Professor A. Mark Richards, Our people, University of Otago, Christchurch, University of Otago, New Zealand

Professor

BA (Massey) MB ChB (Otago) MD(Otago,) PhD(Otago) DSc (Otago) FRACP FRCP FRSNZ

Department of Medicine
University of Otago, Christchurch
PO Box 4345
Christchurch
New Zealand

Mark Richards is the director of the Christchurch Heart Institute.

He coordinates and directs multi-disciplinary programmes of grant-funded translational cardiovascular research which seek to improve diagnostic, prognostic and therapeutic options in heart disease.

He is pursuing studies of epidemiological, molecular biological, neurohormonal and therapeutic aspects of acute and chronic cardiovascular disorders including hypertension, coronary syndromes, and the full spectrum of heart failure.

Richards holds the Heart Foundation of New Zealand’s Chair in Cardiovascular Studies.

He also holds joint appointments at the University of Otago and the National University of Singapore’s Cardiovascular Research Institute.
Email mdcarthu@nus.edu.sg (University of Singapore)

Current roles

Director, The Christchurch Heart Institute
Consultant Cardiologist, The Canterbury District Health Board

Research interests

Neurohormonal physiology and pathophysiology in cardiovascular health and disease
Heart Failure
Acute Coronary Syndromes
Hypertension
Vasoactive Hormones
The Cardiac Natriuretic Peptides

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Publications

Rademaker, M. T., Pilbrow, A. P., Ellmers, L. J., Palmer, S. C., Davidson, T., Mbikou, P., Scott, N. J. A., Permina, E., Charles, C. J., Endre, Z. H., & Richards, A. M. (2021). Acute decompensated heart failure and the kidney: Physiological, histological and transcriptomic responses to development and recovery. Journal of the American Heart Association, 10, e021312. doi: 10.1161/jaha.121.021312

Moura, B., Aimo, A., Al-Mohammad, A., Flammer, A., Barberis, V., Bayes-Genis, A., … Richards, A. M. (2021). Integration of imaging and circulating biomarkers in heart failure: A consensus document by the Biomarkers and Imaging Study Groups of the Heart Failure Association of the European Society of Cardiology. European Journal of Heart Failure. Advance online publication. doi: 10.1002/ejhf.2339

Wang, P., Zhou, Y., & Richards, A. M. (2021). Effective tools for RNA-derived therapeutics: siRNA interference or miRNA mimicry. Theranostics, 11(18), 8771-8796. doi: 10.7150/thno.62642

Palmer, B. R., Paterson, M. A., Frampton, C. M., Pilbrow, A. P., Skelton, L., Pemberton, C. J., … Troughton, R. W., Richards, A. M., & Cameron, V. A. (2021). Vascular endothelial growth factor-A promoter polymorphisms, circulating VEGF-A and survival in acute coronary syndromes. PLoS ONE, 16(7), e0254206. doi: 10.1371/journal.pone.0254206

Legget, M. E., Cameron, V. A., Poppe, K. K., Aish, S., Earle, N., Choi, Y., … Troughton, R., Richards, A. M., … Doughty, R. N. (2021). The Multi-Ethnic New Zealand Study of Acute Coronary Syndromes (MENZACS): Design and methodology. Cardiogenetics, 11(2), 84-97. doi: 10.3390/cardiogenetics11020010

Pemberton, C. J., Charles, C. J., & Richards, A. M. (2017). Cardiac natriuretic peptides. In J. C. Schisler, C. H. Lang & M. S. Willis (Eds.), Endocrinology of the heart in health and disease. (pp. 3-39). Elsevier. doi: 10.1016/B978-0-12-803111-7.00001-4

Chapter in Book - Research

Richards, M., & Rademaker, M. (2013). Urocortins. In A. Kastin (Ed.), Handbook of biologically active peptides. (2nd ed.) (pp. 1428-1436). San Diego, CA: Academic Press. doi: 10.1016/B978-0-12-385095-9.00194-9

Chapter in Book - Research

Richards, A. M., Troughton, R. W., & Nicholls, M. G. (2011). Natriuretic peptides for guidance of acute and chronic heart failure therapy. In J. L. Januzzi (Ed.), Cardiac biomarkers in clinical practice. (pp. 559-580). Sudbury, MA: Jones & Bartlett.

Chapter in Book - Research

Richards, A. M. (2009). What we may expect from biomarkers in heart failure. In E. Braunwald (Ed.), Biomarkers in heart failure: An issue of heart failure clinics (Vol.5-4). (pp. 463-470). Philadelphia, PA: Saunders. doi: 10.1016/j.hfc.2009.04.011

Chapter in Book - Research

Nicholls, M. G., & Richards, A. M. (2008). High-risk subgroups: Diabetes and hypertension. In A. Bayés-Genís & J. L. Januzzi (Eds.), NT-proBNP as a biomarker in cardiovascular diseses. (pp. 173-182). Thomson Reuters.

Chapter in Book - Research

Troughton, R. W., & Richards, A. M. (2008). Natriuretic peptides for disease monitoring in patients with chronic heart failure. In J. A. de Lemos (Ed.), Biomarkers in heart disease. (pp. 140-160). Malden, MA: Blackwell.

Chapter in Book - Research

Troughton, R. W., & Richards, A. M. (2008). Outpatient monitoring and treatment of chronic heart failure guided by NT-proBNP measurement. In A. Bayés-Genís & J. L. Januzzi (Eds.), NT-proBNP as a biomarker in cardiovascular diseases. (pp. 91-100). Thomson Reuters.

Chapter in Book - Research

Nicholls, M. G., & Richards, A. M. (2004). Looking at the adrenals as a primary source. In Handbook of Hypertension: Vol. 22. Hypertension in the Twentieth Century: Concepts and Achievements. (pp. 104-122). Amsterdam: Elsevier.

Chapter in Book - Research

Lainchbury, J. G., & Richards, A. M. (2003). Exercise testing in the assessment of chronic congestive heart failure. In P. Mills (Ed.), Education in heart, volume 3. (pp. 56-64). London: BMJ Books.

Chapter in Book - Research

Richards, M., & Nicholls, G. (2003). Endocrine causes of hypertension. In R. J. Johnson & J. Feehally (Eds.), Comprehensive clinical nephrology. (2nd ed.) (pp. 529-541). London, UK: Mosby.

Chapter in Book - Research

Nicholls, M. G., Richards, A. M., & Yandle, T. G. (2002). The renin-angiotensin system. In G. Mancia, J. Chalmers, S. Julius, T. Saruta, M. Weber, A. Ferrari & I. Wilkinson (Eds.), Manual of Hypertension. (pp. 77-95). London: Churchill Livingstone.

Chapter in Book - Research

Richards, A. M., Lainchbury, J. G., Nicholls, M. G., & Rademaker, M. T. (2000). Adrenomedullin in heart failure: Biochemical curiosity or pathophysiological player? In J. J. V. McMurray & J. G. F. Cleland (Eds.), Heart Failure in Clinical Practice. (2nd ed.) (pp. 105-125). London: Martin Dunitz.

Chapter in Book - Research

Nicholls, M. G., Richards, A. M., & Begg, E. J. (1999). Hypertension as a cause of heart failure: Is it still important? In J. J. V. McMurray & J. G. F. Cleland (Eds.), Heart Failure in Clinical Practice. (pp. 19-32). London: Martin Dunitz.

Chapter in Book - Research

Richards, A. M. (1999). Combined angiotensin convertin enzyme inhibition and angiotensin II type 1 receptor antagonism. In M. G. Nicholls, H. R. Brunner, H. Ikram, C. S. Sweet & J. F. Walker (Eds.), 100 Years of the Renin-Angiotensin System. (pp. 90-95). New Jersey, USA: Merck & Co..

Chapter in Book - Research

Richards, A. M., Nicholls, M. G., & Troughton, R. W. (1999). The pharmacotherapy of diuretics. In N. Sharpe (Ed.), Heart Failure Management 2000. (pp. 43-60). London: Martin Dunitz.

Chapter in Book - Research

Espiner, E. A., Richards, A. M., & Nicholls, M. G. (1998). Physiology of natriuretic peptides. In E. R. Levin & J. Nadler (Eds.), Endocrinology of Cardiovascular Function. Kluwer Academic Publishers.

Chapter in Book - Research

Nicholls, M. G., Richards, A. M., & Begg, E. J. (1998). Hypertension as a cause of heart failure - is it still important? In J. J. V. McMurray & J. G. F. Cleland (Eds.), Heart Failure in Clinical Practice (Second Edition). London: Dunitz.

Chapter in Book - Research

Lainchbury, J. G., Richards, A. M., & Nicholls, M. G. (1997). Brain natriuretic peptide in heart failure. In Atrial Natriuretic Peptides. (pp. 151-158).

Chapter in Book - Research

Nicholls, M. G., Richards, A. M., & Begg, E. J. (1997). Hypertension and heart failure. In A. Zanchetti & et al (Eds.), Hypertension and the heart. (pp. 273-279). New York: Plenum Press.

Chapter in Book - Research

Nicholls, M. G., Pidgeon, G. B., Lewis, L. K., & Richards, A. M. (1996). Ouabain, adrenal glands and hypertension. In G. P. Vinson & D. C. Anderson (Eds.), Adrenal Glands, Vascular System and Hypertension. (pp. 115-121). Bradley Stoke, Bristol, U.K.: Journal of Endocrinology Limited.

Chapter in Book - Research

Richards, M., Troughton, R., Espiner, E., Cameron, V., Ellmers, L., Pilbrow, A., Charles, C., Rademaker, M., Pemberton, C., & Yandle, T. (2013). Christchurch Heart Institute. In P. Joyce, G. Nicholls, K. Thomas & T. Wilkinson (Eds.), The Christchurch experience: 40 years of research and teaching. (pp. 68-74). Christchurch, New Zealand: University of Otago.

Chapter in Book - Other

Nicholls, M. G., & Richards, A. M. (2007). Endocrine causes of hypertension. In J. Feehally, J. Floege & R. J. Johnson (Eds.), Comprehensive clinical nephrology. (3rd ed.) (pp. 443-452). Philadelphia: Mosby.

Chapter in Book - Other

Nicholls, M. G., Richards, A. M., & Begg, E. J. (2000). Hypertension as a cause of heart failure: Is it still important? In J. J. V. McMurray & J. G. F. Cleland (Eds.), Heart failure in clinical practice. (2nd ed.) (pp. 19-31). United Kingdom: Martin Dunitz.

Chapter in Book - Other

Richards, A. M., Nicholls, M. G., & Troughton, R. W. (2000). Diuretic therapy: Essential in heart failure. In N. Sharpe (Ed.), Heart failure management. (pp. 43-59). United Kingdom: Martin Dunitz.

Chapter in Book - Other

Fadil, H., Totman, J. J., Hausenloy, D. J., Ho, H.-H., Joseph, P., Low, A. F.-H., Richards, A. M., … Marchesseau, S. (2021). A deep learning pipeline for automatic analysis of multi-scan cardiovascular magnetic resonance. Journal of Cardiovascular Magnetic Resonance, 23, 47. doi: 10.1186/s12968-020-00695-z

Journal - Research Article

Lassé, M., Pilbrow, A. P., Kleffmann, T., Andersson Överström, E., von Zychlinski, A., Frampton, C. M. A., … Troughton, R. W., Lewis, L. K., Prickett, T. C. R., Pemberton, C. J., Richards, A. M., & Cameron, V. A. (2021). Fibrinogen and hemoglobin predict near future cardiovascular events in asymptomatic individuals. Scientific Reports, 11(1), 4605. doi: 10.1038/s41598-021-84046-7

Journal - Research Article

Liew, O. W., Ling, S. S. M., Lilyanna, S., Zhou, Y., Wang, P., Chong, J. P. C., … Richards, A. M. (2021). Epitope-directed monoclonal antibody production using a mixed antigen cocktail facilitates antibody characterization and validation. Communications Biology, 4, 441. doi: 10.1038/s42003-021-01965-x

Journal - Research Article

Lim, S. L., Liu, X., Gao, Q., Nyunt, S. Z., Gong, L., Lunaria, J. B., … Richards, A. M., … Ng, T. P. (2021). Subclinical vasculopathy and skeletal muscle metrics in the Singapore longitudinal ageing study. Aging, 13(11), 14768-14784. doi: 10.18632/aging.203142

Journal - Research Article

Lin, Z., Lim, S. H., Yap, Q. V., Tan, C. H. C., Chan, Y. H., Wong, H. C., … Richards, A. M., & Chua, T. S. J. (2021). Comparing conventional and high sensitivity troponin T measurements in identifying adverse cardiac events in patients admitted to an Asian emergency department chest pain observation unit. IJC Heart & Vasculature, 34, 100758. doi: 10.1016/j.ijcha.2021.100758

Journal - Research Article

Park, J. E., JebaMercy, G., Pazhanchamy, K., Guo, X., Ngan, S. C., Liou, K. C. K., … Richards, A. M., … Sze, S. K. (2021). Aging-induced isoDGR-modified fibronectin activates monocytic and endothelial cells to promote atherosclerosis. Atherosclerosis, 324, 58-68. doi: 10.1016/j.atherosclerosis.2021.03.020

Journal - Research Article

Rademaker, M. T., Scott, N. J. A., Koh, C. Y., Manjunatha Kini, R., & Richards, A. M. (2021). Natriuretic peptide analogues with distinct vasodilatory or renal activity: Integrated effects in health and experimental heart failure. Cardiovascular Research, 117, 508-519. doi: 10.1093/cvr/cvaa052

Journal - Research Article

Schunk, S. J., Kleber, M. E., März, W., Pang, S., Zewinger, S., Triem, S., … Pilbrow, A. P., Richards, A. M., Cameron, V. A., … BIOS consortium. (2021). Genetically determined NLRP3 inflammasome activation associates with systemic inflammation and cardiovascular mortality. European Heart Journal. Advance online publication. doi: 10.1093/eurheartj/ehab107

Journal - Research Article

Singh, S., de Ronde, M. W. J., Creemers, E. E., Van der Made, I., Meijering, R., Chan, M. Y., … Richards, A. M., Troughton, R. W., … Pinto-Sietsma, S. J. (2021). Low miR-19b-1-5p Expression is related to aspirin resistance and major adverse cardio- cerebrovascular events in patients with acute coronary syndrome. Journal of the American Heart Association, 10(2), e017120. doi: 10.1161/jaha.120.017120

Journal - Research Article

Templeton, E. M., Cameron, V. A., Pickering, J. W., Richards, A. M., & Pilbrow, A. P. (2021). Emerging microRNA biomarkers for acute kidney injury in acute decompensated heart failure. Heart Failure Reviews, 26, 1203-1217. doi: 10.1007/s10741-020-09928-w

Journal - Research Article

Teng, T.-H. K., Tay, W. T., Richards, A. M., Chew, T. S. M., Anand, I., Ouwerkerk, W., … on behalf of the ASIAN-HF investigators. (2021). Socioeconomic status and outcomes in heart failure with reduced ejection fraction from Asia. Circulation: Cardiovascular Quality & Outcomes, 14(4), e006962. doi: 10.1161/CIRCOUTCOMES.120.006962

Journal - Research Article

Tromp, J., Bryant, J. A., Jin, X., van Woerden, G., Asali, S., Yiying, H., … Richards, A. M., … Lam, C. S. P. (2021). Epicardial fat in heart failure with reduced versus preserved ejection fraction. European Journal of Heart Failure. Advance online publication. doi: 10.1002/ejhf.2156

Journal - Research Article

Vergaro, G., Gentile, F., Meems, L. M. G., Aimo, A., Januzzi, Jr, J. L., Richards, A. M., … Emdin, M. (2021). NT-proBNP for risk prediction in heart failure: Identification of optimal cutoffs across body mass index categories. JACC: Heart Failure. Advance online publication. doi: 10.1016/j.jchf.2021.05.014

Journal - Research Article

Aimo, A., Januzzi, Jr, J. L., Vergaro, G., Richards, A. M., Lam, C. S. P., Latini, R., … Troughton, R., … Edmin, M. (2020). Circulating levels and prognostic value of soluble ST2 in heart failure are less influenced by age than N-terminal pro-B-type natriuretic peptide and high-sensitivity troponin T. European Journal of Heart Failure, 22, 2078-2088. doi: 10.1002/ejhf.1701

Journal - Research Article

Appleby, S., Chew-Harris, J., Troughton, R. W., Richards, A. M., & Pemberton, C. J. (2020). Analytical and biological assessment of circulating human erythroferrone. Clinical Biochemistry, 79, 41-47. doi: 10.1016/j.clinbiochem.2020.02.001

Journal - Research Article

Chan, M. Y., Efthymios, M., Tan, S. H., Pickering, J. W., Troughton, R., Pemberton, C., … Pilbrow, A., & Richards, A. M. (2020). Prioritizing candidates of post-myocardial infarction heart failure using plasma proteomics and single-cell transcriptomics. Circulation, 142, 1408-1421. doi: 10.1161/circulationaha.119.045158

Journal - Research Article

Chan, M. Y., Koh, K. W. L., Poh, S.-C., Marchesseau, S., Singh, D., Han, Y., … for the IMMACULATE Investigators, including Richards, A. M. (2020). Remote postdischarge treatment of patients with acute myocardial infarction by allied health care practitioners vs standard care: The IMMACULATE randomized clinical trial. JAMA Cardiology. Advance online publication. doi: 10.1001/jamacardio.2020.6721

Journal - Research Article

Charles, C. J., Lee, P., Li, R. R., Yeung, T., Ibraham Mazlan, S. M., Tay, Z. W., … Richards, A. M. (2020). A porcine model of heart failure with preserved ejection fraction: Magnetic resonance imaging and metabolic energetics. ESC Heart Failure, 7, 93-103. doi: 10.1002/ehf2.12536

Journal - Research Article

Charles, C. J., Li, R. R., Yeung, T., Mazlan, S. M. I., Lai, R. C., de Kleijn, D. P. V., … Richards, A. M. (2020). Systemic mesenchymal stem cell-derived exosomes reduce myocardial infarct size: Characterization with MRI in a porcine model. Frontiers in Cardiovascular Medicine, 7, 601990. doi: 10.3389/fcvm.2020.601990

Journal - Research Article

Ellmers, L. J., Templeton, E. M., Pilbrow, A. P., Frampton, C., Ishii, I., Moore, P. K., Bhatia, M., Richards, A. M., & Cameron, V. A. (2020). Hydrogen sulfide treatment improves post-infarct remodeling and long-term cardiac function in CSE knockout and wild-type mice. International Journal of Molecular Sciences, 21(12), 4284. doi: 10.3390/ijms21124284

Journal - Research Article

Huang, W., Teng, T.-H. K., Tay, W. T., Richards, A. M., Kadam, U., Lawson, C. A., … Lam, C. S. P. (2020). Patient-reported outcomes in heart failure with preserved vs. reduced ejection fraction: Focus on physical independence. ESC Heart Failure, 7, 2051-2062. doi: 10.1002/ehf2.12950

Journal - Research Article

Kuan, W. S., Ibrahim, I., Chan, S. P., Li, Z., Liew, O. W., Frampton, C., Troughton, R., Pemberton, C. J., … Richards, A. M. (2020). Mid-regional pro-adrenomedullin outperforms N-terminal pro-B-type natriuretic peptide for the diagnosis of acute heart failure in the presence of atrial fibrillation. European Journal of Heart Failure, 22, 692-700. doi: 10.1002/ejhf.1660

Journal - Research Article

Lim, S. L., Gandhi, M., Woo, K. L., Chua, H. R., Lim, Y. C., Sim, D. K. L., … Richards, A. M., & Lam, C. S. P. (2020). Nitrates in combination with hydralazine in cardiorenal syndrome: A randomized controlled proof-of-concept study. ESC Heart Failure. Advance online publication. doi: 10.1002/ehf2.13076

Journal - Research Article

MacDonald, M. R., Tay, W. T., Teng, T.-H. K., Anand, I., Ling, L. H., Yap, J., … ASIAN-HF investigators, Richards, A. M., & Lam, C. S. P. (2020). Regional variation of mortality in heart failure with reduced and preserved ejection fraction across Asia: Outcomes in the ASIAN-HF registry. Journal of the American Heart Association, 9(1), e012199. doi: 10.1161/jaha.119.012199

Journal - Research Article

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