Dr Zoe Ashley
| Position | Research Fellow |
|---|---|
| Department | Department of Physiology |
| Qualifications | PhD |
| Research summary | Role of ENaC in vascular biology |
| Memberships | European Society of Hypertension |
Research
Currently research active investigating the role of the Epithelial Sodium Channel (ENaC) as a potential 'new player' in the regulation of vascular tone and flow-mediated responses. Shear-sensation by ENaC is dependent on the interaction with the glycocalyx. Our research is investigating the molecular aspects of ENaC-matrix action and the functional role of vascular ENaC under both normal and pathophysiological (diabetes and hypertension) states.
Publications
Ashley, Z., Schwenke, D. O., & Cragg, P. A. (2015). Hyperventilation in normoxia following myocardial infarction in rats: A shift in the set point of the hypoxic ventilatory response. Acta Physiologica, 214, 415-425. doi: 10.1111/apha.12527
Bussey, C. T., de Leeuw, A. E., Cook, R. F., Ashley, Z., Schofield, J., & Lamberts, R. R. (2014). Dual implantation of a radio-telemeter and vascular access port allows repeated hemodynamic and pharmacological measures in conscious lean and obese rats. Laboratory Animals, 48(3), 250-260. doi: 10.1177/0023677214530687
Russold, M. F., Ramnarine, I., Ashley, Z., Sutherland, H., Salmons, S., & Jarvis, J. C. (2010). Practical and effective stomal sphincter creation: Evaluation in pigs. Diseases of the Colon & Rectum, 53(4), 467-474. doi: 10.1007/DCR.0b013e3181bdbe91
Ashley, Z., Sutherland, H., Russold, M. F., Lanmüller, H., Mayr, W., Jarvis, J. C., & Salmons, S. (2008). Therapeutic stimulation of denervated muscles: The influence of pattern. Muscle & Nerve, 38, 875-886. doi: 10.1002/mus.21020
Ashley, Z., Sutherland, H., Lanmüller, H., Russold, M. F., Unger, E., Bijak, M., … Jarvis, J. C. (2007). Atrophy, but not necrosis, in rabbit skeletal muscle denervated for periods up to one year. American Journal of Physiology: Cell Physiology, 292, C440-C451. doi: 10.1152/ajpcell.00085.2006
Journal - Research Article
Ashley, Z., Schwenke, D. O., & Cragg, P. A. (2015). Hyperventilation in normoxia following myocardial infarction in rats: A shift in the set point of the hypoxic ventilatory response. Acta Physiologica, 214, 415-425. doi: 10.1111/apha.12527
Bussey, C. T., de Leeuw, A. E., Cook, R. F., Ashley, Z., Schofield, J., & Lamberts, R. R. (2014). Dual implantation of a radio-telemeter and vascular access port allows repeated hemodynamic and pharmacological measures in conscious lean and obese rats. Laboratory Animals, 48(3), 250-260. doi: 10.1177/0023677214530687
Russold, M. F., Ramnarine, I., Ashley, Z., Sutherland, H., Salmons, S., & Jarvis, J. C. (2010). Practical and effective stomal sphincter creation: Evaluation in pigs. Diseases of the Colon & Rectum, 53(4), 467-474. doi: 10.1007/DCR.0b013e3181bdbe91
Ashley, Z., Sutherland, H., Russold, M. F., Lanmüller, H., Mayr, W., Jarvis, J. C., & Salmons, S. (2008). Therapeutic stimulation of denervated muscles: The influence of pattern. Muscle & Nerve, 38, 875-886. doi: 10.1002/mus.21020
Ashley, Z., Sutherland, H., Lanmüller, H., Russold, M. F., Unger, E., Bijak, M., … Jarvis, J. C. (2007). Atrophy, but not necrosis, in rabbit skeletal muscle denervated for periods up to one year. American Journal of Physiology: Cell Physiology, 292, C440-C451. doi: 10.1152/ajpcell.00085.2006
Ashley, Z., Salmons, S., Boncompagni, S., Protasi, F., Russold, M., Lanmuller, H., … Jarvis, J. C. (2007). Effects of chronic electrical stimulation on long-term denervated muscles of the rabbit hind limb. Journal of Muscle Research & Cell Motility, 28, 203-217. doi: 10.1007/s10974-007-9119-4
Chilcott, R. P., Dalton, C. H., Ashley, Z., Allen, C. E., Bradley, S. T., ..., & Rice, P. (2007). Evaluation of barrier creams against sulphur mustard: (II) in vivo and in vitro studies using the domestic white pig. Cutaneous & Ocular Toxicology, 26, 235-247. doi: 10.1080/15569520701212373
Ramnarine, I. R., Capoccia, M., Ashley, Z., Sutherland, H., Russold, M., Summerfield, N., … Jarvis, J. C. (2006). Counterpulsation from the skeletal muscle ventricle and the intraaortic balloon pump in the normal and failing circulations. Circulation, 114(Suppl. I), I-10-I-15. doi: 10.1161/CIRCULATIONAHA.105.000372
