Professor A. Mark Richards

2024

Journal - Research Article

Ou, Y.-H., Colpani, J. T., Cheong, C. S., Loke, W., Thant, A. t., Shih, E. C., … Richards, A. M., … Lee, C.-H. (2024). Mandibular advancement vs CPAP for blood pressure reduction in patients with obstructive sleep apnea. JACC. Advance online publication. doi: 10.1016/j.jacc.2024.03.359

Zhu, Y., Ackers-Johnson, M., Shanmugam, M. K., Pakkiri, L. S., Drum, C. L., Chen, Y., … Richards, A. M., & Foo, R. (2024). Asparagine synthetase marks a distinct dependency threshold for cardiomyocyte dedifferentiation. Circulation. Advance online publication. doi: 10.1161/circulationaha.123.063965

Iyer, N. R., Chan, S.-P., Liew, O. W., Chong, J. P. C., Bryant, J. A., Le, T.-T., … Richards, A. M., … and on behalf of the ATTRaCT investigators. (2024). Global longitudinal strain and plasma biomarkers for prognosis in heart failure complicated by diabetes: A prospective observational study. BMC Cardiovascular Disorders, 24, 141. doi: 10.1186/s12872-024-03810-5

Pickering, J. W., Young, J. M., George, P. M., Watson, A. S., Aldous, S. J., Verryt, T., Troughton, R. W., Pemberton, C. J., Richards, A. M., … Than, M. P. (2024). Derivation and validation of thresholds using synthetic data methods for single-test screening of emergency department patients with possible acute myocardial infarction using a point-of-care troponin assay. Journal of Applied Laboratory Medicine. Advance online publication. doi: 10.1093/jalm/jfae001

Dib, M.-J., Levin, M. G., Zhao, L., Diab, A., Wang, Z., Ebert, C., … Richards, A. M., Doughty, R., … Chirinos, J. A. (2024). Proteomic associations of adverse outcomes in human heart failure. Journal of the American Heart Association, 13, e031154. doi: 10.1161/jaha.123.031154

Sim, H. W., Koh, K. W. L., Poh, S.-C., Chan, S. P., Marchesseau, S., Singh, D., … Richards, A. M., & Chan, M. Y. (2024). Remote intensive management to improve antiplatelet adherence in acute myocardial infarction: A secondary analysis of the randomized controlled IMMACULATE trial. Journal of Thrombosis & Thrombolysis, 57, 408-417. doi: 10.1007/s11239-023-02931-6

Azzo, J. D., Dib, M.-J., Zagkos, L., Zhao, L., Wang, Z., Chang, C.-P., … Richards, A. M., … Chirinos, J. A. (2024). Proteomic associations of NT-proBNP (N-Terminal pro-B-Type Natriuretic Peptide) in heart failure with preserved ejection fraction. Circulation: Heart Failure, 17(2), e011146. doi: 10.1161/circheartfailure.123.011146

van Essen, B. J., Tharshana, G. N., Ouwerkerk, W., Yeo, P. S. D., Sim, D., Jaufeerally, F., … Richards, A. M. (2024). Distinguishing heart failure with reduced ejection fraction from heart failure with preserved ejection fraction: A phenomics approach. European Journal of Heart Failure. Advance online publication. doi: 10.1002/ejhf.3156

Ling, S. S. M., Lilyanna, S., Ng, J. Y. X., Chong, J. P. C., Lin, Q., Yong, X. E., … Richards, A. M., & Liew, O. W. (2024). Multiple circulating forms of neprilysin detected with novel epitope-directed monoclonal antibodies. Cellular & Molecular Life Sciences, 81, 42. doi: 10.1007/s00018-023-05083-1

Appleby, S., Aitken-Buck, H. M., Holdaway, M. S., Byers, M. S., Frampton, C. M., Paton, L. N., Richards, A. M., Lamberts, R. R., & Pemberton, C. J. (2024). Cardiac effects of myoregulin in ischemia-reperfusion. Peptides, 174, 171156. doi: 10.1016/j.peptides.2024.171156

Rademaker, M. T., Scott, N. J. A., Charles, C. J., & Richards, A. M. (2024). Combined inhibition of phosphodiesterases-5 and -9 in experimental heart failure. JACC: Heart Failure, 12(1), 100-113. doi: 10.1016/j.jchf.2023.08.028

Tan, E. S. J., Chan, S. P., Liew, O. W., Chong, J. P. C., Leong, K. T. G., Yeo, P. S. D., … Richards, A. M. (2024). Differential associations of A-/B-type natriuretic peptides with cardiac structure, function, and prognosis in heart failure. JACC: Heart Failure, 12(3), 461-474. doi: 10.1016/j.jchf.2023.09.011

Journal - Research Other

Richards, A. M., Wang, P., & Wong, L. L. (2024). 'Micro'-managing heart failure: Restoring that which was lost in translation [Invited]. European Journal of Heart Failure. Advance online publication. doi: 10.1002/ejhf.3188

Conference Contribution - Published proceedings: Abstract

Salman, O., Zhao, L., Cohen, J. B., Dib, M. J., Azzo, J. D., Gan, S., Richards, A. M., … Chirinos, J. (2024). Proteomic correlates and prognostic significance of kidney injury in heart failure with preserved ejection fraction. Journal of Cardiac Failure, 30(1), (pp. 213-214). doi: 10.1016/j.cardfail.2023.10.235

Azzo, J. D., Dib, M.-J., Zhao, L., Wang, Z., Ebert, C., Salman, O., … Richards, M., … Chirinos, J. (2024). Proteomic associations of N-terminal-pro hormone Bnp in heart failure with preserved ejection fraction in two cohorts. Journal of Cardiac Failure, 30(1), (pp. 120). doi: 10.1016/j.cardfail.2023.10.008

2023

Journal - Research Article

Appleby, S., Frampton, C., Holdaway, M., Chew-Harris, J., Liew, O. W., Chong, J. P. C., Lewis, L., Troughton, R., … Richards, A. M., & Pemberton, C. J. (2023). Circulating erythroferrone has diagnostic utility for acute decompensated heart failure in patients presenting with acute or worsening dyspnea. Frontiers in Cardiovascular Medicine, 10, 1195082. doi: 10.3389/fcvm.2023.1195082

Koo, C.-Y., Zheng, H., Tan, L.-L., Foo, L.-L., Shih, E., Hausenloy, D. J., … Richards, A. M., … Chan, M. Y. (2023). Global Registry of Acute Coronary Events score underestimates post-acute coronary syndrome mortality among cancer patients. Cancers, 15, 5222. doi: 10.3390/cancers15215222

Kalailingam, P., Mohd-Kahliab, K.-H., Ngan, S. C., Iyappan, R., Melekh, E., Lu, T., … Richards, A. M., … Sze, S. K. (2023). Immunotherapy targeting isoDGR-protein damage extends lifespan in a mouse model of protein deamidation. EMBO Molecular Medicine, 15, e18526. doi: 10.15252/emmm.202318526

Wong, L. L., Fadzil, A. B., Chen, Q., Rademaker, M. T., Charles, C. J., Richards, A. M., & Wang, P. (2023). Interrogating the role of miR-125b and its 3’isomiRs in protection against hypoxia. International Journal of Molecular Sciences, 24, 16015. doi: 10.3390/ijms242116015

Ong, C. W., Wee, I. J. Y., Toma, M., Cui, F., Xu, X. Y., Richards, A. M., … Choong, A. M. T. L. (2023). Haemodynamic changes in visceral hybrid repairs of type III and type V thoracoabdominal aortic aneurysms. Scientific Reports, 13, 13760. doi: 10.1038/s41598-023-40323-1

Teramoto, K., Ouwerkerk, W., Tay, W. T., Tromp, J., Teng, T.-H. K., Chandramouli, C., … Richards, A. M., … on behalf of the ASIAN-HF investigators. (2023). Clinical features of heart failure with normal ejection fraction: Insights from the ASIAN-HF Registry. JACC: Asia, 3(5), 739-751. doi: 10.1016/j.jacasi.2023.06.007

Pua, C. J., Loo, G., Kui, M., Moy, W. L., Hii, A.-A., Lee, V., … Richards, A. M., … Chin, C. W. L. (2023). Impact of diabetes on myocardial fibrosis in patients with hypertension: The REMODEL study. Circulation: Cardiovascular Imaging, 16, e015051. doi: 10.1161/circimaging.123.015051

Lawson, C. A., Tay, W. T., Richards, M., Zaccardi, F., Tromp, J., Teng, T.-H. K., … on behalf of the ASIAN-HF investigators. (2023). Patient-reported status and heart failure outcomes in Asia by sex, ethnicity, and socioeconomic status. JACC: Asia, 3(3), 349-362. doi: 10.1016/j.jacasi.2023.03.015

Ji, F., Chai, Y. L., Liu, S., Kan, C. N., Ong, M., Richards, A. M., … Zhou, J. H. (2023). Associations of blood cardiovascular biomarkers with brain free water and its relationship to cognitive decline: A diffusion-MRI study. Neurology, 101(2), e151-e163. doi: 10.1212/wnl.0000000000207401

Doudesis, D., Lee, K. K., Boeddinghaus, J., Bularga, A., Ferry, A. V., Tuck, C., … Pickering, J. W., Than, M. P., … CoDE-ACS Investigators, including Richards, A. M., Pemberton, C., Troughton, R. W., & Aldous, S. J. (2023). Machine learning for diagnosis of myocardial infarction using cardiac troponin concentrations. Nature Medicine, 29, 1201-1210. doi: 10.1038/s41591-023-02325-4

Neumann, J. T., Twerenbold, R., Ojeda, F., Aldous, S. J., Allen, B. R., Apple, F. S., … Pickering, J. W., Pemberton, C. J., … Richards, A. M., … Than, M. P., … Troughton, R. W., … the ARTEMIS study group. (2023). Personalized diagnosis in suspected myocardial infarction. Clinical Research in Cardiology, 112, 1288-1301. doi: 10.1007/s00392-023-02206-3

Michaëlsson, E., Lund, L. H., Hage, C., Shah, S. J., Voors, A. A., Saraste, A., … Richards, A. M., … Lam, C. S. P. (2023). Myeloperoxidase inhibition reverses biomarker profiles associated with clinical outcomes in HFpEF. JACC: Heart Failure, 11(7), 775-787. doi: 10.1016/j.jchf.2023.03.002

Koh, H. W. L., Pilbrow, A. P., Tan, S. H., Zhao, Q., Benke, P. I., Burla, B., … Pickering, J. W., Troughton, R., Pemberton, C., … Richards, A. M., & Chan, M. Y. (2023). An integrated signature of extracellular matrix proteins and a diastolic function imaging parameter predicts post-MI long-term outcomes. Frontiers in Cardiovascular Medicine, 10, 1123682. doi: 10.3389/fcvm.2023.1123682

Lawson, C. A., Tay, W. T., Bernhardt, L., Richards, A. M., Zaccardi, F., Tromp, J., … on behalf of the ASIAN-HF investigators. (2023). Association between diabetes, chronic kidney disease, and outcomes in people with heart failure from Asia. JACC: Asia, 3(4), 611-621. doi: 10.1016/j.jacasi.2023.03.005

Tan, E. S. J., Chan, S.-P., Choi, Y. C., Pemberton, C. J., Troughton, R., Poppe, K., … Richards, A. M. (2023). Regional handling and prognostic performance of circulating insulin-like growth factor binding protein-7 in heart failure. JACC: Heart Failure, 11(6), 662-674. doi: 10.1016/j.jchf.2023.01.016

Templeton, E. M., Pilbrow, A. P., Kleffmann, T., Pickering, J. W., Rademaker, M. T., Scott, N. J. A., Ellmers, L. J., Charles, C. J., Endre, Z. H., Richards, A. M., Cameron, V. A., & Lassé, M. (2023). Comparison of SPEED, S-Trap, and in-solution-based sample preparation methods for mass spectrometry in kidney tissue and plasma. International Journal of Molecular Sciences, 24(7), 6290. doi: 10.3390/ijms24076290

Earle, N. J., Poppe, K. K., Rolleston, A., Pilbrow, A., Aish, S., Bradbury, K., … Troughton, R. W., … Richards, A. M., Cameron, V. A., … Doughty, R. N. (2023). Prognostic modelling of clinical outcomes after first-time acute coronary syndrome in New Zealand. Heart, 109(14), 1088-1097. doi: 10.1136/heartjnl-2022-322010

Teng, T.-H. K., Tay, W. T., Ouwerkerk, W., Tromp, J., Richards, A. M., Gamble, G., … Troughton, R., … Doughty, R. N. (2023). Titration of medications and outcomes in multi-ethnic heart failure cohorts (with reduced ejection fraction) from Singapore and New Zealand. ESC Heart Failure, 10(2), 1280-1293. doi: 10.1002/ehf2.14275

Vinaiphat, A., Pazhanchamy, K., JebaMercy, G., Ngan, S. C., Leow, M. K.-S., Ho, H. H., … Richards, A. M., … Sze, S. K. (2023). Endothelial damage arising from high salt hypertension Is elucidated by vascular bed systematic profiling. Arteriosclerosis, Thrombosis, & Vascular Biology, 43(3). doi: 10.1161/atvbaha.122.318439

Chin, Y., Lim, J., Kong, G., Ng, C. H., Goh, R., Muthiah, M., … Richards, A. M., … Chew, N. W. S. (2023). Hepatic steatosis and advanced hepatic fibrosis are independent predictors of long-term mortality in acute myocardial infarction. Diabetes, Obesity & Metabolism, 25, 1032-1044. doi: 10.1111/dom.14950

Sazzad, F., Kuzemczak, M., Chen, Z. J., Tan, J. F., Ong, Z. X., Richards, A. M., & Kofidis, T. (2023). Transcatheter targeted myocardial restoration using hydrogel-based cell-free compound: Toward an adoptable clinical protocol. JTCVS Open, 13, 184-196. doi: 10.1016/j.xjon.2022.12.008

Scott, N. J. A., Prickett, T. C. R., Charles, C. J., Frampton, C. M., Richards, A. M., & Rademaker, M. T. (2023). Augmentation of natriuretic peptide bioactivity via combined inhibition of neprilysin and phosphodiesterase-9 in heart failure. JACC: Heart Failure, 11(2), 227-239. doi: 10.1016/j.jchf.2022.11.006

Lim, X. C., Huang, C., Yatim, S. M. J. M., Chong, S. Y., Tan, S. H., Yang, X., … Richards, A. M., Charles, C. J., … Wang, J.-W. (2023). Temporal changes in extracellular vesicle hemostatic protein composition predict favourable left ventricular remodeling after acute myocardial infarction. International Journal of Molecular Sciences, 24, 327. doi: 10.3390/ijms24010327

Teramoto, K., Tay, W. T., Tromp, J., Teng, T.-H. K., Chandramouli, C., Ouwerkerk, W., … Richards, A. M., & Lam, C. S. P. (2023). Patient-reported versus physician-assessed health status in heart failure with reduced and preserved ejection fraction from ASIAN-HF Registry. Circulation: Cardiovascular Quality & Outcomes, 16(1), e009134. doi: 10.1161/circoutcomes.122.009134

Tan, E. S. J., Jin, X., Oon, Y. Y., Chan, S. P., Gong, L., Lunaria, J. B., … Richards, A. M. (2023). Prognostic value of left atrial strain in aortic stenosis: A competing risk analysis. Journal of the American Society of Echocardiography, 36(1), 29-37. doi: 10.1016/j.echo.2022.10.011

Journal - Research Other

Devlin, G., Tukuitonga, C., Grey, C., Richards, M., Rolleston, A., Doughty, R., Legget, M., & Mann, J. (2023). Call to action: The urgent need for a heart health plan in New Zealand. New Zealand Medical Journal/Te ara tika o te hauora hapori, 136(1585), 103-108. Retrieved from https://journal.nzma.org.nz/

Lee, V., Zheng, Q., Toh, D.-F., Pua, C. J., Bryant, J. A., Lee, C.-H., … Richards, A. M., … Chin, C. W. L. (2023). Sacubitril/valsartan versus valsartan in regressing myocardial fibrosis in hypertension: A prospective, randomized, open-label, blinded endpoint clinical trial protocol. Frontiers in Cardiovascular Medicine, 10, 1248468. doi: 10.3389/fcvm.2023.1248468

Richards, A. M. (2023). Plasma markers to risk stratify for heart failure in atrial fibrillation [Invited]. European Journal of Heart Failure, 25, 842-844. doi: 10.1002/ejhf.2885

Conference Contribution - Published proceedings: Abstract

Phung, K., Earle, N., Poppe, K., Rolleston, A., Devlin, G., Richards, M., Troughton, R., & Doughty, R. (2023). Growth differentiation factor-15 in patients recovering from acute coronary syndromes. Heart, Lung & Circulation, 32(Suppl. 2), P18. doi: 10.1016/j.hlc.2023.04.239

Montecillo, J., Pirker, T., Richards, M., Pemberton, C., & Chew-Harris, J. (2023). Protein glycosylation influences soluble urokinase Plasminogen Activator Receptor (suPAR) measurements. Heart, Lung & Circulation, 32(Suppl. 2), P16. doi: 10.1016/j.hlc.2023.04.237

Riddell, C., Poppe, K., Choi, Y. C., Earle, N., Edwards, N. C., Pilmore, H., … Troughton, R., … Richards, A. M., & Doughty, R. N. (2023). Changes in estimated glomerular filtration rate and prognostication using 2021 chronic kidney disease epidemiology collaboration estimated glomerular filtration rate equations incorporating cystatin C. Heart, Lung & Circulation, 32(Suppl. 2), O03. doi: 10.1016/j.hlc.2023.04.209

Pirker, T., Keys, T., Pham, T., Montecillo, J., Byers, M., Pemberton, C., Richards, M., & Chew-Harris, J. (2023). Soluble urokinase Plasminogen Activator Receptor (suPAR) promotes cardioprotective intracellular signalling in myocardial ischaemia. Heart, Lung & Circulation, 32(Suppl. 2), O02. doi: 10.1016/j.hlc.2023.04.208

Poppe, K., Doughty, R., Choi, Y., Devlin, G., Lund, M., Troughton, R., Richards, M., … Pilbrow, A. (2023). Assessing the accuracy of algorithms that predict ejection fraction for research in a cohort of patients with heart failure. Heart, Lung & Circulation, 32(Suppl. 2), P31. doi: 10.1016/j.hlc.2023.04.252

2022

Journal - Research Article

Eggers, K. M., Hammarsten, O., Aldous, S. J., Cullen, L., Greenslade, J., Lindahl, B., … Pemberton, C. J., Pickering, J. W., Richards, A. M., Troughton, R. W., & Than, M. P. (2022). Diagnostic and prognostic performance of the ratio between high-sensitivity cardiac troponin I and troponin T in patients with chest pain. PLoS ONE, 17(11), e0276645. doi: 10.1371/journal.pone.0276645

Chirinos, J. A., Zhao, L., Reese-Petersen, A. L., Cohen, J. B., Genovese, F., Richards, A. M., … Cappola, T. P. (2022). Endotrophin, a collagen VI formation-derived peptide, in heart failure. NEJM Evidence, 1(10). doi: 10.1056/evidoa2200091

Robert, C., Ling, L.-H., Tan, E. S. J., Gyanwali, B., Venketasubramanian, N., Lim, S. L., … Richards, A. M., … Hilal, S. (2022). Effects of carotid artery stiffness on cerebral small-vessel disease and cognition. Journal of the American Heart Association, 11, e027295. doi: 10.1161/jaha.122.027295

Weissmann, J., Charles, C. J., Richards, A. M., Yap, C. H., & Marom, G. (2022). Material property alterations for phenotypes of heart failure with preserved ejection fraction: A numerical study of subject-specific porcine models. Frontiers in Bioengineering & Biotechnology, 10, 1032034. doi: 10.3389/fbioe.2022.1032034

Ward, Z., Schmeier, S., Pearson, J., Cameron, V. A., Frampton, C. M., Troughton, R. W., … Richards, A. M., & Pilbrow, A. P. (2022). Identifying candidate circulating RNA markers for coronary artery disease by deep RNA-sequencing in human plasma. Cell, 11, 3191. doi: 10.3390/cells11203191

Koo, C. Y., Zheng, H., Tan, L. L., Foo, L.-L., Hausenloy, D. J., Chng, W.-J., … Richards, A. M., … Chan, M. Y. (2022). Prior cancer is associated with lower Atherosclerotic Cardiovascular Disease risk at first acute myocardial infarction. Biomedicines, 10, 2681. doi: 10.3390/biomedicines10112681

Zheng, Y., Chan, W. X., Charles, C. J., Richards, A. M., Lee, L. C., Leo, H. L., & Yap, C. H. (2022). Morphological, functional, and biomechanical progression of LV remodelling in a porcine model of HFpEF. Journal of Biomechanics, 144, 111348. doi: 10.1016/j.jbiomech.2022.111348

Manandhar, S., Scott-Thomas, A., Harrington, M., Sinha, P., Pilbrow, A., Richards, A. M., Cameron, V., Bhatia, M., & Chambers, S. T. (2022). Hydrogen sulfide and substance P levels in patients with Escherichia coli and Klebsiella pneumoniae bacteraemia. International Journal of Molecular Sciences, 23, 8639. doi: 10.3390/ijms23158639

Lewis, L. K., Raudsepp, S. D., Whitlow, J. C., Appleby, S., Pemberton, C. J., Yandle, T. G., & Richards, A. M. (2022). Assays specific for BNP1-32 and NT-proBNP exhibit a similar performance to two widely used assays in the diagnosis of heart failure. Clinical Chemistry, 68(10), 1292-1301. doi: 10.1093/clinchem/hvac126

Liew, O. W., Fanusi, F., Ng, J. Y. X., Ahidjo, B. A., Ling, S. S. M., Lilyanna, S., … Richards, A. M. (2022). Immunoassay-compatible inactivation of SARS-CoV-2 in plasma samples for enhanced handling safety. ACS Omega, 7(29), 25510-25520. doi: 10.1021/acsomega.2c02585

Wu, Z., Pilbrow, A. P., Liew, O. W., Chong, J. P. C., Sluyter, J., Lewis, L. K., Lasse, M., Frampton, C. M., … Cameron, V. A., … Richards, A. M. (2022). Circulating cardiac biomarkers improve risk stratification for incident cardiovascular disease in community dwelling populations. EBioMedicine, 82, 104170. doi: 10.1016/j.ebiom.2022.104170

Schillemans, T., Tragante, V., Maitusong, B., Gigante, B., Cresci, S., Laguzzi, F., … Richards, M., Pilbrow, A., Cameron, V., … Leander, K. (2022). Associations of polymorphisms in the peroxisome proliferator-activated receptor gamma coactivator-1 alpha gene with subsequent coronary heart disease: An individual-level meta-analysis. Frontiers in Physiology, 13, 909870. doi: 10.3389/fphys.2022.909870

Sia, C.-H., Tan, S.-H., Chan, S.-P., Marchesseau, S., Sim, H.-W., Carvalho, L., … Richards, A. M., … Chan, M. Y. (2022). Enhanced thrombin generation is associated with worse left ventricular scarring after ST-segment elevation myocardial infarction: A cohort study. Pharmaceuticals, 15, 718. doi: 10.3390/ph15060718

Zheng, Y., Chan, W. X., Charles, C. J., Richards, A. M., Sampath, S., Ali, A. A. B., … Yap, C. H. (2022). Effects of hypertrophic and dilated cardiac geometric remodeling on ejection fraction. Frontiers in Physiology, 13, 898775. doi: 10.3389/fphys.2022.898775

Lee, K. K., Doudesis, D., Anwar, M., Astengo, A., Chenevier-Gobeaux, C., Claessens, Y.-E., … Pemberton, C., … Richards, A. M., … on behalf of the CoDE-HF investigators. (2022). Development and validation of a decision support tool for the diagnosis of acute heart failure: Systematic review, meta-analysis, and modelling study. BMJ, 377, e068424. doi: 10.1136/bmj-2021-068424

Vergaro, G., Gentile, F., Aimo, A., Januzzi, Jr, J. L., Richards, A. M., Lam, C. S. P., … Troughton, R., … Emdin, M. (2022). Circulating levels and prognostic cut-offs of sST2, hs-cTnT, and NT-proBNP in women vs. men with chronic heart failure. ESC Heart Failure, 9, 2084-2095. doi: 10.1002/ehf2.13883

Jin, X., Hung, C.-L., Tay, W. T., Soon, D., Sim, D., Sung, K.-T., … Richards, A. M., … Lam, C. S. P. (2022). Epicardial adipose tissue related to left atrial and ventricular function in heart failure with preserved versus reduced and mildly reduced ejection fraction. European Journal of Heart Failure, 24, 1346-1356. doi: 10.1002/ejhf.2513

Tan, E. S. J., Oon, Y. Y., Chan, S. P., Liew, O. W., Chong, J. P. C., Tay, E., … Richards, A. M., & Ling, L. H. (2022). Novel predictive role for mid-regional proadrenomedullin in moderate to severe aortic stenosis. Heart, 108, 1319-1327. doi: 10.1136/heartjnl-2021-320707

Liew, O. W., Prickett, T. C. R., Revuelta-López, E., Ling, S. S. M., Cserkóová, A., Lupón, J., … Richards, A. M. (2022). Finding a reliable assay for soluble neprilysin. Clinical Biochemistry, 104, 51-58. doi: 10.1016/j.clinbiochem.2022.03.004

Wu, Z., Sluyter, J., Liew, O. W., Chong, J. P. C., Waayer, D., Camargo, Jr, C. A., Richards, A. M., & Scragg, R. (2022). Effect of monthly vitamin D supplementation on cardiac biomarkers: A post-hoc analysis of a randomized controlled trial. Journal of Steroid Biochemistry & Molecular Biology, 220, 106093. doi: 10.1016/j.jsbmb.2022.106093

Tan, S. H., Koh, H. W. L., Chua, J. Y., Burla, B., Ong, C. C., Teo, L. S. L., … Richards, A. M., … Chan, M. Y. (2022). Variability of the plasma lipidome and subclinical coronary atherosclerosis. Arteriosclerosis, Thrombosis, & Vascular Biology, 42, 100-112. doi: 10.1161/ATVBAHA.121.316847

Templeton, E. M., Lassé, M., Kleffmann, T., Ellmers, L. J., Palmer, S. C., Davidson, T., Scott, N. J. A., Pickering, J. W., Charles, C. J., Endre, Z. H., Cameron, V. A., Richards, A. M., Rademaker, M. T., & Pilbrow, A. P. (2022). Identifying candidate protein markers of acute kidney injury in acute decompensated heart failure. International Journal of Molecular Sciences, 23, 1009. doi: 10.3390/ijms23021009

Fitzsimons, S., Poppe, K. K., Choi, Y., Devlin, G., Lund, M., Lam, C. S. P., Troughton, R., Richards, A. M., & Doughty, R. N. (2022). Relationship between soluble transferrin receptor and clinical outcomes in patients with heart failure according to ejection fraction phenotype: The New Zealand PEOPLE study. Journal of Cardiac Failure, 28(8), 1255-1263. doi: 10.1016/j.cardfail.2021.12.018

Zhou, Y., Ng, D. Y. E., Richards, A. M., & Wang, P. (2022). Loss of full length pumilio 1 abrogates miRNA-221-induced gene p27 silencing–mediated cell proliferation in the heart. Molecular Therapy: Nucleic Acids, 27, 456-470. doi: 10.1016/j.omtn.2021.12.012

Tromp, J., Seekings, P. J., Hung, C.-L., Iversen, M. B., Frost, M. J., Ouwerkerk, W., … Richards, A. M., … Ezekowitz, J. A. (2022). Automated interpretation of systolic and diastolic function on the echocardiogram: A multicohort study. Lancet Digital Health, 4, e46-e54. doi: 10.1016/s2589-7500(21)00235-1

Vergaro, G., Aimo, A., Januzzi, Jr, J. L., Richards, A. M., Lam, C. S. P., Latini, R., … Troughton, R., … Passino, C. (2022). Cardiac biomarkers retain prognostic significance in patients with heart failure and chronic obstructive pulmonary disease. Journal of Cardiovascular Medicine, 23(1), 28-36. doi: 10.2459/jcm.0000000000001281

Weissmann, J., Charles, C. J., Richards, A. M., Yap, C. H., & Marom, G. (2022). Cardiac mesh morphing method for finite element modeling of heart failure with preserved ejection fraction. Journal of the Mechanical Behavior of Biomedical Materials, 126, 104937. doi: 10.1016/j.jmbbm.2021.104937

Journal - Research Other

Bayes-Genis, A., Aimo, A., Jhund, P., Richards, A. M., de Boer, R. A., Arfsten, H., … Januzzi, J. L. (2022). Biomarkers in heart failure clinical trials: A review from the Biomarkers Working Group of the Heart Failure Association of the European Society of Cardiology. European Journal of Heart Failure, 24, 1767-1777. doi: 10.1002/ejhf.2675

Núñez, J., de la Espriella, R., Rossignol, P., Voors, A. A., Mullens, W., Metra, M., … Richards, A. M., … Bayes-Genis, A. (2022). Congestion in heart failure: A circulating biomarker-based perspective. A review from the Biomarkers Working Group of the Heart Failure Association, European Society of Cardiology. European Journal of Heart Failure, 24, 1751-1766. doi: 10.1002/ejhf.2664

Richards, A. M. (2022). Optimizing the diagnostic utility of NT-proBNP for acute heart failure in obesity and beyond. European Journal of Heart Failure, 24, 1555-1558. doi: 10.1002/ejhf.2653

Aimo, A., Vergaro, G., González, A., Barison, A., Lupón, J., Delgado, V., Richards, A. M., … Bayes-Genis, A. (2022). Cardiac remodelling Part 2: Clinical, imaging and laboratory findings. A review from the Study Group on Biomarkers of the Heart Failure Association of the ESC. European Journal of Heart Failure, 24, 944-958. doi: 10.1002/ejhf.2522

González, A., Richards, A. M., de Boer, R. A., Thum, T., Arfsten, H., Hülsmann, M., … Bayes-Genis, A. (2022). Cardiac remodelling Part 1: From cells and tissues to circulating biomarkers. A review from the Study Group on Biomarkers of the Heart Failure Association of the ESC. European Journal of Heart Failure, 24, 927-943. doi: 10.1002/ejhf.2493

Conference Contribution - Published proceedings: Abstract

Tromp, J., Seekings, P., Hung, C.-L., Iversen, M., Frost, M., Ouwerkerk, W., … Richards, M., … Ezekowitz, J. (2022). Automated interpretation of systolic and diastolic function on the echocardiogram. Journal of Cardiac Failure, 28(5, Suppl.), (pp. 104-105). doi: 10.1016/j.cardfail.2022.03.266

Chew-Harris, J., Kuan, W. S., Ibrahim, I., Chan, S. P., Li, Z., Liew, O. W., Appleby, S., Frampton, C., Troughton, R., … Richards, A. M., & Pemberton, C. J. (2022). Comparative performances of soluble urokinase plasminogen activator receptor and Mid-regional proADM to predict composite death and new heart failure rehospitalisation in acutely breathless patients. European Heart Journal, 43(Suppl. 2), (pp. 1087). doi: 10.1093/eurheartj/ehac544.1087

Keys, T., Chew-Harris, J., Pemberton, C., Adamson, P., Troughton, R., Doughty, R., & Richards, A. M. (2022). Soluble urokinase plasminogen activator receptor predicts mortality and adverse cardiovascular outcomes following acute coronary syndrome. Heart, Lung & Circulation, 31(Suppl. 2), (pp. S28-S29). doi: 10.1016/j.hlc.2022.05.020

Templeton, E., Lassé, M., Cameron, V., Pickering, J., Kleffmann, T., Hertzberg, D., Frampton, C., Ellmers, L., Palmer, S., … Scott, N., Charles, C., … Richards, M., … Troughton, R., Rademaker, M., & Pilbrow, A. (2022). Harnessing the power of 'Omics': Discovering novel microRNA and protein biomarkers of acute kidney injury in acute heart failure. Heart, Lung & Circulation, 31(Suppl. 2), (pp. S23-S24). doi: 10.1016/j.hlc.2022.05.009

Lewis, L., Raudsepp, S., Whitlow, J., Appleby, S., Pemberton, C., & Richards, A. M. (2022). Do more specific assays for B-type natriuretic peptides better predict heart failure in breathless patients than the currently used assays? European Heart Journal, 43(Suppl. 1), (pp. i76). doi: 10.1093/eurheartj/ehab849.060

Conference Contribution - Verbal presentation and other Conference outputs

Tragante, V., Poppe, K., Cameron, V. A., Jones, G. T., Frampton, C. M., Troughton, R. W., Richards, A. M., … Pilbrow, A. P. (2022, August). Predicting progression from coronary artery disease to heart failure. Verbal presentation at the Metabolic & Cardiovascular Disease Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.

2021

Journal - Research Article

Tromp, J., Ouwerkerk, W., van Veldhuisen, D. J., Hillege, H. L., Richards, A. M., van der Meer, P., … Voors, A. A. (2021). A systematic review and network-meta-analysis of pharmacological treatment of heart failure with reduced ejection fraction. JACC: Heart Failure, 10(2), 73-84. doi: 10.1016/j.jchf.2021.09.004

Aung, T., Qin, Y., Tay, W. T., Bamadhaj, N. S. B. S., Chandramouli, C., Ouwerkerk, W., … Richards, A. M., … Lam, C. S. P. (2021). Prevalence and prognostic significance of frailty in Asian patients with heart failure: Insights from ASIAN-HF. JACC: Asia, 1(3), 303-313. doi: 10.1016/j.jacasi.2021.09.006

Koh, C. Y., Shih, N., Yip, C. Y. C., Li, A. W. L., Chen, W., Amran, F. S., … Richards, A. M., … Chan, M. Y. (2021). Efficacy and safety of next-generation tick transcriptome-derived direct thrombin inhibitors. Nature Communications, 12, 6912. doi: 10.1038/s41467-021-27275-8

Koo, C. Y., Zheng, H., Tan, L. L., Foo, L. L., Seet, R., Chong, J.-H., … Richards, A. M., … Chan, M. Y. (2021). Lipid profiles and outcomes of patients with prior cancer and subsequent myocardial infarction or stroke. Scientific Reports, 11, 21167. doi: 10.1038/s41598-021-00666-z

Tay, W. T., Teng, T.-H. K., Simon, O., Ouwerkerk, W., Tromp, J., Doughty, R. N., Richards, A. M., … on behalf of the ASIAN-HF investigators. (2021). Readmissions, death and its associated predictors in heart failure with preserved versus reduced ejection fraction. Journal of the American Heart Association, 10(e021414). doi: 10.1161/jaha.121.021414

Fitzsimons, S., Yeo, T. J., Ling, L. H., Sim, D., Leong, K. T. G., Yeo, P. S. D., … Troughton, R., … Richards, A. M., & Doughty, R. N. (2021). Impact of change in iron status over time on clinical outcomes in heart failure according to ejection fraction phenotype. ESC Heart Failure, 8, 4572-4583. doi: 10.1002/ehf2.13617

Rademaker, M. T., Pilbrow, A. P., Ellmers, L. J., Palmer, S. C., Davidson, T., Mbikou, P., Scott, N. J. A., Permina, E., Charles, C. J., Endre, Z. H., & Richards, A. M. (2021). Acute decompensated heart failure and the kidney: Physiological, histological and transcriptomic responses to development and recovery. Journal of the American Heart Association, 10, e021312. doi: 10.1161/jaha.121.021312

Palmer, B. R., Paterson, M. A., Frampton, C. M., Pilbrow, A. P., Skelton, L., Pemberton, C. J., … Troughton, R. W., Richards, A. M., & Cameron, V. A. (2021). Vascular endothelial growth factor-A promoter polymorphisms, circulating VEGF-A and survival in acute coronary syndromes. PLoS ONE, 16(7), e0254206. doi: 10.1371/journal.pone.0254206

Vergaro, G., Gentile, F., Meems, L. M. G., Aimo, A., Januzzi, Jr, J. L., Richards, A. M., … Emdin, M. (2021). NT-proBNP for risk prediction in heart failure: Identification of optimal cutoffs across body mass index categories. JACC: Heart Failure, 9(9), 653-663. doi: 10.1016/j.jchf.2021.05.014

Lim, S. L., Liu, X., Gao, Q., Nyunt, S. Z., Gong, L., Lunaria, J. B., … Richards, A. M., … Ng, T. P. (2021). Subclinical vasculopathy and skeletal muscle metrics in the Singapore longitudinal ageing study. Aging, 13(11), 14768-14784. doi: 10.18632/aging.203142

Teng, T.-H. K., Tay, W. T., Richards, A. M., Chew, T. S. M., Anand, I., Ouwerkerk, W., … on behalf of the ASIAN-HF investigators. (2021). Socioeconomic status and outcomes in heart failure with reduced ejection fraction from Asia. Circulation: Cardiovascular Quality & Outcomes, 14(4), e006962. doi: 10.1161/CIRCOUTCOMES.120.006962

Fadil, H., Totman, J. J., Hausenloy, D. J., Ho, H.-H., Joseph, P., Low, A. F.-H., Richards, A. M., … Marchesseau, S. (2021). A deep learning pipeline for automatic analysis of multi-scan cardiovascular magnetic resonance. Journal of Cardiovascular Magnetic Resonance, 23, 47. doi: 10.1186/s12968-020-00695-z

Liew, O. W., Ling, S. S. M., Lilyanna, S., Zhou, Y., Wang, P., Chong, J. P. C., … Richards, A. M. (2021). Epitope-directed monoclonal antibody production using a mixed antigen cocktail facilitates antibody characterization and validation. Communications Biology, 4, 441. doi: 10.1038/s42003-021-01965-x

Park, J. E., JebaMercy, G., Pazhanchamy, K., Guo, X., Ngan, S. C., Liou, K. C. K., … Richards, A. M., … Sze, S. K. (2021). Aging-induced isoDGR-modified fibronectin activates monocytic and endothelial cells to promote atherosclerosis. Atherosclerosis, 324, 58-68. doi: 10.1016/j.atherosclerosis.2021.03.020

Lin, Z., Lim, S. H., Yap, Q. V., Tan, C. H. C., Chan, Y. H., Wong, H. C., … Richards, A. M., & Chua, T. S. J. (2021). Comparing conventional and high sensitivity troponin T measurements in identifying adverse cardiac events in patients admitted to an Asian emergency department chest pain observation unit. IJC Heart & Vasculature, 34, 100758. doi: 10.1016/j.ijcha.2021.100758

Schunk, S. J., Kleber, M. E., März, W., Pang, S., Zewinger, S., Triem, S., … Pilbrow, A. P., Richards, A. M., Cameron, V. A., … BIOS consortium. (2021). Genetically determined NLRP3 inflammasome activation associates with systemic inflammation and cardiovascular mortality. European Heart Journal, 42, 1742-1756. doi: 10.1093/eurheartj/ehab107

Lassé, M., Pilbrow, A. P., Kleffmann, T., Andersson Överström, E., von Zychlinski, A., Frampton, C. M. A., … Troughton, R. W., Lewis, L. K., Prickett, T. C. R., Pemberton, C. J., Richards, A. M., & Cameron, V. A. (2021). Fibrinogen and hemoglobin predict near future cardiovascular events in asymptomatic individuals. Scientific Reports, 11(1), 4605. doi: 10.1038/s41598-021-84046-7

Singh, S., de Ronde, M. W. J., Creemers, E. E., Van der Made, I., Meijering, R., Chan, M. Y., … Richards, A. M., Troughton, R. W., … Pinto-Sietsma, S. J. (2021). Low miR-19b-1-5p Expression is related to aspirin resistance and major adverse cardio- cerebrovascular events in patients with acute coronary syndrome. Journal of the American Heart Association, 10(2), e017120. doi: 10.1161/jaha.120.017120

Poh, K. K., Shabbir, A., Ngiam, J. N., Lee, P. S. S., So, J., Frampton, C. M., Pemberton, C. J., & Richards, A. M. (2021). Plasma clearance of B-type natriuretic peptide (BNP) before and after bariatric durgery for morbid obesity. Clinical Chemistry, 67(4), 662-671. doi: 10.1093/clinchem/hvaa308

Tan, E. S. J., Chan, S.-P., Liew, O.-W., Chong, J. P. C., Leong, G. K. T., Yeo, D. P. S., … Richards, A. M. (2021). Atrial fibrillation and the prognostic performance of biomarkers in heart failure. Clinical Chemistry, 67(1), 216-226. doi: 10.1093/clinchem/hvaa287

Rademaker, M. T., Scott, N. J. A., Koh, C. Y., Manjunatha Kini, R., & Richards, A. M. (2021). Natriuretic peptide analogues with distinct vasodilatory or renal activity: Integrated effects in health and experimental heart failure. Cardiovascular Research, 117, 508-519. doi: 10.1093/cvr/cvaa052

Templeton, E. M., Cameron, V. A., Pickering, J. W., Richards, A. M., & Pilbrow, A. P. (2021). Emerging microRNA biomarkers for acute kidney injury in acute decompensated heart failure. Heart Failure Reviews, 26, 1203-1217. doi: 10.1007/s10741-020-09928-w

Journal - Research Other

Moura, B., Aimo, A., Al-Mohammad, A., Flammer, A., Barberis, V., Bayes-Genis, A., … Richards, A. M. (2021). Integration of imaging and circulating biomarkers in heart failure: A consensus document by the Biomarkers and Imaging Study Groups of the Heart Failure Association of the European Society of Cardiology. European Journal of Heart Failure, 23, 1577-1596. doi: 10.1002/ejhf.2339

Richards, A. M. (2021). Proteomic probing for markers and mechanisms in heart failure [Invited]. Cardiovascular Research, 117, 2137-2139. doi: 10.1093/cvr/cvab258

Richards, A. M., & Pemberton, C. J. (2021). Progress in proteomic probing for pathogenic pathways in heart failure with preserved ejection fraction. European Journal of Heart Failure, 23, 1645-1647. doi: 10.1002/ejhf.2332

Wang, P., Zhou, Y., & Richards, A. M. (2021). Effective tools for RNA-derived therapeutics: siRNA interference or miRNA mimicry. Theranostics, 11(18), 8771-8796. doi: 10.7150/thno.62642

Legget, M. E., Cameron, V. A., Poppe, K. K., Aish, S., Earle, N., Choi, Y., … Troughton, R., Richards, A. M., … Doughty, R. N. (2021). The Multi-Ethnic New Zealand Study of Acute Coronary Syndromes (MENZACS): Design and methodology. Cardiogenetics, 11(2), 84-97. doi: 10.3390/cardiogenetics11020010

Bayes-Genis, A., Januzzi, J. L., Richards, A. M., Aftsten, H., de Boer, R. A., Emdin, M., … Seferovic, P. (2021). The "Peptide for life" initiative: A call for action to provide equal access to the use of natriuretic peptides in the diagnosis of acute heart failure across Europe. European Journal of Heart Failure, 23, 1432-1436. doi: 10.1002/ejhf.2293

Richards, A. M., & Pemberton, C. J. (2021). Urinary peptides in heart failure: The need for care with pees and cues. European Journal of Heart Failure, 23, 1888-1890. doi: 10.1002/ejhf.2269

Tromp, J., Bryant, J. A., Jin, X., van Woerden, G., Asali, S., Yiying, H., … Richards, A. M., … Lam, C. S. P. (2021). Epicardial fat in heart failure with reduced versus preserved ejection fraction [Research letters]. European Journal of Heart Failure, 23(5), 835-838. doi: 10.1002/ejhf.2156

Richards, A. M. (2021). Cardiac myosin-binding protein C as a candidate biomarker in heart failure: Rational but not revolutionary [Editorial comment]. European Journal of Heart Failure, 23, 726-728. doi: 10.1002/ejhf.2126

Chan, M. Y., Koh, K. W. L., Poh, S.-C., Marchesseau, S., Singh, D., Han, Y., … for the IMMACULATE Investigators, including Richards, A. M. (2021). Remote postdischarge treatment of patients with acute myocardial infarction by allied health care practitioners vs standard care: The IMMACULATE randomized clinical trial. JAMA Cardiology, 6(7), 830-835. doi: 10.1001/jamacardio.2020.6721

Conference Contribution - Published proceedings: Abstract

Holdaway, M., Lewis, L., Chew-Harris, J., Richards, M., Pemberton, C., & Appleby, S. (2021). Erythroferrone can diagnose acute decompensated heart failure in patients presenting with breathlessness. Heart, Lung & Circulation, 30(Suppl. 2), (pp. S76). doi: 10.1016/j.hlc.2021.05.044

Earle, N., Poppe, K., Cameron, V., Aish, S., Choi, Y., Wall, C., … Troughton, R., … Richards, M., … Doughty, R. (2021). Outcomes among patients with first-time acute coronary syndromes in New Zealand: The Multi-Ethnic New Zealand Study of Acute Coronary Syndromes (MENZACS). Heart, Lung & Circulation, 30(Suppl. 2), (pp. S63). doi: 10.1016/j.hlc.2021.05.014

Templeton, E., Lassé, M., Kleffmann, T., Ellmers, L. J., Palmer, S. C., Davidson, T., Scott, N. J., Pickering, J. W., Charles, C. J., Endre, Z. H., Cameron, V. A., & Richards, A. M. (2021). Identifying candidate protein markers of acute kidney injury in acute decompensated heart failure. Heart, Lung & Circulation, 30(Suppl. 2), (pp. S66). doi: 10.1016/j.hlc.2021.05.020

Chew-Harris, J., Appleby, S., Adamson, P., Troughton, R., Richards, A. M., & Pemberton, C. (2021). Soluble urokinase plasminogen activator receptor (suPAR) predicts 2-year cardiovascular events in patients after acute chest pain. Heart, Lung & Circulation, 30(Suppl. 2), (pp. S85-S86). doi: 10.1016/j.hlc.2021.05.070

Chew-Harris, J., Appleby, S., Adamson, P., Troughton, R., Richards, A. M., & Pemberton, C. (2021). Prognostic performance of soluble urokinase plasminogen activator receptor (suPAR) in predicting mortality in Asian and Western patients with acute breathlessness. Heart, Lung & Circulation, 30(Suppl. 2), (pp. S86). doi: 10.1016/j.hlc.2021.05.070

Chew-Harris, J., Appleby, S., Adamson, P., Troughton, R., Richards, A. M., & Pemberton, C. (2021). Soluble urokinase plasminogen activator receptor (suPAR) predicts mortality in patients with acute chest pain. Heart, Lung & Circulation, 30(Suppl. 2), (pp. S86). doi: 10.1016/j.hlc.2021.05.069

Castiglione, V., Chiriaco', M., Aimo, A., Januzzi, J., Richards, A. M., Lam, C. S. P., … Vergaro, G. (2021). Prognostic value of sST2 in heart failure patients with diabetes. European Heart Journal, 42(Suppl. 1), (pp. 869). doi: 10.1093/eurheartj/ehab724.0869

Aimo, A., Vergaro, G., Januzzi, J., Richards, A. M., Lam, C. S. P., Latini, R., … Troughton, R., … Emdin, M. (2021). Additive prognostic value of cardiac biomarkers in patients with chronic obstructive pulmonary disease and heart failure. European Heart Journal, 42(Suppl. 1), (pp. 987). doi: 10.1093/eurheartj/ehab724.0987

2020

Journal - Research Article

Charles, C. J., Li, R. R., Yeung, T., Mazlan, S. M. I., Lai, R. C., de Kleijn, D. P. V., … Richards, A. M. (2020). Systemic mesenchymal stem cell-derived exosomes reduce myocardial infarct size: Characterization with MRI in a porcine model. Frontiers in Cardiovascular Medicine, 7, 601990. doi: 10.3389/fcvm.2020.601990

Lim, S. L., Gandhi, M., Woo, K. L., Chua, H. R., Lim, Y. C., Sim, D. K. L., … Richards, A. M., & Lam, C. S. P. (2020). Nitrates in combination with hydralazine in cardiorenal syndrome: A randomized controlled proof-of-concept study. ESC Heart Failure, 7, 4267-4276. doi: 10.1002/ehf2.13076

Zhou, Y., Ng, D. Y. E., Richards, A. M., & Wang, P. (2020). MicroRNA-221 inhibits latent TGF-β1 activation through targeting thrombospondin-1 to attenuate kidney failure-induced cardiac fibrosis. Molecular Therapy: Nucleic Acids, 22, 803-814. doi: 10.1016/j.omtn.2020.09.041

Chan, M. Y., Efthymios, M., Tan, S. H., Pickering, J. W., Troughton, R., Pemberton, C., … Pilbrow, A., & Richards, A. M. (2020). Prioritizing candidates of post-myocardial infarction heart failure using plasma proteomics and single-cell transcriptomics. Circulation, 142, 1408-1421. doi: 10.1161/circulationaha.119.045158

Huang, W., Teng, T.-H. K., Tay, W. T., Richards, A. M., Kadam, U., Lawson, C. A., … Lam, C. S. P. (2020). Patient-reported outcomes in heart failure with preserved vs. reduced ejection fraction: Focus on physical independence. ESC Heart Failure, 7, 2051-2062. doi: 10.1002/ehf2.12950

Mahmoodi, B. K., Tragante, V., Kleber, M. E., Holmes, M. V., Schmidt, A. F., McCubrey, R. O., … Pilbrow, A. P., … Richards, A. M., … Cameron, V. A., … Patel, R. (2020). Association of factor V Leiden with subsequent atherothrombotic events: A GENIUS-CHD study of individual participant data. Circulation, 142, 546-555. doi: 10.1161/circulationaha.119.045526

Verbree-Willemsen, L., Zhang, Y.-N., Ibrahim, I., Ooi, S. B. S., Wang, J.-W., Mazlan, M. I., … Richards, A. M., … de Kleijn, D. P. V. (2020). Extracellular vesicle Cystatin C and CD14 are associated with both renal dysfunction and heart failure. ESC Heart Failure, 7(5), 2240-2249. doi: 10.1002/ehf2.12699

Ouwerkerk, W., Teng, T.-H. K., Tromp, J., Tay, W. T., Cleland, J. G., van Veldhuisen, D. J., … Richards, A. M., … Lam, C. S. P. (2020). Effects of combined renin-angiotensin-aldosterone system inhibitor and beta-blocker treatment on outcomes in heart failure with reduced ejection fraction: Insights from BIOSTAT-CHF and ASIAN-HF registries. European Journal of Heart Failure, 22, 1472-1482. doi: 10.1002/ejhf.1869

Ellmers, L. J., Templeton, E. M., Pilbrow, A. P., Frampton, C., Ishii, I., Moore, P. K., Bhatia, M., Richards, A. M., & Cameron, V. A. (2020). Hydrogen sulfide treatment improves post-infarct remodeling and long-term cardiac function in CSE knockout and wild-type mice. International Journal of Molecular Sciences, 21(12), 4284. doi: 10.3390/ijms21124284

Tan, E. S. J., Goh, V., Santema, B. T., Tay, W. T., Teng, T.-H. K., Yap, J., … Richards, A. M., & Lam, C. S. P. (2020). Ethnic differences in atrial fibrillation among patients with heart failure in Asia. ESC Heart Failure, 7, 1419-1429. doi: 10.1002/ehf2.12696

Yip, C., Seneviratna, A., Tan, S.-H., Khaing, T., Chan, S.-P., Loh, J., … Richards, A. M., & Chan, M. Y. (2020). Patients with acute and chronic coronary syndromes have elevated long-term thrombin generation. Journal of Thrombosis & Thrombolysis, 50, 421-429. doi: 10.1007/s11239-020-02066-y

Pickering, J. W., Young, J. M., George, P. M., Pemberton, C. J., Watson, A., Aldous, S. J., … Troughton, R. W., Richards, A. M., … Than, M. P. (2020). Early kinetic profiles of troponin I and T measured by high-sensitivity assays in patients with myocardial infarction. Clinica Chimica Acta, 505, 15-25. doi: 10.1016/j.cca.2020.02.009

Appleby, S., Chew-Harris, J., Troughton, R. W., Richards, A. M., & Pemberton, C. J. (2020). Analytical and biological assessment of circulating human erythroferrone. Clinical Biochemistry, 79, 41-47. doi: 10.1016/j.clinbiochem.2020.02.001

Aimo, A., Januzzi, Jr, J. L., Vergaro, G., Richards, A. M., Lam, C. S. P., Latini, R., … Troughton, R., … Edmin, M. (2020). Circulating levels and prognostic value of soluble ST2 in heart failure are less influenced by age than N-terminal pro-B-type natriuretic peptide and high-sensitivity troponin T. European Journal of Heart Failure, 22, 2078-2088. doi: 10.1002/ejhf.1701

MacDonald, M. R., Tay, W. T., Teng, T.-H. K., Anand, I., Ling, L. H., Yap, J., … ASIAN-HF investigators, Richards, A. M., & Lam, C. S. P. (2020). Regional variation of mortality in heart failure with reduced and preserved ejection fraction across Asia: Outcomes in the ASIAN-HF registry. Journal of the American Heart Association, 9(1), e012199. doi: 10.1161/jaha.119.012199

Charles, C. J., Lee, P., Li, R. R., Yeung, T., Ibraham Mazlan, S. M., Tay, Z. W., … Richards, A. M. (2020). A porcine model of heart failure with preserved ejection fraction: Magnetic resonance imaging and metabolic energetics. ESC Heart Failure, 7, 93-103. doi: 10.1002/ehf2.12536

Woo, C. C., Liu, W., Lin, X. Y., Dorajoo, R., Lee, K. W., Richards, A. M., … Sorokin, V. (2020). The interaction between 30b-5p miRNA and MBNL1 mRNA is involved in vascular smooth muscle cell differentiation in patients with coronary atherosclerosis. International Journal of Molecular Sciences, 21, 11. doi: 10.3390/ijms21010011

Kuan, W. S., Ibrahim, I., Chan, S. P., Li, Z., Liew, O. W., Frampton, C., Troughton, R., Pemberton, C. J., … Richards, A. M. (2020). Mid-regional pro-adrenomedullin outperforms N-terminal pro-B-type natriuretic peptide for the diagnosis of acute heart failure in the presence of atrial fibrillation. European Journal of Heart Failure, 22, 692-700. doi: 10.1002/ejhf.1660

Mbikou, P., Rademaker, M. T., Charles, C. J., Richards, M. A., & Pemberton, C. J. (2020). Cardiovascular effects of DWORF (dwarf open reading frame) peptide in normal and ischaemia/reperfused isolated rat hearts. Peptides, 124, 170192. doi: 10.1016/j.peptides.2019.170192

Ong, C. W., Wee, I., Syn, N., Leo, H. L., Richards, A. M., & Choong, A. M. T. L. (2020). Computational fluid dynamics modelling of hemodynamic parameters in the human diseased aorta: A systematic review. Annals of Vascular Surgery, 63, 336-381. doi: 10.1016/j.avsg.2019.04.032

Journal - Research Other

Charles, C. J., Rademaker, M. T., Scott, N. J. A., & Richards, A. M. (2020). Large animal models of heart failure: Reduced vs. preserved ejection fraction. Animals, 10, 1906. doi: 10.3390/ani10101906

Richards, A. M. (2020). Beating the bushes for biomarkers. European Journal of Heart Failure, 22, 2075-2077. doi: 10.1002/ejhf.2004

Ouwerkerk, W., Tromp, J., Jin, X., Jaufeerally, F., Yeo, P. S. D., Leong, K. T. G., … Richards, A. M., & Lam, C. S. P. (2020). Heart failure with preserved ejection fraction diagnostic scores in an Asian population. European Journal of Heart Failure, 22(9), 1737-1739. doi: 10.1002/ejhf.1851

Lewis, L. K., Raudsepp, S. D., Prickett, T. C. R., Yandle, T. G., Pemberton, C. J., & Richards, A. M. (2020). ProBNP processing is decreased by obesity in patients with heart failure. Annals of Translational Medicine, 8(4), 135. doi: 10.21037/atm.2019.12.81

Adamson, P. D., Mills, N. L., Newby, D. E., Troughton, R. W., Doughty, R. N., & Richards, A. M. (2020). Response to: 'Convalescent troponin and cardiovascular death following acute coronary syndrome' by Kawada. Heart, 106(7), 545-546. doi: 10.1136/heartjnl-2020-316547

Sridharan, S., Kini, R. M., & Richards, A. M. (2020). Venom natriuretic peptides guide the design of heart failure therapeutics. Pharmacological Research, 155, 104687. doi: 10.1016/j.phrs.2020.104687

Teng, T.-H. K., Cooper, L., Tay, W. T., Luo, N., Sharma, A., Whellan, D., … Richards, A. M., … Lam, C. S. P. (2020). Association between body surface area and prescribed doses of guideline-directed medications among international patients with heart failure and reduced ejection fraction. European Journal of Heart Failure, 22(4), 754-758. doi: 10.1002/ejhf.1648

Conference Contribution - Published proceedings: Abstract

Chew-Harris, J., Appleby, S., Troughton, R. W., Richards, A. M., & Pemberton, C. J. (2020). Soluble urokinase plasminogen activator receptor (suPAR) can predict long-term mortality in patients with acute chest pain. European Heart Journal, 41(Suppl. 2), (pp. 1695). doi: 10.1093/ehjci/ehaa946.1695

Chew-Harris, J., Appleby, S., Kuan, W. S., Ibrahim, I., Chan, S. P., Li, Z., … Frampton, C., Troughton, R. W., … Richards, A. M., & Pemberton, C. J. (2020). Prognostic performance of soluble urokinase plasminogen activator receptor for 1-year mortality in Asian and Western patients with acute breathlessness. European Heart Journal, 41(Suppl. 2), (pp. 1202). doi: 10.1093/ehjci/ehaa946.1202

Chew-Harris, J., Appleby, S., Troughton, R. W., Richards, A. M., & Pemberton, C. J. (2020). Soluble urokinase plasminogen activator receptor (suPAR) predicts 2-year cardiovascular events in patients after acute chest pain. European Heart Journal, 41(Suppl. 2), (pp. 1696). doi: 10.1093/ehjci/ehaa946.1696

Adamson, P., Verryt, T., Frampton, C., Troughton, R., Doughty, R., & Richards, A. M. (2020). Sex differences in ventricular remodeling and long-term heart failure outcomes following acute coronary syndrome. Heart, Lung & Circulation, 29(Suppl. 1), (pp. S23-S24). doi: 10.1016/j.hlc.2020.05.060

Adamson, P., Verryt, T., Frampton, C., Troughton, R., Doughty, R., & Richards, A. M. (2020). Age-related differences in ventricular remodeling and long-term heart failure outcomes following acute coronary syndrome. Heart, Lung & Circulation, 29(Suppl. 1), (pp. S23). doi: 10.1016/j.hlc.2020.05.059

Evans, T., Poppe, K., Choi, C., Devlin, G., Lund, M., Troughton, R., Richards, A. M., & Doughty, R. N. (2020). Long-term outcomes for patients with heart failure in New Zealand according to ejection fraction phenotype. Heart, Lung & Circulation, 29(Suppl. 1), (pp. S21-S22). doi: 10.1016/j.hlc.2020.05.056

Evans, T., Poppe, K. K., Rolleston, A., Legget, M., Stubbs, M., Heath, M., … Richards, A. M., … Doughty, R. N. (2020). Cardiac biomarkers to guide risk in secondary prevention post-acute coronary syndromes. Heart, Lung & Circulation, 29(Suppl. 1), (pp. S7-S8). doi: 10.1016/j.hlc.2020.05.022

Lewis, L., Raudsepp, S. D., Yandle, T. G., Frampton, C. M., Richards, A. M., Prickett, T. C. R., … Pemberton, C. J. (2020). ProBNP glycosylation of threonine 71 is increased with obesity in patients with heart failure. European Heart Journal, 41(Suppl. 1), ehz872.007. doi: 10.1093/ehjci/ehz872.007

2019

Journal - Research Article

Poppe, K. K., Doughty, R. N., Wells, S., Wu, B., Earle, N. J., Richards, A. M., Troughton, R. W., … Kerr, A. J. (2019). Development and validation of a cardiovascular risk score for patients in the community after acute coronary syndrome. Heart, 106, 506-511. doi: 10.1136/heartjnl-2019-315809

Yap, J., Tay, W. T., Teng, T.-H. K., Anand, I., Richards, A. M., Ling, L. H., … Lam, C. S. P. (2019). Association of diabetes mellitus on cardiac remodeling, quality of life, and clinical outcomes in heart failure with reduced and preserved ejection fraction. Journal of the American Heart Association, 8(17), e013114. doi: 10.1161/JAHA.119.013114

Scott, N. J. A., Rademaker, M. T., Charles, C. J., Espiner, E. A., & Richards, A. M. (2019). Hemodynamic, hormonal, and renal actions of phosphodiesterase-9 inhibition in experimental heart failure. JACC, 74(7), 889-901. doi: 10.1016/j.jacc.2019.05.067

Adamson, P. D., McAllister, D., Pilbrow, A., Pickering, J. W., Poppe, K., Shah, A., Whalley, G., … Pemberton, C., Troughton, R. W., … Richards, A. M. (2019). Convalescent troponin and cardiovascular death following acute coronary syndrome. Heart, 105, 1717-1724. doi: 10.1136/heartjnl-2019-315084

Tromp, J., Lim, S. L., Tay, W. T., Teng, T.-H. K., Chandramouli, C., Ouwerkerk, W., … Richards, A. M., … on behalf of the ASIAN-HF investigators. (2019). Microvascular disease in patients with diabetes with heart failure and reduced ejection versus preserved ejection fraction. Diabetes Care, 42, 1792-1799. doi: 10.2337/dc18-2515

Tan, E. S. J., Chan, S. P., Xu, C. F., Yap, J., Richards, A. M., Ling, L. H., … Lim, T. W. (2019). Cornell product is an ECG marker of heart failure with preserved ejection fraction. Heart Asia, 11(1), e011108. doi: 10.1136/heartasia-2018-011108

Zhou, Y., Richards, A. M., & Wang, P. (2019). MicroRNA-221 is cardioprotective and anti-fibrotic in a rat model of myocardial infarction. Molecular Therapy: Nucleic Acids, 17, 185-197. doi: 10.1016/j.omtn.2019.05.018

Charles, C. J., Jardine, D. L., Rademaker, M. T., & Richards, A. M. (2019). Adrenomedullin 2 increases cardiac sympathetic nerve activity in parallel to heart rate in normal conscious sheep. Physiological Reports, 7(10), e14096. doi: 10.14814/phy2.14096

Chew-Harris, J., Appleby, S., Richards, A. M., Troughton, R. W., & Pemberton, C. J. (2019). Analytical, biochemical and clearance considerations of soluble urokinase plasminogen activator receptor (suPAR) in healthy individuals. Clinical Biochemistry, 69, 36-44. doi: 10.1016/j.clinbiochem.2019.05.010

Lewis, L. K., Raudsepp, S. D., Prickett, T. C. R., Yandle, T. G., Doughty, R. N., Frampton, C. M., Pemberton, C. J., & Richards, A. M. (2019). ProBNP that is not glycosylated at threonine 71 is decreased with obesity in patients with heart failure. Clinical Chemistry, 65(9), 1115-1124. doi: 10.1373/clinchem.2019.302547

Gallart-Palau, X., Tan, L. M., Serra, A., Gao, Y., Ho, H. H., Richards, A. M., … Sze, S. K. (2019). Degenerative protein modifications in the aging vasculature and central nervous system: A problem shared is not always halved. Ageing Research Reviews, 53, 100909. doi: 10.1016/j.arr.2019.100909

Wong, L. L., Saw, E. L., Lim, J. Y., Zhou, Y., Richards, A. M., & Wang, P. (2019). MicroRNA Let-7d-3p contributes to cardiac protection via targeting HMGA2. International Journal of Molecular Sciences, 20(7), 1522. doi: 10.3390/ijms20071522

Patel, R., Tragante, V., Schmidt, A. F., McCubrey, R. O., Holmes, M. V., Howe, L. J., … Pilbrow, A. P., … Richards, A. M., … Cameron, V. A., … Asselbergs, F. W. (2019). Subsequent event risk in individuals with established coronary heart disease: Design and rationale of the GENIUS-CHD Consortium. Circulation: Genomic & Precision Medicine, 12(4), 145-160. doi: 10.1161/CIRCGEN.119.002470

Wong, L. L., Zou, R., Zhou, L., Lim, J. Y., Phua, D. C. Y., Liu, C., … Troughton, R., Cameron, V. A., … Richards, A. M. (2019). Combining circulating microRNA and NT-proBNP to detect and categorize heart failure subtypes. JACC, 73(11), 1300-1313. doi: 10.1016/j.jacc.2018.11.060

Patel, R. S., Schmidt, A. F., Tragante, V., McCubrey, R. O., Holmes, M. V., Howe, L. J., … Pilbrow, A. P., … Richards, A. M., … Cameron, V. A., … Asselbergs, F. W. (2019). Association of chromosome 9p21 with subsequent coronary heart disease events: A GENIUS-CHD study of individual participant data. Circulation: Genomic & Precision Medicine, 12(4), 161-172. doi: 10.1161/circgen.119.002471

Lin, Z., Lim, S. H., Chua, S. J. T., Tai, E. S., Chan, Y. H., & Richards, A. M. (2019). High-sensitivity troponin T and long-term adverse cardiac events among patients presenting with suspected acute coronary syndrome in Singapore. Singapore Medical Journal, 60(8), 418-426. doi: 10.11622/smedj.2019013

Tan, E. S. J., Tay, W. T., Teng, T.-H. K., Sim, D., Leong, K. T. G., Yeo, P. S. D., … Troughton, R. W., … Richards, A. M., … Lam, C. S. P. (2019). Ethnic differences in atrial fibrillation in patients with heart failure from Asia-Pacific. Heart, 105, 842-847. doi: 10.1136/heartjnl-2018-314077

Ellis, C. J., Gamble, G. D., Williams, M. J. A., Matsis, P., Elliott, J. M., Devlin, G., Mann, S., … for the Regional Cardiac Society NZ ACS Audit Group, including Richards, M., & Nixon, G. (2019). All-cause mortality following an acute coronary syndrome: 12-year follow-up of the comprehensive 2002 New Zealand Acute Coronary Syndrome Audit. Heart, Lung & Circulation, 28(2), 245-256. doi: 10.1016/j.hlc.2017.10.015

Marchesseau, S., Totman, J. J., Fadil, H., Leek, F. A. A., Chaal, J., Richards, M., … Reilhac, A. (2019). Cardiac motion and spillover correction for quantitative PET imaging using dynamic MRI. Medical Physics, 46(2), 726-737. doi: 10.1002/mp.13345

Chandramouli, C., Teng, T.-H. K., Tay, W. T., Yap, J., MacDonald, M. R., Tromp, J., … Richards, A. M., … on behalf of the ASIAN-HF investigators. (2019). Impact of diabetes and sex in heart failure with reduced ejection fraction patients from the ASIAN-HF registry. European Journal of Heart Failure, 21(3), 297-307. doi: 10.1002/ejhf.1358

Tromp, J., Teng, T.-H., Tay, W. T., Hung, C. L., Narasimhan, C., Shimizu, W., … Richards, A. M., … on behalf of the ASIAN-HF investigators. (2019). Heart failure with preserved ejection fraction in Asia. European Journal of Heart Failure, 21(1), 23-36. doi: 10.1002/ejhf.1227

Journal - Research Other

Chen, Y.-T., Wong, L. L., Liew, O. W., & Richards, A. M. (2019). Heart failure with reduced ejection fraction (HFrEF) and preserved ejection fraction (HFpEF): The diagnostic value of circulating microRNAs. Cells, 8(12), 1651. doi: 10.3390/cells8121651

Richards, A. M., & Januzzi, Jr, J. L. (2019). Are some patients with acute heart failure ANP-deficient? JACC: Heart Failure, 7(10), 899-901. doi: 10.1016/j.jchf.2019.07.003

Stamp, L. K., Frampton, C., Drake, J., Doughty, R. N., Troughton, R. W., & Richards, A. M. (2019). Associations of gout and baseline serum urate with cardiovascular outcomes: Analysis of the Coronary Disease Cohort Study. Arthritis & Rheumatology, 71(10), 1733-1738. doi: 10.1002/art.41007

Tan, E. S. J., Tay, W. T., Teng, T.-H. K., Richards, A. M., Doughty, R. N., & Lam, C. S. P. (2019). The diabetes-atrial fibrillation paradox. Heart, 105(11), 893. doi: 10.1136/heartjnl-2019-315018

Dong, Y., Teo, S. Y., Kang, K., Tan, M., Ling, L. H., Yeo, P. S. D., … Richards, A. M., & Lam, C. S. P. (2019). Cognitive impairment in Asian patients with heart failure: Prevalence, biomarkers, clinical correlates, and outcomes. European Journal of Heart Failure, 21(5), 688-690. doi: 10.1002/ejhf.1442

Richards, A. M., Pemberton, C., & Yandle, T. (2019). How does neprilysin inhibition in heart failure work? European Journal of Heart Failure, 21(5), 606-608. doi: 10.1002/ejhf.1454

Conference Contribution - Published proceedings: Abstract

Pemberton, C. J., Lee, J. A., Aldous, S., Appleby, S., Chew-Harris, J., Than, M., Troughton, R. W., & Richards, A. M. (2019). The signal peptide of CNP is a novel predictor of MI, MACE and bleeding risk in chest pain patients. European Heart Journal, 40(Suppl. 1), (pp. 2029). doi: 10.1093/eurheartj/ehz745.0283

Chew-Harris, J. S., Appleby, S., Richards, A. M., Troughton, R. W., & Pemberton, C. J. (2019). Soluble urokinase plasminogen activator receptor (suPAR) predicts 1 year mortality in patients with acute breathlessness. European Heart Journal, 40(Suppl. 1), (pp. 1573). doi: 10.1093/eurheartj/ehz748.0939

Pemberton, C. J., Lee, J. A., Aldous, S., Skelton, L., Frampton, C. M., Than, M., Troughton, R. W., Adamson, P., & Richards, A. M. (2019). The protein APRIL predicts adverse outcomes in DAPT patients better than NT-proBNP and troponin. European Heart Journal, 40(Suppl. 1), (pp. 1052). doi: 10.1093/eurheartj/ehz748.0509

Aldous, S., Pickering, J., Young, J., George, P., Watson, A., Troughton, R., Pemberton, C., Richards, M., … Than, M. (2019). Rapid rule-out of myocardial infarction with a novel high precision point-of-care troponin assay appears safe and effective. European Heart Journal, 40(Suppl. 1), (pp. 1626). doi: 10.1093/eurheartj/ehz748.0992

Singh, S., Ronde, M. W. J., Creemers, E. E., Chan, M. Y., Hwee, T. S., Chin, C. T., Richards, A. M., Troughton, R. W., … Pinto, S. J. (2019). Low miR-19b-1-5p expression in ACS patients is related to aspirin resistance and major adverse cardio-cerebrovascular event (MACCE). European Heart Journal, 40(Suppl. 1), (pp. 4195). doi: 10.1093/eurheartj/ehz746.1189

Sock Hwee, T., Koh, H. W. L., Chua, J. Y., Yang, X. X., Ong, C. C., Teo, L., … Pilbrow, A. P., Pickering, J. W., Troughton, R. W., … Richards, A. M., & Chan, M. Y. (2019). Plasma proteomics identify plaque-related proteins that predict long-term recurrent coronary events in patients with acute coronary syndrome. European Heart Journal, 40(Suppl. 1), (pp. 3588). doi: 10.1093/eurheartj/ehz746.0660

Singh, S., de Ronde, M. W. J., Creemers, E. E., Chan, M. Y., Tan, S. H., Chin, C. T., Richards, A. M., Troughton, R. W., … Pinto-Sietsma, S. J. (2019). Low miR-19b-1-5p expression in ACS patients is related to aspirin resistance and major adverse cardio-cerebrovascular event (MACCE). Atherosclerosis, 287, (pp. e142). doi: 10.1016/j.atherosclerosis.2019.06.422

Conference Contribution - Verbal presentation and other Conference outputs

Charles, C. J., Lee, P., Li, R. R., Yeung, T., Mazlan, S. M. I., Tay, Z. W., … Richards, A. M. (2019, September). A porcine model of heart failure with preserved ejection fraction: Characterization with MRI metabolic energetics. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

2018

Journal - Research Article

Jiang, X., Lew, K.-S., Chen, Q., Richards, A. M., & Wang, P. (2018). Human mesenchymal stem cell-derived exosomes reduce ischemia/reperfusion injury by the inhibitions of apoptosis and autophagy. Current Pharmaceutical Design, 24(44), 5334-5341. doi: 10.2174/1381612825666190119130441

Tromp, J., MacDonald, M. R., Tay, W. T., Teng, T.-H. K., Hung, C.-L., Narasimhan, C., … Richards, A. M., … Lam, C. S. P. (2018). Heart failure with preserved ejection fraction in the young. Circulation, 138(24), 2763-2773. doi: 10.1161/CIRCULATIONAHA.118.034720

Tan, L.-L., Ting, J., Balakrishnan, I., Seneviratne, A., Gong, L., Chan, M. Y., … Richards, A. M., … Lee, C.-H. (2018). Sleep apnea evolution and left ventricular recovery after percutaneous coronary intervention for myocardial infarction. Journal of Clinical Sleep Medicine, 14(10), 1773-1781. doi: 10.5664/jcsm.7394

Pickering, J. W., Young, J. M., George, P. M., Watson, A. S., Aldous, S. J., Troughton, R. W., Pemberton, C. J., Richards, A. M., … Than, M. P. (2018). Validity of a novel point-of-care troponin assay for single-test rule-out of acute myocardial infarction. JAMA Cardiology, 3(11), 1108-1112. doi: 10.1001/jamacardio.2018.3368

Charles, C. J., Jardine, D. L., Rademaker, M. T., & Richards, A. M. (2018). Systemic Angiotensin II does not increase cardiac sympathetic nerve activity in normal conscious sheep. Bioscience Reports, 38(5), BSR20180513. doi: 10.1042/bsr20180513

Marks, E. C. A., Wilkinson, T. M., Frampton, C. M., Skelton, L., Pilbrow, A. P., Yandle, T. G., Pemberton, C. J., … Whalley, G. A., … Troughton, R. W., … Cameron, V. A., Richards, A. M., Gieseg, S. P., & Palmer, B. R. (2018). Plasma levels of soluble VEGF receptor isoforms, circulating pterins and VEGF system SNPs as prognostic biomarkers in patients with acute coronary syndromes. BMC Cardiovascular Disorders, 18, 169. doi: 10.1186/s12872-018-0894-1

Teng, T.-H. K., Tromp, J., Tay, W. T., Anand, I., Ouwerkerk, W., Chopra, V., … Richards, A. M., … Lam, C. S. P. (2018). Prescribing patterns of evidence-based heart failure pharmacotherapy and outcomes in the ASIAN-HF registry: A cohort study. Lancet Global Health, 6(9), e1008-e1018. doi: 10.1016/S2214-109X(18)30306-1

Zhou, Y., Shiok, T. C., Richards, A. M., & Wang, P. (2018). MicroRNA-101a suppresses fibrotic programming in isolated cardiac fibroblasts and in vivo fibrosis following trans-aortic constriction. Journal of Molecular & Cellular Cardiology, 121, 266-276. doi: 10.1016/j.yjmcc.2018.07.251

Than, M. P., Aldous, S. J., Troughton, R. W., Pemberton, C. J., Richards, A. M., Frampton, C. M. A., Florkowski, C. M., George, P. M., … Young, J. M., … Pickering, J. W. (2018). Detectable high-sensitivity cardiac troponin within the population reference interval conveys high 5-year cardiovascular risk: An observational study. Clinical Chemistry, 64(7), 1044-1053. doi: 10.1373/clinchem.2017.285700

Wang, J., Tong, K. S., Wong, L. L., Liew, O.-W., Raghuram, D., Richards, A. M., & Chen, Y.-T. (2018). MicroRNA-143 modulates the expression of Natriuretic Peptide Receptor 3 in cardiac cells. Scientific Reports, 8, 7055. doi: 10.1038/s41598-018-25489-3

van der Linden, N., Wildi, K., Twerenbold, R., Pickering, J. W., Than, M., Cullen, L., … Richards, A. M., Troughton, R., Pemberton, C., … Mueller, C. (2018). Combining high sensitivity cardiac troponin I and cardiac troponin T in the early diagnosis of acute myocardial infarction. Circulation, 138(10), 989-999. doi: 10.1161/circulationaha.117.032003

de Carvalho, L. P., Tan, S. H., Ow, G.-S., Tang, Z., Ching, J., Kovalik, J.-P., … Richards, A. M., … Troughton, R. W., … Chan, M. Y. (2018). Plasma ceramides as prognostic biomarkers and their arterial and myocardial tissue correlates in acute myocardial infarction. JACC: Basic to Translational Science, 3(2), 163-175. doi: 10.1016/j.jacbts.2017.12.005

Goh, V. J., Tromp, J., Teng, T.-H., Tay, W. T., van der Meer, P., Ling, L. H., … Richards, M. A., … on behalf of the ASIAN-HF investigators. (2018). Prevalence, clinical correlates, and outcomes of anaemia in multi-ethnic Asian patients with heart failure with reduced ejection fraction. ESC Heart Failure, 5(4), 570-578. doi: 10.1002/ehf2.12279

de Carvalho, L., Fong, A., Troughton, R., Yan, B. P., Chin, C.-T., Poh, S.-C., … Frampton, C., Richards, A. M., & Chan, M. Y. (2018). Prognostic implications of dual platelet reactivity testing in acute coronary syndrome. Thrombosis & Haemostasis, 118(2), 415-426. doi: 10.1160/TH17-08-0564

Lam, C. S. P., Gamble, G. D., Ling, L. H., Sim, D., Leong, K. T. G., Yeo, P. S. D., … Cameron, V. A., … Troughton, R., Richards, A. M., & Doughty, R. N. (2018). Mortality associated with heart failure with preserved vs. reduced ejection fraction in a prospective international multi-ethnic cohort study. European Heart Journal, 39(20), 1170-1178. doi: 10.1093/eurheartj/ehy005

McDonald, K., Troughton, R., Dahlström, U., Dargie, H., Krum, H., van der Meer, P., … Richards, M., & Doughty, R. (2018). Daily home BNP monitoring in heart failure for prediction of impending clinical deterioration: Results from the HOME HF study. European Journal of Heart Failure, 20(3), 474-480. doi: 10.1002/ejhf.1053

Joo Yeo, T., Yeo, P. S. D., Hadi, F. A., Cushway, T., Lee, K. Y., Yin, F. F., … Richards, A. M., & Lam, C. S. P. (2018). Single-dose intravenous iron in Southeast Asian heart failure patients: A pilot randomized placebo-controlled study (PRACTICE-ASIA-HF). ESC Heart Failure, 5(2), 344-353. doi: 10.1002/ehf2.12250

Pickering, J. W., Flaws, D., Smith, S. W., Greenslade, J., Cullen, L., Parsonage, W., … Richards, A. M., Troughton, R., Pemberton, C., George, P. M., & Than, M. P. (2018). A risk assessment score and initial high-sensitivity troponin combine to identify low risk of acute myocardial infarction in the emergency department. Academic Emergency Medicine, 25(4), 434-443. doi: 10.1111/acem.13343

Than, M. P., Pickering, J. W., Dryden, J. M., Lord, S. J., Aitken, S. A., Aldous, S. J., … Ardagh, M. W., … Callender, R., … Deely, J. M., … Ferrier, K. A., … Frampton, C. M. A., George, P. M., … Matthews, T. J. E., … Peckler, B. F., … Richards, A. M., … Simmonds, M. B., … Troughton, R. W., … on behalf of the ICare-ACS Implementation Group. (2018). ICare-ACS (improving care processes for patients with suspected acute coronary syndrome): A study of cross-system implementation of a national clinical pathway. Circulation, 137(4), 354-363. doi: 10.1161/circulationaha.117.031984

de Hoog, V. C., Lim, S. H., Bank, I. E. M., Gijsberts, C., Ibrahim, I. B., Kuan, W. S., … Richards, A. M., … Timmers, L. (2018). HEART score performance in Asian and Caucasian patients presenting to the emergency department with suspected acute coronary syndrome. European Heart Journal, 7(7), 591-601. doi: 10.1177/2048872617700870

Bayes-Genis, A., Voors, A. A., Zannad, F., Januzzi, J. L., Richards, A. M., & Díez, J. (2018). Transitioning from usual care to biomarker-based personalized and precision medicine in heart failure: Call for action. European Heart Journal, 39(30), 2793-2799. doi: 10.1093/eurheartj/ehx027

Journal - Research Other

Richards, A. M. (2018). ST2 and prognosis in chronic heart failure. JACC, 72(19), 2321-2323. doi: 10.1016/j.jacc.2018.08.2164

Richards, A. M. (2018). Future biomarkers in cardiology: My favourites. European Heart Journal Supplements, 20(Suppl. G), G37-G44. doi: 10.1093/eurheartj/suy023

Januzzi, J. L., & Richards, A. M. (2018). Natriuretic peptide-guided heart failure therapy after the GUIDE-IT Study. Circulation, 137(20), 2101-2103. doi: 10.1161/circulationaha.118.033853

Chua, A.-P., Koo, C.-Y., Kristanto, W., Parot, M. V. J. M., Tan, E. S.-T., Koh, E. H.-T., … Frampton, C., Richards, A. M., & Lee, C.-H. (2018). Sleep Study-Guided Multidisciplinary Therapy (SGMT) for patients with acute coronary syndrome: Trial rationale and design. Clinical Cardiology, 41(6), 721-728. doi: 10.1002/clc.22950

Wong, L. L., & Richards, A. M. (2018). Harnessing the power of microRNAs as prognostic biomarkers in acute heart failure. European Journal of Heart Failure, 20(1), 97-99. doi: 10.1002/ejhf.993

Conference Contribution - Published proceedings: Abstract

Chew-Harris, J., Appleby, S., Troughton, R., Richards, M., & Pemberton, C. (2018). Soluble urokinase plasminogen activator receptor is a strong prognostic indicator of mortality in acutely breathless patients. Circulation, 138(Suppl. 1), A11125. [Abstract]

Appleby, S., Chew-Harris, J., Troughton, R., Richards, M., & Pemberton, C. (2018). Erythroferrone can diagnose acute decompensated heart failure in patients presenting with breathlessness. Circulation, 138(Suppl. 1), A11094. [Abstract]

Ong, C., Piebalgs, A., Menichini, C., Wee, I., Xu, X., Gibbs, R., Richards, A. M., … Choong, A. M. T. L. (2018). A numerical study assessing the hemodynamic differences between two different configurations of ‘visceral hybrid’ repairs of thoracoabdominal aneurysms. Proceedings of the 8th World Congress of Biomechanics. Retrieved from www.wbc2018.com

Pemberton, C. J., Lee, J. A., Jardine, R., Skelton, L., Frampton, C. M., Troughton, R. W., Richards, A. M., on behalf of Christchurch Heart Institute. (2018). The TNF receptor TACI is a novel inflammatory predictor of heart failure. European Heart Journal, 39(Suppl. 1), (pp. 576-577). doi: 10.1093/eurheartj/ehy565.P2791

Nanayakkara, S., Pemberton, C., Patel, H., Vizi, D., Mak, V., Richards, A. M., … Kaye, D. M. (2018). Mid regional atrial natriuretic peptide is an independent predictor of peak pulmonary capillary wedge pressure in patients with heart failure with preserved ejection fraction. European Heart Journal, 39(Suppl. 1), (pp. 222). doi: 10.1093/eurheartj/ehy565.1096

Poppe, K., Doughty, R., Wells, S., Richards, M., Troughton, R., Earle, N., … Kerr, A. (2018). Development and validation of a risk score for patients back in the community after an acute coronary syndrome event. Heart, Lung & Circulation, 27(Suppl. 1), (pp. S21). doi: 10.1016/j.hlc.2018.05.145

Aldous, S., Pickering, J., Cullen, L., Richards, M., & Than, M. (2018). The investigation and treatment of women who present with acute chest pain, varies little compared with men when stratified by risk. Heart, Lung & Circulation, 27(Suppl. 1), (pp. S8). doi: 10.1016/j.hlc.2018.05.118

Conference Contribution - Poster Presentation (not in published proceedings)

Chew-Harris, J., Appleby, S., Troughton, R., Richards, M., & Pemberton, C. (2018, August). Soluble urokinase plasminogen activator receptor is a strong prognostic indicator of mortality in acutely breathless patients. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2017

Chapter in Book - Research

Pemberton, C. J., Charles, C. J., & Richards, A. M. (2017). Cardiac natriuretic peptides. In J. C. Schisler, C. H. Lang & M. S. Willis (Eds.), Endocrinology of the heart in health and disease. (pp. 3-39). Elsevier. doi: 10.1016/B978-0-12-803111-7.00001-4

Journal - Research Article

Hu, Y.-J., Schmidt, A. F., Dudbridge, F., Holmes, M. V., Brophy, J. M., Tragante, V., … on behalf of the GENIUS-CHD Consortium, including Cameron, V. A., Pilbrow, A. P., & Richards, A. M. (2017). Impact of selection bias on estimation of subsequent event risk. Circulation: Cardiovascular Genetics, 10(5), e001616. doi: 10.1161/CIRCGENETICS.116.001616

Richards, A. M. (2017). N-terminal B-type natriuretic peptide in heart failure. Heart Failure Clinics, 14(1), 27-39. doi: 10.1016/j.hfc.2017.08.004

Chia, Y. M. F., Teng, T.-H. K., Tan, E. S. J., Tay, W. T., Richards, A. M., Chin, C. W. L., … Lam, C. S. P. (2017). Disparity between indications for and utilization of implantable cardioverter defibrillators in Asian patients with heart failure. Circulation: Cardiovascular Quality & Outcomes, 10(11), e004304. doi: 10.1161/circoutcomes.116.003651

Martinez, E. C., Lilyanna, S., Wang, P., Vardy, L. A., Jiang, X., Armugam, A., … Richards, A. M. (2017). MicroRNA-31 promotes adverse cardiac remodeling and dysfunction in ischemic heart disease. Journal of Molecular & Cellular Cardiology, 112, 27-39. doi: 10.1016/j.yjmcc.2017.08.013

Wong, L. L., Rademaker, M. T., Saw, E. L., Lew, K. S., Ellmers, L. J., Charles, C. J., Richards, A. M., & Wang, P. (2017). Identification of novel microRNAs in the sheep heart and their regulation in heart failure. Scientific Reports, 7(1), 8250. doi: 10.1038/s41598-017-08574-x

Zhou, Y., Richards, A. M., & Wang, P. (2017). Characterization and standardization of cultured cardiac fibroblasts for ex vivo models of heart fibrosis and heart ischemia. Tissue Engineering Part C: Methods, 23(7), 422-433. doi: 10.1089/ten.tec.2017.0169

Scott, N. J. A., Ellmers, L. J., Pilbrow, A. P., Thomsen, L., Richards, A. M., Frampton, C. M., & Cameron, V. A. (2017). Metabolic and blood pressure effects of walnut supplementation in a mouse model of the metabolic syndrome. Nutrients, 9, 722. doi: 10.3390/nu9070722

Ling, S. S. M., Chen, Y.-T., Wang, J., Richards, A. M., & Liew, O. W. (2017). Ankyrin repeat domain 1 protein: A functionally pleiotropic protein with cardiac biomarker potential. International Journal of Molecular Sciences, 18(7), 1362. doi: 10.3390/ijms18071362

Luo, N., Teng, T.-H. K., Tay, W. T., Anand, I. S., Kraus, W. E., Liew, H. B., … Richards, A. M., … Mentz, R. J. (2017). Multinational and multiethnic variations in health-related quality of life in patients with chronic heart failure. American Heart Journal, 191, 75-81. doi: 10.1016/j.ahj.2017.06.016

Drum, C. L., Tan, W. K. Y., Chan, S.-P., Pakkiri, L. S., Chong, J. P. C., Liew, O.-W., … Richards, A. M. (2017). Thymosin beta-4 is elevated in women with heart failure with preserved ejection fraction. Journal of the American Heart Association, 6(6), e005586. doi: 10.1161/jaha.117.005586

Bosch, L., Lam, C. S. P., Gong, L., Chan, S. P., Sim, D., Yeo, D., … Richards, A. M., … Ling, L. H. (2017). Right ventricular dysfunction in left-sided heart failure with preserved versus reduced ejection fraction. European Journal of Heart Failure, 19(12), 1664-1671. doi: 10.1002/ejhf.873

Zewinger, S., Kleber, M. E., Tragante, V., McCubrey, R. O., Schmidt, A. F., Direk, K., … Pilbrow, A. P., Cameron, V. A., Richards, A. M., … on behalf of the GENIUS-CHD consortium, … Speer, T. (2017). Relations between lipoprotein(a) concentrations, LPA genetic variants, and the risk of mortality in patients with established coronary heart disease: A molecular and genetic association study. Lancet Diabetes & Endocrinology, 5(7), 534-543. doi: 10.1016/S2213-8587(17)30096-7

Ng, G., Boey, E., Frampton, C., Richards, A. M., Yeo, T.-C., & Lee, C.-H. (2017). Obstructive sleep apnea is associated with visit-to-visit variability in low-density lipoprotein-cholesterol in patients with coronary artery disease. Sleep & Breathing, 21(2), 271-278. doi: 10.1007/s11325-016-1394-0

Pickering, J. W., Than, M. P., Cullen, L., Aldous, S., ter Avest, E., Body, R., … Florkowski, C. M., … George, P., … Pemberton, C., Richards, A. M., … Troughton, R., … Young, J. (2017). Rapid rule-out of acute myocardial infarction with a single high-sensitivity cardiac troponin T measurement below the limit of detection: A collaborative meta-analysis. Annals of Internal Medicine, 166(10), 715-724. doi: 10.7326/m16-2562

Lewis, L. K., Raudsepp, S. D., Yandle, T. G., Prickett, T. C., & Richards, A. M. (2017). Development of a BNP1-32 immunoassay that does not cross-react with proBNP. Clinical Chemistry, 63(6), 1110-1117. doi: 10.1373/clinchem.2016.269712

Elliott, J. M., Wang, T. K. M., Gamble, G., Williams, M., Matsis, P., Troughton, R., … Mann, S., Richards, M., … Ellis, C. (2017). A decade of improvement in the management of New Zealand ST-elevation myocardial infarction (STEMI) patients: Results from the New Zealand Acute Coronary Syndrome (ACS) Audit Group national audits of 2002, 2007 and 2012. New Zealand Medical Journal, 130(1453), 17-28. Retrieved from https://www.nzma.org.nz/journal

Vasudevan, V., Low, A. J. J., Annamalai, S. P., Sampath, S., Poh, K. K., Totman, T., … Richards, A. M., … Yap, C. H. (2017). Flow dynamics and energy efficiency of flow in the left ventricle during myocardial infarction. Biomechanics & Modeling in Mechanobiology, 16(5), 1503-1517. doi: 10.1007/s10237-017-0902-x

Leong, K. T. G., Wong, L. Y., Aung, K. C. Y., Macdonald, M., Cao, Y., Lee, S., … Richards, A. M. (2017). Risk stratification model for 30-day heart failure readmission in a multiethnic South East Asian community. American Journal of Cardiology, 119(9), 1428-1432. doi: 10.1016/j.amjcard.2017.01.026

Chen, Y.-T., Wang, J., Tong, K. S., Wong, L. L., Liew, O. W., & Richards, A. M. (2017). The association of heart failure-related microRNAs with neurohormonal signaling. Biochimica et Biophysica Acta: Molecular Basis of Disease, 1863(8), 2031-2040. doi: 10.1016/j.bbadis.2016.12.019

Prickett, T. C. R., Doughty, R. N., Troughton, R. W., Frampton, C. M., Whalley, G. A., Ellis, C. J., Espiner, E. A., & Richards, A. M. (2017). C-type natriuretic peptides in coronary disease. Clinical Chemistry, 63(1), 316-324. doi: 10.1373/clinchem.2016.257816

Bank, I. E. M., Gijsberts, C. M., Teng, T.-H. K., Benson, L., Sim, D., Yeo, P. S. D., … Richards, A. M., … Lam, C. S. P. (2017). Prevalence and clinical significance of diabetes in Asian versus white patients with heart failure. JACC: Heart Failure, 5(1), 14-24. doi: 10.1016/j.jchf.2016.09.015

Liebetrau, C., Gaede, L., Wolter, J. S., Homann, J., Meyer, A., Dörr, O., … Richards, A. M., & Pemberton, C. J. (2017). Release kinetics of high-sensitivity cardiac troponins I and T and troponin T upstream open reading frame peptide (TnTuORF) in clinically induced acute myocardial infarction. Biomarkers, 22(3-4), 304-310. doi: 10.1080/1354750X.2016.1252965

Ibrihim, I., Kuan, W. S., Frampton, C., Troughton, R., Liew, O. W., Chong, J. P. C., … Pemberton, C. J., … Richards, A. M. (2017). Superior performance of N-terminal pro brain natriuretic peptide for diagnosis of acute decompensated heart failure in an Asian compared with a Western setting. European Journal of Heart Failure, 19(2), 209-217. doi: 10.1002/ejhf.612

Journal - Research Other

Rademaker, M. T., & Richards, A. M. (2017). Urocortins: Actions in health and heart failure. Clinica Chimica Acta, 474, 76-87. doi: 10.1016/j.cca.2017.09.003

Bosch, L., Carluccio, E., Coiro, S., Gong, L., Sim, D., Yeo, D., … Richards, A. M., … Ambrosio, G. (2017). Risk stratification of Asian patients with heart failure and reduced ejection fraction: The effectiveness of the Echo Heart Failure Score. European Journal of Heart Failure, 19(12), 1732-1735. doi: 10.1002/ejhf.922

Laribi, S., Pemberton, C. J., Kirwan, L., Nouira, S., Turkdogan, K., Yilmaz, M. B., Troughton, R. W., … Richards, M., … on behalf of the GREAT (Global Research on Acute Conditions Team) Network. (2017). Mortality and acute exacerbation of COPD: A pilot study on the influence of myocardial injury. European Respiratory Journal, 49(6), 1700096. doi: 10.1183/13993003.00096-2017

Richards, A. M. (2017). Circulating biomarkers of cardiac fibrosis: Do we have any and what use are they? Circulation: Heart Failure, 10(3), e003936. doi: 10.1161/circheartfailure.117.003936

Conference Contribution - Published proceedings: Abstract

Aldous, S., Pickering, J., Richards, M., Troughton, R., Cullen, L., & Than, M. (2017). Comparison of five accelerated diagnostic protocols for stratification of patients presenting with acute chest pain. Heart, Lung & Circulation, 26(Suppl. 1). doi: 10.1016/j.hlc.2017.05.038

Conference Contribution - Verbal presentation and other Conference outputs

Pilbrow, A. P., Runesson, A. S. D., Sommer, M. A. W., Jones, G. T., Frampton, C. M., Pemberton, C. J., Troughton, R. W., Richards, A. M., & Cameron, V. A. (2017, September). Using microRNAs to predict heart disease events in the general population. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Intellectual Property

Pemberton, C. J., Richards, A. M., Nicholls, M. G., & Yandle, T. G. (2017). Biomarkers. [Marker reference: INSDx] (9,630,985). United States.

2016

Journal - Research Article

Pokorney, S. D., Piccini, J. P., Stevens, S. R., Patel, M. R., Pieper, K. S., Halperin, J. L., … for the ROCKET AF Steering Committee & Investigators, including Richards, M., Mann, S., & Wilkins, G. (2016). Cause of death and predictors of all-cause mortality in anticoagulated patients with nonvalvular atrial fibrilation: Data from ROCKET AF. Journal of the American Heart Association, 5(3), e002197. doi: 10.1161/JAHA.115.002197

Young, J. M., Pickering, J. W., George, P. M., Aldous, S. J., Wallace, J., Frampton, C. M., Troughton, R. W., Richards, A. M., … Than, M. P. (2016). Heart Fatty Acid Binding Protein and cardiac troponin: Development of an optimal rule-out strategy for acute myocardial infarction. BMC Emergency Medicine, 16(1), 34. doi: 10.1186/s12873-016-0089-y

Bayes-Genis, A., Barallat, J., & Richards, A. M. (2016). A test in context: Neprilysin: Function, inhibition, and biomarker. JACC, 68(6), 639-653. doi: 10.1016/j.jacc.2016.04.060

Gijsberts, C. M., Benson, L., Dahlström, U., Sim, D., Yeo, D. P. S., Ong, H. Y., … Richards, A. M., … Lam, C. S. P. (2016). Ethnic differences in the association of QRS duration with ejection fraction and outcome in heart failure. Heart, 102(18), 1464-1471. doi: 10.1136/heartjnl-2015-309212

Wang, J., Liew, O. W., Richards, A. M., & Chen, Y.-T. (2016). Overview of microRNAs in cardiac hypertrophy, fibrosis, and apoptosis. International Journal of Molecular Sciences, 17(5), 749. doi: 10.3390/ijms17050749

Chen, Y.-T., Wang, J., Wee, A. S. Y., Yong, Q.-W., Tay, E. L.-W., Woo, C. C., … Richards, A. M., & Ling, L.-H. (2016). Differential MicroRNA expression profile in myxomatous mitral valve prolapse and fibroelastic deficiency valves. International Journal of Molecular Sciences, 17(5), 753. doi: 10.3390/ijms17050753

Yap, J., Jin, A. Z., Nyunt, S. Z., Ng, T. P., Richards, A. M., & Lam, C. S. P. (2016). Longitudinal community-based study of QT interval and mortality in Southeast Asians. PLoS ONE, 11(5), e0154901. doi: 10.1371/journal.pone.0154901

Liew, O. W., Yandle, T. G., Chong, J. P. C., Ng, Y. X., Frampton, C. M., Ng, T. P., … Richards, A. M. (2016). High-sensitivity sandwich ELISA for plasma NT-proUcn2: Plasma concentrations and relationship to mortality in heart failure. Clinical Chemistry, 62(6), 856-865. doi: 10.1373/clinchem.2015.252932

Chen, Q., Zhou, Y., Richards, A. M., & Wang, P. (2016). Up-regulation of miRNA-221 inhibits hypoxia/reoxygenation-induced autophagy through the DDIT4/mTORC1 and Tp53inp1/p62 pathways. Biochemical & Biophysical Research Communications, 474(1), 168-174. doi: 10.1016/j.bbrc.2016.04.090

Wong, L. L., Wang, J., Liew, O. W., Richards, A. M., & Chen, Y.-T. (2016). MicroRNA and heart failure. International Journal of Molecular Sciences, 17(4), 502, 502. doi: 10.3390/ijms17040502

Santhanakrishnan, R., Wang, N., Larson, M. G., Magnani, J. M., Vasan, R. S., Wang, T. J., … Richards, A. M., … Ho, J. E. (2016). Racial differences in electrocardiographic characteristics and prognostic significance in Whites versus Asians. Journal of the American Heart Association, 5(3), e002956. doi: 10.1161/jaha.115.002956

Than, M. P., Pickering, J. W., Aldous, S. J., Cullen, L., Frampton, C. M. A., Peacock, W. F., … Richards, A. M., Ardagh, M. W., Deely, J. M., Florkowski, C. M., George, P., Hamilton, G. J., Jardine, D. L., Troughton, R. W., … Lord, S. J. (2016). Effectiveness of EDACS versus ADAPT accelerated diagnostic pathways for chest pain: A pragmatic randomized controlled trial embedded within practice. Annals of Emergency Medicine, 68(1), 93-102. doi: 10.1016/j.annemergmed.2016.01.001

Pemberton, C. J., Frampton, C. M., Aldous, S., Bailey, M., Young, J., Troughton, R., Than, M., & Richards, M. (2016). B-type natriuretic peptide signal peptide (BNPsp) in patients presenting with chest pain. Clinical Biochemistry, 49, 645-650. doi: 10.1016/j.clinbiochem.2016.02.015

Tan, E. S. J., Yap, J., Xu, C. F., Feng, L., Nyunt, S. Z., Santhanakrishnan, R., … Richards, A. M., … Lam, C. S. P. (2016). Association of age, sex, body size and ethnicity with electrocardiographic values in community-based older Asian adults. Heart, Lung & Circulation, 25(7), 705-711. doi: 10.1016/j.hlc.2016.01.015

Zhang, Y.-N., Vernooij, F., Ibrahim, I., Ooi, S., Gijsberts, C. M., Schoneveld, A. H., … Richards, A. M., … de Kleijn, D. P. V. (2016). Extracellular vesicle proteins associated with systemic vascular events correlate with heart failure: An observational study in a dyspnoea cohort. PLoS ONE, 11(1), e0148073. doi: 10.1371/journal.pone.0148073

Devlin, G., Williams, M., Elliott, J., White, H., French, J., Gamble, G., Matsis, P., Troughton, R., Richards, M., & Ellis, C. (2016). Management of non ST-elevation acute coronary syndrome patients in New Zealand: A longitudinal analysis: Results from the New Zealand Acute Coronary Syndrome national audits of 2002, 2007 and 2012. New Zealand Medical Journal, 129(1428), 9-15. Retrieved from https://www.nzma.org.nz/journal

de Hoog, V. C., Lim, S. H., Bank, I. E. M., Gijsberts, C. M., Ibrahim, I. B., Kuan, W. S., … Richards, A. M., … Timmers, L. (2016). Ethnic differences in clinical outcome of patients presenting to the emergency department with chest pain. European Heart Journal, 5(7), 32-40. doi: 10.1177/2048872615623064

Chan, M. M. Y., Santhanakrishnan, R., Chong, J. P. C., Chen, Z., Tai, B. C., Liew, O. W., … Richards, A. M., & Lam, C. S. P. (2016). Growth differentiation factor 15 in heart failure with preserved vs. reduced ejection fraction. European Journal of Heart Failure, 18(1), 81-88. doi: 10.1002/ejhf.431

Zhou, Y., Chen, Q., Lew, K. S., Richards, A. M., & Wang, P. (2016). Discovery of potential therapeutic miRNA targets in cardiac ischemia-reperfusion injury. Journal of Cardiovascular Pharmacology & Therapeutics, 21(3), 296-309. doi: 10.1177/1074248415604463

Ellmers, L. J., Rademaker, M. T., Charles, C. J., Yandle, T. G., & Richards, A. M. (2016). (PRO)renin receptor blockade ameliorates cardiac injury and remodeling and improves function after myocardial infarction. Journal of Cardiac Failure, 22(1), 64-72. doi: 10.1016/j.cardfail.2015.08.341

Journal - Research Other

Richards, A. M. (2016). The relationship of plasma NT-proBNP to age and outcomes in heart failure. JACC: Heart Failure, 4(9), 746-748. doi: 10.1016/j.jchf.2016.06.006

Richards, M. (2016). No smoke without fire? European Journal of Heart Failure, 18(6), 638-640. doi: 10.1002/ejhf.560

Koh, K. W. L., Wang, W., Richards, A. M., Chan, M. Y., & Cheng, K. K. F. (2016). Effectiveness of advanced practice nurse-led telehealth on readmissions and health-related outcomes among patients with post-acute myocardial infarction: ALTRA Study Protocol. Journal of Advanced Nursing. doi: 10.1111/jan.12933

Bayes-Genis, A., Prickett, T. C., Richards, A. M., Barallat, J., & Lupón, J. (2016). Soluble neprilysin retains catalytic activity in heart failure. Journal of Heart & Lung Transplantation, 35(5), 684-685. doi: 10.1016/j.healun.2015.12.015

Conference Contribution - Published proceedings: Abstract

Ng, G., Boey, E., Frampton, C., Richards, M., Yeo, T. C., & Lee, C.-H. (2016). Obstructive sleep apnea is associated with visit-to-visit variability in low density lipoprotein-cholesterol in patients with coronary artery disease. JACC, 67(13, Suppl.), (pp. 2138). doi: 10.1016/S0735-1097(16)32139-8

Conference Contribution - Poster Presentation (not in published proceedings)

Lewis, L. K., Raudsepp, S. D., Yandle, T. G., & Richards, A. M. (2016, August). Development of a specific immunoassay to measure BNP1-32 in plasma without the confounding influences of precursor peptides and peptide metabolites: Could this improve heart failure diagnosis? Poster session presented at the Medical Sciences Congress (MedSci), Nelson, New Zealand.

Intellectual Property

Pemberton, C. J., Richards, A. M., Charles, C. J., & Siriwardena, M. (2016). Cardiovascular therapeutics. [Marker reference: BNPTx] (2012 8 0050843.1). China.

Other Research Output

Richards, M. (2016, March).The importance of having a good-humoured heart. University of Otago, Christchurch, New Zealand. [Public Seminar].

2015

Journal - Research Article

The EchoNoRMAL (Echocardiographic Normal Ranges Meta-Analysis of the Left Heart) Collaboration, including Whalley, G. A., Cameron, V., Richards, A. M., & Troughton, R. (2015). Ethnic-specific normative reference values for echocardiographic LA and LV size, LV mass, and systolic function: The EchoNoRMAL Study. JACC: Cardiovascular Imaging, 8(6), 656-665. doi: 10.1016/j.jcmg.2015.02.014

Lee, J., Than, M., Aldous, S., Troughton, R., Richards, M., & Pemberton, C. J. (2015). CNP signal peptide in patients with cardiovascular disease. Frontiers in Cardiovascular Medicine, 2, 28. doi: 10.3389/fcvm.2015.00028

Lim, S. L., Gao, Q., Nyunt, M. S. Z., Gong, L., Lunaria, J. B., Lim, M. L., … Richards, A. M., … Ng, T. P. (2015). Vascular health indices and cognitive domain function: Singapore longitudinal ageing studies. Journal of Alzheimer's Disease, 50(1), 27-40. doi: 10.3233/jad-150516

Aldous, S., Richards, A. M., Cullen, L., Pickering, J. W., & Than, M. (2015). The incremental value of stress testing in patients with acute chest pain beyond serial cardiac troponin testing. Emergency Medicine Journal, 33(5), 319-324. doi: 10.1136/emermed-2015-204823

Liebetrau, C., Gaede, L., Dörr, O., Blumenstein, J., Rosenburg, S., Hoffmann, J., … Richards, A. M., & Pemberton, C. J. (2015). Reference values and release kinetics of B-type natriuretic peptide signal peptide in patients with acute myocardial infarction. Clinical Chemistry, 61(12), 1532-1539. doi: 10.1373/clinchem.2015.244327

Brunner-La Rocca, H.-P., Eurlings, L., Richards, A. M., Januzzi, J. L., Pfisterer, M. E., Dahlström, U., … Frampton, C. M., Nicholls, M. G., & Troughton, R. W. (2015). Which heart failure patients profit from natriuretic peptide guided therapy? A meta-analysis from individual patient data of randomized trials. European Journal of Heart Failure, 17(12), 1252-1261. doi: 10.1002/ejhf.401

Simpson, J., Castagno, D., Doughty, R. N., Poppe, K. K., Earle, N., Squire, I., Richards, M., … Whalley, G. A., … on behalf of the Meta-Analysis Global Group in Chronic Heart Failure (MAGGIC). (2015). Is heart rate a risk marker in patients with chronic heart failure and concomitant atrial fibrillation? Results from the MAGGIC meta-analysis. European Journal of Heart Failure, 17(11), 1182-1191. doi: 10.1002/ejhf.346

Richards, A. M. (2015). Biomarkers for heart failure in Asia. Heart Failure Clinics, 11, 551-561. doi: 10.1016/j.hfc.2015.07.007

Vodovar, N., Séronde, M.-F., Laribi, S., Gayat, E., Lassus, J., Januzzi, Jr, J. L., … Richards, A. M., … on behalf of the GREAT Network. (2015). Elevated plasma B-type natriuretic peptide concentrations directly inhibit circulating neprilysin activity in heart failure. JACC: Heart Failure, 3(8), 629-636. doi: 10.1016/j.jchf.2015.03.011

Lilyanna, S., Peh, M. T., Liew, O. W., Wang, P., Moore, P. K., Richards, A. M., & Martinez, E. C. (2015). GYY4137 attenuates remodeling, preserves cardiac function and modulates the natriuretic peptide response to ischemia. Journal of Molecular & Cellular Cardiology, 87, 27-37. doi: 10.1016/j.yjmcc.2015.07.028

Pickering, J. W., Young, J. M., George, P., Aldous, S., Cullen, L., Greenslade, J. H., Richards, A. M., Troughton, R., Ardagh, M., Frampton, C. M., & Than, M. P. (2015). The utility of presentation and 4-hour high sensitivity troponin I to rule-out acute myocardial infarction in the emergency department. Clinical Biochemistry, 48(18), 1219-1224. doi: 10.1016/j.clinbiochem.2015.07.033

Chan, W. Y. W., Charles, C. J., Frampton, C. M., Richards, A. M., Crozier, I. G., Troughton, R. W., & Jardine, D. L. (2015). Human muscle sympathetic nerve responses to urocortin-2 in health and stable heart failure. Clinical & Experimental Pharmacology & Physiology, 42(9), 888-895. doi: 10.1111/1440-1681.12449

Yandle, T. G., & Richards, A. M. (2015). B-Type natriuretic peptide circulating forms: Analytical and bioactivity issues [Invited critical review]. Clinica Chimica Acta, 448, 195-205. doi: 10.1016/j.cca.2015.07.004

Rademaker, M. T., Ellmers, L. J., Charles, C. J., & Richards, A. M. (2015). Urocortin 2 protects heart and kidney structure and function in an ovine model of acute decompensated heart failure: Comparison with dobutamine. International Journal of Cardiology, 197, 56-65. doi: 10.1016/j.ijcard.2015.06.011

Ellmers, L. J., Scott, N. J. A., Cameron, V. A., Richards, A. M., & Rademaker, M. T. (2015). Chronic urocortin 2 administration improves after cardiac function and ameliorates cardiac remodeling after experimental myocardial infarction. Journal of Cardiovascular Pharmacology, 65(3), 269-275. doi: 10.1097/FJC.0000000000000190

Jackson, C. E., Castagno, D., Maggioni, A. P., Køber, L., Squire, I. B., Swedberg, K., … Richards, A. M., … Whalley, G., … on behalf of the Meta-Analysis Global Group in Chronic Heart Failure (MAGGIC). (2015). Differing prognostic value of pulse pressure in patients with heart failure with reduced or preserved ejection fraction: Results from the MAGGIC individual patient meta-analysis. European Heart Journal, 36(18), 1106-1114. doi: 10.1093/eurheartj/ehu490

Lee, J., Young, J., Frampton, C. M., Aldous, S., Troughton, R. W., Than, M., Richards, A. M., & Pemberton, C. J. (2015). A novel troponin T peptide in humans: Assay, biochemistry and preliminary findings in acute coronary syndromes. International Journal of Cardiology, 190, 68-74. doi: 10.1016/j.ijcard.2015.04.145

Aldous, S., Elliott, J., McClean, D., Puri, A., & Richards, A. M. (2015). Outcomes in patients presenting with symptoms suggestive of acute coronary syndrome with elevated cardiac troponin but non-obstructive coronary disease on angiography. Heart, Lung & Circulation, 24(9), 869-878. doi: 10.1016/j.hlc.2015.02.019

Maisel, A. S., Richards, A. M., Pascual-Figal, D., & Mueller, C. (2015). Serial ST2 testing in hospitalized patients with acute heart failure. American Journal of Cardiology, 115(7, Suppl.), 32B-37B. doi: 10.1016/j.amjcard.2015.01.038

Wong, L. L., Wee, A. S. Y., Lim, J. Y., Ng, J. Y. X., Chong, J. P. C., Liew, O. W., … Richards, A. M., & Chen, Y.-T. (2015). Natriuretic peptide receptor 3 (NPR3) is regulated by microRNA-100. Journal of Molecular & Cellular Cardiology, 82, 13-21. doi: 10.1016/j.yjmcc.2015.02.019

Meller, B., Cullen, L., Parsonage, W. A., Greenslade, J. H., Aldous, S., Reichlin, T., … Troughton, R., Pemberton, C. J., Richards, A. M., … Than, M., & Mueller, C. (2015). Accelerated diagnostic protocol using high-sensitivity cardiac troponin T in acute chest pain patients. International Journal of Cardiology, 184C, 208-215. doi: 10.1016/j.ijcard.2015.02.006

Richards, A. M., Di Somma, S., & Mueller, T. (2015). ST2 in stable and unstable ischemic heart diseases. American Journal of Cardiology, 115(7 (Suppl.)), 48B-58B. doi: 10.1016/j.amjcard.2015.01.041

Bayes-Genis, A., Richards, A. M., Maisel, A. S., Mueller, C., & Ky, B. (2015). Multimarker testing with ST2 in chronic heart failure. American Journal of Cardiology, 115(7 (Suppl.)), 76B-80B. doi: 10.1016/j.amjcard.2015.01.045

Wong, L. L., Armugam, A., Sepramaniam, S., Karolina, D. S., Lim, K. Y., Lim, J. Y., … Richards, A. M. (2015). Circulating microRNAs in heart failure with reduced and preserved left ventricular ejection fraction. European Journal of Heart Failure, 17, 393-404. doi: 10.1002/ejhf.223

Siriwardena, M., Pilbrow, A., Frampton, C., MacDonald, S. M., Wilkins, G. T., & Richards, A. M. (2015). Complications of intra-aortic balloon pump use: Does the final position of the IABP tip matter? Anaesthesia & Intensive Care, 43(1), 66-73.

Whalley, G. A., Pitama, S., Troughton, R. W., Doughty, R. N., Gamble, G. D., Gillies, T., Wells, J. E., Faatoese, A., Huria, T., Richards, M., & Cameron, V. A. (2015). Higher prevalence of left ventricular hypertrophy in two Māori cohorts: Findings from the Hauora Manawa/Community Heart Study. Australian & New Zealand Journal of Public Health, 39(1), 26-31. doi: 10.1111/1753-6405.12300

Earle, N. J., Poppe, K. K., Pilbrow, A. P., Cameron, V. A., Troughton, R. W., Skinner, J. R., … Whalley, G. A., … Richards, A. M., & Doughty, R. N. (2015). Genetic markers of repolarization and arrhythmic events following acute coronary syndromes. American Heart Journal, 169(4), 579-586.e3. doi: 10.1016/j.ahj.2014.11.015

Journal - Research Other

Richards, A. M. (2015). Plasma neprilysin concentrations: A new prognostic marker in heart failure? Revista Española de Cardiología: English Edition, 68(12), 1053-1055. doi: 10.1016/j.rec.2015.09.004

Richards, A. M., & Frampton, C. M. (2015). Can circulating biomarkers identify heart failure patients at low risk? European Journal of Heart Failure, 17(12), 1213-1215. doi: 10.1002/ejhf.438

Chen, Y.-T., Liew, O.-W., & Richards, A. M. (2015). MicroRNA expression profiles of human left ventricle derived cardiac cells in normoxic and hypoxic conditions [Data in brief]. Genomics Data, 5, 59-60. doi: 10.1016/j.gdata.2015.05.020

Chang, I. C. Y., Chen, L. Y., Chong, J. P. C., Austin, E., Quay, C. N., Gong, L., Richards, A. M., & Ling, L. H. (2015). Plasma mid-regional pro-atrial natriuretic peptide and N-terminal pro-brain natriuretic peptide improve discrimination of lone atrial fibrillation. International Journal of Cardiology, 188, 10-12. doi: 10.1016/j.ijcard.2015.03.415

Conference Contribution - Published proceedings: Abstract

Fitzsimons, S., Troughton, R., Gamble, G. D., Devlin, G. D., Lund, M., Richards, M., & Doughty, R. N. (2015). High prevalence of iron deficiency in heart failure with preserved ejection fraction. European Heart Journal, 36(Suppl. 1), (pp. 876-877). doi: 10.1093/eurheartj/ehv401

Pemberton, C. J., Lee, J., Than, M., Pickering, J. W., Troughton, R. W., & Richards, M. (2015). Can copeptin assist the diagnosis of acute kidney injury in breathless patients? European Heart Journal, 36(Suppl. 1), (pp. 800). doi: 10.1093/eurheartj/ehv400

Pickering, J. W., Young, J. M., George, P., Wallace, J., Aldous, S., Troughton, R., Richards, A. M., & Martin, M. P. (2015). An updated heart fatty acid binding protein assay facilitates improved rule-out of acute myocardial infarction within 2 hours of entry to the emergency department: Threshold derivation and validation. European Heart Journal, 36(Suppl. 1), (pp. 591). doi: 10.1093/eurheartj/ehv400

Liebetrau, C., Doerr, O. D., Gaede, L. G., Berkowitsch, A. B., Troidl, C. T., Hamm, C. H., … Richards, A. M., & Pemberton, C. J. (2015). Release kinetics of B-type natriuretic peptide signal peptide (BNPsp) in patients with acute myocardial infarction. European Heart Journal, 36(Suppl. 1), (pp. 71). doi: 10.1093/eurheartj/ehv398

Pickering, J. W., Young, J. M., George, P., Aldous, S., Troughton, R., Richards, A. M., … Than, M. (2015). The 99th percentile of an updated heart Fatty Acid Binding Protein assay combines with high sensitive Troponin l to rule out acute myocardial infarction on presentation to the emergency department. European Heart Journal, 36(Suppl. 1), (pp. 4). doi: 10.1093/eurheartj/ehv398

Wheeler, N. E., Cameron, V. A., Pearson, J. F., Gardener, P. T., Moravec, C. S., Sweet, W. E., … Troughton, R. W., Richards, A. M., & Pilbrow, A. P. (2015). Expression quantitative trait locus (eQTL) map for genetic variants associated with cardiovascular traits in human heart. Circulation, 132, A17027. [Abstract]

Fitzsimons, S., Troughton, R., Gamble, G., Pemberton, C., Devlin, G., Lund, M., Richards, M., & Doughty, R. (2015). High prevalence of iron deficiency in heart failure with preserved ejection fraction. Heart, Lung & Circulation, 24(Suppl. 2), (pp. S78). doi: 10.1016/j.hlc.2015.04.070

Arshad, M., Richards, M., Pemberton, C., & Troughton, R. (2015). Routine measurement of NT-proBNP and post-discharge clinical outcomes: Initial findings from a randomised controlled trial. Heart, Lung & Circulation, 24(Suppl. 2), (pp. S94). doi: 10.1016/j.hlc.2015.04.109

Doughty, R., Espiner, E., Prickett, T., Troughton, R., Frampton, C., Whalley, G., … Richards, M. (2015). C type natriuretic peptide (CNP) in acute coronary syndrome (ACS): Prognostic value and relation to cardiac and renal function at baseline. Heart, Lung & Circulation, 24(Suppl. 2), (pp. S83). doi: 10.1016/j.hlc.2015.04.083

Conference Contribution - Verbal presentation and other Conference outputs

Wheeler, N. E., Cameron, V. A., Pearson, J. F., Gardner, P. P., Moravec, C. S., Sweet, W. E., … Troughton, R. W., Richards, A. M., & Pilbrow, A. P. (2015, August-September). An expression quantitative trait locus (eQTL) map for human heart. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2014

Journal - Research Article

Lever, M., George, P. M., Slow, S., Bellamy, D., Young, J. M., Ho, M., … Elmslie, J. L., … Troughton, R. W., Frampton, C. M., Richards, A. M., & Chambers, S. T. (2014). Betaine and trimethylamine-N-oxide as predictors of cardiovascular outcomes show different patterns in diabetes mellitus: An observational study. PLoS ONE, 9(12), e114969. doi: 10.1371/journal.pone.0114969

Aldous, S., Richards, A. M., George, P. M., Cullen, L., Parsonage, W. A., Flaws, D., Florkowski, C. M., Troughton, R. W., … Than, M. (2014). Comparison of new point-of-care troponin assay with high sensitivity troponin in diagnosing myocardial infarction. International Journal of Cardiology, 177(1), 182-186. doi: 10.1016/j.ijcard.2014.09.026

Vodovar, N., Séronde, M.-F., Laribi, S., Gayat, E., Lassus, J., Boukef, R., … Richards, A. M., … on behalf of the GREAT Network. (2014). Post-translational modifications enhance NT-proBNP and BNP production in acute decompensated heart failure. European Heart Journal, 35, 3434-3441. doi: 10.1093/eurheartj/ehu314

Pilbrow, A. P., Cordeddu, L., Cameron, V. A., Frampton, C. M., Troughton, R. W., Doughty, R. N., Whalley, G. A., … Yandle, T. G., Richards, A. M., & Foo, R. S.-Y. (2014). Circulating miR-323-3p and miR-652: Candidate markers for the presence and progression of acute coronary syndromes. International Journal of Cardiology, 176, 375-385. doi: 10.1016/j.ijcard.2014.07.068

Nedoboy, P., Morgan, P. E., Mocatta, T. J., Richards, A. M., Winterbourn, C. C., & Davies, M. J. (2014). High plasma thiocyanate levels are associated with enhanced myeloperoxidase-induced thiol oxidation and long-term survival in subjects following a first myocardial infarction. Free Radical Research, 48(10), 1256-1266. doi: 10.3109/10715762.2014.947286

Than, M., Aldous, S., Lord, S. J., Goodacre, S., Frampton, C. M. A., Troughton, R., George, P., Florkowski, C. M., Ardagh, M., Smyth, D., Jardine, D. L., … Young, J., Hamilton, G., Deely, J. M., … Richards, A. M. (2014). A 2-hour diagnostic protocol for possible cardiac chest pain in the emergency department: A randomized clinical trial. JAMA Internal Medicine, 174(1), 51-58. doi: 10.1001/jamainternmed.2013.11362

de Carvalho, L. P., Gao, F., Chen, Q., Hartman, M., Sim, L.-L., Koh, T.-H., … Richards, A. M., … Chan, M. Y. (2014). Differences in late cardiovascular mortality following acute myocardial infarction in three major Asian ethnic groups. European Heart Journal, 3(4), 354-362. doi: 10.1177/2048872614527007

Tan, A., Hau, W., Ho, H.-H., Maralani, H. G., Loo, G., Khoo, S.-M., … Richards, A. M., … Lee, C.-H. (2014). OSA and coronary plaque characteristics. Chest, 145(2), 322-330. doi: 10.1378/chest.13-1163

Liew, O. W., Ang, C. X., Peh, Y. P., Chong, P. C. J., Ng, Y. X., Hwang, L.-A., … Richards, A. M. (2014). A His₆-SUMO-eXact tag for producing human prepro-Urocortin 2 in Escherichia coli for raising monoclonal antibodies. Journal of Immunological Methods, 403(1-2), 37-51. doi: 10.1016/j.jim.2013.11.015

Prickett, T. C. R., Wellby, M., Barrell, G. K., Richards, A. M., & Espiner, E. A. (2014). Differential response of C-type natriuretic peptide to estrogen and dexamethasone in adult bone. Steroids, 87, 1-5. doi: 10.1016/j.steroids.2014.05.007

Rademaker, M. T., Charles, C. J., & Richards, M. (2014). Sheep for the study of the urocortins and other hormones. Cardiovascular Endocrinology, 3(1), 39-43. doi: 10.1097/XCE.0000000000000024

Richards, A. M., Januzzi, Jr, J. L., & Troughton, R. W. (2014). Natriuretic peptides in heart failure with preserved ejection fraction. Heart Failure Clinics, 10(3), 453-470. doi: 10.1016/j.hfc.2014.04.006

Pemberton, C. J., Siriwardena, M., Kleffmann, T., & Richards, A. M. (2014). C-type natriuretic peptide (CNP) signal peptide fragments are present in the human circulation. Biochemical & Biophysical Research Communications, 449, 301-306. doi: 10.1016/j.bbrc.2014.05.020

Charles, C. J., Jardine, D. L., Rademaker, M. T., & Richards, A. M. (2014). Low-dose B-type natriuretic peptide raises cardiac sympathetic nerve activity in sheep. American Journal of Physiology: Regulatory, Integrative & Comparative Physiology, 307(2), R206-R211. doi: 10.1152/ajpregu.00404.2013

Troughton, R. W., Frampton, C. M., Brunner-La Rocca, H.-P., Pfisterer, M., Eurlings, L. W. M., Erntell, H., … Richards, A. M., … Nicholls, M. G. (2014). Effect of B-type natriuretic peptide-guided treatment of chronic heart failure on total mortality and hospitalization: An individual patient meta-analysis. European Heart Journal, 35, 1559-1567. doi: 10.1093/eurheartj/ehu090

Palmer, B. R., Slow, S., Ellis, K. L., Pilbrow, A. P., Skelton, L., Frampton, C. M., Palmer, S. C., Troughton, R. W., Yandle, T. G., … Whalley, G. A., … Lever, M., George, P. M., Chambers, S. T., … Richards, A. M., & Cameron, V. A. (2014). Genetic polymorphism rs6922269 in the MTHFD1L gene is associated with survival and baseline active vitamin B12 levels in post-acute coronary syndromes patients. PLoS ONE, 9(3), e89029. doi: 10.1371/journal.pone.0089029

Mahagamasekera, P. G., Ruygrok, P. N., Palmer, S. C., Richards, A. M., Ansell, G. S., Nicholls, M. G., Pemberton, C. J., Lewis, L. K., & Yandle, T. G. (2014). B-type natriuretic peptide forms within the heart, coronary sinus, and peripheral circulation in humans: Evidence for degradation before secretion. Clinical Chemistry, 60(3), 549-558. doi: 10.1373/clinchem.2013.210435

Cullen, L., Aldous, S., Than, M., Greenslade, J. H., Tate, J. R., George, P. M., … Richards, A. M., Ungerer, J. P. J., Troughton, R. W., … Pemberton, C. J., Florkowski, C., … Parsonage, W. A. (2014). Comparison of high sensitivity troponin T and I assays in the diagnosis of non-ST elevation acute myocardial infarction in emergency patients with chest pain. Clinical Biochemistry, 47(6), 321-326. doi: 10.1016/j.clinbiochem.2013.11.019

Conference Contribution - Published proceedings: Abstract

Wong, L. L., Lew, K. S., Chen, Q., Rademaker, M. T., Ellmers, L. J., Charles, C. J., Richards, A. M., & Wang, P. (2014). Identification of microRNA in an ovine model of heart failure. Circulation, 130(Suppl. 2), A16470. [Abstract]

Charles, C. J., Jardine, D. L., Rademaker, M. T., & Richards, A. M. (2014). Systemic angiotensin II does not increase cardiac sympathetic nerve activity in conscious sheep. Endocrine Reviews, 35(3, Suppl.), MON-0865. Retrieved from http://press.endocrine.org/series/endo-meetings

Pilbrow, A. P., Frampton, C. M., Richards, A. M., Troughton, R. W., & Cameron, V. A. (2014). Elevated levels of circulating microRNA-223, microRNA-127 and microRNA-146a are associated with risk of near future cardiovascular events in asymptomatic individuals. Circulation, 130(Suppl. 2), A18066. [Abstract]

Pilbrow, A. P., Frampton, C. M., Richards, A. M., Troughton, R. W., & Cameron, V. A. (2014). Amino-terminal pro-brain natriuretic peptide improves risk stratification in asymptomatic individuals at very high risk of future cardiovascular events. Circulation, 130(Suppl. 2), A19648. [Abstract]

Cameron, V. A., Pilbrow, A. P., Ellis, K. L., Palmer, B. R., Troughton, R. W., & Richards, A. M. (2014). Duelling hormones: The renin-aldosterone system versus the natriuretic peptides in heart disease. Proceedings of the Medical Sciences Congress (MedSci). (pp. 15). Retrieved from http://www.physoc.org.nz/meetings/archive/medsci-2014-abstracts

Earle, N., Poppe, K., Cameron, V., Pilbrow, A., Troughton, R., Skinner, J., … Richards, M., & Doughty, R. (2014). Risk of sudden cardiac death following acute coronary syndromes: Interplay of single nucleotide polymorphisms and the presence of heart failure. Heart, Lung & Circulation, 23(Suppl. 2), (pp. e9). doi: 10.1016/j.hlc.2014.07.023

Ellis, C., Gamble, G., Devlin, G., Elliott, J., Hamer, A., Matsis, P., Williams, M., Troughton, R., Mann, S., … Richards, A., … for the NZ Regional Cardiac Society ACS Audit Group, and the CSANZ 'SNAPSHOT' ACS Audit Group. (2014). Improved rates of secondary prevention medication following hospitalisation for an acute coronary syndrome (ACS) in New Zealand (NZ) : Results from the NZ ACS national audits of 2002, 2007 and 2012. Heart, Lung & Circulation, 23(Suppl. 1), (pp. e23-e24). doi: 10.1016/j.hlc.2014.04.187

Elliott, J., Williams, M., Matsis, P., Gamble, G., Troughton, R., Hamer, A., … Mann, S., Richards, A., … for the NZ Regional Cardiac Society ACS Audit Group, and the CSANZ 'SNAPSHOT' ACS Audit Group. (2014). A decade of improvement in investigations received and treatments delivered to New Zealand (NZ) ST-elevation myocardial infarction (STEMI): Results from the NZACS national audits of 2002, 2007 and 2012. Heart, Lung & Circulation, 23(Suppl. 1), (pp. e22-e23). doi: 10.1016/j.hlc.2014.04.185

Devlin, G., Hamer, A., Troughton, R., Gamble, G., Matsis, P., Williams, M., Elliott, J., Mann, S., Richards, A., … for the NZ Regional Cardiac Society ACS Audit Group, and the CSANZ 'SNAPSHOT' ACS Audit Group. (2014). Management of non ST-elevation acute coronary syndrome (NSTEACS) patients in New Zealand (NZ): A longitudinal analysis: Results from the NZACS national audits of 2002, 2007 and 2012. Heart, Lung & Circulation, 23(Suppl. 1), (pp. e8-e9). doi: 10.1016/j.hlc.2014.04.148

Conference Contribution - Verbal presentation and other Conference outputs

Richards, M. (2014, November). Peptides in practice: B type cardiac natriuretic peptides in the management of heart failure. Verbal presentation at the HeartOtago First Australasian Symposium: Bench to Bedside and Back: New Advances in Cardiovascular Research, Dunedin, New Zealand.

2013

Chapter in Book - Research

Richards, M., & Rademaker, M. (2013). Urocortins. In A. Kastin (Ed.), Handbook of biologically active peptides. (2nd ed.) (pp. 1428-1436). San Diego, CA: Academic Press. doi: 10.1016/B978-0-12-385095-9.00194-9

Chapter in Book - Other

Richards, M., Troughton, R., Espiner, E., Cameron, V., Ellmers, L., Pilbrow, A., Charles, C., Rademaker, M., Pemberton, C., & Yandle, T. (2013). Christchurch Heart Institute. In P. Joyce, G. Nicholls, K. Thomas & T. Wilkinson (Eds.), The Christchurch experience: 40 years of research and teaching. (pp. 68-74). Christchurch, New Zealand: University of Otago.

Journal - Research Article

The Echocardiographic Normal Ranges Meta-Analysis of the Left Heart (EchoNoRMAL) Collaboration, including Whalley, G. A., Cameron, V., Richards, A. M., & Troughton, R. (2013). A meta-analysis of echocardiographic measurements of the left heart for the development of normative reference ranges in a large international cohort: The EchoNoRMAL study. European Heart Journal, 15, 341-348. doi: 10.1093/ehjci/jet240

Möckel, M., Searle, J., Hartmann, O., Anker, S. D., Peacock, W. F., Wu, A. H. B., … on behalf of the BACH Writing group, including Richards, M. (2013). Mid-regional pro-adrenomedullin improves disposition strategies for patients with acute dyspnoea: Results from the BACH trial. Emergency Medicine Journal, 30(8), 633-637. doi: 10.1136/emermed-2012-201530

Kong, C. H., Lin, X. Y., Woo, C. C., Wong, H. C., Lee, C. N., Richards, A. M., & Sorokin, V. A. (2013). Characteristics of aortic wall extracellular matrix in patients with acute myocardial infarction: Tissue microarray detection of collagen I, collagen III and elastin levels. Interactive Cardiovascular & Thoracic Surgery, 16(1), 11-15. doi: 10.1093/icvts/ivs421

Hein, T., Loo, G., Ng, W.-Y., Tai, B.-C., Kajiya, T., Tan, A., … Richards, M., & Lee, C.-H. (2013). Relationship between apnoea-hypopnoea index and angiographic 
coronary disease phenotypes in patients presenting with acute 
myocardial infarction. Acute Cardiac Care, 15(2), 26-33. doi: 10.3109/17482941.2012.741249

de Carvalho, L. P., McCullough, P. A., Gao, F., Sim, L. L., Tan, H. C., Foo, D., … Richards, A. M., … Yeo, T.-C. (2013). Renal function and anaemia in acute myocardial infarction. International Journal of Cardiology, 168(2), 1397-1401. doi: 10.1016/j.ijcard.2012.12.017

Kajiya, T., Agahari, F., Wai, K. L., Tai, B.-C., Lee, C.-H., Chan, K.-H., … Richards, A. M., … Chan, M. Y. (2013). A single-center experience of transitioning from a routine transfemoral to a transradial intervention approach in ST-elevation myocardial infarction: Impact on door-to-balloon time and clinical outcomes. Journal of Cardiology, 62(1), 12-17. doi: 10.1016/j.jjcc.2013.02.008

Low, T.-T., Hong, W.-Z., Tai, B.-C., Hein, T., Khoo, S.-M., Tan, A. Y., … Richards, M., & Lee, C.-H. (2013). The influence of timing of polysomnography on diagnosis of obstructive sleep apnea in patients presenting with acute myocardial infarction and stable coronary artery disease. Sleep Medicine, 14(10), 985-990. doi: 10.1016/j.sleep.2013.03.025

Nagarajan, V., Gopalan, V., Kaneko, M., Angeli, V., Gluckman, P., Richards, A. M., … Velan, S. S. (2013). Cardiac function and lipid distribution in rats fed a high-fat diet: In vivo magnetic resonance imaging and spectroscopy. American Journal of Physiology: Heart & Circulatory Physiology, 304, H1495-H1504. doi: 10.1152/ajpheart.00478.2012

Hein, T., Loo, G., Tai, B.-C., Phua, Q.-H., Chan, M. Y., Poh, K.-K., … Richards, M., & Lee, C.-H. (2013). Myocardial infarction in Singapore: Ethnic variation in evidence-based therapy and its association with socioeconomic status, social network size and perceived stress level. Heart, Lung & Circulation, 22, 1011-1017. doi: 10.1016/j.hlc.2013.04.119

Lee, C.-H., Ng, W.-Y., Hau, W., Ho, H.-H., Tai, B.-C., Chan, M. Y., Richards, A. M., & Tan, H.-C. (2013). Excessive daytime sleepiness is associated with longer culprit lesion and adverse outcomes in patients with coronary artery disease. Journal of Clinical Sleep Medicine, 9(12), 1267-1272. doi: 10.5664/jcsm.3266

Tan, H. T., Ling, L. H., Dolor-Torres, M. C., Yip, J. W.-L., Richards, A. M., & Chung, M. C. M. (2013). Proteomics discovery of biomarkers for mitral regurgitation caused by mitral valve prolapse. Journal of Proteomics, 94, 337-345. doi: 10.1016/j.jprot.2013.10.009

Lam, C. S. P., Anand, I., Zhang, S., Shimizu, W., Narasimhan, C., Park, S. W., … Richards, A. M. (2013). Asian sudden cardiac death in heart failure (ASIAN-HF) registry. European Journal of Heart Failure, 15(8), 928-936. doi: 10.1093/eurjhf/hft045

Dunkler, D., Dehghan, M., Teo, K. K., Heinze, G., Gao, P., Kohl, M., … for the ONTARGET Investigators, including Richards, A. M. (2013). Diet and kidney disease in high-risk individuals with type 2 diabetes mellitus. JAMA Internal Medicine, 173(18), 1682-1692. doi: 10.1001/jamainternmed.2013.9051

Chan, W. Y. W., Frampton, C. M., Crozier, I. G., Troughton, R. W., & Richards, A. M. (2013). Urocortin-2 infusion in acute decompensated heart failure: Findings from the UNICORN Study. JACC: Heart Failure, 1(5), 433-441. doi: 10.1016/j.jchf.2013.07.003

Stamp, L. K., Wells, J. E., Pitama, S., Faatoese, A., Doughty, R. N., Whalley, G., Richards, A. M., & Cameron, V. A. (2013). Hyperuricaemia and gout in New Zealand rural and urban Māori and non-Māori communities. Internal Medicine Journal, 43(6), 678-684. doi: 10.1111/imj.12062

Rademaker, M. T., Charles, C. J., Nicholls, M. G., & Richards, A. M. (2013). Interactions of enhanced urocortin 2 and mineralocorticoid receptor antagonism in experimental heart failure. Circulation: Heart Failure, 6(4), 825-832. doi: 10.1161/circheartfailure.112.000205

Richards, M., Di Somma, S., Mueller, C., Nowak, R., Peacock, W. F., Ponikowski, P., … Maisel, A. (2013). Atrial fibrillation impairs the diagnostic performance of cardiac natriuretic peptides in dyspneic patients: Results from the BACH Study (Biomarkers in ACute Heart Failure). JACC: Heart Failure, 1(3), 192-199. doi: 10.1016/j.jchf.2013.02.004

Schluter, P. J., Spittlehouse, J. K., Cameron, V. A., Chambers, S., Gearry, R., Jamieson, H. A., Kennedy, M., Lacey, C. J., Murdoch, D. R., Pearson, J., Porter, R. J., Richards, M., Skidmore, P. M. L., Troughton, R., Vierck, E., & Joyce, P. R. (2013). Canterbury Health, Ageing and Life Course (CHALICE) study: Rationale, design and methodology. New Zealand Medical Journal, 126(1375). Retrieved from http://www.nzma.org.nz/journal

Greenslade, J. H., Cullen, L., Than, M., Aldous, S., Chu, K., Brown, A. F. T., Richards, A. M., Pemberton, C. J., George, P., & Parsonage, W. A. (2013). Validation of the Vancouver Chest Pain Rule using troponin as the only biomarker: A prospective cohort study. American Journal of Emergency Medicine, 31(7), 1103-1107. doi: 10.1016/j.ajem.2013.04.016

Ellis, K. L., Cameron, V. A., Troughton, R. W., Frampton, C. M., Ellmers, L. J., & Richards, A. M. (2013). Circulating microRNAs as candidate markers to distinguish heart failure in breathless patients. European Journal of Heart Failure, 15(10), 1138-1147. doi: 10.1093/eurjhf/hft078

Cullen, L., Mueller, C., Parsonage, W. A., Wildi, K., Greenslade, J. H., Twerenbold, R., Aldous, S., … Troughton, R., … George, P., … Pemberton, C. J., Richards, A. M., … Florkowski, C., Deely, J. M., & Than, M. (2013). Validation of high-sensitivity troponin I in a 2-hour diagnostic strategy to assess 30-day outcomes in emergency department patients with possible acute coronary syndrome. JACC, 62(14), 1242-1249. doi: 10.1016/j.jacc.2013.02.078

Greenslade, J. H., Cullen, L., Kalinowski, L., Parsonage, W., Palmer, S., Aldous, S., Richards, M., … Troughton, R., Pemberton, C., & Than, M. (2013). Examining renal impairment as a risk factor for acute coronary syndrome: A prospective observational study. Annals of Emergency Medicine, 62(1), 38-46. doi: 10.1016/j.annemergmed.2013.01.011

Santhanakrishnan, R., Ng, T. P., Cameron, V. A., Gamble, G. D., Ling, L. H., Sim, D., … Troughton, R., Richards, A. M., … Lam, C. S. P. (2013). The Singapore Heart Failure Outcomes and Phenotypes (SHOP) study and Prospective Evaluation of Outcome in Patients with Heart Failure with Preserved Left Ventricular Ejection Fraction (PEOPLE) study: Rationale and design. Journal of Cardiac Failure, 19(3), 156-162. doi: 10.1016/j.cardfail.2013.01.007

Chan, K., Patel, R. S., Newcombe, P., Nelson, C. P., Qasim, A., Epstein, S. E., … Ellis, K. L., … Richards, A. M., Cameron, V. A., … Ye, S. (2013). Association between the chromosome 9p21 locus and angiographic coronary artery disease burden: A collaborative meta-analysis. JACC, 61(9), 957-970. doi: 10.1016/j.jacc.2012.10.051

Gaggin, H. K., Truong, Q. A., Rehman, S. U., Mohammed, A. A., Bhardwaj, A., Parks, K. A., … Richards, A. M., Troughton, R. W., Lainchbury, J. G., … Januzzi, Jr, J. L. (2013). Characterization and prediction of natriuretic peptide “nonresponse” during heart failure management: Results from the ProBNP outpatient tailored chronic heart failure (PROTECT) and the NT-proBNP–assisted treatment to lessen serial cardiac readmissions and death (BATTLESCARRED) study. Congestive Heart Failure, 19(3), 135-142. doi: 10.1111/chf.12016

Lewis, L. K., Raudsepp, S. D., Yandle, T. G., Frampton, C. M., Palmer, S. C., Troughton, R. W., & Richards, A. M. (2013). Comparison of immunoassays for NTproBNP conducted on three analysis systems: Milliplex, Elecsys and RIA. Clinical Biochemistry, 46(4-5), 388-390. doi: 10.1016/j.clinbiochem.2012.11.022

Prickett, T. C. R., Olney, R. C., Cameron, V. A., Ellis, M. J., Richards, A. M., & Espiner, E. A. (2013). Impact of age, phenotype and cardio-renal function on plasma C-type and B-type natriuretic peptide forms in an adult population. Clinical Endocrinology, 78(5), 783-789. doi: 10.1111/cen.12035

Journal - Research Other

Loo, G., Hein, T., Tai, B.-C., Khoo, S.-M., Chan, M. Y., Chia, B.-L., Richards, M., … Lee, C.-H. (2013). Screening of hospitalized patients at high risk of obstructive sleep apnea in general cardiology service. International Journal of Cardiology, 164(3), 368-370. doi: 10.1016/j.ijcard.2012.06.072

Loo, G., Shen, L., Ho, H.-H., Richards, A. M., Ong, P., & Lee, C.-H. (2013). Relationship between CHA₆₅DS₂ score and obstructive sleep apnea (CHA₆₅DS₂ and OSA). International Journal of Cardiology, 168(5), 5037-5039. doi: 10.1016/j.ijcard.2013.07.221

Conference Contribution - Published proceedings: Abstract

Liu, M., Lee, A. P. W., Richards, A. M., Renneberg, R., Zhang, Q., Lam, C., … Yu, C. M. (2013). Predictive value of novel biomarkers for response to medical treatment in systolic heart failure. European Heart Journal, 34(Suppl. 1), (pp. 284). doi: 10.1093/eurheartj/eht308.P1479

Cullen, L., Parsonage, W., Greenslade, J., Aldous, S., George, P., Lamanna, A., … Richards, M., Pemberton, C. J., Than, M., on behalf of the Emergency Cardiology Group. (2013). Diagnostic accuracy of highly sensitive troponin I versus highly sensitive troponin T assays for acute myocardial infarction within two hours of emergency department presentation. European Heart Journal, 34(Suppl. 1), (pp. 86). doi: 10.1093/eurheartj/eht307.P484

Chung, A. C. K., Liu, M., Dong, Y., Lee, A. P. W., Lan, H. Y., Coats, A. J., Richards, A. M., … Yu, C. M. (2013). Circulating microRNAs as markers for prediction of heart failure medical treatment outcome. European Heart Journal, 34(Suppl. 1), (pp. 775). doi: 10.1093/eurheartj/eht309.P4214

Siriwardena, M., Charles, C. J., Byers, M., Richards, A. M., & Pemberton, C. J. (2013). BNP signal peptide is protective in ischaemia reperfusion injury. Heart, Lung & Circulation, 22(7), (pp. 578-579). doi: 10.1016/j.hlc.2013.04.074

Martin, A., Doughty, R. N., Chieng, N., Faatoese, A., Gamble, G. D., Poppe, K., Richards, A. M., Tikao-Mason, K., Troughton, R., Wells, E., Whalley, G. A., Cameron, V., & Pitama, S. (2013). Twelve lead electrocardiographic findings among Māori and non-Māori at risk of cardiovascular disease in NZ. Heart, Lung & Circulation, 22(7), (pp. 569). doi: 10.1016/j.hlc.2013.04.052

Conference Contribution - Poster Presentation (not in published proceedings)

Byers, M. S., Bailey, M., Siriwardena, M., Lewis, L. K., Oliver, J., Troughton, R., Richards, A. M., & Pemberton, C. J. (2013, August). Plasma ghrelin signal peptide can exclude co-existent pneumonia in acute decompensated heart failure. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Pemberton, C. J., Aldous, S., Bailey, M., Young, J., Troughton, R., Than, M., & Richards, M. (2013, August). BNP signal peptide in the diagnosis of acute coronary syndromes. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Intellectual Property

Pemberton, C. J., Richards, A. M., Nicholls, M. G., & Yandle, T. G. (2013). Biomarkers. [Marker reference: GHRDx] (8,507,209). United States.

2012

Journal - Research Article

Ellis, K. L., Pilbrow, A. P., Potter, H. C., Frampton, C. M., Doughty, R. N., Whalley, G. A., … Palmer, B. R., Skelton, L., Yandle, T. G., Troughton, R. W., Richards, A. M., & Cameron, V. A. (2012). Association between endothelin type A receptor haplotypes and mortality in coronary heart disease. Personalized Medicine, 9(3), 341-349. doi: 10.2217/PME.12.10

Lee, C.-H., Hau, W. K. T., Tai, B.-C., Chan, M. Y., Saw, B., Phua, Q.-H., … Richards, A. M., & Tan, H.-C. (2012). Adiponectin profile in Asian patients undergoing coronary revascularization and its association with plaque vulnerability: IDEAS-ADIPO study. Obesity, 20(12), 2451-2457. doi: 10.1038/oby.2012.92

Chan, M. Y., Tan, K., Tan, H.-C., Huan, P.-T., Li, B., Phua, Q.-H., … Richards, A. M., … Koay, E. (2012). CYP2C19 and PON1 polymorphisms regulating clopidogrel bioactivation in Chinese, Malay and Indian subjects. Pharmacogenomics, 13(5), 533-542. doi: 10.2217/pgs.12.24

Santhanakrishnan, R., Chong, J. P. C., Ng, T. P., Ling, L. H., Sim, D., Leong, K. T. G., … Richards, A. M., & Lam, C. S. P. (2012). Growth differentiation factor 15, ST2, high-sensitivity troponin T, and N-terminal pro brain natriuretic peptide in heart failure with preserved vs. reduced ejection fraction. European Journal of Heart Failure, 14(12), 1338-1347. doi: 10.1093/eurjhf/hfs130

Li, Y., Tai, B.-C., Sia, W., Phua, Q.-H., Richards, A. M., Low, A., … Chan, M. Y. (2012). Angiographic and platelet reactivity outcomes with prasugrel 60 mg pretreatment and clopidogrel 600 mg pretreatment in primary percutaneous coronary intervention. Journal of Thrombosis & Thrombolysis, 34(4), 499-505. doi: 10.1007/s11239-012-0782-y

McAlister, F. A., Ezekowitz, J., Tarantini, L., Squire, I., Komajda, M., Bayes-Genis, A., … Whalley, G., … and Meta-analysis Global Group in Chronic Heart Failure (MAGGIC) Investigators, including Richards, A. M. (2012). Renal dysfunction in patients with heart failure with preserved versus reduced ejection fraction: Impact of the new Chronic Kidney Disease-Epidemiology Collaboration Group formula. Circulation: Heart Failure, 5(3), 309-314. doi: 10.1161/CIRCHEARTFAILURE.111.966242

Martínez-Sellés, M., Doughty, R. N., Poppe, K., Whalley, G. A., Earle, N., Tribouilloy, C., … on behalf of the Meta-analysis Global Group in Chronic Heart Failure (MAGGIC), including Richards, A. M. (2012). Gender and survival in patients with heart failure: Interactions with diabetes and aetiology. Results from the MAGGIC individual patient meta-analysis. European Journal of Heart Failure, 14(5), 473-479. doi: 10.1093/eurjhf/hfs026

Aldous, S., Pemberton, C., Richards, A. M., Troughton, R., & Than, M. (2012). High-sensitivity troponin T for early rule-out of myocardial infarction in recent onset chest pain. Emergency Medicine Journal, 29(10), 805-810. doi: 10.1136/emermed-2011-200222

Rusinaru, D., Tribouilloy, C., Berry, C., Richards, A. M., Whalley, G. A., Earle, N., … on behalf of the MAGGIC Investigators. (2012). Relationship of serum sodium concentration to mortality in a wide spectrum of heart failure patients with preserved and with reduced ejection fraction: An individual patient data meta-analysis. European Journal of Heart Failure, 14(10), 1139-1146. doi: 10.1093/eurjhf/hfs099

Wu, A. H. B., Tabas, J., Stein, J., Potocki, M., Mueller, C., McCord, J., Richards, M., … Maisel, A. S. (2012). The effect of diabetes on the diagnostic and prognostic performance of mid-region pro-atrial natriuretic peptide and mid-region pro-adrenomedullin in patients with acute dyspnea. Biomarkers, 17(6), 490-497. doi: 10.3109/1354750x.2012.687014

Rademaker, M. T., Yandle, T. G., Ellmers, L. J., Charles, C. J., Nicholls, M. G., & Richards, A. M. (2012). Hemodynamic, hormonal, and renal effects of (pro)renin receptor blockade in experimental heart failure. Circulation: Heart Failure, 5, 645-652. doi: 10.1161/circheartfailure.112.967059

Pilbrow, A. P., Folkersen, L., Pearson, J. F., Brown, C. M., McNoe, L., Wang, N. M., … Black, M. A., Troughton, R. W., Richards, A. M., … Cameron, V. A. (2012). The chromosome 9p21.3 coronary heart disease risk allele is associated with altered gene expression in normal heart and vascular tissues. PLoS ONE, 7(6), e39574. doi: 10.1371/journal.pone.0039574

Lever, M., George, P. M., Elmslie, J. L., Atkinson, W., Slow, S., Molyneux, S. L., Troughton, R. W., Richards, A. M., Frampton, C. M., & Chambers, S. T. (2012). Betaine and secondary events in an acute coronary syndrome cohort. PLoS ONE, 7(5), e37883. doi: 10.1371/journal.pone.0037883

Lever, M., George, P. M., Atkinson, W., Elmslie, J. L., Slow, S., Molyneux, S. L., Troughton, R. W., Richards, A. M., Frampton, C. M., & Chambers, S. T. (2012). The contrasting relationships between betaine and homocysteine in two clinical cohorts are associated with plasma lipids and drug treatments. PLoS ONE, 7(3), e32460. doi: 10.1371/journal.pone.0032460

Than, M., Cullen, L., Aldous, S., Parsonage, W. A., Reid, C. M., Greenslade, J., … Ardagh, M. W., Troughton, R., … Richards, A. M. (2012). 2-Hour accelerated diagnostic protocol to assess patients with chest pain symptoms using contemporary troponins as the only biomarker: The ADAPT trial. JACC, 59(23), 2091-2098. doi: 10.1016/j.jacc.2012.02.035

Ellis, K. L., Palmer, B. R., Frampton, C. M., Troughton, R. W., Doughty, R. N., Whalley, G. A., … Pilbrow, A. P., Skelton, L., Yandle, T. G., Richards, A. M., & Cameron, V. A. (2012). Genetic variation in the renin-angiotensin-aldosterone system is associated with cardiovascular risk factors and early mortality in established coronary heart disease. Journal of Human Hypertension, 27, 237-244. doi: 10.1038/jhh.2012.24

Maisel, A., Neath, S.-X., Landsberg, J., Mueller, C., Nowak, R. M., Peacock, W. F., … Richards, M., … Anker, S. D. (2012). Use of procalcitonin for the diagnosis of pneumonia in patients presenting with a chief complaint of dyspnoea: Results from the BACH (Biomarkers in Acute Heart Failure) trial. European Journal of Heart Failure, 14(3), 278-286. doi: 10.1093/eurjhf/hfr177

Pemberton, C. J., Siriwardena, M., Kleffmann, T., Ruygrok, P., Palmer, S. C., Yandle, T. G., & Richards, A. M. (2012). First identification of circulating Prepro-A-Type natriuretic peptide (PreproANP) signal peptide fragments in humans: Initial assessment as cardiovascular biomarkers. Clinical Chemistry, 58(4), 757-767. doi: 10.1373/clinchem.2011.176990

Rademaker, M. T., Charles, C. J., Nicholls, M. G., & Richards, A. M. (2012). Haemodynamic, endocrine and renal actions of adrenomedullin 5 in an ovine model of heart failure. Clinical Science, 122(9), 429-437. doi: 10.1042/cs20110483

Cameron, V. A., Faatoese, A. F., Gillies, M. W., Robertson, P. J., Huria, T. M., Doughty, R. N., Whalley, G. A., … Richards, M. A., Troughton, R. W., Tikao-Mason, K. N., Wells, E. J., Sheerin, I. G., & Pitama, S. G. (2012). A cohort study comparing cardiovascular risk factors in rural Māori, urban Māori and non-Māori communities in New Zealand. BMJ Open, 2(3), e000799. doi: 10.1136/bmjopen-2011-000799

Patel, K., Rademaker, M. T., Kirkpatrick, C. M. J., Charles, C. J., Fisher, S., Yandle, T. G., & Richards, A. M. (2012). Comparative pharmacokinetics and pharmacodynamics of urocortins 1, 2 and 3 in healthy sheep. British Journal of Pharmacology, 166(6), 1916-1925. doi: 10.1111/j.1476-5381.2012.01904.x

Greenslade, J. H., Cullen, L., Parsonage, W., Reid, C. M., Body, R., Richards, M., … Than, M. (2012). Examining the signs and symptoms experienced by individuals with suspected acute coronary syndrome in the Asia-Pacific Region: A prospective observational study. Annals of Emergency Medicine, 60(6), 777-785.e3. doi: 10.1016/j.annemergmed.2012.05.008

Scott, N. J. A., Cameron, V. A., Raudsepp, S., Lewis, L. K., Simpson, E. R., Richards, A. M., & Ellmers, L. J. (2012). Generation and characterization of a mouse model of the metabolic syndrome: Apolipoprotein E and aromatase double knockout mice. American Journal of Physiology: Endocrinology & Metabolism, 302, E576-E584. doi: 10.1152/ajpendo.00222.2011

Daniels, L. B., Clopton, P., Potocki, M., Mueller, C., McCord, J., Richards, M., … Maisel, A. S. (2012). Influence of age, race, sex, and body mass index on interpretation of midregional pro atrial natriuretic peptide for the diagnosis of acute heart failure: Results from the BACH multinational study. European Journal of Heart Failure, 14(1), 22-31. doi: 10.1093/eurjhf/hfr157

Schouten, B. J., Prickett, T. C., Hunt, P. J., Richards, A. M., Geffner, M. E., Olney, R. C., & Espiner, E. A. (2012). C-type natriuretic peptide forms in adult hyperthyroidism: Correlation with thyroid hormones and markers of bone turnover. Clinical Endocrinology, 76(6), 790-796. doi: 10.1111/j.1365-2265.2011.04295.x

Palmer, B. R., Frampton, C. M., Skelton, L., Yandle, T. G., Doughty, R. N., Whalley, G. A., … Troughton, R. W., Richards, A. M., & Cameron, V. A. (2012). KCNE5 polymorphism rs697829 is associated with QT interval and survival in acute coronary syndromes patients. Journal of Cardiovascular Electrophysiology, 23(3), 319-324. doi: 10.1111/j.1540-8167.2011.02192.x

Journal - Research Other

Siriwardena, M., Campbell, V., Richards, A. M., & Pemberton, C. J. (2012). Cardiac biomarker responses to dobutamine stress echocardiography in healthy volunteers and patients with coronary artery disease. Clinical Chemistry, 58(10), 1492-1494. doi: 10.1373/clinchem.2012.187682

Richards, M. (2012). Biomarkers and silent cardiac disease in primary prevention: Time to unmask the damage? JACC, 60(11), 969-970. doi: 10.1016/j.jacc.2012.05.030

Sheerin, I., Pitama, S., Wells, J. E., Faatoese, A., Richards, M., Troughton, R., Tikao-Mason, K., Huria, T., Robertson, P., Gillies, M., … Whalley, G., & Cameron, V. (2012). Loose tobacco, ethnicity, income and rurality. Australian & New Zealand Journal of Public Health, 36(3), 291-292. doi: 10.1111/j.1753-6405.2012.00873.x

Aldous, S., Pemberton, C., Troughton, R., Than, M., & Richards, A. M. (2012). Heart fatty acid binding protein and myoglobin do not improve early rule out of acute myocardial infarction when highly sensitive troponin assays are used. Resuscitation, 83(2), e27-e28. doi: 10.1016/j.resuscitation.2011.09.031

Journal - Professional & Other Non-Research Articles

Aldous, S., Pemberton, C., Richards, A. M., Troughton, R., & Than, M. (2012). Authors' response. Emergency Medicine Journal, 29(7), 601-602. doi: 10.1136/emermed-2012-201216

Conference Contribution - Published proceedings: Abstract

Cordeddu, L., Pilbrow, A. P., Cameron, V. A., Troughton, R. W., Richards, M. A., & Roger, S. (2012). Circulating miRNAs as biomarkers in acute coronary syndrome. Circulation Research, 111(4 Suppl. 1). [Abstract]

Charles, C. J., Rademaker, M. T., Jardine, D. L., Chan, W., Ellmers, L. J., Troughton, R. W., & Richards, A. M. (2012). Urocortin 2: Neurohumoral mechanisms in heart disease. Heart, Lung & Circulation, 21(12), (pp. 863). doi: 10.1016/j.hlc.2012.08.033

Faatoese, A., Pitama, S., Wells, J. E., Tikao-Mason, K., Robertson, P., Huria, T., Gillies, T., … Troughton, R., Sheerin, I., Richards, M., & Cameron, V. A. (2012). A Māori approach to a community-based study of heart health among Māori and non-Māori communities: Baseline findings in the Hauora Manawa/Community Heart Study. In C. Matthewson, M. Taumoepeau, G. Burnett & I. Iati (Eds.), Proceedings of the Pacific Postgraduate Symposium: Pacific Voices IX. (pp. 17). Dunedin, New Zealand: Pacific Islands Centre, University of Otago. [Abstract]

Jackson, C. E., Doughty, R. N., Poppe, K., Squire, I., Kober, L., Andersson, B., … Richards, A. M., … on behalf of MAGGIC study group. (2012). Lower pulse pressure predicts mortality in patients with heart failure with preserved (HF-PEF) and reduced left ventricular ejection fraction (HF-REF). European Heart Journal, 33, (pp. 649-650). doi: 10.1093/eurheartj/ehs282

Prickett, T. C. R., Olney, R., Cameron, V. A., Ellis, J., Richards, A. M., & Espiner, E. A. (2012). Age dependent changes in CNP in humans: New insights linking skeletal growth and vascular integrity. Proceedings of the Medical Sciences Congress (MedSci). (pp. 50). Retrieved from http://www.medscinz.co.nz/QRW2012%20MedSci%20Abstracts.pdf

Charles, C. J., Jardine, D. L., & Richards, A. M. (2012). B-type natriuretic peptide at non hypotensive doses raises cardiac sympathetic nerve activity in sheep. Proceedings of the Medical Sciences Congress (MedSci). (pp. 29). Retrieved from http://www.medscinz.co.nz/QRW2012%20MedSci%20Abstracts.pdf

Byers, M. S., Siriwardena, M., Ruygrok, P., Yandle, T., Kleffmann, T., Richards, A. M., & Pemberton, C. J. (2012). Ghrelin signal peptide (GHRSP): Identification, immunoassay and circulating profile. Proceedings of the Medical Sciences Congress (MedSci). (pp. 18). Retrieved from http://www.medscinz.co.nz/QRW2012%20MedSci%20Abstracts.pdf

Ellis, C. J., Gamble, G. D., Hamer, A., Devlin, G., Elliott, J. M., Matsis, P., Williams, M. J. A., Mann, S., … Richards, A. M., … For the Cardiac Society NZ ACS Audit Group. (2012). Is the mortality risk following an acute coronary syndrome (ACS) admission to a non-intervention centre related to access to cardiac angiography? Eighteen month follow-up of the 2002/2007 New Zealand (NZ) ACS audits. Heart, Lung & Circulation, 21(8), (pp. 488). doi: 10.1016/j.hlc.2012.03.034

Ellis, C. J., Gamble, G. D., Devlin, G., Hamer, A., Elliott, J. M., Matsis, P., Williams, M. J. A., Mann, S., … Richards, A. M., … For the Cardiac Society NZ ACS Audit Group. (2012). All cause mortality following an acute coronary syndrome (ACS) admission: Six year follow-up of the 2002 New Zealand (NZ) acute coronary syndromes audit. Heart, Lung & Circulation, 21(8), (pp. 487-488). doi: 10.1016/j.hlc.2012.03.033

Chan, W., Troughton, R., Frampton, C., Crozier, I., & Richards, M. (2012). Integrated effects of Urocortin-2 infusion in patients with acute decompensated heart failure: Findings from a randomised controlled clinical trial. Heart, Lung & Circulation, 21(8), (pp. 483). doi: 10.1016/j.hlc.2012.03.024

Chan, W., Jardine, D., Butler, J., Charles, C., Troughton, R., & Richards, M. (2012). Urocortin-2 increases muscle sympathetic nerve activity (MSNA) in healthy man. Heart, Lung & Circulation, 21(8), (pp. 482). doi: 10.1016/j.hlc.2012.03.022

Intellectual Property

Pemberton, C. J., Richards, A. M., Nicholls, M. G., & Yandle, T. G. (2012). Methods of diagnosing acute cardiac disorders using BNP-SP. [Marker reference: BNPDx] (8,289,772). United States.

2011

Chapter in Book - Research

Richards, A. M., Troughton, R. W., & Nicholls, M. G. (2011). Natriuretic peptides for guidance of acute and chronic heart failure therapy. In J. L. Januzzi (Ed.), Cardiac biomarkers in clinical practice. (pp. 559-580). Sudbury, MA: Jones & Bartlett.

Journal - Research Article

Ellis, K. L., Newton-Cheh, C., Wang, T. J., Frampton, C. M., Doughty, R. N., Whalley, G. A., … Skelton, L., Davis, N., Yandle, T. G., Troughton, R. W., Richards, A. M., & Cameron, V. A. (2011). Association of genetic variation in the natriuretic peptide system with cardiovascular outcomes. Journal of Molecular & Cellular Cardiology, 50(4), 695-701. doi: 10.1016/j.yjmcc.2011.01.010

Ellis, K. L., Frampton, C. M., Pilbrow, A. P., Troughton, R. W., Doughty, R. N., Whalley, G. A., … Skelton, L., Thomson, J. A., Yandle, T. G., Richards, A. M., & Cameron, V. A. (2011). Genomic risk variants at 1p13.3, 1q41, and 3q22.3 are associated with subsequent cardiovascular outcomes in healthy controls and in established coronary artery disease. Circulation: Cardiovascular Genetics, 4(6), 636-646. doi: 10.1161/circgenetics.111.960336

Faatoese, A. F., Pitama, S. G., Gillies, T. W., Robertson, P. J., Huria, T. M., Tikao-Mason, K. N., … Whalley, G. A., Richards, A. M., Troughton, R. W., Sheerin, I. G., Wells, J. E., & Cameron, V. A. (2011). Community screening for cardiovascular risk factors and levels of treatment in a rural Māori cohort. Australian & New Zealand Journal of Public Health, 35(6), 517-523. doi: 10.1111/j.1753-6405.2011.00777.x

Richards, A. M., & Troughton, R. W. (2011). Use of natriuretic peptides to guide and monitor heart failure therapy. Clinical Chemistry, 58(1), 62-71. doi: 10.1373/clinchem.2011.165704

Richards, A. M. (2011). Mineralocorticoid receptor antagonists for heart failure. Expert Opinion on Pharmacotherapy, 12(18), 2801-2815. doi: 10.1517/14656566.2011.631524

Prickett, T. C. R., Bothwell, J. C., Yandle, T. G., Richards, A. M., & Espiner, E. A. (2011). Pharmacodynamic responses of plasma and tissue C-type natriuretic peptide to GH: Correlation with linear growth in GH-deficient rats. Journal of Endocrinology, 15, 217-225. doi: 10.1530/joe-11-0387

Maisel, A., Xue, Y., Shah, K., Mueller, C., Nowak, R., Peacock, W. F., … Richards, M., … Anker, S. D. (2011). Increased 90-day mortality in patients with acute heart failure with elevated copeptin: Secondary results from the Biomarkers in Acute Heart Failure (BACH) study. Circulation: Heart Failure, 4(5), 613-620. doi: 10.1161/CIRCHEARTFAILURE.110.960096

Hamid, A. K., Richards, A. M., Crozier, I. G., Lainchbury, J. G., Melton, I., Bridgman, P. G., Palmer, S. C., Frampton, C. M., & Nicholls, M. G. (2011). Prediction of cardiac rhythm 1 year following cardioversion for atrial fibrillation. New Zealand Medical Journal, 124(1343). Retrieved from http://journal.nzma.org.nz/journal/124-1343/4881/content.pdf

Peacock, W. F., Nowak, R., Christenson, R., DiSomma, S., Neath, S. X., Hartmann, O., … Richards, M., … Maisel, A. S. (2011). Short-term mortality risk in emergency department acute heart failure. Academic Emergency Medicine, 18(9), 947-958. doi: 10.1111/j.1553-2712.2011.01150.x

Ritzema, J. L., Richards, A. M., Crozier, I. G., Frampton, C., Melton, I. C., Doughty, R. N., … Troughton, R. W. (2011). Serial Doppler echocardiography and tissue Doppler imaging in the detection of elevated directly measured left atrial pressure in ambulant subjects with chronic heart failure. JACC: Cardiovascular Imaging, 4(9), 927-934. doi: 10.1016/j.jcmg.2011.07.004

Maisel, A., Mueller, C., Nowak, R., …, Richards, M., …, & Anker, S. D. (2011). Midregion prohormone adrenomedullin and prognosis in patients presenting with acute dyspnea: Results from the BACH (Biomarkers in Acute Heart Failure) Trial. JACC, 58(10), 1057-1067. doi: 10.1016/j.jacc.2011.06.006

Lever, M., George, P. M., Atkinson, W., Molyneux, S. L., Elmslie, J. L., Slow, S., Richards, A. M., & Chambers, S. T. (2011). Plasma lipids and betaine are related in an acute coronary syndrome cohort. PLoS ONE, 6(7), e21666. doi: 10.1371/journal.pone.0021666

Rademaker, M. T., Charles, C. J., Nicholls, G., & Richards, M. (2011). Urocortin 2 sustains haemodynamic and renal function during introduction of beta-blockade in experimental heart failure. Journal of Hypertension, 29, 1787-1795. doi: 10.1097/HJH.0b013e3283493776

Charles, C. J., Jardine, D. L., Rademaker, M. T., & Richards, M. (2011). Urocortin 3 inhibits cardiac sympathetic nerve activity in conscious sheep. Journal of Cardiovascular Pharmacology, 58(4), 418-423. doi: 10.1097/FJC.0b013e31822707a4

Pitama, S., Wells, J. E., Faatoese, A., Tikao-Mason, K., Robertson, P., Huria, T., Gillies, T., … Whalley, G., Troughton, R., Sheerin, I., Richards, M., & Cameron, V. A. (2011). A Kaupapa Māori approach to a community cohort study of heart disease in New Zealand. Australian & New Zealand Journal of Public Health, 35(3), 249-255. doi: 10.1111/j.1753-6405.2011.00702.x

Rademaker, M. T., Charles, C. J., Ellmers, L. J., Lewis, L. K., Nicholls, M. G., & Richards, A. M. (2011). Prolonged urocortin 2 administration in experimental heart failure: Sustained hemodynamic, endocrine, and renal effects. Hypertension, 57, 1136-1144. doi: 10.1161/HYPERTENSIONAHA.111.173203

Charles, C. J., Rademaker, M. T., & Richards, A. M. (2011). Hemodynamic, hormonal, and renal actions of adrenomedullin-5 in normal conscious sheep. Journal of Cardiovascular Pharmacology, 58(1), 25-31. doi: 10.1097/FJC.0b013e31821a9473

Than, M., Cullen, L., Reid, C. M., Lim, S. H., Aldous, S., Ardagh, M. W., … George, P. M., & Richards, A. M. (2011). A 2-h diagnostic protocol to assess patients with chest pain symptoms in the Asia-Pacific region (ASPECT): A prospective observational validation study. Lancet, 377(9771), 1077-1084. doi: 10.1016/S0140-6736(11)60310-3

Schouten, B. J., Prickett, T. C. R., Hooper, A. A., Hooper, G. J., Yandle, T. G., Richards, A. M., & Espiner, E. A. (2011). Central and peripheral forms of C-type natriuretic peptide (CNP): Evidence for differential regulation in plasma and cerebrospinal fluid. Peptides, 32(4), 797-804. doi: 10.1016/j.peptides.2011.01.013

Rademaker, M. T., Charles, C. J., Melton, I. C., Richards, A. M., Frampton, C. M., Siou, J., … Troughton, R. W. (2011). Monitoring of heart failure: Comparison of left atrial pressure with intrathoracic impedance and natriuretic peptide measurements in an experimental model of ovine heart failure. Clinical Science, 120(5), 207-217. doi: 10.1042/CS20100388

Journal - Research Other

Pearson, S., Troughton, R., & Richards, A. M. (2011). Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. New England Journal of Medicine, 365(24), 2334-2335. [Letter].

Richards, A. M., Lam, C., Wong, R. C., & Ping, C. (2011). Heart failure: A problem of our age [Editorial]. Annals Academy Medicine Singapore, 40(9), 392-393.

Pemberton, C. J., Richards, A. M., Siriwardena, M., Cameron, V. A., Yandle, T. G., Nicholls, M. G., Kleffmann, T., & Ruygrok, P. (2011). [Response to letter regarding article, B-Type natriuretic peptide signal peptide circulates in human blood: Evaluation as a potential biomarker of cardiac ischemia]. Circulation, 123(6), e234. doi: 10.1161/CIRCULATIONAHA.110.003574

Journal - Professional & Other Non-Research Articles

Than, M., Cullen, L., Reid, C. M., Lim, S. H., & Richards, M. (2011). Rapid diagnostic protocol for patients with chest pain: Authors' reply [Letter]. Lancet, 378(9789), 398-399. doi: 10.1016/S0140-6736(11)61206-3

Conference Contribution - Published proceedings: Full paper

Richards, A. M. (2011). Tailored therapy for heart failure: Neurohormones. Canadian Journal of Physiology and Pharmacology. 89(8), (pp. 603-607). doi: 10.1139/y11-036

Conference Contribution - Published proceedings: Abstract

Schouten, B. J., Prickett, T. C., Hunt, P. J., Richards, M., & Espiner, E. A. (2011). CNP forms in adult hyperthyroidism: Correlation with thyroid hormones and markers of bone turnover. Endocrine Reviews, 32(3, Suppl.), P2-109. Retrieved from http://press.endocrine.org/series/endo-meetings

Aldous, S., Than, M., & Richards, M. (2011). ST2 predicts heart failure and all cause mortality in patients presenting to the Emergency Department with chest pain. Proceedings of the 60th American College of Cardiology (ACC) Annual Scientific Session. Retrieved from www.accscientificsession.org

Pilbrow, A. P., Pearson, J. F., McNoe, L., Ellis, K. L., Black, M. A., Sweet, W. E., … Troughton, R. W., Richards, A. M., … Cameron, V. A. (2011). Chromosome 1q41 and 3q22.3 coronary artery disease risk loci are associated with altered cardiac gene expression profiles in normal and diseased heart. Circulation, 124, A12170. [Abstract]

Ellmers, L. J., Richards, M. A., Charles, C. J., & Rademaker, M. T. (2011). (Pro)renin receptor blockade improves cardiac function and reduces ventricular remodeling following myocardial infarction in mice. European Heart Journal, 32(Suppl. 1), (pp. 693). doi: 10.1093/eurheartj/ehr324

Nedoboy, P., Morgan, P. E., Mocatta, T. J., Richards, M. A., Winterbourn, C. C., & Davies, M. J. (2011). Plasma levels of myeloperoxidase (MPO) and thiocyanate (SCN^-) predict mortality in patients following acute myocardial infarction. Free Radical Biology & Medicine, 51(Suppl. 1), (pp. S47). doi: 10.1016/j.freeradbiomed.2011.10.118

Marshall, C. J., McKenzie, J. L., Moccata, T., Nallaratnam, M., Blake, J., Frampton, C., Richards, M., Kettle, A. J., & McClean, D. R. (2011). Neutrophil activation at the culprit lesion in acute ST-segment elevation myocardial infarction with multiple complex coronary plaques. Heart, 97(Suppl. 1), (pp. A11-A12). doi: 10.1136/heartjnl-2011-300198.13

Cameron, V., Faatoese, A., Gillies, M., Robertson, P., Huria, T., Doughty, R., Whalley, G., Richards, M., Troughton, R., Tikao-Mason, K., Sheerin, I., Wells, E., & Pitama, S. (2011). How to successfully undertake genetics research in partnership with indigenous Maori communities. Internal Medicine Journal. 41(Suppl. 2), (pp. 4). doi: 10.1111/j.1445-5994.2011.02486.x

Aldous, S., Richards, A. M., & Than, M. (2011). Can high sensitivity troponin accelerate current diagnostic protocols for the diagnosis of acute myocardial infarction. Heart, Lung & Circulation, 20(6), (pp. 376). doi: 10.1016/j.hlc.2011.03.015

Aldous, S., Richards, A. M., & Than, M. (2011). ST2 measurement predicts death and heart failure in patients presenting to the Emergency Department with chest pain. Heart, Lung & Circulation, 20(6), (pp. 376). doi: 10.1016/j.hlc.2011.03.016

Conference Contribution - Poster Presentation (not in published proceedings)

Ellis, K. L., Frampton, C. M., Pilbrow, A. P., Troughton, R. W., Doughty, R. N., Whalley, G. A., … Yandle, T. G., Richards, A. M., & Cameron, V. A. (2011, August). Genomic risk variants at 1p13.3, 1q41 and 3q22.3 are associated with subsequent cardiovascular outcomes in healthy controls and in patients with established coronary artery disease. Poster session presented at the European Society of Cardiology (ESC) Congress, Paris, France.

Ellis, K. L., Palmer, B. R., Pilbrow, A. P., Troughton, R. W., Doughty, R. N., Whalley, G. A., … Yandle, T. G., Richards, A. M., & Cameron, V. A. (2011, August). Genetic variation within the renin-angiotensin-aldosterone hormone system is associated with cardiovascular risk factors and subsequent readmission for non ST-elevation myocardial infarction. Poster session presented at the European Society of Cardiology (ESC) Congress, Paris, France.

Faatoese, A., Pitama, S., Wells, J. E., Tikao-Mason, K., Robertson, P., Huria, T., Gillies, T., … Troughton, R., Sheerin, I., Richards, A. M., & Cameron, V. A. (2011, September). Genomewide association studies (GWAS) variants were not associated with coronary artery disease (CAD) and type 2 diabetes (DM2) in Maori and non-Maori community cohorts: The Hauora Manawa Project. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Palmer, B. R., Ellis, K. L., Pilbrow, A. P., Slow, S., Lever, M., Palmer, S. C., Skelton, L., Frampton, C. M., Troughton, R. W., Yandle, T. G., … Chambers, S. T., George, P. M., Richards, A. M., & Cameron, V. A. (2011, September). Folate pathway genetics, homocysteine and survival in coronary heart patients. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Charles, C. J., Espiner, E. A., Nicholls, M. G., Pemberton, C. J., Troughton, R. W., Yandle, T. G., & Richards, A. M. (2011, September). Cardiac biomarkers: Clinical utility for diagnosis, prognosis and guiding treatment of cardiovascular disease. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Pilbrow, A. P., Pearson, J. F., Brown, C. M., McNoe, L., Sweet, W. E., Tang, W. H. W., Black, M. A., Troughton, R. W., Richards, A. M., … Cameron, V. A. (2011, September). Cardiac gene expression profiling. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Intellectual Property

Prickett, T. C. R., Espiner, E. A., Richards, A. M., Yandle, T. G., & Nicholls, M. G. (2011). Assessment of skeletal growth using measurements of NT-CNP peptides. (US 7,919,255).

2010

Journal - Research Article

Stewart, R. A. H., Kerr, A. J., Whalley, G. A., Legget, M. E., Zeng, I., Williams, M. J. A., Lainchbury, J., … Richards, M. A., … for the New Zealand Heart Valve Study Investigators. (2010). Left ventricular systolic and diastolic function assessed by tissue Doppler imaging and outcome in asymptomatic aortic stenosis. European Heart Journal, 31(18), 2216-2222. doi: 10.1093/eurheartj/ehq159

Poppe, K. K., Whalley, G. A., Richards, A. M., Wright, S. P., Triggs, C. M., & Doughty, R. N. (2010). Prediction of ACC/AHA stage B heart failure by clinical and neurohormonal profiling among patients in the community. Journal of Cardiac Failure, 16(12), 957-963. doi: 10.1016/j.cardfail.2010.07.247

Hildebrandt, P., Collinson, P. O., Doughty, R. N., Fuat, A., Gaze, D. C., Gustafsson, F., … Richards, M. (2010). Age-dependent values of N-terminal pro-B-type natriuretic peptide are superior to a single cut-point for ruling out suspected systolic dysfunction in primary care. European Heart Journal, 31(15), 1881-1889. doi: 10.1093/eurheartj/ehq163

Shrestha, K., Troughton, R. W., Borowski, A. G., Yandle, T. G., Richards, A. M., Klein, A. L., & Tang, W. H. W. (2010). Plasma corin levels provide minimal prognostic utility incremental to natriuretic peptides in chronic systolic heart failure. Journal of Cardiac Failure, 16(8), 621-627. doi: 10.1016/j.cardfail.2010.03.010

Richards, A. M. (2010). B-type natriuretic peptide-guided therapy for chronic heart failure reduces all-cause mortality compared with usual care but does not affect all-cause hospitalisation or survival free of hospitalisation. Evidence-Based Medicine, 15(5), 137-138. doi: 10.1136/ebm1084

Ellis, C., Gamble, G., Hamer, A., Williams, M., Matsis, P., Elliott, J., … Richards, M., … for the New Zealand Acute Coronary Syndromes (NZACS) Audit Group. (2010). Patients admitted with an acute coronary syndrome in New Zealand in 2007: Results of a second comprehensive nationwide audit and a comparison with the first audit from 2002. New Zealand Medical Journal, 123(1319). Retrieved from http://journal.nzma.org.nz/journal/123-1319/4235/content.pdf

Ellis, C., Devlin, G., Elliott, J., Matsis, P., Williams, M., Gamble, G., … Richards, M., … for the New Zealand Acute Coronary Syndromes (NZACS) Audit Group. (2010). ACS patients in New Zealand experience significant delays to access cardiac investigations and revascularisation treatment especially when admitted to non-interventional centres: Results of the second comprehensive national audit of ACS patients. New Zealand Medical Journal, 123(1319). Retrieved from http://journal.nzma.org.nz/journal/123-1319/4237/content.pdf

Marshall, C. J., Nallaratnam, M., Mocatta, T., Smyth, D., Richards, M., Elliott, J. M., Blake, J., Winterbourn, C. C., Kettle, A. J., & McClean, D. R. (2010). Factors influencing local and systemic levels of plasma myeloperoxidase in ST-segment elevation acute myocardial infarction. American Journal of Cardiology, 106(3), 316-322. doi: 10.1016/j.amjcard.2010.03.028

Siriwardena, M., Kleffmann, T., Ruygrok, P., Cameron, V. A., Yandle, T. G., Nicholls, M. G., Richards, A. M., & Pemberton, C. J. (2010). B-type natriuretic peptide signal peptide circulates in human blood. Evaluation as a potential biomarker of cardiac ischemia. Circulation, 122, 255-264. doi: 10.1161/CIRCULATIONAHA.109.909937

Ellis, K. L., Pilbrow, A. P., Frampton, C. M., Doughty, R. N., Whalley, G. A., Ellis, C. J., Palmer, B. R., Skelton, L., Yandle, T. G., Palmer, S. C., Troughton, R. W., Richards, A. M., & Cameron, V. A. (2010). A common variant at chromosome 9P21.3 is associated with age of onset of coronary disease but not subsequent mortality. Circulation: Cardiovascular Genetics, 3(3), 286-293. doi: 10.1161/circgenetics.109.917443

Richards, A. M. (2010). New biomarkers in heart failure: Applications in diagnosis, prognosis and guidance of therapy. Revista Española de Cardiología: English Edition, 63(6), 635-639.

Prickett, T. C. R., Ryan, J. F., Wellby, M., Barrell, G. K., Yandle, T. G., Richards, A. M., & Espiner, E. A. (2010). Effect of nutrition on plasma C-type natriuretic peptide forms in adult sheep: Evidence for enhanced C-type natriuretic peptide degradation during caloric restriction. Metabolism, 59(6), 796-801. doi: 10.1016/j.metabol.2009.09.026

Tang, W. H. W., Shrestha, K., Martin, M. G., Borowski, A. G., Jasper, S., Yandle, T. G., Richards, A. M., … Troughton, R. W. (2010). Clinical significance of endogenous vasoactive neurohormones in chronic systolic heart failure. Journal of Cardiac Failure, 16(8), 635-640. doi: 10.1016/j.cardfail.2010.03.011

Prosser, H. C., Richards, A. M., Forster, M. E., & Pemberton, C. J. (2010). Regional vascular response to ProAngiotensin-12 (PA12) through the rat arterial system. Peptides, 31, 1540-1545. doi: 10.1016/j.peptides.2010.05.009

Maisel, A., Mueller, C., Nowak, R., Peacock, F., Landsberg, J., Ponikowski, P., … Richards, M., … Anker, S. D. (2010). Mid-region pro-hormone markers for diagnosis and prognosis in acute dyspnea: Results from the BACH (Biomarkers in Acute Heart Failure) trial. JACC, 55(19), 2062-2076. doi: 10.1016/j.jacc.2010.02.025

Cullen, L., Than, M., Brown, A. F. T., Richards, M., & et al (2010). Comprehensive standardized data definitions for acute coronary syndrome research in emergency departments in Australasia. Emergency Medicine Australasia, 22(1), 35-55. doi: 10.1111/j.1742-6723.2010.01256.x

Ritzema, J., Troughton, R., Melton, I., Crozier, I., Doughty, R., Krum, H., … Richards, M., … Frampton, C. M., … on behalf of the Hemodynamically Guided Home Self-Therapy in Severe Heart Failure Patients (HOMEOSTASIS) Study Group. (2010). Physician-directed patient self-management of left atrial pressure in advanced chronic heart failure. Circulation, 121, 1086-1095. doi: 10.1161/CIRCULATIONAHA.108.800490

Charles, C. J., Rademaker, M. T., Nicholls, M. G., & Richards, A. M. (2010). Adrenomedullin 2 attenuates the pressor but not adrenal responses to angiotensin II in conscious sheep. Peptides, 31, 878-882. doi: 10.1016/j.peptides.2010.02.010

Jarvis, M. D., Palmer, B. R., Pilbrow, A. P., Ellis, K. L., Frampton, C. M., Skelton, L., … Whalley, G. A., … Yandle, T. G., Richards, A. M., & Cameron, V. A. (2010). CYP1A1 MSPI (T6235C) gene polymorphism is associated with mortality in acute coronary syndrome patients. Clinical & Experimental Pharmacology & Physiology, 37(2), 193-198. doi: 10.1111/j.1440-1681.2009.05261.x

Lainchbury, J. G., Troughton, R. W., Strangman, K. M., Frampton, C. M., Pilbrow, A., Yandle, T. G., … Nicholls, M. G., & Richards, A. M. (2010). N-terminal pro-B-type natriuretic peptide-guided treatment for chronic heart failure: Results from the BATTLESCARRED (NT-proBNP-assisted treatment to lessen serial cardiac readmissions and death) trial. JACC, 55(1), 53-60. doi: 10.1016/j.jacc.2009.02.095

Paton, L. N., Mocatta, T. J., Richards, A. M., & Winterbourn, C. C. (2010). Increased thrombin-induced polymerization of fibrinogen associated with high protein carbonyl levels in plasma from patients post myocardial infarction. Free Radical Biology & Medicine, 48(2), 223-229. doi: 10.1016/j.freeradbiomed.2009.10.044

Charles, C. J., Jardine, D. L., Rademaker, M. T., & Richards, A. M. (2010). Urocortin 2 induces potent long-lasting inhibition of cardiac sympathetic drive despite baroreflex activation in conscious sheep. Journal of Endocrinology, 204, 181-189. doi: 10.1677/JOE-08-0505

Journal - Research Other

Richards, A. M. (2010). C-type natriuretic peptide and cardiac fibrosis [Editorial]. Hypertension, 57, 154-155. doi: 10.1161/HYPERTENSIONAHA.110.163865

Richards, A. M. (2010). Nuevos biomarcadores en la insuficiencia cardiaca: Aplicaciones en el diagnóstico, pronóstico y pautas de tratamiento [Editorial]. Revista Española de Cardiología, 63(6), 635-639. doi: 10.1016/S0300-8932(10)70155-X

Conference Contribution - Published proceedings: Full paper

Pitama, S., Cameron, V., Huria, T., Gillies, M., Whalley, G., Doughty, R., Richards, M., Faatoese, A., Tikao-Mason, K., & Robertson, P. (2010). Hauora Manawa/Heart Health: The Community Heart Study. In R. Taonui (Ed.), Proceedings of Ngā Kete a Rēhua Inaugural Māori Research Symposium Te Waipounamu. (pp. 156-163). Christchurch, New Zealand: Aotahi School of Māori and Indigenous Studies, University of Canterbury. [Full Paper]

Conference Contribution - Published proceedings: Abstract

Kleffmann, T., Siriwardena, M., Ruygrok, P., Cameron, V. A., Yandle, T. G., Nicholls, M. G., Richards, A. M., & Pemberton, C. J. (2010). Characterisation of unusual modifications of the circulating signal peptide of B-type naturetic peptide: A potential biomarker of cardiac ischemia. Proceedings of the 9th Human Proteome World Congress (HUPO): Launch of the Human Proteome Project. (pp. 106). Retrieved from http://www.hupo.org/congress/congress_2010/downloads/HUPO2010%20World%20Congress%20Abstract%20Book.pdf

Yandle, T. G., Mahagamasekera, P. M. G., Ruygrok, P., Palmer, S. C., Ansell, G., Nicholls, G., Pemberton, C. J., & Richards, M. (2010). Cardiac tissue, coronary sinus and circulating forms of B-type natriuretic peptide in in patients with and without heart failure. Endocrine Journal. 57(Suppl. 2), (pp. S325). [Abstract]

Prickett, T. C. R., Bothwell, J. C., Yandle, T. G., Richards, A. M., & Espiner, E. A. (2010). Pharmacodynamic responses of C-type natriuretic peptide to GH in growth hormone deficient rats: Correlation with linear growth. Endocrine Reviews, 31(3, Suppl. 1), (pp. S1948). [Abstract]

Aldous, S., Richards, M., & Than, M. (2010). ASPECT (Asia Pacific Evaluation of Chest Pain Trial): New Zealand arm. Heart, Lung & Circulation, 19(Suppl. 2), (pp. S22-S23). doi: 10.1016/j.hlc.2010.06.716

Aldous, S., Richards, M., & Than, M. (2010). ASPECT (Asia Pacific Evaluation of Chest Pain Trial): New Zealand arm. Heart, Lung & Circulation, 19(Suppl. 1), (pp. S3). doi: 10.1016/j.hlc.2010.04.005

Scott, N. J. A., Ellis, K. L., Ellmers, L. J., Frampton, C. M., Skelton, L., Doughty, R. N., … Whalley, G. A., Yandle, T. G., Richards, A. M., & Cameron, V. A. (2010). Apolipoprotein E isoforms are associated with age of onset of coronary disease but not subsequent mortality in a coronary disease cohort. Endocrine Journal. 57(Suppl. 2), (pp. S575). [Abstract]

Scott, N. J. A., Ellmers, L. J., Raudsepp, S., Simpson, E. R., Richards, A. M., & Cameron, V. A. (2010). Characterising the Aromatase and apolipoprotein E deficient mouse for studying the metabolic syndrome. Endocrine Journal. 57(Suppl. 2), (pp. S574-S575). [Abstract]

Scott, N., Cameron, V., Simpson, E., Richards, M., & Ellmers, L. (2010). Metabolic syndrome alters expression levels of metabolic disease risk loci genes. Heart, Lung & Circulation, 19(Suppl. 2), (pp. S59). doi: 10.1016/j.hlc.2010.06.807

Faatoese, A., Pitama, S., Gillies, M., Robertson, P., Huria, T., Doughty, R., Whalley, G., Richards, M., Troughton, R., Wells, E., Sheerin, I., & Cameron, V. (2010). A comparison of metabolic risk profiles among rural and urban maori in New Zealand. Heart, Lung & Circulation, 19(Suppl. 2), (pp. S254). doi: 10.1016/j.hlc.2010.06.622

Ellmers, L., Scott, N., Cameron, V., Richards, M., & Rademaker, M. (2010). Chronic urocortin 2 treatment significantly improves cardiovascular function and attenuates cardiac injury and remodelling after experimental myocardial infarction. Heart, Lung & Circulation, 19(Suppl. 2), (pp. S49). doi: 10.1016/j.hlc.2010.06.784

Ellis, K., Newton-Cheh, C., Wang, T., Frampton, C., Doughty, R., Whalley, G., … Davis, N., Skelton, L., Yandle, T., Troughton, R., Richards, M., & Cameron, V. (2010). Association of genetic variation in the natriuretic peptide system with cardiovascular outcomes. Heart, Lung & Circulation, 19(Suppl. 2), (pp. S230). doi: 10.1016/j.hlc.2010.06.557

Elliott, J., Richards, M., Davis, N., Aldous, S., & Smyth, D. (2010). Fourteen year follow-up after Direct Percutaneous Intervention (DPCI) with remote surgical backup for anterior ST Elevation Myocardial Infarction (STEMI). Heart, Lung & Circulation, 19(Suppl. 2), (pp. S132). doi: 10.1016/j.hlc.2010.06.979

Irvine, J., Ellis, K., Frampton, C., Richards, M., Endre, Z., Leikis, M., & Cameron, V. (2010). Gene variants of the renin-angiotensin system in kidney transplantation: Are they important? Scottish Medical Journal. 55(2), (pp. 49-50). [Abstract]

Elliott, J. M., Richards, A. M., Davis, N. W., Aldous, S. J., & Smyth, D. W. (2010). Fourteen year follow-up after Direct Percutaneous Intervention (DPCI) with remote surgical backup for anterior ST Elevation Myocardial Infarction (STEMI). Heart, Lung & Circulation, 19(Suppl. 1), (pp. S10). doi: 10.1016/j.hlc.2010.04.019

Conference Contribution - Poster Presentation (not in published proceedings)

Scott, N. J. A., Ellis, K. L., Ellmers, L. J., Frampton, C. M., Skelton, L., Doughty, R. N., … Yandle, T. G., Richards, A. M., & Cameron, V. A. (2010, November-December). Apolipoprotein E isoforms are associated with age of onset of coronary disease but not subsequent mortality in a coronary disease cohort. Poster session presented at the Medical Sciences Congress: A New Decade of Discovery (MedSciNZ), Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Richards, M. (2010, June). New biomarkers in heart failure: Beyond the BNPs. Verbal presentation at the 13th International Conference on Emergency Medicine (ICEM): The World Moves Forward, Singapore.

Scott, N. J. A., Cameron, V. A., Richards, A. M., Simpson, E. R., & Ellmers, L. J. (2010, November-December). Metabolic syndrome alters cardiorenal expression of metabolic risk loci genes. Verbal presentation at the Medical Sciences Congress: A New Decade of Discovery (MedSciNZ), Queenstown, New Zealand.

Rademaker, M., Charles, C., Melton, I., Richards, M., Frampton, C., Siou, J., … Troughton, R. (2010, November-December). Monitoring of heart failure: Comparison of left atrial pressure with intrathoracic impedance and natriuretic peptide measurements in an experimental model of ovine heart failure. Verbal presentation at the Medical Sciences Congress: A New Decade of Discovery (MedSciNZ), Queenstown, New Zealand.

Faatoese, A., Gillies, M., Robertson, P., Doughty, R., Whalley, G., Richards, M., Troughton, R., Wells, E., Sheerin, I., Pitama, S., & Cameron, V. (2010, November-December). Comparison of rates of diagnosed and undiagnosed cardiovascular disease and its risk factors among Māori and non-Māori communities in New Zealand. Verbal presentation at the Medical Sciences Congress: A New Decade of Discovery (MedSciNZ), Queenstown, New Zealand.

2009

Chapter in Book - Research

Richards, A. M. (2009). What we may expect from biomarkers in heart failure. In E. Braunwald (Ed.), Biomarkers in heart failure: An issue of heart failure clinics (Vol.5-4). (pp. 463-470). Philadelphia, PA: Saunders. doi: 10.1016/j.hfc.2009.04.011

Journal - Research Article

Amir, N. L., Gerber, I. L., Edmond, J. J., Langlands, J. M., Richards, A. M., & Ruygrok, P. N. (2009). Plasma B-type natriuretic peptide levels in cardiac donors. Clinical Transplantation, 23, 174-177. doi: 10.1111/j.1399-0012.2009.00954.x

Molyneux, S. L., Florkowski, C. M., Richards, A. M., Lever, M., Young, J. M., & George, P. M. (2009). Coenzyme Q₁₀: An adjunctive therapy for congestive heart failure? [Viewpoint]. New Zealand Medical Journal, 122(1305). Retrieved from http://journal.nzma.org.nz/journal/122-1305/3855/content.pdf

Prickett, T. C. R., Charles, C. J., Yandle, T. G., Richards, A. M., & Espiner, E. A. (2009). Skeletal contributions to plasma CNP forms: Evidence from regional sampling in growing lambs. Peptides, 30(12), 2343-2347. doi: 10.1016/j.peptides.2009.07.023

Lever, M., George, P. M., Slow, S., Elmslie, J. L., Scott, R. S., Richards, A. M., Fink, J. N., & Chambers, S. T. (2009). Fibrates may cause an abnormal urinary betaine loss which is associated with elevations in plasma homocysteine. Cardiovascular Drugs & Therapy, 23(5), 395-401. doi: 10.1007/s10557-009-6188-1

Scott, N. J. A., Ellmers, L. J., Lainchbury, J. G., Maeda, N., Smithies, O., Richards, A. M., & Cameron, V. A. (2009). Influence of natriuretic peptide receptor-1 on survival and cardiac hypertrophy during development. Biochimica et Biophysica Acta: Molecular Basis of Disease, 1792(12), 1175-1184. doi: 10.1016/j.bbadis.2009.09.009

Chen, Y.-H., Yandle, T. G., Richards, A. M., & Palmer, S. C. (2009). Urotensin II immunoreactivity in the human circulation: Evidence for widespread tissue release. Clinical Chemistry, 55(11), 2040-2048. doi: 10.1373/clinchem.2009.131748

Rademaker, M. T., Charles, C. J., Nicholls, M. G., & Richards, A. M. (2009). Urocortin 2 inhibits furosemide-induced activation of renin and enhances renal function and diuretic responsiveness in experimental heart failure. Circulation: Heart Failure, 2(6), 532-540. doi: 10.1161/CIRCHEARTFAILURE.109.861336

Wright, S. P., Doughty, R. N., Frampton, C. M., Gamble, G. D., Yandle, T. G., & Richards, A. M. (2009). Plasma urocortin 1 in human heart failure. Circulation: Heart Failure, 2(5), 465-471. doi: 10.1161/circheartfailure.108.840207

Palmer, S. C., Yandle, T. G., Nicholls, M. G., Frampton, C. M., & Richards, A. M. (2009). Regional clearance of amino-terminal pro-brain natriuretic peptide from human plasma. European Journal of Heart Failure, 11, 832-839. doi: 10.1093/eurjhf/hfp099

Palmer, S. C., Prickett, T. C. R., Espiner, E. A., Yandle, T. G., & Richards, A. M. (2009). Regional release and clearance of C-type natriuretic peptides in the human circulation and relation to cardiac function. Hypertension, 54(3), 612-618. doi: 10.1161/HYPERTENSIONAHA.109.135608

Palmer, B. R., Devereaux, C. L., Dhamrait, S. S., Mocatta, T. J., Pilbrow, A. P., Frampton, C. M., Skelton, L., Yandle, T. G., Winterbourn, C. C., Richards, A. M., … Cameron, V. A. (2009). The common G-866A polymorphism of the UCP2 gene and survival in diabetic patients following myocardial infarction. Cardiovascular Diabetology, 8. doi: 10.1186/1475-2840-8-31

Palmer, S. C., Yandle, T. G., Frampton, C. M., Troughton, R. W., Nicholls, M. G., & Richards, A. M. (2009). Renal and cardiac function for long-term (10 year) risk stratification after myocardial infarction. European Heart Journal, 30, 1486-1494. doi: 10.1093/eurheartj/ehp132

Prosser, H. C. G., Forster, M. E., Richards, A. M., & Pemberton, C. J. (2009). Cardiac chymase converts rat proAngiotensin-12 (PA12) to angiotensin II: Effects of PA12 upon cardiac haemodynamics. Cardiovascular Research, 82(1), 40-50. doi: 10.1093/cvr/cvp003

Troughton, R. W., & Richards, A. M. (2009). B-type natriuretic peptides and echocardiographic measures of cardiac structure and function. JACC: Cardiovascular Imaging, 2(2), 216-225. doi: 10.1016/j.jcmg.2008.12.006

Palmer, S. C., Endre, Z. H., Richards, A. M., & Yandle, T. G. (2009). Characterization of NT-proBNP in human urine. Clinical Chemistry, 55(6), 1126-1134. doi: 10.1373/clinchem.2008.121673

Journal - Research Other

Florkowski, C., Molyneux, S., George, P., Lever, M., & Richards, M. (2009). N-3 polyunsaturated fatty acids and statins in heart failure [Letter]. Lancet, 373(9661), 379-380. doi: 10.1016/S0140-6736(09)60129-X

Journal - Professional & Other Non-Research Articles

Richards, A. M. (2009). Therapeutic potential of infused cardiac natriuretic peptides in myocardial infarction [Editorial]. Heart, 95(16), 1299-1300. doi: 10.1136/hrt.2008.163857

Palmer, S. C., & Richards, A. M. (2009). Does renal clearance differ between the B-type natriuretic peptides (BNP versus NT-proBNP)? [Editorial comment]. JACC, 53(10), 891-892. doi: 10.1016/j.jacc.2008.11.031

Conference Contribution - Published proceedings: Abstract

Cameron, V. A., Pilbrow, A. P., Palmer, B. R., Ellis, K. L., Pearson, J., Moravec, C. S., … Troughton, R. W., & Richards, A. M. (2009). Gene polymorphisms in patients with heart failure and acute coronary syndromes. CVD Prevention and Control. 4(Suppl. 1), (pp. S15). [Abstract]

Charles, C. J., Jardine, D. L., Rademaker, M. T., & Richards, A. M. (2009). Sympathoinhibitory actions of the urocortin peptides suggest therapeutic potential in acute cardiac injury. Clinical Autonomic Research. 19(5), (pp. 284). doi: 10.1007/s10286-009-0030-5

Cameron, V., Faatoese, A., Robertson, P., Gillies, M., Wells, E., Whalley, G., … Sheerin, I., Richards, M., Troughton, R., & Pitama, S. (2009). Cardiovascular risk factors and achievement of treatment targets in a rural Maori community. Proceedings of the ComBio2009 Conference. [CD-ROM] [Abstract]

Palmer, B. R., Ellis, K. L., Pilbrow, A. P., Skelton, L., Frampton, C. M., Troughton, R. W., Yandle, T. G., … Richards, A. M., & Cameron, V. A. (2009). Genetic polymorphism rs6922269 from the MTHFD1L gene predicts survival in patients after acute coronary syndromes. Proceedings of the ComBio2009 Conference. [CD-ROM] [Abstract]

Marshall, C., Fisher, S., Yandle, T. G., Smyth, D., Elliott, J. M., Blake, J., Richards, A. M., & McClean, D. R. (2009). Trans-cardiac production of Urotensin II in acute and chronic ischaemia. Heart, Lung & Circulation, 18(Suppl. 3), (pp. S127). doi: 10.1016/j.hlc.2009.05.289

Marshall, C. J., Fisher, S., Yandle, T. G., Smyth, D., Elliott, J. M., Blake, J., Richards, A. M., & McClean, D. R. (2009). Trans-cardiac production of Urotensin II in acute and chronic ischaemia. Heart, Lung & Circulation, 18(Suppl. 2), (pp. S23). doi: 10.1016/j.hlc.2009.04.053

Elliott, J. M., Aldous, S., Blake, J., McClean, D., Richards, M., & Smyth, D. (2009). Late stent thrombosis after Xience stent implantation and six months of clopidogrel. Heart, Lung & Circulation, 18(Suppl. 2), (pp. S8). doi: 10.1016/j.hlc.2009.04.019

Ellmers, L., Carter, E., Scott, N. J. A., Richards, A. M., Cameron, V. A., & Rademaker, M. T. (2009). Urocortin 2 treatment reduces genes involved in cardiac remodelling in an ovine model of heart failure. European Heart Journal. 30(Suppl. 1), (pp. 288). doi: 10.1093/eurheartj/ehp416

Ellis, K. L., Pilbrow, A. P., Palmer, B. R., Frampton, C. M., Doughty, R. N., Ellis, C. J., Yandle, T. G., Troughton, R. W., Richards, A. M., & Cameron, V. A. (2009). A common variant at chromosome 9p21.3 is associated with age of onset of coronary disease but not subsequent mortality in coronary disease cohorts. European Heart Journal. 30(Suppl. 1), (pp. 63-64). doi: 10.1093/eurheartj/ehp416

Hart, M., Harris, C., Smyth, D., Elliott, J. M., Richards, M., Blake, J., & Bycroft, C. (2009). Effectiveness of MPatcH on haemostasis and mobilisation following diagnostic and interventional cardiology procedures. Heart, Lung & Circulation, 18(Suppl. 3), (pp. S86). doi: 10.1016/j.hlc.2009.05.193

Harris, C., Hart, M., Smyth, D., Elliott, J. M., Richards, M., Blake, J., & Bycroft, C. (2009). Bleeding events in patients randomised to mobilise 4 or 6 h after Percutaneous Coronary Intervention (PCI). Heart, Lung & Circulation, 18(Suppl. 3), (pp. S85). doi: 10.1016/j.hlc.2009.05.190

Pilbrow, A. P., Pearson, J., Brown, C. M., McNoe, L., Black, M. A., Sweet, W. E., … Troughton, R. W., Richards, A. M., … Cameron, V. A. (2009). Chromosome 6q25.1 and 2q36.3 coronary heart disease risk loci are associated with altered cardiac gene expression profiles in normal heart. Circulation, 120(18, Suppl.), (pp. S564). [Abstract]

Hartmann, O., Landsberg, J., Mueller, C., . . ., Richards, M., & et al (2009). Procalcitonin identifies acute heart failure biomarkers in patients with acute heart failure in need of antibiotic therapy: Observational results from the BACH (Biomarkers in Acute Heart failure) trial. Thorax. 64(Suppl. 4), (pp. A62). doi: 10.1136/thx.2009.127092s

Hart, M., Harris, C., Smyth, D., Elliott, J. M., Richards, M., Blake, J., & Bycroft, C. (2009). Effectiveness of MPatcH on haemostasis and mobilisation following diagnostic and interventional cardiology procedures. Heart, Lung & Circulation, 18(Suppl. 2), (pp. S12-S13). doi: 10.1016/j.hlc.2009.04.029

Harris, C., Hart, M., Smyth, D., Elliott, J. M., Richards, M., Blake, J., & Bycroft, C. (2009). Bleeding events in patients randomised to mobilise 4 or 6 h after Percutaneous Coronary Intervention (PCI). Heart, Lung & Circulation, 18(Suppl. 2), (pp. S12). doi: 10.1016/j.hlc.2009.04.028

Hildebrandt, P., Collinson, P., Doughty, R. N., . . ., & Richards, M. (2009). Age-dependent values of NT-proBNP are superior to a single cut-point for ruling out heart failure. The International Collaborative Study of Natriuretic Peptides in Primary Care (ICON-PC). European Heart Journal, 30(Suppl. 1), (pp. 1024-1025). doi: 10.1093/eurheartj/ehp416

Prickett, T. C., Charles, C. J., Yandle, T. G., Richards, A. M., & Espiner, E. A. (2009). Regional sampling and effects of glucocorticoids: Differential responses in A, B and C-type natriuretic peptides in growing lambs. Proceedings of the Endocrine Society's 91st Annual Meeting. Retrieved from http://www.abstracts2view.com/endo/

Shah, R. V., Richards, A. M., Bayes-Genis, A., Pinto, Y., Lainchbury, J., Ordonez, J., … Januzzi, J. L. (2009). What predicts troponin release in acutely decompensated heart failure? Journal of Cardiac Failure, 15(6, Suppl. 1), (pp. S21). doi: 10.1016/j.cardfail.2009.06.376

Faatoese, A., Wells, E., Pitama, S., Gillies, M., Doughty, R., Troughton, R., Richards, M., & Cameron, V. (2009). Screening for cardiovascular disease in Maori communities: The Community Heart Study. Heart, Lung & Circulation, 18(Suppl. 3), (pp. S198). doi: 10.1016/j.hlc.2009.05.448

Shah, R. V., Richards, A. M., Bayes-Genis, A., Pinto, Y., Lainchbury, J., Ordonez, J., … Januzzi, J. L. (2009). Predictors and ramifications of worsening renal function in acutely destabilized heart failure: Results from the ICON Study. Journal of Cardiac Failure, 15(6, Suppl. 1), (pp. S20-S21). doi: 10.1016/j.cardfail.2009.06.375

Scott, N. J. A., Ellmers, L. J., Raudsepp, S., Simpson, E., Richards, A. M., & Cameron, V. A. (2009). Characterising a novel mouse model of the metabolic syndrome. Heart, Lung & Circulation, 18(Suppl. 3), (pp. S240). doi: 10.1016/j.hlc.2009.05.594

Marshall, C. J., Nallaratnam, M., Mocatta, T., Smyth, D., Richards, M., Elliott, J. M., Blake, J., Winterbourn, C., Kettle, A. J., & McClean, D. R. (2009). Plasma myeloperoxidase at the culprit coronary lesion in acute myocardial infarction. Heart, Lung & Circulation, 18(Suppl. 3), (pp. S119-S120). doi: 10.1016/j.hlc.2009.05.270

Marshall, C. J., Nallaratnam, M., Mocatta, T., Smyth, D., Richards, A. M., Elliott, J. M., Blake, J., Winterbourn, C., Kettle, A. J., & McClean, D. R. (2009). Plasma myeloperoxidase at the culprit coronary lesion in acute myocardial infarction. Heart, Lung & Circulation, 18(Suppl. 2), (pp. S22-S23). doi: 10.1016/j.hlc.2009.04.052

Marshall, C. J., Mocatta, T., McKenzie, J., Kettle, A., Blake, J., Elliott, J., Smyth, D., Richards, M., & McClean, D. R. (2009). Acute systemic and local neutrophil and monocyte degranulation prior to primary percutaneous coronary intervention in ST elevation myocardial infarction. JACC, 53(10, Suppl. 1), (pp. A307-A308). [Abstract]

Conference Contribution - Verbal presentation and other Conference outputs

Richards, M. (2009, September). NT-proBNP is cleared from the circulation by multiple tissues. Verbal presentation at the 7th International Symposium on NT-proBNP, Barcelona, Spain.

Richards, M. (2009, October). Take a step back: Does my patient have heart failure? Do I need an echo? What about BNP? Verbal presentation at the Echo: Echocardiography in Practice Conference, Singapore.

Richards, M. (2009, April). Guiding treatment of heart failure with serial measurements of NT-proBNP: What is the evidence? Verbal presentation at the 6th Oulu Symposium, Sotkamo, Finland.

Richards, M. (2009, April). Treatment titration using biomarkers: Where do we stand? What do we need? Verbal presentation at the Fifth Annual Biomarkers in Heart Disease: What Every Health Care Practitioner Needs to Know Conference, San Diego, CA.

Richards, M. (2009, May). Diagnosis to prognosis: The role of biomarkers for acute coronary syndromes from Emergency Medicine into the community. Verbal presentation at the 17th Asian Pacific Congress of Cardiology, Kyoto, Japan.

Sethi, S., Richards, M., Januzzi, J., Hildebrandt, P., & Hobbs, R. (2009, September). Ask the expert. Panel discussion at the 7th International Symposium on NT-proBNP, Barcelona, Spain.

Film/Video/CD Rom

Fraser, R., Richards, M., Pilbrow, A., & Troughton, R. (2009). The Body, the Research, the Professor: Cardiac Research [Episode 3] [Film]. Christchurch, New Zealand: Canterbury Medical Research Foundation. Retrieved from http://www.cmrf.org.nz/Home/Videos/#vid1

2008

Chapter in Book - Research

Troughton, R. W., & Richards, A. M. (2008). Natriuretic peptides for disease monitoring in patients with chronic heart failure. In J. A. de Lemos (Ed.), Biomarkers in heart disease. (pp. 140-160). Malden, MA: Blackwell.

Nicholls, M. G., & Richards, A. M. (2008). High-risk subgroups: Diabetes and hypertension. In A. Bayés-Genís & J. L. Januzzi (Eds.), NT-proBNP as a biomarker in cardiovascular diseses. (pp. 173-182). Thomson Reuters.

Troughton, R. W., & Richards, A. M. (2008). Outpatient monitoring and treatment of chronic heart failure guided by NT-proBNP measurement. In A. Bayés-Genís & J. L. Januzzi (Eds.), NT-proBNP as a biomarker in cardiovascular diseases. (pp. 91-100). Thomson Reuters.

Journal - Research Article

Baggish, A. L., Lloyd-Jones, D. M., Blatt, J., Richards, A. M., Lainchbury, J., O'Donoghue, M., … Januzzi, J. L. (2008). A clinical and biochemical score for mortality prediction in patients with acute dyspnoea: Derivation, validation and incorporation into a bedside programme. Heart, 94, 1032-1037. doi: 10.1136/hrt.2007.128132

Stewart, R. A., Kerr, A. J., Cowan, B. R., Young, A. A., Occleshaw, C., Richards, A. M., … Whalley, G. A., … for the ZEST Study Investigators. (2008). A randomized trial of the aldosterone-receptor antagonist eplerenone in asymptomatic moderate-severe aortic stenosis. American Heart Journal, 156, 348-355. doi: 10.1016/j.ahj.2008.03.012

Palmer, B. R., Pilbrow, A. P., Frampton, C. M., Yandle, T. G., Skelton, L., Nicholls, M. G., & Richards, A. M. (2008). Plasma aldosterone levels during hospitalization are predictive of survival post-myocardial infarction. European Heart Journal, 29, 2489-2496. doi: 10.1093/eurheartj/ehn383

The ONTARGET Investigators, including Richards, A. M., & Troughton, R. W. (2008). Telmisartan, Ramipral, or both in patients at high risk for vascular events. New England Journal of Medicine, 358(15), 1547-1559.

Rademaker, M. T., Charles, C. J., Nicholls, M. G., & Richards, A. M. (2008). Hemodynamic, hormonal, and renal actions of adrenomedullin 2 in experimental heart failure. Circulation: Heart Failure, 1, 134-142. doi: 10.1161/circheartfailure.107.755504

Pilbrow, A. P., Ellmers, L. J., Black, M. A., Moravec, C. S., Sweet, W. E., Troughton, R. W., Richards, A. M., Frampton, C. M., & Cameron, V. A. (2008). Genomic selection of reference genes for real-time PCR in human myocardium. BMC Medical Genomics, 1, 64. doi: 10.1186/1755-8794-1-64

Prosser, H. C. G., Forster, M. E., Richards, A. M., & Pemberton, C. J. (2008). Urotensin II and urotensin II-related peptide (URP) in cardiac ischemia-reperfusion injury. Peptides, 29(5), 770-777. doi: 10.1016/j.peptides.2007.08.013

Rademaker, M. T., Charles, C. J., Nicholls, M. G., & Richards, A. M. (2008). Urocortin 2 combined with angiotensin-converting enzyme inhibition in experimental heart failure. Clinical Science, 114(10), 635-642. doi: 10.1042/CS20070364

Charles, C. J., Jardine, D. L., Nicholls, M. G., Rademaker, M. T., & Richards, A. M. (2008). Urocortin 1 exhibits potent inhibition of cardiac sympathetic nerve activity in conscious sheep. Journal of Hypertension, 26(1), 53-60.

Ellmers, L. J., Scott, N. J. A., Medicherla, S., Pilbrow, A. P., Bridgman, P. G., Yandle, T. G., Richards, A. M., … Cameron, V. A. (2008). Transforming growth factor-β blockade down-regulates the renin-angiotensin system and modifies cardiac remodeling after myocardial infarction. Endocrinology, 149(11), 5828-5834. doi: 10.1210/en.2008-0165

Whalley, G. A., Wright, S. P., Pearl, A., Gamble, G. D., Walsh, H. J., Richards, M., & Doughty, R. N. (2008). Prognostic role of echocardiography and brain natriuretic peptide in symptomatic breathless patients in the community. European Heart Journal, 29(4), 509-516. doi: 10.1093/eurheartj/ehm647

Prickett, T. C. R., Dixon, B., Frampton, C., Yandle, T. G., Richards, A. M., Espiner, E. A., & Darlow, B. A. (2008). Plasma amino-terminal pro C-type natriuretic peptide in the neonate: Relation to gestational age and postnatal linear growth. Journal of Clinical Endocrinology & Metabolism, 93(1), 225-232. doi: 10.1210/jc.2007-1815

Ferrier, K. A., Neill, A. M., O'Meeghan, T., Richards, M., & Campbell, A. J. (2008). Continuous positive airway pressure in heart failure patients with obstructive sleep apnoea. Internal Medicine Journal, 38(11), 829-836. doi: 10.1111/j.1445-5994.2007.01585.x

Littlejohn, M. D., Palmer, B. R., Richards, A. M., Frampton, C. M., Pilbrow, A. P., Troughton, R. W., Cameron, V. A., & Kennedy, M. A. (2008). Ile164 variant of β2-adrenoceptor does not influence outcome in heart failure but may interact with β blocker treatment. European Journal of Heart Failure, 10(1), 55-59. doi: 10.1016/j.ejheart.2007.10.011

Prickett, T. C. R., Barrell, G. K., Wellby, M., Yandle, T. G., Richards, A. M., & Espiner, E. A. (2008). Effect of sex steroids on plasma C-type natriuretic peptide forms: Stimulation by oestradiol in lambs and adult sheep. Journal of Endocrinology, 199(3), 481-487. doi: 10.1677/JOE-08-0267

Hillock, R. J., Frampton, C. M., Yandle, T. G., Troughton, R. W., Lainchbury, J. G., & Richards, A. M. (2008). B-type natriuretic peptide infusions in acute myocardial infarction. Heart, 94(5), 617-622. doi: 10.1136/hrt.2006.110239

Piuhola, J., Kerkelä, R., Keenan, J. I., Hampton, M. B., Richards, A. M., & Pemberton, C. J. (2008). Direct cardiac actions of erythropoietin (EPO): Effects on cardiac contractility, BNP secretion and ischaemia/reperfusion injury. Clinical Science, 114(4), 293-304. doi: 10.1042/CS20070229

Molyneux, S. L., Florkowski, C. M., George, P. M., Pilbrow, A. P., Frampton, C. M., Lever, M., & Richards, A. M. (2008). Coenzyme Q₁₀: An independent predictor of mortality in chronic heart failure. JACC, 52(18), 1435-1441. doi: 10.1016/j.jacc.2008.07.044

Palmer, B. R., Jarvis, M. D., Pilbrow, A. P., Ellis, K. L., Frampton, C. M., Skelton, L., Yandle, T. G., … Whalley, G. A., … Troughton, R. W., Richards, A. M., & Cameron, V. A. (2008). Angiotensin-converting enzyme 2 A1075G polymorphism is associated with survival in an acute coronary syndromes cohort. American Heart Journal, 156(4), 752-758. doi: 10.1016/j.ahj.2008.06.013

Peebles, K. C., Richards, A. M., Celi, L., McGrattan, K., Murrell, C. J., & Ainslie, P. N. (2008). Human cerebral arteriovenous vasoactive exchange during alterations in arterial blood gases. Journal of Applied Physiology, 105(4), 1060-1068. doi: 10.1152/japplphysiol.90613.2008

Pemberton, C. J., & Richards, A. M. (2008). Biochemistry of ghrelin precursor peptides. Vitamins & Hormones, 77, 13-30. doi: 10.1016/S0083-6729(06)77002-9

Journal - Research Other

Richards, A. M. (2008). Serial measurements of plasma B-type natriuretic peptides: What do they tell us? [Editiorial comment]. JACC, 52(12), 1004-1005. doi: 10.1016/j.jacc.2008.06.026

Journal - Professional & Other Non-Research Articles

Januzzi, Jr, J. L., & Richards, A. M. (2008). An International Consensus Statement regarding amino-terminal pro-B-type natriuretic peptide testing: The International NT-proBNP Consensus Panel [Introduction]. American Journal of Cardiology, 101(3A), 1A-2A.

Conference Contribution - Published proceedings: Full paper

Hildebrandt, P., & Richards, A. M. (2008). Amino-terminal pro-B-type natriuretic peptide testing in patients with diabetes mellitus and with systemic hypertension. American Journal of Cardiology. 101(Suppl. 3A), (pp. 21A-24A). [Full Paper]

Troughton, R. W., & Richards, A. M. (2008). Outpatient monitoring and treatment of chronic heart failure guided by amino-terminal pro—B-type natriuretic peptide measurement. American Journal of Cardiology. 101(3, Suppl.1), (pp. 72A-75A). doi: 10.1016/j.amjcard.2007.11.027

Martinez-Rumayor, A., Richards, A. M., Burnett, J. C., & Januzzi, Jr, J. L. (2008). Biology of the natriuretic peptides. American Journal of Cardiology. 101(3, Suppl. 1), (pp. 3A-8A). doi: 10.1016/j.amjcard.2007.11.012

Conference Contribution - Published proceedings: Abstract

Palmer, B. R., Jarvis, M. D., Pilbrow, A. P., Frampton, C. M., Skelton, L., Littlejohn, M. D., Kennedy, M. A., … Yandle, T. G., Richards, A. M., & Cameron, V. A. (2008). Cardiovascular pharmacogenetics: Taking the opportunities. Proceedings of the 4th Annual Carney Pharmacogenomics Symposium. Retrieved from http://www.chmeds.ac.nz/research/carneycentre/symposium.htm

Charles, C. J., Jardine, D. L., Rademaker, M. T., & Richards, A. M. (2008). Sympathoinhibitory actions of the urocortins suggest therapeutic potential in acute cardiac injury. Proceedings of the 2nd Cardiovascular Control Conference. CCC. Retrieved from http://cccindia08.florey.edu.au/India08%20Abstracts.pdf

Park, R. E., Ritzema, J. L. T., Melton, I. C., Crozier, I. G., Richards, A. M., & Troughton, R. W. (2008). Comparison of intrathoracic impedance with direct left atrial pressure in chronic heart failure. Heart, Lung & Circulation, 17(3, Suppl.), (pp. S72). doi: 10.1016/j.hlc.2008.05.169

Anker, S. D., Peacock, F., Mueller, C., Nowak, R., Anand, I., Christensen, R., … Richards, M., … Maisel, A. (2008). Midregional pro-Adrenomedullin (proADM) vs BNP and NTproBNP as prognosticator in heart failure patients: Results of the BACH Multinational Trial. Circulation, 118(22), (pp. 2312-2313). [Abstract]

Scott, N. J. A., Ellmers, L. J., Richards, A. M., Cameron, V. A., Lainchbury, J. G., Maeda, N., & Smithies, O. (2008). Natriuretic peptide signaling has distinct roles in cardiac development and cardiac remodeling in the NPR1-/-mouse. Arquivos Brasileiros de Endocrinologia & Metabologia. 52(Suppl. 6 (Parte II)), (pp. S962). [Abstract]

Stewart, R. A. H., Kerr, A., Legget, M. E., Richards, M., Whalley, G., Friedlander, D., … Williams, M., Simmonds, M., … Lainchbury, J., … White, H. D. (2008). N-terminal pro-B-type natriuretic peptide in aortic stenosis: Results from the NZ Heart Valve Study. Heart, Lung & Circulation, 17(Suppl. 2), (pp. S9-S10). doi: 10.1016/j.hlc.2008.03.019

Siriwardena, M., Pilbrow, A., Richards, A. M., & Wilkins, G. T. (2008). Intra-aortic balloon counter-pulsation use at two tertiary referral centres in the South Island. Heart, Lung & Circulation, 17(Suppl. 2), (pp. S25-S26). doi: 10.1016/j.hlc.2008.03.059

Siriwardena, M., Nicholls, M. G., Yandle, T. G., Frampton, C. M., Richards, A. M., & Pemberton, C. J. (2008). Immunoreactive BNP-signal peptide: A potential early biomarker of AMI. Heart, Lung & Circulation, 17(Suppl. 3), (pp. S104). doi: 10.1016/j.hlc.2008.05.250

Richards, A. M., Lainchbury, J. G., Troughton, R. W., Strangman, K., Frampton, C. M., Pilbrow, A., Yandle, T. G., Hamid, A., & Nicholls, M. G. (2008). NTproBNP guided treatment for chronic heart failure: Results from the Battlescarred Trial. Circulation, 118(18, Suppl.), (pp. 1035-1036). [Abstract]

Ritzema, J., Richards, M., Crozier, I., Gardiner, N., Melton, I., Doughty, R., … Troughton, R. (2008). Serial Doppler echocardiography and tissue Doppler imaging measurements can accurately detect elevated directly measured left atrial pressure in chronic heart failure. Heart, Lung & Circulation, 17(Suppl. 3), (pp. S36). doi: 10.1016/j.hlc.2008.05.084

Ritzema, J., Richards, M., Crozier, I., Gardiner, N., Melton, I., Doughty, R., … Troughton, R. (2008). Serial Doppler echocardiography and tissue Doppler imaging measurements can accurately detect elevated directly measured left atrial pressure in chronic heart failure. Heart, Lung & Circulation, 17(Suppl. 2), (pp. S3). doi: 10.1016/j.hlc.2008.03.004

Drennan, P. G., Troughton, R., Chapman, P. T., O'Donnell, J. L., Richards, A. M., Frampton, C., & Stamp, L. (2008). Determining the association between N terminal pro-brain natriuretic peptide (NT-proBNP) and systemic inflammation in patients with RA. Internal Medicine Journal, 38(Suppl. 2), (pp. A23). doi: 10.1111/j.1445-5994.2008.01691.x

Irvine, J., Pilbrow, A., Frampton, C., Endre, Z., Richards, M., & Cameron, V. (2008). Early post transplant anaemia is not associated with the angiotensin II type 1 A1166C single nucleotide polymorphism or angiotensin converting enzyme insertin/deletion polymorphism in renal transplantation. Transplantation. 86(2S), (pp. 735). [Abstract]

Palmer, B. R., Pilbrow, A. P., Skelton, L., Ellis, K. L., Jarvis, M. D., Frampton, C. M., Yandle, T. G., Richards, A. M., & Cameron, V. A. (2008). ACE gene polymorphisms, survival and natriuretic peptide profiles after acute coronary syndromes. Arquivos Brasileiros de Endocrinologia & Metabologia. (pp. S895-S896). [Abstract]

Palmer, S., Nicholls, G., Frampton, C., & Richards, M. (2008). The combination of plasma NT-proBNP and kidney function improves risk stratification for 10-year outcomes after acute myocardial infarction. Journal of the American Society of Nephrology, 19, (pp. 553A). [Abstract]

Palmer, S., Devarajan, P., Endre, Z., & Richards, M. (2008). Plasma and urine neutrophil gelatinase-associated lipocalin (NGAL) levels are elevated early in acute decompensated heart failure. Nephrology. 13(Suppl. 3), (pp. A131). [Abstract]

Aldous, S., Blake, J., Elliott, J., McClean, D., Richards, M., & Smyth, D. (2008). The real life experience of Everolimus Eluting Coronary Stent: ″The appliance of XIENCE″. Heart, Lung & Circulation, 17(Suppl. 2), (pp. S10). doi: 10.1016/j.hlc.2008.03.021

Marshall, C., Mocatta, T., McKenzie, J., Kettle, A., Blake, J., Elliott, J., Smyth, D., Richards, M., & McClean, D. (2008). Increased systemic and local neutrophil and monocyte degranulation in patients undergoing primary percutaneous coronary intervention for acute ST elevation myocardial infarction. Heart, Lung & Circulation, 17S, (pp. S106). doi: 10.1016/j.hlc.2008.05.255

Campbell, G., Richards, A. M., Frampton, C., & Elliott, J. M. (2008). Treatment of acute myocardial infarction (AMI) in 2006 and one-year outcomes. Heart, Lung & Circulation, 17S, (pp. S34). doi: 10.1016/j.hlc.2008.03.078

Marshall, C., Mocatta, T., McKenzie, J., Kettle, A. J., Blake, J., Elliott, J., Smyth, D., Richards, M., & McClean, D. R. (2008). Increased neutrophil and monocyte degranulation with release of intracellular leucocyte elastase and myeloperoxidase in acute ST elevation myocardial infarction. Heart, Lung & Circulation, 17S, (pp. S2). doi: 10.1016/j.hlc.2008.03.003

Palmer, S., Devarajan, P., Endre, Z., & Richards, M. (2008). Plasma and urine Neutrophil Gelatinase-Associated Lipocalin (NGAL) levels are elevated early in acute decompensated heart failure. Journal of the American Society of Nephrology. 19(Abstract Issue), (pp. 569A). [Abstract]

Irvine, J., Nicholls, G., Richards, M., Frampton, C., Endre, Z., Robinson, J., & Cameron, V. (2008). Vascular responses to incremental angiotensin II infusion in healthy volunteers with AA versus CC angiotensin II type 1 receptor genotypes. Nephrology. 13(Suppl. 3), (pp. A120). [Abstract]

Pilbrow, A., Pearson, J., McNoe, L., Black, M., Moravec, C., Sweet, W., … Troughton, R., Richards, M., & Cameron, V. (2008). The chromosome 9p21.3 coronary artery disease risk locus is associated with altered cardiac gene expression in individuals without overt cardiac abnormality. Circulation, 118(18, Suppl.), (pp. S_390-S_391). [Abstract]

Rademaker, M. T., Charles, C. J., Nicholls, M. G., & Richards, A. M. (2008). Hemodynamic, hormonal and renal actions of adrenomedullin 2 in experimental heart failure. Arquivos Brasileiros de Endocrinologia & Metabologia. 52(Suppl. 6 (Parte II)), (pp. S807-S808). [Abstract]

Irvine, J. H., Pilbrow, A. P., Frampton, C. M., Richards, M. A., Endre, Z. H., & Cameron, V. A. (2008). Donor type and recipient angiotensin II type 1 receptor A1166C genotype may influence kidney transplant survival at 10 years. Journal of the American Society of Nephrology, 19(Abstracts Issue), (pp. 441A-442A). [Abstract]

Pemberton, C. J., Rothwell, S. E., & Richards, A. M. (2008). The novel adipocytokine resistin worsens cardiac ischaemia-reperfusion injury. European Heart Journal. 29(Suppl. 1), (pp. 629). [Abstract]

Ellis, K. L., Pilbrow, A. P., Skelton, L., Frampton, C. M., Yandle, T. G., Palmer, B. R., Gemmell, N. J., Richards, A. M., & Cameron, V. A. (2008). Prognostic neurohormone levels in acute coronary syndromes patients of New Zealand European, Maori and Pacific ancestry. New Zealand Medical Journal, 121(1271). Retrieved from http://journal.nzma.org.nz/journal/121-1271/2990/content.pdf

Palmer, B. R., Jarvis, M. D., Pilbrow, A. P., Ellis, K. L., Frampton, C. M., Skelton, L., Yandle, T. G., … Troughton, R. W., Richards, A. M., & Cameron, V. A. (2008). Angiotensin-converting enzyme 2 gene variants and survival in an acute coronary syndromes cohort. New Zealand Medical Journal, 121(1271). Retrieved from http://journal.nzma.org.nz/journal/121-1271/2990/content.pdf

Charles, C., Jardine, D., Nicholls, G., Rademaker, M., & Richards, M. (2008). Urocortin 2 induces potent long-lasting inhibition of cardiac sympathetic drive despite baroreflex activation in conscious sheep. Heart, Lung & Circulation, 17(Suppl. 1), (pp. S1). doi: 10.1016/j.hlc.2007.11.002

Nallaratnam, M., Mocatta, T., Marshall, C., Smyth, D., Winterbourn, C., Elliott, J., Richards, M., Kettle, A. J., & McClean, D. R. (2008). Local leukocyte elastase release at site of occlusive plaque rupture predicts downstream microvascular reperfusion injury and impaired left ventricular function in ST elevation myocardial infarction. JACC, 1(2 (Suppl. B)), (pp. B64). [Abstract]

Collison, P. O., . . ., & Richards, A. (2008). The second International COllaborative study of N-terminal pro B type natriuretic peptide NTproBNP in Primary care (ICON II-PC). Clinical Chemistry. 54(6, Suppl.), (pp. A95-A96). [Abstract]

Conference Contribution - Verbal presentation and other Conference outputs

Pitama, S., Cameron, V., Huria, T., Gillies, M., Whalley, G., Doughty, R., Richards, M., Faatoese, A., Tikao-Mason, K., & Robertson, P. (2008, September). Hauora Manawa/heart health: The Community Heart Study. Verbal presentation at the Ngā Kete a Rēhua Inaugural Māori Research Symposium Te Waipounamu, Christchurch, New Zealand.

Carter, E., Scott, N. J. A., Richards, A. M., Cameron, V. A., Rademaker, M. T., & Ellmers, L. J. (2008, November). Urocortin 2 treatment reduces genes involved in cardiac remodelling in an ovine model of heart failure. Verbal presentation at the Medical Sciences Congress, Queenstown, New Zealand.

Prosser, H. C. G., Forster, M. E., Richards, A. M., & Pemberton, C. J. (2008, November). Cardiac chymase activity converts proangiotensin-12 (PA12) to angiotensin II: Effects of PA12 upon cardiac haemodynamics. Verbal presentation at the Medical Sciences Congress, Queenstown, New Zealand.

Peebles, K., Richards, M., Celi, L., McGrattan, K., Murrell, C., & Ainslie, P. (2008, November). Changes in cerebral vasoactive factors during acute alterations in arterial blood gases in humans. Verbal presentation at the Medical Sciences Congress, Queenstown, New Zealand.

Piuhola, J., Kerkelä, R., Keenan, J. I., Hampton, M. B., Richards, A. M., & Pemberton, C. (2008, November). Direct cardiac actions of erythropoietin (EPO): Effects on cardiac contractility, BNP secretion and ischemia-reperfusion injury. Verbal presentation at the Medical Sciences Congress, Queenstown, New Zealand.

Richards, A. M., & Januzzi, J. (2008, June). Statement from the International NT-proBNP Consensus Panel. Verbal presentation at the 6th International Symposium on NT-proBNP, Baveno, Italy.

Richards, M. (2008, October). International collaboration of NTproBNP (ICON). Verbal presentation at the New Zealand-Singapore Heart Failure Research Symposium, Christchurch, New Zealand.

Richards, M. (2008, October). Introduction New Zealand. Verbal presentation at the New Zealand-Singapore Heart Failure Research Symposium, Christchurch, New Zealand.

Richards, M. (2008, March). Battle-scarred study. Verbal presentation at the Fourth Annual Biomarkers in Heart Disease Symposium, San Diego, California.

Richards, M. (2008, June). BNP should be used to guide therapy in patients with heart failure: PRO. Verbal presentation at the Heart Failure Congress, Milan, Italy.

Richards, M. (2008, September). Diagnosis and monitoring of heart failure: The role of BNP. Keynote presentation at the Frontiers of Medicine and Surgery Conference, Wellington, New Zealand.

Richards, A. M. (2008, September-October). Clinical applications of B-type natriuretic peptide testing. Verbal presentation at the 20th International Congress of Clinical Chemistry and Laboratory Medicine, Fortaleza, Brazil.

Richards, M. (2008, January-February). Beyond BNP: Novel neurohormonal biomarkers in heart failure. Verbal presentation at the 4th Asian Pacific Congress of Heart Failure, Melbourne, Australia.

Mahagamasekera, M. G. P., Ruygrok, P. N., Palmer, S., Ansell, G., Nicholls, M. G., Pemberton, C. J., Richards, A. M., & Yandle, T. G. (2008, November). B-type natriuretic peptide and its degradation products in the heart and circulation in end-stage heart failure. Verbal presentation at the Medical Sciences Congress, Queenstown, New Zealand.

Charles, C. J., Rademaker, M. T., Nicholls, M. G., & Richards, A. M. (2008, November). Adrenomedullin 2 attenuates the pressor but not adrenal responses to angiotensin II in conscious sheep. Verbal presentation at the Medical Sciences Congress, Queenstown, New Zealand.

Richards, M. (2008, November). Biomarkers in cardiovascular disease. Verbal presentation at the Medical Sciences Congress, Queenstown, New Zealand.

2007

Chapter in Book - Other

Nicholls, M. G., & Richards, A. M. (2007). Endocrine causes of hypertension. In J. Feehally, J. Floege & R. J. Johnson (Eds.), Comprehensive clinical nephrology. (3rd ed.) (pp. 443-452). Philadelphia: Mosby.

Journal - Research Article

Rademaker, M. T., Charles, C. J., & Richards, A. M. (2007). Urocortin 1 administration from onset of rapid left ventricular pacing represses progression to overt heart failure. American Journal of Physiology: Heart & Circulatory Physiology, 293, H1536-H1544. doi: 10.1152/ajpheart.00377.2007

Troughton, R. W., Richards, A. M., Yandle, T. G., Frampton, C. M., & Nicholls, M. G. (2007). The effects of medications on circulating levels of cardiac natriuretic peptides. Annals of Medicine, 39(4), 242-260.

Kemp, W., Krum, H., Colman, J., Bailey, M., Yandle, T., Richards, M., & Roberts, S. (2007). Urotensin II: A novel vasoactive mediator linked to chronic liver disease and portal hypertension. Liver International, 27(9), 1232-1239.

Ritzema, J., Melton, I. C., Richards, A. M., Crozier, I. G., Frampton, C., Doughty, R. N., … Troughton, R. W. (2007). Direct left atrial pressure monitoring in ambulatory heart failure patients: Initial experience with a new permanent implantable device. Circulation, 116(25), 2952-2959.

Bayes-Genis, A., Lloyd-Jones, D. M., van Kimmenade, R. R. J., Lainchbury, J. G., Richards, A. M., Ordonez-Llanos, J., … Januzzi, Jr, J. L. (2007). Effect of body mass index on diagnostic and prognostic usefulness of amino-terminal pro-brain natriuretic peptide in patients with acute dyspnea. Archives of Internal Medicine, 167(4), 400-407.

Pilbrow, A. P., Palmer, B. R., Frampton, C. M., Yandle, T. G., Troughton, R. W., Campbell, E., Skelton, L., Lainchbury, J. G., Richards, A. M., & Cameron, V. A. (2007). Angiotensinogen M235T and T174M gene polymorphisms in combination doubles the risk of mortality in heart failure. Hypertension, 49(2), 322-327.

Baggish, A. L., van Kimmenade, R., Bayes-Genis, A., Davis, M., Lainchbury, J. G., Frampton, C., … Richards, M. A., & Januzzi, J. L. (2007). Hemoglobin and N-terminal pro-brain natriuretic peptide: Independent and synergistic predictors of mortality in patients with acute heart failure: Results from the International Collaborative of NT-proBNP (ICON) Study. Clinica Chimica Acta, 381(2), 145-150. doi: 10.1016/j.cca.2007.03.010

Jogia, P. M., Kalkoff, M., Sleigh, J. W., Bertinelli, A., La Pine, M., Richards, A. M., & Devlin, G. (2007). NT-pro BNP secretion and clinical endpoints in cardiac surgery intensive care patients. Anaesthesia & Intensive Care, 35(3), 363-369.

Davis, M. E., Pemberton, C. J., Yandle, T. G., Fisher, S. F., Lainchbury, J. G., Frampton, C. M., Rademaker, M. T., & Richards, M. (2007). Urocortin 2 infusion in human heart failure. European Heart Journal, 28(21), 2589-2597.

Jardine, D. L., Charles, C. J., Frampton, C. M., & Richards, A. M. (2007). Cardiac sympathetic nerve activity and ventricular fibrillation during acute myocardial infarction in a conscious sheep model. American Journal of Physiology: Heart & Circulatory Physiology, 293, H433-H439. doi: 10.1152/ajpheart.01262.2006

Davis, M. E., Pemberton, C. J., Yandle, T. G., Fisher, S. F., Lainchbury, J. G., Frampton, C. M., Rademaker, M. T., & Richards, A. M. (2007). Urocortin 2 infusion in healthy humans: Hemodynamic, neurohormonal, and renal responses. JACC, 49(4), 461-471.

Baird, T. E., Palmer, B. R., Frampton, C. M., Yandle, T. G., Skelton, L., Richards, A. M., & Cameron, V. A. (2007). Association of the aldosterone synthase gene C-344T polymorphism with risk factors and survival in a post-myocardial infarction cohort. Journal of Human Hypertension, 21, 256-258.

Charles, C. J., Rademaker, M. T., & Richards, A. M. (2007). Urocortin 1 modulates the neurohumoral response to acute nitroprusside-induced hypotension in sheep. Clinical Science, 112, 485-491.

Prickett, T. C. R., Barrell, G. K., Wellby, M., Yandle, T. G., Richards, A. M., & Espiner, E. A. (2007). Response of plasma CNP forms to acute anabolic and catabolic interventions in growing lambs. American Journal of Physiology: Endocrinology & Metabolism, 292, E1395-E1400. doi: 10.1152/ajpendo.00469.2006

Ellmers, L. J., Scott, N. J. A., Piuhola, J., Maeda, N., Smithies, O., Frampton, C. M., Richards, A. M., & Cameron, V. A. (2007). Npr1-regulated gene pathways contributing to cardiac hypertrophy and fibrosis. Journal of Molecular Endocrinology, 38, 245-257.

Bang, A. S., Soule, S. G., Yandle, T. G., Richards, A. M., & Pemberton, C. J. (2007). Characterisation of proghrelin peptides in mammalian tissue and plasma. Journal of Endocrinology, 192, 313-323.

Mocatta, T. J., Pilbrow, A. P., Cameron, V. A., Senthilmohan, R., Frampton, C. M., Richards, A. M., & Winterbourn, C. C. (2007). Plasma concentrations of myeloperoxidase predict mortality after myocardial infarction. JACC, 49(20), 1993-2000. doi: 10.1016/j.jacc.2007.02.040

Journal - Research Other

Palmer, B. R., Frampton, C. M., Richards, A. M., & Cameron, V. A. (2007). AMPD1 gene polymorphism and survival in patients with stable congestive heart failure [Letter to the editor]. American Heart Journal, 153, e13. Retrieved from http://www.sciencedirect.com/science?_ob=PublicationURL&_tockey=%23TOC%236683%232007%23998469994%23650294%23FLA%23&_cdi=6683&_pubType=J&_auth=y&_acct=C000007718&_version=1&_urlVersion=0&_userid=100241&md5=724a2d0db54e3f555bbfcbe8269e42c5

Nicholls, M. G., & Richards, A. M. (2007). Disease monitoring of patients with chronic heart failure. Heart, 93, 519-523. doi: 10.1136/hrt.2005.078519

Richards, A. M. (2007). Does NT-proBNP testing reduce costs and improve accuracy in the diagnosis of heart failure? [Commentary]. Nature Clinical Practice Cardiovascular Medicine, 4(12), 652-653. doi: 10.1038/ncpcardio1014

Richards, A. M. (2007). Natriuretic peptides: Update on peptide release, bioactivity, and clinical use. Hypertension, 50(1), 25-30. doi: 10.1161/HYPERTENSIONAHA.106.069153

Richards, A. M. (2007). Variability of NT-proBNP levels in heart failure: Implications for clinical application [Editorial]. Heart, 93, 899-900. doi: 10.1136/hrt.2006.110643

Conference Contribution - Published proceedings: Abstract

Charles, C. J., Jardine, D. L., Nicholls, M. G., Rademaker, M. T., & Richards, A. M. (2007). Urocortin 1 inhibits cardiac sympathetic nerve activity in normal conscious sheep. Endocrine Journal. 54(Suppl.), (pp. 194). [Abstract]

Charles, C. J., Jardine, D. L., & Richards, A. M. (2007). Cardiac sympathetic nerve activity and ventricular fibrillation during acute myocardial infarction in ambulent sheep. Journal of Molecular & Cellular Cardiology, 42(6, Suppl. 1), (pp. S8). [Abstract]

Charles, C. J., Jardine, D. L., Rademaker, M. T., & Richards, A. M. (2007). Urocortin 1 exhibits potent inhibition of cardiac sympathetic nerve activity in ambulent sheep. Journal of Molecular & Cellular Cardiology, 42(6, Suppl. 1), (pp. S35). [Abstract]

Charles, C. J., Rademaker, M. T., Yandle, T. G., & Richards, A. M. (2007). Arterio-venous trans-organ sampling in normal and heart failure sheep: Determining the source of circulating hormones. Endocrine Journal. 54(Suppl.), (pp. 80). [Abstract]

Charles, C. J., Jardine, D. L., Nicholls, M. G., Rademaker, M. T., & Richards, A. M. (2007). Urocortin 1 exhibits potent inhibition of cardiac sympathetic nerve activity in ambulant sheep. European Journal of Heart Failure Supplements, 6(Suppl. 1), (pp. 145). doi: 10.1016/S1567-4215(07)60405-6

Ritzema-Carter, J. L. T., Richards, A. M., Nicholls, M. G., Frampton, C., Melton, I., Crozier, I., … Troughton, R. W. (2007). Variation in B-type natriuretic peptide in ambulatory subjects with stable chronic heart failure is associated with variability in directly measured left atrial pressure. European Heart Journal, 28(Suppl. 1), (pp. 303). doi: 10.1093/eurheartj/ehm418

Prosser, H. C. G., Forster, M. E., Richards, A. M., & Pemberton, C. J. (2007). Direct effects of proangiotensin-12 on the isolated rat heart. European Heart Journal. 28(Abstract Suppl.), (pp. 365). [Abstract]

Ellmers, L., Scott, N. J., Protter, A. A., Medicherla, S., Maeda, N., Smithies, O., Richards, A. M., & Cameron, V. A. (2007). The role of TGF-beta 1 in ventricular remodelling during recovery from experimental myocardial infarction. European Heart Journal. 28(Abstract Suppl.), (pp. 435). [Abstract]

Ellis, K. L., Pilbrow, A. P., Skelton, L. Z., Frampton, C. M., Yandle, T. G., Palmer, B. R., Gemmell, N. J., Richards, A. M., & Cameron, V. A. (2007). Prognostic neurohormone levels in acute coronary syndromes patients of New Zealand European, Maori and Pacific ancestry. European Heart Journal. 28(Abstract Suppl.), (pp. 771). [Abstract]

Richards, A. M. (2007). Multimarker strategies. American College of Cardiology 56th Annual Scientific Session. Retrieved from http://www.cardiosource.com/annualmtg/acc07/Lectures.asp?sessiontitle=Biomarkers%20in%20Heart%20Failure&SessionID=79&date=3/26/2007

Charles, C. J., Jardine, D. L., & Richards, A. M. (2007). Cardiac sympathetic nerve activity and ventricular fibrillation during acute myocardial infarction in a conscious sheep model. European Journal of Heart Failure Supplements, 6(Suppl. 1), (pp. 154). doi: 10.1016/S1567-4215(07)60431-7

Nallaratnam, M., Mocatta, T., Kettle, A. J., Smyth, D., Winterbourn, C., Elliott, J., Richards, M., & McClean, D. (2007). Heparin, but not bilvalirudin, liberates endothelial myeloperoxidase in patients with ST Elevation Myocardial Infarction (STEMI). Heart, Lung & Circulation, 16(Suppl. 2), (pp. S24-S25). doi: 10.1016/j.hlc.2007.06.064

Nallaratnam, M., Mocatta, T., Kettle, A. J., Smyth, D., Winterbourn, C., Elliott, J., Richards, M., & McClean, D. (2007). Plasma myeloperoxidase levels are highest in the Infarct-Related Artery (IRA) in patients with ST Elevation MI. Heart, Lung & Circulation, 16(Suppl. 2), (pp. S25). doi: 10.1016/j.hlc.2007.06.065

Stewart, R., Kerr, A., Cowan, B., Whalley, G., Occleshaw, A., Young, A., Richards, M., … for ZEST investigators. (2007). Electrocardiographic left ventricular 'strain' predicts early left ventricular dysfunction in asymptomatic aortic stenosis. Heart, Lung & Circulation, 16(Suppl. 2), (pp. S72). doi: 10.1016/j.hlc.2007.06.185

Ritzema, J., Richards, M., Nicholls, G., Frampton, C., Melton, I., Crozier, I., … Troughton, R. (2007). Variation in B-type natriuretic peptide in ambulatory subjects with stable chronic heart failure is associated with variability in directly measured left atrial pressure. Heart, Lung & Circulation, 16(Suppl. 2), (pp. S21-S22). doi: 10.1016/j.hlc.2007.06.056

Molyneux, S., Florkowski, C., Richards, M., & George, P. (2007). Plasma Coenzyme Q₁₀ (CoQ₁₀) is an independent predictor of survival in Chronic Heart Failure (CHF). Heart, Lung & Circulation, 16(Suppl. 2), (pp. S7). doi: 10.1016/j.hlc.2007.06.019

Mulholland, A., Elliott, J. M., Frampton, C., Smyth, D. W., & Richards, A. M. (2007). Increased in-hospital revascularization after Acute Myocardial Infarction (AMI) is associated with improved long-term survival. Heart, Lung & Circulation, 16(Suppl. 2), (pp. S123). doi: 10.1016/j.hlc.2007.06.313

Conference Contribution - Poster Presentation (not in published proceedings)

Charles, C. J., Jardine, D. L., Rademaker, M. T., & Richards, A. M. (2007, July). Urocortin 1 exhibits potent inhibition of cardiac sympathetic nerve activity in conscious sheep. Poster session presented at the FASEB Summer Research Conferences, Sydney, Australia.

Conference Contribution - Verbal presentation and other Conference outputs

Ellmers, L. J., Scott, N. J. A., Protter, A. A., Medicherla, S., Pilbrow, A. P., Richards, A. M., & Cameron, V. A. (2007, November). Transforming growth factor-beta blockade down-regulates the renin-angiotensin system and modifies cardiac remodelling post-myocardial infarction. Verbal presentation at the Medical Sciences Congress, Queenstown, New Zealand.

Scott, N. J. A., Ellmers, L. J., Lainchbury, J. G., Maeda, N., Smithies, O., Richards, A. M., & Cameron, V. A. (2007, November). Natriuretic peptide signalling has distinct roles in cardiac development and cardiac remodelling in the NPR-1^-/- mouse. Verbal presentation at the Medical Sciences Congress, Queenstown, New Zealand.

Palmer, B. R., Pilbrow, A. P., Baird, T. E., Collins, R. P., Skelton, L. Z., Frampton, C. M., Yandle, T. G., Richards, A. M., & Cameron, V. A. (2007, August). Genetic predictors of survival after acute myocardial infarction. Verbal presentation at the 17th Queenstown Molecular Biology Meeting, Queenstown, New Zealand.

Pilbrow, A. P., Ellmers, L. J., Black, M., Sweet, W. E., Moravec, C. S., Troughton, R. W., Richards, A. M., & Cameron, V. A. (2007, November). Multiple reference genes are required for accurate normalisation of gene expression levels in human heart. Verbal presentation at the Medical Sciences Congress, Queenstown, New Zealand.

Charles, C. J., Jardine, D. L., Nicholls, M. G., Rademaker, M. T., & Richards, A. M. (2007, November). Urocortin 2 induces potent long-lasting inhibition of cardiac sympathetic drive despite baroreflex activation in conscious sheep. Verbal presentation at the Medical Sciences Congress, Queenstown, New Zealand.

Cameron, V. A., Pilbrow, A. P., Ellis, K. L., Jarvis, M. D., Palmer, B. R., Ellmers, L. J., Scott, N. J. A., Frampton, C. M., Troughton, R. W., & Richards, A. M. (2007, November). Big hearts, bad hearts: Deconstructing the distinction. Verbal presentation at the Medical Sciences Congress, Queenstown, New Zealand.

Palmer, B. R., Jarvis, M. D., Pilbrow, A. P., Ellis, K. L., Frampton, C. M., Skelton, L., Yandle, T. G., … Troughton, R. W., Richards, A. M., & Cameron, V. A. (2007, August). Angiotensin-converting enzyme 2 gene variants and survival in an acute coronary syndromes cohort. Verbal presentation at the Canterbury Health Research Conference, Christchurch, New Zealand.

Pilbrow, A. P., Palmer, B. R., Frampton, C. M., Yandle, T. G., Troughton, R. W., Lainchbury, J. G., Richards, A. M., & Cameron, V. A. (2007, June). Angiotensinogen and angiotensin II Type I receptor gene polymorphisms interact to predict prognosis in heart failure patients. Verbal presentation at the Endocrine Society's 89th Annual Meeting, Toronto, Canada.

Ellis, K. L., Pilbrow, A. P., Skelton, L., Frampton, C. M., Yandle, T. G., Palmer, B. R., Gemmell, N. J., Richards, A. M., & Cameron, V. A. (2007, August). Prognostic neurohormone levels in acute coronary syndromes patients of New Zealand European, Maori and Pacific ancestry. Verbal presentation at the Canterbury Health Research Conference, Christchurch, New Zealand.

Ellis, K. L., Pilbrow, A. P., Skelton, L. Z., Frampton, C. M., Yandle, T. G., Palmer, B. R., Gemmell, N. J., Richards, A. M., & Cameron, V. A. (2007, September). Prognostic neurohormone levels in acute coronary syndromes patients of New Zealand European, Maori and Pacific ancestry. Verbal presentation at the European Society of Cardiology Congress, Vienna, Austria.

Richards, M. (2007, September). International NT-proBNP consensus panel: NT-proBNP for the prognosis and therapy management of patients with heart failure. Verbal presentation at the European Society of Cardiology Congress, Vienna, Austria.

Richards, M. (2007, September). Using BNP to tailor therapy. Verbal presentation at the European Society of Cardiology Congress, Vienna, Austria.

Richards, M. (2007, June). Natriuretic peptides in non-cardiac disease: What is the evidence? Verbal presentation at the Annual Congress of the Heart Failure Association of the European Society of Cardiology, Hamburg, Germany.

Richards, A. M. (2007, June). Urocortins in cardiovascular health ^& disease. Verbal presentation at the Endocrine Society's 89th Annual Meeting, Toronto, Canada.

Richards, A. M. (2007, May). In- and out-hospital management of CHF patients. Verbal presentation at the 5th International Symposium on NT-proBNP, Seville, Spain.

Richards, M. (2007, March). Role of biomarkers for therapy decisions and monitoring of heart failure. Verbal presentation at the 1st International Congress of Cardiomyopathies and Heart Failure, Kyoto, Japan.

Other Research Output

Richards, M. (2007, May). The importance of having a good-humoured heart. Yong Loo Lin School of Medicine, Singapore. [Public Seminar].

2006

Journal - Research Article

Ritzema-Carter, J. L. T., Smyth, D., Troughton, R. W., Crozier, I. G., Melton, I. C., Richards, A. M., … Abraham, W. T. (2006). Dynamic myocardial ischemia caused by circumflex artery stenosis detected by a new implantable left atrial pressure monitoring device. Circulation, 113(15), e705-e706.

Januzzi, J. L., van Kimmenade, R., Lainchbury, J., Bayes-Genis, A., Ordonez-Llanos, J., Santalo-Bel, M., … Richards, M. (2006). NT-proBNP testing for diagnosis and short-term prognosis in acute destabilized heart failure: An international pooled analysis of 1256 patients: The international collaborative of NT-proBNP study. European Heart Journal, 27(3), 330-337.

Richards, M., Nicholls, M. G., Espiner, E. A., Lainchbury, J. G., Troughton, R. W., Elliott, J., Frampton, C. M., Crozier, I. G., Yandle, T. G., … for the Christchurch Cardioendocrine Research Group and the Australia-New Zealand Heart Failure Group. (2006). Comparison of B-type natriuretic peptides for assessment of cardiac function and prognosis in stable ischemic heart disease. JACC, 47(1), 52-60. doi: 10.1016/j.jacc.2005.06.085

Lainchbury, J. G., Troughton, R. W., Frampton, C. M., Yandle, T. G., Hamid, A., Nicholls, M. G., & Richards, A. M. (2006). NTproBNP-guided drug treatment for chronic heart failure: Design and methods in the ″BATTLESCARRED″ trial. European Journal of Heart Failure, 8(5), 532-538.

Baggish, A. L., Siebert, U., Lainchbury, J. G., Cameron, R., Anwaruddin, S., Chen, A., … Richards, A. M., & Januzzi, Jr, J. L. (2006). A validated clinical and biochemical score for the diagnosis of acute heart failure: The ProBNP investigation of dyspnea in the emergency department (PRIDE) acute heart failure score. American Heart Journal, 151(1), 48-54.

van Kimmenade, R. R. J., Januzzi, Jr, J. L., Baggish, A. L., Lainchbury, J. G., Bayes-Genis, A., Richards, A. M., & Pinto, Y. M. (2006). Amino-terminal pro-brain natriuretic peptide, renal function, and outcomes in acute heart failure: Redefining the cardiorenal interaction? JACC, 48(8), 1621-1627.

Davis, M. E., Richards, A. M., Nicholls, M. G., Yandle, T. G., Frampton, C. M., & Troughton, R. W. (2006). Introduction of metoprolol increases plasma B-type cardiac natriuretic peptides in mild, stable heart failure. Circulation, 113(7), 977-985.

van Kimmenade, R. R. J., Pinto, Y. M., Bayes-Genis, A., Lainchbury, J. G., Richards, A. M., & Januzzi, Jr, J. L. (2006). Usefulness of intermediate amino-terminal pro-brain natriuretic peptide concentrations for diagnosis and prognosis of acute heart failure. American Journal of Cardiology, 98(3), 386-390.

Wasywich, C. A., Webster, M. W. I., Richards, A. M., & Stewart, R. A. H. (2006). Coronary sinus and ascending aortic levels of aldosterone, angiotensin II, and B-type natriuretic peptide in patients with aortic stenosis and in patients with coronary heart disease. American Journal of Cardiology, 97(7), 1068-1072.

Strey, C. H., Young, J. M., Lainchbury, J. G., Frampton, C. M., Nicholls, M. G., Richards, A. M., & Scott, R. S. (2006). Short-term statin treatment improves endothelial function and neurohormonal imbalance in normocholesterolaemic patients with non-ischaemic heart failure. Heart, 92(11), 1603-1609. doi: 10.1136/hrt.2005.082560

Collins, R. P., Palmer, B. R., Pilbrow, A. P., Frampton, C. M., Troughton, R. W., Yandle, T. G., Skelton, L., Richards, A. M., & Cameron, V. A. (2006). Evaluation of AMPD1 C34T genotype as a predictor of mortality in heart failure and post-myocardial infarction patients. American Heart Journal, 152(2), 312-320.

Troughton, R. W., Richards, A. M., for the Christchurch Cardioendocrine Research Group. (2006). BNP for clinical monitoring of heart failure. Heart Failure Clinics, 2(3), 333-343.

Rademaker, M. T., Cameron, V. A., Charles, C. J., & Richards, A. M. (2006). Urocortin 3: Haemodynamic, hormonal, and renal effects in expermental heart failure. European Heart Journal, 27(17), 2088-2098.

Charles, C. J., Rademaker, M. T., Richards, A. M., & Yandle, T. G. (2006). Plasma urocortin 1 in sheep: Regional sampling and effects of experimental heart failure. Peptides, 27, 1801-1805.

Charles, C. J., Rademaker, M. T., & Richards, A. M. (2006). Apelin-13 induces a biphasic haemodynamic response and hormonal activation in normal conscious sheep. Journal of Endocrinology, 189(3), 701-710.

Charles, C. J., Rademaker, M. T., & Richards, A. M. (2006). Hemodynamic, hormonal, and renal actions of adrenomedullin-2 in normal conscious sheep. Endocrinology, 147(4), 1871-1877.

Prosser, H. C. G., Leprince, J., Vaudry, H., Richards, A. M., Forster, M. E., & Pemberton, C. J. (2006). Cardiovascular effects of native and non-native urotensin II and urotensin II-related peptide on rat and salmon hearts. Peptides, 27, 3261-3268.

Rothwell, S. E., Richards, A. M., & Pemberton, C. J. (2006). Resistin worsens cardiac ischaemia-reperfusion injury. Biochemical & Biophysical Research Communications, 349, 400-407.

Cameron, V. A., Mocatta, T. J., Pilbrow, A. P., Frampton, C. M., Troughton, R. W., Richards, A. M., & Winterbourn, C. C. (2006). Angiotensin type-1 receptor A1166C gene polymorphism correlates with oxidative stress levels in human heart failure. Hypertension, 47(6), 1155-1161.

Jarvis, M. D., Rademaker, M. T., Ellmers, L. J., Currie, M. J., McKenzie, J. L., Palmer, B. R., Frampton, C. M., Richards, A. M., & Cameron, V. A. (2006). Comparison of infarct-derived and control ovine cardiac myofibroblasts in culture: Response to cytokines and natriuretic peptide receptor expression profiles. American Journal of Physiology: Heart & Circulatory Physiology, 291, H1952-H1958. doi: 10.1152/ajpheart.00764.2005

Charles, C. J., Prickett, T. C. R., Espiner, E. A., Rademaker, M. T., Richards, A. M., & Yandle, T. G. (2006). Regional sampling and the effects of experimental heart failure in sheep: Differential responses in A, B and C-type natriuretic peptides. Peptides, 27(1), 62-68. doi: 10.1016/j.peptides.2005.06.019

Journal - Research Other

Rademaker, M. T., Cameron, V. A., Charles, C. J., & Richards, A. M. (2006). [Response to the letter regarding Article by Rademaker et al, ″Integrated hemodynamic, hormonal, and renal actions of Urocortin 2 in normal and paced sheep: Beneficial effects in heart failure″]. Circulation, 113. Retrieved from http://www.circ.ahajournals.org/cgi/content/full/113/15/e710

Conference Contribution - Published proceedings: Abstract

Scott, N. J. A., Ellmers, L. J., Lainchbury, J., Maeda, N., Smithies, O., Richards, A. M., & Cameron, V. A. (2006). Getting to the heart of it: The role of the natriuretic peptides in cardiac development. Proceedings of the New Zealand Society of Endocrinology Annual Meeting. NZSE. Retrieved from http://nzse.rsnz.org/NZSE%20Abstracts%202006.pdf

Prickett, T. C. R., Lynn, A. M., Wellby, M., Barrell, G. K., Darlow, B. A., Espiner, E. A., Richards, A. M., & Yandle, T. G. (2006). Amino-terminal proCNP: A putative marker of growthplate activity in post natal growth. New Zealand Medical Journal, 119(1231). Retrieved from http://journal.nzma.org.nz/journal/119-1231/1922/content.pdf

Charles, C. J., Jardine, D. L., Nicholls, M. G., & Richards, A. M. (2006). Adrenomedullin increases cardiac sympathetic nerve activity in normal conscious sheep. New Zealand Medical Journal, 119(1231). Retrieved from http://journal.nzma.org.nz/journal/119-1231/1922/content.pdf

Palmer, B. R., Robinson, J., Skelton, L., Frampton, C. M., Pilbrow, A. P., Troughton, R. W., Yandle, T. G., Richards, M., & Cameron, V. A. (2006). The Christchurch Cardioendocrine Research Group DNA Bank: Seeking improved prognostic markers for heart disease patients. Proceedings of the Australian Health and Medical Research Congress. (pp. 389). Sydney, Australia: Australian Health and Medical Research Congress. [Abstract]

Davis, M. E., Pemberton, C. J., Yandle, T. G., Fisher, S. F., Lainchbury, J. G., Frampton, C. M., Rademaker, M. T., Richards, A. M., on behalf of Christchurch Cardioendocrine Research Group. (2006). Urocortin 2 infusion in humans with mild heart failure: Haemodynamics, neurohormonal and renal responses. European Heart Journal, 27(Suppl. 1), (pp. 488). [Abstract]

Ellmers, L. J., Scott, N. J. A., Protter, A. A., Medicherla, S., Maeda, N., Smithies, O., Richards, A. M., & Cameron, V. A. (2006). The role of TGF-β in ventricular remodelling during recovery from experimental myocardial infarction. Proceedings of the New Zealand Society of Endocrinology Annual Meeting. NZSE. Retrieved from http://nzse.rsnz.org/NZSE%20Abstracts%202006.pdf

Cameron, V. A., Pilbrow, A. P., Palmer, B. R., Mocatta, T. J., Frampton, C. M., Troughton, R. W., Richards, A. M., & Winterbourn, C. C. (2006). Oxidative stress levels in human heart disease are correlated with angiotensin type-1 receptor A1166C gene polymorphism. Proceedings of the New Zealand Society of Endocrinology Annual Meeting. NZSE. Retrieved from http://nzse.rsnz.org/NZSE%20Abstracts%202006.pdf

Baggish, A. L., van Kimmenade, R., Bayes-Genis, A., Davis, M., Lainchbury, J. G., Frampton, C., … Richards, A. M., & Januzzi, J. L. (2006). Hemoglobin and N-Terminal Pro-brain Natriuretic Peptide: Independent and synergistic predictors of mortality in patients with acute heart failure. JACC, 47, (pp. 89A). [Abstract]

van Kimmenade, R. R., Januzzi, Jr, J. L., Baggish, A., Lainchbury, J., Bayes-Genis, A., Richards, A. M., & Pinto, Y. M. (2006). NT-proBNP should be used in the definition of the ″cardio-renal syndrome″. Clinical Science. (pp. II-487). [Abstract]

Baggish, A. L., Lloyd-Jones, D. M., O'Donoghue, M., Sakhuja, R., Lainchbury, J. G., Richards, A. M., & Januzzi, J. L. (2006). A validated clinical and biochemical risk score for prediction of one-year mortality in dyspneic emergency department patients: The ProBNP investigation of dyspnea in the Emergency Department (PRIDE) mortality risk score. Clinical Science. (pp. II-529). [Abstract]

van Kimmenade, R. R., Pinto, Y. M., Lainchbury, J. G., Bayes-Genis, A., Richards, M. A., & Januzzi, Jr, J. L. (2006). There is nothing grey about it: Dyspnea with intermediate aminoterminal Pro-B type natriuretic peptide concentrations. JACC, 47, (pp. 67A). [Abstract]

Davis, M. E., Pemberton, C. J., Yandle, T. G., Lainchbury, J. G., Frampton, C. M., Rademaker, M. T., & Richards, M. (2006). Urocortin 2 infusion in healthy humans induces marked hemodynamic, neurohormonal, and renal responses. Journal of the American College of Cardiology. 47(4, Suppl. A), (pp. 310A). [Abstract]

Baggish, A. L., Richards, A. M., van Kimmenade, R. R., Bayes-Genis, A., Lainchbury, J., Pinto, Y., & Januzzi, Jr, J. L. (2006). Amino-terminal pro-Brain Natriuretic Peptide testing is superior to New York Heart Association classification for prediction of one-year mortality in patients with acute heart failure: Results from the international collaborative of NT-proBNP study. Circulation, 114(18, Suppl. II), (pp. 720). [Abstract]

Ritzema, J., Melton, I., Crozier, I., Eigler, N., Whiting, J., Doughty, R., … Richards, M., & Troughton, R. (2006). Direct left atrial pressure monitoring with a novel implantable device in ambulant patients with heart failure: Daily variation and the effect of posture. Heart, Lung & Circulation, 15(3), (pp. 212-213). doi: 10.1016/j.hlc.2006.03.008

Ellmers, L. J., Scott, N. J. A., Piuhola, J., Maeda, N., Smithies, O., Frampton, C. M., Richards, A. M., & Cameron, V. A. (2006). Ventricular gene expression changes during the development of cardiac hypertrophy in Npr-1 knockout mice. New Zealand Medical Journal, 119(1231). Retrieved from http://journal.nzma.org.nz/journal/119-1231/1922/content.pdf

Palmer, B. R., Baird, T. E., Collins, R. P., Pilbrow, A. P., Skelton, L., Frampton, C. M., Yandle, T. G., Richards, A. M., & Cameron, V. A. (2006). Genetic polymorphisms as predictors of clinical outcome after acute myocardial infarction. New Zealand Medical Journal, 119(1231). Retrieved from http://journal.nzma.org.nz/journal/119-1231/1922/content.pdf

Pilbrow, A. P., Palmer, B. R., Frampton, C. M., Yandle, T. G., Troughton, R. W., Campbell, E., Skelton, L., Lainchbury, J. G., Richards, A. M., & Cameron, V. A. (2006). Association of angiotensinogen M235T and T174M gene polymorphisms with mortality in heart failure. New Zealand Medical Journal, 119(1231). Retrieved from http://journal.nzma.org.nz/journal/119-1231/1922/content.pdf

Ellis, C. J., Gamble, G. D., Williams, M., Devlin, G., Matsis, P., Elliott, J. M., Mann, S., … Richards, A. M., … for the NZACS Audit Group. (2006). Service provision to Maori compared to non-Maori acute coronary syndrome patients in New Zealand. Heart, Lung & Circulation, 15(3), (pp. 223). doi: 10.1016/j.hlc.2006.03.008

Ellis, C. J., Gamble, G. D., Elliott, J. M., Devlin, G., Matsis, P., Williams, M., Mann, S., … Richards, A. M., … for the NZ ACS Audit Group. (2006). The influence of gender and age on service provision for acute coronary syndrome patients in New Zealand. Heart, Lung & Circulation, 15(3), (pp. 222). doi: 10.1016/j.hlc.2006.03.008

Conference Contribution - Poster Presentation (not in published proceedings)

Ellis, K. L., Palmer, B. R., Pilbrow, A. P., Cameron, V. A., & Richards, A. M. (2006, August-September). Angiotensinogen M235T and T174M gene variants are associated with myocardial infarction and predict mortality in an acute coronary syndromes cohort. Poster session presented at the 16th Annual Queenstown Molecular Biology Meeting, Queenstown, New Zealand.

Pilbrow, A. P., Palmer, B. R., Frampton, C. M., Yandle, T. G., Troughton, R. W., Campbell, E., Skelton, L., Lainchbury, J. G., Richards, A. M., & Cameron, V. A. (2006, August-September). Angiotensinogen M235T and T174M gene polymorphisms in combination doubles the risk of mortality in heart failure. Poster session presented at the 16th Annual Queenstown Molecular Biology Meeting, Queenstown, New Zealand.

Palmer, B., Baird, T. E., Collins, R. P., Pilbrow, A. P., Frampton, C. M., Yandle, T. G., Richards, A. M., & Cameron, V. A. (2006, September). Genetic polymorphisms as predictors of clinical outcome after acute myocardial infarction. Poster session presented at the World Congress of Cardiology, Barcelona, spain.

Conference Contribution - Verbal presentation and other Conference outputs

Cameron, V. A., Palmer, B. R., Pilbrow, A. P., Ellis, K., & Richards, A. M. (2006, August-September). Gattaca revisited: Are heart disease outcomes written in our genes? Verbal presentation at the 16th Annual Queenstown Molecular Biology Meeting, Queenstown, New Zealand.

2005

Journal - Research Article

Ferrier, K., Campbell, A., Yee, B., Richards, M., O'Meeghan, T., Weatherall, M., & Neill, A. M. (2005). Sleep-disordered breathing occurs frequently in stable outpatients with congestive heart failure. Chest, 128(4), 2116-2122.

Prickett, T. C. R., Lynn, A. M., Barrell, G. K., Darlow, B. A., Cameron, V. A., Espiner, E. A., Richards, A. M., & Yandle, T. G. (2005). Amino-terminal proCNP: A putative marker of cartilage activity in postnatal growth. Pediatric Research, 58(2), 334-340.

Charles, C. J., Jardine, D. L., Nicholls, M. G., & Richards, A. M. (2005). Adrenomedullin increases cardiac sympathetic nerve activity in normal conscious sheep. Journal of Endocrinology, 187, 275-281.

Charles, C. J., Rademaker, M. T., Richards, A. M., & Yandle, T. G. (2005). Urotensin II: Evidence for cardiac, hepatic and renal production. Peptides, 26, 2211-2214. doi: 10.1016/j.peptides.2005.03.043

Rademaker, M. T., Charles, C. J., Espiner, E. A., Frampton, C. M., Lainchbury, J. G., & Richards, A. M. (2005). Endogenous urocortins reduce vascular tone and renin-aldosterone / endothelin activity in experimental heart failure. European Heart Journal, 26(19), 2046-2054. doi: 10.1093/eurheartj/ehi227

Rademaker, M. T., Charles, C. J., Espiner, E. A., Frampton, C. M., Lainchbury, J. G., & Richards, A. M. (2005). Four-day urocortin-I administration has sustained beneficial haemodynamic, hormonal, and renal effects in experimental heart failure. European Heart Journal, 26, 2055-2062. doi: 10.1093/eurheartj/ehi351

Rademaker, M. T., Cameron, V. A., Charles, C. J., & Richards, A. M. (2005). Integrated hemodynamic, hormonal, and renal actions of urocortin 2 in normal and paced sheep: Beneficial effects in heart failure. Circulation, 112, 3624-3632. doi: 10.1161/CIRCULATIONAHA.105.561308

Pemberton, C. J., Raudsepp, S. D., Yandle, T. G., Cameron, V. A., & Richards, A. M. (2005). Plasma cardiotrophin-1 is elevated in human hypertension and stimulated by ventricular stretch. Cardiovascular Research, 68(1), 109-117.

Davis, M. E., Pemberton, C. J., Yandle, T. G., Lainchbury, J. G., Rademaker, M. T., Nicholls, M. G., Frampton, C. M., & Richards, A. M. (2005). Effect of urocortin I infusion in humans with stable congestive cardiac failure. Clinical Science, 109(4), 381-388. doi: 10.1042/CS20050079

Rademaker, M. T., & Richards, A. M. (2005). Cardiac natriuretic peptides for cardiac health. Clinical Science, 108, 23-36. doi: 10.1042/CS20040253

Omland, T., Richards, A. M., Wergeland, R., & Vik-Mo, H. (2005). B-type natriuretic peptide and long-term survival in patients with stable coronary artery disease. American Journal of Cardiology, 95, 24-28.

Gerber, I. L., Legget, M. E., West, T. M., Richards, A. M., & Stewart, R. A. H. (2005). Usefulness of serial measurement of N-terminal pro-brain natriuretic peptide plasma levels in asymptomatic patients with aortic stenosis to predict symptomatic deterioration. American Journal of Cardiology, 95, 898-901.

Charles, C. J., Rademaker, M. T., Nicholls, M. G., & Richards, A. M. (2005). Adrenomedullin in heart failure: Potential therapeutic implications. Future Cardiology, 1(2), 235-243.

Richards, A. M., Troughton, R., Lainchbury, J., Doughty, R., & Wright, S. (2005). Guiding and monitoring of heart failure therapy with NT-ProBNP: Concepts and clinical studies. Journal of Cardiac Failure, 11(5, Suppl.), S34-S37.

Journal - Research Other

Richards, M. (2005). Commentary. Evidence-based Cardiovascular Medicine, 9, 324-325.

Elliott, J., & Richards, M. (2005). Heart attacks and unstable angina (acute coronary syndromes) have doubled in New Zealand since 1989: How do we best manage the epidemic? [Editorial]. New Zealand Medical Journal, 118(1223). Retrieved from http://journal.nzma.org.nz/journal/118-1223/1674/content.pdf

Richards, A. M., & Cohn, J. N. (2005). N-terminal pro-brain natriuretic peptide: A powerful biomarker of cardiac disease. Journal of Cardiac Failure, 11(5, Suppl.), S1-S2.

Troughton, R. W., & Richards, M. (2005). B-type natriuretic peptides: Applications for heart failure management in 2005 [Editorial]. Internal Medicine Journal, 35, 377-379.

Richards, A. M., & Frampton, C. M. (2005). N-terminal-pro-B-type natriuretic peptide: Universal marker of cardiovascular risk? [Editorial]. Circulation, 112(1), 9-11.

Conference Contribution - Published proceedings: Full paper

Richards, M., Troughton, R. W., Lainchbury, J. G., Doughty, R. N., & Wright, S. (2005). Health gains by using natriuretic peptides in diagnosis, prognosis and treatment. The Scandinavian Journal of Clinical and Laboratory Investigation. 65, (pp. 129-137). [Full Paper]

Conference Contribution - Published proceedings: Abstract

Prickett, T., Darlow, B., Lynn, A. M., Barrell, G., Cameron, V., Espiner, E., Richards, M., & Yandle, T. (2005). Amino-terminal proCNP (NT-CNP): A putative marker of growth plate activity. Proceedings of the Perinatal Society of Australia and New Zealand 9th Annual Congress. (pp. P129). [Abstract]

Januzzi, Jr, J. L., van Kimmenade, R. R. J., Lainchbury, J., Bayes-Genis, A., Pinto, Y. M., & Richards, A. M. (2005). The value of NT-proBNP for the evaluation of acute CHF: A multicenter, international meta-analysis of 1256 subjects. JACC, 45(Suppl. A), (pp. 140A). [Abstract]

Pilbrow, A. P., Palmer, B. R., Frampton, C. M., Yandle, T. G., Troughton, R. W., Campbell, E., Skelton, L., Lainchbury, J. G., Richards, A. M., & Cameron, V. A. (2005). The genetics of coronary heart disease. Proceedings of the Human Genetics Society of Australasia (NZ Branch) Biennial Scientific Meeting and Annual General Meeting. [Abstract]

Cameron, V. A., Scott, N., Ellmers, L., Lainchbury, J., Maeda, N., Smithies, O., & Richards, M. (2005). The role of natriuretic peptides in cardiac development. FASEB Journal, 19(4), (pp. A788). [Abstract]

Ellmers, L. J., Scott, N. J. A., Piuhola, J., Frampton, C. M., Richards, A. M., & Cameron, V. A. (2005). Gene expression changes during cardiac development and the development of cardiac hypertrophy in NPR-1 knockout mice. Proceedings of the Medical Sciences Congress. (pp. 48). [Abstract]

Cameron, V. A., Pilbrow, A. P., Mocatta, T. J., Palmer, B. R., Frampton, C. M., Troughton, R. W., Richards, A. M., & Winterbourn, C. C. (2005). Elevated oxidative stress levels in heart disease and association with angiotensin receptor genotype. Proceedings of the Medical Sciences Congress. (pp. 39). [Abstract]

Pemberton, C., Raudsepp, S. D., Cameron, V. A., Yandle, T. G., & Richards, A. M. (2005). Cardiotrophin-1: A complex cytokine stimulated by ventricular stretch. European Heart Journal, 26(Suppl. 1), (pp. 66). doi: 10.1093/eurheartj/26.suppl_1.1

Palmer, B. R., Baird, T. E., Collins, R. P., Pilbrow, A. P., Skelton, L., Frampton, C. M., Yandle, T. G., Richards, A. M., & Cameron, V. A. (2005). Genetic polymorphisms as predictors of clinical outcome after acute myocardial infarction. Proceedings of the Canterbury Health Research Conference. (pp. 20). [Abstract]

Palmer, B. R., Baird, T. E., Yandle, T. G., Skelton, L., Richards, A. M., & Cameron, V. A. (2005). The aldosterone synthase gene (CYP11B2) C-344T polymorphism is associated with brain natriuretic peptide level and survival in a post-myocardial infarction cohort. Proceedings of the New Zealand Society for Biochemistry and Molecular Biology and the New Zealand Microbiological Society Annual Conference. (pp. 110). [Abstract]

Pilbrow, A. P., Palmer, B. R., Frampton, C. M., Yandle, T. G., Troughton, R. W., Campbell, E., Skelton, L., Lainchbury, J. G., Richards, A. M., & Cameron, V. A. (2005). Association of angiotensinogen M235T and T174M gene polymorphisms with mortality in heart failure. Proceedings of the Canterbury Health Research Conference. (pp. 23). [Abstract]

Amir, N. L., Gerber, I. L., Ruygrok, P. N., Edmonds, J. J., West, T. M., Langlands, J. M., … Richards, A. M. (2005). Donor plasma brain natriuretic peptide levels may assist in the selection of donors for cardiac transplantation. Heart, Lung & Circulation, 14(1, Suppl.), (pp. S103-S104). doi: 10.1016/j.hlc.2005.04.007

Davis, M. E., Skinner, M. H., Pemberton, C. J., Yandle, T. G., Lainchbury, J. G., Rademaker, M. T., Frampton, C. M., & Richards, A. M. (2005). First report of urocortin 2 infusion in normal humans. Heart, Lung & Circulation, 14(1, Suppl.), (pp. S111-S112). doi: 10.1016/j.hlc.2005.04.007

Troughton, R. W., Tang, W. H. W., Tong, W., Yandle, T. G., Richards, A. M., & Klein, A. L. (2005). Plasma levels of the vasolidator peptide urocortin-1, but not the vasoconstrictor hormone urotensin-2 reflect symptomatic status and severity of diastolic dysfunction in systolic heart failure patients. Circulation, 112(17), (pp. II-725). [Abstract]

Hillock, R., Frampton, C., Yandle, T., Troughton, R., Lainchbury, J., & Richards, A. M. (2005). B-type natriuretic peptide infusion in acute myocardial infarction. Heart, Lung & Circulation, 14(1, Suppl.), (pp. S97-S98). doi: 10.1016/j.hlc.2005.04.007

Hillock, R. J., Frampton, C., Yandle, T., Troughton, R., Lainchbury, J., & Richards, A. M. (2005). B-type natriuretic peptide infusion and renal function. Heart, Lung & Circulation, 14(1, Suppl.), (pp. S98). doi: 10.1016/j.hlc.2005.04.007

Rademaker, M. T., Charles, C. J., Cameron, V. A., & Richards, A. M. (2005). Urocortin 2 has beneficial hemodynamic, endocrine and renal effects in experimental heart failure. The Journal of Heart Disease. 4(1), (pp. 129). [Abstract]

Tang, W. H. W., Troughton, R. W., Nash, P., Bhavnani, S., Francis, G. S., Starling, R. C., Richards, A. M., Yandle, T., & Klein, A. L. (2005). Reduction of natriuretic peptides in obese patients with systolic heart failure is independent of peptide types and echocardiographic indices of myocardial performance: Analysis from ADEPT Neurohormonal Substudy. Proceedings of the Annual Scientific Session of the American College of Cardiology. (pp. 140A). [Abstract]

Conference Contribution - Verbal presentation and other Conference outputs

Charles, C. J., Jardine, D. L., Nicholls, M. G., & Richards, A. M. (2005, October). Adrenomedullin increases cardiac sympathetic nerve activity in normal conscious sheep. Verbal presentation at the 16th International Symposium on the Autonomic Nervous System, Los Cabos, Mexico.

Richards, A. M. (2005, May). Concepts for using NT-proBNP for the monitoring and guiding of heart failure therapy. Verbal presentation at the 3rd International proCardio Symposium, Dresden, Germany.

Richards, M. (2005, June). Optimal use of BNP in heart failure: Value in monitoring and titrating medical therapy. Verbal presentation at the Meeting of the Heart Failure Association of the ESC, Lisbon, Portugal.

2004

Chapter in Book - Research

Nicholls, M. G., & Richards, A. M. (2004). Looking at the adrenals as a primary source. In Handbook of Hypertension: Vol. 22. Hypertension in the Twentieth Century: Concepts and Achievements. (pp. 104-122). Amsterdam: Elsevier.

Journal - Research Article

Troughton, R. W., Prior, D. L., Pereira, J. J., Martin, M., Fogarty, A. M., Morehead, A., Yandle, T. G., Richards, A. M., … Klein, A. L. (2004). Plasma B-type natriuretic peptide levels in systolic heart failure: Importance of left ventricular diastolic function and right ventricular systolic function. JACC, 43(3), 416-422. doi: 10.1016/j.jacc.2003.08.046

Charles, C. J., Rademaker, M. T., & Richards, A. M. (2004). Urocortins: Putative role in cardiovascular disease. Current Medicinal Chemistry: Cardiovascular & Hematological Agents, 2, 43-47.

Richards, M., & Troughton, R. W. (2004). NT-proBNP in heart failure: Therapy decisions and monitoring. European Journal of Heart Failure, 6(3), 351-354.

The ONTARGET/TRANSCEND Investigators, including Richards, M. (2004). Rationale, design, and baseline characteristics of 2 large, simple, randomized trials evaluating telmisartan, ramipril, and their combination in high-risk patients: The ongoing telmisartan alone and in combination with ramipril global endpoint trial/telmisartan randomized assessment study in ACE intolerant subjects with cardiovascular disease (ONTARGET/TRANSCEND) TRIALS. American Heart Journal, 148(1), 52-61. doi: 10.1016/j.ahj.2004.03.020

Richards, A. M. (2004). The natriuretic peptides in heart failure. Basic Research in Cardiology, 99(2), 94-100.

Richards, A. M., Lainchbury, J. G., Troughton, R. W., Espiner, E. A., & Nicholls, M. G. (2004). Clinical applications of B-type natriuretic peptides. Trends in Endocrinology & Metabolism, 15(4), 170-174.

Gill, D., Troughton, R. W., Yandle, T. G., Frampton, C. M., Richards, M., Lainchbury, J. G., & Nicholls, M. G. (2004). Vigorous response in plasma N-terminal pro-brain natriuretic peptide (NT-BNP) to acute myocardial infarction. Clinical Science, 106(2), 135-139.

Prickett, T. C., Kaaja, R. J., Nicholls, M. G., Espiner, E. A., Richards, A. M., & Yandle, T. G. (2004). N-terminal pro-C-type natriuretic peptide, but not C-type natriuretic peptide, is greatly elevated in the fetal circulation. Clinical Science, 106(5), 535-540.

Wright, S. P., Prickett, T. C., Doughty, R. N., Frampton, C., Gamble, G. D., Yandle, T. G., … Richards, M. (2004). Amino-terminal pro-C-type natriuretic peptide in heart failure. Hypertension, 43(1), 94-100.

Davis, M. E., Pemberton, C. J., Yandle, T. G., Lainchbury, J. G., Rademaker, M. T., Nicholls, M. G., Frampton, C. M., & Richards, A. M. (2004). Urocortin-1 infusion in normal humans. Journal of Clinical Endocrinology & Metabolism, 89(3), 1402-1409.

Yandle, T., Fisher, S., Livesey, J., Espiner, E., Richards, M., & Nicholls, G. (2004). Exponential increase in clinical use of plasma brain natriuretic peptide (BNP) assays. New Zealand Medical Journal, 117(1197). Retrieved from http://journal.nzma.org.nz/journal/117-1197/956/content.pdf

Richards, A. M., & Charles, C. (2004). Urotensin II in the cardiovascular system. Peptides, 25(10), 1795-1802. doi: 10.1016/j.peptides.2004.04.017

Taylor, A. J., Bobik, A., Richards, M., Kaye, D., Raines, G., Gould, P., & Jennings, G. (2004). Myocardial endothelin-1 release and indices of inflammation during angioplasty for acute myocardial infarction and stable coronary artery disease. American Heart Journal, 148(2), 341-347.

Rademaker, M. T., Charles, C. J., Espiner, E. A., Frampton, C. M., Nicholls, M. G., & Richards, A. M. (2004). Combined inhibition of angiotensin II and endothelin suppresses the brain natriuretic peptide response to developing heart failure. Clinical Science, 106, 569-576.

Journal - Research Other

Palmer, B. R., Frampton, C. M., Richards, A. M., Cameron, V. A., & Nakayama, T. (2004). Absence of a NPR-A gene functional deletion allele in a postmyocardial infarction cohort from New Zealand [Letter to the editor]. Circulation Research, 94(10), e86.

Troughton, R. W., Richards, A. M., Yandle, T. G., & Nicholls, M. G. (2004). Routine measurement of natriuretic peptide to guide the diagnosis and management of chronic heart failure [Letter to the editor]. Circulation, 109, e325. doi: 10.1161/01.CIR.0000132585.12965.D6

Journal - Professional & Other Non-Research Articles

Nicholls, M. G., Obineche, E. N., Frampton, C. M., & Richards, A. M. (2004). Plasma cardiac natriuretic peptide levels in screening for cardiac disease [Editorial]. American Journal of Medicine, 116, 561-563.

Conference Contribution - Published proceedings: Abstract

Prickett, T. C. R., Barrell, G. K., Wellby, M., Lynn, A. M., Kaaja, R. J., Cameron, V. A., Espiner, E. A., Richards, A. M., & Yandle, T. G. (2004). Plasma amino-terminal proCNP: A putative marker of growth plate activity. Journal of Bone & Mineral Research, 19(Suppl. 1), (pp. S348). doi: 10.1002/jbmr.5650191306

Ferrier, K., Neill, A., Campbell, A., Richards, M., & O'Meeghan, T. (2004). Nasal continuous positive airway pressure (NCPAP) in obstructive sleep apnoea (OSA) and heart failure (HF). Internal Medicine Journal, 34(Suppl.), (pp. A18). doi: 10.1111/j.1444-0903.2004.abstracts.x

Charles, C., Rademaker, M., Richards, M., & Nicholls, G. (2004). Potential for targeting adrenomedullin mechanisms in heart failure. Journal of Molecular & Cellular Cardiology, 37(S37E), (pp. 345). doi: 10.1016/j.yjmcc.2004.05.003

Pemberton, C. J., Rothwell, S. E., Yandle, T. G., & Richards, A. M. (2004). Ghrelin and resistin: Metabolic hormones influencing cardiac function. First Annual Canterbury Health Research Scientific Conference. (pp. 31). [Abstract]

Pemberton, C. J., Raudsepp, S., Yandle, T. G., & Richards, A. M. (2004). Cardiotrophin-1: Circulating levels, cardiac secretion and molecular forms in cardiovascular disease. New Zealand Medical Sciences Congress AGM. [Abstract]

Cameron, V. A., Palmer, B. R., Pilbrow, A. P., Ellmers, L. J., Scott, N. J. A., Troughton, R. W., Frampton, C. M., Lainchbury, J. G., Yandle, T. G., & Richards, A. M. (2004). Prediction and protection in heart disease. Proceedings of the Medical Sciences Congress 2004. (pp. 27). [Abstract]

Pilbrow, A., Ellmers, L. J., Troughton, R. W., Palmer, B. R., Richards, A. M., Sweet, W., … Cameron, V. A. (2004). Gene expression and genotype in donor and end-stage heart failed myocardium. Proceedings of the Fourteenth Annual Queenstown Molecular Biology Meeting in conjunction with the New Zealand Society for Biochemistry and Molecular Biology. (A59). [Abstract]

Scott, N. J. A., Ellmers, L. J., Lainchbury, J., Maeda, N., Smithies, O., Richards, A. M., & Cameron, V. A. (2004). The role of the natriuretic peptides in gestation in Npr-1-/-mice. Proceedings of the 12th International Congress of Endocrinology. (pp. 275). [Abstract]

Ellmers, L. J., Scott, N. J., Maeda, N., Smithies, O., Richards, A. M., & Cameron, V. A. (2004). Temporal changes in ventricular natriuretic peptide gene expression during developing hypertrophy in Npr-1 knockout mice. Proceedings of the 12th International Congress of Endocrinology. (pp. 276). [Abstract]

Palmer, B. R., Moran, S., McEwen, S., Skelton, L., Frampton, C. M., Pilbrow, A. P., … Troughton, R. W., Yandle, T. G., Richards, A. M., & Cameron, V. A. (2004). The Christchurch cardioendocrine research group DNA bank. Proceedings of the Australian Health and Medical Research Congress. (pp. 328). [Abstract]

Palmer, B. R., Pilbrow, A. P., Collins, R. P., Skelton, L., Frampton, C. M., Troughton, R. W., Yandle, T. G., Richards, A. M., & Cameron, V. A. (2004). Genetic association studies of heart disease in New Zealand. Proceedings of the New Zealand Medical Sciences Congress. (pp. 72). [Abstract]

Palmer, B. R., Collins, R. P., Frampton, C. M., Yandle, T. G., Skelton, L., Richards, A. M., & Cameron, V. A. (2004). AMPD1 T34 mutant allele carriers with a history of previous myocardial infarction have increased mortality in post-myocardial infarction and heart failure cohorts. Proceedings of the 12^th International Congress of Endocrinology. (pp. 120-121). [Abstract]

Rademaker, M., Charles, C., Espiner, E., Lainchbury, J., Nicholls, G., & Richards, M. (2004). Chronic urocortin administration in experimental heart failure. Proceedings of the 12^th International Congress of Endocrinology. (pp. 174-175). [Abstract]

Blake, J. W. H., McClean, D. R., Melton, I. C., Elliott, J. M., Richards, A. M., & Smyth, D. W. (2004). Experience of sirolimus-eluting stents for diffuse bare metal in-stent restenosis. Heart, Lung & Circulation, 13(Suppl. 2), (pp. S78). doi: 10.1016/j.hlc.2004.05.001

Davis, M. E., Pemberton, C. J., Yandle, T. G., Lainchbury, J. G., Rademaker, M. T., Nicholls, M. G., Frampton, C. M., & Richards, A. M. (2004). Urocortin infusion in humans with stable congestive cardiac failure. Heart, Lung & Circulation, 13(Suppl. 2), (pp. S117-S118). doi: 10.1016/j.hlc.2004.05.001

Davis, M. E., Troughton, R. W., Nicholls, M. G., Yandle, T. G., Frampton, C. M., & Richards, M. (2004). Introduction of beta-blocker causes an initial increase in plasma brain natriuretic peptide and N-terminal brain natriuretic peptide levels in patients with stable systolic heart failure. Heart, Lung & Circulation, 13(Suppl. 2), (pp. S117). doi: 10.1016/j.hlc.2004.05.001

Omland, T., Richards, M., Wergeland, R., & Vik-Mo, H. (2004). Circulating B-type natriuretic peptide and N-terminal pro-B-type natriuretic peptide as markers of long-term survival in patients with stable coronary artery disease. Circulation, 110(17), (pp. III-705). [Abstract]

Blake, J. W. H., Elliott, J. M., Ranasinghe, T., Robinson, L., Smyth, D. W., McClean, D. R., & Richards, A. M. (2004). Elevated troponin-T levels after elective percutaneous coronary intervention are often caused by mechanical factors: Lack of effect of pre-treatment with clopidogrel. Heart, Lung & Circulation, 13(Suppl. 2), (pp. S43). doi: 10.1016/j.hlc.2004.05.001

Stewart, R., Gerber, I., Legget, M., West, T., Richards, M., & White, H. (2004). Measurment of aminoterminal B-type natriuretic peptide in asymptomatic aortic stenosis to predict symptomatic deterioration. Heart, Lung & Circulation, 13(Suppl. 2), (pp. S124). doi: 10.1016/j.hlc.2004.05.001

Elliott, J. M., Taylor, A., Su, H., Alspach, A., Falconer, J., Buchan, R. J., … Richards, A. M. (2004). Six year trends in the investigation and treatment of acutemyocardial infarction (AMI). Heart, Lung & Circulation, 13(Suppl. 2), (pp. S65). doi: 10.1016/j.hlc.2004.05.001

Conference Contribution - Poster Presentation (not in published proceedings)

Piuhola, J., Pemberton, C., Hampton, M., & Richards, M. (2004, June). Multiple cardiac effects of erythropoietin. Poster session presented at the 14th European Meeting on Hypertension, Paris.

Conference Contribution - Verbal presentation and other Conference outputs

Rothwell, S. E., Pemberton, C. J., & Richards, A. M. (2004, November). Resistin: A link between metabolic syndrome and cardiovascular disease. Verbal presentation at the Medical Sciences Congress: Physiological Society of New Zealand, Queenstown, New Zealand.

2003

Chapter in Book - Research

Lainchbury, J. G., & Richards, A. M. (2003). Exercise testing in the assessment of chronic congestive heart failure. In P. Mills (Ed.), Education in heart, volume 3. (pp. 56-64). London: BMJ Books.

Richards, M., & Nicholls, G. (2003). Endocrine causes of hypertension. In R. J. Johnson & J. Feehally (Eds.), Comprehensive clinical nephrology. (2nd ed.) (pp. 529-541). London, UK: Mosby.

Journal - Research Article

Executive Steering Committee on behalf of the SPORTIF III Investigators, including Richards, A. M. (2003). Stroke prevention with the oral direct thrombin inhibitor ximelagatran compared with warfarin in patients with non-valvular atrial fibrillation (SPORTIF III): Randomised controlled trial. Lancet, 362(9397), 1691-1698.

Gerber, I. L., Stewart, R. A., French, J. K., Legget, M. E., Greaves, S. C., West, T. M., … Richards, A. M., & White, H. D. (2003). Associations between plasma natriuretic peptide levels, symptoms, and left ventricular function in patients with chronic aortic regurgitation. American Journal of Cardiology, 92(6), 755-758.

Wright, S. P., Doughty, R. N., Pearl, A., Gamble, G. D., Whalley, G. A., Walsh, H., … Yandle, T. G., Richards, A. M., & Sharpe, N. (2003). Plasma amino-terminal pro-brain natriuretic peptide and accuracy of heart-failure diagnosis in primary care: A randomized, controlled trial. JACC, 42(10), 1793-1800. doi: 10.1016/j.jacc.2003.05.011

Rademaker, M. T., Cameron, V. A., Charles, C. J., Lainchbury, J. G., Nicholls, M. G., & Richards, A. M. (2003). Adrenomedullin and heart failure. Regulatory Peptides, 112(1-3), 51-60.

Troughton, R. W., Frampton, C. M., Yandle, T. G., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (2003). Plasma amino-terminal B-type natriuretic peptide measured by Elecsys 2010 assay in a trial of hormone-guided treatment for heart failure. Clinical Chemistry, 49(7), 1212-1215.

Richards, A. M., Nicholls, M. G., Espiner, E. A., Lainchbury, J. G., Troughton, R. W., Elliott, J., Frampton, C., Turner, J., Crozier, I. G., & Yandle, T. G. (2003). B-type natriuretic peptides and ejection fraction for prognosis after myocardial infarction. Circulation, 107(22), 2786-2792. doi: 10.1161/01.CIR.0000070953.76250.B9

Pemberton, C. J., Wimalasena, P., Yandle, T. G., Soule, S. G., & Richards, A. M. (2003). C-terminal pro-ghrelin peptides are present in the human circulation. Biochemical & Biophysical Research Communications, 310(2), 567-573.

Charles, C. J., Elliott, J. M., Nicholls, M. G., Rademaker, M. T., & Richards, A. M. (2003). Natriuretic peptides maintain sodium homoeostasis during chronic volume loading post-myocardial infarction in sheep. Clinical Science, 104(4), 429-436.

Espiner, E. A., Ross, D., Yandle, T. G., Richards, A. M., & Hunt, P. J. (2003). Predicting surgically remedial primary aldosteronism: Role of adrenal scanning, posture testing, and adrenal vein sampling. Journal of Clinical Endocrinology & Metabolism, 88(8), 3637-3644.

Fung, J. W. H., Yu, C. M., Yip, G., Chan, S., Yandle, T. G., Richards, A. M., Nicholls, M. G., & Sanderson, J. E. (2003). Effect of beta blockade (carvedilol or metoprolol) on activation of the renin-angiotensin-aldosterone system and natriuretic peptides in chronic heart failure. American Journal of Cardiology, 92, 406-410.

Nicholls, M. G., Charles, C. J., Lainchbury, J. G., Lewis, L. K., Rademaker, M. T., Richards, A. M., & Yandle, T. G. (2003). Adrenomedullin in heart failure. Hypertension Research, 26(Suppl.), S135-S140. doi: 10.1291/hypres.26.S135

Charles, C. J., Lainchbury, J. G., Nicholls, M. G., Rademaker, M. T., Richards, A. M., & Troughton, R. W. (2003). Adrenomedullin and the renin-angiotensin-aldosterone system. Regulatory Peptides, 112(1-3), 41-49.

Sutton, T. M., Stewart, R. A., Gerber, I. L., West, T. M., Richards, A. M., Yandle, T. G., & Kerr, A. J. (2003). Plasma natriuretic peptide levels increase with symptoms and severity of mitral regurgitation. JACC, 41(12), 2280-2287.

Gerber, I. L., Stewart, R. A., Legget, M. E., West, T., French, R. L., Sutton, T. M., Yandle, T. G., … Richards, A. M., & White, H. D. (2003). Increased plasma natriuretic peptide levels reflect symptom onset in aortic stenosis. Circulation, 107, 1884-1890.

Richards, A. M. (2003). Outpatient management of heart failure. Heart Failure Reviews, 8(4), 345-348.

Palmer, B. R., Pilbrow, A. P., Yandle, T. G., Frampton, C. M., Richards, A. M., Nicholls, M. G., & Cameron, V. A. (2003). Angiotensin-converting enzyme gene polymorphism interacts with left ventricular ejection fraction and brain natriuretic peptide levels to predict mortality after myocardial infarction. JACC, 41(5), 729-736. doi: 10.1016/S0735-1097(02)02927-3

Lainchbury, J. G., Campbell, E., Frampton, C. M., Yandle, T. G., Nicholls, M. G., & Richards, A. M. (2003). Brain natriuretic peptide and N-terminal brain natriuretic peptide in the diagnosis of heart failure in patients with acute shortness of breath. JACC, 42(4), 728-735. doi: 10.1016/S0735-1097(03)00787-3

Journal - Professional & Other Non-Research Articles

Richards, A. M. (2003). Vasopeptidase inhibitors for heart failure: where do we go from here? European Journal of Heart Failure, 5, 411-413.

Conference Contribution - Published proceedings: Abstract

Ranasinghe, T., Robinson, L., Blake, J., Smyth, D. W., Richards, A. M., & Elliott, J. M. (2003). Routine pre-treatment with clopidogrel does not decrease the incidence of troponin T (TnT) elevation after elective percutaneous coronary intervention (PCI). New Zealand Medical Journal, 116(1185). Retrieved from http://journal.nzma.org.nz/journal/116-1185/669/content.pdf

Su, H., Alspach, A., Falconer, J., Buchan, R. J., Jarman, J. P., Robb, B. J., Richards, A. M., & Elliott, J. M. (2003). Lipid-modifying therapy after acute myocardial infarction (AMI): Trends from 1997 to 2002 in Christchurch. New Zealand Medical Journal, 116(1185). Retrieved from http://journal.nzma.org.nz/journal/116-1185/669/content.pdf

Troughton, R. W., Prior, D., Martin, M., Fogarty, A. M., Morehead, A., Starling, R. C., Richards, A. M., … Klein, A. (2003). Echocardiographic determinants of plasma B-type natriuretic peptide levels in symptomatic systolic heart failure. Journal of the American Society of Echocardiography, 16(5), (pp. 500). [Abstract]

Pilbrow, A. P., Palmer, B. R., Yandle, T. G., Frampton, C. M., Richards, A. M., Nicholls, M. G., & Cameron, V. A. (2003). Angiotensin II type I receptor gene polymorphism interacts with N-terminal brain natriuretic peptide levels to predict prognosis in heart failure patients. Proceedings of the Endocrine Society's 85th Annual Meeting. (pp. 451). Chevy Chase, MD, USA: The Endocrine Society Press. [Abstract]

Pilbrow, A. P., Palmer, B. R., Frampton, C. M., Yandle, T. G., Troughton, R. W., Campbell, E., Richards, A. M., Nicholls, M. G., & Cameron, V. A. (2003). AT1R gene polymorphism interacts with N-BNP levels to predict prognosis in heart-failure patients. New Zealand Medical Journal, 116(1174). Retrieved from http://journal.nzma.org.nz/journal/116-1174/443/content.pdf

Troughton, R. W., Prior, D., Prior, J. J., Fogarty, A. M., Martin, M. G., Yandle, T. G., Richards, A. M., … Klein, A. (2003). Relationship of plasma BNP levels to Tissue Doppler and Color M-Mode indices of diastolic function and left ventricular filling pressure in systolic heart failure. JACC, 41(6 (Suppl. A)), (pp. 448A). [Abstract]

Gerber, I. L., Stewart, R. A., Leggett, M., West, T. M., & Richards, A. M. (2003). Higher baseline and increasing serial plasma levels of amino-terminal brain natriuretic peptide predicts sympton onset in aortic stenosis. Circulation, 108(17 Suppl. IV), (pp. 512-513). [Abstract]

Davis, M., Pemberton, C. J., Yandle, T. G., Lainchbury, J. G., Rademaker, M. T., Nicholls, M. G., Frampton, C. M., & Richards, A. M. (2003). First report of urocortin infusion and actions in normal humans. Circulation, 108(17 Suppl. IV), (pp. 242). [Abstract]

Richards, A. M., Lainchbury, J. G., Troughton, R. W., Nicholls, M. G., Frampton, C. M., & Yandle, T. G. (2003). Plasma amino-terminal Pro-B-Type natriuretic peptide predicts postcardioversion reversion to atrial fibrillation. JACC, 41(6 Suppl. 1), (pp. 99A). doi: 10.1016/S0735-1097(03)81042-2

Lainchbury, J. G., Yandle, T. G., Campbell, E., & Richards, A. M. (2003). Brain natriuretic peptide and N-terminal brain natriuretic peptide in the diagnosis of heart failure in patients with acute shortness of breath. JACC, 41(6, Suppl. 1), (pp. 184A). doi: 10.1016/S0735-1097(03)81891-0

Gerber, I. L., Stewart, R. A., Legget, M. E., West, T. M., French, R., French, J. K., Yandle, T. G., Richards, A. M., & White, H. D. (2003). Natriuretic peptide plasma levels remain elevated six months after aortic valve replacement for severe aortic stenosis. JACC, 41(6 Suppl. A), (pp. 508A). [Abstract]

Palmer, B. R., Pilbrow, A. P., Frampton, C. M., Yandle, T. G., Nicholls, M. G., Richards, A. M., & Cameron, V. A. (2003). Angiotensin type I receptor A1166C genotype is associated with left ventricular volume in a New Zealand Post-Myocardial infarction cohort. Circulation, 107(19), (pp. e184). [Abstract]

Conference Contribution - Poster Presentation (not in published proceedings)

Jarvis, M. D., Currie, M., Gunningham, S. P., Palmer, B. R., Richards, A. M., Yandle, T. G., & Cameron, V. A. (2003, June). The effect of cytokines on expression of natriuretic peptide receptors in cultured ovine cardiac fibroblasts. Poster session presented at the The Endocrine Society's 85th Annual Meeting: Shaping the future of endocrinology: Today's research...tomorrow's care, Philadelphia, PA.

Conference Contribution - Verbal presentation and other Conference outputs

Davis, M., Pemberton, C. J., Yandle, T. G., Lainchbury, J. G., Rademaker, M. T., Nicholls, M. G., Frampton, C. M., & Richards, A. M. (2003, November). First report of urocortin infusion and actions in normal humans. Verbal presentation at the American Heart Association Conference 2003, Orlando, USA.

Davis, M., Pemberton, C. J., Yandle, T. G., Lainchbury, J. G., Rademaker, M. T., Nicholls, M. G., Frampton, C. M., & Richards, A. M. (2003, July). First report of urocortin infusion and actions in normal humans. Verbal presentation at the Christchurch Medical Research Conference 2003, Christchurch, NZ.

2002

Chapter in Book - Research

Nicholls, M. G., Richards, A. M., & Yandle, T. G. (2002). The renin-angiotensin system. In G. Mancia, J. Chalmers, S. Julius, T. Saruta, M. Weber, A. Ferrari & I. Wilkinson (Eds.), Manual of Hypertension. (pp. 77-95). London: Churchill Livingstone.

Journal - Research Article

Lainchbury, J. G., & Richards, A. M. (2002). Exercise testing in the assessment of chronic congestive heart failure. Heart, 88, 538-543.

Nicholls, M. G., & Richards, A. M. (2002). Is hypertension a leading cause of heart failure in Chinese? Clinical & Experimental Pharmacology & Physiology, 29(9), 850-851.

Richards, A. M., Nicholls, M. G., Lainchbury, J. G., Fisher, S., & Yandle, T. G. (2002). Plasma urotensin II in human heart failure. Lancet, 360(9332), 545-546.

McGeoch, G. R. B., Lainchbury, J. G., Town, G. I., Toop, L. J., Espiner, E. A., & Richards, A. M. (2002). Plasma brain natriuretic peptide after long-term treatment for heart failure in general practice. European Journal of Heart Failure, 4(4), 479-483.

Pacific Study Group, including Richards, M. (2002). Dose-dependent effects of folic acid on plasma homocysteine in a randomized trial conducted among 723 individuals with coronary heart disease. European Heart Journal, 23, 1509-1515.

Rademaker, M. T., Charles, C. J., Espiner, E. A., Fisher, S., Frampton, C. M., Kirkpatrick, C. M. J., Lainchbury, J. G., Nicholls, M. G., Richards, A. M., & Vale, W. W. (2002). Beneficial hemodynamic, endocrine, and renal effects of urocortin in experimental heart failure: Comparison with normal sheep. JACC, 40(8), 1495-1505.

Rademaker, M. T., Charles, C. J., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (2002). Long-Term adrenomedullin administration in experimental heart failure. Hypertension, 40(5), 667-672.

Rademaker, M. T., Charles, C. J., Cooper, G. J. S., Coy, D. H., Espiner, E. A., Lewis, L. K., Nicholls, M. G., & Richards, A. M. (2002). Combined endopeptidase inhibition and adrenomedullin in sheep with experimental heart failure. Hypertension, 39(1), 93-98.

Richards, A. M., Lainchbury, J. G., Nicholls, M. G., Cameron, V. A., & Yandle, T. G. (2002). Dendroaspis natriuretic peptide: Endogenous or dubious? Lancet, 359(9300), 5-6. England.

Richards, A. M., Nicholls, M. G., Troughton, R. W., Lainchbury, J. G., Elliott, J., Frampton, C., Espiner, E. A., Crozier, I. G., Yandle, T. G., & Turner, J. (2002). Antecedent hypertension and heart failure after myocardial infarction. JACC, 39(7), 1182-1188. doi: 10.1016/S0735-1097(02)01737-0

Rademaker, M. T., Charles, C. J., Cooper, G. J. S., Coy, D. H., Espiner, E. A., Lewis, L. K., Nicholls, M. G., & Richards, A. M. (2002). Combined angiotensin-converting enzyme inhibition and adrenomedullin in an ovine model of heart failure. Clinical Science, 102(6), 653-660.

Cameron, V. A., Autelitano, D. J., Evans, J. J., Ellmers, L. J., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (2002). Adrenomedullin expression in rat uterus is correlated with plasma estradiol. American Journal of Physiology: Endocrinology & Metabolism, 282, E139-E146.

Espiner, E. A., Leikis, R., Ferch, R. D., MacFarlane, M. R., Bonkowski, J. A., Frampton, C. M., & Richards, A. M. (2002). The neuro-cardio-endocrine response to acute subarachnoid haemorrhage. Clinical Endocrinology, 56(5), 629-635.

Charles, C. J., Nicholls, M. G., Rademaker, M. T., & Richards, A. M. (2002). Adrenomedullin modulates the neurohumoral response to acute volume loading in normal conscious sheep. Journal of Endocrinology, 173(1), 123-129.

Journal - Professional & Other Non-Research Articles

Cameron, V. A., & Richards, A. M. (2002). Natriuretic peptide system in fetal heart and circulation. Journal of Hypertension, 20, 801-803.

Yandle, T. G., Nicholls, M. G., & Richards, A. M. (2002). Brain natriuretic peptide: It's function and diagnostic application. Clinical Biochemist Reviews, 23, 3-21.

Richards, A. M., Lainchbury, J. G., Nicholls, M. G., Troughton, R. W., & Yandle, T. G. (2002). BNP in hormone-guided treatment of heart failure. Trends in Endocrinology & Metabolism, 13(5), 151-155. Ovid Technologies INC.

Conference Contribution - Published proceedings: Abstract

Rademaker, M. T., Charles, C. J., Espiner, E. A., Fisher, S., Frampton, C. M., Kirkpatrick, C., Lainchbury, J. G., Nicholls, M. G., & Richards, A. M. (2002). Urocortin has beneficial hemodynamic, endocrine and renal effects in experimental heart failure. Abstracts presented at the Joint Meeting of the 19th Scientific Meeting of the International Society of Hypertension and the 12th European Meeting on Hypertension. 20(supplement), (pp. P1300). Prague, Czech Republic: Lippincott Williams & Wilkins Healthcare. [Abstract]

Wright, S. P., Doughty, R. N., Gamble, G. D., Pomfret, J., Muncaster, S. A., Richards, A. M., Yandle, T. G., & Sharpe, N. (2002). The influence of renal impairment on the clinical utility of BNP as a diagnostic tool in suspected heart failure. Journal of the American College of Cardiology. 39(9), (pp. 396B). Sydney: Elsevier. [Abstract]

Wright, S. P., Doughty, R. N., Gamble, G. D., Pomfret, J., Muncaster, S. A., Richards, A. M., Yandle, T. G., & Sharpe, N. (2002). The influence of diuretic treatment on the diagnostic utility of BNP in suspected heart failure in the community. Journal of the American College of Cardiology. 39(9), (pp. 395B). Sydney: Elsevier. [Abstract]

Sutton, T. M., Kerr, A. J., Gerber, I. L., Stewart, R. A., West, T., Greaves, S. C., … Yandle, T. G., & Richards, A. M. (2002). N-terminal brain natriuretic peptide predicts symptomatic status and severity of mitral regurgitation in patients with mitral regurgitation. Journal of the American College of Cardiology. 39(5), (pp. 431A). Atlanta: Elsevier. [Abstract]

Elliott, J. M., Smyth, D. W., Miller, J., Davis, J., & Richards, A. M. (2002). Improved long term survival after anterior myocardial infarction treated by direct angioplasty/stenting with remote surgical backup. JACC, 39(9), (pp. 2590). Sydney: Elsevier. [Abstract]

Gerber, I. L., Stewart, R. A., French, R., Legget, M. E., Greaves, S. C., Sutton, T. M., Richards, A. M., & White, H. D. (2002). Natriuretic peptides are elevated in aortic regurgitation but correlate poorly with disease severity. Journal of the American College of Cardiology. 39(9), (pp. 350B). Sydney: Elsevier. [Abstract]

Wright, S. P., Gamble, G. D., Pearl, A., Pomfret, J., Walsh, H., Whalley, G. A., Yandle, T., Richards, M., … Doughty, R. N. (2002). The use of brain natriuretic peptide in the diagnosis of heart failure in the community: A randomised controlled effectiveness study. Journal of Cardiac Failure, 8(4, Suppl.), (pp. S13). doi: 10.1016/S1071-9164(02)70012-2

Whitteker, M., Davis, M. E., Begg, E. J., Hammond, G., Livesey, J. L., Nicholls, M. G., Richards, A. M., & Yandle, T. G. (2002). Urocortin-1 adsorption: Implications for dose administration. Proceedings of the Scientific Meeting of the Christchurch Medical Research Society. 115(1161), (pp. 176). Christchurch: New Zealand Medical Journal. [Abstract]

Ellmers, L. J., Palmer, B. R., Jarvis, M., Richards, A. M., & Cameron, V. A. (2002). Cardiac gene expression of urocortins and adrenomedullin in Npr1^-/- deficient mice. Proceedings of Australian Society for Biochemistry and Molecular Biology and Australia and New Zealand Society for Cell & Developmental Biology Combined conference. 34, (pp. POS-MON-095). Kent Town: Australian Society for Biochemistry and Molecular Biology, Inc. [Abstract]

Palmer, B. R., Pilbrow, A. P., Frampton, C. M., Yandle, T. G., Nicholls, M. G., Richards, A. M., & Cameron, V. A. (2002). ACE insertion/deletion genotype is associated with prognosis in a New Zealand post-myocardial infarction cohort. Circulation, 105(14), (pp. e101-e102). [Abstract]

Jarvis, M. D., Currie, M., Gunningham, S. P., Hanrahan, V., Palmer, B. R., Ellmers, L. J., Richards, A. M., & Cameron, V. A. (2002). Expression of natriuretic peptides in cultured ovine cardiac fibroblasts. Proceedings of the 12th Annual Queenstown Molecular Biology Meeting. (pp. T6). Queenstown: Queenstown Molecular Biology Meeting, Inc. [Abstract]

Conference Contribution - Verbal presentation and other Conference outputs

Rademaker, M. T., Charles, C. J., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (2002, November). Chronic adrenomedullin administration in experimental heart failure. Verbal presentation at the 3rd International Symposium on Adrenomedullin and PAMP, Osaka, Japan.

Rademaker, M. T., Charles, C. J., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (2002). hronic adrenomedullin administration in experimental heart failure. Verbal presentation at the 3rd International Symposium on Adrenomedullin and PAMP, Osaka, Japan.

2001

Journal - Research Article

Nicholls, M. G., Lainchbury, J. G., Lewis, L. K., McGregor, D. O., Richards, A. M., Troughton, R. W., & Yandle, T. G. (2001). Bioactivity of adrenomedullin and proadrenomedullin N-terminal 20 peptide in a man. Peptides, 22, 1745-1752.

Nicholls, M. G., Lainchbury, J. G., Lewis, L. K., McGregor, D. O., Richards, A. M., Troughton, R. W., & Yandle, T. G. (2001). Bioactivity of adrenomedullin and proadrenomedullin N-terminal 20 peptide in man. Peptides, 22(11), 1745-1752.

Aitken, G. D., Cameron, V. A., Rademaker, M. T., Charles, C. J., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (2001). Increased atrial but not ventricular ANP and BNP expression in a paced model of heart failure. Journal of Biochemistry, Molecular Biology & Biophysics, 5, 199-207.

Nicholls, M. G., Lainchbury, J. G., Richards, A. M., Troughton, R. W., & Yandle, T. G. (2001). Brain natriuretic peptide-guided therapy for heart failure. Annals of Medicine, 33(6), 422-427.

McGregor, D. O., Troughton, R. W., Frampton, C. M., Lynn, K. L., Yandle, T. G., Richards, A. M., & Nicholls, M. G. (2001). Hypotensive and natriuretic actions of adrenomedullin in subjects with chronic renal impairment. Hypertension, 37(5), 1279-1284.

Richards, A. M., Doughty, R. N., Nicholls, M. G., MacMahon, S., Sharpe, N., Murphy, J., Espiner, E. A., Frampton, C. M., & Yandle, T. G. (2001). Plasma N-terminal pro-brain natriuretic peptide and adrenomedullin: Prognostic utility and prediction of benefit from carvedilol in chronic ischemic left ventricular dysfunction. JACC, 37(7), 1781-1787.

Troughton, R. W., Frampton, C. M., Lewis, L. K., Yandle, T. G., Richards, A. M., & Nicholls, M. G. (2001). Differing thresholds for modulatory effects of adrenomedullin infusion on hemodynamic and hormone responses to angiotensin II and adrenocorticotrophic hormone in healthy volunteers. Clinical Science, 101, 103-109.

Richards, A. M., Lainchbury, J. G., & Nicholls, M. G. (2001). Unsatisfactory redefinition of myocardial infarction. Lancet, 357, 1635-1636.

Prickett, T., Yandle, T. G., Nicholls, M. G., Espiner, E. A., & Richards, A. M. (2001). Identification of amino-terminal pro-C-type natriuretic peptide in human plasma. Biochemical & Biophysical Research Communications, 286(3), 513-517.

Doughty, R. N., & Richards, A. M. (2001). Clinical use of beta-blocker therapy in patients with heart failure: A practical guide. New Zealand Medical Journal, 114, 36-38.

Charles, C. J., Rademaker, M. T., Richards, A. M., & Nicholls, M. G. (2001). Adrenomedullin augments the neurohumoral response to haemorrhage in non-pregnant but not in pregnant sheep. Journal of Endocrinology, 171(2), 363-371.

Charles, C. J., Nicholls, M. G., Rademaker, M. T., & Richards, A. M. (2001). Comparative actions of adrenomedullin and nitroprusside: Interactions with ANG II and norepinephrine. American Journal of Physiology: Regulatory, Integrative & Comparative Physiology, 281(6), R1887-R1894.

Cameron, V. A., Cumming, S. A., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (2001). C-type natriuretic peptide expression in olfactory regions of rat brain is modulated by acute water deprivation, salt loading and central angiotensin II. Neuroendocrinology, 73, 46-53.

Journal - Professional & Other Non-Research Articles

Troughton, R. W., Richards, A. M., & Nicholls, M. G. (2001). Individualized treatment of heart failure. Internal Medicine Journal, 31, 138-141.

Conference Contribution - Published proceedings: Full paper

Richards, A. M., Nicholls, M. G., Espiner, E. A., Troughton, R. W., Lainchbury, J. G., Elliott, J. M., Crozier, I. G., Frampton, C. M., Turner, J. G., & Yandle, T. G. (2001). Superiority of plasma aminoterminal BNP over left ventricular ejection fraction for prognosis after myocardial infarction. European Heart Journal. 22(210A). [Full Paper]

Conference Contribution - Published proceedings: Abstract

Espiner, E. A., Cameron, A. V., Charles, C., Nicholls, M. G., Rademaker, M. T., Richards, A. M., & Yandle, T. (2001). The endocrine heart. Proceedings of the New Zealand Endocrine Society Annual Meeting. (pp. A43). [Abstract]

Pilbrow, A. P., Palmer, B. R., Frampton, C. M., Richards, A. M., & Cameron, A. V. (2001). ACE gene polymorphism is associated with prognosis following myocardial infarction. Proceedings of the Eleventh Annual Queenstown Molecular Biology Meeting. [Abstract]

Barmby, D. S., Sands, J., Bridgman, P. G., Elliott, J. M., Richards, A. M., & Smyth, D. W. (2001). In-stent thrombosis: Analysis of the first 1000 coronary angioplasties at Christchurch Hospital. Proceedings of the New Zealand Regional Scientific Meeting, Cardiac Society of Australia and New Zealand, In New Zealand Medical Journal. 114, (pp. 241). Rotorua. [Abstract]

Richards, A. M., Nicholls, M. G., Troughton, R. W., Lainchbury, J. G., Frampton, C. M., Espiner, E. A., Ikram, H., Yandle, T. G., & Turner, J. G. (2001). Antecedent hypertension and risk of heart failure after myocardial infarction. Journal of the American College of Cardiology. 37(2 Supplement A), (pp. 869-5). [Abstract]

Neal, B., MacMahon, S., Tondin, A., Dudman, N., Hunt, D., Richards, A. M., … Cleverley, Y. (2001). Dose-dependent effects of folic acid on plasma homocysteine levels among 723 individuals with coronary heart disease: The PACIFIC Study. Journal of the American College of Cardiology. 37(2 Supplement A), (pp. 1A-648A). [Abstract]

MacMahon, S., Tonkin, A., Neal, B., Hunt, D., Richards, A. M., Simes, J., … Murphy, J. (2001). Effects of omapatrilat on blood pressure and neurohormone levels among 723 individual with coronary heart disease - The PACIFIC Study. Circulation, 104(17), (pp. II-601). [Abstract]

Gerber, I. L., Stewart, R. A., French, R., Legget, M. E., Greaves, S. C., Richards, A. M., Yandle, T. G., … White, H. D. (2001). Natriuretic peptides in severe aortic valve disease: Potential for monitoring disease progression. Circulation, 104(17), (pp. II-360). [Abstract]

Ovens, L., Bridgman, P. G., Richards, A. M., Smyth, D. W., & Elliott, J. M. (2001). A new elective angioplasty programme: Trends in the first 500 cases at Christchurch Hospital. New Zealand Medical Journal. 114, (pp. 243). [Abstract]

Conference Contribution - Verbal presentation and other Conference outputs

Charles, C. J., Nicholls, M. G., Rademaker, M. T., & Richards, A. M. (2001). Andrenomedullin augments the neurohumoral response to hemorrhage in non-pregnant but not pregnant sheep. Verbal presentation at the 34th International Congress of Physiological Sciences, Christchurch.

Rademaker, M. T., Charles, C. J., Lewis, L. K., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (2001). Combined adrenomedullin adminstration and angiotensin-converting enzyme inhibition in experimental heart failure. Verbal presentation at the 34th International Congress of Physiological Sciences, Christchurch.

Charles, C. J., Nicholls, M. G., Rademaker, M. T., & Richards, A. M. (2001, August). Adrenomedullin augments the neurohumoral response to hemorrhage in non-pregnant but not pregnant sheep. Verbal presentation at the 34th International Congress of Physiological Sciences, Christchurch, New Zealand.

Rademaker, M. T., Charles, C. J., Espiner, E. A., Lewis, L. K., Nicholls, M. G., & Richards, A. M. (2001, August). Combined adrenomedullin administration and angiotensin-converting enzyme inhibition in experimental heart failure. Verbal presentation at the 34th International Congress of Physiological Sciences, Christchurch, New Zealand.

2000

Chapter in Book - Research

Richards, A. M., Lainchbury, J. G., Nicholls, M. G., & Rademaker, M. T. (2000). Adrenomedullin in heart failure: Biochemical curiosity or pathophysiological player? In J. J. V. McMurray & J. G. F. Cleland (Eds.), Heart Failure in Clinical Practice. (2nd ed.) (pp. 105-125). London: Martin Dunitz.

Chapter in Book - Other

Richards, A. M., Nicholls, M. G., & Troughton, R. W. (2000). Diuretic therapy: Essential in heart failure. In N. Sharpe (Ed.), Heart failure management. (pp. 43-59). United Kingdom: Martin Dunitz.

Nicholls, M. G., Richards, A. M., & Begg, E. J. (2000). Hypertension as a cause of heart failure: Is it still important? In J. J. V. McMurray & J. G. F. Cleland (Eds.), Heart failure in clinical practice. (2nd ed.) (pp. 19-31). United Kingdom: Martin Dunitz.

Journal - Research Article

Troughton, R. W., Frampton, C. M., Yandle, T. G., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (2000). Treatment of heart failure guided by plasma aminoterminal brain natriuretic peptide (N-BNP) concentrations. Lancet, 355(9210), 1126-1130. doi: 10.1016/S0140-6736(00)02060-2

Charles, C. J., Rademaker, M. T., Richards, A. M., Cooper, G. J. S., Coy, D. H., & Nicholls, M. G. (2000). Adrenomedullin attenuates pressor response to angiotensin II in concious sheep. Journal of Cardiovascular Pharmacology, 36, 526-532.

Smith, M. W., Espiner, E. A., Yandle, T. G., Charles, C. J., & Richards, A. M. (2000). Delayed metabolism of human brain natriuretic peptide reflects resistance to neutral endopeptidase. Journal of Endocrinology, 167(2), 239-246.

Cameron, V. A., Rademaker, M. T., Ellmers, L. J., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (2000). Atrial (ANP) and brain natriuretic peptide (BNP) expression after myocardial infarction in sheep: ANP is synthesized by fibroblasts infiltrating the infarct. Endocrinology, 141(12), 4690-4697. doi: 10.1210/endo.141.12.7847

Troughton, R. W., Rademaker, M. T., Powell, J. D., Yandle, T. G., Espiner, E. A., Frampton, C. M., Nicholls, M. G., & Richards, A. M. (2000). Beneficial renal and hemodynamic effects of omapatrilat in mild and severe heart failure. Hypertension, 36(4), 523-530.

Troughton, R. W., Lewis, L. K., Yandle, T. G., Richards, A. M., & Nicholls, M. G. (2000). Hemodynamic, hormone, and urinary effects of adrenomedullin infusion in essential hypertension. Hypertension, 36, 588-593.

Swinburn, B., Milne, R. J., Richards, A. M., Begg, E. J., Foote, S., & Jackson, R. (2000). Reimbursement of pharmaceuticals in New Zealand: Comments on PHARMAC's processes. New Zealand Medical Journal, 113, 425-427.

Richards, A. M. (2000). Funding of biomedical research in New Zealand. New Zealand Medical Journal, 113, 400-403.

Rademaker, M. T., Cameron, V. A., Charles, C. J., Espiner, E. A., Nicholls, M. G., Pemberton, C. J., & Richards, A. M. (2000). Neurohormones in an ovine model of compensated post-infarction left ventricular dysfunction. American Journal of Physiology: Heart & Circulatory Physiology, 278, H731-H740.

McClean, D. R., Ikram, H., Garlick, A. H., Richards, A. M., Nicholls, M. G., & Crozier, I. G. (2000). The clinical, cardiac, renal, arterial and neurohormonal effects of Omapatrilat, a vasopeptidase inhibitor, in patients with chronic heart failure. JACC, 36, 479-486.

Lainchbury, J. G., Troughton, R. W., Lewis, L. K., Yandle, T. G., Richards, A. M., & Nicholls, M. G. (2000). Haemodynamic, hormonal and renal effects of short-term adrenomedullin infusion in healthy volunteers. Journal of Clinical Endocrinology & Metabolism, 85, 1016-1020.

Charles, C. J., Elliott, J. M., Nicholls, M. G., Rademaker, M. T., & Richards, A. M. (2000). Myocardial infarction with and without reperfusion in sheep: Early cardiac and neurohumoral changes. Clinical Science, 98, 703-711.

Journal - Research Other

Richards, A. M. (2000). The safety of calcium antagonists: An update. Prescriber Update, 19, 4-13. Retrieved from https://www.moh.govt.nz

Journal - Professional & Other Non-Research Articles

Troughton, R. W., Lainchbury, J. G., McGregor, D. O., Richards, A. M., & Nicholls, M. G. (2000). Adrenomedullin in hypertension. Current Hypertension Reports, 1, 1-2.

Conference Contribution - Published proceedings: Abstract

Charles, C. J., Rademaker, M. T., Richards, A. M., Cooper, G. J. S., Coy, D. H., & Nicholls, M. G. (2000). Adrenomedullin attenuates pressor response to angiotensin II in concious sheep. 11th International Congress of Endocrinology. 36. [Abstract]

Troughton, R. W., Yandle, T. G., Richards, A. M., & Nicholls, M. G. (2000). Adrenomedullin infusion in subjects with essential hypertension. Heart, Lung & Circulation, 9(3), (pp. A154). [Abstract]

McGregor, D. O., Troughton, R. W., Lynn, K., Yandle, T. G., Richards, A. M., & Nicholls, M. G. (2000). Adrenomedullin infusion in chronic renal impairment. Proceedings of the 18th Scientific Meeting of the International Society of Hypertension. (pp. P372). Chicago. [Abstract]

McLean, D., Ikram, H., Crozier, I. G., Garlick, A., Richards, A. M., & Nicholls, M. G. (2000). Long-term vasopeptidase inhibition with omapatrilat produces improvements in wave reflection and maximum vasodilator capacity in chronic heart failure. Proceedings of the XXII Congress of the European Society of Cardiology. (pp. P1657). Amsterdam. [Abstract]

Richards, A. M. (2000). Clinical utility of biochemical markers in CHF. Proceedings of the 48th Annual Scientific Meeting of the Cardiac Society of Australia and New Zealand. (pp. 61). Melbourne. [Abstract]

Richards, A. M., Nicholls, M. G., Yandle, T. G., Turner, J. G., & Troughton, R. W. (2000). Hypertension and cardiovascular events after myocardial infarction. Proceedings of the 48th Annual Scientific Meeting of the Cardiac Society of Australia and New Zealand. (pp. 177). Melbourne. [Abstract]

Ellmers, L. J., Knowles, J., Smithies, O., Nicholls, M. G., Espiner, E. A., Richards, A. M., & Cameron, V. A. (2000). Atrial natriuretic peptide and brain natriuretic peptide gene expression in natriuretic peptide receptor-A deficient mice. Proceedings of the 4th Annual Meeting of the Society for Cardiovascular Endocrinology and Metabolism. (pp. A7). Palm Cove, Queensland. [Abstract]

Charles, C. J., Rademaker, M. T., Richards, A. M., & Nicholls, M. G. (2000). Interactions of adrenomedullin with incremental infusions of angiotensin II and norepinephrine in conscious sheep; comparison with nitroprusside. Proceedings of 11th International Congress of Endocrinology. (pp. 985). Sydney. [Abstract]

Conference Contribution - Verbal presentation and other Conference outputs

Rademaker, M. T., Charles, C. J., Cooper, G. J. S., Coy, D. H., Espiner, E. A., Lewis, L. K., Nicholls, M. G., Pemberton, C. J., & Richards, A. M. (2000, October). Combined adrenomedullin administration and neutral endopeptidase inhibitor in heart failure. Verbal presentation at the 4th Annual Meeting of the Society for Cardiovascular Endocrinology and Metabolism, Australia.

Cameron, A. V., Autelitano, D. J., Evans, J. J., Ellmers, L. J., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (2000, October). Adrenomedullin expression in rat uterus is correlated positively with plasma oestradiol and inversely with plasma progesterone. Verbal presentation at the Eleventh International Congress of Endocrinology, Sydney, Australia.

Charles, C. J., Nicholls, M. G., Rademaker, M. T., & Richards, A. M. (2000). Adrenomedullin augments the neurohumoral response to hemorrhage in normal conscious sheep. Verbal presentation at the 4th Annual Meeting of the Society for Cardiovascular Endocrinology and Metabolism, Queensland.

Rademaker, M. T., Charles, C. J., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (2000, October/November). Combined adrenomedullin administration and neutral endopeptidase inhibition in heart failure. Verbal presentation at the 11 th International Congress of Endocrinology, Sydney.

Troughton, R. W., McGregor, D. O., Charles, C. J., Lewis, L. K., Yandle, T., Richards, A. M., & Nicholls, M. G. (2000). Biological effects of adrenomedullin infusion in healthy volunteers, essential hypertension and chronic renal failure. Verbal presentation at the 2nd International Symposium on Adrenomedullin and PAMP, Japan.

1999

Chapter in Book - Research

Richards, A. M. (1999). Combined angiotensin convertin enzyme inhibition and angiotensin II type 1 receptor antagonism. In M. G. Nicholls, H. R. Brunner, H. Ikram, C. S. Sweet & J. F. Walker (Eds.), 100 Years of the Renin-Angiotensin System. (pp. 90-95). New Jersey, USA: Merck & Co..

Richards, A. M., Nicholls, M. G., & Troughton, R. W. (1999). The pharmacotherapy of diuretics. In N. Sharpe (Ed.), Heart Failure Management 2000. (pp. 43-60). London: Martin Dunitz.

Nicholls, M. G., Richards, A. M., & Begg, E. J. (1999). Hypertension as a cause of heart failure: Is it still important? In J. J. V. McMurray & J. G. F. Cleland (Eds.), Heart Failure in Clinical Practice. (pp. 19-32). London: Martin Dunitz.

Journal - Research Article

Seidler, T., Pemberton, C. J., Yandle, T. G., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (1999). The amino terminal regions of proBNP and proANP: Oligomerise through leucine zipper-like coiled-coil motifs. Biochemical & Biophysical Research Communications, 255, 495-501.

Richards, A. M., & Nicholls, M. G. (1999). Aldosterone antagonism in heart failure. Lancet, 354(9181), 789-790.

Richards, A. M., Doughty, R. N., Nicholls, M. G., MacMahon, S., Ikram, H., Sharpe, N., Espiner, E. A., Frampton, C. M., & Yandle, T. G. (1999). Neurohumoral prediction of benefit from carvedilol in ischemic left ventricular dysfunction. Circulation, 99(6), 786-792.

Richards, A. M., Nicholls, M. G., Yandle, T. G., Ikram, H., Espiner, E. A., Turner, J. G., … Lainchbury, J. G., Elliott, J. M., Frampton, C. M., Crozier, I. G., & Smyth, D. W. (1999). Neuroendocrine prediction of left ventricular function and heart failure after acute myocardial infarction. Heart, 81, 114-120.

Nicholls, M. G., & Richards, A. M. (1999). The salt dilemma: some answers, many questions (invited editorial). Medical Journal of Australia, 170(4), 178-180.

Lainchbury, J. G., Richards, A. M., Nicholls, M. G., Espiner, E. A., & Yandle, T. G. (1999). Brain natriuretic peptide and neutral endopeptidase inhibition in left ventricular impairment. Journal of Clinical Endocrinology & Metabolism, 84(2), 723-729. doi: 10.1210/jcem.84.2.5489

Lainchbury, J. G., Nicholls, M. G., Espiner, E. A., Yandle, T. G., Lewis, L. K., & Richards, A. M. (1999). Bioactivity and interactions of adrenomedullin and brain natriuretic peptide in patients with heart failure. Hypertension, 34(1), 70-75.

Fay, M. F., Nicholls, M. G., & Richards, A. M. (1999). A man with severe, transient hypertension due to acute renal infarction. J Human Hypertens, 13(5), 343-344.

Agarwal, M., Lynn, K., Richards, A. M., & Nicholls, M. G. (1999). Hyponatremic-hypertensive syndrome with renal ischemia: an underrecognized disorder. Hypertension, 33(4), 1020-1024.

Charles, C. J., Lainchbury, J. G., Lewis, L. K., Rademaker, M. T., Richards, A. M., Yandle, T. G., & Nicholls, M. G. (1999). The role of adrenomedullin. American Journal of Hypertension, 12(2 Part 1), 166-173.

Charles, C. J., Espiner, E. A., Nicholls, M. G., Rademaker, M. T., & Richards, A. M. (1999). Bioactivity of natriuretic peptide coinfusions: no evidence for unique effects of BNP in conscious sheep. Journal of Cardiovascular Pharmacology, 33(2), 229-236.

Journal - Professional & Other Non-Research Articles

Yandle, T. G., Fisher, S., Espiner, E. A., Richards, A. M., & Nicholls, M. G. (1999). Validating aminoterminal BNP assays: a word of caution. Lancet, 353(9158), 1068-1069.

Conference Contribution - Published proceedings: Abstract

Cameron, A. V., Rademaker, M. T., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (1999). Regional and temporal comparison of atrial and brain natriuretic peptide gene expression in an ovine model of myocardial infarction. 1st International Congress on Heart Disease - New Trends in Research, Diagnosis and Treatment. 1(1). The Journal of Heart Disease. [Abstract]

Elliott, J. M., Jackson, N. W., Frampton, C. M., Smyth, D. W., & Richards, A. M. (1999). Quality of life while waiting for, and during recovery from, coronary bypass surgery (CABG) or angioplasty (PTCA). The Cardiac Society of Australia and New Zealand. Wellington. [Abstract]

Lainchbury, J. G., Troughton, R. W., Lewis, L. K., Yandle, T. G., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (1999). Low and high dose adrenomedullin infusion in normal volunteers. 72nd Scientific Sessions, American Heart Foundation. 100(18), (pp. I-350). Circulation. [Abstract]

Richards, A. M., Webb, D. J., Yandle, T. G., Johnston, N. R., Nicholls, M. G., Elliott, J. M., … Lainchbury, J. G., Troughton, R. W., & Turner, J. G. (1999). Comparison of amino-terminal pro-brain natriuretic peptide and "big" endothelin 1 as prognostic indicators after myocardial infarction (poster presentation). Journal of the American College of Cardiology. 32. [Abstract]

Richards, A. M. (1999). Epidemiology, detection, newer medical approaches to heart failure (invited lecture). Cardiac Rehabilitation Association of New Zealand, Inaugural National Conference. [Abstract]

Richards, A. M. (1999). New hormones in heart failure. Cardiac Society of Australia and New Zealand 47th Annual Scientific Meeting. [Abstract]

Smyth, D. W., Richards, A. M., Hart, C., & Elliott, J. M. (1999). Abciximab decreases "slow flow" during direct angioplasty for acute anterior myocardial infarction: a randomised study. American College of Cargiology 48th Scientific Session. [Abstract]

Conference Contribution - Verbal presentation and other Conference outputs

Rademaker, M. T., Troughton, R. W., Charles, C. J., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (1999, August). Acute and chronic administration of Omapatrilat in an ovine model of mild and severe heart failure. Verbal presentation at the 2nd BCCH Symposium, Sydney, Australia.

Charles, C. J., Elliott, J. M., Nicholls, M. G., Rademaker, M. T., & Richards, A. M. (1999). Myocardial infarction with and without reperfusion in sheep: Cardiac, neurohumoral and hemodynamic effects. Verbal presentation at the 1st International Congress on Heart Disease, Washington DC, USA.

Cameron, A. V., Rademaker, M. T., Ellmers, L. J., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (1999). Comparison of atrial and brain natriuretic peptide expression in ovine heart after myocardial infarction. Verbal presentation at the 2nd BCCH Symposium, Sydney, Australia.

Rademaker, M. T., Troughton, R. W., Charles, C. J., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (1999). Acute and chronic administration of omapatrilat in an ovine model of mild and severe heart failure. Verbal presentation at the 47th Annual Meeting Cardiac Society of Australia and New Zealand, Wellington, New Zealand.

Charles, C. J., Elliott, J. M., Nicholls, M. G., Rademaker, M. T., & Richards, A. M. (1999). Myocardial infarction with and without reperfusion in sheep: Cardiac, neurohumoral and hemodynamic effects. Verbal presentation at the 1st International Congress in Heart Disease, Washington DC, USA.

1998

Journal - Research Other

Nicholls, M. G., Richards, A. M., Moller, P. W., Elliott, J. M., & Begg, E. J. (1998). Health authorities in New Zealand have spin doctors to produce good news [Letter]. British Medical Journal, 316, 1321.

Conference Contribution - Published proceedings: Full paper

Richards, A. M. (1998). Can we stop the kidneys letting us down in heart failure? New Zealand Regional Scientific Meeting, The Cardiac Society of Australia and New Zealand. Christchurch. [Full Paper]

Richards, A. M. (1998). Heart Failure: new methods of flogging the dead horse. New Zealand Regional Scientific Meeting, The Cardiac Society of Australia and New Zealand. Christchurch. [Full Paper]

Richards, A. M. (1998). Gene technologies and cardiovascular disease. "Foresight" Meeting: Using Gene Technologies. [Full Paper]

Richards, A. M. (1998). The therapeutic potential of combined ACE and NEP inhibition. Second Annual Meeting of the Heart Failure Society of America. Florida. [Full Paper]

Richards, A. M. (1998). BNP compared to endothelin as indicators of cardiac function and prognosis after myocardial infarction. First International Symposium of Cardiovascular Endocrinology and Metabolism. Kyoto. [Full Paper]

Richards, A. M. (1998). Heart Failure in the community and the problem of diagnosis. High Blood Pressure Council of Australia, 20th Annual Scientific Meeting. Melbourne. [Full Paper]

Conference Contribution - Published proceedings: Abstract

Elliott, J. M., Smyth, D. W., Lainchbury, J. G., Tisch, J., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (1998). Correlations between atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and left ventricular ejection fraction (LVEF) after direct angioplasty (PTCA) or thrombolysis (TS) in acute anterior myocardial infarction (AMI). Australian and New Zealand Journal of Medicine. 28, (pp. 139). [Abstract]

Lainchbury, J. G., Richards, A. M., Nicholls, M. G., Espiner, E. A., & Yandle, T. G. (1998). Effects of BNP infusion and NEP inhibition in heart failure. Australian and New Zealand Journal of Medicine. 28, (pp. 119). [Abstract]

Charles, C. J., Espiner, E. A., Rademaker, M. T., Nicholls, M. G., & Richards, A. M. (1998). Chronic infusions of brain natriuretic peptide in conscious sheep: Bioactivity at low physiological levels. Journal of Hypertension. 16(Suppl. 2), (pp. S143). [Abstract]

Rademaker, M. T., Charles, C. J., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (1998). Natriuretic peptides and endothelin on an ovine coronary artery ligation model of mild heart failure. 80th Annual Endocrine Society Meeting Programme. (A326). [Abstract]

Jackson, N. W., Doogue, M. P., Crozier, I. G., Ikram, H., Richards, A. M., Smyth, D. W., & Elliott, J. M. (1998). Waiting for coronary artery bypass surgery (CABG) in Christchurch. Proceedings of the New Zealand Regional Meeting of the Cardiac Society of Australia and New Zealand. 111(1067 (sup)), (pp. 41). New Zealand Medical Journal. [Abstract]

Conference Contribution - Verbal presentation and other Conference outputs

Rademaker, M. T., Charles, C. J., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (1998). Netriuretic peptides and endothelin un an ovine coronary ligation model of mild heart failure. Verbal presentation at the Endo '98, New Orleans.

Lainchbury, J. G., Rademaker, M. T., Charles, C. J., Lewis, L. K., Yandle, T. G., Richards, A. M., & Nicholls, M. G. (1998). Adrenomedullin in heart failure. Verbal presentation at the Centre of Excellence International Symposium on Adrenomedullin and PAMP, Osaka, Japan.

Rademaker, M. T., Troughton, R. W., Charles, C. J., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (1998, November). Acute and chronic administration of Omapatrilat in an ovine model of mild and severe heart failure. Verbal presentation at the American Heart Association Meeting, Atlanta, USA.