Linda Buss, Research, Christchurch Heart Institute, University of Otago, New Zealand

Postdoctoral Fellow

Research interests

Dr Buss is currently establishing a method to grow heart muscle cells in the lab. This method will be used as a platform to investigate future research questions, including validating potential biomarkers of mild/moderate cardiac ischaemia that have been previously identified by our group.

Dr Buss is also interested in the intersection of the fields of heart disease and cancer (cardio-oncology), and aims to identify strategies to mitigate the adverse effects of cancer drugs on cardiovascular health.

Background

Dr Buss completed her PhD in the Department of Pathology and Biomedical Science at the University of Otago, Christchurch. Her PhD work focussed on how immunotherapy drugs modify the effect of exercise on cancer, and she joined the Christchurch Heart Institute in 2021, after completing her doctoral studies.

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Publications

Allan, J., Buss, L. A., Draper, N., & Currie, M. J. (2022). Exercise in people with cancer: A spotlight on energy regulation and cachexia. Frontiers in Physiology, 13, 836804. doi: 10.3389/fphys.2022.836804

Buss, L. A., Hock, B., Merry, T. L., Ang, A. D., Robinson, B. A., Currie, M. J., & Dachs, G. U. (2021). Effect of immune modulation on the skeletal muscle mitochondrial exercise response: An exploratory study in mice with cancer. PLoS ONE, 16(10), e0258831. doi: 10.1371/journal.pone.0258831

Buss, L. A., Williams, T., Hock, B., Ang, A. D., Robinson, B. A., Currie, M. J., & Dachs, G. U. (2021). Effects of exercise and anti-PD-1 on the tumour microenvironment. Immunology Letters, 239, 60-71. doi: 10.1016/j.imlet.2021.08.005

Buss, L. A., Dachs, G. U., Goddard, L., Ang, A. D., Robinson, B. A., Currie, M. J., & Hock, B. (2021). Is the immunogenicity of PD-1 blocking antibodies a confounding variable in murine studies? Immunology Letters, 234, 13-15. doi: 10.1016/j.imlet.2021.04.003

Buss, L. A. (2020). The immune system: A common link mediating exercise effects on the tumour microenvironment and skeletal muscle mitochondria? (PhD). University of Otago, Dunedin, New Zealand. Retrieved from http://hdl.handle.net/10523/10530

Buss, L. A., & Dachs, G. U. (2020). Effects of exercise on the tumour microenvironment. In A. Birbrair (Ed.), Tumor microenvironment: Recent advances. (pp. 31-51). Cham, Switzerland: Springer. doi: 10.1007/978-3-030-35727-6_3

Chapter in Book - Research

Journal - Research Article

Buss, L. A., Ang, A. D., Hock, B., Robinson, B. A., Currie, M. J., & Dachs, G. U. (2020). Effect of post-implant exercise on tumour growth rate, perfusion and hypoxia in mice. PLoS ONE, 15(3), e0229290. doi: 10.1371/journal.pone.0229290

Journal - Research Article

Buss, L. A., & Dachs, G. U. (2018). The role of exercise and hyperlipidaemia in breast cancer progression. Exercise Immunology Review, 24, 8-23.

Journal - Research Article

Buss, L. A., & Dachs, G. U. (2018). Voluntary exercise slows breast tumor establishment and reduces tumor hypoxia in ApoE^-/- mice. Journal of Applied Physiology, 124(4), 938-949. doi: 10.1152/japplphysiol.00738.2017

Journal - Research Article

Buss, L. A., Mandani, A., Phillips, E., Scott, N. J. A., Currie, M. J., & Dachs, G. U. (2018). Characterisation of a mouse model of breast cancer with metabolic syndrome. In Vivo, 32(5), 1071-1080. doi: 10.21873/invivo.11348

Journal - Research Article

Journal - Research Other

Buss, L. (2019). Effect of short-term exercise training on tumour blood perfusion and hypoxia in mice. Proceedings of the University of Otago Student Research Symposium: Te Wānaka Rakahau: Ākoka. Retrieved from https://www.otago.ac.nz/graduate-research

Conference Contribution - Published proceedings: Abstract

Buss, L., Currie, M., Ang, A., Hock, B., & Dachs, G. (2018). Exercise reduces hypoxia and increases perfusion in tumours from mice with melanoma. Proceedings of the New Zealand Society for Oncology (NZSO) Conference. Retrieved from http://www.nzsoncology.org.nz/

Conference Contribution - Published proceedings: Abstract

Buss, L., Currie, M., Ang, A., Hock, B., & Dachs, G. (2018, August). Post-tumour-implantation exercise does not alter tumour growth rate in mice with subcutaneous B16-F10 melanoma. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Conference Contribution - Poster Presentation (not in published proceedings)

Buss, L., Currie, M., Ang, A., Hock, B., & Dachs, G. (2018, August). T-cell distribution in melanoma from exercising mice. Verbal presentation at the Queenstown Molecular Biology (QMB) and Australasian Society for Immunology New Zealand Branch (ASI-NZ) Joint Meeting, Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Buss, L. A., & Dachs, G. U. (2017, July). Effects of exercise and hyperlipidaemia on the breast tumour microenvironment. Verbal presentation at the New Zealand Branch of the Australasian Society for Immunology (NZ ASI) Annual Scientific Meeting, Christchurch, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Awarded Doctoral Degree

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