Professor
BA (Massey) MB ChB (Otago) MD(Otago,) PhD(Otago) DSc (Otago) FRACP FRCP FRSNZ
Department of Medicine
University of Otago, Christchurch
PO Box 4345
Christchurch
New Zealand
Mark Richards is the director of the Christchurch Heart Institute.
He coordinates and directs multi-disciplinary programmes of grant-funded translational cardiovascular research which seek to improve diagnostic, prognostic and therapeutic options in heart disease.
He is pursuing studies of epidemiological, molecular biological, neurohormonal and therapeutic aspects of acute and chronic cardiovascular disorders including hypertension, coronary syndromes, and the full spectrum of heart failure.
Richards holds the Heart Foundation of New Zealand’s Chair in Cardiovascular Studies.
He also holds joint appointments at the University of Otago and the National University of Singapore’s Cardiovascular Research Institute.
Email mdcarthu@nus.edu.sg (University of Singapore)
Current roles
- Director, The Christchurch Heart Institute
- Consultant Cardiologist, The Canterbury District Health Board
Research interests
- Neurohormonal physiology and pathophysiology in cardiovascular health and disease
- Heart Failure
- Acute Coronary Syndromes
- Hypertension
- Vasoactive Hormones
- The Cardiac Natriuretic Peptides
Publications
Aimo, A., Januzzi, Jr, J. L., Vergaro, G., Richards, A. M., Lam, C. S. P., Latini, R., … Troughton, R., … Edmin, M. (2020). Circulating levels and prognostic value of soluble ST2 in heart failure are less influenced by age than N-terminal pro-B-type natriuretic peptide and high-sensitivity troponin T. European Journal of Heart Failure. Advance online publication. doi: 10.1002/ejhf.1701
Yip, C., Seneviratna, A., Tan, S.-H., Khaing, T., Chan, S.-P., Loh, J., … Richards, A. M., & Chan, M. Y. (2020). Patients with acute and chronic coronary syndromes have elevated long-term thrombin generation. Journal of Thrombosis & Thrombolysis. Advance online publication. doi: 10.1007/s11239-020-02066-y
Woo, C. C., Liu, W., Lin, X. Y., Dorajoo, R., Lee, K. W., Richards, A. M., … Sorokin, V. (2020). The interaction between 30b-5p miRNA and MBNL1 mRNA is involved in vascular smooth muscle cell differentiation in patients with coronary atherosclerosis. International Journal of Molecular Sciences, 21, 11. doi: 10.3390/ijms21010011
MacDonald, M. R., Tay, W. T., Teng, T.-H. K., Anand, I., Ling, L. H., Yap, J., … ASIAN-HF investigators, Richards, A. M., & Lam, C. S. P. (2020). Regional variation of mortality in heart failure with reduced and preserved ejection fraction across Asia: Outcomes in the ASIAN-HF registry. Journal of the American Heart Association, 9(1), e012199. doi: 10.1161/jaha.119.012199
Pickering, J. W., Young, J. M., George, P. M., Pemberton, C. J., Watson, A., Aldous, S. J., … Troughton, R. W., Richards, A. M., … Than, M. P. (2020). Early kinetic profiles of troponin I and T measured by high-sensitivity assays in patients with myocardial infarction. Clinica Chimica Acta. Advance online publication. doi: 10.1016/j.cca.2020.02.009
Chapter in Book - Research
Pemberton, C. J., Charles, C. J., & Richards, A. M. (2017). Cardiac natriuretic peptides. In J. C. Schisler, C. H. Lang & M. S. Willis (Eds.), Endocrinology of the heart in health and disease. (pp. 3-39). Elsevier. doi: 10.1016/B978-0-12-803111-7.00001-4
Richards, M., & Rademaker, M. (2013). Urocortins. In A. Kastin (Ed.), Handbook of biologically active peptides. (2nd ed.) (pp. 1428-1436). San Diego, CA: Academic Press. doi: 10.1016/B978-0-12-385095-9.00194-9
Richards, A. M., Troughton, R. W., & Nicholls, M. G. (2011). Natriuretic peptides for guidance of acute and chronic heart failure therapy. In J. L. Januzzi (Ed.), Cardiac biomarkers in clinical practice. (pp. 559-580). Sudbury, MA: Jones & Bartlett.
Richards, A. M. (2009). What we may expect from biomarkers in heart failure. In E. Braunwald (Ed.), Biomarkers in heart failure: An issue of heart failure clinics (Vol.5-4). (pp. 463-470). Philadelphia, PA: Saunders. doi: 10.1016/j.hfc.2009.04.011
Troughton, R. W., & Richards, A. M. (2008). Natriuretic peptides for disease monitoring in patients with chronic heart failure. In J. A. de Lemos (Ed.), Biomarkers in heart disease. (pp. 140-160). Malden, MA: Blackwell.
Nicholls, M. G., & Richards, A. M. (2008). High-risk subgroups: Diabetes and hypertension. In A. Bayés-Genís & J. L. Januzzi (Eds.), NT-proBNP as a biomarker in cardiovascular diseses. (pp. 173-182). Thomson Reuters.
Troughton, R. W., & Richards, A. M. (2008). Outpatient monitoring and treatment of chronic heart failure guided by NT-proBNP measurement. In A. Bayés-Genís & J. L. Januzzi (Eds.), NT-proBNP as a biomarker in cardiovascular diseases. (pp. 91-100). Thomson Reuters.
Nicholls, M. G., & Richards, A. M. (2004). Looking at the adrenals as a primary source. In Handbook of Hypertension: Vol. 22. Hypertension in the Twentieth Century: Concepts and Achievements. (pp. 104-122). Amsterdam: Elsevier.
Lainchbury, J. G., & Richards, A. M. (2003). Exercise testing in the assessment of chronic congestive heart failure. In P. Mills (Ed.), Education in heart, volume 3. (pp. 56-64). London: BMJ Books.
Richards, M., & Nicholls, G. (2003). Endocrine causes of hypertension. In R. J. Johnson & J. Feehally (Eds.), Comprehensive clinical nephrology. (2nd ed.) (pp. 529-541). London, UK: Mosby.
Nicholls, M. G., Richards, A. M., & Yandle, T. G. (2002). The renin-angiotensin system. In G. Mancia, J. Chalmers, S. Julius, T. Saruta, M. Weber, A. Ferrari & I. Wilkinson (Eds.), Manual of Hypertension. (pp. 77-95). London: Churchill Livingstone.
Richards, A. M., Lainchbury, J. G., Nicholls, M. G., & Rademaker, M. T. (2000). Adrenomedullin in heart failure: Biochemical curiosity or pathophysiological player? In J. J. V. McMurray & J. G. F. Cleland (Eds.), Heart Failure in Clinical Practice. (2nd ed.) (pp. 105-125). London: Martin Dunitz.
Richards, A. M., Nicholls, M. G., & Troughton, R. W. (1999). The pharmacotherapy of diuretics. In N. Sharpe (Ed.), Heart Failure Management 2000. (pp. 43-60). London: Martin Dunitz.
Richards, A. M. (1999). Combined angiotensin convertin enzyme inhibition and angiotensin II type 1 receptor antagonism. In M. G. Nicholls, H. R. Brunner, H. Ikram, C. S. Sweet & J. F. Walker (Eds.), 100 Years of the Renin-Angiotensin System. (pp. 90-95). New Jersey, USA: Merck & Co..
Nicholls, M. G., Richards, A. M., & Begg, E. J. (1999). Hypertension as a cause of heart failure: Is it still important? In J. J. V. McMurray & J. G. F. Cleland (Eds.), Heart Failure in Clinical Practice. (pp. 19-32). London: Martin Dunitz.
Nicholls, M. G., Richards, A. M., & Begg, E. J. (1998). Hypertension as a cause of heart failure - is it still important? In J. J. V. McMurray & J. G. F. Cleland (Eds.), Heart Failure in Clinical Practice (Second Edition). London: Dunitz.
Espiner, E. A., Richards, A. M., & Nicholls, M. G. (1998). Physiology of natriuretic peptides. In E. R. Levin & J. Nadler (Eds.), Endocrinology of Cardiovascular Function. Kluwer Academic Publishers.
Nicholls, M. G., Richards, A. M., & Begg, E. J. (1997). Hypertension and heart failure. In A. Zanchetti & et al (Eds.), Hypertension and the heart. (pp. 273-279). New York: Plenum Press.
Lainchbury, J. G., Richards, A. M., & Nicholls, M. G. (1997). Brain natriuretic peptide in heart failure. In Atrial Natriuretic Peptides. (pp. 151-158).
Nicholls, M. G., Pidgeon, G. B., Lewis, L. K., & Richards, A. M. (1996). Ouabain, adrenal glands and hypertension. In G. P. Vinson & D. C. Anderson (Eds.), Adrenal Glands, Vascular System and Hypertension. (pp. 115-121). Bradley Stoke, Bristol, U.K.: Journal of Endocrinology Limited.
Chapter in Book - Other
Richards, M., Troughton, R., Espiner, E., Cameron, V., Ellmers, L., Pilbrow, A., Charles, C., Rademaker, M., Pemberton, C., & Yandle, T. (2013). Christchurch Heart Institute. In P. Joyce, G. Nicholls, K. Thomas & T. Wilkinson (Eds.), The Christchurch experience: 40 years of research and teaching. (pp. 68-74). Christchurch, New Zealand: University of Otago.
Nicholls, M. G., & Richards, A. M. (2007). Endocrine causes of hypertension. In J. Feehally, J. Floege & R. J. Johnson (Eds.), Comprehensive clinical nephrology. (3rd ed.) (pp. 443-452). Philadelphia: Mosby.
Richards, A. M., Nicholls, M. G., & Troughton, R. W. (2000). Diuretic therapy: Essential in heart failure. In N. Sharpe (Ed.), Heart failure management. (pp. 43-59). United Kingdom: Martin Dunitz.
Nicholls, M. G., Richards, A. M., & Begg, E. J. (2000). Hypertension as a cause of heart failure: Is it still important? In J. J. V. McMurray & J. G. F. Cleland (Eds.), Heart failure in clinical practice. (2nd ed.) (pp. 19-31). United Kingdom: Martin Dunitz.
Journal - Research Article
Aimo, A., Januzzi, Jr, J. L., Vergaro, G., Richards, A. M., Lam, C. S. P., Latini, R., … Troughton, R., … Edmin, M. (2020). Circulating levels and prognostic value of soluble ST2 in heart failure are less influenced by age than N-terminal pro-B-type natriuretic peptide and high-sensitivity troponin T. European Journal of Heart Failure. Advance online publication. doi: 10.1002/ejhf.1701
Pickering, J. W., Young, J. M., George, P. M., Pemberton, C. J., Watson, A., Aldous, S. J., … Troughton, R. W., Richards, A. M., … Than, M. P. (2020). Early kinetic profiles of troponin I and T measured by high-sensitivity assays in patients with myocardial infarction. Clinica Chimica Acta. Advance online publication. doi: 10.1016/j.cca.2020.02.009
MacDonald, M. R., Tay, W. T., Teng, T.-H. K., Anand, I., Ling, L. H., Yap, J., … ASIAN-HF investigators, Richards, A. M., & Lam, C. S. P. (2020). Regional variation of mortality in heart failure with reduced and preserved ejection fraction across Asia: Outcomes in the ASIAN-HF registry. Journal of the American Heart Association, 9(1), e012199. doi: 10.1161/jaha.119.012199
Woo, C. C., Liu, W., Lin, X. Y., Dorajoo, R., Lee, K. W., Richards, A. M., … Sorokin, V. (2020). The interaction between 30b-5p miRNA and MBNL1 mRNA is involved in vascular smooth muscle cell differentiation in patients with coronary atherosclerosis. International Journal of Molecular Sciences, 21, 11. doi: 10.3390/ijms21010011
Yip, C., Seneviratna, A., Tan, S.-H., Khaing, T., Chan, S.-P., Loh, J., … Richards, A. M., & Chan, M. Y. (2020). Patients with acute and chronic coronary syndromes have elevated long-term thrombin generation. Journal of Thrombosis & Thrombolysis. Advance online publication. doi: 10.1007/s11239-020-02066-y
Templeton, E. M., Cameron, V. A., Pickering, J. W., Richards, A. M., & Pilbrow, A. P. (2020). Emerging microRNA biomarkers for acute kidney injury in acute decompensated heart failure. Heart Failure Reviews. Advance online publication. doi: 10.1007/s10741-020-09928-w
Appleby, S., Chew-Harris, J., Troughton, R. W., Richards, A. M., & Pemberton, C. J. (2020). Analytical and biological assessment of circulating human erythroferrone. Clinical Biochemistry. Advance online publication. doi: 10.1016/j.clinbiochem.2020.02.001
Gallart-Palau, X., Tan, L. M., Serra, A., Gao, Y., Ho, H. H., Richards, A. M., … Sze, S. K. (2019). Degenerative protein modifications in the aging vasculature and central nervous system: A problem shared is not always halved. Ageing Research Reviews. Advance online publication. doi: 10.1016/j.arr.2019.100909
Lin, Z., Lim, S. H., Chua, S. J. T., Tai, E. S., Chan, Y. H., & Richards, A. M. (2019). High-sensitivity troponin T and long-term adverse cardiac events among patients presenting with suspected acute coronary syndrome in Singapore. Singapore Medical Journal. Advance online publication. doi: 10.11622/smedj.2019013
Wong, L. L., Saw, E. L., Lim, J. Y., Zhou, Y., Richards, A. M., & Wang, P. (2019). MicroRNA Let-7d-3p contributes to cardiac protection via targeting HMGA2. International Journal of Molecular Sciences, 20(7), 1522. doi: 10.3390/ijms20071522
Charles, C. J., Jardine, D. L., Rademaker, M. T., & Richards, A. M. (2019). Adrenomedullin 2 increases cardiac sympathetic nerve activity in parallel to heart rate in normal conscious sheep. Physiological Reports, 7(10), e14096. doi: 10.14814/phy2.14096
Stamp, L. K., Frampton, C., Drake, J., Doughty, R. N., Troughton, R. W., & Richards, A. M. (2019). Associations of gout and baseline serum urate with cardiovascular outcomes: Analysis of the Coronary Disease Cohort Study. Arthritis & Rheumatology. Advance online publication. doi: 10.1002/art.41007
Charles, C. J., Lee, P., Li, R. R., Yeung, T., Ibraham Mazlan, S. M., Tay, Z. W., … Richards, A. M. (2019). A porcine model of heart failure with preserved ejection fraction: Magnetic resonance imaging and metabolic energetics. ESC Heart Failure. Advance online publication. doi: 10.1002/ehf2.12536
Kuan, W. S., Ibrahim, I., Chan, S. P., Li, Z., Liew, O. W., Frampton, C., Troughton, R., Pemberton, C. J., … Richards, A. M. (2019). Mid-regional pro-adrenomedullin outperforms N-terminal pro-B-type natriuretic peptide for the diagnosis of acute heart failure in the presence of atrial fibrillation. European Journal of Heart Failure. Advance online publication. doi: 10.1002/ejhf.1660
Ong, C. W., Wee, I., Syn, N., Leo, H. L., Richards, A. M., & Choong, A. M. T. L. (2019). Computational fluid dynamics modelling of hemodynamic parameters in the human diseased aorta: A systematic review. Annals of Vascular Surgery. Advance online publication. doi: 10.1016/j.avsg.2019.04.032
Scott, N. J. A., Rademaker, M. T., Charles, C. J., Espiner, E. A., & Richards, A. M. (2019). Hemodynamic, hormonal, and renal actions of phosphodiesterase-9 inhibition in experimental heart failure. JACC, 74(7), 889-901. doi: 10.1016/j.jacc.2019.05.067
Tromp, J., Lim, S. L., Tay, W. T., Teng, T.-H. K., Chandramouli, C., Ouwerkerk, W., … Richards, A. M., … on behalf of the ASIAN-HF Investigators. (2019). Microvascular disease in patients with diabetes with heart failure and reduced ejection versus preserved ejection fraction. Diabetes Care. Advance online publication. doi: 10.2337/dc18-2515
Zhou, Y., Richards, A. M., & Wang, P. (2019). MicroRNA-221 is cardioprotective and anti-fibrotic in a rat model of myocardial infarction. Molecular Therapy: Nucleic Acids. Advance online publication. doi: 10.1016/j.omtn.2019.05.018
Chew-Harris, J., Appleby, S., Richards, A. M., Troughton, R. W., & Pemberton, C. J. (2019). Analytical, biochemical and clearance considerations of soluble urokinase plasminogen activator receptor (suPAR) in healthy individuals. Clinical Biochemistry. Advance online publication. doi: 10.1016/j.clinbiochem.2019.05.010
Patel, R. S., Schmidt, A. F., Tragante, V., McCubrey, R. O., Holmes, M. V., Howe, L. J., … Pilbrow, A. P., … Richards, A. M., … Cameron, V. A., … Asselbergs, F. W. (2019). Association of chromosome 9p21 with subsequent coronary heart disease events: A GENIUS-CHD study of individual participant data. Circulation: Genomic & Precision Medicine, 12(4), 161-172. doi: 10.1161/circgen.119.002471
Wong, L. L., Zou, R., Zhou, L., Lim, J. Y., Phua, D. C. Y., Liu, C., … Troughton, R., Cameron, V. A., … Richards, A. M. (2019). Combining circulating microRNA and NT-proBNP to detect and categorize heart failure subtypes. JACC, 73(11), 1300-1313. doi: 10.1016/j.jacc.2018.11.060
Tan, E. S. J., Tay, W. T., Teng, T.-H. K., Sim, D., Leong, K. T. G., Yeo, P. S. D., … Troughton, R. W., … Richards, A. M., … Lam, C. S. P. (2019). Ethnic differences in atrial fibrillation in patients with heart failure from Asia-Pacific. Heart. Advance online publication. doi: 10.1136/heartjnl-2018-314077
Poppe, K. K., Doughty, R. N., Wells, S., Wu, B., Earle, N. J., Richards, A. M., Troughton, R. W., … Kerr, A. J. (2019). Development and validation of a cardiovascular risk score for patients in the community after acute coronary syndrome. Heart. Advance online publication. doi: 10.1136/heartjnl-2019-315809
Mbikou, P., Rademaker, M. T., Charles, C. J., Richards, M. A., & Pemberton, C. J. (2019). Cardiovascular effects of DWORF (dwarf open reading frame) peptide in normal and ischaemia/reperfused isolated rat hearts. Peptides. Advance online publication. doi: 10.1016/j.peptides.2019.170192
Yap, J., Tay, W. T., Teng, T.-H. K., Anand, I., Richards, A. M., Ling, L. H., … Lam, C. S. P. (2019). Association of diabetes mellitus on cardiac remodeling, quality of life, and clinical outcomes in heart failure with reduced and preserved ejection fraction. Journal of the American Heart Association, 8(17), e013114. doi: 10.1161/JAHA.119.013114
Adamson, P. D., McAllister, D., Pilbrow, A., Pickering, J. W., Poppe, K., Shah, A., Whalley, G., … Pemberton, C., Troughton, R. W., … Richards, A. M. (2019). Convalescent troponin and cardiovascular death following acute coronary syndrome. Heart. Advance online publication. doi: 10.1136/heartjnl-2019-315084
