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Professor A. Mark Richards

Mark RichardsProfessor

BA (Massey) MB ChB (Otago) MD(Otago,) PhD(Otago) DSc (Otago) FRACP FRCP FRSNZ 

Department of Medicine
University of Otago, Christchurch
PO Box 4345
Christchurch
New Zealand

Email mark.richards@cdhb.health.nz

Mark Richards is the director of the Christchurch Heart Institute.

He coordinates and directs multi-disciplinary programmes of grant-funded translational cardiovascular research which seek to improve diagnostic, prognostic and therapeutic options in heart disease.

He is pursuing studies of epidemiological, molecular biological, neurohormonal and therapeutic aspects of acute and chronic cardiovascular disorders including hypertension, coronary syndromes, and the full spectrum of heart failure.

Richards holds the Heart Foundation of New Zealand’s Chair in Cardiovascular Studies.

He also holds joint appointments at the University of Otago and the National University of Singapore’s Cardiovascular Research Institute.
Email mdcarthu@nus.edu.sg (University of Singapore)

Current roles

Research interests

  • Neurohormonal physiology and pathophysiology in cardiovascular health and disease
  • Heart Failure
  • Acute Coronary Syndromes
  • Hypertension
  • Vasoactive Hormones
  • The Cardiac Natriuretic Peptides

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Publications

Sia, C.-H., Tan, S.-H., Chan, S.-P., Marchesseau, S., Sim, H.-W., Carvalho, L., … Richards, A. M., … Chan, M. Y. (2022). Enhanced thrombin generation is associated with worse left ventricular scarring after ST-segment elevation myocardial infarction: A cohort study. Pharmaceuticals, 15, 718. doi: 10.3390/ph15060718

Zheng, Y., Chan, W. X., Charles, C. J., Richards, A. M., Sampath, S., Ali, A. A. B., … Yap, C. H. (2022). Effects of hypertrophic and dilated cardiac geometric remodeling on ejection fraction. Frontiers in Physiology, 13, 898775. doi: 10.3389/fphys.2022.898775

Lee, K. K., Doudesis, D., Anwar, M., Astengo, A., Chenevier-Gobeaux, C., Claessens, Y.-E., … Pemberton, C., … Richards, A. M., … on behalf of the CoDE-HF investigators. (2022). Development and validation of a decision support tool for the diagnosis of acute heart failure: Systematic review, meta-analysis, and modelling study. BMJ, 377, e068424. doi: 10.1136/bmj-2021-068424

Vergaro, G., Gentile, F., Aimo, A., Januzzi, Jr, J. L., Richards, A. M., Lam, C. S. P., … Troughton, R., … Emdin, M. (2022). Circulating levels and prognostic cut-offs of sST2, hs-cTnT, and NT-proBNP in women vs. men with chronic heart failure. ESC Heart Failure. Advance online publication. doi: 10.1002/ehf2.13883

Jin, X., Hung, C.-L., Tay, W. T., Soon, D., Sim, D., Sung, K. I., … Richards, A. M., … Lam, C. S. P. (2022). Epicardial adipose tissue related to left atrial and ventricular function in heart failure with preserved (HFpEF) versus reduced and mildly reduced ejection fraction (HFrEF/HFmrEF). European Journal of Heart Failure. Advance online publication. doi: 10.1002/ejhf.2513

Pemberton, C. J., Charles, C. J., & Richards, A. M. (2017). Cardiac natriuretic peptides. In J. C. Schisler, C. H. Lang & M. S. Willis (Eds.), Endocrinology of the heart in health and disease. (pp. 3-39). Elsevier. doi: 10.1016/B978-0-12-803111-7.00001-4

Chapter in Book - Research

Richards, M., & Rademaker, M. (2013). Urocortins. In A. Kastin (Ed.), Handbook of biologically active peptides. (2nd ed.) (pp. 1428-1436). San Diego, CA: Academic Press. doi: 10.1016/B978-0-12-385095-9.00194-9

Chapter in Book - Research

Richards, A. M., Troughton, R. W., & Nicholls, M. G. (2011). Natriuretic peptides for guidance of acute and chronic heart failure therapy. In J. L. Januzzi (Ed.), Cardiac biomarkers in clinical practice. (pp. 559-580). Sudbury, MA: Jones & Bartlett.

Chapter in Book - Research

Richards, A. M. (2009). What we may expect from biomarkers in heart failure. In E. Braunwald (Ed.), Biomarkers in heart failure: An issue of heart failure clinics (Vol.5-4). (pp. 463-470). Philadelphia, PA: Saunders. doi: 10.1016/j.hfc.2009.04.011

Chapter in Book - Research

Nicholls, M. G., & Richards, A. M. (2008). High-risk subgroups: Diabetes and hypertension. In A. Bayés-Genís & J. L. Januzzi (Eds.), NT-proBNP as a biomarker in cardiovascular diseses. (pp. 173-182). Thomson Reuters.

Chapter in Book - Research

Troughton, R. W., & Richards, A. M. (2008). Natriuretic peptides for disease monitoring in patients with chronic heart failure. In J. A. de Lemos (Ed.), Biomarkers in heart disease. (pp. 140-160). Malden, MA: Blackwell.

Chapter in Book - Research

Troughton, R. W., & Richards, A. M. (2008). Outpatient monitoring and treatment of chronic heart failure guided by NT-proBNP measurement. In A. Bayés-Genís & J. L. Januzzi (Eds.), NT-proBNP as a biomarker in cardiovascular diseases. (pp. 91-100). Thomson Reuters.

Chapter in Book - Research

Nicholls, M. G., & Richards, A. M. (2004). Looking at the adrenals as a primary source. In Handbook of Hypertension: Vol. 22. Hypertension in the Twentieth Century: Concepts and Achievements. (pp. 104-122). Amsterdam: Elsevier.

Chapter in Book - Research

Lainchbury, J. G., & Richards, A. M. (2003). Exercise testing in the assessment of chronic congestive heart failure. In P. Mills (Ed.), Education in heart, volume 3. (pp. 56-64). London: BMJ Books.

Chapter in Book - Research

Richards, M., & Nicholls, G. (2003). Endocrine causes of hypertension. In R. J. Johnson & J. Feehally (Eds.), Comprehensive clinical nephrology. (2nd ed.) (pp. 529-541). London, UK: Mosby.

Chapter in Book - Research

Nicholls, M. G., Richards, A. M., & Yandle, T. G. (2002). The renin-angiotensin system. In G. Mancia, J. Chalmers, S. Julius, T. Saruta, M. Weber, A. Ferrari & I. Wilkinson (Eds.), Manual of Hypertension. (pp. 77-95). London: Churchill Livingstone.

Chapter in Book - Research

Richards, A. M., Lainchbury, J. G., Nicholls, M. G., & Rademaker, M. T. (2000). Adrenomedullin in heart failure: Biochemical curiosity or pathophysiological player? In J. J. V. McMurray & J. G. F. Cleland (Eds.), Heart Failure in Clinical Practice. (2nd ed.) (pp. 105-125). London: Martin Dunitz.

Chapter in Book - Research

Nicholls, M. G., Richards, A. M., & Begg, E. J. (1999). Hypertension as a cause of heart failure: Is it still important? In J. J. V. McMurray & J. G. F. Cleland (Eds.), Heart Failure in Clinical Practice. (pp. 19-32). London: Martin Dunitz.

Chapter in Book - Research

Richards, A. M. (1999). Combined angiotensin convertin enzyme inhibition and angiotensin II type 1 receptor antagonism. In M. G. Nicholls, H. R. Brunner, H. Ikram, C. S. Sweet & J. F. Walker (Eds.), 100 Years of the Renin-Angiotensin System. (pp. 90-95). New Jersey, USA: Merck & Co..

Chapter in Book - Research

Richards, A. M., Nicholls, M. G., & Troughton, R. W. (1999). The pharmacotherapy of diuretics. In N. Sharpe (Ed.), Heart Failure Management 2000. (pp. 43-60). London: Martin Dunitz.

Chapter in Book - Research

Espiner, E. A., Richards, A. M., & Nicholls, M. G. (1998). Physiology of natriuretic peptides. In E. R. Levin & J. Nadler (Eds.), Endocrinology of Cardiovascular Function. Kluwer Academic Publishers.

Chapter in Book - Research

Nicholls, M. G., Richards, A. M., & Begg, E. J. (1998). Hypertension as a cause of heart failure - is it still important? In J. J. V. McMurray & J. G. F. Cleland (Eds.), Heart Failure in Clinical Practice (Second Edition). London: Dunitz.

Chapter in Book - Research

Lainchbury, J. G., Richards, A. M., & Nicholls, M. G. (1997). Brain natriuretic peptide in heart failure. In Atrial Natriuretic Peptides. (pp. 151-158).

Chapter in Book - Research

Nicholls, M. G., Richards, A. M., & Begg, E. J. (1997). Hypertension and heart failure. In A. Zanchetti & et al (Eds.), Hypertension and the heart. (pp. 273-279). New York: Plenum Press.

Chapter in Book - Research

Nicholls, M. G., Pidgeon, G. B., Lewis, L. K., & Richards, A. M. (1996). Ouabain, adrenal glands and hypertension. In G. P. Vinson & D. C. Anderson (Eds.), Adrenal Glands, Vascular System and Hypertension. (pp. 115-121). Bradley Stoke, Bristol, U.K.: Journal of Endocrinology Limited.

Chapter in Book - Research

Richards, M., Troughton, R., Espiner, E., Cameron, V., Ellmers, L., Pilbrow, A., Charles, C., Rademaker, M., Pemberton, C., & Yandle, T. (2013). Christchurch Heart Institute. In P. Joyce, G. Nicholls, K. Thomas & T. Wilkinson (Eds.), The Christchurch experience: 40 years of research and teaching. (pp. 68-74). Christchurch, New Zealand: University of Otago.

Chapter in Book - Other

Nicholls, M. G., & Richards, A. M. (2007). Endocrine causes of hypertension. In J. Feehally, J. Floege & R. J. Johnson (Eds.), Comprehensive clinical nephrology. (3rd ed.) (pp. 443-452). Philadelphia: Mosby.

Chapter in Book - Other

Nicholls, M. G., Richards, A. M., & Begg, E. J. (2000). Hypertension as a cause of heart failure: Is it still important? In J. J. V. McMurray & J. G. F. Cleland (Eds.), Heart failure in clinical practice. (2nd ed.) (pp. 19-31). United Kingdom: Martin Dunitz.

Chapter in Book - Other

Richards, A. M., Nicholls, M. G., & Troughton, R. W. (2000). Diuretic therapy: Essential in heart failure. In N. Sharpe (Ed.), Heart failure management. (pp. 43-59). United Kingdom: Martin Dunitz.

Chapter in Book - Other

Fitzsimons, S., Poppe, K. K., Choi, Y., Devlin, G., Lund, M., Lam, C. S. P., … Richards, A. M., & Doughty, R. N. (2022). Relationship between soluble transferrin receptor and clinical outcomes in patients with Heart Failure According to Ejection Fraction Phenotype: The New Zealand PEOPLE Study. Journal of Cardiac Failure. Advance online publication. doi: 10.1016/j.cardfail.2021.12.018

Journal - Research Article

Jin, X., Hung, C.-L., Tay, W. T., Soon, D., Sim, D., Sung, K. I., … Richards, A. M., … Lam, C. S. P. (2022). Epicardial adipose tissue related to left atrial and ventricular function in heart failure with preserved (HFpEF) versus reduced and mildly reduced ejection fraction (HFrEF/HFmrEF). European Journal of Heart Failure. Advance online publication. doi: 10.1002/ejhf.2513

Journal - Research Article

Lee, K. K., Doudesis, D., Anwar, M., Astengo, A., Chenevier-Gobeaux, C., Claessens, Y.-E., … Pemberton, C., … Richards, A. M., … on behalf of the CoDE-HF investigators. (2022). Development and validation of a decision support tool for the diagnosis of acute heart failure: Systematic review, meta-analysis, and modelling study. BMJ, 377, e068424. doi: 10.1136/bmj-2021-068424

Journal - Research Article

Liew, O. W., Prickett, T. C. R., Revuelta-López, E., Ling, S. S. M., Cserkóová, A., Lupón, J., … Richards, A. M. (2022). Finding a reliable assay for soluble neprilysin. Clinical Biochemistry. Advance online publication. doi: 10.1016/j.clinbiochem.2022.03.004

Journal - Research Article

Sia, C.-H., Tan, S.-H., Chan, S.-P., Marchesseau, S., Sim, H.-W., Carvalho, L., … Richards, A. M., … Chan, M. Y. (2022). Enhanced thrombin generation is associated with worse left ventricular scarring after ST-segment elevation myocardial infarction: A cohort study. Pharmaceuticals, 15, 718. doi: 10.3390/ph15060718

Journal - Research Article

Tan, E. S. J., Oon, Y. Y., Chan, S. P., Liew, O. W., Chong, J. P. C., Tay, E., … Richards, A. M., & Ling, L. H. (2022). Novel predictive role for mid-regional proadrenomedullin in moderate to severe aortic stenosis. Heart. Advance online publication. doi: 10.1136/heartjnl-2021-320707

Journal - Research Article

Tan, S. H., Koh, H. W. L., Chua, J. Y., Burla, B., Ong, C. C., Teo, L. S. L., … Richards, A. M., … Chan, M. Y. (2022). Variability of the plasma lipidome and subclinical coronary atherosclerosis. Arteriosclerosis, Thrombosis, & Vascular Biology, 42, 100-112. doi: 10.1161/ATVBAHA.121.316847

Journal - Research Article

Templeton, E. M., Lassé, M., Kleffmann, T., Ellmers, L. J., Palmer, S. C., Davidson, T., Scott, N. J. A., Pickering, J. W., Charles, C. J., Endre, Z. H., Cameron, V. A., Richards, A. M., Rademaker, M. T., & Pilbrow, A. P. (2022). Identifying candidate protein markers of acute kidney injury in acute decompensated heart failure. International Journal of Molecular Sciences, 23, 1009. doi: 10.3390/ijms23021009

Journal - Research Article

Vergaro, G., Aimo, A., Januzzi, Jr, J. L., Richards, A. M., Lam, C. S. P., Latini, R., … Troughton, R., … Passino, C. (2022). Cardiac biomarkers retain prognostic significance in patients with heart failure and chronic obstructive pulmonary disease. Journal of Cardiovascular Medicine, 23(1), 28-36. doi: 10.2459/jcm.0000000000001281

Journal - Research Article

Vergaro, G., Gentile, F., Aimo, A., Januzzi, Jr, J. L., Richards, A. M., Lam, C. S. P., … Troughton, R., … Emdin, M. (2022). Circulating levels and prognostic cut-offs of sST2, hs-cTnT, and NT-proBNP in women vs. men with chronic heart failure. ESC Heart Failure. Advance online publication. doi: 10.1002/ehf2.13883

Journal - Research Article

Wu, Z., Sluyter, J., Liew, O. W., Chong, J. P. C., Med, D. W., Camargo, Jr, C. A., Richards, A. M., & Scragg, R. (2022). Effect of monthly vitamin D supplementation on cardiac biomarkers: A post-hoc analysis of a randomized controlled trial. Journal of Steroid Biochemistry & Molecular Biology. Advance online publication. doi: 10.1016/j.jsbmb.2022.106093

Journal - Research Article

Zheng, Y., Chan, W. X., Charles, C. J., Richards, A. M., Sampath, S., Ali, A. A. B., … Yap, C. H. (2022). Effects of hypertrophic and dilated cardiac geometric remodeling on ejection fraction. Frontiers in Physiology, 13, 898775. doi: 10.3389/fphys.2022.898775

Journal - Research Article

Aung, T., Qin, Y., Tay, W. T., Bamadhaj, N. S. B. S., Chandramouli, C., Ouwerkerk, W., … Richards, A. M., … Lam, C. S. P. (2021). Prevalence and prognostic significance of frailty in Asian patients with heart failure: Insights from ASIAN-HF. JACC: Asia, 1(3), 303-313. doi: 10.1016/j.jacasi.2021.09.006

Journal - Research Article

Fadil, H., Totman, J. J., Hausenloy, D. J., Ho, H.-H., Joseph, P., Low, A. F.-H., Richards, A. M., … Marchesseau, S. (2021). A deep learning pipeline for automatic analysis of multi-scan cardiovascular magnetic resonance. Journal of Cardiovascular Magnetic Resonance, 23, 47. doi: 10.1186/s12968-020-00695-z

Journal - Research Article

Fitzsimons, S., Yeo, T. J., Ling, L. H., Sim, D., Leong, K. T. G., Yeo, P. S. D., … Troughton, R., … Richards, A. M., & Doughty, R. N. (2021). Impact of change in iron status over time on clinical outcomes in heart failure according to ejection fraction phenotype. ESC Heart Failure. Advance online publication. doi: 10.1002/ehf2.13617

Journal - Research Article

Koh, C. Y., Shih, N., Yip, C. Y. C., Li, A. W. L., Chen, W., Amran, F. S., … Richards, A. M., … Chan, M. Y. (2021). Efficacy and safety of next-generation tick transcriptome-derived direct thrombin inhibitors. Nature Communications, 12, 6912. doi: 10.1038/s41467-021-27275-8

Journal - Research Article

Koo, C. Y., Zheng, H., Tan, L. L., Foo, L. L., Seet, R., Chong, J.-H., … Richards, A. M., … Chan, M. Y. (2021). Lipid profiles and outcomes of patients with prior cancer and subsequent myocardial infarction or stroke. Scientific Reports, 11, 21167. doi: 10.1038/s41598-021-00666-z

Journal - Research Article

Lassé, M., Pilbrow, A. P., Kleffmann, T., Andersson Överström, E., von Zychlinski, A., Frampton, C. M. A., … Troughton, R. W., Lewis, L. K., Prickett, T. C. R., Pemberton, C. J., Richards, A. M., & Cameron, V. A. (2021). Fibrinogen and hemoglobin predict near future cardiovascular events in asymptomatic individuals. Scientific Reports, 11(1), 4605. doi: 10.1038/s41598-021-84046-7

Journal - Research Article

Liew, O. W., Ling, S. S. M., Lilyanna, S., Zhou, Y., Wang, P., Chong, J. P. C., … Richards, A. M. (2021). Epitope-directed monoclonal antibody production using a mixed antigen cocktail facilitates antibody characterization and validation. Communications Biology, 4, 441. doi: 10.1038/s42003-021-01965-x

Journal - Research Article

Lim, S. L., Liu, X., Gao, Q., Nyunt, S. Z., Gong, L., Lunaria, J. B., … Richards, A. M., … Ng, T. P. (2021). Subclinical vasculopathy and skeletal muscle metrics in the Singapore longitudinal ageing study. Aging, 13(11), 14768-14784. doi: 10.18632/aging.203142

Journal - Research Article

Lin, Z., Lim, S. H., Yap, Q. V., Tan, C. H. C., Chan, Y. H., Wong, H. C., … Richards, A. M., & Chua, T. S. J. (2021). Comparing conventional and high sensitivity troponin T measurements in identifying adverse cardiac events in patients admitted to an Asian emergency department chest pain observation unit. IJC Heart & Vasculature, 34, 100758. doi: 10.1016/j.ijcha.2021.100758

Journal - Research Article

Palmer, B. R., Paterson, M. A., Frampton, C. M., Pilbrow, A. P., Skelton, L., Pemberton, C. J., … Troughton, R. W., Richards, A. M., & Cameron, V. A. (2021). Vascular endothelial growth factor-A promoter polymorphisms, circulating VEGF-A and survival in acute coronary syndromes. PLoS ONE, 16(7), e0254206. doi: 10.1371/journal.pone.0254206

Journal - Research Article

Park, J. E., JebaMercy, G., Pazhanchamy, K., Guo, X., Ngan, S. C., Liou, K. C. K., … Richards, A. M., … Sze, S. K. (2021). Aging-induced isoDGR-modified fibronectin activates monocytic and endothelial cells to promote atherosclerosis. Atherosclerosis, 324, 58-68. doi: 10.1016/j.atherosclerosis.2021.03.020

Journal - Research Article

Poh, K. K., Shabbir, A., Ngiam, J. N., Lee, P. S. S., So, J., Frampton, C. M., Pemberton, C. J., & Richards, A. M. (2021). Plasma clearance of B-type natriuretic peptide (BNP) before and after bariatric durgery for morbid obesity. Clinical Chemistry, 67(4), 662-671. doi: 10.1093/clinchem/hvaa308

Journal - Research Article

Rademaker, M. T., Pilbrow, A. P., Ellmers, L. J., Palmer, S. C., Davidson, T., Mbikou, P., Scott, N. J. A., Permina, E., Charles, C. J., Endre, Z. H., & Richards, A. M. (2021). Acute decompensated heart failure and the kidney: Physiological, histological and transcriptomic responses to development and recovery. Journal of the American Heart Association, 10, e021312. doi: 10.1161/jaha.121.021312

Journal - Research Article

Rademaker, M. T., Scott, N. J. A., Koh, C. Y., Manjunatha Kini, R., & Richards, A. M. (2021). Natriuretic peptide analogues with distinct vasodilatory or renal activity: Integrated effects in health and experimental heart failure. Cardiovascular Research, 117, 508-519. doi: 10.1093/cvr/cvaa052

Journal - Research Article

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