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Professor Richard W. Troughton

Richard Troughton

MB ChB(Auck) PhD(Otago) FRACP

Email richard.troughton@cdhb.health.nz

Department of Medicine
University of Otago, Christchurch
PO Box 4345
Christchurch
New Zealand

Current roles

  • Professor in Medicine
  • Cardiologist

Research interests

  • Neurohormonal control of cardiovascular and renal function
  • Heart Failure
  • Echocardiography
  • Left Ventricular Diastolic Function
  • Novel monitoring devices for heart failure

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Publications

Prickett, T. C. R., Spittlehouse, J. K., Miller, A. L., Liau, Y., Kennedy, M. A., Cameron, V. A., Pearson, J. F., Boden, J. M., Troughton, R. W., & Espiner, E. A. (2019). Contrasting signals of cardiovascular health among natriuretic peptides in subjects without heart disease. Scientific Reports, 9, 12108. doi: 10.1038/s41598-019-48553-y

Chew-Harris, J., Appleby, S., Richards, A. M., Troughton, R. W., & Pemberton, C. J. (2019). Analytical, biochemical and clearance considerations of soluble urokinase plasminogen activator receptor (suPAR) in healthy individuals. Clinical Biochemistry. Advance online publication. doi: 10.1016/j.clinbiochem.2019.05.010

Kuan, W. S., Ibrahim, I., Chan, S. P., Li, Z., Liew, O. W., Frampton, C., Troughton, R., Pemberton, C. J., … Richards, A. M. (2019). Mid-regional pro-adrenomedullin outperforms N-terminal pro-B-type natriuretic peptide for the diagnosis of acute heart failure in the presence of atrial fibrillation. European Journal of Heart Failure. Advance online publication. doi: 10.1002/ejhf.1660

Mulder, R., Zarifeh, J., Boden, J., Lacey, C., Tyrer, P., Tyrer, H., Than, M., & Troughton, R. (2019). An RCT of brief cognitive therapy versus treatment as usual in patients with non-cardiac chest pain. International Journal of Cardiology. Advance online publication. doi: 10.1016/j.ijcard.2019.01.067

Stamp, L. K., Frampton, C., Drake, J., Doughty, R. N., Troughton, R. W., & Richards, A. M. (2019). Associations of gout and baseline serum urate with cardiovascular outcomes: Analysis of the Coronary Disease Cohort Study. Arthritis & Rheumatology. Advance online publication. doi: 10.1002/art.41007

Chapter in Book - Research

Chan, W., & Troughton, R. (2014). Pulmonary hypertension and cardiac resynchronization therapy: Evaluation prior to implantation and response to therapy. In C.-M. Yu, D. L. Hayes & A. Auricchio (Eds.), Cases in cardiac resynchronization therapy. (pp. 295-300). Philadelphia, PA: Saunders.

Richards, A. M., Troughton, R. W., & Nicholls, M. G. (2011). Natriuretic peptides for guidance of acute and chronic heart failure therapy. In J. L. Januzzi (Ed.), Cardiac biomarkers in clinical practice. (pp. 559-580). Sudbury, MA: Jones & Bartlett.

Troughton, R. W. (2010). Dilated cardiomyopathy. In M. J. Garcia (Ed.), Noninvasive cardiovascular imaging: A multimodality approach. (pp. 465-477). Philadelphia, PA: Lippincott Williams & Wilkins.

Troughton, R. W., & Richards, A. M. (2008). Natriuretic peptides for disease monitoring in patients with chronic heart failure. In J. A. de Lemos (Ed.), Biomarkers in heart disease. (pp. 140-160). Malden, MA: Blackwell.

Troughton, R. W., & Richards, A. M. (2008). Outpatient monitoring and treatment of chronic heart failure guided by NT-proBNP measurement. In A. Bayés-Genís & J. L. Januzzi (Eds.), NT-proBNP as a biomarker in cardiovascular diseases. (pp. 91-100). Thomson Reuters.

Troughton, R. W., Ritzema-Carter, J., & Nicholls, M. G. (2008). Role of neurohormones. In A. L. Klein & M. J. Garcia (Eds.), Diastology: Clinical approach to diastolic heart failure. (pp. 345-366). Philadelphia, PA: Saunders.

Richards, A. M., Nicholls, M. G., & Troughton, R. W. (1999). The pharmacotherapy of diuretics. In N. Sharpe (Ed.), Heart Failure Management 2000. (pp. 43-60). London: Martin Dunitz.

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Chapter in Book - Other

Richards, M., Troughton, R., Espiner, E., Cameron, V., Ellmers, L., Pilbrow, A., Charles, C., Rademaker, M., Pemberton, C., & Yandle, T. (2013). Christchurch Heart Institute. In P. Joyce, G. Nicholls, K. Thomas & T. Wilkinson (Eds.), The Christchurch experience: 40 years of research and teaching. (pp. 68-74). Christchurch, New Zealand: University of Otago.

Troughton, R., Lin, S., & Wong, J. (2004). Prosthetic heart valves. In Manual of Cardiovascular Medicine. (2nd ed.) (pp. 236-248). Philadelphia: Lippincott Williams and Wilkins.

Richards, A. M., Nicholls, M. G., & Troughton, R. W. (2000). Diuretic therapy: Essential in heart failure. In N. Sharpe (Ed.), Heart failure management. (pp. 43-59). United Kingdom: Martin Dunitz.

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Journal - Research Article

Prickett, T. C. R., Spittlehouse, J. K., Miller, A. L., Liau, Y., Kennedy, M. A., Cameron, V. A., Pearson, J. F., Boden, J. M., Troughton, R. W., & Espiner, E. A. (2019). Contrasting signals of cardiovascular health among natriuretic peptides in subjects without heart disease. Scientific Reports, 9, 12108. doi: 10.1038/s41598-019-48553-y

Mulder, R., Zarifeh, J., Boden, J., Lacey, C., Tyrer, P., Tyrer, H., Than, M., & Troughton, R. (2019). An RCT of brief cognitive therapy versus treatment as usual in patients with non-cardiac chest pain. International Journal of Cardiology. Advance online publication. doi: 10.1016/j.ijcard.2019.01.067

Stamp, L. K., Frampton, C., Drake, J., Doughty, R. N., Troughton, R. W., & Richards, A. M. (2019). Associations of gout and baseline serum urate with cardiovascular outcomes: Analysis of the Coronary Disease Cohort Study. Arthritis & Rheumatology. Advance online publication. doi: 10.1002/art.41007

Kuan, W. S., Ibrahim, I., Chan, S. P., Li, Z., Liew, O. W., Frampton, C., Troughton, R., Pemberton, C. J., … Richards, A. M. (2019). Mid-regional pro-adrenomedullin outperforms N-terminal pro-B-type natriuretic peptide for the diagnosis of acute heart failure in the presence of atrial fibrillation. European Journal of Heart Failure. Advance online publication. doi: 10.1002/ejhf.1660

Chew-Harris, J., Appleby, S., Richards, A. M., Troughton, R. W., & Pemberton, C. J. (2019). Analytical, biochemical and clearance considerations of soluble urokinase plasminogen activator receptor (suPAR) in healthy individuals. Clinical Biochemistry. Advance online publication. doi: 10.1016/j.clinbiochem.2019.05.010

Grodin, J. L., Liebo, M. J., Butler, J., Metra, M., Felker, G. M., Hernandez, A. F., … Troughton, R. W., & Tang, W. H. W. (2019). Prognostic implications of changes in amino-terminal pro-B-type natriuretic peptide in acute decompensated heart failure: Insights from ASCEND-HF. Journal of Cardiac Failure. Advance online publication. doi: 10.1016/j.cardfail.2019.04.002

Wong, L. L., Zou, R., Zhou, L., Lim, J. Y., Phua, D. C. Y., Liu, C., … Troughton, R., Cameron, V. A., … Richards, A. M. (2019). Combining circulating microRNA and NT-proBNP to detect and categorize heart failure subtypes. JACC, 73(11), 1300-1313. doi: 10.1016/j.jacc.2018.11.060

Tan, E. S. J., Tay, W. T., Teng, T.-H. K., Sim, D., Leong, K. T. G., Yeo, P. S. D., … Troughton, R. W., … Richards, A. M., … Lam, C. S. P. (2019). Ethnic differences in atrial fibrillation in patients with heart failure from Asia-Pacific. Heart. Advance online publication. doi: 10.1136/heartjnl-2018-314077

Adamson, P. D., McAllister, D., Pilbrow, A., Pickering, J. W., Poppe, K., Shah, A., Whalley, G., … Pemberton, C., Troughton, R. W., … Richards, A. M. (2019). Convalescent troponin and cardiovascular death following acute coronary syndrome. Heart. Advance online publication. doi: 10.1136/heartjnl-2019-315084

Neumann, J. T., Twerenbold, R., Ojeda, F., Sörensen, N. A., Chapman, A. R., Shah, A. S. V., … Pickering, J. W., Troughton, R. W., … Than, M., … Blankenberg, S. (2019). Application of high-sensitivity troponin in suspected myocardial infarction. New England Journal of Medicine, 380(26), 2529-2540. doi: 10.1056/NEJMoa1803377

Harris, S. L., Wolff, E., Beecroft, G., Troughton, R., & Austin, N. (2019). Neonatal oxygen saturation alarm compliance: Under recognized source of iatrogenic harm? An audit and survey of nursing opinion. Journal of Neonatal Nursing. Advance online publication. doi: 10.1016/j.jnn.2019.07.003

Pickering, J. W., Flaws, D., Smith, S. W., Greenslade, J., Cullen, L., Parsonage, W., … Richards, A. M., Troughton, R., Pemberton, C., George, P. M., & Than, M. P. (2018). A risk assessment score and initial high-sensitivity troponin combine to identify low risk of acute myocardial infarction in the emergency department. Academic Emergency Medicine, 25(4), 434-443. doi: 10.1111/acem.13343

Than, M. P., Pickering, J. W., Dryden, J. M., Lord, S. J., Aitken, S. A., Aldous, S. J., … Ardagh, M. W., … Callender, R., … Deely, J. M., … Ferrier, K. A., … Frampton, C. M. A., George, P. M., … Matthews, T. J. E., … Peckler, B. F., … Richards, A. M., … Simmonds, M. B., … Troughton, R. W., … on behalf of the ICare-ACS Implementation Group. (2018). ICare-ACS (improving care processes for patients with suspected acute coronary syndrome): A study of cross-system implementation of a national clinical pathway. Circulation, 137(4), 354-363. doi: 10.1161/circulationaha.117.031984

Prickett, T. C. R., Darlow, B. A., Troughton, R. W., Cameron, V. A., Elliott, J. M., Martin, J., Horwood, L. J., & Espiner, E. A. (2018). New insights into cardiac and vascular natriuretic peptides: Findings from young adults born with very low birth weight. Clinical Chemistry, 64(2), 363-373. doi: 10.1373/clinchem.2017.280354

Lam, C. S. P., Gamble, G. D., Ling, L. H., Sim, D., Leong, K. T. G., Yeo, P. S. D., … Cameron, V. A., … Troughton, R., Richards, A. M., & Doughty, R. N. (2018). Mortality associated with heart failure with preserved vs. reduced ejection fraction in a prospective international multi-ethnic cohort study. European Heart Journal, 39(20), 1170-1178. doi: 10.1093/eurheartj/ehy005

Pickering, J. W., Young, J. M., George, P. M., Watson, A. S., Aldous, S. J., Troughton, R. W., Pemberton, C. J., Richards, A. M., … Than, M. P. (2018). Validity of a novel point-of-care troponin assay for single-test rule-out of acute myocardial infarction. JAMA Cardiology, 3(11), 1108-1112. doi: 10.1001/jamacardio.2018.3368

van der Linden, N., Wildi, K., Twerenbold, R., Pickering, J. W., Than, M., Cullen, L., … Richards, A. M., Troughton, R., Pemberton, C., … Mueller, C. (2018). Combining high sensitivity cardiac troponin I and cardiac troponin T in the early diagnosis of acute myocardial infarction. Circulation, 138(10), 989-999. doi: 10.1161/circulationaha.117.032003

Harris, S. L., More, K., Dixon, B., Troughton, R., Pemberton, C., Horwood, J., Ellis, N., & Austin, N. (2018). Factors affecting N-terminal pro-B-type natriuretic peptide levels in preterm infants and use in determination of haemodynamic significance of patent ductus arteriosus. European Journal of Pediatrics, 177(4), 521-532. doi: 10.1007/s00431-018-3089-y

Marks, E. C. A., Wilkinson, T. M., Frampton, C. M., Skelton, L., Pilbrow, A. P., Yandle, T. G., Pemberton, C. J., … Whalley, G. A., … Troughton, R. W., … Cameron, V. A., Richards, A. M., Gieseg, S. P., & Palmer, B. R. (2018). Plasma levels of soluble VEGF receptor isoforms, circulating pterins and VEGF system SNPs as prognostic biomarkers in patients with acute coronary syndromes. BMC Cardiovascular Disorders, 18, 169. doi: 10.1186/s12872-018-0894-1

de Carvalho, L., Fong, A., Troughton, R., Yan, B. P., Chin, C.-T., Poh, S.-C., … Frampton, C., Richards, A. M., & Chan, M. Y. (2018). Prognostic implications of dual platelet reactivity testing in acute coronary syndrome. Thrombosis & Haemostasis, 118(2), 415-426. doi: 10.1160/TH17-08-0564

Than, M. P., Aldous, S. J., Troughton, R. W., Pemberton, C. J., Richards, A. M., Frampton, C. M. A., Florkowski, C. M., George, P. M., … Young, J. M., … Pickering, J. W. (2018). Detectable high-sensitivity cardiac troponin within the population reference interval conveys high 5-year cardiovascular risk: An observational study. Clinical Chemistry, 64(7), 1044-1053. doi: 10.1373/clinchem.2017.285700

de Carvalho, L. P., Tan, S. H., Ow, G.-S., Tang, Z., Ching, J., Kovalik, J.-P., … Richards, A. M., … Troughton, R. W., … Chan, M. Y. (2018). Plasma ceramides as prognostic biomarkers and their arterial and myocardial tissue correlates in acute myocardial infarction. JACC: Basic to Translational Science, 3(2), 163-175. doi: 10.1016/j.jacbts.2017.12.005

Kavsak, P. A., Neumann, J. T., Cullen, L., Than, M., Shortt, C., Greenslade, J. H., Pickering, J. W., … Troughton, R., … Worster, A. (2018). Clinical chemistry score versus high-sensitivity cardiac troponin I and T tests alone to identify patients at low or high risk for myocardial infarction or death at presentation to the emergency department. CMAJ, 190(33), E974-E984. doi: 10.1503/cmaj.180144

McDonald, K., Troughton, R., Dahlström, U., Dargie, H., Krum, H., van der Meer, P., … Richards, M., & Doughty, R. (2018). Daily home BNP monitoring in heart failure for prediction of impending clinical deterioration: Results from the HOME HF study. European Journal of Heart Failure, 20(3), 474-480. doi: 10.1002/ejhf.1053

Prickett, T. C. R., Doughty, R. N., Troughton, R. W., Frampton, C. M., Whalley, G. A., Ellis, C. J., Espiner, E. A., & Richards, A. M. (2017). C-type natriuretic peptides in coronary disease. Clinical Chemistry, 63(1), 316-324. doi: 10.1373/clinchem.2016.257816

Pickering, J. W., Than, M. P., Cullen, L., Aldous, S., ter Avest, E., Body, R., … Florkowski, C. M., … George, P., … Pemberton, C., Richards, A. M., … Troughton, R., … Young, J. (2017). Rapid rule-out of acute myocardial infarction with a single high-sensitivity cardiac troponin T measurement below the limit of detection: A collaborative meta-analysis. Annals of Internal Medicine, 166(10), 715-724. doi: 10.7326/m16-2562

Ibrihim, I., Kuan, W. S., Frampton, C., Troughton, R., Liew, O. W., Chong, J. P. C., … Pemberton, C. J., … Richards, A. M. (2017). Superior performance of N-terminal pro brain natriuretic peptide for diagnosis of acute decompensated heart failure in an Asian compared with a Western setting. European Journal of Heart Failure, 19(2), 209-217. doi: 10.1002/ejhf.612

Elliott, J. M., Wang, T. K. M., Gamble, G., Williams, M., Matsis, P., Troughton, R., … Mann, S., Richards, M., … Ellis, C. (2017). A decade of improvement in the management of New Zealand ST-elevation myocardial infarction (STEMI) patients: Results from the New Zealand Acute Coronary Syndrome (ACS) Audit Group national audits of 2002, 2007 and 2012. New Zealand Medical Journal, 130(1453), 17-28. Retrieved from https://www.nzma.org.nz/journal

Than, M. P., Pickering, J. W., Aldous, S. J., Cullen, L., Frampton, C. M. A., Peacock, W. F., … Richards, A. M., Ardagh, M. W., Deely, J. M., Florkowski, C. M., George, P., Hamilton, G. J., Jardine, D. L., Troughton, R. W., … Lord, S. J. (2016). Effectiveness of EDACS versus ADAPT accelerated diagnostic pathways for chest pain: A pragmatic randomized controlled trial embedded within practice. Annals of Emergency Medicine, 68(1), 93-102. doi: 10.1016/j.annemergmed.2016.01.001

Pemberton, C. J., Frampton, C. M., Aldous, S., Bailey, M., Young, J., Troughton, R., Than, M., & Richards, M. (2016). B-type natriuretic peptide signal peptide (BNPsp) in patients presenting with chest pain. Clinical Biochemistry, 49, 645-650. doi: 10.1016/j.clinbiochem.2016.02.015

Young, J. M., Pickering, J. W., George, P. M., Aldous, S. J., Wallace, J., Frampton, C. M., Troughton, R. W., Richards, A. M., … Than, M. P. (2016). Heart Fatty Acid Binding Protein and cardiac troponin: Development of an optimal rule-out strategy for acute myocardial infarction. BMC Emergency Medicine, 16(1), 34. doi: 10.1186/s12873-016-0089-y

Pilbrow, A. P., Lewis, K. A., Perrin, M. H., Sweet, W. E., Moravec, C. S., Tang, W. H. W., … Troughton, R. W., & Cameron, V. A. (2016). Cardiac CRFR1 expression is elevated in human heart failure and modulated by genetic variation and alternative splicing. Endocrinology, 157(12), 4865-4874. doi: 10.1210/en.2016-1448

Tang, W. H. W., Wu, Y., Grodin, J. L., Hsu, A. P., Fernandez, A., Butler, J., … Troughton, R. W., … Starling, R. C. (2016). Prognostic value of baseline and changes in circulating soluble ST2 levels and the effects of nesiritide in acute decompensated heart failure. JACC: Heart Failure, 4(1), 68-77. doi: 10.1016/j.jchf.2015.07.015

Devlin, G., Williams, M., Elliott, J., White, H., French, J., Gamble, G., Matsis, P., Troughton, R., Richards, M., & Ellis, C. (2016). Management of non ST-elevation acute coronary syndrome patients in New Zealand: A longitudinal analysis: Results from the New Zealand Acute Coronary Syndrome national audits of 2002, 2007 and 2012. New Zealand Medical Journal, 129(1428), 9-15. Retrieved from https://www.nzma.org.nz/journal

Williams, M. J. A., Harding, S. A., Devlin, G., Nunn, C., El-Jack, S., Scott, T., … on behalf of the ANZACS-QI Investigators, including Matsis, P., Smyth, D., Blake, J., Elliott, J., Lainchbury, J., Bridgman, P., Troughton, R., Wilkins, G., Green, B., Edmond, J., & Milburn, K. (2016). National variation in coronary angiography rates and timing after an acute coronary syndrome in New Zealand (ANZACS-QI 6). New Zealand Medical Journal, 129(1428), 65-77. Retrieved from https://www.nzma.org.nz/journal

Pickering, J. W., Young, J. M., George, P., Aldous, S., Cullen, L., Greenslade, J. H., Richards, A. M., Troughton, R., Ardagh, M., Frampton, C. M., & Than, M. P. (2015). The utility of presentation and 4-hour high sensitivity troponin I to rule-out acute myocardial infarction in the emergency department. Clinical Biochemistry, 48(18), 1219-1224. doi: 10.1016/j.clinbiochem.2015.07.033

Ellis, C., Hammett, C., Ranasinghe, I., French, J., Briffa, T., Devlin, G., Elliott, J., … Williams, M., Troughton, R., … on behalf of Bi-National Acute Coronary Syndromes (ACS) 'SNAPSHOT' Audit Group. (2015). Comparison of the management and in-hospital outcomes of acute coronary syndrome patients in Australia and New Zealand: Results from the binational SNAPSHOT acute coronary syndrome 2012 audit. Internal Medicine Journal, 45(5), 497-509. doi: 10.1111/imj.12739

Tang, W. H. W., Dupont, M., Hernandez, A. F., Voors, A. A., Hsu, A. P., Felker, G. M., … Troughton, R. W., … Starling, R. C. (2015). Comparative assessment of short-term adverse events in acute heart failure with cystatin C and other estimates of renal function: Results from the ASCEND-HF trial. JACC: Heart Failure, 3(1), 40-49. doi: 10.1016/j.jchf.2014.06.014

The EchoNoRMAL (Echocardiographic Normal Ranges Meta-Analysis of the Left Heart) Collaboration, including Whalley, G. A., Cameron, V., Richards, A. M., & Troughton, R. (2015). Ethnic-specific normative reference values for echocardiographic LA and LV size, LV mass, and systolic function: The EchoNoRMAL Study. JACC: Cardiovascular Imaging, 8(6), 656-665. doi: 10.1016/j.jcmg.2015.02.014

Lee, J., Young, J., Frampton, C. M., Aldous, S., Troughton, R. W., Than, M., Richards, A. M., & Pemberton, C. J. (2015). A novel troponin T peptide in humans: Assay, biochemistry and preliminary findings in acute coronary syndromes. International Journal of Cardiology, 190, 68-74. doi: 10.1016/j.ijcard.2015.04.145

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