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Dr Jaydee Cabral

jaydee_cabralPhD (Old Dominion University & Eastern Virginia Medical School), MA and BSc (College of William & Mary)

Tel +64 3 479 4897
Location: Science II, 3n9
Email jcabral@chemistry.otago.ac.nz

Dr Cabral received her PhD in Biomedical Sciences with a concentration in Biochemistry from Eastern Virginia Medical School and Old Dominion University, USA. She was a visiting lecturer at California State University prior to her appointment as a postdoctoral fellow in the Chemistry department at the University of Otago. She was promoted to research fellow in 2011 and to Senior Research Fellow in 2018. Her research involves an interdisciplinary approach between the Health and Basic Science divisions in the development of a surgical hydrogel for the prevention of adhesion formation in ENT surgeries. The culmination of this interdisciplinary network of researchers, physicians and industry partners contributed to its commercialisation, Chitogel®.

Having received funding from a Lottery Health and a University of Otago Major Equipment grant, she obtained the latest in 3D bioprinting technology, the GeSIM 3.1 Bioscaffolder. Her current work involves the 3D bioprinting of regenerative tissue constructs for the treatment of non-healing wounds funded by an Explorer HRC grant. She is also a recent award recipient of a Lottery Health Research grant to 3D bioprint living dressings for the treatment of diabetic foot ulcers. Her repertoire of techniques, in addition to 3D bioprinting, include polymer synthesis, chemical and physical characterization techniques, microbiological analysis, in vitro tissue culture, and in vivo mouse models. In collaboration with researchers from the University of Auckland, she was also awarded a MedTech/BRNZ CoRE New Concept Project grant to develop drug delivery methods to the inner ear for the treatment of hearing loss.

Dr. Cabral collaborates with researchers nationally and internationally, as demonstrated by her publications.

Dr. Cabral is also an Associate Investigator at Medtech CoRe.

Further information on the 3D Bioscafforder

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Publications

Turner, P. R., Yoshida, M., Ali, A., & Cabral, J. D. (2020). Melt electrowitten sandwich scaffold technique using Sulforhodamine B to monitor stem cell behavior. Tissue Engineering Part C: Methods. Advance online publication. doi: 10.1089/ten.TEC.2020.0240

Turner, P. R., Murray, E., McAdam, C. J., McConnell, M. A., & Cabral, J. D. (2020). Peptide chitosan/dextran core/shell vascularized 3D constructs for wound healing. ACS Applied Materials & Interfaces, 12, 32328-32339. doi: 10.1021/acsami.0c07212

Berry-Kilgour, C., Cabral, J., & Wise, L. (2020). Advancements in the delivery of growth factors and cytokines for the treatment of cutaneous wound indications [Invited]. Advances in Wound Care. Advance online publication. doi: 10.1089/wound.2020.1183

Rajabi, M., Ali, A., McConnell, M., & Cabral, J. (2020). Keratinous materials: Structures and functions in biomedical applications. Materials Science & Engineering: C, 110, 110612. doi: 10.1016/j.msec.2019.110612

Hewitt, E., Mros, S., McConnell, M., Cabral, J. D., & Ali, A. (2019). Melt-electrowriting with novel milk protein/PCL biomaterials for skin regeneration. Biomedical Materials, 14, 055013. doi: 10.1088/1748-605X/ab3344

Other Research Output

Cabral, J. (2018, September). Wound healing biomaterials as post-surgical aides: 3D bioinks and drug release delivery vehicles. Department of Microbiology & Immunology, University of Otago, Dunedin, New Zealand. [Department Seminar].

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Chapter in Book - Research

Moratti, S. C., & Cabral, J. D. (2017). Antibacterial properties of chitosan. In J. A. Jennings & J. D. Bumgardner (Eds.), Chitosan based biomaterials (Vol. 1: Fundamentals). (pp. 31-44). Elsevier. doi: 10.1016/B978-0-08-100230-8.00002-9

Cabral, J. D. (2016). Antimicrobial polymeric hydrogels. In S. Kalia (Ed.), Polymeric hydrogels as smart biomaterials. (pp. 153-170). Cham, Switzerland: Springer. doi: 10.1007/978-3-319-25322-0_6

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Journal - Research Article

Turner, P. R., Yoshida, M., Ali, A., & Cabral, J. D. (2020). Melt electrowitten sandwich scaffold technique using Sulforhodamine B to monitor stem cell behavior. Tissue Engineering Part C: Methods. Advance online publication. doi: 10.1089/ten.TEC.2020.0240

Turner, P. R., Murray, E., McAdam, C. J., McConnell, M. A., & Cabral, J. D. (2020). Peptide chitosan/dextran core/shell vascularized 3D constructs for wound healing. ACS Applied Materials & Interfaces, 12, 32328-32339. doi: 10.1021/acsami.0c07212

Hewitt, E., Mros, S., McConnell, M., Cabral, J. D., & Ali, A. (2019). Melt-electrowriting with novel milk protein/PCL biomaterials for skin regeneration. Biomedical Materials, 14, 055013. doi: 10.1088/1748-605X/ab3344

Intini, C., Elviri, L., Cabral, J., Mros, S., Bergonzi, C., Bianchera, A., … McConnell, M. (2018). 3D-printed chitosan-based scaffolds: An in vitro study of human skin cell growth and an in-vivo wound healing evaluation in experimental diabetes in rats. Carbohydrate Polymers, 199, 593-602. doi: 10.1016/j.carbpol.2018.07.057

Nelson, V. J., Dinnunhan, M. F. K., Turner, P. R., Faed, J. M., & Cabral, J. D. (2017). A chitosan/dextran-based hydrogel as a delivery vehicle of human bone-marrow derived mesenchymal stem cells. Biomedical Materials, 12(3), 035012. doi: 10.1088/1748-605X/aa70f2

Ghosh, S., Cabral, J. D., Hanton, L. R., & Moratti, S. C. (2016). Strong poly(ethylene oxide) based gel adhesives via oxime cross-linking. Acta Biomaterialia, 29, 206-214. doi: 10.1016/j.actbio.2015.10.018

Jalalvandi, E., Cabral, J., Hanton, L. R., & Moratti, S. C. (2016). Cyclodextrin-polyhydrazine degradable gels for hydrophobic drug delivery. Materials Science & Engineering: C, 69, 144-153. doi: 10.1016/j.msec.2016.06.058

Cabral, J. D., McConnell, M. A., Fitzpatrick, C., Mros, S., Williams, G., Wormald, P. J., Moratti, S. C., & Hanton, L. R. (2015). Characterization of the in vivo host response to a bi-labeled chitosan-dextran based hydrogel for postsurgical adhesion prevention. Journal of Biomedical Materials Research Part A, 103(8), 2611-2620. doi: 10.1002/jbm.a.35395

Aziz, M. A., Cabral, J. D., Brooks, H. J. L., McConnell, M. A., Fitzpatrick, C., Hanton, L. R., & Moratti, S. C. (2015). In vitro biocompatibility and cellular interactions of a chitosan/dextran-based hydrogel for postsurgical adhesion prevention. Journal of Biomedical Materials Research Part B, 103(2), 332-341. doi: 10.1002/jbm.b.33206

Chan, M., Brooks, H. J. L., Moratti, S. C., Hanton, L. R., & Cabral, J. D. (2015). Reducing the oxidation level of dextran aldehyde in a chitosan/dextran-based surgical hydrogel increases biocompatibility and decreases antimicrobial efficacy. International Journal of Molecular Sciences, 16(6), 13798-13814. doi: 10.3390/ijms160613798

Cabral, J. D., Roxburgh, M., Shi, Z., Liu, L., McConnell, M., Williams, G., … Hanton, L. R., Simpson, J., Moratti, S. C., Robinson, B. H., … Robinson, S. (2014). Synthesis, physiochemical characterization, and biocompatibility of a chitosan/dextran-based hydrogel for postsurgical adhesion prevention. Journal of Materials Science: Materials in Medicine, 25(12), 2743-2756. doi: 10.1007/s10856-014-5292-3

Cabral, J. D., & Moratti, S. C. (2012). Advances in biomedical hydrogels. Chemistry in New Zealand, 76(2), 44-48.

Aziz, M. A., Cabral, J. D., Brooks, H. J. L., Moratti, S. C., & Hanton, L. R. (2012). Antimicrobial properties of a chitosan dextran-based hydrogel for surgical use. Antimicrobial Agents & Chemotherapy, 56(1), 280-287. doi: 10.1128/aac.05463-11

Cabral, J., & Moratti, S. C. (2011). Hydrogels for biomedical applications. Future Medicinal Chemistry, 3(15), 1877-1888. doi: 10.4155/fmc.11.134

Valentine, R., Boase, S., Jervis-Bardy, J., Cabral, J.-D. D., Robinson, S., & Wormald, P.-J. (2011). The efficacy of hemostatic techniques in the sheep model of carotid artery injury. International Forum of Allergy & Rhinology, 1(2), 118-122. doi: 10.1002/alr.20033

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Journal - Research Other

Berry-Kilgour, C., Cabral, J., & Wise, L. (2020). Advancements in the delivery of growth factors and cytokines for the treatment of cutaneous wound indications [Invited]. Advances in Wound Care. Advance online publication. doi: 10.1089/wound.2020.1183

Rajabi, M., Ali, A., McConnell, M., & Cabral, J. (2020). Keratinous materials: Structures and functions in biomedical applications. Materials Science & Engineering: C, 110, 110612. doi: 10.1016/j.msec.2019.110612

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Conference Contribution - Published proceedings: Abstract

Cabral, J. D., Aziz, M. A., Moratti, S. C., Brooks, H., Hanton, L. R., & Boissezon, R. (2012). Physical characterization and biocompatibility of a chitosan/dextran-based hydrogel for surgical use. Proceedings of the 243rd American Chemical Society (ACS) National Meeting & Exposition. Retrieved from http://www.acs.org/content/acs/en/meetings/nationalmeetings/programarchive.html

Cabral, J., Moratti, S., Hanton, L., Aziz, M., Kirchhoefer, C., Bork, O., & Brooks, H. (2010). Drug release studies and biological properties of chitosan/dextran-based hydrogels for surgical use. Proceedings of the International Chemical Congress of Pacific Basin Societies (Pacifichem). Retrieved from http://pacifichem.abstractcentral.com/planner

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Conference Contribution - Verbal presentation and other Conference outputs

Cabral, J. D., Murray, E., Turner, P., & Wise, L. (2019, August-September). Wound healing biomaterials as cell and drug delivery vehicles. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Yoshida, M., Ali, A., & Cabral, J. (2019, August-September). Development and in vitro biocompatibility of 3D printed scaffolds for intervertebral disc tissue engineering. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Cabral, J. (2018, April). Biomaterials for cell therapy. Verbal presentation at the University of Otago Centre for Bioengineering & Nanomedicine Symposium: Biomaterials and Regenerative Medicine, Dunedin, New Zealand.

Cabral, J. D., Nelson, V., Faed, J., Hanton, L., & Moratti, S. (2016, August-September). Development and characterization of chitosan/dextran-based hydrogels for adult stem cell delivery. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.

Cabral, J., Hanton, L., Moratti, S., McConnell, M., Fitzpatrick, C., & Mros, S. (2014, November). In vivo biodistribution, biodegradation, and inflammatory response of a NIR/[3H]-chitosan/dextran-based hydrogel for post-surgical adhesion prevention. Verbal presentation at the Devices for Diagnostics and Drug Delivery (D4) Conference, Dunedin, New Zealand.

Cabral, J. (2013, December). In vitro and in vivo biocompatibility of a chitosan/dextran-based surgical hydrogel. Verbal presentation at the 12th International Conference on Frontiers of Polymers and Advanced Materials (ICFPAM), Auckland, New Zealand.

Cabral, J. (2013, October). In vitro and in vivo biocompatibility of a chitosan/dextran-based surgical hydrogel. Verbal presentation at the Polymers in Medicine and Biology Conference, Santa Rosa, CA.

McConnell, M. A., Brooks, H. J., Moratti, S. C., Hanton, L. R., & Cabral, J. D. (2013, July). In vitro and in vivo biocompatibility of a chitosan/dextan-based surgical hydrogel. Plenary presentation at the ChemEd Conference, Dunedin, New Zealand.

Cabral, J. D., Aziz, M. A., McConnell, M. A., Brooks, H. J., Williams, G., Hanton, L. R., & Moratti, S. C. (2012, October). Characterization of chitosan/dextran-based surgical hydrogel. Verbal presentation at the International Union of Pure and Applied Chemistry (IUPAC) 8th International Conference on Novel Materials and their Synthesis (NMS-VIII) & 22nd International Symposium on Fine Chemistry and Functional Polymers (FCFP-XXII), Xi'an, China.

Aziz, M., Moratti, S., Brooks, H., Hanton, L., & Cabral, J. (2011, November). Antimicrobial properties of chitosan/dextran based hydrogels for surgical use. Verbal presentation at the 3rd Biohydrogels International Congress, Florence, Italy.

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