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Dr David Finlay

PositionPostdoctoral Fellow
DepartmentDepartment of Pharmacology and Toxicology
QualificationsBSc PGDipSci MSc(Hons) PhD
Research summaryCannabinoids, G protein-coupled receptors, cell signalling, molecular pharmacology, receptor theory

Research

My research area of interest is the molecular pharmacology of cannabinoid receptors and their ligands. The focus of my recent PhD research was non-canonical CB1 signalling, and the functional selectivity of CB1 agonists (the ability of different drugs to preferentially activate different signalling pathways). This is underpinned by a broader interest in disease aetiology and drug discovery as they relate to the function of G protein-coupled receptors (of which the cannabinoid receptors are an example). I also have an interest in receptor theory and participate in collaborations in this area.

Current projects involve research into the molecular characteristics of synthetic cannabinoids. These are a rapidly proliferating class of drugs of abuse (including in New Zealand), which are of increasing concern because of their negative social effects and physiological toxicity – for example, AMB-FUBINACA is a synthetic cannabinoid now believed to be involved in the deaths of several dozen New Zealanders. The mechanism(s) by which these compounds exert their toxic effects is currently unknown.

Publications

Markham, J., Sparkes, E., Boyd, R., Chen, S., Manning, J. J., Finlay, D., … Glass, M., … Banister, S. D. (2022). Defining steric requirements at CB1 and CB2 cannabinoid receptors using synthetic cannabinoid receptor agonists 5F-AB-PINACA, 5F-ADB-PINACA, PX-1, PX-2, NNL-1, and their analogues. ACS Chemical Neuroscience, 13, 1281-1295. doi: 10.1021/acschemneuro.2c00034

Finlay, D. B., Nguyen, T., Gamage, T. F., Chen, S., Barrus, D. G., Patel, P. R., … Glass, M. (2022). Exploring determinants of agonist efficacy at the CB1 cannabinoid receptor: Analogues of the synthetic cannabinoid receptor agonist EG-018. Pharmacology Research & Perspectives, 10, e00901. doi: 10.1002/prp2.901

Patel, M., Matti, C., Grimsey, N. L., Legler, D. F., Javitch, J. A., Finlay, D. B., & Glass, M. (2021). Delineating the interactions between the cannabinoid CB2 receptor and its regulatory effectors: β‐arrestins and GPCR kinases. British Journal of Pharmacology, 179, 2223-2239. doi: 10.1111/bph.15748

Nguyen, T., Gamage, T. F., Finlay, D. B., Decker, A. M., Langston, T. L., Barrus, D., Glass, M., … Zhang, Y. (2021). Development of 3-(4-chlorophenyl)-1-(phenethyl)urea analogues as allosteric modulators of the cannabinoid type-1 receptor: RTICBM-189 is brain penetrant and attenuates reinstatement of cocaine-seeking behavior. Journal of Medicinal Chemistry. Advance online publication. doi: 10.1021/acs.jmedchem.1c01432

Yang, L., Zhu, X., Finlay, D. B., Glass, M., & Duffull, S. B. (2021). Exploring group size for statistical analysis of real-time signalling experiments. British Journal of Pharmacology. Advance online publication. doi: 10.1111/bph.15572

Hunter, M. R., Finlay, D. B., & Glass, M. (2017). Signal transduction and regulation of the cannabinoid CB1 receptor. In V. R. Preedy (Ed.), Handbook of cannabis and related pathologies: Biology, pharmacology, diagnosis, and treatment. (pp. 563-572). London, UK: Academic Press. doi: 10.1016/B978-0-12-800756-3.00069-7

Chapter in Book - Research

Hunter, M. R., Finlay, D. B., Macdonald, C. E., Cawston, E. E., Grimsey, N. L., & Glass, M. (2017). Real-time measurement of cannabinoid receptor-mediated cAMP signaling. In P. H. Reggio (Ed.), Methods in enzymology: Cannabinoids and their receptors (Vol. 593). (pp. 43-59). Cambridge, MA: Academic Press. doi: 10.1016/bs.mie.2017.05.001

Chapter in Book - Research

Finlay, D. B., Nguyen, T., Gamage, T. F., Chen, S., Barrus, D. G., Patel, P. R., … Glass, M. (2022). Exploring determinants of agonist efficacy at the CB1 cannabinoid receptor: Analogues of the synthetic cannabinoid receptor agonist EG-018. Pharmacology Research & Perspectives, 10, e00901. doi: 10.1002/prp2.901

Journal - Research Article

Markham, J., Sparkes, E., Boyd, R., Chen, S., Manning, J. J., Finlay, D., … Glass, M., … Banister, S. D. (2022). Defining steric requirements at CB1 and CB2 cannabinoid receptors using synthetic cannabinoid receptor agonists 5F-AB-PINACA, 5F-ADB-PINACA, PX-1, PX-2, NNL-1, and their analogues. ACS Chemical Neuroscience, 13, 1281-1295. doi: 10.1021/acschemneuro.2c00034

Journal - Research Article

Manning, J. J., Green, H. M., Glass, M., & Finlay, D. B. (2021). Pharmacological selection of cannabinoid receptor effectors: Signalling, allosteric modulation and bias. Neuropharmacology. Advance online publication. doi: 10.1016/j.neuropharm.2021.108611

Journal - Research Article

Mielnik, C. A., Sugamori, K. S., Finlay, D. B., Thorpe, H. H. A., Schapira, M., Sivananthan, N., … Glass, M., … Ross, R. A. (2021). A novel allosteric modulator of the cannabinoid CB1 receptor ameliorates hyperdopaminergia endophenotypes in rodent models. Neuropsychopharmacology, 46, 413-422. doi: 10.1038/s41386-020-00876-5

Journal - Research Article

Nguyen, T., Gamage, T. F., Decker, A. M., Finlay, D. B., Langston, T. L., Barrus, D., Glass, M., … Zhang, Y. (2021). Rational design of cannabinoid type-1 receptor allosteric modulators: Org27569 and PSNCBAM-1 hybrids. Bioorganic & Medicinal Chemistry. Advance online publication. doi: 10.1016/j.bmc.2021.116215

Journal - Research Article

Nguyen, T., Gamage, T. F., Finlay, D. B., Decker, A. M., Langston, T. L., Barrus, D., Glass, M., … Zhang, Y. (2021). Development of 3-(4-chlorophenyl)-1-(phenethyl)urea analogues as allosteric modulators of the cannabinoid type-1 receptor: RTICBM-189 is brain penetrant and attenuates reinstatement of cocaine-seeking behavior. Journal of Medicinal Chemistry. Advance online publication. doi: 10.1021/acs.jmedchem.1c01432

Journal - Research Article

Patel, M., Finlay, D. B., & Glass, M. (2021). Biased agonism at the cannabinoid receptors: Evidence from synthetic cannabinoid receptor agonists. Cellular Signaling, 78, 109865. doi: 10.1016/j.cellsig.2020.109865

Journal - Research Article

Patel, M., Matti, C., Grimsey, N. L., Legler, D. F., Javitch, J. A., Finlay, D. B., & Glass, M. (2021). Delineating the interactions between the cannabinoid CB2 receptor and its regulatory effectors: β‐arrestins and GPCR kinases. British Journal of Pharmacology, 179, 2223-2239. doi: 10.1111/bph.15748

Journal - Research Article

Yang, L., Zhu, X., Finlay, D. B., Glass, M., & Duffull, S. B. (2021). Exploring group size for statistical analysis of real-time signalling experiments. British Journal of Pharmacology. Advance online publication. doi: 10.1111/bph.15572

Journal - Research Article

Finlay, D. B., Sircombe, K. J., Nimick, M., Jones, C., & Glass, M. (2020). Terpenoids from cannabis do not mediate an entourage effect by acting at cannabinoid receptors. Frontiers in Pharmacology, 11, 359. doi: 10.3389/fphar.2020.00359

Journal - Research Article

Gamage, T. F., Barrus, D. A., Kevin, R. C., Finlay, D. B., Lefever, T. W., Patel, P. R., … Glass, M., … Thomas, B. F. (2020). In vitro and in vivo pharmacological evaluation of the synthetic cannabinoid receptor agonist EG-018. Pharmacology Biochemistry & Behavior, 193, 172918. doi: 10.1016/j.pbb.2020.172918

Journal - Research Article

Patel, M., Manning, J. J., Finlay, D. B., Javitch, J. A., Banister, S. D., Grimsey, N. L., & Glass, M. (2020). Signalling profiles of a structurally diverse panel of synthetic cannabinoid receptor agonists. Biochemical Pharmacology, 175, 113871. doi: 10.1016/j.bcp.2020.113871

Journal - Research Article

Zhu, X., Finlay, D. B., Glass, M., & Duffull, S. B. (2020). Evaluation of the profiles of CB1 cannabinoid receptor signalling bias using joint kinetic modelling. British Journal of Pharmacology, 177, 3449-3463. doi: 10.1111/bph.15066

Journal - Research Article

Finlay, D. B., Manning, J. J., Ibsen, M. S., Macdonald, C. E., Patel, M., Javitch, J. A., … Glass, M. (2019). Do toxic synthetic cannabinoid receptor agonists have signature in vitro activity profiles? A case study of AMB-FUBINACA. ACS Chemical Neuroscience, 10, 4350-4360. doi: 10.1021/acschemneuro.9b00429

Journal - Research Article

Ibsen, M. S., Finlay, D. B., Patel, M., Javtich, J. A., Glass, M., & Grimsey, N. L. (2019). Cannabinoid CB1 and CB2 receptor-mediated arrestin translocation: Species, subtype, and agonist-dependence. Frontiers in Pharmacology, 10, 350. doi: 10.3389/fphar.2019.00350

Journal - Research Article

Zhu, X., Finlay, D. B., Glass, M., & Duffull, S. B. (2019). An intact model for quantifying functional selectivity. Scientific Reports, 9, 2557. doi: 10.1038/s41598-019-39000-z

Journal - Research Article

Zhu, X., Finlay, D. B., Glass, M., & Duffull, S. B. (2019). Model-free and kinetic modelling approaches for characterising non-equilibrium pharmacological pathway activity: Internalisation of cannabinoid CB1 receptors. British Journal of Pharmacology, 176, 2593-2607. doi: 10.1111/bph.14684

Journal - Research Article

Zhu, X., Finlay, D. B., Glass, M., & Duffull, S. B. (2018). An evaluation of the operational model when applied to quantify functional selectivity. British Journal of Pharmacology, 175, 1654-1668. doi: 10.1111/bph.14171

Journal - Research Article

Finlay, D. B., Cawston, E. E., Grimsey, N. L., Hunter, M. R., Korde, A., Vemuri, V. K., … Glass, M. (2017). Gαs signalling of the CB1 receptor and the influence of receptor number. British Journal of Pharmacology, 174(15), 2545-2562. doi: 10.1111/bph.13866

Journal - Research Article

Soethoudt, M., Grether, U., Fingerle, J., Grim, T. W., Fezza, F., de Petrocellis, L., … Finlay, D., … Glass, M., & van der Stelt, M. (2017). Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity. Nature Communications, 8, 13958. doi: 10.1038/ncomms13958

Journal - Research Article

Finlay, D. B., Joseph, W. R., Grimsey, N. L., & Glass, M. (2016). GPR18 undergoes a high degree of constitutive trafficking but is unresponsive to N-arachidonoyl glycine. PeerJ, 2016(4), e1835. doi: 10.7717/peerj.1835

Journal - Research Article

MacDonald, C., Finlay, D. B., Jabed, A., Glass, M., & Graham, E. S. (2014). Development of positive control tissue for in situ hybridisation using Alvetex scaffolds. Journal of Neuroscience Methods, 238, 70-77. doi: 10.1016/j.jneumeth.2014.09.006

Journal - Research Article

Finlay, D. B., Duffull, S. B., & Glass, M. (2020). 100 years of modelling ligand-receptor binding and response: A focus on GPCRs. British Journal of Pharmacology, 177, 1472-1484. doi: 10.1111/bph.14988

Journal - Research Other

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