Dr Anne von Zychlinski-Kleffman
| Position | Research Fellow |
|---|---|
| Department | Department of Biochemistry |
| Qualifications | PhD |
| Research summary | Proteomics and inhibition of lipoprotein(a) |
Research
Inhibition of lipoprotein (a) formation. Elevated Lp(a) is associated with the development of cardiovascular diseases. To date no therapy that effectively lowers Lp(a) exists. We have screened different compounds for Lp(a) inhibitory activity and so far identified bacitracin, an old peptide antibiotic and DMPC as inhibitors for Lp(a) assembly. Also, proteomic analysis of lipoproteins in human plasma.Publications
Lassé, M., Pilbrow, A. P., Kleffmann, T., Andersson Överström, E., von Zychlinski, A., Frampton, C. M. A., … Troughton, R. W., Lewis, L. K., Prickett, T. C. R., Pemberton, C. J., Richards, A. M., & Cameron, V. A. (2021). Fibrinogen and hemoglobin predict near future cardiovascular events in asymptomatic individuals. Scientific Reports, 11(1), 4605. doi: 10.1038/s41598-021-84046-7
Sharma, M., Von Zychlinski-Kleffmann, A., Porteous, C. M., Jones, G. T., Williams, M. J. A., & McCormick, S. P. A. (2015). Lipoprotein (a) upregulates ABCA1 in liver cells via scavenger receptor-B1 through its oxidized phospholipids. Journal of Lipid Research, 56, 1318-1328. doi: 10.1194/jlr.M056150
von Zychlinski, A., & Kleffmann, T. (2015). Dissecting the proteome of lipoproteins: New biomarkers for cardiovascular diseases? Translational Proteomics, 7, 30-39. doi: 10.1016/j.trprot.2014.12.001
von Zychilinski, A., Williams, M., McCormick, S., & Kleffmann, T. (2014). Absolute quantification of apolipoproteins and associated proteins on human plasma lipoproteins. Journal of Proteomics, 106, 181-190. doi: 10.1016/j.jprot.2014.04.030
von Zychlinski, A., Kleffmann, T., Williams, M. J. A., & McCormick, S. P. (2011). Proteomics of Lipoprotein(a) identifies a protein complement associated with response to wounding. Journal of Proteomics, 74, 2881-2891. doi: 10.1016/j.jprot.2011.07.008
von Zychlinski, A., & Gruissem, W. (2009). Preparation and analysis of plastid proteomes by 2DE. In D. Sheehan & R. Tyther (Eds.), Two-dimensional electrophoresis protocols: Methods in molecular biology (Vol. 519). (pp. 205-220). Totowa, NJ: Humana Press. doi: 10.1007/978-1-59745-281-6_13
Chapter in Book - Research
von Zychilinski, A., Reiland, S., Gruissem, W., & Baginsky, S. (2008). Etioplast. In G. K. Agrawal & R. Rakwal (Eds.), Plant Proteomics: Technologies, strategies, and applications. (pp. 351-360). Hoboken, NJ: John Wiley & Sons. doi: 10.1002/9780470369630.ch24
Chapter in Book - Research
Lassé, M., Pilbrow, A. P., Kleffmann, T., Andersson Överström, E., von Zychlinski, A., Frampton, C. M. A., … Troughton, R. W., Lewis, L. K., Prickett, T. C. R., Pemberton, C. J., Richards, A. M., & Cameron, V. A. (2021). Fibrinogen and hemoglobin predict near future cardiovascular events in asymptomatic individuals. Scientific Reports, 11(1), 4605. doi: 10.1038/s41598-021-84046-7
Journal - Research Article
Sharma, M., Von Zychlinski-Kleffmann, A., Porteous, C. M., Jones, G. T., Williams, M. J. A., & McCormick, S. P. A. (2015). Lipoprotein (a) upregulates ABCA1 in liver cells via scavenger receptor-B1 through its oxidized phospholipids. Journal of Lipid Research, 56, 1318-1328. doi: 10.1194/jlr.M056150
Journal - Research Article
von Zychlinski, A., & Kleffmann, T. (2015). Dissecting the proteome of lipoproteins: New biomarkers for cardiovascular diseases? Translational Proteomics, 7, 30-39. doi: 10.1016/j.trprot.2014.12.001
Journal - Research Article
von Zychilinski, A., Williams, M., McCormick, S., & Kleffmann, T. (2014). Absolute quantification of apolipoproteins and associated proteins on human plasma lipoproteins. Journal of Proteomics, 106, 181-190. doi: 10.1016/j.jprot.2014.04.030
Journal - Research Article
von Zychlinski, A., Kleffmann, T., Williams, M. J. A., & McCormick, S. P. (2011). Proteomics of Lipoprotein(a) identifies a protein complement associated with response to wounding. Journal of Proteomics, 74, 2881-2891. doi: 10.1016/j.jprot.2011.07.008
Journal - Research Article
Wang, Y.-T., von Zychlinski, A., & McCormick, S. P. A. (2009). Dimyristoylphosphotidylcholine induces conformational changes in apoB that lowers lipoprotein(a). Journal of Lipid Research, 50(5), 846-853. doi: 10.1194/jlr.M800428-JLR200
Journal - Research Article
Kleffmann, T., von Zychlinski, A., Russenberger, D., Hirsch-Hoffmann, M., Gehrig, P., Gruissem, W., & Baginsky, S. (2007). Proteome dynamics during plastid differentiation in rice. Plant Physiology, 143, 912-923. doi: 10.1104/pp.106.090738
Journal - Research Article
Baginsky, S., Kleffmann, T., von Zychlinski, A., & Gruissem, W. (2005). Analysis of shotgun proteomics and RNA profiling data from Arabidopsis thaliana chloroplasts. Journal of Proteome Research, 4(2), 637-640.
Journal - Research Article
von Zychilinski, A., Kleffmann, T., Krishnamurthy, N., Sjolander, K., Baginsky, S., & Gruissem, W. (2005). Proteome analysis of the rice etioplast: Metabolic and regulatory networks and novel protein functions. Molecular & Cellular Proteomics, 4(8), 1072-1084.
Journal - Research Article
Kleffmann, T., Russenberger, D., von Zychilinski, A., Sjolander, K., Gruissem, W., & Baginsky, S. (2004). The arabidopsis thaliana chloroplast proteome reveals pathway abundance and novel protein functions. Current Biology, 14, 354-362.
Journal - Research Article
