Dr Anurag Singh
| Position | Research Fellow |
|---|---|
| Department | Department of Pharmacology and Toxicology |
| Qualifications | MSc PhD |
| Research summary | Auditory-limbic interaction in tinnitus generation and perception |
| Memberships |
|
Research
Tinnitus, a complex disorder, results from sentient cognisance of a sound without an external auditory stimulus. It is reported in children, adults, and older populations. Patients suffering from tinnitus often present with hearing loss, anxiety, depression, and sleep disruption in addition to hissing and ringing in the ear.
Human imaging study shows that tinnitus affects both auditory and limbic regions, and the interplay between the auditory-limbic system may be central to understanding and perhaps therapeutics for persistent tinnitus.
Using electrophysiological, imaging and behavioural approaches in rodents, my research brings attention to the role of synaptic plasticity in the limbic system such as the hippocampus, amygdala and others (and its interaction with the auditory system) in tinnitus development.
Publications
Singh, A., Sateesh, S., Jones, O. D., & Abraham, W. C. (2022). Pathway-specific TNF-mediated metaplasticity in hippocampal area CA1. Scientific Reports, 12, 1746. doi: 10.1038/s41598-022-05844-1
Livingstone, R. W., Elder, M. K., Singh, A., Westlake, C. M., Tate, W. P., Abraham, W. C., & Williams, J. M. (2021). Secreted amyloid precursor protein-alpha enhances LTP through the synthesis and trafficking of Ca2+-permeable AMPA receptors. Frontiers in Molecular Neuroscience, 14, 660208. doi: 10.3389/fnmol.2021.660208
Singh, A., Jones, O. D., Mockett, B. G., Ohline, S. M., & Abraham, W. C. (2019). Tumor necrosis factor-α-mediated metaplastic inhibition of LTP is constitutively engaged in an Alzheimer's disease model. Journal of Neuroscience, 39(46), 9083-9097. doi: 10.1523/jneurosci.1492-19.2019
Morrissey, J. A., Mockett, B. G., Singh, A., Kweon, D., Ohline, S. M., Tate, W. P., Hughes, S. M., & Abraham, W. C. (2019). A C-terminal peptide from secreted amyloid precursor protein-α enhances long-term potentiation in rats and a transgenic mouse model of Alzheimer's disease. Neuropharmacology, 157, 107670. doi: 10.1016/j.neuropharm.2019.107670
Mockett, B. G., Guévremont, D., Elder, M. K., Parfitt, K. D., Peppercorn, K., Morrissey, J., Singh, A., Hintz, T. J., … Tate, W. P., Williams, J. M., & Abraham, W. C. (2019). Glutamate receptor trafficking and protein synthesis mediate the facilitation of LTP by secreted amyloid precursor protein-alpha. Journal of Neuroscience, 39(17), 3188-3203. doi: 10.1523/jneurosci.1826-18.2019
Singh, A., Sateesh, S., Jones, O. D., & Abraham, W. C. (2022). Pathway-specific TNF-mediated metaplasticity in hippocampal area CA1. Scientific Reports, 12, 1746. doi: 10.1038/s41598-022-05844-1
Journal - Research Article
Livingstone, R. W., Elder, M. K., Singh, A., Westlake, C. M., Tate, W. P., Abraham, W. C., & Williams, J. M. (2021). Secreted amyloid precursor protein-alpha enhances LTP through the synthesis and trafficking of Ca2+-permeable AMPA receptors. Frontiers in Molecular Neuroscience, 14, 660208. doi: 10.3389/fnmol.2021.660208
Journal - Research Article
Mockett, B. G., Guévremont, D., Elder, M. K., Parfitt, K. D., Peppercorn, K., Morrissey, J., Singh, A., Hintz, T. J., … Tate, W. P., Williams, J. M., & Abraham, W. C. (2019). Glutamate receptor trafficking and protein synthesis mediate the facilitation of LTP by secreted amyloid precursor protein-alpha. Journal of Neuroscience, 39(17), 3188-3203. doi: 10.1523/jneurosci.1826-18.2019
Journal - Research Article
Morrissey, J. A., Mockett, B. G., Singh, A., Kweon, D., Ohline, S. M., Tate, W. P., Hughes, S. M., & Abraham, W. C. (2019). A C-terminal peptide from secreted amyloid precursor protein-α enhances long-term potentiation in rats and a transgenic mouse model of Alzheimer's disease. Neuropharmacology, 157, 107670. doi: 10.1016/j.neuropharm.2019.107670
Journal - Research Article
Singh, A., Jones, O. D., Mockett, B. G., Ohline, S. M., & Abraham, W. C. (2019). Tumor necrosis factor-α-mediated metaplastic inhibition of LTP is constitutively engaged in an Alzheimer's disease model. Journal of Neuroscience, 39(46), 9083-9097. doi: 10.1523/jneurosci.1492-19.2019
Journal - Research Article
Singh, A., & Abraham, W. C. (2017). Astrocytes and synaptic plasticity in health and disease. Experimental Brain Research, 235(6), 1645-1655. doi: 10.1007/s00221-017-4928-1
Journal - Research Article
Gautam, M., Prasoon, P., Kumar, R., Singh, A., Shrimal, P., & Ray, S. B. (2016). Direct intrawound administration of dimethylsulphoxide relieves acute pain in rats. International Wound Journal, 13, 252-256. doi: 10.1111/iwj.12280
Journal - Research Article
George, J., Pulickal, S. J., Singh, A., Gautam, M., Prasoon, P., Kumar, R., & Ray, S. B. (2014). Locally mediated analgesic effect of bradykinin type 2 receptor antagonist HOE 140 during acute inflammatory pain in rats. Journal of Burn Care & Research, 35, e391-e398. doi: 10.1097/BCR.0000000000000042
Journal - Research Article
