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Translational biodiscovery research in the Christchurch Heart Institute

Research Focus

The main focus of our work is the development of novel biomarker assays for the diagnosis and prognosis of disease, in both clinical and pre-clinical settings.

Lab technician pippettingMost assays have been developed to detect the human, rodent and bovine forms of these hormones. In addition, HPLC technology is employed to assess the kinetics and mechanisms underlying the metabolism of peptides in plasma and tissue.

The lab is well equipped with RIA, ELISA and Luminex technologies and has in vitro cell culture and ex vivo isolated heart facilities for further biodiscovery applications.

Assays that have been developed within the laboratory include;

  • atrial natriuretic peptide (ANP)
  • brain natriuretic peptide (BNP)
  • N-terminal BNP
  • c-type natriuretic peptide (CNP)
  • neutral endopeptidase activity (NEP or E.C. 24.11)
  • adrenomedullin
  • angiotensin II
  • angiotensin converting enzyme activity (ACE)
  • plasma renin activity
  • arginine vasopressin
  • ACTH
  • cortisol
  • aldosterone
  • endothelin
  • cGMP
  • cAMP
  • the catecholamines
  • Ghrelin peptides
  • signal peptide fragments derived from preproproteins


The Translational Biodiscovery Laboratory currently consists of 4 scientists and 9 technical staff, with 2 PhD students.


Research staff

Contact Details

Tel 64 3 364 0848
Fax 64 3 364 0818