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Professor Zoltan H Endre

Zoltan Endre

MB BS, BSc(Med), PhD, FRACP

Email zoltan.endre@otago.ac.nz

Department of Medicine
University of Otago, Christchurch
PO Box 4345
Christchurch
New Zealand

Current Roles

  • Nephrologist
  • Deputy Editor-in-Chief, New Zealand: Internal Medicine Journal

Research Interests

  • Acute Renal Failure: Pathophysiology
  • Acute Renal Failure: Early Detection - Biomarkers
  • Acute Renal Failure: Apotposis, Growth Factors and Cell Survival Genes
  • Acute Renal Failure: Roles of Nitric Oxide and Oxygen-derived Free Radicals
  • Renal Endothelial Function: Roles of Nitric Oxide and Angiotensin II
  • Renal Endothelial Function: Haemodynamics and Modelling
  • Renal Endothelial Function: Progression of Renal Failure in Hypertension and Diabetes
  • Renal Applications of Magnetic Resonance Spectroscopy and Imaging

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Publications

Guiney, H., Walker, R., Broadbent, J., Caspi, A., Goodin, E., Kokaua, J., … Robertson, S., Theodore, R., Poulton, R., & Endre, Z. (2022). Kidney-function trajectories from young adulthood to midlife: Identifying risk strata and opportunities for intervention. Kidney International Reports. Advance online publication. doi: 10.1016/j.ekir.2022.10.005

Templeton, E. M., Lassé, M., Kleffmann, T., Ellmers, L. J., Palmer, S. C., Davidson, T., Scott, N. J. A., Pickering, J. W., Charles, C. J., Endre, Z. H., Cameron, V. A., Richards, A. M., Rademaker, M. T., & Pilbrow, A. P. (2022). Identifying candidate protein markers of acute kidney injury in acute decompensated heart failure. International Journal of Molecular Sciences, 23, 1009. doi: 10.3390/ijms23021009

Templeton, E., Lassé, M., Kleffmann, T., Ellmers, L. J., Palmer, S. C., Davidson, T., Scott, N. J., Pickering, J. W., Charles, C. J., Endre, Z. H., Cameron, V. A., & Richards, A. M. (2021). Identifying candidate protein markers of acute kidney injury in acute decompensated heart failure. Heart, Lung & Circulation, 30(Suppl. 2), (pp. S66). doi: 10.1016/j.hlc.2021.05.020

Rademaker, M. T., Pilbrow, A. P., Ellmers, L. J., Palmer, S. C., Davidson, T., Mbikou, P., Scott, N. J. A., Permina, E., Charles, C. J., Endre, Z. H., & Richards, A. M. (2021). Acute decompensated heart failure and the kidney: Physiological, histological and transcriptomic responses to development and recovery. Journal of the American Heart Association, 10, e021312. doi: 10.1161/jaha.121.021312

Endre, Z. H. (2018). Assessing renal recovery after acute kidney injury: Can biomarkers help? Nephrology, 140, 86-89. doi: 10.1159/000492290

Endre, Z. H., & Walker, R. J. (2017). Biomarkers of cardiovascular risk in chronic kidney disease. In C. L. Edelstein (Ed.), Biomarkers of kidney disease. (2nd ed.) (pp. 485-511). London, UK: Elsevier. doi: 10.1016/B978-0-12-803014-1.00011-X

Chapter in Book - Research

Walker, R. J., & Endre, Z. H. (2013). Cellular mechanisms of drug nephrotoxicity. In R. J. Alpern, O. W. Moe & M. Caplan (Eds.), Seldin and Giebisch's the kidney: Physiology and pathophysiology (Vol. 2). (5th ed.) (pp. 2889-2932). London, UK: Academic Press. doi: 10.1016/B978-0-12-381462-3.00085-9

Chapter in Book - Research

Endre, Z. H., & Robinson, J. (2012). Water, electrolytes, and acid-based balance. In J. Mann & A. S. Truswell (Eds.), Essentials of human nutrition. (4th ed.) (pp. 125-138). Oxford University Press.

Chapter in Book - Research

Pickering, J. W., & Endre, Z. H. (2012). The metamorphosis of acute renal failure to acute kidney injury. In M. Sahay (Ed.), Basic nephrology and acute kidney injury. (pp. 125-150). Rijeka, Croatia: InTech. doi: 10.5772/1298

Chapter in Book - Research

Endre, Z. H., & Edelstein, C. L. (2008). Animal models for the assessment of acute renal dysfunction and injury. In M. E. De Broe & G. A. Porter (Eds.), Clinical nephrotoxins: Renal injury from drugs and chemicals. (3rd ed.) (pp. 173-222). US: Springer. doi: 10.1007/978-0-387-84843-3

Chapter in Book - Research

Walker, R. J., & Endre, Z. H. (2008). Cellular mechanisms of drug nephrotoxicity. In R. J. Alpern & S. C. Hebert (Eds.), Seldin and Giebisch's: The kidney: Physiology and pathophysiology (Vols. 1-2). (4th ed.) (pp. 2507-2536). Burlington, MA: Academic Press.

Chapter in Book - Research

Endre, Z. (2007). Hyponatraemia. In D. C. Harris & Colleagues (Eds.), Clinical cases in kidney disease. (pp. 3-24). Sydney, Australia: McGraw-Hill.

Chapter in Book - Research

Melnikov, V. Y., Endre, Z. H., & Edelstein, C. L. (2003). Animal models for the assessment of acute renal dysfunction and injury. In M. E. De Broe, G. A. Porter, W. M. Bennett & G. A. Verpooten (Eds.), Clinical nephrotoxins: Renal injury from drugs and chemicals. (2nd ed.) (pp. 77-114). Dordrecht, The Netherlands: Kluwer Academic.

Chapter in Book - Research

Guiney, H., Walker, R., Broadbent, J., Caspi, A., Goodin, E., Kokaua, J., … Robertson, S., Theodore, R., Poulton, R., & Endre, Z. (2022). Kidney-function trajectories from young adulthood to midlife: Identifying risk strata and opportunities for intervention. Kidney International Reports. Advance online publication. doi: 10.1016/j.ekir.2022.10.005

Journal - Research Article

Templeton, E. M., Lassé, M., Kleffmann, T., Ellmers, L. J., Palmer, S. C., Davidson, T., Scott, N. J. A., Pickering, J. W., Charles, C. J., Endre, Z. H., Cameron, V. A., Richards, A. M., Rademaker, M. T., & Pilbrow, A. P. (2022). Identifying candidate protein markers of acute kidney injury in acute decompensated heart failure. International Journal of Molecular Sciences, 23, 1009. doi: 10.3390/ijms23021009

Journal - Research Article

Rademaker, M. T., Pilbrow, A. P., Ellmers, L. J., Palmer, S. C., Davidson, T., Mbikou, P., Scott, N. J. A., Permina, E., Charles, C. J., Endre, Z. H., & Richards, A. M. (2021). Acute decompensated heart failure and the kidney: Physiological, histological and transcriptomic responses to development and recovery. Journal of the American Heart Association, 10, e021312. doi: 10.1161/jaha.121.021312

Journal - Research Article

Mohamed, F., Buckley, N. A., Pickering, J. W., Wunnapuk, K., Dissanayake, S., Chathuranga, U., … Endre, Z. H. (2017). Nephrotoxicity-induced proteinuria increases biomarker diagnostic thresholds in acute kidney injury. BMC Nephrology, 18(1), 122. doi: 10.1186/s12882-017-0532-7

Journal - Research Article

Pianta, T. J., Pickering, J. W., Succar, L., Chin, M., Davidson, T., Buckley, N. A., … Endre, Z. H. (2017). Dexamethasone modifies cystatin C-based diagnosis of acute kidney injury during cisplatin-based chemotherapy. Kidney & Blood Pressure Research, 62-75. doi: 10.1159/000469715

Journal - Research Article

Puckett, J. R., Pickering, J. W., Palmer, S. C., McCall, J. L., Kluger, M. T., De Zoysa, J., Endre, Z. H., & Soop, M. (2017). Low versus standard urine output targets in patients undergoing major abdominal surgery: A randomized noninferiority trial. Annals of Surgery, 265(5), 874-881. doi: 10.1097/sla.0000000000002044

Journal - Research Article

Succar, L., Pianta, T. J., Davidson, T., Pickering, J. W., & Endre, Z. H. (2017). Subclinical chronic kidney disease modifies the diagnosis of experimental acute kidney injury. Kidney International, 92(3), 680-692. doi: 10.1016/j.kint.2017.02.030

Journal - Research Article

Teo, S. H., & Endre, Z. H. (2017). Biomarkers in acute kidney injury (AKI). Best Practice & Research: Clinical Anaesthesiology, 31(3), 331-344. doi: 10.1016/j.bpa.2017.10.003

Journal - Research Article

Endre, Z. H., Pianta, T. J., & Pickering, J. W. (2016). Timely diagnosis of acute kidney injury using kinetic eGFR and the creatinine excretion to production ratio, E/eG: Creatinine can be useful! Nephron Clinical Practice, 132, 312-316. doi: 10.1159/000444456

Journal - Research Article

Mohamed, F., Endre, Z. H., Pickering, J. W., Jayamanne, S., Palangasinghe, C., Shahmy, S., … Buckley, N. A. (2016). Mechanism-specific injury biomarkers predict nephrotoxicity early following glyphosate surfactant herbicide (GPSH) poisoning. Toxicology Letters, 258, 1-10. doi: 10.1016/j.toxlet.2016.06.001

Journal - Research Article

Pickering, J. W., & Endre, Z. H. (2016). Bench to bedside: The next steps for biomarkers in acute kidney injury. American Journal of Physiology: Renal Physiology, 311(4), F717-F721. doi: 10.1152/ajprenal.00268.2016

Journal - Research Article

Wang, M. H., Chong, K. C., Storer, M., Pickering, J. W., Endre, Z. H., Lau, S. Y. F., … Zee, B. C. Y. (2016). Use of a least absolute shrinkage and selection operator (LASSO) model to selected ion flow tube mass spectrometry (SIFT-MS) analysis of exhaled breath to predict the efficacy of dialysis: A pilot study. Journal of Breath Research, 10(4), 046004. doi: 10.1088/1752-7155/10/4/046004

Journal - Research Article

Chew-Harris, J. S. C., Chin, P. K. L., Florkowski, C. M., George, P., & Endre, Z. (2015). Removal of body surface area normalisation improves raw-measured glomerular filtration rate estimation by the Chronic Kidney Disease Epidemiology Collaboration equation and drug dosing in the obese. Internal Medicine Journal, 45(7), 766-773. doi: 10.1111/imj.12791

Journal - Research Article

Chew-Harris, J. S. C., Florkowski, C. M., George, P. M., & Endre, Z. H. (2015). Comparative performances of the new chronic kidney disease epidemiology equations incorporating cystatin C for use in cancer patients. Asia-Pacific Journal of Clinical Oncology, 11(2), 142-151. doi: 10.1111/ajco.12312

Journal - Research Article

Mohamed, F., Buckley, N. A., Jayamanne, S., Pickering, J. W., Peake, P., Palangasinghe, C., … Endre, Z. H. (2015). Kidney damage biomarkers detect acute kidney injury but only functional markers predict mortality after paraquat ingestion. Toxicology Letters, 237(2), 140-150. doi: 10.1016/j.toxlet.2015.06.008

Journal - Research Article

Pianta, T. J., Endre, Z. H., Pickering, J. W., Buckley, N. A., & Peake, P. W. (2015). Kinetic estimation of GFR improves prediction of dialysis and recovery after kidney transplantation. PLoS ONE, 10(5), e0125669. doi: 10.1371/journal.pone.0125669

Journal - Research Article

Pianta, T. J., Peake, P. W., Pickering, J. W., Kelleher, M., Buckley, N. A., & Endre, Z. H. (2015). Evaluation of biomarkers of cell cycle arrest and inflammation in prediction of dialysis or recovery after kidney transplantation. Transplant International, 28(12), 1392-1404. doi: 10.1111/tri.12636

Journal - Research Article

Pianta, T. J., Peake, P. W., Pickering, J. W., Kelleher, M., Buckley, N. A., & Endre, Z. H. (2015). Clusterin in kidney transplantation: Novel biomarkers versus serum creatinine for early prediction of delayed graft function. Transplantation, 99(1), 171-179. doi: 10.1097/tp.0000000000000256

Journal - Research Article

Takaki, S., Shehabi, Y., Pickering, J. W., Endre, Z., Miyashita, T., & Goto, T. (2015). Perioperative change in creatinine following cardiac surgery with cardiopulmonary bypass is useful in predicting acute kidney injury: A single-centre retrospective cohort study. Interactive Cardiovascular & Thoracic Surgery, 21(4), 465-469. doi: 10.1093/icvts/ivv184

Journal - Research Article

Chew-Harris, J. S. C., Florkowski, C. M., Elmslie, J. L., Livesey, J., Endre, Z. H., & George, P. M. (2014). Lean mass modulates glomerular filtration rate in males of normal and extreme body composition. Internal Medicine Journal, 44(8), 749-756. doi: 10.1111/imj.12479

Journal - Research Article

Endre, Z. H. (2014). Using biomarkers for acute kidney injury: Barriers and solutions. Nephron Clinical Practice, 127(1-4), 180-184. doi: 10.1159/000363555

Journal - Research Article

Pickering, J. W., & Endre, Z. H. (2014). Acute kidney injury urinary biomarker time-courses. PLoS ONE, 9(7), e101288. doi: 10.1371/journal.pone.0101288

Journal - Research Article

Ralib, A. M., Pickering, J. W., Shaw, G. M., Than, M. P., George, P. M., & Endre, Z. H. (2014). The clinical utility window for acute kidney injury biomarkers in the critically ill. Critical Care, 18, 601. doi: 10.1186/s13054-014-0601-2

Journal - Research Article

Chew-Harris, J. S. C., Florkowski, C. M., George, P. M., Elmslie, J. L., & Endre, Z. H. (2013). The relative effects of fat versus muscle mass on cystatin C and estimates of renal function in healthy young men. Annals of Clinical Biochemistry, 50(1), 39-46. doi: 10.1258/acb.2012.011241

Journal - Research Article

Endre, Z. H., & Pickering, J. W. (2013). Acute kidney injury clinical trial design: Old problems, new strategies. Pediatric Nephrology, 28(2), 207-217. doi: 10.1007/s00467-012-2171-3

Journal - Research Article

Md Ralib, A., Pickering, J. W., Shaw, G. M., & Endre, Z. H. (2013). The urine output definition of acute kidney injury is too liberal. Critical Care, 17, R112. doi: 10.1186/cc12784

Journal - Research Article

Pianta, T. J., Buckley, N. A., Peake, P., & Endre, Z. H. (2013). Clinical use of biomarkers for toxicant-induced acute kidney injury. Biomarkers in Medicine, 7(3), 441-456. doi: 10.2217/bmm.13.51

Journal - Research Article

Pickering, J. W., & Endre, Z. H. (2013). Linking injury to outcome in acute kidney injury: A matter of sensitivity. PLoS ONE, 8(4), e62691. doi: 10.1371/journal.pone.0062691

Journal - Research Article

Pickering, J. W., & Endre, Z. H. (2013). The clinical utility of plasma neutrophil gelatinase-associated lipocalin in acute kidney injury. Blood Purification, 35(4), 295-302. doi: 10.1159/000351542

Journal - Research Article

Pickering, J. W., Ralib, A. M., & Endre, Z. H. (2013). Combining creatinine and volume kinetics identifies missed cases of acute kidney injury following cardiac arrest. Critical Care, 17, R7. doi: 10.1186/cc11931

Journal - Research Article

Ralib, A. M., Pickering, J. W., Major, T., Palmer, S. C., Shaw, G. M., Goodkin, D. A., & Endre, Z. H. (2013). High-dose intravenous epoetin does not increase blood pressure in critically ill patients with acute kidney injury. Clinical Nephrology, 79(5), 370-379. doi: 10.5414/cn107673

Journal - Research Article

Md Ralib, A., Pickering, J. W., Shaw, G. M., Devarajan, P., Edelstein, C. L., Bonventre, J. V., & Endre, Z. H. (2012). Test characteristics of urinary biomarkers depend on quantitation method in acute kidney injury. Journal of the American Society of Nephrology, 23(2), 322-333. doi: 10.1681/asn.2011040325

Journal - Research Article

Nejat, M., Hill, J. V., Pickering, J. W., Edelstein, C. L., Devarajan, P., & Endre, Z. H. (2012). Albuminuria increases cystatin C excretion: Implications for urinary biomarkers. Nephrology Dialysis Transplantation, 27(Suppl. 3), iii96-iii103. doi: 10.1093/ndt/gfr222

Journal - Research Article

Nejat, M., Pickering, J. W., Devarajan, P., Bonventre, J. V., Edelstein, C. L., Walker, R. J., & Endre, Z. H. (2012). Some biomarkers of acute kidney injury are increased in pre-renal acute injury. Kidney International, 81, 1254-1262. doi: 10.1038/ki.2012.23

Journal - Research Article

Pickering, J. W., & Endre, Z. H. (2012). Challenges facing early detection of acute kidney injury in the critically ill. World Journal of Critical Care Medicine, 1(3), 61-66. doi: 10.5492/wjccm.v1.i3.61

Journal - Research Article

Pickering, J. W., & Endre, Z. H. (2012). New metrics for assessing diagnostic potential of candidate biomarkers. Clinical Journal of the American Society of Nephrology, 7(8), 1355-1364. doi: 10.2215/cjn.09590911

Journal - Research Article

Pickering, J. W., Frampton, C. M., Walker, R. J., Shaw, G. M., & Endre, Z. H. (2012). Four hour creatinine clearance is better than plasma creatinine for monitoring renal function in critically ill patients. Critical Care, 16, R107. doi: 10.1186/cc11391

Journal - Research Article

Endre, Z. H., & Pickering, J. W. (2011). New markers of acute kidney injury: Giant leaps and baby steps. Clinical Biochemist Reviews, 32(2), 121-124.

Journal - Research Article

Endre, Z. H., Pickering, J. W., & Walker, R. J. (2011). Clearance and beyond: The complementary roles of GFR measurement and injury biomarkers in acute kidney injury (AKI). American Journal of Physiology: Renal Physiology, 301(4), F697-F707. doi: 10.1152/ajprenal.00448.2010

Journal - Research Article

Endre, Z. H., Pickering, J. W., Walker, R. J., Devarajan, P., Edelstein, C. L., Bonventre, J. V., Frampton, C. M., … Shaw, G. M., Henderson, S. J., Nejat, M., Schollum, J. B. W., & George, P. M. (2011). Improved performance of urinary biomarkers of acute kidney injury in the critically ill by stratification for injury duration and baseline renal function. Kidney International, 79, 1119-1130. doi: 10.1038/ki.2010.555

Journal - Research Article

Moorhead, K. T., Hill, J. V., Chase, J. G., Hann, C. E., Scotter, J. M., Storer, M. K., & Endre, Z. H. (2011). Modelling acute renal failure using blood and breath biomarkers in rats. Computer Methods & Programs in Biomedicine, 101(2), 173-182. doi: 10.1016/j.cmpb.2010.07.010

Journal - Research Article

Moya-Olano, L., Milne, H. M., Robinson, J. M., Hill, J. V., Frampton, C. M., Abbott, H. F., Turner, R., Kettle, A. J., & Endre, Z. H. (2011). Trientine and renin-angiotensin system blockade ameliorate progression of glomerular morphology in hypertensive experimental diabetic nephropathy. Pathology International, 61(11), 652-661. doi: 10.1111/j.1440-1827.2011.02721.x

Journal - Research Article

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