BSc(Cant) MSc(Cant) PhD(Otago)
Email chris.charles@otago.ac.nz
Christchurch Heart Institute
Department of Medicine
University of Otago, Christchurch
PO Box 4345
Christchurch 8140
New Zealand
Current roles
- Research Professor Christchurch Heart Institute
- Co-Director, Physiology Division, Christchurch Heart Institute
- Named Investigator, HRC Programme Grant
- Concurrent appointment with Cardiovascular Research Institute (CVRI), National University Singapore
Research interests
- Integrative cardiovascular, endocrine and renal physiology of pressure / volume homeostasis
- Bioactivity of vasoactive hormones including natriuretic peptides, adrenomedullins and urocortins
- Pathophysiology of myocardial infarction, heart failure and sudden cardiac death
Professional memberships / roles
- 2008-present, Executive Council and Treasurer, NZ Society Medical Sciences (MedSci)
Inaugural Professorial Lecture
Heart Hormones in Health and Disease: A Hearty Professor's Perspective
Publications
Wong, L. L., Fadzil, A. B., Chen, Q., Rademaker, M. T., Charles, C. J., Richards, A. M., & Wang, P. (2023). Interrogating the role of miR-125b and its 3’isomiRs in protection against hypoxia. International Journal of Molecular Sciences, 24, 16015. doi: 10.3390/ijms242116015 Journal - Research Article
Rademaker, M. T., Scott, N. J. A., Charles, C. J., & Richards, A. M. (2023). Combined inhibition of phosphodiesterases 5 and 9 in experimental heart failure. JACC: Heart Failure. Advance online publication. doi: 10.1016/j.jchf.2023.08.028 Journal - Research Article
Tian, X., Zeng, Q., Kurt, S. A., Li, R. R., Nguyen, D. T., Xiong, Z., … Charles, C. J., & Ho, J. S. (2023). Implant-to-implant wireless networking with metamaterial textiles. Nature Communications, 14, 4335. doi: 10.1038/s41467-023-39850-2 Journal - Research Article
Templeton, E. M., Pilbrow, A. P., Kleffmann, T., Pickering, J. W., Rademaker, M. T., Scott, N. J. A., Ellmers, L. J., Charles, C. J., Endre, Z. H., Richards, A. M., Cameron, V. A., & Lassé, M. (2023). Comparison of SPEED, S-Trap, and in-solution-based sample preparation methods for mass spectrometry in kidney tissue and plasma. International Journal of Molecular Sciences, 24(7), 6290. doi: 10.3390/ijms24076290 Journal - Research Article
Scott, N. J. A., Prickett, T. C. R., Charles, C. J., Frampton, C. M., Richards, A. M., & Rademaker, M. T. (2023). Augmentation of natriuretic peptide bioactivity via combined inhibition of neprilysin and phosphodiesterase-9 in heart failure. JACC: Heart Failure. Advance online publication. doi: 10.1016/j.jchf.2022.11.006 Journal - Research Article
Lim, X. C., Huang, C., Yatim, S. M. J. M., Chong, S. Y., Tan, S. H., Yang, X., … Richards, A. M., Charles, C. J., … Wang, J.-W. (2023). Temporal changes in extracellular vesicle hemostatic protein composition predict favourable left ventricular remodeling after acute myocardial infarction. International Journal of Molecular Sciences, 24, 327. doi: 10.3390/ijms24010327 Journal - Research Article
Weissmann, J., Charles, C. J., Richards, A. M., Yap, C. H., & Marom, G. (2022). Material property alterations for phenotypes of heart failure with preserved ejection fraction: A numerical study of subject-specific porcine models. Frontiers in Bioengineering & Biotechnology, 10, 1032034. doi: 10.3389/fbioe.2022.1032034 Journal - Research Article
Zheng, Y., Chan, W. X., Charles, C. J., Richards, A. M., Lee, L. C., Leo, H. L., & Yap, C. H. (2022). Morphological, functional, and biomechanical progression of LV remodelling in a porcine model of HFpEF. Journal of Biomechanics, 144, 111348. doi: 10.1016/j.jbiomech.2022.111348 Journal - Research Article
Templeton, E., Lassé, M., Cameron, V., Pickering, J., Kleffmann, T., Hertzberg, D., Frampton, C., Ellmers, L., Palmer, S., … Scott, N., Charles, C., … Richards, M., … Troughton, R., Rademaker, M., & Pilbrow, A. (2022). Harnessing the power of 'Omics': Discovering novel microRNA and protein biomarkers of acute kidney injury in acute heart failure. Heart, Lung & Circulation, 31(Suppl. 2), (pp. S23-S24). doi: 10.1016/j.hlc.2022.05.009 Conference Contribution - Published proceedings: Abstract
Zheng, Y., Chan, W. X., Charles, C. J., Richards, A. M., Sampath, S., Ali, A. A. B., … Yap, C. H. (2022). Effects of hypertrophic and dilated cardiac geometric remodeling on ejection fraction. Frontiers in Physiology, 13, 898775. doi: 10.3389/fphys.2022.898775 Journal - Research Article
Li, D., Tian, K., Guo, J., Wang, Q., Qin, Z., Lu, Y., … Scott, N., Charles, C. J., … Cui, X., & Tang, J. (2022). Growth factors: Avenues for the treatment of myocardial infarction and potential delivery strategies. Regenerative Medicine, 17(8), 561-579. doi: 10.2217/rme-2022-0007 Journal - Research Other
Ong, C. W., Kumar, G. P., Zuo, K., Koh, L. B., Charles, C. J., Ho, P., … Cui, F. (2022). A novel coating method to reduce membrane infolding through pre-crimping of covered stents: Computational and experimental evaluation. Computers in Biology & Medicine, 145, 105524. doi: 10.1016/j.compbiomed.2022.105524 Journal - Research Article
Templeton, E. M., Lassé, M., Kleffmann, T., Ellmers, L. J., Palmer, S. C., Davidson, T., Scott, N. J. A., Pickering, J. W., Charles, C. J., Endre, Z. H., Cameron, V. A., Richards, A. M., Rademaker, M. T., & Pilbrow, A. P. (2022). Identifying candidate protein markers of acute kidney injury in acute decompensated heart failure. International Journal of Molecular Sciences, 23, 1009. doi: 10.3390/ijms23021009 Journal - Research Article
Weissmann, J., Charles, C. J., Richards, A. M., Yap, C. H., & Marom, G. (2022). Cardiac mesh morphing method for finite element modeling of heart failure with preserved ejection fraction. Journal of the Mechanical Behavior of Biomedical Materials, 126, 104937. doi: 10.1016/j.jmbbm.2021.104937 Journal - Research Article
Lu, Y., Cui, X., Zhang, L., Wang, X., Xu, Y., Qin, Z., … Lim, K. S., Charles, C. J., … Tang, J. (2022). The functional role of lipoproteins in atherosclerosis: Novel directions for diagnosis and targeting therapy. Aging & Disease, 13(2), 491-520. doi: 10.14336/AD.2021.0929 Journal - Research Article
Templeton, E., Lassé, M., Kleffmann, T., Ellmers, L. J., Palmer, S. C., Davidson, T., Scott, N. J., Pickering, J. W., Charles, C. J., Endre, Z. H., Cameron, V. A., & Richards, A. M. (2021). Identifying candidate protein markers of acute kidney injury in acute decompensated heart failure. Heart, Lung & Circulation, 30(Suppl. 2), (pp. S66). doi: 10.1016/j.hlc.2021.05.020 Conference Contribution - Published proceedings: Abstract
Kalidasan, V., Yang, X., Xiong, Z., Li, R. R., Yao, H., Godaba, H., … Charles, C. J., & Ho, J. S. (2021). Wirelessly operated bioelectronic sutures for the monitoring of deep surgical wounds. Nature Biomedical Engineering, 5(10), 1217-1227. doi: 10.1038/s41551-021-00802-0 Journal - Research Article
Rademaker, M. T., Pilbrow, A. P., Ellmers, L. J., Palmer, S. C., Davidson, T., Mbikou, P., Scott, N. J. A., Permina, E., Charles, C. J., Endre, Z. H., & Richards, A. M. (2021). Acute decompensated heart failure and the kidney: Physiological, histological and transcriptomic responses to development and recovery. Journal of the American Heart Association, 10, e021312. doi: 10.1161/jaha.121.021312 Journal - Research Article
Charles, C. J., Li, R. R., Yeung, T., Mazlan, S. M. I., Lai, R. C., de Kleijn, D. P. V., … Richards, A. M. (2020). Systemic mesenchymal stem cell-derived exosomes reduce myocardial infarct size: Characterization with MRI in a porcine model. Frontiers in Cardiovascular Medicine, 7, 601990. doi: 10.3389/fcvm.2020.601990 Journal - Research Article
Charles, C. J., Rademaker, M. T., Scott, N. J. A., & Richards, A. M. (2020). Large animal models of heart failure: Reduced vs. preserved ejection fraction. Animals, 10, 1906. doi: 10.3390/ani10101906 Journal - Research Other
Charles, C. J., Lee, P., Li, R. R., Yeung, T., Ibraham Mazlan, S. M., Tay, Z. W., … Richards, A. M. (2020). A porcine model of heart failure with preserved ejection fraction: Magnetic resonance imaging and metabolic energetics. ESC Heart Failure, 7, 93-103. doi: 10.1002/ehf2.12536 Journal - Research Article
Mbikou, P., Rademaker, M. T., Charles, C. J., Richards, M. A., & Pemberton, C. J. (2020). Cardiovascular effects of DWORF (dwarf open reading frame) peptide in normal and ischaemia/reperfused isolated rat hearts. Peptides, 124, 170192. doi: 10.1016/j.peptides.2019.170192 Journal - Research Article
Charles, C. J., Lee, P., Li, R. R., Yeung, T., Mazlan, S. M. I., Tay, Z. W., … Richards, A. M. (2019, September). A porcine model of heart failure with preserved ejection fraction: Characterization with MRI metabolic energetics. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Scott, N. J. A., Rademaker, M. T., Charles, C. J., Espiner, E. A., & Richards, A. M. (2019). Hemodynamic, hormonal, and renal actions of phosphodiesterase-9 inhibition in experimental heart failure. JACC, 74(7), 889-901. doi: 10.1016/j.jacc.2019.05.067 Journal - Research Article
Charles, C. J., Jardine, D. L., Rademaker, M. T., & Richards, A. M. (2019). Adrenomedullin 2 increases cardiac sympathetic nerve activity in parallel to heart rate in normal conscious sheep. Physiological Reports, 7(10), e14096. doi: 10.14814/phy2.14096 Journal - Research Article
Mbikou, P. P., Pemberton, C. J., Charles, C. J., & Rademaker, M. T. (2018, August). Characterising the role and the therapeutic potential of novel peptide DWORF in heart disease. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)
Charles, C. J., Jardine, D. L., Rademaker, M. T., & Richards, A. M. (2018). Systemic Angiotensin II does not increase cardiac sympathetic nerve activity in normal conscious sheep. Bioscience Reports, 38(5), BSR20180513. doi: 10.1042/bsr20180513 Journal - Research Article
Wong, L. L., Rademaker, M. T., Saw, E. L., Lew, K. S., Ellmers, L. J., Charles, C. J., Richards, A. M., & Wang, P. (2017). Identification of novel microRNAs in the sheep heart and their regulation in heart failure. Scientific Reports, 7(1), 8250. doi: 10.1038/s41598-017-08574-x Journal - Research Article
Pemberton, C. J., Charles, C. J., & Richards, A. M. (2017). Cardiac natriuretic peptides. In J. C. Schisler, C. H. Lang & M. S. Willis (Eds.), Endocrinology of the heart in health and disease. (pp. 3-39). Elsevier. doi: 10.1016/B978-0-12-803111-7.00001-4 Chapter in Book - Research
Pemberton, C. J., Richards, A. M., Charles, C. J., & Siriwardena, M. (2016). Cardiovascular therapeutics. [Marker reference: BNPTx] (2012 8 0050843.1). China. Intellectual Property
Mbikou, P., Byers, M., Charles, C. J., Rademaker, M. T., & Pemberton, C. J. (2016, August-September). Role of B-type natriuretic signal peptide on AKT and ERK1/2 activity in myocardial rat ischemia. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)
Mbikou, P., Byers, M., Charles, C. J., Rademaker, M. T., & Pemberton, C. J. (2016, August). Role of B-type natriuretic signal peptide on AKT and ERK1/2 activity in myocardial rat ischemia. Poster session presented at the Medical Sciences Congress (MedSci), Nelson, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)
Ellmers, L. J., Rademaker, M. T., Charles, C. J., Yandle, T. G., & Richards, A. M. (2016). (PRO)renin receptor blockade ameliorates cardiac injury and remodeling and improves function after myocardial infarction. Journal of Cardiac Failure, 22(1), 64-72. doi: 10.1016/j.cardfail.2015.08.341 Journal - Research Article
Charles, C. J. (2015, August-September). Heart hormones: Physiology as the key link between discovery and translation. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Charles, C. J. (2015, August-September). How do natriuretic peptides alter sympathetic control to the heart? Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Chan, W. Y. W., Charles, C. J., Frampton, C. M., Richards, A. M., Crozier, I. G., Troughton, R. W., & Jardine, D. L. (2015). Human muscle sympathetic nerve responses to urocortin-2 in health and stable heart failure. Clinical & Experimental Pharmacology & Physiology, 42(9), 888-895. doi: 10.1111/1440-1681.12449 Journal - Research Article
Rademaker, M. T., Ellmers, L. J., Charles, C. J., & Richards, A. M. (2015). Urocortin 2 protects heart and kidney structure and function in an ovine model of acute decompensated heart failure: Comparison with dobutamine. International Journal of Cardiology, 197, 56-65. doi: 10.1016/j.ijcard.2015.06.011 Journal - Research Article
Charles, C. J., Rademaker, M. T., Melton, I. C., Gutfinger, D., Eigler, N. L., Qu, F., & Troughton, R. W. (2015). Thoracic impedance measures tissue characteristics in the vicinity of the electrodes, not intervening lung water: Implications for heart failure monitoring. Journal of Clinical Monitoring & Computing, 29(1), 65-76. doi: 10.1007/s10877-014-9570-x Journal - Research Article
Wong, L. L., Lew, K. S., Chen, Q., Rademaker, M. T., Ellmers, L. J., Charles, C. J., Richards, A. M., & Wang, P. (2014). Identification of microRNA in an ovine model of heart failure. Circulation, 130(Suppl. 2), A16470. [Abstract] Conference Contribution - Published proceedings: Abstract
Charles, C. J., Jardine, D. L., Rademaker, M. T., & Richards, A. M. (2014). Systemic angiotensin II does not increase cardiac sympathetic nerve activity in conscious sheep. Endocrine Reviews, 35(3, Suppl.), MON-0865. Retrieved from http://press.endocrine.org/series/endo-meetings Conference Contribution - Published proceedings: Abstract
Charles, C. (2014, November). Snaring, wiring and pacing hearts: Sheep models unravelling cardiovascular disease. Verbal presentation at the HeartOtago First Australasian Symposium: Bench to Bedside and Back: New Advances in Cardiovascular Research, Dunedin, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Rademaker, M. T., Charles, C. J., & Richards, M. (2014). Sheep for the study of the urocortins and other hormones. Cardiovascular Endocrinology, 3(1), 39-43. doi: 10.1097/XCE.0000000000000024 Journal - Research Article
Charles, C. J., Jardine, D. L., Rademaker, M. T., & Richards, A. M. (2014). Low-dose B-type natriuretic peptide raises cardiac sympathetic nerve activity in sheep. American Journal of Physiology: Regulatory, Integrative & Comparative Physiology, 307(2), R206-R211. doi: 10.1152/ajpregu.00404.2013 Journal - Research Article
Richards, M., Troughton, R., Espiner, E., Cameron, V., Ellmers, L., Pilbrow, A., Charles, C., Rademaker, M., Pemberton, C., & Yandle, T. (2013). Christchurch Heart Institute. In P. Joyce, G. Nicholls, K. Thomas & T. Wilkinson (Eds.), The Christchurch experience: 40 years of research and teaching. (pp. 68-74). Christchurch, New Zealand: University of Otago. Chapter in Book - Other
Trainor, K. E., Roberts, A., Weeks, B., Jackson, N., Troughton, R. W., Charles, C. J., Rademaker, M. T., Melton, I. C., Crozier, I. G., … Clubb, Jr, F. J. (2013). Comparative pathology of an implantable left atrial pressure sensor. ASAIO Journal, 59(5), 486-492. doi: 10.1097/MAT.0b013e31829bdffd Journal - Research Article
Siriwardena, M., Charles, C. J., Byers, M., Richards, A. M., & Pemberton, C. J. (2013). BNP signal peptide is protective in ischaemia reperfusion injury. Heart, Lung & Circulation, 22(7), (pp. 578-579). doi: 10.1016/j.hlc.2013.04.074 Conference Contribution - Published proceedings: Abstract
Rademaker, M. T., Charles, C. J., Nicholls, M. G., & Richards, A. M. (2013). Interactions of enhanced urocortin 2 and mineralocorticoid receptor antagonism in experimental heart failure. Circulation: Heart Failure, 6(4), 825-832. doi: 10.1161/circheartfailure.112.000205 Journal - Research Article
Roberts, A., Trainor, K. E., Weeks, B., Jackson, N., Troughton, R. W., Charles, C. J., Rademaker, M. T., Melton, I. C., Crozier, I. G., … Clubb, Jr, F. J. (2013). Integrated microscopy techniques for comprehensive pathology evaluation of an implantable left atrial pressure sensor. Journal of Histotechnology, 36(1), 17-27. doi: 10.1179/2046023613Y.0000000021 Journal - Research Article
Charles, C. J., Rademaker, M. T., Jardine, D. L., Chan, W., Ellmers, L. J., Troughton, R. W., & Richards, A. M. (2012). Urocortin 2: Neurohumoral mechanisms in heart disease. Heart, Lung & Circulation, 21(12), (pp. 863). doi: 10.1016/j.hlc.2012.08.033 Conference Contribution - Published proceedings: Abstract
Charles, C. J., Jardine, D. L., & Richards, A. M. (2012). B-type natriuretic peptide at non hypotensive doses raises cardiac sympathetic nerve activity in sheep. Proceedings of the Medical Sciences Congress (MedSci). (pp. 29). Retrieved from http://www.medscinz.co.nz/QRW2012%20MedSci%20Abstracts.pdf Conference Contribution - Published proceedings: Abstract
Rademaker, M. T., Yandle, T. G., Ellmers, L. J., Charles, C. J., Nicholls, M. G., & Richards, A. M. (2012). Hemodynamic, hormonal, and renal effects of (pro)renin receptor blockade in experimental heart failure. Circulation: Heart Failure, 5, 645-652. doi: 10.1161/circheartfailure.112.967059 Journal - Research Article
Chan, W., Jardine, D., Butler, J., Charles, C., Troughton, R., & Richards, M. (2012). Urocortin-2 increases muscle sympathetic nerve activity (MSNA) in healthy man. Heart, Lung & Circulation, 21(8), (pp. 482). doi: 10.1016/j.hlc.2012.03.022 Conference Contribution - Published proceedings: Abstract
Rademaker, M. T., Charles, C. J., Nicholls, M. G., & Richards, A. M. (2012). Haemodynamic, endocrine and renal actions of adrenomedullin 5 in an ovine model of heart failure. Clinical Science, 122(9), 429-437. doi: 10.1042/cs20110483 Journal - Research Article
Patel, K., Rademaker, M. T., Kirkpatrick, C. M. J., Charles, C. J., Fisher, S., Yandle, T. G., & Richards, A. M. (2012). Comparative pharmacokinetics and pharmacodynamics of urocortins 1, 2 and 3 in healthy sheep. British Journal of Pharmacology, 166(6), 1916-1925. doi: 10.1111/j.1476-5381.2012.01904.x Journal - Research Article
Charles, C. J., Espiner, E. A., Nicholls, M. G., Pemberton, C. J., Troughton, R. W., Yandle, T. G., & Richards, A. M. (2011, September). Cardiac biomarkers: Clinical utility for diagnosis, prognosis and guiding treatment of cardiovascular disease. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Ellmers, L. J., Richards, M. A., Charles, C. J., & Rademaker, M. T. (2011). (Pro)renin receptor blockade improves cardiac function and reduces ventricular remodeling following myocardial infarction in mice. European Heart Journal, 32(Suppl. 1), (pp. 693). doi: 10.1093/eurheartj/ehr324 Conference Contribution - Published proceedings: Abstract
Charles, C., Rademaker, M., Melton, I., Siou, J., Shah, R., Qu, F., … Troughton, R. (2011). New discoveries regarding the limitations of impedance monitoring for heart failure management. Journal of Cardiac Failure, 17(8, Suppl. 1), (pp. S99). doi: 10.1016/j.cardfail.2011.06.332 Conference Contribution - Published proceedings: Abstract
Rademaker, M. T., Charles, C. J., Nicholls, G., & Richards, M. (2011). Urocortin 2 sustains haemodynamic and renal function during introduction of beta-blockade in experimental heart failure. Journal of Hypertension, 29, 1787-1795. doi: 10.1097/HJH.0b013e3283493776 Journal - Research Article
Charles, C. J., Jardine, D. L., Rademaker, M. T., & Richards, M. (2011). Urocortin 3 inhibits cardiac sympathetic nerve activity in conscious sheep. Journal of Cardiovascular Pharmacology, 58(4), 418-423. doi: 10.1097/FJC.0b013e31822707a4 Journal - Research Article
Charles, C. J. (2011). Update on apelin peptides as putative targets for cardiovascular drug discovery. Expert Opinion on Drug Discovery, 6(6), 633-644. doi: 10.1517/17460441.2011.571251 Journal - Research Article
Rademaker, M. T., Charles, C. J., Ellmers, L. J., Lewis, L. K., Nicholls, M. G., & Richards, A. M. (2011). Prolonged urocortin 2 administration in experimental heart failure: Sustained hemodynamic, endocrine, and renal effects. Hypertension, 57, 1136-1144. doi: 10.1161/HYPERTENSIONAHA.111.173203 Journal - Research Article
Charles, C. J., Rademaker, M. T., & Richards, A. M. (2011). Hemodynamic, hormonal, and renal actions of adrenomedullin-5 in normal conscious sheep. Journal of Cardiovascular Pharmacology, 58(1), 25-31. doi: 10.1097/FJC.0b013e31821a9473 Journal - Research Article
Rademaker, M. T., Charles, C. J., Melton, I. C., Richards, A. M., Frampton, C. M., Siou, J., … Troughton, R. W. (2011). Monitoring of heart failure: Comparison of left atrial pressure with intrathoracic impedance and natriuretic peptide measurements in an experimental model of ovine heart failure. Clinical Science, 120(5), 207-217. doi: 10.1042/CS20100388 Journal - Research Article
Rademaker, M., Charles, C., Melton, I., Richards, M., Frampton, C., Siou, J., … Troughton, R. (2010, November-December). Monitoring of heart failure: Comparison of left atrial pressure with intrathoracic impedance and natriuretic peptide measurements in an experimental model of ovine heart failure. Verbal presentation at the Medical Sciences Congress: A New Decade of Discovery (MedSciNZ), Queenstown, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Bhandari, S., Charles, C. J., Miller, A. P., Scott-Thomas, A., Syhre, M., & Chambers, S. T. (2010, September). Cyclophosphamide pulmonary toxicity limiting sheep model of immunosuppression. Poster session presented at the Fourth Annual Division of Health Sciences Research Forum, Dunedin, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)
Charles, C. J., Rademaker, M. T., Nicholls, M. G., & Richards, A. M. (2010). Adrenomedullin 2 attenuates the pressor but not adrenal responses to angiotensin II in conscious sheep. Peptides, 31, 878-882. doi: 10.1016/j.peptides.2010.02.010 Journal - Research Article
Charles, C. J., Jardine, D. L., Rademaker, M. T., & Richards, A. M. (2010). Urocortin 2 induces potent long-lasting inhibition of cardiac sympathetic drive despite baroreflex activation in conscious sheep. Journal of Endocrinology, 204, 181-189. doi: 10.1677/JOE-08-0505 Journal - Research Article
Charles, C. J., Jardine, D. L., Rademaker, M. T., & Richards, A. M. (2009). Sympathoinhibitory actions of the urocortin peptides suggest therapeutic potential in acute cardiac injury. Clinical Autonomic Research. 19(5), (pp. 284). doi: 10.1007/s10286-009-0030-5 Conference Contribution - Published proceedings: Abstract
Prickett, T. C. R., Charles, C. J., Yandle, T. G., Richards, A. M., & Espiner, E. A. (2009). Skeletal contributions to plasma CNP forms: Evidence from regional sampling in growing lambs. Peptides, 30(12), 2343-2347. doi: 10.1016/j.peptides.2009.07.023 Journal - Research Article
Rademaker, M. T., Charles, C. J., Nicholls, M. G., & Richards, A. M. (2009). Urocortin 2 inhibits furosemide-induced activation of renin and enhances renal function and diuretic responsiveness in experimental heart failure. Circulation: Heart Failure, 2(6), 532-540. doi: 10.1161/CIRCHEARTFAILURE.109.861336 Journal - Research Article
Prickett, T. C., Charles, C. J., Yandle, T. G., Richards, A. M., & Espiner, E. A. (2009). Regional sampling and effects of glucocorticoids: Differential responses in A, B and C-type natriuretic peptides in growing lambs. Proceedings of the Endocrine Society's 91st Annual Meeting. Retrieved from http://www.abstracts2view.com/endo/ Conference Contribution - Published proceedings: Abstract
Charles, C. J., Jardine, D. L., Rademaker, M. T., & Richards, A. M. (2008). Sympathoinhibitory actions of the urocortins suggest therapeutic potential in acute cardiac injury. Proceedings of the 2nd Cardiovascular Control Conference. CCC. Retrieved from http://cccindia08.florey.edu.au/India08%20Abstracts.pdf Conference Contribution - Published proceedings: Abstract
Charles, C. (2008, October). ″Sympathetic scientist gets hormonal about hearts″: Hearts, hormones and cardiac sympathetic drive in animal models of normal health and cardiac injury. Verbal presentation at the New Zealand-Singapore Heart Failure Research Symposium, Christchurch, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Charles, C. J., Rademaker, M. T., Nicholls, M. G., & Richards, A. M. (2008, November). Adrenomedullin 2 attenuates the pressor but not adrenal responses to angiotensin II in conscious sheep. Verbal presentation at the Medical Sciences Congress, Queenstown, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Rademaker, M. T., Charles, C. J., Nicholls, M. G., & Richards, A. M. (2008). Hemodynamic, hormonal and renal actions of adrenomedullin 2 in experimental heart failure. Arquivos Brasileiros de Endocrinologia & Metabologia. 52(Suppl. 6 (Parte II)), (pp. S807-S808). [Abstract] Conference Contribution - Published proceedings: Abstract
Charles, C. J. (2008). The apelin peptides as putative targets in cardiovascular drug discovery and development. Expert Opinion on Drug Discovery, 3(1), 51-64. doi: 10.1517/17460441.3.1.51 Journal - Research Article
Rademaker, M. T., Charles, C. J., Nicholls, M. G., & Richards, A. M. (2008). Hemodynamic, hormonal, and renal actions of adrenomedullin 2 in experimental heart failure. Circulation: Heart Failure, 1, 134-142. doi: 10.1161/circheartfailure.107.755504 Journal - Research Article
Charles, C., Jardine, D., Nicholls, G., Rademaker, M., & Richards, M. (2008). Urocortin 2 induces potent long-lasting inhibition of cardiac sympathetic drive despite baroreflex activation in conscious sheep. Heart, Lung & Circulation, 17(Suppl. 1), (pp. S1). doi: 10.1016/j.hlc.2007.11.002 Conference Contribution - Published proceedings: Abstract
Rademaker, M. T., Charles, C. J., Nicholls, M. G., & Richards, A. M. (2008). Urocortin 2 combined with angiotensin-converting enzyme inhibition in experimental heart failure. Clinical Science, 114(10), 635-642. doi: 10.1042/CS20070364 Journal - Research Article
Charles, C. J., Jardine, D. L., Nicholls, M. G., Rademaker, M. T., & Richards, A. M. (2008). Urocortin 1 exhibits potent inhibition of cardiac sympathetic nerve activity in conscious sheep. Journal of Hypertension, 26(1), 53-60. Journal - Research Article
Charles, C. J., Katafuchi, T., Yandle, T. G., & Minamino, N. (2008). Identification and biological activity of ovine and caprine calcitonin receptor-stimulating peptides 1 and 2. Journal of Endocrinology, 198(2), 429-437. doi: 10.1677/JOE-08-0106 Journal - Research Article
Charles, C. J., Jardine, D. L., Nicholls, M. G., Rademaker, M. T., & Richards, A. M. (2007). Urocortin 1 inhibits cardiac sympathetic nerve activity in normal conscious sheep. Endocrine Journal. 54(Suppl.), (pp. 194). [Abstract] Conference Contribution - Published proceedings: Abstract
Khoury, D. S., Naware, M., . . ., Rademaker, M., Charles, C., Troughton, R., & Panescu, D. (2007). Physiologic monitoring of congestive heart failure by multiple impedance vectors. Heart Rhythm. 4(5 (Suppl. S)), (pp. S393). [Abstract] Conference Contribution - Published proceedings: Abstract
Charles, C. J., Jardine, D. L., Rademaker, M. T., & Richards, A. M. (2007). Urocortin 1 exhibits potent inhibition of cardiac sympathetic nerve activity in ambulent sheep. Journal of Molecular & Cellular Cardiology, 42(6, Suppl. 1), (pp. S35). [Abstract] Conference Contribution - Published proceedings: Abstract
Jardine, D. L., & Charles, C. J. (2007). The immediate effects of IV beta-blockade on cardiac sympathetic nerve activity in the conscious sheep model. Clinical Autonomic Research. 17, (pp. 277). [Abstract] Conference Contribution - Published proceedings: Abstract
Charles, C. J., Jardine, D. L., & Richards, A. M. (2007). Cardiac sympathetic nerve activity and ventricular fibrillation during acute myocardial infarction in ambulent sheep. Journal of Molecular & Cellular Cardiology, 42(6, Suppl. 1), (pp. S8). [Abstract] Conference Contribution - Published proceedings: Abstract
Charles, C. J., Jardine, D. L., Nicholls, M. G., Rademaker, M. T., & Richards, A. M. (2007). Urocortin 1 exhibits potent inhibition of cardiac sympathetic nerve activity in ambulant sheep. European Journal of Heart Failure Supplements, 6(Suppl. 1), (pp. 145). doi: 10.1016/S1567-4215(07)60405-6 Conference Contribution - Published proceedings: Abstract
Charles, C. J., Rademaker, M. T., Yandle, T. G., & Richards, A. M. (2007). Arterio-venous trans-organ sampling in normal and heart failure sheep: Determining the source of circulating hormones. Endocrine Journal. 54(Suppl.), (pp. 80). [Abstract] Conference Contribution - Published proceedings: Abstract
Nabutovsky, Y., Naware, M., Siou, J., Pillai, A., Illindala, U., Holmstrom, N., … Rademaker, M., Charles, C., Troughton, R., & Panescu, D. (2007). Pilot investigation of cardiogenic impedance during heart failure induction using a new prototype ICD. Journal of Cardiac Failure, 13(6, Suppl. 2), (pp. S123). doi: 10.1016/j.cardfail.2007.06.478 Conference Contribution - Published proceedings: Abstract
Khoury, D., Naware, M., Siou, J., Gutfinger, D., Eigler, N., Ohlander, M., … Rademaker, M., Charles, C., Troughton, R., & Panescu, D. (2007). Heart failure trending by multiple-vector impedance. Journal of Cardiac Failure, 13(6, Suppl. 2), (pp. S129). doi: 10.1016/j.cardfail.2007.06.498 Conference Contribution - Published proceedings: Abstract
Charles, C. (2007, August). Adrenomedullins. Verbal presentation at the Cardiac Society of Australia and New Zealand 55th Annual Scientific Meeting, Christchurch, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Charles, C. J., Jardine, D. L., Nicholls, M. G., Rademaker, M. T., & Richards, A. M. (2007, November). Urocortin 2 induces potent long-lasting inhibition of cardiac sympathetic drive despite baroreflex activation in conscious sheep. Verbal presentation at the Medical Sciences Congress, Queenstown, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Charles, C. J., Jardine, D. L., & Richards, A. M. (2007). Cardiac sympathetic nerve activity and ventricular fibrillation during acute myocardial infarction in a conscious sheep model. European Journal of Heart Failure Supplements, 6(Suppl. 1), (pp. 154). doi: 10.1016/S1567-4215(07)60431-7 Conference Contribution - Published proceedings: Abstract
Charles, C. J., Jardine, D. L., Rademaker, M. T., & Richards, A. M. (2007, July). Urocortin 1 exhibits potent inhibition of cardiac sympathetic nerve activity in conscious sheep. Poster session presented at the FASEB Summer Research Conferences, Sydney, Australia. Conference Contribution - Poster Presentation (not in published proceedings)
Charles, C. J. (2007). Putative role for apelin in pressure/volume homeostasis and cardiovascular disease. Cardiovascular & Hematological Agents in Medicinal Chemistry, 5, 1-10. Journal - Research Article
Rademaker, M. T., Charles, C. J., & Richards, A. M. (2007). Urocortin 1 administration from onset of rapid left ventricular pacing represses progression to overt heart failure. American Journal of Physiology: Heart & Circulatory Physiology, 293, H1536-H1544. doi: 10.1152/ajpheart.00377.2007 Journal - Research Article
Jardine, D. L., Charles, C. J., Frampton, C. M., & Richards, A. M. (2007). Cardiac sympathetic nerve activity and ventricular fibrillation during acute myocardial infarction in a conscious sheep model. American Journal of Physiology: Heart & Circulatory Physiology, 293, H433-H439. doi: 10.1152/ajpheart.01262.2006 Journal - Research Article
Charles, C. J., Rademaker, M. T., & Richards, A. M. (2007). Urocortin 1 modulates the neurohumoral response to acute nitroprusside-induced hypotension in sheep. Clinical Science, 112, 485-491. Journal - Research Article
Chambers, S. T., Pithie, A., Gallagher, K., Liu, T., Charles, C. J., & Seaward, L. (2007). Treatment of Staphylococcus epidermidis central vascular catheter infection with 70% ethanol locks: Efficacy in a sheep model. Journal of Antimicrobial Chemotherapy, 59, 779-782. Journal - Research Article
Charles, C. J., Jardine, D. L., Nicholls, M. G., & Richards, A. M. (2006). Adrenomedullin increases cardiac sympathetic nerve activity in normal conscious sheep. New Zealand Medical Journal, 119(1231). Retrieved from http://journal.nzma.org.nz/journal/119-1231/1922/content.pdf Conference Contribution - Published proceedings: Abstract
Rademaker, M. T., Cameron, V. A., Charles, C. J., & Richards, A. M. (2006). Urocortin 3: Haemodynamic, hormonal, and renal effects in expermental heart failure. European Heart Journal, 27(17), 2088-2098. Journal - Research Article
Rademaker, M. T., Cameron, V. A., Charles, C. J., & Richards, A. M. (2006). [Response to the letter regarding Article by Rademaker et al, ″Integrated hemodynamic, hormonal, and renal actions of Urocortin 2 in normal and paced sheep: Beneficial effects in heart failure″]. Circulation, 113. Retrieved from http://www.circ.ahajournals.org/cgi/content/full/113/15/e710 Journal - Research Other
Charles, C. J., Rademaker, M. T., & Richards, A. M. (2006). Hemodynamic, hormonal, and renal actions of adrenomedullin-2 in normal conscious sheep. Endocrinology, 147(4), 1871-1877. Journal - Research Article
Charles, C. J., Rademaker, M. T., & Richards, A. M. (2006). Apelin-13 induces a biphasic haemodynamic response and hormonal activation in normal conscious sheep. Journal of Endocrinology, 189(3), 701-710. Journal - Research Article
Charles, C. J., Rademaker, M. T., Richards, A. M., & Yandle, T. G. (2006). Plasma urocortin 1 in sheep: Regional sampling and effects of experimental heart failure. Peptides, 27, 1801-1805. Journal - Research Article
Charles, C. J., Prickett, T. C. R., Espiner, E. A., Rademaker, M. T., Richards, A. M., & Yandle, T. G. (2006). Regional sampling and the effects of experimental heart failure in sheep: Differential responses in A, B and C-type natriuretic peptides. Peptides, 27(1), 62-68. doi: 10.1016/j.peptides.2005.06.019 Journal - Research Article
Charles, C. J., Jardine, D. L., Nicholls, M. G., & Richards, A. M. (2005). Adrenomedullin increases cardiac sympathetic nerve activity in normal conscious sheep. Journal of Endocrinology, 187, 275-281. Journal - Research Article
Charles, C. J. (2005, December). Adrenomedullins: Integrative physiological studies indicate a role in pressure-volume homeostasis and in heart disease [Invited]. Verbal presentation at the 2nd Medical Sciences Congress: Genome to therapy, Queenstown, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Jardine, D. L., Charles, C. J., & Nicholls, M. G. (2005, October). Cardiac sympathetic nerve activity ″at the death″. Verbal presentation at the 16th International Symposium on the Autonomic Nervous System, Los Cabos, Mexico. Conference Contribution - Verbal presentation and other Conference outputs
Charles, C. J., Jardine, D. L., Nicholls, M. G., & Richards, A. M. (2005, October). Adrenomedullin increases cardiac sympathetic nerve activity in normal conscious sheep. Verbal presentation at the 16th International Symposium on the Autonomic Nervous System, Los Cabos, Mexico. Conference Contribution - Verbal presentation and other Conference outputs
Rademaker, M. T., Charles, C. J., Cameron, V. A., & Richards, A. M. (2005). Urocortin 2 has beneficial hemodynamic, endocrine and renal effects in experimental heart failure. The Journal of Heart Disease. 4(1), (pp. 129). [Abstract] Conference Contribution - Published proceedings: Abstract
Charles, C. J., Rademaker, M. T., Richards, A. M., & Yandle, T. G. (2005). Urotensin II: Evidence for cardiac, hepatic and renal production. Peptides, 26, 2211-2214. doi: 10.1016/j.peptides.2005.03.043 Journal - Research Article
Rademaker, M. T., Charles, C. J., Espiner, E. A., Frampton, C. M., Lainchbury, J. G., & Richards, A. M. (2005). Four-day urocortin-I administration has sustained beneficial haemodynamic, hormonal, and renal effects in experimental heart failure. European Heart Journal, 26, 2055-2062. doi: 10.1093/eurheartj/ehi351 Journal - Research Article
Rademaker, M. T., Charles, C. J., Espiner, E. A., Frampton, C. M., Lainchbury, J. G., & Richards, A. M. (2005). Endogenous urocortins reduce vascular tone and renin-aldosterone / endothelin activity in experimental heart failure. European Heart Journal, 26(19), 2046-2054. doi: 10.1093/eurheartj/ehi227 Journal - Research Article
Rademaker, M. T., Cameron, V. A., Charles, C. J., & Richards, A. M. (2005). Integrated hemodynamic, hormonal, and renal actions of urocortin 2 in normal and paced sheep: Beneficial effects in heart failure. Circulation, 112, 3624-3632. doi: 10.1161/CIRCULATIONAHA.105.561308 Journal - Research Article
Charles, C. J., Rademaker, M. T., Nicholls, M. G., & Richards, A. M. (2005). Adrenomedullin in heart failure: Potential therapeutic implications. Future Cardiology, 1(2), 235-243. Journal - Research Article
Jardine, D. L., Charles, C. J., Ashton, R. K., Bennett, S. I., Whitehead, M., Frampton, C. M., & Nicholls, M. G. (2005). Increased cardiac sympathetic nerve activity following acute myocardial infarction in a sheep model. Journal of Physiology, 565(1), 325-333. doi: 10.1113/jphysiol.2004.082198 Journal - Research Article
Charles, C., Rademaker, M., Richards, M., & Nicholls, G. (2004). Potential for targeting adrenomedullin mechanisms in heart failure. Journal of Molecular & Cellular Cardiology, 37(S37E), (pp. 345). doi: 10.1016/j.yjmcc.2004.05.003 Conference Contribution - Published proceedings: Abstract
Charles, C. J., Rademaker, M. T., & Richards, A. M. (2004). Urocortins: Putative role in cardiovascular disease. Current Medicinal Chemistry: Cardiovascular & Hematological Agents, 2, 43-47. Journal - Research Article
Rademaker, M., Charles, C., Espiner, E., Lainchbury, J., Nicholls, G., & Richards, M. (2004). Chronic urocortin administration in experimental heart failure. Proceedings of the 12th International Congress of Endocrinology. (pp. 174-175). [Abstract] Conference Contribution - Published proceedings: Abstract
Richards, A. M., & Charles, C. (2004). Urotensin II in the cardiovascular system. Peptides, 25(10), 1795-1802. doi: 10.1016/j.peptides.2004.04.017 Journal - Research Article
Rademaker, M. T., Charles, C. J., Espiner, E. A., Frampton, C. M., Nicholls, M. G., & Richards, A. M. (2004). Combined inhibition of angiotensin II and endothelin suppresses the brain natriuretic peptide response to developing heart failure. Clinical Science, 106, 569-576. Journal - Research Article
Jardine, D., Charles, C. J., Forrester, M. D., Whitehead, M., & Nicholls, M. G. (2003). A neural mechanism for sudden death after myocardial infarction. Clinical Autonomic Research, 13, 339-341. Journal - Research Article
Rademaker, M. T., Cameron, V. A., Charles, C. J., Lainchbury, J. G., Nicholls, M. G., & Richards, A. M. (2003). Adrenomedullin and heart failure. Regulatory Peptides, 112(1-3), 51-60. Journal - Research Article
Nicholls, M. G., Charles, C. J., Lainchbury, J. G., Lewis, L. K., Rademaker, M. T., Richards, A. M., & Yandle, T. G. (2003). Adrenomedullin in heart failure. Hypertension Research, 26(Suppl.), S135-S140. doi: 10.1291/hypres.26.S135 Journal - Research Article
Charles, C. J., Elliott, J. M., Nicholls, M. G., Rademaker, M. T., & Richards, A. M. (2003). Natriuretic peptides maintain sodium homoeostasis during chronic volume loading post-myocardial infarction in sheep. Clinical Science, 104(4), 429-436. Journal - Research Article
Charles, C. J., Lainchbury, J. G., Nicholls, M. G., Rademaker, M. T., Richards, A. M., & Troughton, R. W. (2003). Adrenomedullin and the renin-angiotensin-aldosterone system. Regulatory Peptides, 112(1-3), 41-49. Journal - Research Article
Rademaker, M. T., Charles, C. J., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (2002, November). Chronic adrenomedullin administration in experimental heart failure. Verbal presentation at the 3rd International Symposium on Adrenomedullin and PAMP, Osaka, Japan. Conference Contribution - Verbal presentation and other Conference outputs
Jardine, D. L., Charles, C. J., Brennan, R. K., Frampton, C. M., & Nicholls, M. G. (2002). Cardiac sympathetic nerve activity during myocardial infarction. Verbal presentation at the 13th International Symposium on the Autonomic Nervous System, Hilton Head Island, USA. Conference Contribution - Verbal presentation and other Conference outputs
Charles, C. J., Jardine, D. L., & Nicholls, M. G. (2002). Cardiac sympathetic nerve activity in conscious sheep: Effect of myocardial infarction. Verbal presentation at the Xth World Congress of Cardiology, Sydney, Australia. Conference Contribution - Verbal presentation and other Conference outputs
Rademaker, M. T., Charles, C. J., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (2002). hronic adrenomedullin administration in experimental heart failure. Verbal presentation at the 3rd International Symposium on Adrenomedullin and PAMP, Osaka, Japan. Conference Contribution - Verbal presentation and other Conference outputs
Jardine, D., Charles, C. J., Melton, I., May, C. N., Forrester, M. D., Frampton, C. M., … Ikram, H. (2002). Continual recordings of cardiac sympathetic nerve activity in conscious sheep. American Journal of Physiology: Heart & Circulatory Physiology, 282, H93-H99. Journal - Research Article
Rademaker, M. T., Charles, C. J., Espiner, E. A., Fisher, S., Frampton, C. M., Kirkpatrick, C., Lainchbury, J. G., Nicholls, M. G., & Richards, A. M. (2002). Urocortin has beneficial hemodynamic, endocrine and renal effects in experimental heart failure. Abstracts presented at the Joint Meeting of the 19th Scientific Meeting of the International Society of Hypertension and the 12th European Meeting on Hypertension. 20(supplement), (pp. P1300). Prague, Czech Republic: Lippincott Williams & Wilkins Healthcare. [Abstract] Conference Contribution - Published proceedings: Abstract
Rademaker, M. T., Charles, C. J., Espiner, E. A., Fisher, S., Frampton, C. M., Kirkpatrick, C. M. J., Lainchbury, J. G., Nicholls, M. G., Richards, A. M., & Vale, W. W. (2002). Beneficial hemodynamic, endocrine, and renal effects of urocortin in experimental heart failure: Comparison with normal sheep. JACC, 40(8), 1495-1505. Journal - Research Article
Rademaker, M. T., Charles, C. J., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (2002). Long-Term adrenomedullin administration in experimental heart failure. Hypertension, 40(5), 667-672. Journal - Research Article
Rademaker, M. T., Charles, C. J., Cooper, G. J. S., Coy, D. H., Espiner, E. A., Lewis, L. K., Nicholls, M. G., & Richards, A. M. (2002). Combined angiotensin-converting enzyme inhibition and adrenomedullin in an ovine model of heart failure. Clinical Science, 102(6), 653-660. Journal - Research Article
Rademaker, M. T., Charles, C. J., Cooper, G. J. S., Coy, D. H., Espiner, E. A., Lewis, L. K., Nicholls, M. G., & Richards, A. M. (2002). Combined endopeptidase inhibition and adrenomedullin in sheep with experimental heart failure. Hypertension, 39(1), 93-98. Journal - Research Article
Charles, C. J., Nicholls, M. G., Rademaker, M. T., & Richards, A. M. (2002). Adrenomedullin modulates the neurohumoral response to acute volume loading in normal conscious sheep. Journal of Endocrinology, 173(1), 123-129. Journal - Research Article
Rademaker, M. T., Charles, C. J., Lewis, L. K., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (2001). Combined adrenomedullin adminstration and angiotensin-converting enzyme inhibition in experimental heart failure. Verbal presentation at the 34th International Congress of Physiological Sciences, Christchurch. Conference Contribution - Verbal presentation and other Conference outputs
Jardine, D., Charles, C. J., Forrester, M. D., Whitehead, M., & Ikram, H. (2001). The neural mechanism for sudden cardiac death. Verbal presentation at the The Sympathetic Nervous System in Disease: Official Satellite to IUPS, Christchurch. Conference Contribution - Verbal presentation and other Conference outputs
Charles, C. J., Nicholls, M. G., Rademaker, M. T., & Richards, A. M. (2001). Andrenomedullin augments the neurohumoral response to hemorrhage in non-pregnant but not pregnant sheep. Verbal presentation at the 34th International Congress of Physiological Sciences, Christchurch. Conference Contribution - Verbal presentation and other Conference outputs
Charles, C. J., Jardine, D., Forrester, M. D., & Nicholls, M. G. (2001). Continuous recording of cardiac sympathetic nerve activity in conscious sheep. Verbal presentation at the International Society for Heart Research Australasian Meeting: Models in Cardiovascular Research, Brisbane. Conference Contribution - Verbal presentation and other Conference outputs
Espiner, E. A., Cameron, A. V., Charles, C., Nicholls, M. G., Rademaker, M. T., Richards, A. M., & Yandle, T. (2001). The endocrine heart. Proceedings of the New Zealand Endocrine Society Annual Meeting. (pp. A43). [Abstract] Conference Contribution - Published proceedings: Abstract
Rademaker, M. T., Charles, C. J., Espiner, E. A., Lewis, L. K., Nicholls, M. G., & Richards, A. M. (2001, August). Combined adrenomedullin administration and angiotensin-converting enzyme inhibition in experimental heart failure. Verbal presentation at the 34th International Congress of Physiological Sciences, Christchurch, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Charles, C. J., Nicholls, M. G., Rademaker, M. T., & Richards, A. M. (2001, August). Adrenomedullin augments the neurohumoral response to hemorrhage in non-pregnant but not pregnant sheep. Verbal presentation at the 34th International Congress of Physiological Sciences, Christchurch, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Aitken, G. D., Cameron, V. A., Rademaker, M. T., Charles, C. J., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (2001). Increased atrial but not ventricular ANP and BNP expression in a paced model of heart failure. Journal of Biochemistry, Molecular Biology & Biophysics, 5, 199-207. Journal - Research Article
Charles, C. J., Nicholls, M. G., Rademaker, M. T., & Richards, A. M. (2001). Comparative actions of adrenomedullin and nitroprusside: Interactions with ANG II and norepinephrine. American Journal of Physiology: Regulatory, Integrative & Comparative Physiology, 281(6), R1887-R1894. Journal - Research Article
Charles, C. J., Rademaker, M. T., Richards, A. M., & Nicholls, M. G. (2001). Adrenomedullin augments the neurohumoral response to haemorrhage in non-pregnant but not in pregnant sheep. Journal of Endocrinology, 171(2), 363-371. Journal - Research Article
Charles, C. J., Rademaker, M. T., Richards, A. M., Cooper, G. J. S., Coy, D. H., & Nicholls, M. G. (2000). Adrenomedullin attenuates pressor response to angiotensin II in concious sheep. 11th International Congress of Endocrinology. 36. [Abstract] Conference Contribution - Published proceedings: Abstract
Rademaker, M. T., Charles, C. J., Cooper, G. J. S., Coy, D. H., Espiner, E. A., Lewis, L. K., Nicholls, M. G., Pemberton, C. J., & Richards, A. M. (2000, October). Combined adrenomedullin administration and neutral endopeptidase inhibitor in heart failure. Verbal presentation at the 4th Annual Meeting of the Society for Cardiovascular Endocrinology and Metabolism, Australia. Conference Contribution - Verbal presentation and other Conference outputs
Charles, C. J., Nicholls, M. G., Rademaker, M. T., & Richards, A. M. (2000). Adrenomedullin augments the neurohumoral response to hemorrhage in normal conscious sheep. Verbal presentation at the 4th Annual Meeting of the Society for Cardiovascular Endocrinology and Metabolism, Queensland. Conference Contribution - Verbal presentation and other Conference outputs
Troughton, R. W., McGregor, D. O., Charles, C. J., Lewis, L. K., Yandle, T., Richards, A. M., & Nicholls, M. G. (2000). Biological effects of adrenomedullin infusion in healthy volunteers, essential hypertension and chronic renal failure. Verbal presentation at the 2nd International Symposium on Adrenomedullin and PAMP, Japan. Conference Contribution - Verbal presentation and other Conference outputs
Rademaker, M. T., Charles, C. J., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (2000, October/November). Combined adrenomedullin administration and neutral endopeptidase inhibition in heart failure. Verbal presentation at the 11 th International Congress of Endocrinology, Sydney. Conference Contribution - Verbal presentation and other Conference outputs
Charles, C. J., Rademaker, M. T., Richards, A. M., Cooper, G. J. S., Coy, D. H., & Nicholls, M. G. (2000). Adrenomedullin attenuates pressor response to angiotensin II in concious sheep. Journal of Cardiovascular Pharmacology, 36, 526-532. Journal - Research Article
Smith, M. W., Espiner, E. A., Yandle, T. G., Charles, C. J., & Richards, A. M. (2000). Delayed metabolism of human brain natriuretic peptide reflects resistance to neutral endopeptidase. Journal of Endocrinology, 167(2), 239-246. Journal - Research Article
Charles, C. J., Rademaker, M. T., & Nicholls, M. G. (2000). Adrenomedullin augments the neurohumoral response to hemorrhage in normal conscious sheep. 18th Scientific Meeting of the International Society of Hypertension. (pp. 3). Chicago. [Abstract] Conference Contribution - Published proceedings: Abstract
Charles, C. J., Rademaker, M. T., Richards, A. M., & Nicholls, M. G. (2000). Interactions of adrenomedullin with incremental infusions of angiotensin II and norepinephrine in conscious sheep; comparison with nitroprusside. Proceedings of 11th International Congress of Endocrinology. (pp. 985). Sydney. [Abstract] Conference Contribution - Published proceedings: Abstract
Charles, C. J., Elliott, J. M., Nicholls, M. G., Rademaker, M. T., & Richards, A. M. (2000). Myocardial infarction with and without reperfusion in sheep: Early cardiac and neurohumoral changes. Clinical Science, 98, 703-711. Journal - Research Article
Rademaker, M. T., Cameron, V. A., Charles, C. J., Espiner, E. A., Nicholls, M. G., Pemberton, C. J., & Richards, A. M. (2000). Neurohormones in an ovine model of compensated post-infarction left ventricular dysfunction. American Journal of Physiology: Heart & Circulatory Physiology, 278, H731-H740. Journal - Research Article
Charles, C. J., Elliott, J. M., Nicholls, M. G., Rademaker, M. T., & Richards, A. M. (1999). Myocardial infarction with and without reperfusion in sheep: Cardiac, neurohumoral and hemodynamic effects. Verbal presentation at the 1st International Congress on Heart Disease, Washington DC, USA. Conference Contribution - Verbal presentation and other Conference outputs
Rademaker, M. T., Troughton, R. W., Charles, C. J., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (1999, August). Acute and chronic administration of Omapatrilat in an ovine model of mild and severe heart failure. Verbal presentation at the 2nd BCCH Symposium, Sydney, Australia. Conference Contribution - Verbal presentation and other Conference outputs
Rademaker, M. T., Troughton, R. W., Charles, C. J., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (1999). Acute and chronic administration of omapatrilat in an ovine model of mild and severe heart failure. Verbal presentation at the 47th Annual Meeting Cardiac Society of Australia and New Zealand, Wellington, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Charles, C. J., Elliott, J. M., Nicholls, M. G., Rademaker, M. T., & Richards, A. M. (1999). Myocardial infarction with and without reperfusion in sheep: Cardiac, neurohumoral and hemodynamic effects. Verbal presentation at the 1st International Congress in Heart Disease, Washington DC, USA. Conference Contribution - Verbal presentation and other Conference outputs
Jardine, D. L., Charles, C. J., Forrester, M. D. E., Bennett, S. I., Melton, I. C., & May, C. N. (1999). Continuous recordings of efferent cardiac sympathetic nerve activity in ambulant sheep. Verbal presentation at the 47th Annual Scientific Meeting of the Cardiac Society of Australia and New Zealand, Wellington, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Charles, C. J., Lainchbury, J. G., Lewis, L. K., Rademaker, M. T., Richards, A. M., Yandle, T. G., & Nicholls, M. G. (1999). The role of adrenomedullin. American Journal of Hypertension, 12(2 Part 1), 166-173. Journal - Research Article
Troughton, R. W., Rademaker, M. T., Charles, C. J., Espiner, E. A., & Nicholls, M. G. (1999). Acute and chronic administration of Omapatrilat in an ovine model in mild and severe heart failure. 72nd Scientific Sessions, American Heart Foundation. (pp. I-300). [Abstract] Conference Contribution - Published proceedings: Abstract
Charles, C. J., Espiner, E. A., Nicholls, M. G., Rademaker, M. T., & Richards, A. M. (1999). Bioactivity of natriuretic peptide coinfusions: no evidence for unique effects of BNP in conscious sheep. Journal of Cardiovascular Pharmacology, 33(2), 229-236. Journal - Research Article
Rademaker, M. T., Charles, C. J., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (1998). Netriuretic peptides and endothelin un an ovine coronary ligation model of mild heart failure. Verbal presentation at the Endo '98, New Orleans. Conference Contribution - Verbal presentation and other Conference outputs
Charles, C. J., Espiner, E. A., Rademaker, M. T., Nicholls, M. G., & Richards, A. M. (1998). Chronic infusions of brain natriuretic peptide in conscious sheep: Bioactivity at low physiological levels. Journal of Hypertension. 16(Suppl. 2), (pp. S143). [Abstract] Conference Contribution - Published proceedings: Abstract
Lainchbury, J. G., Rademaker, M. T., Charles, C. J., Lewis, L. K., Yandle, T. G., Richards, A. M., & Nicholls, M. G. (1998). Adrenomedullin in heart failure. Verbal presentation at the Centre of Excellence International Symposium on Adrenomedullin and PAMP, Osaka, Japan. Conference Contribution - Verbal presentation and other Conference outputs
Rademaker, M. T., Troughton, R. W., Charles, C. J., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (1998, November). Acute and chronic administration of Omapatrilat in an ovine model of mild and severe heart failure. Verbal presentation at the American Heart Association Meeting, Atlanta, USA. Conference Contribution - Verbal presentation and other Conference outputs
Rademaker, M. T., Charles, C. J., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (1998). Natriuretic peptides and endothelin on an ovine coronary artery ligation model of mild heart failure. 80th Annual Endocrine Society Meeting Programme. (A326). [Abstract] Conference Contribution - Published proceedings: Abstract
Rademaker, M. T., Charles, C. J., Espiner, E. A., Nicholls, M. G., Richards, A. M., & Kosoglou, T. (1998). Combined neutral endopeptidase and angiotensin-converting enzyme inhibition in heart failure: role of natriuretic peptides and angiotensin II. Journal of Cardiovascular Pharmacology, 31(1), 116-125. Journal - Research Article
Charles, C. J., Donald, R. A., Ikram, H., Prickett, T., & Richards, A. M. (1998). Arginine vasopressin V1 receptor antagonism in an ovine model of acute myocardial infarction. Journal of Cardiovascular Pharmacology, 32(5), 777-782. Journal - Research Article
Charles, C. J., Espiner, E. A., Nicholls, M. G., Rademaker, M. T., & Richards, A. M. (1998). Chronic infusions of brain natriuretic peptide in conscious sheep: bioactivity at low physiological levels. Clinical Science, 95(6), 701-708. Journal - Research Article
Charles, C. J., Rademaker, M. T., Richards, A. M., Cooper, G. J. S., Coy, D. H., & Nicholls, M. G. (1998). Hemodynamic, hormonal and renal effects of intracerebroventricular adrenomedullin in conscious sheep. Endocrinology, 139(4), 1746-1751. doi: 10.1210/endo.139.4.5862 Journal - Research Article
Pemberton, C. J., Yandle, T. G., Rademaker, M. T., Charles, C. J., Aitken, G. D., & Espiner, E. A. (1998). Amino-terminal proBNP in ovine plasma: evidence for enhanced secretion in response to cardiac overload. American Journal of Physiology: Heart & Circulatory Physiology, 275(4Pt2), H1200-H1208. Journal - Research Article
Lainchbury, J. G., Rademaker, M. T., Charles, C. J., Lewis, L. K., Yandle, T. G., Richards, A. M., & Nicholls, M. G. (1997). Adrenomedullin in heart failure. Verbal presentation at the 1st International Symposium on Adrenomedullin and PAMP, Osaka. Conference Contribution - Verbal presentation and other Conference outputs
Rademaker, M. T., Charles, C. J., Lewis, L. K., Yandle, T. G., Richards, A. M., & Nicholls, M. G. (1997). Beneficial hemodynamic and renal effects of adrenomedullin in an ovine model of heart failure. The Journal of Heart Failure. 4(1), (pp. 74). [Abstract] Conference Contribution - Published proceedings: Abstract
Rademaker, M. T., Charles, C. J., Lewis, L. K., Yandle, T. G., Richards, A. M., & Nicholls, M. G. (1997, June). Beneficial hemodynamic and renal effects of adrenomedullin in an ovine model of heart failure. Verbal presentation at the 8th European Society of Hypertension, Milan. Conference Contribution - Verbal presentation and other Conference outputs
Espiner, E. A., Rademaker, M. T., Charles, C. J., Kosoglou, T., Protter, A., Nicholls, M. G., & Richards, A. M. (1997). Inhibiting natriuretic peptide metabolism has beneficial renal hemodynamic effects, induces natriuresis and inhibits aldosterone in experimental heart failure. Verbal presentation at the 23rd Aldosterone Conference, Minneapolis. Conference Contribution - Verbal presentation and other Conference outputs
Charles, C. J., Rademaker, M. T., Nicholls, M. G., & Richards, A. M. (1997). Biological effects of intracerebroventricular adrenomedullin in normal conscious sheep. Proceedings of the Endocrine Society of Australia. 40, (pp. 16). [Abstract] Conference Contribution - Published proceedings: Abstract
Begg, E. J., Nicholls, M. G., Rademaker, M. T., & Charles, C. J. (1997). Pharmacokinetics of adrenomedullin in a sheep model of heart failure. Proceedings of ASCEPT, 3, 34. Journal - Research Other
Espiner, E. A., Rademaker, M. T., Charles, C. J., Kosoglou, T., Protter, A., Nicholls, M. G., & Richards, A. M. (1997). Inhibitory natriuretic peptide metabolism has beneficial renal hemodynamic effects, induces natriuresis and inhibits aldosterone in experimental heart failure. Verbal presentation at the 23rd Aldosterone Conference, Minneapolis. Conference Contribution - Verbal presentation and other Conference outputs
Pidgeon, G. B., Richards, A. M., Nicholls, M. G., Lewis, L. K., Yandle, T. G., Rademaker, M. T., Charles, C. J., … Lynn, K. (1997). Comparison of the effects of ouabain and brain natriuretic peptide in saline-loaded sheep. Proceedings of the 32nd Annual Meeting of Australian and New Zealand Society of Nephrology. 51, (pp. 1308). [Abstract] Conference Contribution - Published proceedings: Abstract
Charles, C. J., Rademaker, M. T., Richards, A. M., & Nicholls, M. G. (1997). Biological effects of intracerebroventricular adrenomedulin in normal conscious sheep. Proceedings of the Endocrine Society of Australia. 40, (pp. 16). [Abstract] Conference Contribution - Published proceedings: Abstract
Charles, C. J., Rogers, S. J., Donald, R. A., Ikram, H., Prickett, T., & Richards, A. M. (1997). Hypothalamo-pituitary-adrenal axis response in an ovibe model of acute myocardial infarction. Journal of Heart Failure. 4, (pp. 14). [Abstract] Conference Contribution - Published proceedings: Abstract
Pemberton, C. J., Yandle, T. G., Rademaker, M. T., Charles, C. J., Aitken, G. D., & Espiner, E. A. (1997). The Amino Terminal Fragment of ProBNP Circulates In Ovine Plasma. Proceedings of the Endocrine Society of Australia. 40, (pp. 48). Melbourne, Australia: The Endocrine Society of Australia. [Abstract] Conference Contribution - Published proceedings: Abstract
Rademaker, M. T., Charles, C. J., Kosoglou, T., Protter, A. A., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (1997). Clearance receptors and endopeptidase: equal role in natriuretic peptide metabolism in heart failure. American Journal of Physiology: Heart & Circulatory Physiology, 273(5 pt.2), H2372-H2379. Journal - Research Article
Pidgeon, G. B., Richards, A. M., Nicholls, M. G., Lewis, L. K., Yandle, T. G., Rademaker, M. T., Charles, C. J., … Lynn, K. L. (1997). Comparison of the effects of ouabain and brain natriuretic peptide in saline-loaded sheep. Clinical & Experimental Pharmacology & Physiology, 24(11), 807-813. Journal - Research Article
Charles, C. J., Rademaker, M. T., Richards, A. M., Cooper, G. J. S., Coy, D. H., Jing, N. N., & Nicholls, M. G. (1997). Hemodynamic, hormonal, and renal effects of adrenomedullin in conscious sheep. American Journal of Physiology: Regulatory, Integrative & Comparative Physiology, 272(6 pt.2), R2040-R2047. Journal - Research Article
Charles, C. J., Rogers, S. J., Donald, R. A., Ikram, H., Prickett, T., & Richards, A. M. (1997). Hypothalamo-pituitary-adrenal axis response to coronary artery embolization: An ovine model of acute myocardial infarction. Journal of Endocrinology, 152(3), 489-493. Journal - Research Article
Ikram, H., Rogers, S. J., Charles, C. J., Sands, J., Richards, A. M., Bridgman, P. G., & Gooneratne, R. (1997). An ovine model of acute myocardial infarction and chronic left ventricular dysfunction. Angiology, 48(8), 679-688. doi: 10.1177/000331979704800803 Journal - Research Article
Pemberton, C. J., Yandle, T. G., Charles, C. J., Rademaker, M. T., Aitken, G. D., & Espiner, E. A. (1997). Ovine brain natriuretic peptide in cardiac tissues and plasma: effects of cardiac hypertrophy and heart failure on tissue concentration and molecular forms. Journal of Endocrinology, 155(3), 541-550. Journal - Research Article
Rademaker, M. T., Charles, C. J., Lewis, L. K., Yandle, T. G., Cooper, G. J., Coy, D. H., Richards, A. M., & Nicholls, M. G. (1997). Beneficial hemodynamic and renal effects of adrenomedullin in an ovine model of heart failure. Circulation, 96(6), 1983-1990. Journal - Research Article
Rademaker, M. T., Charles, C. J., Espiner, E. A., Frampton, C. M., Nicholls, M. G., & Richards, A. M. (1997). Comparative bioactivity of atrial and brain natriuretic peptides in an ovine model of heart failure. Clinical Science, 92(2), 159-165. Journal - Research Article
Charles, C. J., Kaaja, R. J., Espiner, E. A., Nicholls, M. G., Pemberton, C. J., Richards, A. M., & Yandle, T. G. (1996). Natriuretic peptides in sheep with pressure overload left venticular hypertrophy. Clinical & Experimental Hypertension, 18(8), 1051-1071. Journal - Research Article
Charles, C. J., Espiner, E. A., Richards, A. M., Yandle, T. G., Nicholls, M. G., Protter, A., & Kosoglou, T. (1996). Clearance receptors and endopeptidase 24.11: equal role in natriuretic peptide metabolism in conscious sheep. American Journal of Physiology: Heart & Circulatory Physiology, 271, R373-R380. Journal - Research Article
Charles, C. J., Espiner, E. A., Yandle, T. G., Richards, A. M., & Nicholls, M. G. (1996). Comparative bioactivity of a trial, brain and C-type natriuretic peptides in conscious sheep. American Journal of Physiology: Regulatory, Integrative & Comparative Physiology, 270, R1324-R1331. Journal - Research Article
Pidgeon, G. B., Richards, A. M., Nicholls, M. G., Charles, C. J., Rademaker, M. T., Lynn, K. L., … Lewis, L. K., & Yandle, T. G. (1996). Chronic ouabain infusion does not cause hypertension in sheep. American Journal of Physiology: Endocrinology & Metabolism, 270(3), E386-E392. Journal - Research Article
Rademaker, M. T., Charles, C. J., Espiner, E. A., Frampton, C. M., Nicholls, M. G., Richards, A. M., & Yandle, T. G. (1996). Natriuretic peptide responses to acute and chronic ventricular pacing in sheep: evidence for differential secretion of ANP and BNP. American Journal of Physiology: Heart & Circulatory Physiology, 270, H594-H600. Journal - Research Article
Rademaker, M. T., Charles, C. J., Espiner, E. A., Nicholls, M. G., Richards, A. M., & Kosoglou, T. (1996). Neural endopeptidase inhibition: augmented atrial and brain natriuretic peptide, haemodynamic and natriuretic responses in ovine heart failure. Clinical Science, 91, 283-291. Journal - Research Article
Rademaker, M. T., Fitzpatrick, M. A., Charles, C. J., Richards, A. M., Nicholls, M. G., Espiner, E. A., & Sybertz, E. (1996). Comparison of chronic neutral endopeptidase inhibition and furosemide in an ovine model of heart failure. Journal of Cardiovascular Pharmacology, 27(3), 439-446. Journal - Research Article
Rademaker, M. T., Fitzpatrick, M. A., Richards, A. M., Charles, C. J., Nicholls, M. G., Frampton, C. M., & Ikram, H. (1996). Nitric oxide inhibition in an ovine model of heart failure. Clinical & Experimental Pharmacology & Physiology, 23, 403-409. Journal - Research Article
Rademaker, M. T., Fitzpatrick, M. A., Charles, C. J., Frampton, C. M., Richards, A. M., Nicholls, M. G., & Espiner, E. A. (1995). Central angiotensin II AT1-receptor antagonism in normal and heart failed sheep. American Journal of Physiology: Heart & Circulatory Physiology, 269, H425-H432. Journal - Research Article