Professor Paul Smith
Position | Professor |
---|---|
Department | Department of Pharmacology and Toxicology |
Qualifications | BA(Hons) PhD GradDipApplStat MApplStat(Hons) DSc AStat (SSAI) |
Research summary | Vestibular and Auditory Neuroscience |
Teaching |
|
Research
Interests: vestibular and auditory systems; vestibular dysfunction and tinnitus; effects of vestibular damage on the hippocampus; applications of statistics to pharmacology; biostatistics in general.
My major research interest is in the vestibular and auditory systems and how damage to them can result in plastic changes in the brain. We study the effects of vestibular and auditory damage on the brainstem vestibular and cochlear nuclei, and also on other areas of the CNS such as the medial temporal lobe, especially the hippocampus and striatum.
Additional details
I am appointed to the HRC Standing Committee on Therapeutic Trials (SCOTT), the HRC Emerging Researcher First Grant Science Assessing CommitteeScientific Advisory Committee of the New Zealand Neurological Foundation, and to the Editorial Boards of the Journal of Vestibular Research, Frontiers in NeurologyNeuro-Otology (Associate Editor), Frontiers in Neuroscience, Frontiers in Psychology, Auris Nasus Larynx and the Springer Encyclopedia of Neuroscience (Field Editor for Neuropharmacology).
I am an Accredited Statistician (AStat) with the Statistical Society of Australia Inc. (SSAI) and a Fellow of the Royal Statistical Society, UK. I am also a Principal Investigator with the Brain Research New Zealand Centre of Research Excellence and with the Eisdell Moore Centre for Hearing and Balance Research, University of Auckland.
Publications
McLaren, R., Smith, P. F., Taylor, R. L., Niazi, I. K., & Taylor, D. (2023). Scoping out noisy galvanic vestibular stimulation: A review of the parameters used to improve postural control. Frontiers in Neuroscience, 17, 1156796. doi: 10.3389/fnins.2023.1156796
Tashakori-Sabzevar, F., Vautrelle, N., Zheng, Y., & Smith, P. F. (2023). Vestibular modulation of the tail of the rat striatum. Scientific Reports, 13, 4443. doi: 10.1038/s41598-023-31289-1
Rana, Z., Rosengren, R., & Smith, P. (2022). Exploring the mechanism and suggesting combination therapies for HDAC inhibitors in androgen receptor-null prostate cancer using multivariate statistical analysis and data mining techniques. Bioinformatics & Biology Insights. Advance online publication. doi: 10.1177/11779322221145428
McLaren, R., Smith, P. F., Taylor, R. L., Ravindran, S., Rashid, U., & Taylor, D. (2022). Efficacy of nGVS to improve postural stability in people with bilateral vestibulopathy: A systematic review and meta-analysis. Frontiers in Neuroscience, 16, 1010239. doi: 10.3389/fnins.2022.1010239
Curthoys, I. S., Smith, P. F., & Ramos de Miguel, A. (2022). Why should constant stimulation of saccular afferents modify the posture and gait of patients with bilateral vestibular dysfunction? The saccular substitution hypothesis. Journal of Clinical Medicine, 11(4), 1132. doi: 10.3390/jcm11041132
Smith, P. F. (2002). Cannabis on the Brain. Palmerston North: Dunmore Press, 228p.
Authored Book - Research
Smith, P. F., & Darlington, C. L. (1996). Clinical Psychopharmacology: A Primer. New York: Lawrence Erlbaum Associates, 143p.
Authored Book - Research
He, J., Aa, J.-Y., Sun, J.-G., Smith, P. F., De Ridder, D., Wang, G.-J., & Zheng, Y. (2021). Metabolic changes in the brain and blood of rats following acoustic trauma, tinnitus and hyperacusis. In B. Langguth, T. Kleinjung, D. De Ridder, W. Schlee & S. Vanneste (Eds.), Tinnitus: An interdisciplinary approach towards individualized treatment: Towards understanding the complexity of tinnitus: Progress in brain research (Vol. 262). (pp. 399-430). Amsterdam, The Netherlands: Elsevier. doi: 10.1016/bs.pbr.2020.09.002
Chapter in Book - Research
Searchfield, G. D., Zhang, J., Biswas, R., De Ridder, D., Deutsch, B., Hall, D. A., … Kleinstäuber, M., … Smith, P. F., … Zheng, Y. (2021). Emerging topics in the behavioral neuroscience of tinnitus. In G. D. Searchfield & J. Zhang (Eds.), The behavioral neuroscience of tinnitus: Current topics in behavioral neurosciences (Vol. 51). (pp. 461-484). Cham, Switzerland: Springer. doi: 10.1007/7854_2021_217
Chapter in Book - Research
Zheng, Y., McTavish, J., & Smith, P. F. (2021). Pharmacological evaluation of drugs in animal models of tinnitus. In G. D. Searchfield & J. Zhang (Eds.), The behavioral neuroscience of tinnitus: Current topics in behavioral neurosciences (Vol. 51). (pp. 51-82). Cham, Switzerland: Springer. doi: 10.1007/7854_2020_212
Chapter in Book - Research
Agrawal, Y., Smith, P. F., & Merfeld, D. M. (2020). Dizziness, imbalance and age-related vestibular loss. In J. Stein (Ed.), Reference module in neuroscience and biobehavioral psychology. Elsevier. doi: 10.1016/B978-0-12-809324-5.23818-2
Chapter in Book - Research
Smith, P. F. (2019). Vestibular compensation as a distributed process. In J. P. Stein (Ed.), Reference module in neuroscience and biobehavioral psychology. Elsevier. doi: 10.1016/B978-0-12-809324-5.23820-0
Chapter in Book - Research
Vidal, P. P., Cullen, K., Curthoys, I. S., Du Lac, S., Holstein, G., Idoux, E., … Smith, P. (2015). The vestibular system. In G. Paxinos (Ed.), The rat nervous system. (4th ed.) (pp. 805-864). London, UK: Academic Press. doi: 10.1016/B978-0-12-374245-2.00028-0
Chapter in Book - Research
Smith, P. F. (2011). The endocannabinoid system in the cochlear nucleus and its implications for tinnitus treatment. In A. R. Møller, B. Langguth, D. De Ridder & T. Kleinjung (Eds.), Textbook of tinnitus. (pp. 639-647). New York: Springer. doi: 10.1007/978-1-60761-145-5_79
Chapter in Book - Research
Darlington, C. L., Zheng, Y., & Smith, P. F. (2009). Herbal medicinal products for tinnitus: Perspectives and evaluation. In P. Houghton & P. K. Mukherjee (Eds.), Evaluation of herbal medicinal products. (pp. 314-321). London: Pharmaceutical Press.
Chapter in Book - Research
Smith, P. F., Darlington, C. L., & Zheng, Y. (2009). Cognitive deficits following complete bilateral loss of vestibular function and their relationship to the hippocampus. In A. Lindqvist & G. Nyman (Eds.), Dizziness: Vertigo, disequilibrium and lightheadedness. New York: Nova Science.
Chapter in Book - Research
Ashton, J. C., & Smith, P. F. (2007). Bcl-2 and mitochondrial control of apoptosis as a mechanism for regulating neural plasticity. In L. B. Shultz (Ed.), Cell Apoptosis: Regulation and Environmental Factors. (pp. 1-23). New York: Nova Science.
Chapter in Book - Research
Smith, P. F., Zheng, Y., Goddard, M., & Darlington, C. L. (2007). Cognitive impairment due to inner ear damage. In H. C. Sentowski (Ed.), Cognitive Disorders Research Trends. (pp. 231-243). New York: Nova Science.
Chapter in Book - Research
Smith, P. F. (2005). Cannabis and cannabinoids for the symptomatic treatment of multiple sclerosis. In F. Columbus (Ed.), Treatment and management of multiple sclerosis. (pp. 155-167). New York, NY: Nova Science Publishers.
Chapter in Book - Research
Smith, P. F. (2005). Medicinal use of cannabis: Implications for lung cancer. In R. L. Carafaro (Ed.), Focus on lung cancer research. (pp. 193-209). New York, NY: Nova Science Publishers.
Chapter in Book - Research
Smith, P. F., & Darlington, C. L. (2000). The contributions of excitatory and inhibitory amino acid neurotransmitters to vestibular plasticity. In A. J. Beitz & J. H. Anderson (Eds.), Neurochemistry of the Vestibular System. (pp. 381-401). New York: CRC Press.
Chapter in Book - Research
Darlington, C. L., Smith, P. F., & Maclennan, K. M. (1999). The neuroprotective properties of ginkgo extracts. In T. A. Van Beek (Ed.), Medicinal and Aromatic Plants - Industrial Profiles: Ginkgo Biloba. (pp. 331-344). Amsterdam: Harwood Academic Publishers.
Chapter in Book - Research
Smith, P. F., & Darlington, C. L. (1998). Neural mechanisms of psychiatric disturbances in patients with epilepsy. In H. McDonnell & P. Snyder (Eds.), Psychiatric co-morbidity in epilepsy: Basic mechanisms, diagnosis and treatment. (pp. 15-35). Washington DC: American Psychiatric Press.
Chapter in Book - Research
Darlington, C. L., Smith, P. F., & Maclennan, K. M. (1997). Effects of Ginkgo biloba extract (EGb 761) on recovery from peripheral vestibular deafferentation (vestibular compensation). In V. Papadopoulos, K. Drieu & Y. Christen (Eds.), Advances in Ginkgo biloba Research, Vol. 6. (pp. 47-58). Paris: Elsevier.
Chapter in Book - Research
Darlington, C., & Smith, P. (1996). What neurotransmitters are important in the vestibular system? In R. Baloh & G. M. Halmagyi (Eds.), Disorders of the Vestibular System. (pp. 140-144). New York: Oxford University Press.
Chapter in Book - Research
Tashakori-Sabzevar, F., Vautrelle, N., Zheng, Y., & Smith, P. F. (2023). Vestibular modulation of the tail of the rat striatum. Scientific Reports, 13, 4443. doi: 10.1038/s41598-023-31289-1
Journal - Research Article
McLaren, R., Smith, P. F., Taylor, R. L., Ravindran, S., Rashid, U., & Taylor, D. (2022). Efficacy of nGVS to improve postural stability in people with bilateral vestibulopathy: A systematic review and meta-analysis. Frontiers in Neuroscience, 16, 1010239. doi: 10.3389/fnins.2022.1010239
Journal - Research Article
Rana, Z., Rosengren, R., & Smith, P. (2022). Exploring the mechanism and suggesting combination therapies for HDAC inhibitors in androgen receptor-null prostate cancer using multivariate statistical analysis and data mining techniques. Bioinformatics & Biology Insights. Advance online publication. doi: 10.1177/11779322221145428
Journal - Research Article
Hitier, M., Zhang, Y.-F., Sato, G., Besnard, S., Zheng, Y., & Smith, P. F. (2021). Stratification of hippocampal electrophysiological activation evoked by selective electrical stimulation of different angular and linear acceleration sensors in the rat peripheral vestibular system. Hearing Research, 403, 108173. doi: 10.1016/j.heares.2021.108173
Journal - Research Article
Smith, P. F., & Zheng, Y. (2021). Applications of multivariate statistical and data Mining analyses to the search for biomarkers of sensorineural hearing loss, tinnitus, and vestibular dysfunction. Frontiers in Neurology, 12, 627294. doi: 10.3389/fneur.2021.627294
Journal - Research Article
Jacob, A., Tward, D. J., Resnick, S., Smith, P. F., Lopez, C., Rebello, E., … Agrawal, Y. (2020). Vestibular function and cortical and sub-cortical alterations in an aging population. Heliyon, 6(8), e04728. doi: 10.1016/j.heliyon.2020.e04728
Journal - Research Article
Kumari, N., Taylor, D., Rashid, U., Vandal, A. C., Smith, P. F., & Signal, N. (2020). Cerebellar transcranial direct current stimulation for learning a novel split-belt treadmill task: a randomised controlled trial. Scientific Reports, 10(1), 11853. doi: 10.1038/s41598-020-68825-2
Journal - Research Article
Logerot, P., Smith, P. F., Wild, M., & Kubke, M. F. (2020). Auditory processing in the zebra finch midbrain: Single unit responses and effect of rearing experience. PeerJ, 8, e9363. doi: 10.7717/peerj.9363
Journal - Research Article
Smith, P. F. (2020). Why dizziness is likely to increase the risk of cognitive dysfunction and dementia in elderly adults. New Zealand Medical Journal, 133(1522), 112-127. Retrieved from https://www.nzma.org.nz/journal
Journal - Research Article
Smith, P. F. (2020). Why the cerebellar shutdown/clampdown hypothesis of vestibular compensation is inconsistent with neurophysiological evidence. Journal of Vestibular Research, 30(5), 295-303. doi: 10.3233/ves-200715
Journal - Research Article
Le Gall, A., Hilber, P., Chesneau, C., Bulla, J., Toulouse, J., Machado, M. L., … Smith, P. F., & Besnard, S. (2019). The critical role of vestibular graviception during cognitivo-motor development. Behavioural Brain Research, 372, 112040. doi: 10.1016/j.bbr.2019.112040
Journal - Research Article
Machado, M. L., Lefèvre, N., Philoxene, B., Le Gall, A., Madeleine, S., Fleury, P., Smith, P. F., & Besnard, S. (2019). New software dedicated to virtual mazes for human neurocognitive investigations. Journal of Neuroscience Methods, 327, 108388. doi: 10.1016/j.jneumeth.2019.108388
Journal - Research Article
Martey, O. N. K., Greish, K., Smith, P. F., & Rosengren, R. J. (2019). A multivariate statistical analysis of the effects of styrene maleic acid encapsulated RL71 in a xenograft model of triple negative breast cancer. Journal of Biological Methods, 6(4). doi: 10.14440/jbm.2019.306
Journal - Research Article
Truchet, B., Benoit, A., Chaillan, F., Smith, P. F., Philoxene, B., Guillamin, M., … Besnard, S. (2019). Hippocampal LTP modulation and glutamatergic receptors following vestibular loss. Brain Structure & Function, 224, 699-711. doi: 10.1007/s00429-018-1792-0
Journal - Research Article
Aitken, P., Zheng, Y., & Smith, P. F. (2018). The modulation of hippocampal theta rhythm by the vestibular system. Journal of Neurophysiology, 119(2), 548-562. doi: 10.1152/jn.00548.2017
Journal - Research Article
Benoit, A., Besnard, S., Guillamin, M., Philoxene, B., Sola, B., Le Gall, A., … Smith, P. F. (2018). Differential regulation of NMDA receptor-expressing neurons in the rat hippocampus and striatum following bilateral vestibular loss demonstrated using flow cytometry. Neuroscience Letters, 683, 43-47. doi: 10.1016/j.neulet.2018.06.035
Journal - Research Article
Benoit, A., Guillamin, M., Aitken, P., Smith, P. F., Sola, B., Poulain, L., … Besnard, S. (2018). Flow cytometry for receptor analysis from ex-vivo brain tissue in adult rat. Journal of Neuroscience Methods, 304, 11-23. doi: 10.1016/j.jneumeth.2018.04.005
Journal - Research Article
Hitier, M., Sato, G., Zhang, Y.-F., Besnard, S., & Smith, P. F. (2018). Effects of electrical stimulation of the rat vestibular labyrinth on c-Fos expression in the hippocampus. Neuroscience Letters, 677, 60-64. doi: 10.1016/j.neulet.2018.04.041
Journal - Research Article
Hitier, M., Sato, G., Zhang, Y.-F., Zheng, Y., Besnard, S., & Smith, P. F. (2018). Vestibular-related eye movements in the rat following selective electrical stimulation of the vestibular sensors. Journal of Comparative Physiology A, 204, 835-847. doi: 10.1007/s00359-018-1286-9
Journal - Research Article
Smith, P. F. (2018). Vestibular functions and Parkinson’s Disease. Frontiers in Neurology, 9, 1085. doi: 10.3389/fneur.2018.01085
Journal - Research Article
Stiles, L., Reynolds, J. N., Napper, R., Zheng, Y., & Smith, P. F. (2018). Single neuron activity and c-Fos expression in the rat striatum following electrical stimulation of the peripheral vestibular system. Physiological Reports, 6(13), e13791. doi: 10.14814/phy2.13791
Journal - Research Article
Stiles, L., Zheng, Y., & Smith, P. F. (2018). The effects of electrical stimulation of the peripheral vestibular system on neurochemical release in the rat striatum. PLoS ONE, 13(10), e0205869. doi: 10.1371/journal.pone.0205869
Journal - Research Article
Abouzayd, M., Smith, P. F., Moreau, S., & Hitier, M. (2017). What vestibular tests to choose in symptomatic patients after a cochlear implant? A systematic review and meta-analysis. European Archives of Oto-Rhino-Laryngology, 274(1), 53-63. doi: 10.1007/s00405-016-4007-4
Journal - Research Article
Aitken, P., Zheng, Y., & Smith, P. F. (2017). Effects of bilateral vestibular deafferentation in rat on hippocampal theta response to somatosensory stimulation, acetylcholine release, and cholinergic neurons in the pedunculopontine tegmental nucleus. Brain Structure & Function, 222(7), 3319-3332. doi: 10.1007/s00429-017-1407-1
Journal - Research Article
Aitken, P., Zheng, Y., & Smith, P. F. (2017). Ethovision™ analysis of open field behaviour in rats following bilateral vestibular loss. Journal of Vestibular Research, 27, 89-101. doi: 10.3233/VES-170612
Journal - Research Article
He, J., Zhu, Y., Aa, J., Smith, P. F., De Ridder, D., Wang, G., & Zheng, Y. (2017). Brain metabolic changes in rats following acoustic trauma. Frontiers in Neuroscience, 11, 148. doi: 10.3389/fnins.2017.00148
Journal - Research Article
Liu, P., Gupta, N., Jing, Y., Collie, N. D., Zhang, H., & Smith, P. F. (2017). Further studies of the effects of aging on arginine metabolites in the rat vestibular nucleus and cerebellum. Neuroscience, 348, 273-287. doi: 10.1016/j.neuroscience.2017.02.033
Journal - Research Article
Smith, P. F. (2017). Bionic balance organs: Progress in the development of vestibular prostheses. New Zealand Medical Journal, 130(1461), 56-65. Retrieved from http://www.nzma.org.nz/journal
Journal - Research Article
Smith, P. F. (2017). Is hippocampal neurogenesis modulated by the sensation of self-motion encoded by the vestibular system? Neuroscience & Biobehavioral Reviews, 83, 489-495. doi: 10.1016/j.neubiorev.2017.09.013
Journal - Research Article
Smith, P. F. (2017). The vestibular system and cognition. Current Opinion in Neurology, 30(1), 84-89. doi: 10.1097/wco.0000000000000403
Journal - Research Article
Zheng, Y., Gliddon, C. M., Aitken, P., Stiles, L., Machado, M.-L., Philoxene, B., … Smith, P. F., & Besnard, S. (2017). Effects of acute altered gravity during parabolic flight and/or vestibular loss on cell proliferation in the rat dentate gyrus. Neuroscience Letters, 654, 120-124. doi: 10.1016/j.neulet.2017.06.033
Journal - Research Article
Aitken, P., Benoit, A., Zheng, Y., Philoxene, B., Le Gall, A., Denise, P., … Smith, P. F. (2016). Hippocampal and striatal M1-muscarinic acetylcholine receptors are down-regulated following bilateral vestibular loss in rats. Hippocampus, 26(12), 1509-1514. doi: 10.1002/hipo.22651
Journal - Research Article
Balabhadrapatruni, S., Zheng, Y., Napper, R., & Smith, P. F. (2016). Basal dendritic length is reduced in the rat hippocampus following bilateral vestibular deafferentation. Neurobiology of Learning & Memory, 131, 56-60. doi: 10.1016/j.nlm.2016.03.009
Journal - Research Article
Hitier, M., Sato, G., Zhang, Y.-f., Zheng, Y., Besnard, S., Smith, P. F., & Curthoys, I. S. (2016). Anatomy and surgical approach of rat’s vestibular sensors and nerves. Journal of Neuroscience Methods, 270, 1-8. doi: 10.1016/j.jneumeth.2016.05.013
Journal - Research Article
Smith, P. F. (2016). Age-related neurochemical changes in the vestibular nuclei. Frontiers in Neurology, 7, 20. doi: 10.3389/fneur.2016.00020
Journal - Research Article
Smith, P. F., & Zheng, Y. (2016). Cannabinoids, cannabinoid receptors and tinnitus. Hearing Research, 332, 210-216. doi: 10.1016/j.heares.2015.09.014
Journal - Research Article
Smith, P. F., Renner, R. M., & Haslett, S. J. (2016). Compositional data in neuroscience: If you've got it, log it! Journal of Neuroscience Methods, 271, 154-159. doi: 10.1016/j.jneumeth.2016.07.008
Journal - Research Article
Tranter-Entwistle, I., Dawes, P., Darlington, C. L., Smith, P. F., & Cutfield, N. (2016). Video head impulse in comparison to caloric testing in unilateral vestibular schwannoma. Acta Oto-Laryngologica, 136(11), 1110-1114. doi: 10.1080/00016489.2016.1185540
Journal - Research Article
Stiles, L., & Smith, P. F. (2015). The vestibular-basal ganglia connection: Balancing motor control. Brain Research, 1597, 180-188. doi: 10.1016/j.brainres.2014.11.063
Journal - Research Article
Zheng, Y., Dixon, S., McPherson, K., & Smith, P. F. (2015). Glutamic acid decarboxylase levels in the cochlear nucleus of rats with acoustic trauma-induced chronic tinnitus. Neuroscience Letters, 586, 60-64. doi: 10.1016/j.neulet.2014.11.047
Journal - Research Article
Zheng, Y., McPherson, K., Reid, P., & Smith, P. F. (2015). The anti-inflammatory selective melanocortin receptor subtype 4 agonist, RO27-3225, fails to prevent acoustic trauma-induced tinnitus in rats. European Journal of Pharmacology, 761, 206-210. doi: 10.1016/j.ejphar.2015.05.007
Journal - Research Article
Zheng, Y., Reid, P., & Smith, P. F. (2015). Cannabinoid CB1 receptor agonists do not decrease, but may increase, acoustic trauma-induced tinnitus in rats. Frontiers in Neurology, 6, 60. doi: 10.3389/fneur.2015.00060
Journal - Research Article
Zheng, Y., Smithies, H., Aitken, P., Gliddon, C., Stiles, L., Darlington, C. L., & Smith, P. F. (2015). Cell proliferation in the cochlear nucleus following acoustic trauma in rat. Neuroscience, 303, 524-534. doi: 10.1016/j.neuroscience.2015.07.033
Journal - Research Article
Hitier, M., Besnard, S., & Smith, P. F. (2014). Vestibular pathways involved in cognition. Frontiers in Integrative Neuroscience, 8, 59. doi: 10.3389/fnint.2014.00059
Journal - Research Article
Rivers-Auty, J. R., Smith, P. F., & Ashton, J. C. (2014). The cannabinoid CB2 receptor agonist GW405833 does not ameliorate brain damage induced by hypoxia-ischemia in rats. Neuroscience Letters, 569, 104-109. doi: 10.1016/j.neulet.2014.03.077
Journal - Research Article
Smith, P. F., & Zheng, Y. (2014). Cannabis, cannabinoids and tinnitus. Journal of Pharmacology & Drug Metabolism, 1, 1-6. Retrieved from http://www.jscholaronline.org/journals/journal-of-pharmacology-and-drug-metabolism/jhome.php
Journal - Research Article
Smith, P. F., Darlington, C. L., & Zheng, Y. (2014). The effects of complete vestibular deafferentation on spatial memory and the hippocampus in rat: The Dunedin experience. Multisensory Research, 28(5-6), 461-485. doi: 10.1163/22134808-00002469
Journal - Research Article
Zheng, Y., Geddes, L., Sato, G., Stiles, L., Darlington, C. L., & Smith, P. F. (2014). Galvanic vestibular stimulation impairs cell proliferation and neurogenesis in the rat hippocampus but not spatial memory. Hippocampus, 24(5), 541-552. doi: 10.1002/hipo.22247
Journal - Research Article
Zheng, Y., McPherson, K., & Smith, P. F. (2014). Effects of early and late treatment with L-baclofen on the development and maintenance of tinnitus caused by acoustic trauma in rats. Neuroscience, 258, 410-421. doi: 10.1016/j.neuroscience.2013.11.032
Journal - Research Article
Zheng, Y., Stiles, L., Chien, Y.-T., Darlington, C. L., & Smith, P. F. (2014). The effects of acute stress-induced sleep disturbance on acoustic trauma-induced tinnitus in rats. BioMed Research International, 2014, 724195. doi: 10.1155/2014/724195
Journal - Research Article
Baek, J.-H., Darlington, C. L., Smith, P. F., & Ashton, J. C. (2013). Antibody testing for brain immunohistochemistry: Brain immunolabeling for the cannabinoid CB2 receptor. Journal of Neuroscience Methods, 216(2), 87-95. doi: 10.1016/j.jneumeth.2013.03.021
Journal - Research Article
Smith, P. F., & Zheng, Y. (2013). From ear to uncertainty: Vestibular contributions to cognitive function. Frontiers in Integrative Neuroscience, 7, 84. doi: 10.3389/fnint.2013.00084
Journal - Research Article
Smith, P. F., & Zheng, Y. (2013). Principal component analysis suggests subtle changes in glutamate receptor subunit expression in the rat hippocampus following bilateral vestibular deafferentation. Neuroscience Letters, 548, 265-268. doi: 10.1016/j.neulet.2013.05.036
Journal - Research Article
Smith, P. F., Ganesh, S., & Liu, P. (2013). A comparison of random forest regression and multiple linear regression for prediction in neuroscience. Journal of Neuroscience Methods, 220(1). doi: 10.1016/j.jneumeth.2013.08.024
Journal - Research Article
Smith, P. F., Haslett, S., & Zheng, Y. (2013). A multivariate statistical and data mining analysis of spatial memory–related behaviour following bilateral vestibular loss in the rat. Behavioural Brain Research, 246, 15-23. doi: 10.1016/j.bbr.2013.02.033
Journal - Research Article
Zheng, Y., Wilson, G., Stiles, L., & Smith, P. F. (2013). Glutamate receptor subunit and calmodulin kinase II expression, with and without T maze training, in the rat hippocampus following bilateral vestibular deafferentation. PLoS ONE, 8(2), e54527. doi: 10.1371/journal.pone.0054527
Journal - Research Article
Neo, P., Carter, D., Zheng, Y., Smith, P., Darlington, C., & McNaughton, N. (2012). Septal elicitation of hippocampal theta rhythm did not repair cognitive and emotional deficits resulting from vestibular lesions. Hippocampus, 22(5), 1176-1187. doi: 10.1002/hipo.20963
Journal - Research Article
Smith, P. F. (2012). Dyscalculia and vestibular function. Medical Hypotheses, 79(4), 493-496. doi: 10.1016/j.mehy.2012.06.032
Journal - Research Article
Stiles, L., Zheng, Y., Darlington, C. L., & Smith, P. F. (2012). The D2 dopamine receptor and locomotor hyperactivity following bilateral vestibular deafferentation in the rat. Behavioural Brain Research, 227(1), 150-158. doi: 10.1016/j.bbr.2011.11.006
Journal - Research Article
Stiles, L., Zheng, Y., Darlington, C. L., & Smith, P. F. (2012). The effects of the D2 dopamine receptor antagonist, eticlopride, on attention following bilateral vestibular deafferentation in the rat. Neuroscience Letters, 506(2), 193-197. doi: 10.1016/j.neulet.2011.11.003
Journal - Research Article
Zheng, Y., Balabhadrapatruni, S., Baek, J. H., Chung, P., Gliddon, C., Zhang, M., Darlington, C. L., Napper, R., … Smith, P. F. (2012). The effects of bilateral vestibular loss on hippocampal volume, neuronal number, and cell proliferation in rats. Frontiers in Neurology, 3, 20. doi: 10.3389/fneur.2012.00020
Journal - Research Article
Zheng, Y., Cheung, I., & Smith, P. F. (2012). Performance in anxiety and spatial memory tests following bilateral vestibular loss in the rat and effects of anxiolytic and anxiogenic drugs. Behavioural Brain Research, 235(1), 21-29. doi: 10.1016/j.bbr.2012.07.025
Journal - Research Article
Zheng, Y., McNamara, E., Stiles, L., Darlington, C. L., & Smith, P. F. (2012). Evidence that memantine reduces chronic tinnitus caused by acoustic trauma in rats. Frontiers in Neurology, 3, 127. doi: 10.3389/fneur.2012.00127
Journal - Research Article
Zheng, Y., Vagal, S., McNamara, E., Darlington, C. L., & Smith, P. F. (2012). A dose–response analysis of the effects of L-baclofen on chronic tinnitus caused by acoustic trauma in rats. Neuropharmacology, 62, 940-946. doi: 10.1016/j.neuropharm.2011.09.027
Journal - Research Article
Baek, J. H., Zheng, Y., Darlington, C. L., & Smith, P. F. (2011). Cannabinoid CB1 receptor expression and affinity in the rat hippocampus following bilateral vestibular deafferentation. Neuroscience Letters, 487(3), 330-334. doi: 10.1016/j.neulet.2010.10.050
Journal - Research Article
Hüfner, K., Strupp, M., Smith, P., Brandt, T., & Jahn, K. (2011). Spatial separation of visual and vestibular processing in the human hippocampal formation. Annals of the New York Academy of Sciences, 1233, 177-186. doi: 10.1111/j.1749-6632.2011.06115.x
Journal - Research Article
Zheng, Y., Balabhadrapatruni, S., Masumura, C., Darlington, C. L., & Smith, P. F. (2011). Effects of the putative cognitive-enhancing ampakine, CX717, on attention and object recognition memory. Current Alzheimer Research, 8(8), 876-882. doi: 10.2174/156720511798192709
Journal - Research Article
Zheng, Y., Begum, S., Zhang, C., Fleming, K., Masumura, C., Zhang, M., Smith, P., & Darlington, C. (2011). Increased BrdU incorporation reflecting DNA repair, neuronal de-differentiation or possible neurogenesis in the adult cochlear nucleus following bilateral cochlear lesions in the rat. Experimental Brain Research, 210(3-4), 477-487. doi: 10.1007/s00221-010-2491-0
Journal - Research Article
Zheng, Y., Hamilton, E., Begum, S., Smith, P. F., & Darlington, C. L. (2011). The effects of acoustic trauma that can cause tinnitus on spatial performance in rats. Neuroscience, 186, 48-56. doi: 10.1016/j.neuroscience.2011.04.052
Journal - Research Article
Zheng, Y., Hamilton, E., McNamara, E., Smith, P. F., & Darlington, C. L. (2011). The effects of chronic tinnitus caused by acoustic trauma on social behaviour and anxiety in rats. Neuroscience, 193, 143-153. doi: 10.1016/j.neuroscience.2011.07.026
Journal - Research Article
Zheng, Y., Hamilton, E., Stiles, L., McNamara, E., de Waele, C., Smith, P. F., & Darlington, C. L. (2011). Acoustic trauma that can cause tinnitus impairs impulsive control but not performance accuracy in the 5-choice serial reaction time task in rats. Neuroscience, 180, 75-84. doi: 10.1016/j.neuroscience.2011.02.040
Journal - Research Article
Baek, J. H., Zheng, Y., Darlington, C. L., & Smith, P. F. (2010). Evidence that spatial memory deficits following bilateral vestibular deafferentation in rats are probably permanent. Neurobiology of Learning & Memory, 94(3), 402-413. doi: 10.1016/j.nlm.2010.08.007
Journal - Research Article
Goddard, M., Smith, P. F., & Ashton, J. C. (2010). Behavioural effects of co-administration of Δ9-tetrahydrocannabinol with fluoxetine in rats. Pharmacology, 86(2), 125-128. doi: 10.1159/000317059
Journal - Research Article
Liu, P., Zhang, H., Devaraj, R., Ganesalingam, G., & Smith, P. F. (2010). A multivariate analysis of the effects of aging on glutamate, GABA and arginine metabolites in the rat vestibular nucleus. Hearing Research, 269(1-2), 122-133. doi: 10.1016/j.heares.2010.06.019
Journal - Research Article
Smith, P. F. (2010). New approaches in the management of spasticity in multiple sclerosis patients: Role of cannabinoids. Therapeutics & Clinical Risk Management, 6, 59-63.
Journal - Research Article
Smith, P. F., & Darlington, C. L. (2010). A possible explanation for dizziness following SSRI discontinuation. Acta Oto-Laryngologica, 130, 981-983. doi: 10.3109/00016481003602082
Journal - Research Article
Zheng, Y., Mason-Parker, S. E., Logan, B., Darlington, C. L., Smith, P. F., & Abraham, W. C. (2010). Hippocampal synaptic transmission and LTP in vivo are intact following bilateral vestibular deafferentation in the rat. Hippocampus, 20(4), 461-468. doi: 10.1002/hipo.20645
Journal - Research Article
Zheng, Y., Masumura, C., Chung, P., Darlington, C. L., & Smith, P. F. (2010). Cell proliferation and survival in the vestibular nucleus following bilateral vestibular deafferentation in the adult rat. Neuroscience Letters, 468(1), 85-88. doi: 10.1016/j.neulet.2009.10.070
Journal - Research Article
Zheng, Y., Stiles, L., Hamilton, E., Smith, P. F., & Darlington, C. L. (2010). The effects of the synthetic cannabinoid receptor agonists, WIN55,212-2 and CP55,940, on salicylate-induced tinnitus in rats. Hearing Research, 268(1-2), 145-150. doi: 10.1016/j.heares.2010.05.015
Journal - Research Article
Zheng, Y., Vagal, S., Zhu, X.-X., de Waele, C., Smith, P. F., Wang, G., Zhang, M., & Darlington, C. L. (2010). The effects of the Chinese herbal medicine EMF01 on salicylate-induced tinnitus in rats. Journal of Ethnopharmacology, 128(2), 545-548. doi: 10.1016/j.jep.2010.01.053
Journal - Research Article