Professor A. Mark Richards, Our people, University of Otago, Christchurch, University of Otago, New Zealand

Professor

BA (Massey) MB ChB (Otago) MD(Otago,) PhD(Otago) DSc (Otago) FRACP FRCP FRSNZ

Department of Medicine
University of Otago, Christchurch
PO Box 4345
Christchurch
New Zealand

Mark Richards is the director of the Christchurch Heart Institute.

He coordinates and directs multi-disciplinary programmes of grant-funded translational cardiovascular research which seek to improve diagnostic, prognostic and therapeutic options in heart disease.

He is pursuing studies of epidemiological, molecular biological, neurohormonal and therapeutic aspects of acute and chronic cardiovascular disorders including hypertension, coronary syndromes, and the full spectrum of heart failure.

Richards holds the Heart Foundation of New Zealand’s Chair in Cardiovascular Studies.

He also holds joint appointments at the University of Otago and the National University of Singapore’s Cardiovascular Research Institute.
Email mdcarthu@nus.edu.sg (University of Singapore)

Current roles

Director, The Christchurch Heart Institute
Consultant Cardiologist, The Canterbury District Health Board

Research interests

Neurohormonal physiology and pathophysiology in cardiovascular health and disease
Heart Failure
Acute Coronary Syndromes
Hypertension
Vasoactive Hormones
The Cardiac Natriuretic Peptides

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Publications

Earle, N. J., Poppe, K. K., Rolleston, A., Pilbrow, A., Aish, S., Bradbury, K., … Troughton, R. W., … Richards, A. M., Cameron, V. A., … Doughty, R. N. (2023). Prognostic modelling of clinical outcomes after first-time acute coronary syndrome in New Zealand. Heart. Advance online publication. doi: 10.1136/heartjnl-2022-322010

Teng, T.-H. K., Tay, W. T., Ouwerkerk, W., Tromp, J., Richards, A. M., Gamble, G., … Troughton, R., … Doughty, R. N. (2023). Titration of medications and outcomes in multi-ethnic heart failure cohorts (with reduced ejection fraction) from Singapore and New Zealand. ESC Heart Failure. Advance online publication. doi: 10.1002/ehf2.14275

Vinaiphat, A., Pazhanchamy, K., JebaMercy, G., Ngan, S. C., Leow, M. K.-S., Ho, H. H., … Richards, A. M., … Sze, S. K. (2023). Endothelial damage arising from high salt hypertension Is elucidated by vascular bed systematic profiling. Arteriosclerosis, Thrombosis, & Vascular Biology. Advance online publication. doi: 10.1161/atvbaha.122.318439

Sazzad, F., Kuzemczak, M., Jason, C. Z., Tan, J. F., Ong, Z. X., Richards, A. M., & Kofidis, T. (2023). Transcatheter, targeted, myocardial restoration using hydrogel-based cell-free compound: Toward an adoptable clinical protocol. JTCVS Open. Advance online publication. doi: 10.1016/j.xjon.2022.12.008

Scott, N. J. A., Prickett, T. C. R., Charles, C. J., Frampton, C. M., Richards, A. M., & Rademaker, M. T. (2023). Augmentation of natriuretic peptide bioactivity via combined inhibition of neprilysin and phosphodiesterase-9 in heart failure. JACC: Heart Failure. Advance online publication. doi: 10.1016/j.jchf.2022.11.006

Pemberton, C. J., Charles, C. J., & Richards, A. M. (2017). Cardiac natriuretic peptides. In J. C. Schisler, C. H. Lang & M. S. Willis (Eds.), Endocrinology of the heart in health and disease. (pp. 3-39). Elsevier. doi: 10.1016/B978-0-12-803111-7.00001-4

Chapter in Book - Research

Richards, M., & Rademaker, M. (2013). Urocortins. In A. Kastin (Ed.), Handbook of biologically active peptides. (2nd ed.) (pp. 1428-1436). San Diego, CA: Academic Press. doi: 10.1016/B978-0-12-385095-9.00194-9

Chapter in Book - Research

Richards, A. M., Troughton, R. W., & Nicholls, M. G. (2011). Natriuretic peptides for guidance of acute and chronic heart failure therapy. In J. L. Januzzi (Ed.), Cardiac biomarkers in clinical practice. (pp. 559-580). Sudbury, MA: Jones & Bartlett.

Chapter in Book - Research

Richards, A. M. (2009). What we may expect from biomarkers in heart failure. In E. Braunwald (Ed.), Biomarkers in heart failure: An issue of heart failure clinics (Vol.5-4). (pp. 463-470). Philadelphia, PA: Saunders. doi: 10.1016/j.hfc.2009.04.011

Chapter in Book - Research

Nicholls, M. G., & Richards, A. M. (2008). High-risk subgroups: Diabetes and hypertension. In A. Bayés-Genís & J. L. Januzzi (Eds.), NT-proBNP as a biomarker in cardiovascular diseses. (pp. 173-182). Thomson Reuters.

Chapter in Book - Research

Troughton, R. W., & Richards, A. M. (2008). Natriuretic peptides for disease monitoring in patients with chronic heart failure. In J. A. de Lemos (Ed.), Biomarkers in heart disease. (pp. 140-160). Malden, MA: Blackwell.

Chapter in Book - Research

Troughton, R. W., & Richards, A. M. (2008). Outpatient monitoring and treatment of chronic heart failure guided by NT-proBNP measurement. In A. Bayés-Genís & J. L. Januzzi (Eds.), NT-proBNP as a biomarker in cardiovascular diseases. (pp. 91-100). Thomson Reuters.

Chapter in Book - Research

Nicholls, M. G., & Richards, A. M. (2004). Looking at the adrenals as a primary source. In Handbook of Hypertension: Vol. 22. Hypertension in the Twentieth Century: Concepts and Achievements. (pp. 104-122). Amsterdam: Elsevier.

Chapter in Book - Research

Lainchbury, J. G., & Richards, A. M. (2003). Exercise testing in the assessment of chronic congestive heart failure. In P. Mills (Ed.), Education in heart, volume 3. (pp. 56-64). London: BMJ Books.

Chapter in Book - Research

Richards, M., & Nicholls, G. (2003). Endocrine causes of hypertension. In R. J. Johnson & J. Feehally (Eds.), Comprehensive clinical nephrology. (2nd ed.) (pp. 529-541). London, UK: Mosby.

Chapter in Book - Research

Nicholls, M. G., Richards, A. M., & Yandle, T. G. (2002). The renin-angiotensin system. In G. Mancia, J. Chalmers, S. Julius, T. Saruta, M. Weber, A. Ferrari & I. Wilkinson (Eds.), Manual of Hypertension. (pp. 77-95). London: Churchill Livingstone.

Chapter in Book - Research

Richards, A. M., Lainchbury, J. G., Nicholls, M. G., & Rademaker, M. T. (2000). Adrenomedullin in heart failure: Biochemical curiosity or pathophysiological player? In J. J. V. McMurray & J. G. F. Cleland (Eds.), Heart Failure in Clinical Practice. (2nd ed.) (pp. 105-125). London: Martin Dunitz.

Chapter in Book - Research

Nicholls, M. G., Richards, A. M., & Begg, E. J. (1999). Hypertension as a cause of heart failure: Is it still important? In J. J. V. McMurray & J. G. F. Cleland (Eds.), Heart Failure in Clinical Practice. (pp. 19-32). London: Martin Dunitz.

Chapter in Book - Research

Richards, A. M. (1999). Combined angiotensin convertin enzyme inhibition and angiotensin II type 1 receptor antagonism. In M. G. Nicholls, H. R. Brunner, H. Ikram, C. S. Sweet & J. F. Walker (Eds.), 100 Years of the Renin-Angiotensin System. (pp. 90-95). New Jersey, USA: Merck & Co..

Chapter in Book - Research

Richards, A. M., Nicholls, M. G., & Troughton, R. W. (1999). The pharmacotherapy of diuretics. In N. Sharpe (Ed.), Heart Failure Management 2000. (pp. 43-60). London: Martin Dunitz.

Chapter in Book - Research

Espiner, E. A., Richards, A. M., & Nicholls, M. G. (1998). Physiology of natriuretic peptides. In E. R. Levin & J. Nadler (Eds.), Endocrinology of Cardiovascular Function. Kluwer Academic Publishers.

Chapter in Book - Research

Nicholls, M. G., Richards, A. M., & Begg, E. J. (1998). Hypertension as a cause of heart failure - is it still important? In J. J. V. McMurray & J. G. F. Cleland (Eds.), Heart Failure in Clinical Practice (Second Edition). London: Dunitz.

Chapter in Book - Research

Lainchbury, J. G., Richards, A. M., & Nicholls, M. G. (1997). Brain natriuretic peptide in heart failure. In Atrial Natriuretic Peptides. (pp. 151-158).

Chapter in Book - Research

Nicholls, M. G., Richards, A. M., & Begg, E. J. (1997). Hypertension and heart failure. In A. Zanchetti & et al (Eds.), Hypertension and the heart. (pp. 273-279). New York: Plenum Press.

Chapter in Book - Research

Nicholls, M. G., Pidgeon, G. B., Lewis, L. K., & Richards, A. M. (1996). Ouabain, adrenal glands and hypertension. In G. P. Vinson & D. C. Anderson (Eds.), Adrenal Glands, Vascular System and Hypertension. (pp. 115-121). Bradley Stoke, Bristol, U.K.: Journal of Endocrinology Limited.

Chapter in Book - Research

Richards, M., Troughton, R., Espiner, E., Cameron, V., Ellmers, L., Pilbrow, A., Charles, C., Rademaker, M., Pemberton, C., & Yandle, T. (2013). Christchurch Heart Institute. In P. Joyce, G. Nicholls, K. Thomas & T. Wilkinson (Eds.), The Christchurch experience: 40 years of research and teaching. (pp. 68-74). Christchurch, New Zealand: University of Otago.

Chapter in Book - Other

Nicholls, M. G., & Richards, A. M. (2007). Endocrine causes of hypertension. In J. Feehally, J. Floege & R. J. Johnson (Eds.), Comprehensive clinical nephrology. (3rd ed.) (pp. 443-452). Philadelphia: Mosby.

Chapter in Book - Other

Nicholls, M. G., Richards, A. M., & Begg, E. J. (2000). Hypertension as a cause of heart failure: Is it still important? In J. J. V. McMurray & J. G. F. Cleland (Eds.), Heart failure in clinical practice. (2nd ed.) (pp. 19-31). United Kingdom: Martin Dunitz.

Chapter in Book - Other

Richards, A. M., Nicholls, M. G., & Troughton, R. W. (2000). Diuretic therapy: Essential in heart failure. In N. Sharpe (Ed.), Heart failure management. (pp. 43-59). United Kingdom: Martin Dunitz.

Chapter in Book - Other

Journal - Research Article

Lim, X. C., Huang, C., Yatim, S. M. J. M., Chong, S. Y., Tan, S. H., Yang, X., … Richards, A. M., Charles, C. J., … Wang, J.-W. (2023). Temporal changes in extracellular vesicle hemostatic protein composition predict favourable left ventricular remodeling after acute myocardial infarction. International Journal of Molecular Sciences, 24, 327. doi: 10.3390/ijms24010327

Journal - Research Article

Tan, E. S. J., Jin, X., Oon, Y. Y., Chan, S. P., Gong, L., Lunaria, J. B., … Richards, A. M. (2023). Prognostic value of left atrial strain in aortic stenosis: A competing risk analysis. Journal of the American Society of Echocardiography, 36(1), 29-37. doi: 10.1016/j.echo.2022.10.011

Journal - Research Article

Teramoto, K., Tay, W. T., Tromp, J., Teng, T.-H. K., Chandramouli, C., Ouwerkerk, W., … Richards, A. M., & Lam, C. S. P. (2023). Patient-reported versus physician-assessed health status in heart failure with reduced and preserved ejection fraction from ASIAN-HF Registry. Circulation: Cardiovascular Quality & Outcomes, 16(1), e009134. doi: 10.1161/circoutcomes.122.009134

Journal - Research Article

Chin, Y., Lim, J., Kong, G., Ng, C. H., Goh, R., Muthiah, M., … Richards, A. M., … Chew, N. W. S. (2022). Hepatic steatosis and advanced hepatic fibrosis are independent predictors of long-term mortality in acute myocardial infarction. Diabetes, Obesity & Metabolism. Advance online publication. doi: 10.1111/dom.14950

Journal - Research Article

Fitzsimons, S., Poppe, K. K., Choi, Y., Devlin, G., Lund, M., Lam, C. S. P., Troughton, R., Richards, A. M., & Doughty, R. N. (2022). Relationship between soluble transferrin receptor and clinical outcomes in patients with heart failure according to ejection fraction phenotype: The New Zealand PEOPLE study. Journal of Cardiac Failure, 28(8), 1255-1263. doi: 10.1016/j.cardfail.2021.12.018

Journal - Research Article

Jin, X., Hung, C.-L., Tay, W. T., Soon, D., Sim, D., Sung, K. I., … Richards, A. M., … Lam, C. S. P. (2022). Epicardial adipose tissue related to left atrial and ventricular function in heart failure with preserved (HFpEF) versus reduced and mildly reduced ejection fraction (HFrEF/HFmrEF). European Journal of Heart Failure. Advance online publication. doi: 10.1002/ejhf.2513

Journal - Research Article

Koo, C. Y., Zheng, H., Tan, L. L., Foo, L.-L., Hausenloy, D. J., Chng, W.-J., … Richards, A. M., … Chan, M. Y. (2022). Prior cancer is associated with lower Atherosclerotic Cardiovascular Disease risk at first acute myocardial infarction. Biomedicines, 10, 2681. doi: 10.3390/biomedicines10112681

Journal - Research Article

Lee, K. K., Doudesis, D., Anwar, M., Astengo, A., Chenevier-Gobeaux, C., Claessens, Y.-E., … Pemberton, C., … Richards, A. M., … on behalf of the CoDE-HF investigators. (2022). Development and validation of a decision support tool for the diagnosis of acute heart failure: Systematic review, meta-analysis, and modelling study. BMJ, 377, e068424. doi: 10.1136/bmj-2021-068424

Journal - Research Article

Lewis, L. K., Raudsepp, S. D., Whitlow, J. C., Appleby, S., Pemberton, C. J., Yandle, T. G., & Richards, A. M. (2022). Assays specific for BNP1-32 and NT-proBNP exhibit a similar performance to two widely used assays in the diagnosis of heart failure. Clinical Chemistry. Advance online publication. doi: 10.1093/clinchem/hvac126

Journal - Research Article

Liew, O. W., Fanusi, F., Ng, J. Y. X., Ahidjo, B. A., Ling, S. S. M., Lilyanna, S., … Richards, A. M. (2022). Immunoassay-compatible inactivation of SARS-CoV-2 in plasma samples for enhanced handling safety. ACS Omega, 7(29), 25510-25520. doi: 10.1021/acsomega.2c02585

Journal - Research Article

Liew, O. W., Prickett, T. C. R., Revuelta-López, E., Ling, S. S. M., Cserkóová, A., Lupón, J., … Richards, A. M. (2022). Finding a reliable assay for soluble neprilysin. Clinical Biochemistry. Advance online publication. doi: 10.1016/j.clinbiochem.2022.03.004

Journal - Research Article

Manandhar, S., Scott-Thomas, A., Harrington, M., Sinha, P., Pilbrow, A., Richards, A. M., Cameron, V., Bhatia, M., & Chambers, S. T. (2022). Hydrogen sulfide and substance P levels in patients with Escherichia coli and Klebsiella pneumoniae bacteraemia. International Journal of Molecular Sciences, 23, 8639. doi: 10.3390/ijms23158639

Journal - Research Article

Robert, C., Ling, L.-H., Tan, E. S. J., Gyanwali, B., Venketasubramanian, N., Lim, S. L., … Richards, A. M., … Hilal, S. (2022). Effects of carotid artery stiffness on cerebral small-vessel disease and cognition. Journal of the American Heart Association, 11, e027295. doi: 10.1161/jaha.122.027295

Journal - Research Article

Schillemans, T., Tragante, V., Maitusong, B., Gigante, B., Cresci, S., Laguzzi, F., … Richards, M., Pilbrow, A., Cameron, V., … Leander, K. (2022). Associations of polymorphisms in the peroxisome proliferator-activated receptor gamma coactivator-1 alpha gene with subsequent coronary heart disease: An individual-level meta-analysis. Frontiers in Physiology, 13, 909870. doi: 10.3389/fphys.2022.909870

Journal - Research Article

Sia, C.-H., Tan, S.-H., Chan, S.-P., Marchesseau, S., Sim, H.-W., Carvalho, L., … Richards, A. M., … Chan, M. Y. (2022). Enhanced thrombin generation is associated with worse left ventricular scarring after ST-segment elevation myocardial infarction: A cohort study. Pharmaceuticals, 15, 718. doi: 10.3390/ph15060718

Journal - Research Article

Tan, E. S. J., Oon, Y. Y., Chan, S. P., Liew, O. W., Chong, J. P. C., Tay, E., … Richards, A. M., & Ling, L. H. (2022). Novel predictive role for mid-regional proadrenomedullin in moderate to severe aortic stenosis. Heart. Advance online publication. doi: 10.1136/heartjnl-2021-320707

Journal - Research Article

Tan, S. H., Koh, H. W. L., Chua, J. Y., Burla, B., Ong, C. C., Teo, L. S. L., … Richards, A. M., … Chan, M. Y. (2022). Variability of the plasma lipidome and subclinical coronary atherosclerosis. Arteriosclerosis, Thrombosis, & Vascular Biology, 42, 100-112. doi: 10.1161/ATVBAHA.121.316847

Journal - Research Article

Templeton, E. M., Lassé, M., Kleffmann, T., Ellmers, L. J., Palmer, S. C., Davidson, T., Scott, N. J. A., Pickering, J. W., Charles, C. J., Endre, Z. H., Cameron, V. A., Richards, A. M., Rademaker, M. T., & Pilbrow, A. P. (2022). Identifying candidate protein markers of acute kidney injury in acute decompensated heart failure. International Journal of Molecular Sciences, 23, 1009. doi: 10.3390/ijms23021009

Journal - Research Article

Tromp, J., Seekings, P. J., Hung, C.-L., Iversen, M. B., Frost, M. J., Ouwerkerk, W., … Richards, A. M., … Ezekowitz, J. A. (2022). Automated interpretation of systolic and diastolic function on the echocardiogram: A multicohort study. Lancet Digital Health, 4, e46-e54. doi: 10.1016/s2589-7500(21)00235-1

Journal - Research Article

Vergaro, G., Aimo, A., Januzzi, Jr, J. L., Richards, A. M., Lam, C. S. P., Latini, R., … Troughton, R., … Passino, C. (2022). Cardiac biomarkers retain prognostic significance in patients with heart failure and chronic obstructive pulmonary disease. Journal of Cardiovascular Medicine, 23(1), 28-36. doi: 10.2459/jcm.0000000000001281

Journal - Research Article

Vergaro, G., Gentile, F., Aimo, A., Januzzi, Jr, J. L., Richards, A. M., Lam, C. S. P., … Troughton, R., … Emdin, M. (2022). Circulating levels and prognostic cut-offs of sST2, hs-cTnT, and NT-proBNP in women vs. men with chronic heart failure. ESC Heart Failure. Advance online publication. doi: 10.1002/ehf2.13883

Journal - Research Article

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