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Professor Zoltan H Endre

Zoltan Endre

MB BS, BSc(Med), PhD, FRACP

Email zoltan.endre@otago.ac.nz

Department of Medicine
University of Otago, Christchurch
PO Box 4345
Christchurch
New Zealand

Current Roles

  • Nephrologist
  • Deputy Editor-in-Chief, New Zealand: Internal Medicine Journal

Research Interests

  • Acute Renal Failure: Pathophysiology
  • Acute Renal Failure: Early Detection - Biomarkers
  • Acute Renal Failure: Apotposis, Growth Factors and Cell Survival Genes
  • Acute Renal Failure: Roles of Nitric Oxide and Oxygen-derived Free Radicals
  • Renal Endothelial Function: Roles of Nitric Oxide and Angiotensin II
  • Renal Endothelial Function: Haemodynamics and Modelling
  • Renal Endothelial Function: Progression of Renal Failure in Hypertension and Diabetes
  • Renal Applications of Magnetic Resonance Spectroscopy and Imaging

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Publications

Endre, Z. H., & Walker, R. J. (2017). Biomarkers of cardiovascular risk in chronic kidney disease. In C. L. Edelstein (Ed.), Biomarkers of kidney disease. (2nd ed.) (pp. 485-511). London, UK: Elsevier. doi: 10.1016/B978-0-12-803014-1.00011-X

Mohamed, F., Buckley, N. A., Pickering, J. W., Wunnapuk, K., Dissanayake, S., Chathuranga, U., … Endre, Z. H. (2017). Nephrotoxicity-induced proteinuria increases biomarker diagnostic thresholds in acute kidney injury. BMC Nephrology, 18(1), 122. doi: 10.1186/s12882-017-0532-7

Teo, S. H., & Endre, Z. H. (2017). Biomarkers in acute kidney injury (AKI). Best Practice & Research: Clinical Anaesthesiology, 31(3), 331-344. doi: 10.1016/j.bpa.2017.10.003

Pianta, T. J., Pickering, J. W., Succar, L., Chin, M., Davidson, T., Buckley, N. A., … Endre, Z. H. (2017). Dexamethasone modifies cystatin C-based diagnosis of acute kidney injury during cisplatin-based chemotherapy. Kidney & Blood Pressure Research, 62-75. doi: 10.1159/000469715

Puckett, J. R., Pickering, J. W., Palmer, S. C., McCall, J. L., Kluger, M. T., De Zoysa, J., Endre, Z. H., & Soop, M. (2017). Low versus standard urine output targets in patients undergoing major abdominal surgery: A randomized noninferiority trial. Annals of Surgery, 265(5), 874-881. doi: 10.1097/sla.0000000000002044

Chapter in Book - Research

Endre, Z. H., & Walker, R. J. (2017). Biomarkers of cardiovascular risk in chronic kidney disease. In C. L. Edelstein (Ed.), Biomarkers of kidney disease. (2nd ed.) (pp. 485-511). London, UK: Elsevier. doi: 10.1016/B978-0-12-803014-1.00011-X

Walker, R. J., & Endre, Z. H. (2013). Cellular mechanisms of drug nephrotoxicity. In R. J. Alpern, O. W. Moe & M. Caplan (Eds.), Seldin and Giebisch's the kidney: Physiology and pathophysiology (Vol. 2). (5th ed.) (pp. 2889-2932). London, UK: Academic Press. doi: 10.1016/B978-0-12-381462-3.00085-9

Pickering, J. W., & Endre, Z. H. (2012). The metamorphosis of acute renal failure to acute kidney injury. In M. Sahay (Ed.), Basic nephrology and acute kidney injury. (pp. 125-150). Rijeka, Croatia: InTech. doi: 10.5772/1298

Endre, Z. H., & Robinson, J. (2012). Water, electrolytes, and acid-based balance. In J. Mann & A. S. Truswell (Eds.), Essentials of human nutrition. (4th ed.) (pp. 125-138). Oxford University Press.

Walker, R. J., & Endre, Z. H. (2008). Cellular mechanisms of drug nephrotoxicity. In R. J. Alpern & S. C. Hebert (Eds.), Seldin and Giebisch's: The kidney: Physiology and pathophysiology (Vols. 1-2). (4th ed.) (pp. 2507-2536). Burlington, MA: Academic Press.

Endre, Z. H., & Edelstein, C. L. (2008). Animal models for the assessment of acute renal dysfunction and injury. In M. E. De Broe & G. A. Porter (Eds.), Clinical nephrotoxins: Renal injury from drugs and chemicals. (3rd ed.) (pp. 173-222). US: Springer. doi: 10.1007/978-0-387-84843-3

Endre, Z. (2007). Hyponatraemia. In D. C. Harris & Colleagues (Eds.), Clinical cases in kidney disease. (pp. 3-24). Sydney, Australia: McGraw-Hill.

Melnikov, V. Y., Endre, Z. H., & Edelstein, C. L. (2003). Animal models for the assessment of acute renal dysfunction and injury. In M. E. De Broe, G. A. Porter, W. M. Bennett & G. A. Verpooten (Eds.), Clinical nephrotoxins: Renal injury from drugs and chemicals. (2nd ed.) (pp. 77-114). Dordrecht, The Netherlands: Kluwer Academic.

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Journal - Research Article

Mohamed, F., Buckley, N. A., Pickering, J. W., Wunnapuk, K., Dissanayake, S., Chathuranga, U., … Endre, Z. H. (2017). Nephrotoxicity-induced proteinuria increases biomarker diagnostic thresholds in acute kidney injury. BMC Nephrology, 18(1), 122. doi: 10.1186/s12882-017-0532-7

Puckett, J. R., Pickering, J. W., Palmer, S. C., McCall, J. L., Kluger, M. T., De Zoysa, J., Endre, Z. H., & Soop, M. (2017). Low versus standard urine output targets in patients undergoing major abdominal surgery: A randomized noninferiority trial. Annals of Surgery, 265(5), 874-881. doi: 10.1097/sla.0000000000002044

Pianta, T. J., Pickering, J. W., Succar, L., Chin, M., Davidson, T., Buckley, N. A., … Endre, Z. H. (2017). Dexamethasone modifies cystatin C-based diagnosis of acute kidney injury during cisplatin-based chemotherapy. Kidney & Blood Pressure Research, 62-75. doi: 10.1159/000469715

Teo, S. H., & Endre, Z. H. (2017). Biomarkers in acute kidney injury (AKI). Best Practice & Research: Clinical Anaesthesiology, 31(3), 331-344. doi: 10.1016/j.bpa.2017.10.003

Succar, L., Pianta, T. J., Davidson, T., Pickering, J. W., & Endre, Z. H. (2017). Subclinical chronic kidney disease modifies the diagnosis of experimental acute kidney injury. Kidney International, 92(3), 680-692. doi: 10.1016/j.kint.2017.02.030

Mohamed, F., Endre, Z. H., Pickering, J. W., Jayamanne, S., Palangasinghe, C., Shahmy, S., … Buckley, N. A. (2016). Mechanism-specific injury biomarkers predict nephrotoxicity early following glyphosate surfactant herbicide (GPSH) poisoning. Toxicology Letters, 258, 1-10. doi: 10.1016/j.toxlet.2016.06.001

Pickering, J. W., & Endre, Z. H. (2016). Bench to bedside: The next steps for biomarkers in acute kidney injury. American Journal of Physiology: Renal Physiology, 311(4), F717-F721. doi: 10.1152/ajprenal.00268.2016

Endre, Z. H., Pianta, T. J., & Pickering, J. W. (2016). Timely diagnosis of acute kidney injury using kinetic eGFR and the creatinine excretion to production ratio, E/eG: Creatinine can be useful! Nephron Clinical Practice, 132, 312-316. doi: 10.1159/000444456

Wang, M. H., Chong, K. C., Storer, M., Pickering, J. W., Endre, Z. H., Lau, S. Y. F., … Zee, B. C. Y. (2016). Use of a least absolute shrinkage and selection operator (LASSO) model to selected ion flow tube mass spectrometry (SIFT-MS) analysis of exhaled breath to predict the efficacy of dialysis: A pilot study. Journal of Breath Research, 10(4), 046004. doi: 10.1088/1752-7155/10/4/046004

Pianta, T. J., Endre, Z. H., Pickering, J. W., Buckley, N. A., & Peake, P. W. (2015). Kinetic estimation of GFR improves prediction of dialysis and recovery after kidney transplantation. PLoS ONE, 10(5), e0125669. doi: 10.1371/journal.pone.0125669

Pianta, T. J., Peake, P. W., Pickering, J. W., Kelleher, M., Buckley, N. A., & Endre, Z. H. (2015). Evaluation of biomarkers of cell cycle arrest and inflammation in prediction of dialysis or recovery after kidney transplantation. Transplant International, 28(12), 1392-1404. doi: 10.1111/tri.12636

Pianta, T. J., Peake, P. W., Pickering, J. W., Kelleher, M., Buckley, N. A., & Endre, Z. H. (2015). Clusterin in kidney transplantation: Novel biomarkers versus serum creatinine for early prediction of delayed graft function. Transplantation, 99(1), 171-179. doi: 10.1097/tp.0000000000000256

Takaki, S., Shehabi, Y., Pickering, J. W., Endre, Z., Miyashita, T., & Goto, T. (2015). Perioperative change in creatinine following cardiac surgery with cardiopulmonary bypass is useful in predicting acute kidney injury: A single-centre retrospective cohort study. Interactive Cardiovascular & Thoracic Surgery, 21(4), 465-469. doi: 10.1093/icvts/ivv184

Chew-Harris, J. S. C., Chin, P. K. L., Florkowski, C. M., George, P., & Endre, Z. (2015). Removal of body surface area normalisation improves raw-measured glomerular filtration rate estimation by the Chronic Kidney Disease Epidemiology Collaboration equation and drug dosing in the obese. Internal Medicine Journal, 45(7), 766-773. doi: 10.1111/imj.12791

Mohamed, F., Buckley, N. A., Jayamanne, S., Pickering, J. W., Peake, P., Palangasinghe, C., … Endre, Z. H. (2015). Kidney damage biomarkers detect acute kidney injury but only functional markers predict mortality after paraquat ingestion. Toxicology Letters, 237(2), 140-150. doi: 10.1016/j.toxlet.2015.06.008

Chew-Harris, J. S. C., Florkowski, C. M., George, P. M., & Endre, Z. H. (2015). Comparative performances of the new chronic kidney disease epidemiology equations incorporating cystatin C for use in cancer patients. Asia-Pacific Journal of Clinical Oncology, 11(2), 142-151. doi: 10.1111/ajco.12312

Chew-Harris, J. S. C., Florkowski, C. M., Elmslie, J. L., Livesey, J., Endre, Z. H., & George, P. M. (2014). Lean mass modulates glomerular filtration rate in males of normal and extreme body composition. Internal Medicine Journal, 44(8), 749-756. doi: 10.1111/imj.12479

Endre, Z. H. (2014). Using biomarkers for acute kidney injury: Barriers and solutions. Nephron Clinical Practice, 127(1-4), 180-184. doi: 10.1159/000363555

Pickering, J. W., & Endre, Z. H. (2014). Acute kidney injury urinary biomarker time-courses. PLoS ONE, 9(7), e101288. doi: 10.1371/journal.pone.0101288

Ralib, A. M., Pickering, J. W., Shaw, G. M., Than, M. P., George, P. M., & Endre, Z. H. (2014). The clinical utility window for acute kidney injury biomarkers in the critically ill. Critical Care, 18, 601. doi: 10.1186/s13054-014-0601-2

Pianta, T. J., Buckley, N. A., Peake, P., & Endre, Z. H. (2013). Clinical use of biomarkers for toxicant-induced acute kidney injury. Biomarkers in Medicine, 7(3), 441-456. doi: 10.2217/bmm.13.51

Ralib, A. M., Pickering, J. W., Major, T., Palmer, S. C., Shaw, G. M., Goodkin, D. A., & Endre, Z. H. (2013). High-dose intravenous epoetin does not increase blood pressure in critically ill patients with acute kidney injury. Clinical Nephrology, 79(5), 370-379. doi: 10.5414/cn107673

Md Ralib, A., Pickering, J. W., Shaw, G. M., & Endre, Z. H. (2013). The urine output definition of acute kidney injury is too liberal. Critical Care, 17, R112. doi: 10.1186/cc12784

Pickering, J. W., & Endre, Z. H. (2013). The clinical utility of plasma neutrophil gelatinase-associated lipocalin in acute kidney injury. Blood Purification, 35(4), 295-302. doi: 10.1159/000351542

Pickering, J. W., Ralib, A. M., & Endre, Z. H. (2013). Combining creatinine and volume kinetics identifies missed cases of acute kidney injury following cardiac arrest. Critical Care, 17, R7. doi: 10.1186/cc11931

Endre, Z. H., & Pickering, J. W. (2013). Acute kidney injury clinical trial design: Old problems, new strategies. Pediatric Nephrology, 28(2), 207-217. doi: 10.1007/s00467-012-2171-3

Pickering, J. W., & Endre, Z. H. (2013). Linking injury to outcome in acute kidney injury: A matter of sensitivity. PLoS ONE, 8(4), e62691. doi: 10.1371/journal.pone.0062691

Chew-Harris, J. S. C., Florkowski, C. M., George, P. M., Elmslie, J. L., & Endre, Z. H. (2013). The relative effects of fat versus muscle mass on cystatin C and estimates of renal function in healthy young men. Annals of Clinical Biochemistry, 50(1), 39-46. doi: 10.1258/acb.2012.011241

Nejat, M., Hill, J. V., Pickering, J. W., Edelstein, C. L., Devarajan, P., & Endre, Z. H. (2012). Albuminuria increases cystatin C excretion: Implications for urinary biomarkers. Nephrology Dialysis Transplantation, 27(Suppl. 3), iii96-iii103. doi: 10.1093/ndt/gfr222

Pickering, J. W., & Endre, Z. H. (2012). New metrics for assessing diagnostic potential of candidate biomarkers. Clinical Journal of the American Society of Nephrology, 7(8), 1355-1364. doi: 10.2215/cjn.09590911

Pickering, J. W., & Endre, Z. H. (2012). Challenges facing early detection of acute kidney injury in the critically ill. World Journal of Critical Care Medicine, 1(3), 61-66. doi: 10.5492/wjccm.v1.i3.61

Pickering, J. W., Frampton, C. M., Walker, R. J., Shaw, G. M., & Endre, Z. H. (2012). Four hour creatinine clearance is better than plasma creatinine for monitoring renal function in critically ill patients. Critical Care, 16, R107. doi: 10.1186/cc11391

Nejat, M., Pickering, J. W., Devarajan, P., Bonventre, J. V., Edelstein, C. L., Walker, R. J., & Endre, Z. H. (2012). Some biomarkers of acute kidney injury are increased in pre-renal acute injury. Kidney International, 81, 1254-1262. doi: 10.1038/ki.2012.23

Md Ralib, A., Pickering, J. W., Shaw, G. M., Devarajan, P., Edelstein, C. L., Bonventre, J. V., & Endre, Z. H. (2012). Test characteristics of urinary biomarkers depend on quantitation method in acute kidney injury. Journal of the American Society of Nephrology, 23(2), 322-333. doi: 10.1681/asn.2011040325

Pickering, J. W., Md Ralib, A., Nejat, M., & Endre, Z. (2011). New considerations in the design of clinical trials of acute kidney injury. Clinical Investigation, 1(5), 637-650. doi: 10.4155/CLI.11.38

Moya-Olano, L., Milne, H. M., Robinson, J. M., Hill, J. V., Frampton, C. M., Abbott, H. F., Turner, R., Kettle, A. J., & Endre, Z. H. (2011). Trientine and renin-angiotensin system blockade ameliorate progression of glomerular morphology in hypertensive experimental diabetic nephropathy. Pathology International, 61(11), 652-661. doi: 10.1111/j.1440-1827.2011.02721.x

Endre, Z. H., & Pickering, J. W. (2011). New markers of acute kidney injury: Giant leaps and baby steps. Clinical Biochemist Reviews, 32(2), 121-124.

Endre, Z. H., Pickering, J. W., & Walker, R. J. (2011). Clearance and beyond: The complementary roles of GFR measurement and injury biomarkers in acute kidney injury (AKI). American Journal of Physiology: Renal Physiology, 301(4), F697-F707. doi: 10.1152/ajprenal.00448.2010

Endre, Z. H., Pickering, J. W., Walker, R. J., Devarajan, P., Edelstein, C. L., Bonventre, J. V., Frampton, C. M., … Shaw, G. M., Henderson, S. J., Nejat, M., Schollum, J. B. W., & George, P. M. (2011). Improved performance of urinary biomarkers of acute kidney injury in the critically ill by stratification for injury duration and baseline renal function. Kidney International, 79, 1119-1130. doi: 10.1038/ki.2010.555

Moorhead, K. T., Hill, J. V., Chase, J. G., Hann, C. E., Scotter, J. M., Storer, M. K., & Endre, Z. H. (2011). Modelling acute renal failure using blood and breath biomarkers in rats. Computer Methods & Programs in Biomedicine, 101(2), 173-182. doi: 10.1016/j.cmpb.2010.07.010

Endre, Z. H., Walker, R. J., Pickering, J. W., Shaw, G. M., Frampton, C. M., Henderson, S. J., Hutchison, R., … Robinson, J. M., Schollum, J. B. W., … Celi, L. A., … George, P. M. (2010). Early intervention with erythropoietin does not affect the outcome of acute kidney injury (the EARLYARF trial). Kidney International, 77, 1020-1030. doi: 10.1038/ki.2010.25

Endre, Z. H., & Pickering, J. W. (2010). Outcome definitions in non-dialysis intervention and prevention trials in acute kidney injury (AKI). Nephrology Dialysis Transplantation, 25(1), 107-118. doi: 10.1093/ndt/gfp501

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