The right tissue for the right patient at the right time
Lottery Health funded research project
Dr Jaydee Cabral, Principal Investigator
The aim of our study is to develop a 3D bioprinted, biodegradable, living dressing that will help heal diabetic foot ulcers and reduce the need for amputation. Our approach, ‘the right tissue for the right patient’, refers to a new, innovative way to promote wound healing by taking a personalised medicine approach using a patient’s own adult stem cells derived from bone marrow and blood, delivered in a custom 3D bioprinted scaffold to fit the shape and depth of the wound.
The Bioscaffolder provides a a flexible 3D scaffold / construct manufacturing platform offering precise x-y-z delivery of a large variety of natural or synthetic materials as well as printing of cell suspensions with up to 4 independent print heads. It is currently the only one of its kind in New Zealand.
It can 3D Print a variety of different biopolymers, create porous structures for tissue engineering, co-print hard (PCL) and soft (alginate) biopolymers, has an exposition lamp for UV curing; and can do so via sequential printing, co-axial extrusion, and nanolitre, piezoelectric pipetting.
This instrument is also equipped with Melt Electrowriting (MEW) apparatus that enables the printing of micro structures from biopolymers as well as a novel pneumatic core/shell extrusion to create hollow fibers.
Current projects utilizing the Bioscaffolder include:
- Development of 3D regenerative, vascularized skin mimics
- Bioactive synthetic scaffolds for healthcare applications
- Novel biomaterials for dental applications
- Fabrication of microelectrode arrays
- Bioprinting of 3D human skin equivalents to measure therapeutic effects of growth factors
- Investigation on the impact of the functionality of food ingredients in well-designed food matrices
Core Shell Extrusion