Dr Zoe Ashley
Position | Lecturer |
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Department | Department of Physiology |
Qualifications | PhD |
Research summary | Understanding atherosclerosis |
Teaching | Physiology |
Memberships |
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Research
My research focus is in vascular biology, particularly atherosclerosis.
My current research projects are investigating the role of Calcium calmodulin kinase II (CaMKII) and Klotho in the development of atherosclerotic lesions in the ApoE -/- mouse model.
My research questions whether these proteins are important in the development of the disease. I am determining whether changing levels of these proteins reduces the progression of atherosclerotic lesions, either in terms of lesion size, stenosis, severity and morphology. In addition, these projects also examine sex-differences in atherosclerotic disease.
Overall research findings could highlight a potential pathway for the development of new therapies for the major underlying cause of cardiovascular disease.
Publications
Ashley, Z., Futi, T., Van Hout, I., Coffey, S., Schwenke, D. O., Bahn, A., & Lamberts, R. R. (2022). Cardiac fibrosis in right atrial tissue is not different in male Pasifika and Pākehā cardiac surgery patients in Aotearoa. Pacific Journal of Medical Sciences, 22(2), 11-30.
Lund, R. A., Cooper, E. R., Wang, H., Ashley, Z., Cawley, A. T., & Heather, A. K. (2021). Non-targeted detection of designer androgens: Underestimated role of in vitro bioassays. Drug Testing & Analysis. Advance online publication. doi: 10.1002/dta.3049
Cooper, E. R., Hughes, G., Kauff, A., Sutherland, E., Ashley, Z., & Heather, A. K. (2021). A cell-free bioassay for the detection of androgens. Drug Testing & Analysis. Advance online publication. doi: 10.1002/dta.3024
Gillon, A., Ho, E. N. M., Chan, G. H. M., Kauff, A., Hughes, G., Lund, R. A., Ashley, Z., … Heather, A. K. (2021). Unravelling androgens in sport: Altrenogest shows strong activation of the androgen receptor in a mammalian cell bioassay. Drug Testing & Analysis, 13, 523-528. doi: 10.1002/dta.2941
Ebenebe, O. V., Ashley, Z., Erickson, J. R., & Heather, A. K. (2020). A timing effect of 17-β estradiol on atherosclerotic lesion development in female ApoE−/− mice. International Journal of Molecular Sciences, 21(13), 4710. doi: 10.3390/ijms21134710
Ashley, Z., Futi, T., Van Hout, I., Coffey, S., Schwenke, D. O., Bahn, A., & Lamberts, R. R. (2022). Cardiac fibrosis in right atrial tissue is not different in male Pasifika and Pākehā cardiac surgery patients in Aotearoa. Pacific Journal of Medical Sciences, 22(2), 11-30.
Journal - Research Article
Cooper, E. R., Hughes, G., Kauff, A., Sutherland, E., Ashley, Z., & Heather, A. K. (2021). A cell-free bioassay for the detection of androgens. Drug Testing & Analysis. Advance online publication. doi: 10.1002/dta.3024
Journal - Research Article
Gillon, A., Ho, E. N. M., Chan, G. H. M., Kauff, A., Hughes, G., Lund, R. A., Ashley, Z., … Heather, A. K. (2021). Unravelling androgens in sport: Altrenogest shows strong activation of the androgen receptor in a mammalian cell bioassay. Drug Testing & Analysis, 13, 523-528. doi: 10.1002/dta.2941
Journal - Research Article
Ebenebe, O. V., Ashley, Z., Erickson, J. R., & Heather, A. K. (2020). A timing effect of 17-β estradiol on atherosclerotic lesion development in female ApoE−/− mice. International Journal of Molecular Sciences, 21(13), 4710. doi: 10.3390/ijms21134710
Journal - Research Article
Knoepp, F., Ashley, Z., Barth, D., Baldin, J.-P., Jennings, M., Kazantseva, M., Saw, E. L., Katare, R., … Fronius, M. (2020). Shear force sensing of epithelial Na+ channel (ENaC) relies on N-glycosylated asparagines in the palm and knuckle domains of αENaC. PNAS, 117(1), 717-726. doi: 10.1073/pnas.1911243117
Journal - Research Article
Ashley, Z., Mugloo, S., McDonald, F. J., & Fronius, M. (2018). Epithelial Na+ channel differentially contributes to shear stress-mediated vascular responsiveness in carotid and mesenteric arteries from mice. American Journal of Physiology: Heart & Circulatory Physiology, 314(5), H1022-H1032. doi: 10.1152/ajpheart.00506.2017
Journal - Research Article
Ashley, Z., Schwenke, D. O., & Cragg, P. A. (2015). Hyperventilation in normoxia following myocardial infarction in rats: A shift in the set point of the hypoxic ventilatory response. Acta Physiologica, 214, 415-425. doi: 10.1111/apha.12527
Journal - Research Article
Bussey, C. T., de Leeuw, A. E., Cook, R. F., Ashley, Z., Schofield, J., & Lamberts, R. R. (2014). Dual implantation of a radio-telemeter and vascular access port allows repeated hemodynamic and pharmacological measures in conscious lean and obese rats. Laboratory Animals, 48(3), 250-260. doi: 10.1177/0023677214530687
Journal - Research Article
Russold, M. F., Ramnarine, I., Ashley, Z., Sutherland, H., Salmons, S., & Jarvis, J. C. (2010). Practical and effective stomal sphincter creation: Evaluation in pigs. Diseases of the Colon & Rectum, 53(4), 467-474. doi: 10.1007/DCR.0b013e3181bdbe91
Journal - Research Article
Ashley, Z., Sutherland, H., Russold, M. F., Lanmüller, H., Mayr, W., Jarvis, J. C., & Salmons, S. (2008). Therapeutic stimulation of denervated muscles: The influence of pattern. Muscle & Nerve, 38, 875-886. doi: 10.1002/mus.21020
Journal - Research Article
Ashley, Z., Salmons, S., Boncompagni, S., Protasi, F., Russold, M., Lanmuller, H., … Jarvis, J. C. (2007). Effects of chronic electrical stimulation on long-term denervated muscles of the rabbit hind limb. Journal of Muscle Research & Cell Motility, 28, 203-217. doi: 10.1007/s10974-007-9119-4
Journal - Research Article
Ashley, Z., Sutherland, H., Lanmüller, H., Russold, M. F., Unger, E., Bijak, M., … Jarvis, J. C. (2007). Atrophy, but not necrosis, in rabbit skeletal muscle denervated for periods up to one year. American Journal of Physiology: Cell Physiology, 292, C440-C451. doi: 10.1152/ajpcell.00085.2006
Journal - Research Article
Chilcott, R. P., Dalton, C. H., Ashley, Z., Allen, C. E., Bradley, S. T., ..., & Rice, P. (2007). Evaluation of barrier creams against sulphur mustard: (II) in vivo and in vitro studies using the domestic white pig. Cutaneous & Ocular Toxicology, 26, 235-247. doi: 10.1080/15569520701212373
Journal - Research Article
Ramnarine, I. R., Capoccia, M., Ashley, Z., Sutherland, H., Russold, M., Summerfield, N., … Jarvis, J. C. (2006). Counterpulsation from the skeletal muscle ventricle and the intraaortic balloon pump in the normal and failing circulations. Circulation, 114(Suppl. I), I-10-I-15. doi: 10.1161/CIRCULATIONAHA.105.000372
Journal - Research Article
Lund, R. A., Cooper, E. R., Wang, H., Ashley, Z., Cawley, A. T., & Heather, A. K. (2021). Non-targeted detection of designer androgens: Underestimated role of in vitro bioassays. Drug Testing & Analysis. Advance online publication. doi: 10.1002/dta.3049
Journal - Research Other