942-2951. doi: 10.1016/j.bbamem.2015.09.009

Journal - Research Article

Ashry, O., Schnecko, A., Clauss, W. G., & Fronius, M. (2014). Evidence for expression and function of angiotensin II receptor type 1 in pulmonary epithelial cells. Respiratory Physiology & Neurobiology, 195(1), 37-40. doi: 10.1016/j.resp.2014.02.001

Journal - Research Article

Deckmann, K., Filipski, K., Krasteva-Christ, G., Fronius, M., Althaus, M., Rafiq, A., … Kummer, W. (2014). Bitter triggers acetylcholine release from polymodal urethral chemosensory cells and bladder reflexes. PNAS, 111(22), 8287-8292. doi: 10.1073/pnas.1402436111

Journal - Research Article

Richter, K., Kiefer, K. P., Grzesik, B. A., Clauss, W. G., & Fronius, M. (2014). Hydrostatic pressure activates ATP-sensitive K+ channels in lung epithelium by ATP release through pannexin and connexin hemichannels. FASEB Journal, 28(1), 45-55. doi: 10.1096/fj.13-229252

Journal - Research Article

Schönberger, M., Althaus, M., Fronius, M., Clauss, W., & Trauner, D. (2014). Controlling epithelial sodium channels with light using photoswitchable amilorides. Nature Chemistry, 6(8), 712-719. doi: 10.1038/nchem.2004

Journal - Research Article

Althaus, M., Urness, K. D., Clauss, W. G., Baines, D. L., & Fronius, M. (2012). The gasotransmitter hydrogen sulphide decreases Na+ transport across pulmonary epithelial cells. British Journal of Pharmacology, 166(6), 1946-1963. doi: 10.1111/j.1476-5381.2012.01909.x

Journal - Research Article

Hollenhorst, M. I., Lips, K. S., Weitz, A., Krasteva, G., Kummer, W., & Fronius, M. (2012). Evidence for functional atypical nicotinic receptors that activate K+-dependent Cl- secretion in mouse tracheal epithelium. American Journal of Respiratory Cell & Molecular Biology, 46(1), 106-114. doi: 10.1165/rcmb.2011-0171OC

Journal - Research Article

Hollenhorst, M. I., Lips, K. S., Wolff, M., Wess, J., Gerbig, S., Takats, Z., … Fronius, M. (2012). Luminal cholinergic signalling in airway lining fluid: A novel mechanism for activating chloride secretion via Ca 2+-dependent Cl- and K+ channels. British Journal of Pharmacology, 166(4), 1388-1402. doi: 10.1111/j.1476-5381.2012.01883.x

Journal - Research Article

Krumm, P., Giraldez, T., Alvarez de la Rosa, D., Clauss, W. G., Fronius, M., & Althaus, M. (2012). Thiol-reactive compounds from garlic inhibit the epithelial sodium channel (ENaC). Bioorganic & Medicinal Chemistry, 20(13), 3979-3984. doi: 10.1016/j.bmc.2012.05.021

Journal - Research Article

Wesch, D., Althaus, M., Miranda, P., Cruz-Muros, I., Fronius, M., González-Hernández, T., … Giraldez, T. (2012). Differential N termini in epithelial Na+ channel δ-subunit isoforms modulate channel trafficking to the membrane. American Journal of Physiology: Cell Physiology, 302(6), C868-879. doi: 10.1152/ajpcell.00255.2011

Journal - Research Article

Althaus, M., Clauss, W. G., & Fronius, M. (2011). Amiloride-sensitive sodium channels and pulmonary edema. Pulmonary Medicine, 2011, 830320. doi: 10.1155/2011/830320

Journal - Research Article

Althaus, M., Pichl, A., Clauss, W. G., Seeger, W., Fronius, M., & Morty, R. E. (2011). Nitric oxide inhibits highly selective sodium channels and the Na+/K+-ATPase in H441 cells. American Journal of Respiratory Cell & Molecular Biology, 44(1), 53-65. doi: 10.1165/2009-0335OC

Journal - Research Article

Berger, J., Richter, K., Clauss, W. G., & Fronius, M. (2011). Evidence for basolateral Cl- channels as modulators of apical Cl- secretion in pulmonary epithelia of Xenopus laevis. American Journal of Physiology: Regulatory, Integrative & Comparative Physiology, 300(3), R616-R623. doi: 10.1152/ajpregu.00464.2010

Journal - Research Article

Hollenhorst, M. I., Richter, K., & Fronius, M. (2011). Ion transport by pulmonary epithelia. Journal of Biomedicine & Biotechnology, 2011, 174306. doi: 10.1155/2011/174306

Journal - Research Article

Kessler, S., Clauss, W. G., & Fronius, M. (2011). Laminar shear stress modulates the activity of heterologously expressed P2X4 receptors. Biochimica et Biophysica Acta: Biomembranes, 1808(10), 2488-2495. doi: 10.1016/j.bbamem.2011.07.010

Journal - Research Article

Kessler, S., Clauss, W. G., Günther, A., Kummer, W., & Fronius, M. (2011). Expression and functional characterization of P2X receptors in mouse alveolar macrophages. Pflügers Archiv: European Journal of Physiology, 462(3), 419-430. doi: 10.1007/s00424-011-0980-z

Journal - Research Article

Berger, J., Hardt, M., Clauss, W. G., & Fronius, M. (2010). Basolateral Cl- uptake mechanisms in Xenopus laevis lung epithelium. American Journal of Physiology: Regulatory, Integrative & Comparative Physiology, 299(1), R92-R100. doi: 10.1152/ajpregu.00749.2009

Journal - Research Article

Fronius, M., Bogdan, R., Althaus, M., Morty, R. E., & Clauss, W. G. (2010). Epithelial Na+ channels derived from human lung are activated by shear force. Respiratory Physiology & Neurobiology, 170(1), 113-119. doi: 10.1016/j.resp.2009.11.004

Journal - Research Article

Mikulski, Z., Hartmann, P., Jositsch, G., Zasłona, Z., Lips, K. S., Pfeil, U., … Fronius, M., & Kummer, W. (2010). Nicotinic receptors on rat alveolar macrophages dampen ATP-induced increase in cytosolic calcium concentration. Respiratory Research, 11, 133. doi: 10.1186/1465-9921-11-133

Journal - Research Article

Althaus, M., Fronius, M., Buchäckert, Y., Vadász, I., Clauss, W. G., Seeger, W., … Morty, R. E. (2009). Carbon monoxide rapidly impairs alveolar fluid clearance by inhibiting epithelial sodium channels. American Journal of Respiratory Cell & Molecular Biology, 41(6), 639-650. doi: 10.1165/rcmb.2008-0458OC

Journal - Research Article

Bogdan, R., Veith, C., Clauss, W., & Fronius, M. (2008). Impact of mechanical stress on ion transport in native lung epithelium (Xenopus laevis): Short-term activation of Na+, Cl- and K+ channels. Pflügers Archiv: European Journal of Physiology, 456(6), 1109-1120. doi: 10.1007/s00424-008-0486-5

Journal - Research Article

Fronius, M., & Clauss, W. G. (2008). Mechano-sensitivity of ENaC: May the (shear) force be with you. Pflügers Archiv: European Journal of Physiology, 455(5), 775-785. doi: 10.1007/s00424-007-0332-1

Journal - Research Article

Althaus, M., Bogdan, R., Clauss, W. G., & Fronius, M. (2007). Mechano-sensitivity of epithelial sodium channels (ENaCs): Laminar shear stress increases ion channel open probability. FASEB Journal, 21(10), 2389-2399. doi: 10.1096/fj.06-7694com

Journal - Research Article

Schnizler, M. K., Bogdan, R., Bennert, A., Bury, N. R., Fronius, M., & Clauss, W. (2007). Short-term exposure to waterborne free silver has acute effects on membrane current of Xenopus oocytes. Biochimica et Biophysica Acta: Biomembranes, 1768(2), 317-323. doi: 10.1016/j.bbamem.2006.09.007

Journal - Research Article

Sommer, D., Bogdan, R., Berger, J., Peters, D. M., Morty, R. E., Clauss, W. G., & Fronius, M. (2007). CFTR-dependent Cl- secretion in Xenopus laevis lung epithelium. Respiratory Physiology & Neurobiology, 158(1), 97-106. doi: 10.1016/j.resp.2007.03.016

Journal - Research Article

Krumm, S., Goebel-Lauth, S. G., Fronius, M., & Clauss, W. (2005). Transport of sodium and chloride across earthworm skin in vitro. Journal of Comparative Physiology B, 175, 601-608. doi: 10.1007/s00360-005-0023-1

Journal - Research Article

Berk, A., Fronius, M., Clauss, W., & Schnizler, M. (2004). Prostaglandin E2 induces upregulation of Na+ transport across Xenopus lung epithelium. Journal of Comparative Physiology B, 174, 83-89. doi: 10.1007/s00360-003-0391-3

Journal - Research Article

Fronius, M., Berk, A., Clauss, W., & Schnizler, M. (2004). Ion transport across Xenopus alveolar epithelium is regulated by extracellular ATP, UTP and adenosine. Respiratory Physiology & Neurobiology, 139, 133-144. doi: 10.1016/j.resp.2003.09.007

Journal - Research Article

Fronius, M., Clauss, W., & Schnizler, M. (2003). Stimulation of transepithelial Na+ current by extracellular Gd3+ in Xenopus laevis alveolar epithelium. Journal of Membrane Biology, 195(1), 43-51. doi: 10.1007/s00232-003-2043-7

Journal - Research Article

Fronius, M., Rehn, M., Eckstein-Ludwig, U., & Clauss, W. (2001). Inhibitory non-genomic effects of progesterone on Na+ absorption in epithelial cells from Xenopus kidney (A6). Journal of Comparative Physiology B, 171, 377-386. doi: 10.1007/s003600100186

Journal - Research Article

Fronius, M. (2022). Epithelial Na+ channel and the glycocalyx: A sweet and salty relationship for arterial shear stress sensing. Current Opinion in Nephrology & Hypertension. Advance online publication. doi: 10.1097/mnh.0000000000000779

Journal - Research Other

Paudel, P., McDonald, F. J., & Fronius, M. (2021). The δ subunit of epithelial sodium channel in humans: A potential player in vascular physiology. American Journal of Physiology: Heart & Circulatory Physiology, 320, H487-H493. doi: 10.1152/ajpheart.00800.2020

Journal - Research Other

Saw, E. L., Kakinuma, Y., Fronius, M., & Katare, R. (2018). The non-neuronal cholinergic system in the heart: A comprehensive review. Journal of Molecular & Cellular Cardiology, 125, 129-139. doi: 10.1016/j.yjmcc.2018.10.013

Journal - Research Other

Fronius, M. (2013). Treatment of pulmonary edema by ENaC activators/stimulators. Current Molecular Pharmacology, 6(1), 13-27. doi: 10.2174/1874467211306010003

Journal - Research Other

Fronius, M., Clauss, W. G., & Althaus, M. (2012). Why do we have to move fluid to be able to breathe? Frontiers in Physiology, 3, 146. doi: 10.3389/fphys.2012.00146

Journal - Research Other

Hollenhorst, M. I., Clauss, W., & Fronius, M. (2012). Acetylcholin als non-neuronales Signalmolekül [The non-neuronal cholinergic system]. Biologie in unserer Zeit, 42(6), 390-395. doi: 10.1002/biuz.201210495

Journal - Research Other

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