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Clinical Research in the Christchurch Heart Institute

Nicholls research centre research participants

Research focus

The main focus for clinical projects have the common theme of investigating neurohumoral aspects of common cardiovascular diseases including:

  • Myocardial infarction
  • Hypertension
  • Atrial fibrillation and
  • Heart failure

Participation in multi-centre trials of experimental treatments for these conditions is also part of our programme.

Some recent high profile publications from this team:

Adamson, P.D., McAllister, D.A., Pilbrow, A., Pickering, J.W., Poppe, K. K., Shah, A. S. V., Whalley, G.A., Ellis, C.J., Mills, N.L., Newby, D.E., Pemberton, C.J., Troughton, R., Doughty, R.N., Richards, A.M. (2019). Convalescent Troponin and Cardiovascular Death following Acute Coronary Syndrome. Heart Jul 23 pii: heartjnl-2019-315084. doi: 10.1136/heartjnl-2019-315084.

Scott, N.J.A., Rademaker, M.T., Charles, C.J., Espiner, E.A., Richards, A.M. (2019). Phosphodiesterase-9Inhibition: Integrated Hemodynamic, Hormonal and Renal Actions in Health and Experimental Heart Failure. J Am Coll Cardiol 74:889-901 doi: 10.1016/j.jacc.2019.05.067.

Lewis, L.K., Raudsepp, S.D., Prickett, T.C.R., Yandle, T.G., Doughty, R.N., Frampton, C.M., Pemberton, C.J., Richards, A.M. (2019). ProBNP that is Not Glycosylated at Threonine 71 is Decreased With Obesity in Patients with Heart Failure. Clin Chem 2019.302547. doi: 0.1373/clinchem.2019. 302547.

Wong, L.L., Zou, R., Zhou, L., Lim, J.Y., Yang, D.P.C., Liu, C., Chong, J.P.C., Ng, J.Y.X., Liew, O.W., Chan, S.P., Chen, Y.T., Chan, M.M.Y., Yeo, P.S.D., Ng, T.P., Ling, L.H., Sim, D., Leong, K.T.G., Ong, H.Y., Jaufeerally, F., Wong, R., Chai, P., Low, A.F., Lund, M., Devlin, G., Troughton, R., Cameron, V.A., Doughty, R.N., Lam, C.S.P., Too, H.P., Richards, A.M. (2019). Combining Circulating MicroRNA and NT-proBNP for Detecting Non-acute Heart Failure and Categorizing Heart Failure Subtype. J Am Coll Cardiol. 2019;7311:1300-1313.

Pickering, J.W., Young, J.M., Watson, A.S., George, P.M., Aldous, S.J., Troughton, R.W., Pemberton, C.J., Richards, A.M., Cullen, L.A., Than, M.P. (2018). Validity of a Novel Point-of-Care Troponin Assay for Single-Test Rule-Out of Acute Myocardial Infarction. JAMA Cardiol. Nov 1;3(11):1108-1112.

Than, M.P., Aldous, S.J., Troughton, R., Pemberton, C.J., Richards, A.M., Frampton, C.M.A., Florkowski, C.M., George, P.M., Bailey, S., Young, J.M., Cullen, L., Greenslade, J.H., Parsonage, W.A., Everett, B.M., Peacock, W.F., Jaffe, A.S., Pickering, J.W. (2018). Detectable high-sensitivity troponin within the population reference range conveys high 5-year cardiovascular risk: An observational study. Clin Chem 64:1044-1053. doi: 10.1373/clinchem.2017.285700.

Lam, C.S.P., Gamble, G.D., Ling, L.H., Sim, D., Leong, K.T.G., Yeo, P.S.D., Ong, H.Y., Jaufeerally, F., Ng, T.P., Cameron, V.A., Poppe, K., Lund, M., Devlin, G., Troughton, R., Richards, A.M., Doughty, R.N. (2018). Mortality Associated With Heart Failure With Preserved Versus Reduced Ejection Fraction In A Prospective International Multi-Ethnic Cohort Study. Eur Heart J 39: 1770-1780 doi:10.1093/ eurheartj /ehy005.

Senior academic and research staff

Scientist

Biostatistician

Clinical Research Manager

  • Lorraine Skelton

Research staff

  • Alieke Dierckx
  • Dr Charlotte Greer
  • Judy Heslop
  • Cindy Kim
  • Barbara Neame
  • Rakesh Mathal
  • Liz Ridder

Research nurses

  • Ashleigh Brenssell
  • Ruth Jardine
  • Stephanie Rose
  • Rachel Saunders

Cardiac Sonographer

  • Laura Perston