Accessibility Skip to Global Navigation Skip to Local Navigation Skip to Content Skip to Search Skip to Site Map Menu

Professor Daryl Schwenke

PositionProfessor
DepartmentDepartment of Physiology
QualificationsBSc(Hons) MSc PhD
Research summaryCardiorespiratory Physiology

Research

  • Sympathetic excitation following actute myocardial infarction
    • Therapeutic effects of ghrelin in acute heart failure
    • Role of the peripheral chemoreflex in sympathetic excitation
  • Regulation of the pulmonary vasculature
    • Endothelial control of the pulmonary vasculature
    • Sympathetic modulation
    • Pathological changes in the pathogenesis of pulmonary hypertension
    • Pulmonary vascular dysfunction in obesity

Publications

Schwenke, D. O., Pearson, J. T., Umetani, K., Kangawa, K., & Shirai, M. (2007). Imaging of the pulmonary circulation in the closed-chest rat using synchrotron radiation microangiography. Journal of Applied Physiology, 102, 787-793.

Schwenke, D. O., Gray, E. A., Pearson, J. T., Sonobe, T., Ishibashi-Ueda, H., Campillo, I., … Shirai, M. (2011). Exogenous ghrelin improves blood flow distribution in pulmonary hypertension: Assessed using synchrotron radiation microangiography. Pflügers Archiv: European Journal of Physiology, 462(3), 397-406. doi: 10.1007/s00424-011-0992-8

Schwenke, D. O., Pearson, J. T., Sonobe, T., Ishibashi-Ueda, H., Shimouchi, A., Kangawa, K., … Shirai, M. (2011). Role of Rho-kinase signaling and endothelial dysfunction in modulating blood flow distribution in pulmonary hypertension. Journal of Applied Physiology, 110(4), 901-908. doi: 10.1152/japplphysiol.01318.2010

Schwenke, D. O., Pearson, J. T., Shimochi, A., Kangawa, K., Tsuchimochi, H., Umetani, K., … Cragg, P. A. (2009). Changes in pulmonary blood flow distribution in monocrotaline compared with hypoxia-induced models of pulmonary hypertension: Assessed using synchrotron radiation. Journal of Hypertension, 27(7), 1410-1419. doi: 10.1097/HJH.0b013e32832af6a1

Sonobe, T., Schwenke, D. O., Pearson, J. T., Yoshimoto, M., Fujii, Y., Umetani, K., & Shirai, M. (2011). Imaging of the closed-chest mouse pulmonary circulation using synchrotron radiation microangiography. Journal of Applied Physiology, 111(1), 75-80. doi: 10.1152/japplphysiol.00205.2011

Schwenke, D. O., Pearson, J. T., Umetani, K., Kangawa, K., & Shirai, M. (2007). Imaging of the pulmonary circulation in the closed-chest rat using synchrotron radiation microangiography. Journal of Applied Physiology, 102, 787-793.

Journal - Research Article

Schwenke, D. O., Gray, E. A., Pearson, J. T., Sonobe, T., Ishibashi-Ueda, H., Campillo, I., … Shirai, M. (2011). Exogenous ghrelin improves blood flow distribution in pulmonary hypertension: Assessed using synchrotron radiation microangiography. Pflügers Archiv: European Journal of Physiology, 462(3), 397-406. doi: 10.1007/s00424-011-0992-8

Journal - Research Article

Schwenke, D. O., Pearson, J. T., Sonobe, T., Ishibashi-Ueda, H., Shimouchi, A., Kangawa, K., … Shirai, M. (2011). Role of Rho-kinase signaling and endothelial dysfunction in modulating blood flow distribution in pulmonary hypertension. Journal of Applied Physiology, 110(4), 901-908. doi: 10.1152/japplphysiol.01318.2010

Journal - Research Article

Schwenke, D. O., Pearson, J. T., Shimochi, A., Kangawa, K., Tsuchimochi, H., Umetani, K., … Cragg, P. A. (2009). Changes in pulmonary blood flow distribution in monocrotaline compared with hypoxia-induced models of pulmonary hypertension: Assessed using synchrotron radiation. Journal of Hypertension, 27(7), 1410-1419. doi: 10.1097/HJH.0b013e32832af6a1

Journal - Research Article

Sonobe, T., Schwenke, D. O., Pearson, J. T., Yoshimoto, M., Fujii, Y., Umetani, K., & Shirai, M. (2011). Imaging of the closed-chest mouse pulmonary circulation using synchrotron radiation microangiography. Journal of Applied Physiology, 111(1), 75-80. doi: 10.1152/japplphysiol.00205.2011

Journal - Research Article

Pearson, J. T., Schwenke, D. O., Jenkins, M. J., Edgley, A. J., Sonobe, T., Ishibashi-Ueda, H., … Shirai, M. (2010). Benefits of synchrotron microangiography for dynamic studies of smooth muscle and endothelial roles in the pathophysiology of vascular disease. AIP Conference Proceedings, 1266(1), 84-88. doi: 10.1063/1.3478204

Journal - Research Article

Schwenke, D. O., Pearson, J. T., Kangawa, K., Cragg, P. A., & Shirai, M. (2010). Exogenous ghrelin accentuates the acute hypoxic ventilatory response after two weeks of chronic hypoxia in conscious rats. Acta Physiologica, 200(3), 279-287. doi: 10.1111/j.1748-1716.2010.02142.x

Journal - Research Article

Shirai, M., Schwenke, D. O., Eppel, G. A., Evans, R. G., Edgley, A. J., Tsuchimochi, H., … Pearson, J. T. (2009). Synchrotron-based angiography for investigation of the regulation of vasomotor function in the microcirculation in vivo. Clinical & Experimental Pharmacology & Physiology, 36(1), 107-116. doi: 10.1111/j.1440-1681.2008.05073.x

Journal - Research Article

Kishimoto, I., Tokudome, T., Schwenke, D. O., Takeshi, S., Hosoda, H., Nagaya, N., & Kangawa, K. (2009). Therapeutic potential of ghrelin in cardiac diseases. Expert Review of Endocrinology & Metabolism, 4(3), 283-289.

Journal - Research Article

Schwenke, D. O., Pearson, J. T., Kangawa, K., Umetani, K., & Shirai, M. (2008). Changes in macrovessel pulmonary blood flow distribution following chronic hypoxia: Assessed using synchrotron radiation microangiography. Journal of Applied Physiology, 104(1), 88-96.

Journal - Research Article

Schwenke, D. O., Tokudome, T., Kishimoto, I., Horio, T., Shirai, M., Cragg, P. A., & Kangawa, K. (2008). Early ghrelin treatment after myocardial infarction prevents an increase in cardiac sympathetic tone and reduces mortality. Endocrinology, 149(10), 5172-5176.

Journal - Research Article

Schwenke, D. O., Tokudome, T., Shirai, M., Hosoda, H., Horio, T., Kishimoto, I., & Kangawa, K. (2008). Exogenous ghrelin attenuates the progression of chronic hypoxia-induced pulmonary hypertension in conscious rats. Endocrinology, 149(1), 237-244.

Journal - Research Article

Schwenke, D. O., Bolter, C. P., & Cragg, P. A. (2007). Are the carotid bodies of the guinea-pig functional? Comparative Biochemistry & Physiology Part A, 146(2), 180-188.

Journal - Research Article

Pearson, J. T., Shirai, M., Tsuchimochi, H., Schwenke, D. O., Ishida, T., Kangawa, K., … Yagi, N. (2007). Effects of sustained length-dependent activiation on in situ cross-bridge dynamics in rat hearts. Biophysical Journal, 93, 4319-4329.

Journal - Research Article

Schwenke, D. O., Pearson, J. T., Tsuchimochi, H., Kangawa, K., & Shirai, M. (2007). Pulmonary vascular reactivity of spontaneously hypertensive rats is exacerbated in response to the central administration of exogenous nitrix oxide. Clinical & Experimental Pharmacology & Physiology, 34, 88-94.

Journal - Research Article

Pearson, J. T., Shirai, M., Yokoyama, C., Tsuchimochi, H., Schwenke, D. O., Shimouchi, A., … Tanabe, T. (2007). α2-Adrenoreceptor mediated sympathoinhibition of heart rate during acute hypoxia is diminished in conscious prostacyclin synthase deficient mice. Pflügers Archiv: European Journal of Physiology, 454, 29-39. doi: 10.1007/s00424-006-0175-1

Journal - Research Article

Schwenke, D. O., Pearson, J. T., Kangawa, K., & Shirai, M. (2006). Does central nitric oxide chronically modulate the acute hypoxic ventilatory response in conscious rats? Acta Physiologica, 186, 309-318.

Journal - Research Article

Schwenke, D. O., Pearson, J. T., Mori, H., & Shirai, M. (2006). Does central nitric oxide elicit pulmonary hypertension in conscious rats? Respiratory Physiology & Neurobiology, 153, 250-260.

Journal - Research Article

Schwenke, D. O., Pearson, J. T., Mori, H., & Shirai, M. (2006). Long-term monitoring of pulmonary arterial pressure in conscious, unrestrained mice. Journal of Pharmacological & Toxicological Methods, 53, 277-283.

Journal - Research Article

More publications...