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Professor Richard W. Troughton

Richard Troughton

MB ChB(Auck) PhD(Otago) FRACP

Email richard.troughton@cdhb.health.nz

Department of Medicine
University of Otago, Christchurch
PO Box 4345
Christchurch
New Zealand

Current roles

  • Professor in Medicine
  • Cardiologist

Research interests

  • Neurohormonal control of cardiovascular and renal function
  • Heart Failure
  • Echocardiography
  • Left Ventricular Diastolic Function
  • Novel monitoring devices for heart failure

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Publications

Pickering, J. W., Scrase, R., Troughton, R., & Jamieson, H. A. (2022). Evaluation of the added value of Brain Natriuretic Peptide to a validated mortality risk-prediction model in older people using a standardised international clinical assessment tool. PLoS ONE, 17(11), e0277850. doi: 10.1371/journal.pone.0277850

Colin-Ramirez, E., Sepehrvand, N., Rathwell, S., Ross, H., Escobedo, J., Macdonald, P., Troughton, R., … Ezekowitz, J. A. (2022). Sodium restriction in patients with heart failure: A systematic review and meta-analysis of randomized clinical trials. Circulation: Heart Failure. Advance online publication. doi: 10.1161/circheartfailure.122.009879

Ward, Z., Schmeier, S., Pearson, J., Cameron, V. A., Frampton, C. M., Troughton, R. W., … Richards, A. M., & Pilbrow, A. P. (2022). Identifying candidate circulating RNA markers for coronary artery disease by deep RNA-sequencing in human plasma. Cell, 11, 3191. doi: 10.3390/cells11203191

Tragante, V., Poppe, K., Cameron, V. A., Jones, G. T., Frampton, C. M., Troughton, R. W., Richards, A. M., … Pilbrow, A. P. (2022, August). Predicting progression from coronary artery disease to heart failure. Verbal presentation at the Metabolic & Cardiovascular Disease Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.

Armstrong, P. W., Zheng, Y., Troughton, R. W., Lund, L. H., Zhang, J., Lam, C. S. P., … on behalf of the VICTORIA Study Group. (2022). Sequential evaluation of NT-proBNP in heart failure: Insights Into clinical outcomes and efficacy of vericiguat. JACC: Heart Failure. Advance online publication. doi: 10.1016/j.jchf.2022.04.015

Chan, W., & Troughton, R. (2014). Pulmonary hypertension and cardiac resynchronization therapy: Evaluation prior to implantation and response to therapy. In C.-M. Yu, D. L. Hayes & A. Auricchio (Eds.), Cases in cardiac resynchronization therapy. (pp. 295-300). Philadelphia, PA: Saunders.

Chapter in Book - Research

Richards, A. M., Troughton, R. W., & Nicholls, M. G. (2011). Natriuretic peptides for guidance of acute and chronic heart failure therapy. In J. L. Januzzi (Ed.), Cardiac biomarkers in clinical practice. (pp. 559-580). Sudbury, MA: Jones & Bartlett.

Chapter in Book - Research

Troughton, R. W. (2010). Dilated cardiomyopathy. In M. J. Garcia (Ed.), Noninvasive cardiovascular imaging: A multimodality approach. (pp. 465-477). Philadelphia, PA: Lippincott Williams & Wilkins.

Chapter in Book - Research

Troughton, R. W., & Richards, A. M. (2008). Natriuretic peptides for disease monitoring in patients with chronic heart failure. In J. A. de Lemos (Ed.), Biomarkers in heart disease. (pp. 140-160). Malden, MA: Blackwell.

Chapter in Book - Research

Troughton, R. W., & Richards, A. M. (2008). Outpatient monitoring and treatment of chronic heart failure guided by NT-proBNP measurement. In A. Bayés-Genís & J. L. Januzzi (Eds.), NT-proBNP as a biomarker in cardiovascular diseases. (pp. 91-100). Thomson Reuters.

Chapter in Book - Research

Troughton, R. W., Ritzema-Carter, J., & Nicholls, M. G. (2008). Role of neurohormones. In A. L. Klein & M. J. Garcia (Eds.), Diastology: Clinical approach to diastolic heart failure. (pp. 345-366). Philadelphia, PA: Saunders.

Chapter in Book - Research

Richards, A. M., Nicholls, M. G., & Troughton, R. W. (1999). The pharmacotherapy of diuretics. In N. Sharpe (Ed.), Heart Failure Management 2000. (pp. 43-60). London: Martin Dunitz.

Chapter in Book - Research

Richards, M., Troughton, R., Espiner, E., Cameron, V., Ellmers, L., Pilbrow, A., Charles, C., Rademaker, M., Pemberton, C., & Yandle, T. (2013). Christchurch Heart Institute. In P. Joyce, G. Nicholls, K. Thomas & T. Wilkinson (Eds.), The Christchurch experience: 40 years of research and teaching. (pp. 68-74). Christchurch, New Zealand: University of Otago.

Chapter in Book - Other

Troughton, R., Lin, S., & Wong, J. (2004). Prosthetic heart valves. In Manual of Cardiovascular Medicine. (2nd ed.) (pp. 236-248). Philadelphia: Lippincott Williams and Wilkins.

Chapter in Book - Other

Richards, A. M., Nicholls, M. G., & Troughton, R. W. (2000). Diuretic therapy: Essential in heart failure. In N. Sharpe (Ed.), Heart failure management. (pp. 43-59). United Kingdom: Martin Dunitz.

Chapter in Book - Other

Al-Busaidi, I. S., Clare, G. C., Joyce, L. R., Pearson, S., Lainchbury, J., Than, M., & Troughton, R. W. (2022). Presentation, treatment and long-term outcomes of a multidisciplinary acute atrial fibrillation pathway: A 12-month follow-up study. Heart, Lung & Circulation, 31, 216-226. doi: 10.1016/j.hlc.2021.05.102

Journal - Research Article

Armstrong, P. W., Zheng, Y., Troughton, R. W., Lund, L. H., Zhang, J., Lam, C. S. P., … on behalf of the VICTORIA Study Group. (2022). Sequential evaluation of NT-proBNP in heart failure: Insights Into clinical outcomes and efficacy of vericiguat. JACC: Heart Failure. Advance online publication. doi: 10.1016/j.jchf.2022.04.015

Journal - Research Article

Brodie, T., Landers, A., & Troughton, R. (2022). Deactivation of implantable cardioverter defibrillators towards the end of life: A survey of perceptions and practice among New Zealand clinicians. New Zealand Medical Journal, 135(1554), 20-34. Retrieved from https://www.nzma.org.nz/journal

Journal - Research Article

Colin-Ramirez, E., Sepehrvand, N., Rathwell, S., Ross, H., Escobedo, J., Macdonald, P., Troughton, R., … Ezekowitz, J. A. (2022). Sodium restriction in patients with heart failure: A systematic review and meta-analysis of randomized clinical trials. Circulation: Heart Failure. Advance online publication. doi: 10.1161/circheartfailure.122.009879

Journal - Research Article

Ezekowitz, J. A., Colin-Ramirez, E., Ross, H., Escobedo, J., MacDonald, P., Troughton, R., … on behalf of the SODIUM-HF Investigators. (2022). Reduction of dietary sodium to less than 100 mmol in heart failure (SODIUM-HF): An international, open-label, randomised, controlled trial. Lancet, 399, 1391-1400. doi: 10.1016/S0140-6736(22)00369-5

Journal - Research Article

Fitzsimons, S., Poppe, K. K., Choi, Y., Devlin, G., Lund, M., Lam, C. S. P., Troughton, R., Richards, A. M., & Doughty, R. N. (2022). Relationship between soluble transferrin receptor and clinical outcomes in patients with heart failure according to ejection fraction phenotype: The New Zealand PEOPLE study. Journal of Cardiac Failure, 28(8), 1255-1263. doi: 10.1016/j.cardfail.2021.12.018

Journal - Research Article

Pickering, J. W., Scrase, R., Troughton, R., & Jamieson, H. A. (2022). Evaluation of the added value of Brain Natriuretic Peptide to a validated mortality risk-prediction model in older people using a standardised international clinical assessment tool. PLoS ONE, 17(11), e0277850. doi: 10.1371/journal.pone.0277850

Journal - Research Article

Vergaro, G., Aimo, A., Januzzi, Jr, J. L., Richards, A. M., Lam, C. S. P., Latini, R., … Troughton, R., … Passino, C. (2022). Cardiac biomarkers retain prognostic significance in patients with heart failure and chronic obstructive pulmonary disease. Journal of Cardiovascular Medicine, 23(1), 28-36. doi: 10.2459/jcm.0000000000001281

Journal - Research Article

Vergaro, G., Gentile, F., Aimo, A., Januzzi, Jr, J. L., Richards, A. M., Lam, C. S. P., … Troughton, R., … Emdin, M. (2022). Circulating levels and prognostic cut-offs of sST2, hs-cTnT, and NT-proBNP in women vs. men with chronic heart failure. ESC Heart Failure. Advance online publication. doi: 10.1002/ehf2.13883

Journal - Research Article

Ward, Z., Schmeier, S., Pearson, J., Cameron, V. A., Frampton, C. M., Troughton, R. W., … Richards, A. M., & Pilbrow, A. P. (2022). Identifying candidate circulating RNA markers for coronary artery disease by deep RNA-sequencing in human plasma. Cell, 11, 3191. doi: 10.3390/cells11203191

Journal - Research Article

Winkle, P., Goldsmith, S., Koren, M. J., Lepage, S., Hellawell, J., Trivedi, A., … Troughton, R., … Neutel, J. (2022). A first-in-human study of AMG 986, a novel apelin receptor agonist, in healthy subjects and heart failure patients. Cardiovascular Drugs & Therapy. Advance online publication. doi: 10.1007/s10557-022-07328-w

Journal - Research Article

Yang, J., Epton, M. J., Harris, S. L., Horwood, J., Kingsford, R. A., Troughton, R., Greer, C., & Darlow, B. A. (2022). Reduced exercise capacity in adults born at very low birth weight: A population-based cohort study. American Journal of Respiratory & Critical Care Medicine, 205, 88-98. doi: 10.1164/rccm.202103-0755OC

Journal - Research Article

Fitzsimons, S., Yeo, T. J., Ling, L. H., Sim, D., Leong, K. T. G., Yeo, P. S. D., … Troughton, R., … Richards, A. M., & Doughty, R. N. (2021). Impact of change in iron status over time on clinical outcomes in heart failure according to ejection fraction phenotype. ESC Heart Failure. Advance online publication. doi: 10.1002/ehf2.13617

Journal - Research Article

Greer, C., Harris, S. L., Troughton, R., Adamson, P. D., Horwood, J., Frampton, C., & Darlow, B. A. (2021). Right ventricular structure and function in young adults born preterm at very low birth weight. Journal of Clinical Medicine, 10(21), 4864. doi: 10.3390/jcm10214864

Journal - Research Article

Harris, S., Perston, L., More, K., Graham, P., Ellis, N., Frampton, C., Troughton, R., Moor, S., & Austin, N. (2021). Cardiac structure and function in very preterm-born adolescents compared to term-born controls: A longitudinal cohort study. Early Human Development, 163, 105505. doi: 10.1016/j.earlhumdev.2021.105505

Journal - Research Article

Lassé, M., Pilbrow, A. P., Kleffmann, T., Andersson Överström, E., von Zychlinski, A., Frampton, C. M. A., … Troughton, R. W., Lewis, L. K., Prickett, T. C. R., Pemberton, C. J., Richards, A. M., & Cameron, V. A. (2021). Fibrinogen and hemoglobin predict near future cardiovascular events in asymptomatic individuals. Scientific Reports, 11(1), 4605. doi: 10.1038/s41598-021-84046-7

Journal - Research Article

McAlister, C. P., Yi, M., Adamson, P. D., Troughton, R. W., Rhodes, M., Blake, J. W. H., … Elliott, J. M., … Puri, A. (2021). Trends in the detection, management and 30-day outcomes of spontaneous coronary artery dissection: A six-year, New Zealand centre experience. Heart, Lung & Circulation, 30, 78-85. doi: 10.1016/j.hlc.2020.06.020

Journal - Research Article

Palmer, B. R., Paterson, M. A., Frampton, C. M., Pilbrow, A. P., Skelton, L., Pemberton, C. J., … Troughton, R. W., Richards, A. M., & Cameron, V. A. (2021). Vascular endothelial growth factor-A promoter polymorphisms, circulating VEGF-A and survival in acute coronary syndromes. PLoS ONE, 16(7), e0254206. doi: 10.1371/journal.pone.0254206

Journal - Research Article

Singh, S., de Ronde, M. W. J., Creemers, E. E., Van der Made, I., Meijering, R., Chan, M. Y., … Richards, A. M., Troughton, R. W., … Pinto-Sietsma, S. J. (2021). Low miR-19b-1-5p Expression is related to aspirin resistance and major adverse cardio- cerebrovascular events in patients with acute coronary syndrome. Journal of the American Heart Association, 10(2), e017120. doi: 10.1161/jaha.120.017120

Journal - Research Article

Aimo, A., Januzzi, Jr, J. L., Vergaro, G., Richards, A. M., Lam, C. S. P., Latini, R., … Troughton, R., … Edmin, M. (2020). Circulating levels and prognostic value of soluble ST2 in heart failure are less influenced by age than N-terminal pro-B-type natriuretic peptide and high-sensitivity troponin T. European Journal of Heart Failure, 22, 2078-2088. doi: 10.1002/ejhf.1701

Journal - Research Article

Appleby, S., Chew-Harris, J., Troughton, R. W., Richards, A. M., & Pemberton, C. J. (2020). Analytical and biological assessment of circulating human erythroferrone. Clinical Biochemistry, 79, 41-47. doi: 10.1016/j.clinbiochem.2020.02.001

Journal - Research Article

Chan, M. Y., Efthymios, M., Tan, S. H., Pickering, J. W., Troughton, R., Pemberton, C., … Pilbrow, A., & Richards, A. M. (2020). Prioritizing candidates of post-myocardial infarction heart failure using plasma proteomics and single-cell transcriptomics. Circulation, 142, 1408-1421. doi: 10.1161/circulationaha.119.045158

Journal - Research Article

Ezekowitz, J. A., O'Connor, C. M., Troughton, R. W., Alemayehu, W. G., Westerhout, C. M., Voors, A. A., … Armstrong, P. W. (2020). N-terminal pro−B-type natriuretic peptide and clinical outcomes: Vericiguat heart failure with reduced ejection fraction study. JACC: Heart Failure, 8(11), 931-939. doi: 10.1016/j.jchf.2020.08.008

Journal - Research Article

Harris, S. L., Bray, H., Troughton, R., Elliott, J., Frampton, C., Horwood, J., & Darlow, B. A. (2020). Cardiovascular outcomes in young adulthood in a population-based very low birth weight cohort. Journal of Pediatrics, 225, 74-79.e3. doi: 10.1016/j.jpeds.2020.06.023

Journal - Research Article

Harris, S. L., Troughton, R., Lewis, L., Austin, N., & Pemberton, C. (2020). Circulating forms of B-type natriuretic peptide in very preterm infants. Journal of Applied Laboratory Medicine, 5(3), 506-515. doi: 10.1093/jalm/jfaa003

Journal - Research Article

Harris, S. L., Wolff, E., Beecroft, G., Troughton, R., & Austin, N. (2020). Neonatal oxygen saturation alarm compliance: Under recognized source of iatrogenic harm? An audit and survey of nursing opinion. Journal of Neonatal Nursing, 26, 43-48. doi: 10.1016/j.jnn.2019.07.003

Journal - Research Article

Kuan, W. S., Ibrahim, I., Chan, S. P., Li, Z., Liew, O. W., Frampton, C., Troughton, R., Pemberton, C. J., … Richards, A. M. (2020). Mid-regional pro-adrenomedullin outperforms N-terminal pro-B-type natriuretic peptide for the diagnosis of acute heart failure in the presence of atrial fibrillation. European Journal of Heart Failure, 22, 692-700. doi: 10.1002/ejhf.1660

Journal - Research Article

Pickering, J. W., Young, J. M., George, P. M., Pemberton, C. J., Watson, A., Aldous, S. J., … Troughton, R. W., Richards, A. M., … Than, M. P. (2020). Early kinetic profiles of troponin I and T measured by high-sensitivity assays in patients with myocardial infarction. Clinica Chimica Acta, 505, 15-25. doi: 10.1016/j.cca.2020.02.009

Journal - Research Article

Prickett, T. C. R., Troughton, R. W., & Espiner, E. A. (2020). Effect of statin therapy on plasma C-type natriuretic peptides and endothelin-1 in males with and without symptomatic coronary artery disease. Scientific Reports, 10, 7927. doi: 10.1038/s41598-020-64795-7

Journal - Research Article

Adamson, P. D., McAllister, D., Pilbrow, A., Pickering, J. W., Poppe, K., Shah, A., Whalley, G., … Pemberton, C., Troughton, R. W., … Richards, A. M. (2019). Convalescent troponin and cardiovascular death following acute coronary syndrome. Heart, 105, 1717-1724. doi: 10.1136/heartjnl-2019-315084

Journal - Research Article

Chew-Harris, J., Appleby, S., Richards, A. M., Troughton, R. W., & Pemberton, C. J. (2019). Analytical, biochemical and clearance considerations of soluble urokinase plasminogen activator receptor (suPAR) in healthy individuals. Clinical Biochemistry, 69, 36-44. doi: 10.1016/j.clinbiochem.2019.05.010

Journal - Research Article

Grodin, J. L., Liebo, M. J., Butler, J., Metra, M., Felker, G. M., Hernandez, A. F., … Troughton, R. W., & Tang, W. H. W. (2019). Prognostic implications of changes in amino-terminal pro-B-type natriuretic peptide in acute decompensated heart failure: Insights from ASCEND-HF. Journal of Cardiac Failure, 25(9), 703-711. doi: 10.1016/j.cardfail.2019.04.002

Journal - Research Article

Mulder, R., Zarifeh, J., Boden, J., Lacey, C., Tyrer, P., Tyrer, H., Than, M., & Troughton, R. (2019). An RCT of brief cognitive therapy versus treatment as usual in patients with non-cardiac chest pain. International Journal of Cardiology, 289, 6-11. doi: 10.1016/j.ijcard.2019.01.067

Journal - Research Article

Neumann, J. T., Twerenbold, R., Ojeda, F., Sörensen, N. A., Chapman, A. R., Shah, A. S. V., … Pickering, J. W., Troughton, R. W., … Than, M., … Blankenberg, S. (2019). Application of high-sensitivity troponin in suspected myocardial infarction. New England Journal of Medicine, 380(26), 2529-2540. doi: 10.1056/NEJMoa1803377

Journal - Research Article

Poppe, K. K., Doughty, R. N., Wells, S., Wu, B., Earle, N. J., Richards, A. M., Troughton, R. W., … Kerr, A. J. (2019). Development and validation of a cardiovascular risk score for patients in the community after acute coronary syndrome. Heart, 106, 506-511. doi: 10.1136/heartjnl-2019-315809

Journal - Research Article

Prickett, T. C. R., Spittlehouse, J. K., Miller, A. L., Liau, Y., Kennedy, M. A., Cameron, V. A., Pearson, J. F., Boden, J. M., Troughton, R. W., & Espiner, E. A. (2019). Contrasting signals of cardiovascular health among natriuretic peptides in subjects without heart disease. Scientific Reports, 9, 12108. doi: 10.1038/s41598-019-48553-y

Journal - Research Article

Tan, E. S. J., Tay, W. T., Teng, T.-H. K., Sim, D., Leong, K. T. G., Yeo, P. S. D., … Troughton, R. W., … Richards, A. M., … Lam, C. S. P. (2019). Ethnic differences in atrial fibrillation in patients with heart failure from Asia-Pacific. Heart, 105, 842-847. doi: 10.1136/heartjnl-2018-314077

Journal - Research Article

Wong, L. L., Zou, R., Zhou, L., Lim, J. Y., Phua, D. C. Y., Liu, C., … Troughton, R., Cameron, V. A., … Richards, A. M. (2019). Combining circulating microRNA and NT-proBNP to detect and categorize heart failure subtypes. JACC, 73(11), 1300-1313. doi: 10.1016/j.jacc.2018.11.060

Journal - Research Article

de Carvalho, L. P., Tan, S. H., Ow, G.-S., Tang, Z., Ching, J., Kovalik, J.-P., … Richards, A. M., … Troughton, R. W., … Chan, M. Y. (2018). Plasma ceramides as prognostic biomarkers and their arterial and myocardial tissue correlates in acute myocardial infarction. JACC: Basic to Translational Science, 3(2), 163-175. doi: 10.1016/j.jacbts.2017.12.005

Journal - Research Article

de Carvalho, L., Fong, A., Troughton, R., Yan, B. P., Chin, C.-T., Poh, S.-C., … Frampton, C., Richards, A. M., & Chan, M. Y. (2018). Prognostic implications of dual platelet reactivity testing in acute coronary syndrome. Thrombosis & Haemostasis, 118(2), 415-426. doi: 10.1160/TH17-08-0564

Journal - Research Article

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