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Dr Barry R Palmer

Barry Palmer

BSc(Hons) PhD(Otago)

Email barry.palmer@otago.ac.nz

Department of Medicine
University of Otago, Christchurch
PO Box 4345
Christchurch
New Zealand

Background

Dr Barry Palmer completed his PhD in Microbial Genetics at the University of Otago in 1988, on the topic of Restriction mapping of FP2, a conjugative plasmid of Pseudomonas aeruginosa.

He had postdoctoral training at the University of Massachusetts Medical School, Worcester, Massachusetts in 1988-90 specialising in DNA methylation and DNA repair in Escherichia coli.

On returning to New Zealand Barry lectured in Molecular Biology in the Department of Plant and Microbial Sciences at the University of Canterbury from 1990-94 and undertook research into the molecular genetics of Pseudomonas aeruginosa and Escherichia coli.

From 1994-2000 he was a Research Officer in the Animal and Food Sciences Division at the Lincoln University investigating the use of genetic markers to improve meat quality and yield in sheep.

Dr Palmer's recent genotyping projects at the Christchurch Heart Institute have included:

  • Gene variants from the human X-chromosome as prognostic markers in coronary heart disease
  • The VEGF system and survival in coronary heart disease

Current Roles

Research Interests

  • Human Molecular Genetics
  • Genetics of the X-chromosome
  • Animal Molecular Genetics
  • Molecular Microbiology

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Publications

Marks, E. C. A., Wilkinson, T. M., Frampton, C. M., Skelton, L., Pilbrow, A. P., Yandle, T. G., Pemberton, C. J., … Whalley, G. A., … Troughton, R. W., … Cameron, V. A., Richards, A. M., Gieseg, S. P., & Palmer, B. R. (2018). Plasma levels of soluble VEGF receptor isoforms, circulating pterins and VEGF system SNPs as prognostic biomarkers in patients with acute coronary syndromes. BMC Cardiovascular Disorders, 18, 169. doi: 10.1186/s12872-018-0894-1

Gieseg, S. P., Aamir, R., Anderson, N., Butler, A., Chen, A., Cross, S. P., … Palmer, B., Prebble, H. M., Roake, J. A., & White, V. (2016, August-September). Macrophage markers and plaque imaging. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.

Keogh, J. W. L., Palmer, B. R., Taylor, D., & Kilding, A. E. (2015). ACE and UCP2 gene polymorphisms and their association with baseline and exercise-related changes in the functional performance of older adults. PeerJ, 3, e980. doi: 10.7717/peerj.980

Palmer, B. R., Slow, S., Ellis, K. L., Pilbrow, A. P., Skelton, L., Frampton, C. M., Palmer, S. C., Troughton, R. W., Yandle, T. G., … Whalley, G. A., … Lever, M., George, P. M., Chambers, S. T., … Richards, A. M., & Cameron, V. A. (2014). Genetic polymorphism rs6922269 in the MTHFD1L gene is associated with survival and baseline active vitamin B12 levels in post-acute coronary syndromes patients. PLoS ONE, 9(3), e89029. doi: 10.1371/journal.pone.0089029

Cameron, V. A., Pilbrow, A. P., Ellis, K. L., Palmer, B. R., Troughton, R. W., & Richards, A. M. (2014). Duelling hormones: The renin-aldosterone system versus the natriuretic peptides in heart disease. Proceedings of the Medical Sciences Congress (MedSci). (pp. 15). Retrieved from http://www.physoc.org.nz/meetings/archive/medsci-2014-abstracts

Journal - Research Article

Marks, E. C. A., Wilkinson, T. M., Frampton, C. M., Skelton, L., Pilbrow, A. P., Yandle, T. G., Pemberton, C. J., … Whalley, G. A., … Troughton, R. W., … Cameron, V. A., Richards, A. M., Gieseg, S. P., & Palmer, B. R. (2018). Plasma levels of soluble VEGF receptor isoforms, circulating pterins and VEGF system SNPs as prognostic biomarkers in patients with acute coronary syndromes. BMC Cardiovascular Disorders, 18, 169. doi: 10.1186/s12872-018-0894-1

Keogh, J. W. L., Palmer, B. R., Taylor, D., & Kilding, A. E. (2015). ACE and UCP2 gene polymorphisms and their association with baseline and exercise-related changes in the functional performance of older adults. PeerJ, 3, e980. doi: 10.7717/peerj.980

Palmer, B. R., Slow, S., Ellis, K. L., Pilbrow, A. P., Skelton, L., Frampton, C. M., Palmer, S. C., Troughton, R. W., Yandle, T. G., … Whalley, G. A., … Lever, M., George, P. M., Chambers, S. T., … Richards, A. M., & Cameron, V. A. (2014). Genetic polymorphism rs6922269 in the MTHFD1L gene is associated with survival and baseline active vitamin B12 levels in post-acute coronary syndromes patients. PLoS ONE, 9(3), e89029. doi: 10.1371/journal.pone.0089029

Palmer, B. R., Frampton, C. M., Skelton, L., Yandle, T. G., Doughty, R. N., Whalley, G. A., … Troughton, R. W., Richards, A. M., & Cameron, V. A. (2012). KCNE5 polymorphism rs697829 is associated with QT interval and survival in acute coronary syndromes patients. Journal of Cardiovascular Electrophysiology, 23(3), 319-324. doi: 10.1111/j.1540-8167.2011.02192.x

Ellis, K. L., Palmer, B. R., Frampton, C. M., Troughton, R. W., Doughty, R. N., Whalley, G. A., … Pilbrow, A. P., Skelton, L., Yandle, T. G., Richards, A. M., & Cameron, V. A. (2012). Genetic variation in the renin-angiotensin-aldosterone system is associated with cardiovascular risk factors and early mortality in established coronary heart disease. Journal of Human Hypertension, 27, 237-244. doi: 10.1038/jhh.2012.24

Ellis, K. L., Pilbrow, A. P., Potter, H. C., Frampton, C. M., Doughty, R. N., Whalley, G. A., … Palmer, B. R., Skelton, L., Yandle, T. G., Troughton, R. W., Richards, A. M., & Cameron, V. A. (2012). Association between endothelin type A receptor haplotypes and mortality in coronary heart disease. Personalized Medicine, 9(3), 341-349. doi: 10.2217/PME.12.10

Ellis, K. L., Pilbrow, A. P., Frampton, C. M., Doughty, R. N., Whalley, G. A., Ellis, C. J., Palmer, B. R., Skelton, L., Yandle, T. G., Palmer, S. C., Troughton, R. W., Richards, A. M., & Cameron, V. A. (2010). A common variant at chromosome 9P21.3 is associated with age of onset of coronary disease but not subsequent mortality. Circulation: Cardiovascular Genetics, 3(3), 286-293. doi: 10.1161/circgenetics.109.917443

Jarvis, M. D., Palmer, B. R., Pilbrow, A. P., Ellis, K. L., Frampton, C. M., Skelton, L., … Whalley, G. A., … Yandle, T. G., Richards, A. M., & Cameron, V. A. (2010). CYP1A1 MSPI (T6235C) gene polymorphism is associated with mortality in acute coronary syndrome patients. Clinical & Experimental Pharmacology & Physiology, 37(2), 193-198. doi: 10.1111/j.1440-1681.2009.05261.x

Palmer, B. R., Devereaux, C. L., Dhamrait, S. S., Mocatta, T. J., Pilbrow, A. P., Frampton, C. M., Skelton, L., Yandle, T. G., Winterbourn, C. C., Richards, A. M., … Cameron, V. A. (2009). The common G-866A polymorphism of the UCP2 gene and survival in diabetic patients following myocardial infarction. Cardiovascular Diabetology, 8. doi: 10.1186/1475-2840-8-31

Palmer, B. R., Pilbrow, A. P., Frampton, C. M., Yandle, T. G., Skelton, L., Nicholls, M. G., & Richards, A. M. (2008). Plasma aldosterone levels during hospitalization are predictive of survival post-myocardial infarction. European Heart Journal, 29, 2489-2496. doi: 10.1093/eurheartj/ehn383

Palmer, B. R., Jarvis, M. D., Pilbrow, A. P., Ellis, K. L., Frampton, C. M., Skelton, L., Yandle, T. G., … Whalley, G. A., … Troughton, R. W., Richards, A. M., & Cameron, V. A. (2008). Angiotensin-converting enzyme 2 A1075G polymorphism is associated with survival in an acute coronary syndromes cohort. American Heart Journal, 156(4), 752-758. doi: 10.1016/j.ahj.2008.06.013

Littlejohn, M. D., Palmer, B. R., Richards, A. M., Frampton, C. M., Pilbrow, A. P., Troughton, R. W., Cameron, V. A., & Kennedy, M. A. (2008). Ile164 variant of β2-adrenoceptor does not influence outcome in heart failure but may interact with β blocker treatment. European Journal of Heart Failure, 10(1), 55-59. doi: 10.1016/j.ejheart.2007.10.011

Baird, T. E., Palmer, B. R., Frampton, C. M., Yandle, T. G., Skelton, L., Richards, A. M., & Cameron, V. A. (2007). Association of the aldosterone synthase gene C-344T polymorphism with risk factors and survival in a post-myocardial infarction cohort. Journal of Human Hypertension, 21, 256-258.

Pilbrow, A. P., Palmer, B. R., Frampton, C. M., Yandle, T. G., Troughton, R. W., Campbell, E., Skelton, L., Lainchbury, J. G., Richards, A. M., & Cameron, V. A. (2007). Angiotensinogen M235T and T174M gene polymorphisms in combination doubles the risk of mortality in heart failure. Hypertension, 49(2), 322-327.

Jarvis, M. D., Rademaker, M. T., Ellmers, L. J., Currie, M. J., McKenzie, J. L., Palmer, B. R., Frampton, C. M., Richards, A. M., & Cameron, V. A. (2006). Comparison of infarct-derived and control ovine cardiac myofibroblasts in culture: Response to cytokines and natriuretic peptide receptor expression profiles. American Journal of Physiology: Heart & Circulatory Physiology, 291, H1952-H1958. doi: 10.1152/ajpheart.00764.2005

Collins, R. P., Palmer, B. R., Pilbrow, A. P., Frampton, C. M., Troughton, R. W., Yandle, T. G., Skelton, L., Richards, A. M., & Cameron, V. A. (2006). Evaluation of AMPD1 C34T genotype as a predictor of mortality in heart failure and post-myocardial infarction patients. American Heart Journal, 152(2), 312-320.

Palmer, B. R., Pilbrow, A. P., Yandle, T. G., Frampton, C. M., Richards, A. M., Nicholls, M. G., & Cameron, V. A. (2003). Angiotensin-converting enzyme gene polymorphism interacts with left ventricular ejection fraction and brain natriuretic peptide levels to predict mortality after myocardial infarction. JACC, 41(5), 729-736. doi: 10.1016/S0735-1097(02)02927-3

Cameron, V. A., & Palmer, B. R. (2003). Reply to letter to the editor Angiotensin-converting enzyme polymorphism (I/D) and coronary heart disease in young adults. JACC, 42(10), 1864.

Ilian, M. A., Morton, J. D., Bekhit, A. E.-D., Roberts, N., Palmer, B. R., Sorimachi, H., & Bickerstaffe, R. (2001). Effect of preslaughter feed withdrawal period on longissimus tenderness and the expression of calpains in the ovine. Journal of Agricultural & Food Chemistry, 49(4), 1990-1998.

Su, H.-Y., Palmer, B. R., Wellby, M. P., Bickerstaffe, R., & Hickford, J. G. H. (2001). Differential expression of a gene homologous to a G-α protein gene in neonatal mouse skin during development of hair follicles. Journal of Dermatological Science, 25(1), 10-19.

Palmer, B. R., Su, H.-Y., Roberts, N., Hickford, J. G. H., & Bickerstaffe, R. (2000). Single nucleotide polymorphisms in an intron of the ovine calpastatin gene. Animal Biotechnology, 11(1), 63-67.

Palmer, B. R., Roberts, N., Hickford, J. G. H., & Bickerstaffe, R. (1998). PCR-RFLPs for MspI and NcoI in the ovine calpastatin gene. Journal of Animal Science, 76, 1499-1500.

Wu, R., Palmer, B. R., & Cole, A. L. J. (1998). Phenotypic variation and survival of genetically marked Pseudomonas tolaasii in mushroom compost. Canadian Journal of Microbiology, 44(4), 373-377.

Palmer, B. R., & Marinus, M. G. (1994). The dam and dcm strains of Escherichia coli: A review. Gene, 143(1), 1-12.

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Journal - Research Other

Stoner, L., Shultz, S. P., Lambrick, D. M., Krebs, J., Weatherall, M., Palmer, B. R., … Williams, M. A. (2013). The Combating Obesity in Māori and Pasifika Adolescent School-children Study: COMPASS methodology and study protocol. International Journal of Preventive Medicine, 4(5), 565-579. [Protocol/Methodology].

Palmer, B. R., Frampton, C. M., Richards, A. M., & Cameron, V. A. (2007). AMPD1 gene polymorphism and survival in patients with stable congestive heart failure [Letter to the editor]. American Heart Journal, 153, e13. Retrieved from http://www.sciencedirect.com/science?_ob=PublicationURL&_tockey=%23TOC%236683%232007%23998469994%23650294%23FLA%23&_cdi=6683&_pubType=J&_auth=y&_acct=C000007718&_version=1&_urlVersion=0&_userid=100241&md5=724a2d0db54e3f555bbfcbe8269e42c5

Palmer, B. R., Frampton, C. M., Richards, A. M., Cameron, V. A., & Nakayama, T. (2004). Absence of a NPR-A gene functional deletion allele in a postmyocardial infarction cohort from New Zealand [Letter to the editor]. Circulation Research, 94(10), e86.

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Journal - Professional & Other Non-Research Articles

Palmer, B. (2004). Australasian Biospecimens Network Annual Meeting. New Zealand BioScience, 13(1), 14-15.

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Conference Contribution - Published proceedings: Full paper

Palmer, B. R. (2004). Biotechnology in New Zealand: Diverse applications from adding value to primary produce to new tools for patient risk stratification. Proceedings of the International Symposium on Future Development of Agricultural Biotechnology Park. 1, (pp. 25-36). [Full Paper]

Palmer, B. R., & Su, H.-Y. (2004). Insulin-like growth factor 1 and hair growth. Proceedings of the International Symposium on Future Development of Agricultural Biotechnology Park. 1, (pp. 580-592). Taiwan: National Pintung University of Science and Technology. [Full Paper]

Palmer, B. R., Morton, J. D., Roberts, N., Ilian, M. A., & Bickerstaffe, R. (1999). Marker-assisted selection for meat quality and the ovine calpastatin gene. Proceedings of the New Zealand Society of Animal Production. 59, (pp. 266-268). [Full Paper]

Palmer, B. R., Hickford, J. G. H., & Bickerstaffe, R. (1997). A candidate gene approach to animal quality traits. Proceedings of the New Zealand Sociey of Animal Production. 57, (pp. 294-296). [Full Paper]

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Conference Contribution - Published proceedings: Abstract

Cameron, V. A., Pilbrow, A. P., Ellis, K. L., Palmer, B. R., Troughton, R. W., & Richards, A. M. (2014). Duelling hormones: The renin-aldosterone system versus the natriuretic peptides in heart disease. Proceedings of the Medical Sciences Congress (MedSci). (pp. 15). Retrieved from http://www.physoc.org.nz/meetings/archive/medsci-2014-abstracts

Palmer, B. (2010). Cardiovascular pharmacogenetics: Gems or junk. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Annual Scientific Meeting and the 6th Annual Carney Pharmacogenomics Symposium. ASCEPT. Retrieved from http://www.ascept.org.nz/

Cameron, V. A., Pilbrow, A. P., Palmer, B. R., Ellis, K. L., Pearson, J., Moravec, C. S., … Troughton, R. W., & Richards, A. M. (2009). Gene polymorphisms in patients with heart failure and acute coronary syndromes. CVD Prevention and Control. 4(Suppl. 1), (pp. S15). [Abstract]

Ellis, K. L., Pilbrow, A. P., Palmer, B. R., Frampton, C. M., Doughty, R. N., Ellis, C. J., Yandle, T. G., Troughton, R. W., Richards, A. M., & Cameron, V. A. (2009). A common variant at chromosome 9p21.3 is associated with age of onset of coronary disease but not subsequent mortality in coronary disease cohorts. European Heart Journal. 30(Suppl. 1), (pp. 63-64). doi: 10.1093/eurheartj/ehp416

Palmer, B. R., Ellis, K. L., Pilbrow, A. P., Skelton, L., Frampton, C. M., Troughton, R. W., Yandle, T. G., … Richards, A. M., & Cameron, V. A. (2009). Genetic polymorphism rs6922269 from the MTHFD1L gene predicts survival in patients after acute coronary syndromes. Proceedings of the ComBio2009 Conference. [CD-ROM] [Abstract]

Ellis, K. L., Pilbrow, A. P., Skelton, L., Frampton, C. M., Yandle, T. G., Palmer, B. R., Gemmell, N. J., Richards, A. M., & Cameron, V. A. (2008). Prognostic neurohormone levels in acute coronary syndromes patients of New Zealand European, Maori and Pacific ancestry. New Zealand Medical Journal, 121(1271). Retrieved from http://journal.nzma.org.nz/journal/121-1271/2990/content.pdf

Palmer, B. R., Jarvis, M. D., Pilbrow, A. P., Ellis, K. L., Frampton, C. M., Skelton, L., Yandle, T. G., … Troughton, R. W., Richards, A. M., & Cameron, V. A. (2008). Angiotensin-converting enzyme 2 gene variants and survival in an acute coronary syndromes cohort. New Zealand Medical Journal, 121(1271). Retrieved from http://journal.nzma.org.nz/journal/121-1271/2990/content.pdf

Palmer, B. R., Jarvis, M. D., Pilbrow, A. P., Frampton, C. M., Skelton, L., Littlejohn, M. D., Kennedy, M. A., … Yandle, T. G., Richards, A. M., & Cameron, V. A. (2008). Cardiovascular pharmacogenetics: Taking the opportunities. Proceedings of the 4th Annual Carney Pharmacogenomics Symposium. Retrieved from http://www.chmeds.ac.nz/research/carneycentre/symposium.htm

Palmer, B. R., Pilbrow, A. P., Skelton, L., Ellis, K. L., Jarvis, M. D., Frampton, C. M., Yandle, T. G., Richards, A. M., & Cameron, V. A. (2008). ACE gene polymorphisms, survival and natriuretic peptide profiles after acute coronary syndromes. Arquivos Brasileiros de Endocrinologia & Metabologia. (pp. S895-S896). [Abstract]

Ellis, K. L., Pilbrow, A. P., Skelton, L. Z., Frampton, C. M., Yandle, T. G., Palmer, B. R., Gemmell, N. J., Richards, A. M., & Cameron, V. A. (2007). Prognostic neurohormone levels in acute coronary syndromes patients of New Zealand European, Maori and Pacific ancestry. European Heart Journal. 28(Abstract Suppl.), (pp. 771). [Abstract]

Palmer, B. R., Robinson, J., Skelton, L., Frampton, C. M., Pilbrow, A. P., Troughton, R. W., Yandle, T. G., Richards, M., & Cameron, V. A. (2006). The Christchurch Cardioendocrine Research Group DNA Bank: Seeking improved prognostic markers for heart disease patients. Proceedings of the Australian Health and Medical Research Congress. (pp. 389). Sydney, Australia: Australian Health and Medical Research Congress. [Abstract]

Palmer, B. R., Baird, T. E., Collins, R. P., Pilbrow, A. P., Skelton, L., Frampton, C. M., Yandle, T. G., Richards, A. M., & Cameron, V. A. (2006). Genetic polymorphisms as predictors of clinical outcome after acute myocardial infarction. New Zealand Medical Journal, 119(1231). Retrieved from http://journal.nzma.org.nz/journal/119-1231/1922/content.pdf

Pilbrow, A. P., Palmer, B. R., Frampton, C. M., Yandle, T. G., Troughton, R. W., Campbell, E., Skelton, L., Lainchbury, J. G., Richards, A. M., & Cameron, V. A. (2006). Association of angiotensinogen M235T and T174M gene polymorphisms with mortality in heart failure. New Zealand Medical Journal, 119(1231). Retrieved from http://journal.nzma.org.nz/journal/119-1231/1922/content.pdf

Cameron, V. A., Pilbrow, A. P., Palmer, B. R., Mocatta, T. J., Frampton, C. M., Troughton, R. W., Richards, A. M., & Winterbourn, C. C. (2006). Oxidative stress levels in human heart disease are correlated with angiotensin type-1 receptor A1166C gene polymorphism. Proceedings of the New Zealand Society of Endocrinology Annual Meeting. NZSE. Retrieved from http://nzse.rsnz.org/NZSE%20Abstracts%202006.pdf

Palmer, B. R., Baird, T. E., Yandle, T. G., Skelton, L., Richards, A. M., & Cameron, V. A. (2005). The aldosterone synthase gene (CYP11B2) C-344T polymorphism is associated with brain natriuretic peptide level and survival in a post-myocardial infarction cohort. Proceedings of the New Zealand Society for Biochemistry and Molecular Biology and the New Zealand Microbiological Society Annual Conference. (pp. 110). [Abstract]

Pilbrow, A. P., Palmer, B. R., Frampton, C. M., Yandle, T. G., Troughton, R. W., Campbell, E., Skelton, L., Lainchbury, J. G., Richards, A. M., & Cameron, V. A. (2005). The genetics of coronary heart disease. Proceedings of the Human Genetics Society of Australasia (NZ Branch) Biennial Scientific Meeting and Annual General Meeting. [Abstract]

Pilbrow, A. P., Palmer, B. R., Frampton, C. M., Yandle, T. G., Troughton, R. W., Campbell, E., Skelton, L., Lainchbury, J. G., Richards, A. M., & Cameron, V. A. (2005). Association of angiotensinogen M235T and T174M gene polymorphisms with mortality in heart failure. Proceedings of the Canterbury Health Research Conference. (pp. 23). [Abstract]

Palmer, B. R., Baird, T. E., Collins, R. P., Pilbrow, A. P., Skelton, L., Frampton, C. M., Yandle, T. G., Richards, A. M., & Cameron, V. A. (2005). Genetic polymorphisms as predictors of clinical outcome after acute myocardial infarction. Proceedings of the Canterbury Health Research Conference. (pp. 20). [Abstract]

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