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Dr Michael J. Burt

Michael Burt

BMedSc MB ChB(Otago) PhD(Q'ld) FRACP

Email michael.burt@cdhb.govt.nz

Department of Gastroenterology
Christchurch Hospital
Private Bag 4710
Christchurch
New Zealand

Current Roles

  • Senior Lecturer in Medicine
  • Consultant Gastroenterologist, Christchurch Hospital

Research Interests

  • Liver disease
  • Inflammatory bowel disease

Top 10 Publications

  • Burt MJ, Smit DJ, Pyper WR, Powell LW, Jazwinska EC. A 4.5 megabase YAC contig and physical map over the hemochromatosis gene region. Genomics 1996; 33: 153-8.
  • Burt MJ, George PM, Upton JD, Collett JA, Frampton CMA, Chapman TM, Walmsley TA, Chapman BA. The significance of haemochromatosis gene mutations in the general population: implications for screening. Gut 1998; 43: 830-6.
  • Chapman BA, Burt MJ, Chisholm RJ, Allan RB, Yeo KHJ, Ross AG. Dissolution of gallstones with simvastatin, an HMG CoA reductase inhibitor. Dig Dis Sci 1998; 43: 349-53.
  • Thomas PD, Turner JG, Dobbs BR, Burt MJ, Chapman BA. Use of 99mTc-DISIDA biliary scanning with morphine provocation for the detection of elevated sphincter of Oddi basal pressure. Gut 2000; 46: 838-41
  • Cook HB, Burt MJ, Collett JA, Whitehead MR, Frampton CMA, Chapman BA. Adult coeliac disease: Prevalence and significance. J Gastroenterol Hepatol 2000; 15: 1032-1036.
  • Chapman BA, Burt MJ, Frampton CMA, Chapman TM, Whitehead MR, Upton JD, George PM. Influence of haemochromatosis gene mutations on treatment outcomes in patients with hepatitis C. Int Med J 2001; 31:254-5
  • Burt MJ, Frizelle FA, Barbezat GO. Pregnancy and Exposure to Infliximab (anti-tumor necrosis factor-alpha monoclonal antibody). J Gastroenterol Hepatol 2003; 18: 465-6.
  • Thiopurine S-methyltransferase (TPMT) genotype does not predict adverse drug reactions to thiopurine drugs in patients with inflammatory bowel disease. Gearry RB, Barclay ML, Burt MJ, Collett JA, Chapman BA, Roberts RL, Kennedy MA Aliment Pharmacol Ther 2003; 18: 395-400.
  • A thirty-year (1970-1999) study of coeliac disease in the Canterbury region of New Zealand. Cook HB, Oxner RB, Chapman BA, Frampton CMA, Burt MJ. NZ Med J 2004; www.nzma.org.nz/journal/117-1189/772
  • Surveillance for dysplasia in patients with inflammatory bowel disease: A national survey of colonoscopic practice in New Zealand. Gearry RB, Wakeman CJ, Barclay ML, Chapman BA, Collett JA, Burt MJ, Frizelle FA. Dis Colon Rectum 2004; 47: 314-22

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Publications

Lamba, M., Daker, C., Metcalf, S., Burt, M., Stedman, C., Chapman, B., & Ngu, J. (2018). Are patients with chronic hepatitis B receiving recommended HCC surveillance? Proceedings of the New Zealand Society of Gastroenterology and the NZNO Gastroenterology Nurses' College Annual Scientific Meeting. Retrieved from http://gastro2018.co.nz

Sanders, A. D., Stevenson, C., Pearson, J., Burt, M., McGeoch, G., Hudson, B., & Eglinton, T. W. (2013). A novel pathway for investigation of colorectal symptoms with colonoscopy or computed tomography colonography. New Zealand Medical Journal, 126(1382). Retrieved from http://www.nzma.org.nz/journal

Gardiner, S. J., Gearry, R. B., Burt, M. J., Chalmers-Watson, T., Chapman, B. A., Ross, A. G., Stedman, C. A. M., … Barclay, M. L. (2011). Allopurinol might improve response to azathioprine and 6-mercaptopurine by correcting an unfavorable metabolite ratio. Journal of Gastroenterology & Hepatology, 26(1), 49-54. doi: 10.1111/j.1440-1746.2010.06489.x

Ngu, J. H., Bechly, K., Chapman, B. A., Burt, M. J., Barclay, M. L., Gearry, R. B., & Stedman, C. A. M. (2010). Population-based epidemiology study of autoimmune hepatitis: A disease of older women? Journal of Gastroenterology & Hepatology, 25(10), 1681-1686. doi: 10.1111/j.1440-1746.2010.06384.x

Ngu, J. H., Wright, A., Gearry, R. B., Chapman, B. A., Burt, M. J., Barclay, M. L., & Stedman, C. A. M. (2010). Primary biliary cirrhosis in Canterbury, New Zealand: A population-based study. Journal of Gastroenterology and Hepatology. 25(Suppl. 2), (pp. A11). doi: 10.1111/j.1440-1746.2009.06462.x

Journal - Research Article

Sanders, A. D., Stevenson, C., Pearson, J., Burt, M., McGeoch, G., Hudson, B., & Eglinton, T. W. (2013). A novel pathway for investigation of colorectal symptoms with colonoscopy or computed tomography colonography. New Zealand Medical Journal, 126(1382). Retrieved from http://www.nzma.org.nz/journal

Gardiner, S. J., Gearry, R. B., Burt, M. J., Chalmers-Watson, T., Chapman, B. A., Ross, A. G., Stedman, C. A. M., … Barclay, M. L. (2011). Allopurinol might improve response to azathioprine and 6-mercaptopurine by correcting an unfavorable metabolite ratio. Journal of Gastroenterology & Hepatology, 26(1), 49-54. doi: 10.1111/j.1440-1746.2010.06489.x

Ngu, J. H., Bechly, K., Chapman, B. A., Burt, M. J., Barclay, M. L., Gearry, R. B., & Stedman, C. A. M. (2010). Population-based epidemiology study of autoimmune hepatitis: A disease of older women? Journal of Gastroenterology & Hepatology, 25(10), 1681-1686. doi: 10.1111/j.1440-1746.2010.06384.x

Roberts, R. L., Gearry, R. B., Bland, M. V., Sies, C. W., George, P. M., Burt, M., … Barclay, M. L., & Kennedy, M. A. (2008). Trinucleotide repeat variants in the promoter of the thiopurine S-methyltransferase gene of patients exhibiting ultra-high enzyme activity. Pharmacogenetics & Genomics, 18(5), 434-438.

Gardiner, S. J., Gearry, R. B., Burt, M. J., Ding, S. L., & Barclay, M. L. (2008). Severe hepatotoxicity with high 6-methylmercaptopurine nucleotide concentrations after thiopurine dose escalation due to low 6-thioguanine nucleotides. European Journal of Gastroenterology & Hepatology, 20(12), 1238-1242. doi: 10.1097/MEG.0b013e3282ffda37

Gearry, R. B., Roberts, R. L., Burt, M. J., Frampton, C. M. A., Chapman, B. A., Collett, J. A., Shirley, P., Allington, M. D. E., Kennedy, M. A., & Barclay, M. L. (2007). Effect of inflammatory bowel disease classification changes on NOD2 genotype-phenotype associations in a population-based cohort. Inflammatory Bowel Diseases, 13(10), 1220-1227.

Gearry, R. B., Richardson, A., Frampton, C. M., Collett, J. A., Burt, M. J., Chapman, B. A., & Barclay, M. L. (2006). High incidence of Crohn's disease in Canterbury, New Zealand: Results of an epidemiologic study. Inflammatory Bowel Diseases, 12(10), 936-943.

Gearry, R. B., Barclay, M. L., Burt, M. J., Collett, J. A., & Chapman, B. A. (2004). Thiopurine drug adverse effects in a population of New Zealand patients with inflammatory bowel disease. Pharmacoepidemiology & Drug Safety, 13(8), 563-567.

Cook, B., Oxner, R., Chapman, B., Whitehead, M., & Burt, M. (2004). A thirty-year (1970-1999) study of coeliac disease in the Canterbury region of New Zealand. New Zealand Medical Journal, 117(1189). Retrieved from http://journal.nzma.org.nz/journal/117-1189/772/content.pdf

Gearry, R. B., Wakeman, C. J., Barclay, M. L., Chapman, B. A., Collett, J. A., Burt, M. J., & Frizelle, F. A. (2004). Surveillance for dysplasia in patients with inflammatory bowel disease: A national survey of colonoscopic practice in New Zealand. Diseases of the Colon & Rectum, 47(3), 314-322.

Gearry, R. B., Barclay, M. L., Burt, M. J., Collett, J. A., Chapman, B. A., Roberts, R., & Kennedy, M. A. (2003). Thiopurine S-methyltransferase (TPMT) genotype does not predict adverse drug reactions to thiopurine drugs in patients with inflammatory bowel disease. Alimentary Pharmacology & Therapeutics, 18, 395-400.

Chapman, B. A., Burt, M. J., Frampton, C. M., Chapman, T. M., Whitehead, M. R., Upton, J. D., & George, P. M. (2001). The influence of haemochromatosis gene mutations on treatment outcome in patients with hepatitis C. Internal Medicine Journal, 31, 254-255.

Thomas, P. D., Turner, J. G., Dobbs, B. R., Burt, M. J., & Chapman, B. A. (2000). Use of 99mTc-DISIDA diliary scanning with morphine provocation for the detection of elevated shincter of Oddi basal pressure. Gut, 46, 838-841.

Cook, H. B., Burt, M. J., Collett, J. A., Whitehead, M. R., Frampton, C. M., & Chapman, B. A. (2000). Adult coeliac disease: Prevalence and significance. Journal of Gastroenterology & Hepatology, 15, 1032-1036.

Bramwell Cook, H., Burt, M. J., Collett, J. A., Whitehead, M. R., Frampton, C. M., & Chapman, B. A. (2000). Adult coeliac disease: Prevalence and clinical significance. Journal of Gastroenterology & Hepatology, 15(9), 1032-1036.

Stott, M. K., Fellowes, A. P., Upton, J. D., Burt, M. J., & George, P. M. (2000). Correction for Stoff et al: Simple multiplex PCR for the simultaneous detection of the C282Y and H63D hemochromatosis (HFE) gene mutations. Clinical Chemistry, 46, 308-309.

Chapman, B. A., Burt, M. J., Frampton, C. M., Collett, J. A., Yeo, K. H. J., Wilkinson, I. D., … Barclay, M. L., … George, P. M. (2000). The prevalence of viral hepatitis (HAV, HBV and HCV) in the Christchurch community. New Zealand Medical Journal, 113, 394-396.

Chapman, B. A., Burt, M. J., Frampton, C. M., Collett, J., Yeo, K. H. J., Wilkinson, I. D., … Barclay, M. L., … George, P. M. (2000). The prevalence of viral hepatitis (HAV, HBV & HCV) in the Christchurch community. New Zealand Medical Journal, 113(1118), 394-396.

Chapman, B. A., Frampton, C. M., Wilson, I. R., Chisholm, R. J., Allan, R. B., & Burt, M. J. (2000). Gallstone prevalence in Christchurch: Risk factors and clinical significance. New Zealand Medical Journal, 113, 46-48.

Collett, J. A., Burt, M. J., Frampton, C. M. A., Yeo, K. H. J., Chapman, T. M., Buttimore, R. C., … Chapman, B. A. (1999). Seroprevalence of helicobacter pylori in an adult population in Christchurch: Risk factors and relationship to dyspeptic symptoms. New Zealand Medical Journal, 112(1093), 292-295.

Collett, J. A., Burt, M. J., Frampton, C. M., Yeo, K. H. J., Chapman, T. M., Buttimore, R. C., … Chapman, B. A. (1999). Seroprevalence of Helicobacter pylori in the adult population of Christchurch: risk factors and relationship to dyspeptic symptoms and iron studies. New Zealand Medical Journal, 112, 292-295.

Stott, M. K., Fellowes, A. P., Upton, J. D., Burt, M. J., & George, P. M. (1999). Simple multiplex PCR for the simultaneous detection of the C282Y and H63D hemochromatosis (HFE) gene mutations. Clinical Chemistry, 45(3), 426-428.

Florkowski, C. M., George, P. M., Willis, J., Stott, M. K., Burt, M. J., Upton, J. D., … Scott, R. S. (1999). Haemochromatosis gene mutations Cys282Tyr and His63Asp are not increased in type 2 diabetic patients compared with the Canterbury (New Zealand) general population. Diabetes Research & Clinical Practice, 43, 199-203.

Collett, J. A., Allan, R., Chisholm, R. J., Wilson, I. R., Burt, M. J., & Chapman, B. A. (1998). Gallbladder polyps: A prospective study. Journal of Ultrasound in Medicine, 17(4), 207-211.

Collett, J. A., Allan, R. B., Chisholm, R. J., Wilson, I. R., Burt, M. J., & Chapman, B. A. (1998). Gallbladder polyps: prospective study. Journal of Ultrasound in Medicine, 17(4), 207-211.

Chapman, B. A., Chapman, T. M., Frampton, C. M., Chisholm, R. J., Allan, R. B., Wilson, I. R., & Burt, M. J. (1998). Gallbladder volume: comparison of diabetic and controls. Digestive Diseases & Sciences, 43(2), 344-348.

Chapman, B. A., Burt, M. J., Chisholm, R. J., Allan, R. B., Yeo, K. H. J., & Ross, A. G. (1998). Dissolution of gallstones with simvastatin, an HMG CoA reductase inhibitor. Digestive Diseases & Sciences, 43(2), 349-353.

Burt, M. J., George, P. M., Upton, J. D., Collett, J. A., Chapman, P. T., Walmsley, T. A., Chapman, B. A., & Frampton, C. M. (1998). The frequency and effect on iron indices of haemochromatosis (HFE) gene mutations. Gut, 43, 830-836.

Burt, M. J., George, P. M., Upton, J. D., Collett, J. A., Frampton, C. M., Chapman, B. A., … Walmsley, T. A. (1998). The frequency and significance of hemochromatosis (HFE) mutations in the general population. Gut, 43(6), 830-836.

Burt, M. J., & Cooksley, W. G. (1998). The influence of iron on chronic Hepatitis C. Journal of Gastroenterology & Hepatology, 13(3), 330-333.

Allardyce, R. A., Chapman, B. A., Tie, A. B., Burt, M. J., Yeo, K. J., Keenan, J. I., & Bagshaw, P. F. (1997). 37 kBq 14C-urea breath test and gastric biopsy analysis of H. pylori infection. Australian & New Zealand Journal of Surgery, 67(1), 31-34. doi: 10.1111/j.1445-2197.1997.tb01890.x

Frizelle, F. A., & Burt, M. J. (1997). Review: the surgical management of ulcerative colitis. Journal of Gastroenterology & Hepatology, 12(9/10), 670-677.

Burt, M. J., Upton, J. D., Morison, I. M., Chapman, B. A., Faed, J. M., & George, P. M. (1997). Molecular analysis of HLA-H gene mutations in New Zealand patients with haemochromatosis. New Zealand Medical Journal, 110(1056), 429-432.

Burt, M. J., Ross, A. G., Schroeder, B. A., Chambers, S., & Chapman, B. A. (1996). Evaluation of alpha inferferon for the treatment of chronic hepatitis B infection in Christchurch. New Zealand Medical Journal, 109, 162-164.

Burt, M. J., Smit, D. J., Pyper, W. R., Powell, L. W., & Jazwinska, E. C. (1996). A 4.5-megabase YAC contig and physical map over the hemochromatosis gene region. Genomics, 33, 153-158.

Burt, M. J., Jazwinska, E. C., Gill, D., Lynch, S. V., Kerlin, P., Steadman, C. J., … Powell, E. E. (1996). Detection of circulating donor DNA by microsatellite analysis in a liver transplant recipient. Liver Transplantation & Surgery, 2, 1-5.

Powell, L. W., Burt, M. J., Halliday, J. W., & Jazwinska, E. C. (1996). Hemochromatosis: genetics and pathogenesis. Seminars in Liver Disease, 16, 55-63.

Burt, M. J., George, D. K., & Powell, L. W. (1996). Haemochromatosis a clinical update. Medical Journal of Australia, 164, 348-351.

Pyper, W. R., Burt, M. J., Powell, L. W., Webb, S., Ades, L., Halliday, J. W., & Jazwinska, E. A. (1995). A region of primer binding variation at the D6S265 locus associated with HLA-A25 and HLA-A26 antigens. Human Genetics, 96, 490-492.

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Journal - Research Other

Ganly, P., Saleem, M., Marr, H., Burt, M., Florkowski, C., & Williamson, A. (2008). Not walking or communicating: Is all well? [Case report]. Lancet, 372(9655), 2086. doi: 10.1016/S0140-6736(08)61870-X

Burt, M. J., Frizelle, F. A., & Barbezat, G. O. (2003). Pregnancy and exposure to infliximab (anti-tumor necrosis factor-alpha monoclonal antibody) [Letter to the Editor]. Journal of Gastroenterology & Hepatology, 18, 465-466.

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Journal - Professional & Other Non-Research Articles

Gearry, R. B., Bramwell Cook, H., & Burt, M. J. (2003). Time for gastroscopy [Medical image]. New Zealand Medical Journal, 116(1168). Retrieved from http://journal.nzma.org.nz/journal/116-1168/309/content.pdf

Jazwinska, E. C., Cullen, L., Zournazi, A., Burt, M. J., van der Griend, B., Goldwurm, S., & Little, P. F. (1997). Isolation and characterisation of cosmids to intervals within a 4.5Mb region at 6p21.3. DNA Sequence, 8(3), 147-150.

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Conference Contribution - Published proceedings: Abstract

Lamba, M., Daker, C., Metcalf, S., Burt, M., Stedman, C., Chapman, B., & Ngu, J. (2018). Are patients with chronic hepatitis B receiving recommended HCC surveillance? Proceedings of the New Zealand Society of Gastroenterology and the NZNO Gastroenterology Nurses' College Annual Scientific Meeting. Retrieved from http://gastro2018.co.nz

Ngu, J. H., Wright, A., Gearry, R. B., Chapman, B. A., Burt, M. J., Barclay, M. L., & Stedman, C. A. M. (2010). Primary biliary cirrhosis in Canterbury, New Zealand: A population-based study. Journal of Gastroenterology and Hepatology. 25(Suppl. 2), (pp. A11). doi: 10.1111/j.1440-1746.2009.06462.x

Ngu, J. H., Wright, A., Gearry, R. B., Chapman, B. A., Burt, M. J., Barclay, M. L., & Stedman, C. A. M. (2010). Population-based epidemiology of primary sclerosing cholangitis in Canterbury, New Zealand. Journal of Gastroenterology and Hepatology. 25(Suppl. 2), (pp. A11). doi: 10.1111/j.1440-1746.2009.06462.x

Barclay, M. L., Gardiner, S. J., Gearry, R. B., Burt, M. J., Chalmers-Watson, T., Chapman, B. A., … Stedman, C. A. M. (2008). Allopurinol may improve response to azathioprine and 6-mercaptopurine by correcting an unfavorable metabolite ratio. Journal of Gastroenterology and Hepatology. 23(Suppl. 4), (pp. A194). [Abstract]

Barclay, M. L., Gardiner, S. J., Gearry, R. B., Burt, M. J., Chalmers-Watson, T., Chapman, B. A., … Stedman, C. A. M. (2008). Allopurinol may improve response to azathioprine and 6-mercaptopurine by correcting an unfavourable metabolite ratio. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Annual Scientific Meeting. ASCEPT. Retrieved from http://phal.otago.ac.nz/ascept_docos/programme%202008.pdf

Roberts, R. L., Gearry, R. B., Bland, M. V., Sies, C., George, P. M., Burt, M., Kennedy, M. A., & Barclay, M. L. (2007). Trinucleotide repeat variants in inflammatory bowel disease patients exhibiting ultra-high thiopurine S-methyltransferase activity. Proceedings of the 3rd Annual Carney Pharmacogenomics Symposium. Retrieved from http://www.chmeds.ac.nz/research/carneycentre/symposium.htm

Gearry, R. B., Frampton, C. M., Collett, J. A., Chapman, B. A., Burt, M. J., Shirley, P. M., & Barclay, M. L. (2007). Inflammatory bowel disease (IBD) related morbidity in a population-based cohort. Gut. 56(Suppl. III), (pp. A127). [Abstract]

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