Professor Geoffrey Shaw, Our people, University of Otago, Christchurch, University of Otago, New Zealand

Clinical Professor

MB ChB FANZCA FCICM Hon FIPENZ

Geoff is an intensive care specialist and Professor of Intensive Care at the University of Otago, Christchurch and an Adjunct Professor in the Department of Mechanical Engineering, University of Canterbury.

He is also the first clinician to be made an honorary fellow of the Institute of Professional Engineers of New Zealand.

Research Interests

Include:

Modelling and control of agitation-sedation
Insulin-glucose dynamics
Cardiovascular dynamics
Acute respiratory distress syndrome (ARDS) in critically ill patients

Other interests

Include:

Arguing why evidence based medicine might be bad for you
Building sundials
Cosmology

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Publications

Vlasiuk, E., Rosengrave, P., Roberts, E., Boden, J. M., Shaw, G., & Carr, A. C. (2022). Critically ill septic patients have elevated oxidative stress biomarkers: Lack of attenuation by parenteral vitamin C. Nutrition Research. Advance online publication. doi: 10.1016/j.nutres.2022.10.010

Lamontagne, F., Masse, M.-H., Menard, J., Sprague, S., Pinto, R., Heyland, D. K., … Twardowski, P., … for the LOVIT Investigators, and the Canadian Critical Care Trials Group, including Shaw, G., Burke, B., Henderson, S., Hitchings, L., Smith, M., Waibel, H. A., Moore, J., Psirides, A., Tietjens, K., & Ure, B. (2022). Intravenous vitamin C in adults with sepsis in the intensive care unit. New England Journal of Medicine, 386(25), 2387-2398. doi: 10.1056/NEJMoa2200644

Adhikari, N. K. J., Pinto, R., Day, A. G., Masse, M.-H., Ménard, J., Sprague, S., … Twardowski, P., … LOVIT Investigators, including Shaw, G. (2022). Lessening Organ Dysfunction With Vitamin C (LOVIT) trial: Statistical analysis plan. JMIR Research Protocols, 11(5), e36261. doi: 10.2196/36261

Rosengrave, P., Spencer, E., Williman, J., Mehrtens, J., Morgan, S., Doyle, T., Van Der Heyden, K., … Shaw, G., & Carr, A. C. (2022). Intravenous vitamin C administration to patients with septic shock: A pilot randomised controlled trial. Critical Care, 26(1), 26. doi: 10.1186/s13054-022-03900-w

Spencer, E., Rosengrave, P., Williman, J., Shaw, G., & Carr, A. C. (2022). Circulating protein carbonyls are specifically elevated in critically ill patients with pneumonia relative to other sources of sepsis. Free Radical Biology & Medicine, 179, 208-212. doi: 10.1016/j.freeradbiomed.2021.11.029

Chase, J. G., Benyo, B., Desaive, T., Fisk, L., Dickson, J. L., Penning, S., … Shaw, G. M. (2013). Uncertainty, safety, and performance: A generalizable approach to risk- based (therapeutic) decision making. In A. Agah (Ed.), Medical applications of artificial intelligence. (pp. 233-246). Boca Raton, FL: CRC Press.

Chapter in Book - Research

Shaw, G. M. (2000). High frequency ventilation: The quest to minimise lung injury. In Australasian Anaesthesia. (pp. 181-190). Australian and New Zealand College of Anaesthetists.

Chapter in Book - Other

Journal - Research Article

Balmer, J., Smith, R., Pretty, C. G., Desaive, T., Shaw, G. M., & Chase, J. G. (2021). Accurate end systole detection in dicrotic notch-less arterial pressure waveforms. Journal of Clinical Monitoring & Computing, 35(1), 79-88. doi: 10.1007/s10877-020-00473-3

Journal - Research Article

Carr, A. C., Bozonet, S., Pullar, J., Spencer, E., Rosengrave, P., & Shaw, G. (2021). Neutrophils isolated from septic patients exhibit elevated uptake of vitamin C and normal intracellular concentrations despite a low vitamin C milieu. Antioxidants, 10(10), 1607. doi: 10.3390/antiox10101607

Journal - Research Article

Parente, J. D., Chase, J. G., Moeller, K., & Shaw, G. M. (2021). High inter-patient variability in sepsis evolution: A hidden Markov model analysis. Computer Methods & Programs in Biomedicine, 201, 105956. doi: 10.1016/j.cmpb.2021.105956

Journal - Research Article

Uyttendaele, V., Chase, J. G., Knopp, J. L., Gottlieb, R., Shaw, G. M., & Desaive, T. (2021). Insulin sensitivity in critically ill patients: are women more insulin resistant? Annals of Intensive Care, 11, 12. doi: 10.1186/s13613-021-00807-7

Journal - Research Article

Balmer, J., Pretty, C. G., Davidson, S., Mehta-Wilson, T., Desaive, T., Smith, R., Shaw, G. M., & Chase, J. G. (2020). Clinically applicable model-based method, for physiologically accurate flow waveform and stroke volume estimation. Computer Methods & Programs in Biomedicine, 185, 105125. doi: 10.1016/j.cmpb.2019.105125

Journal - Research Article

Baxter-Parker, G., Gaddam, R. R., Moltchanova, E., Carr, A. C., Shaw, G., Chambers, S., & Gieseg, S. P. (2020). Oxidative stress and immune cell activation quantification in sepsis and non-sepsis critical care patients by neopterin/7,8-dihydroneopterin analysis. Pteridines, 31(1), 68-82. doi: 10.1515/pteridines-2020-0015

Journal - Research Article

Carr, A. C., Spencer, E., Hoskin, T. S., Rosengrave, P., Kettle, A. J., & Shaw, G. (2020). Circulating myeloperoxidase is elevated in septic shock and is associated with systemic organ failure and mortality in critically ill patients. Free Radical Biology & Medicine, 152, 462-468. doi: 10.1016/j.freeradbiomed.2019.11.004

Journal - Research Article

Chase, J. G., Chiew, Y. S., Lambermont, B., Morimont, P., Shaw, G. M., & Desaive, T. (2020). Safe doubling of ventilator capacity: A last resort proposal for last resorts. Critical Care, 24, 222. doi: 10.1186/s13054-020-02945-z

Journal - Research Article

Howe, S. L., Chase, J. G., Redmond, D. P., Morton, S. E., Kim, K. T., Shaw, G. M., … Desaive, T. (2020). Inspiratory respiratory mechanics estimation by using expiratory data for reverse-trigger breathing cycles. Computer Methods & Programs in Biomedicine, 186, 105184. doi: 10.1016/j.cmpb.2019.105184

Journal - Research Article

Parente, J. D., Chase, J. G., Moeller, K., & Shaw, G. M. (2020). Quantifying misclassification and bias errors due to hierarchical sepsis scores in real-time sepsis diagnosis. Biomedical Signal Processing & Control, 62, 102116. doi: 10.1016/j.bspc.2020.102116

Journal - Research Article

Parente, J. D., Chase, J. G., Möller, K., & Shaw, G. M. (2020). Kernel density estimates for sepsis classification. Computer Methods & Programs in Biomedicine, 188, 105295. doi: 10.1016/j.cmpb.2019.105295

Journal - Research Article

Uyttendaele, P., Knopp, J. L., Shaw, G. M., Desaive, T., & Chase, J. G. (2020). Risk and reward: Extending stochastic glycaemic control intervals to reduce workload. BioMedical Engineering OnLine, 19, 26. doi: 10.1186/s12938-020-00771-6

Journal - Research Article

Knopp, J. L., Lynn, A. M., Shaw, G. M., & Chase, J. G. (2019). Safe and effective glycaemic control in premature infants: Observational clinical results from the computerised STAR-GRYPHON protocol. Archives of Disease in Childhood: Fetal & Neonatal Edition, 104(2), F205-F211. doi: 10.1136/archdischild-2017-314072

Journal - Research Article

Morton, S. E., Knopp, J. L., Chase, J. G., Möller, K., Docherty, P., Shaw, G. M., & Tawhai, M. (2019). Predictive virtual patient modelling of mechanical ventilation: Impact of recruitment function. Annals of Biomedical Engineering, 47(7), 1626-1641. doi: 10.1007/s10439-019-02253-w

Journal - Research Article

Uyttendaele, V., Knopp, J. L., Davidson, S., Desaive, T., Benyo, B., Shaw, G. M., & Chase, J. G. (2019). 3D kernel-density stochastic model for more personalized glycaemic control: Development and in-silico validation. BioMedical Engineering OnLine, 18, 102. doi: 10.1186/s12938-019-0720-8

Journal - Research Article

Uyttendaele, V., Knopp, J. L., Shaw, G. M., Desaive, T., & Chase, J. G. (2019). Is intensive insulin therapy the scapegoat for or cause of hypoglycaemia and poor outcome. IFAC Journal of Systems and Control, 9, 100063. doi: 10.1016/j.ifacsc.2019.100063

Journal - Research Article

Balmer, J., Pretty, C., Davidson, S., Desaive, T., Kamoi, S., Pironet, A., … Shaw, G. M., & Chase, J. G. (2018). Pre-ejection period, the reason why the electrocardiogram Q-wave is an unreliable indicator of pulse wave initialization. Physiological Measurement, 39(9), 095005. doi: 10.1088/1361-6579/aada72

Journal - Research Article

Chase, J. G., Preiser, J.-C., Dickson, J. L., Pironet, A., Chiew, Y. S., Pretty, C. G., Shaw, G. M., … Desaive, T. (2018). Next-generation, personallsed model-based critical care medicine: A state-of-the-art review of in silico virtual patient models, methods and cohorts, and how to validate them. BioMedical Engineering OnLine, 17, 24. doi: 10.1186/s12938-018-0455-y

Journal - Research Article

Dickson, J. L., Stewart, K. W., Pretty, C. G., Flechet, M., Desaive, T., Penning, S., … Shaw, G. M., & Chase, J. G. (2018). Generalisability of a virtual trials method for glycaemic control in intensive care. IEEE Transactions on Biomedical Engineering, 65(7), 1543-1553. doi: 10.1109/TBME.2017.2686432

Journal - Research Article

Major, V. J., Chiew, Y. S., Shaw, G. M., & Chase, J. G. (2018). Biomedical engineer's guide to the clinical aspects of intensive care mechanical ventilation. BioMedical Engineering OnLine, 17, 169. doi: 10.1186/s12938-018-0599-9

Journal - Research Article

Morton, S. E., Dickson, J., Chase, J. G., Docherty, P., Desaive, T., Howe, S. L., Shaw, G. M., & Tawhai, M. (2018). A virtual patient model for mechanical ventilation. Computer Methods & Programs in Biomedicine, 165, 77-87. doi: 10.1016/j.cmpb.2018.08.004

Journal - Research Article

Stewart, K. W., Chase, J. G., Pretty, C. G., & Shaw, G. M. (2018). Nutrition delivery of a model-based ICU glycaemic control system. Annals of Intensive Care, 8, 4. doi: 10.1186/s13613-017-0351-9

Journal - Research Article

Stewart, K. W., Chase, J. G., Pretty, C. G., & Shaw, G. M. (2018). Nutrition delivery, workload and performance in a model-based ICU glycaemic control system. Computer Methods & Programs in Biomedicine, 166, 9-18. doi: 10.1016/j.cmpb.2018.09.005

Journal - Research Article

Stewart, K. W., Pretty, C. G., Shaw, G. M., & Chase, J. G. (2018). Creating smooth SI. B-spline basis function representations of insulin sensitivity. Biomedical Signal Processing & Control, 44, 270-278. doi: 10.1016/j.bspc.2018.05.001

Journal - Research Article

Stewart, K. W., Pretty, C. G., Shaw, G. M., & Chase, J. G. (2018). Interpretation of retrospective BG measurements. Journal of Diabetes Science & Technology, 12(5), 967-975. doi: 10.1177/1932296818786518

Journal - Research Article

Uyttendaele, V., Knopp, J. L., Stewart, K. W., Desaive, T., Benyó, B., Szabó-Némedi, N., … Shaw, G. M., & Chase, J. G. (2018). A 3D insulin sensitivity prediction model enables more patient-specific prediction and model-based glycaemic control. Biomedical Signal Processing & Control, 46, 192-200. doi: 10.1016/j.bspc.2018.05.032

Journal - Research Article

Zhou, T., Dickson, J. L., Shaw, G. M., & Chase, J. G. (2018). Continuous glucose monitoring measures can be used for glycemic control in the ICU: An in-silico study. Journal of Diabetes Science & Technology, 12(1), 7-19. doi: 10.1177/1932296817738791

Journal - Research Article

Carr, A. C., Rosengrave, P. C., Bayer, S., Chambers, S., Mehrtens, J., & Shaw, G. M. (2017). Hypovitaminosis C and vitamin C deficiency in critically ill patients despite recommended enteral and parenteral intakes. Critical Care, 21, 300. doi: 10.1186/s13054-017-1891-y

Journal - Research Article

Dickson, J. L., Chase, J. G., Lynn, A., & Shaw, G. M. (2017). Model-based glycaemic control: Methodology and initial results from neonatal intensive care. Biomedical Engineering / Biomedizinische Technik, 62(2), 225-233. doi: 10.1515/bmt-2016-0051

Journal - Research Article

Gaddam, R. R., Chambers, S., Murdoch, D., Shaw, G., & Bhatia, M. (2017). Circulating levels of hydrogen sulfide and substance P in patients with sepsis. Journal of Infection, 75(4), 293-300. doi: 10.1016/j.jinf.2017.07.005

Journal - Research Article

Kamoi, S., Pretty, C., Balmer, J., Davidson, S., Pironet, A., Desaive, T., Shaw, G. M., & Chase, J. G. (2017). Improved pressure contour analysis for estimating cardiac stroke volume using pulse wave velocity measurement. BioMedical Engineering OnLine, 16, 51. doi: 10.1186/s12938-017-0341-z

Journal - Research Article

Khan, M., Pretty, C. G., Amies, A. C., Balmer, J., Banna, H. E., Shaw, G. M., & Chase, J. G. (2017). Proof of concept non-invasive estimation of peripheral venous oxygen saturation. BioMedical Engineering OnLine, 16, 60. doi: 10.1186/s12938-017-0351-x

Journal - Research Article

Morton, S. E., Chiew, Y. S., Pretty, C., Moltchanova, E., Scarrott, C., Redmond, D., Shaw, G. M., & Chase, J. G. (2017). Effective sample size estimation for a mechanical ventilation trial through Monte-Carlo simulation: Length of mechanical ventilation and ventilator free days. Mathematical Biosciences, 4, 21-31. doi: 10.1016/j.mbs.2016.06.001

Journal - Research Article

Kelly, H. E., Shaw, G. M., Brett, C. N., Greenwood, F. M., & Huckabee, M. L. (2016). The effect of titrated fentanyl on suppressed cough reflex in healthy adult volunteers. Anaesthesia, 71, 529-534. doi: 10.1111/anae.13410

Journal - Research Article

Khan, M., Pretty, C. G., Amies, A. C., Elliott, R., Chiew, Y. S., Shaw, G. M., & Chase, J. G. (2016). Analysing the effects of cold, normal, and warm digits on transmittance pulse oximetry. Biomedical Signal Processing & Control, 26, 34-41. doi: 10.1016/j.bspc.2015.12.006

Journal - Research Article

Lindsay, A., Bernard, A., Davidson, S. M., Redmond, D. P., Chiew, Y. S., Pretty, C., … Shaw, G. M., Gieseg, S. P., & Draper, N. (2016). Lung injury and respiratory mechanics in rugby union. Journal of Sports Medicine & Physical Fitness, 56(4), 450-457.

Journal - Research Article

Stewart, K. W., Pretty, C. G., Tomlinson, H., Thomas, F. L., Homlok, J., Némedi Noémi, S., … Shaw, G. M., … Chase, J. G. (2016). Safety, efficacy and clinical generalization of the STAR protocol: A retrospective analysis. Annals of Intensive Care, 6, 24. doi: 10.1186/s13613-016-0125-9

Journal - Research Article

Carr, A. C., Shaw, G. M., Fowler, A. A., & Natarajan, R. (2015). Ascorbate-dependent vasopressor synthesis: A rationale for vitamin C administration in severe sepsis and septic shock? Critical Care, 19, 418. doi: 10.1186/s13054-015-1131-2

Journal - Research Article

Chiew, Y. S., Pretty, C., Docherty, P. D., Lambermont, B., Shaw, G. M., Desaive, T., & Chase, J. G. (2015). Time-varying respiratory system elastance: A physiological model for patients who are spontaneously breathing. PLoS ONE, 10(1), e0114847. doi: 10.1371/journal.pone.0114847

Journal - Research Article

Penning, S., Pretty, C., Preiser, J.-C., Shaw, G. M., Desaive, T., & Chase, J. G. (2015). Glucose control positively influences patient outcome: A retrospective study. Journal of Critical Care, 30, 455-459. doi: 10.1016/j.jcrc.2014.12.013

Journal - Research Article

Stewart, K. W., Pretty, C. G., Tomlinson, H., Fisk, L., Shaw, G. M., & Chase, J. G. (2015). Stochastic Model Predictive (STOMP) glycaemic control for the intensive care unit: Development and virtual trial validation. Biomedical Signal Processing & Control, 16, 61-67. doi: 10.1016/j.bspc.2014.09.011

Journal - Research Article

Young, P., Saxena, M., Bellomo, R., Freebairn, R., Hammond, N., van Haren, F., … Henderson, S., … Weatherall, M., … Beasley, R., for the HEAT Investigators, and the Australian and New Zealand Intensive Care Society Clinical Trials Group, including Shaw, G., Bailey, M., & Psirides, A. (2015). Acetaminophen for fever in critically ill patients with suspected infection. New England Journal of Medicine, 373, 2215-2224. doi: 10.1056/NEJMoa1508375

Journal - Research Article

Kamoi, S., Pretty, C., Docherty, P., Squire, D., Revie, J., Chiew, Y. S., … Shaw, G. M., & Chase, J. G. (2014). Continuous stroke volume estimation from aortic pressure using zero dimensional cardiovascular model: Proof of concept study from porcine experiments. PLoS ONE, 9(7), e102476. doi: 10.1371/journal.pone.0102476

Journal - Research Article

Pretty, C. G., Le Compte, A., Penning, S., Fisk, L., Shaw, G. M., Desaive, T., & Chase, J. G. (2014). Interstitial insulin kinetic parameters for a 2-compartment insulin model with saturable clearance. Computer Methods & Programs in Biomedicine, 114(3), e39-e45. doi: 10.1016/j.cmpb.2014.01.011

Journal - Research Article

More publications...

Professor Geoff Shaw

Research Interests

Other interests

Publications