Research interests
Moritz Lassé’s research focus is plasma proteomics.
His aim is to identify peptide and protein markers in blood that help predict future cardiovascular events in the general population or deterioration of renal function in heart failure patients.
Publications
Templeton, E. M., Pilbrow, A. P., Kleffmann, T., Pickering, J. W., Rademaker, M. T., Scott, N. J. A., Ellmers, L. J., Charles, C. J., Endre, Z. H., Richards, A. M., Cameron, V. A., & Lassé, M. (2023). Comparison of SPEED, S-Trap, and in-solution-based sample preparation methods for mass spectrometry in kidney tissue and plasma. International Journal of Molecular Sciences, 24(7), 6290. doi: 10.3390/ijms24076290
Wu, Z., Pilbrow, A. P., Liew, O. W., Chong, J. P. C., Sluyter, J., Lewis, L. K., Lasse, M., Frampton, C. M., … Cameron, V. A., … Richards, A. M. (2022). Circulating cardiac biomarkers improve risk stratification for incident cardiovascular disease in community dwelling populations. EBioMedicine, 82, 104170. doi: 10.1016/j.ebiom.2022.104170
Templeton, E., Lassé, M., Cameron, V., Pickering, J., Kleffmann, T., Hertzberg, D., Frampton, C., Ellmers, L., Palmer, S., … Scott, N., Charles, C., … Richards, M., … Troughton, R., Rademaker, M., & Pilbrow, A. (2022). Harnessing the power of 'Omics': Discovering novel microRNA and protein biomarkers of acute kidney injury in acute heart failure. Heart, Lung & Circulation, 31(Suppl. 2), (pp. S23-S24). doi: 10.1016/j.hlc.2022.05.009
Templeton, E. M., Lassé, M., Kleffmann, T., Ellmers, L. J., Palmer, S. C., Davidson, T., Scott, N. J. A., Pickering, J. W., Charles, C. J., Endre, Z. H., Cameron, V. A., Richards, A. M., Rademaker, M. T., & Pilbrow, A. P. (2022). Identifying candidate protein markers of acute kidney injury in acute decompensated heart failure. International Journal of Molecular Sciences, 23, 1009. doi: 10.3390/ijms23021009
Templeton, E., Lassé, M., Kleffmann, T., Ellmers, L. J., Palmer, S. C., Davidson, T., Scott, N. J., Pickering, J. W., Charles, C. J., Endre, Z. H., Cameron, V. A., & Richards, A. M. (2021). Identifying candidate protein markers of acute kidney injury in acute decompensated heart failure. Heart, Lung & Circulation, 30(Suppl. 2), (pp. S66). doi: 10.1016/j.hlc.2021.05.020
Lassé, M., Gerrard, J. A., & Pearce, F. G. (2012). Aggregation and fibrillogenesis of proteins not associated with disease: A few case studies. In J. R. Harris (Ed.), Protein aggregation and fibrillogenesis in cerebral and systemic amyloid disease. (pp. 253-270). Dordrecht, The Netherlands: Springer. doi: 10.1007/978-94-007-5416-4_11
Chapter in Book - Research
Templeton, E. M., Pilbrow, A. P., Kleffmann, T., Pickering, J. W., Rademaker, M. T., Scott, N. J. A., Ellmers, L. J., Charles, C. J., Endre, Z. H., Richards, A. M., Cameron, V. A., & Lassé, M. (2023). Comparison of SPEED, S-Trap, and in-solution-based sample preparation methods for mass spectrometry in kidney tissue and plasma. International Journal of Molecular Sciences, 24(7), 6290. doi: 10.3390/ijms24076290
Journal - Research Article
Templeton, E. M., Lassé, M., Kleffmann, T., Ellmers, L. J., Palmer, S. C., Davidson, T., Scott, N. J. A., Pickering, J. W., Charles, C. J., Endre, Z. H., Cameron, V. A., Richards, A. M., Rademaker, M. T., & Pilbrow, A. P. (2022). Identifying candidate protein markers of acute kidney injury in acute decompensated heart failure. International Journal of Molecular Sciences, 23, 1009. doi: 10.3390/ijms23021009
Journal - Research Article
Wu, Z., Pilbrow, A. P., Liew, O. W., Chong, J. P. C., Sluyter, J., Lewis, L. K., Lasse, M., Frampton, C. M., … Cameron, V. A., … Richards, A. M. (2022). Circulating cardiac biomarkers improve risk stratification for incident cardiovascular disease in community dwelling populations. EBioMedicine, 82, 104170. doi: 10.1016/j.ebiom.2022.104170
Journal - Research Article
Lassé, M., Pilbrow, A. P., Kleffmann, T., Andersson Överström, E., von Zychlinski, A., Frampton, C. M. A., … Troughton, R. W., Lewis, L. K., Prickett, T. C. R., Pemberton, C. J., Richards, A. M., & Cameron, V. A. (2021). Fibrinogen and hemoglobin predict near future cardiovascular events in asymptomatic individuals. Scientific Reports, 11(1), 4605. doi: 10.1038/s41598-021-84046-7
Journal - Research Article
Lassé, M., Stampfli, A. R., Orban, T., Seddon, K. A., Bothara, R. K., Gerrard, J. A., … Dobson, R. C. J. (2021). Reaction dynamics and residue identification of haemoglobin modification by acrolein, a lipid-peroxidation by-product. Biochimica et Biophysica Acta: General Subjects, 1865, 130013. doi: 10.1016/j.bbagen.2021.130013
Journal - Research Article
Lassé, M., Ulluwishewa, D., Healy, J., Thompson, D., Miller, A., Roy, N., Chitcholtan, K., & Gerrard, J. A. (2016). Evaluation of protease resistance and toxicity of amyloid-like food fibrils from whey, soy, kidney bean, and egg white. Food Chemistry, 192, 491-498. doi: 10.1016/j.foodchem.2015.07.044
Journal - Research Article
Poen, S., Nakatani, Y., Opel-Reading, H. K., Lassé, M., Dobson, R. C. J., & Krause, K. L. (2016). Exploring the structure of glutamate racemase from Mycobacterium tuberculosis as a template for anti-mycobacterial drug discovery. Biochemical Journal, 473, 1267-1280. doi: 10.1042/bcj20160186
Journal - Research Article
Lassé, M., Deb-Choudhury, S., Haines, S., Larsen, N., Gerrard, J. A., & Dyer, J. M. (2015). The impact of pH, salt concentration and heat on digestibility and amino acid modification in egg white protein. Journal of Food Composition & Analysis, 38, 42-48. doi: 10.1016/j.jfca.2014.08.007
Journal - Research Article
Crowther, J. M., Lassé, M., Suzuki, H., Kessans, S. A., Loo, T. S., Norris, G. E., … Dobson, R. C. J. (2014). Ultra-high resolution crystal structure of recombinant caprine β-lactoglobulin. FEBS Letters, 588(21), 3816-3822. doi: 10.1016/j.febslet.2014.09.010
Journal - Research Article
Kaur, M., Healy, J., Vasudevamurthy, M., Lassé, M., Puskar, L., Tobin, M. J., … Sasso, L. (2014). Stability and cytotoxicity of crystallin amyloid nanofibrils. Nanoscale, 6(21), 13169-13178. doi: 10.1039/C4NR04624B
Journal - Research Article
Benjamin, O., Lassé, M., Silcock, P., & Everett, D. W. (2012). Effect of pectin adsorption on the hydrophobic binding sites of β-lactoglobulin in solution and in emulsion systems. International Dairy Journal, 26(1), (pp. 36-40). doi: 10.1016/j.idairyj.2011.12.007
Conference Contribution - Published proceedings: Full paper
Gerrard, J. A., Lasse, M., Cottam, J., Healy, J. P., Fayle, S. E., Rasiah, I., … Larsen, N. G. (2012). Aspects of physical and chemical alterations to proteins during food processing: Some implications for nutrition. British Journal of Nutrition, 108(Suppl. 2), (pp. S288-S297). doi: 10.1017/S000711451200236X
Conference Contribution - Published proceedings: Full paper
Templeton, E., Lassé, M., Cameron, V., Pickering, J., Kleffmann, T., Hertzberg, D., Frampton, C., Ellmers, L., Palmer, S., … Scott, N., Charles, C., … Richards, M., … Troughton, R., Rademaker, M., & Pilbrow, A. (2022). Harnessing the power of 'Omics': Discovering novel microRNA and protein biomarkers of acute kidney injury in acute heart failure. Heart, Lung & Circulation, 31(Suppl. 2), (pp. S23-S24). doi: 10.1016/j.hlc.2022.05.009
Conference Contribution - Published proceedings: Abstract
Templeton, E., Lassé, M., Kleffmann, T., Ellmers, L. J., Palmer, S. C., Davidson, T., Scott, N. J., Pickering, J. W., Charles, C. J., Endre, Z. H., Cameron, V. A., & Richards, A. M. (2021). Identifying candidate protein markers of acute kidney injury in acute decompensated heart failure. Heart, Lung & Circulation, 30(Suppl. 2), (pp. S66). doi: 10.1016/j.hlc.2021.05.020
Conference Contribution - Published proceedings: Abstract