Ahorangi Rangahau (Research Professor) John Pickering joined the Department of Medicine in 2007, initially to study how to better diagnose and tread kidney failure in the intensive care. Now, he is a kaipūtaiao (scientist) and kaitātara koiora (biostatistician) with the Rangahau Manawa o Ōtautahi (Christchurch Heart Institute) and Big Data and Ageing research groups of University of Ōtago Christchurch, and the Emergency medicine research group of Christchurch Hospital. His interests include optimising the use of biomarkers for diagnosis, clinical pathway development and translational research in acute care, and using the interRAI data to improve the well-being of older persons.
He comes from a physics background and was once part of the team that pioneered the use of lasers to remove birthmarks.
Publications
Jamieson, H., Nishtala, P. S., Bergler, H. U., Weaver, S. K., Pickering, J. W., Ailabouni, N. J., Abey-Nesbit, R., … Mangin, D. (2023). Deprescribing anticholinergic and sedative drugs to reduce polypharmacy in frail older adults living in the community: A randomized controlled trial. Journals of Gerontology Series A, glac249. Advance online publication. doi: 10.1093/gerona/glac249
Miller, R., Nixon, G., Stokes, T., Smith, M., Pickering, J. W., Liepins, T., & Than, M. (2022). The cost-savings of the rural accelerated chest pain pathway for low-risk chest pain in rural general practice: A cost minimisation analysis. Journal of Primary Health Care. Advance online publication. doi: 10.1071/HC22117
Addy, K., Joyce, L., Al-Busaidi, I. S., Pickering, J. W., Troughton, R., & Than, M. (2022, November). Improvement in patient outcomes following implementation of an emergency department atrial fibrillation pathway using a 'rate-and-wait' approach. Poster session presented at the Australasian College for Emergency Medicine (ACEM) Spring Symposium, Christchurch, New Zealand.
Pickering, J. W., Scrase, R., Troughton, R., & Jamieson, H. A. (2022). Evaluation of the added value of Brain Natriuretic Peptide to a validated mortality risk-prediction model in older people using a standardised international clinical assessment tool. PLoS ONE, 17(11), e0277850. doi: 10.1371/journal.pone.0277850
Huang, X., Li, Y., Fowler, C., Doecke, J. D., Lim, Y. Y., Drysdale, C., … Pickering, J. W., … Gu, B. J. (2022). Leukocyte surface biomarkers implicate deficits of innate immunity in sporadic Alzheimer's disease. Alzheimer's & Dementia. Advance online publication. doi: 10.1002/alz.12813
Pickering, J. W., & Endre, Z. H. (2012). The metamorphosis of acute renal failure to acute kidney injury. In M. Sahay (Ed.), Basic nephrology and acute kidney injury. (pp. 125-150). Rijeka, Croatia: InTech. doi: 10.5772/1298
Chapter in Book - Research
Pickering, J. W. (2008). Plagiarism. In V. N. Parrillo (Ed.), Encyclopedia of social problems (Vol. 2). (pp. 664-667). Thousand Oaks, CA: SAGE.
Chapter in Book - Research
McGrath, T., Butcher, A., Koo, Y., Pickering, J., & Smith, H. (2007). Engaging Asian communities in Aotearoa New Zealand: An exploration of what works in community research. In A. Williamson & R. DeSouza (Eds.), Researching with communities: Grounded perspectives on engaging communities in research. (pp. 385-398). Auckland, New Zealand: Muddy Creek Press.
Chapter in Book - Research
Leong, F. T. L., Zhang, H., Pickering, J., & Chang, J. (2008). Family and home country influences on adjustment (Case Incident 7: Responses). In N. Arthur & P. Pedersen (Eds.), Case incidents in counseling for international transitions. (pp. 99-112). Alexandria, VA: American Counseling Association.
Chapter in Book - Other
Jamieson, H., Nishtala, P. S., Bergler, H. U., Weaver, S. K., Pickering, J. W., Ailabouni, N. J., Abey-Nesbit, R., … Mangin, D. (2023). Deprescribing anticholinergic and sedative drugs to reduce polypharmacy in frail older adults living in the community: A randomized controlled trial. Journals of Gerontology Series A, glac249. Advance online publication. doi: 10.1093/gerona/glac249
Journal - Research Article
Abey-Nesbit, R., Bergler, U., Pickering, J. W., Nishtala, P. S., & Jamieson, H. (2022). Development and validation of a frailty index compatible with three interRAI assessment instruments. Age & Ageing, 51, afac178. doi: 10.1093/ageing/afac178
Journal - Research Article
Doudesis, D., Lee, K. K., Yang, J., Wereski, R., Shah, A. S. V., Tsanas, A., … Pickering, J. W., … on behalf of the High-STEACS Investigators. (2022). Validation of the myocardial-ischaemic-injury-index machine learning algorithm to guide the diagnosis of myocardial infarction in a heterogenous population: A prespecified exploratory analysis. Lancet Digital Health, 4, e300-e308. doi: 10.1016/s2589-7500(22)00025-5
Journal - Research Article
Huang, X., Li, Y., Fowler, C., Doecke, J. D., Lim, Y. Y., Drysdale, C., … Pickering, J. W., … Gu, B. J. (2022). Leukocyte surface biomarkers implicate deficits of innate immunity in sporadic Alzheimer's disease. Alzheimer's & Dementia. Advance online publication. doi: 10.1002/alz.12813
Journal - Research Article
Miller, R., Nixon, G., Pickering, J. W., Stokes, T., Turner, R. M., Young, J., Gutenstein, M., Smith, M., … Watson, A., George, P., … Than, M. (2022). A prospective multi-centre study assessing the safety and effectiveness following the implementation of an accelerated chest pain pathway using point-of-care troponin for use in New Zealand rural hospital and primary care settings. European Heart Journal: Acute Cardiovascular Care. Advance online publication. doi: 10.1093/ehjacc/zuac037
Journal - Research Article
Miller, R., Nixon, G., Stokes, T., Smith, M., Pickering, J. W., Liepins, T., & Than, M. (2022). The cost-savings of the rural accelerated chest pain pathway for low-risk chest pain in rural general practice: A cost minimisation analysis. Journal of Primary Health Care. Advance online publication. doi: 10.1071/HC22117
Journal - Research Article
Norman, T., Young, J., Jones, J. S., Egan, G., Pickering, J., Du Toit, S., … Miller, R., Frampton, C., … George, P., & Than, M. (2022). Implementation and evaluation of a rural general practice assessment pathway for possible cardiac chest pain using point-of-care troponin testing: A pilot study. BMJ Open, 12, e044801. doi: 10.1136/bmjopen-2020-044801
Journal - Research Article
Pickering, J. W., Scrase, R., Troughton, R., & Jamieson, H. A. (2022). Evaluation of the added value of Brain Natriuretic Peptide to a validated mortality risk-prediction model in older people using a standardised international clinical assessment tool. PLoS ONE, 17(11), e0277850. doi: 10.1371/journal.pone.0277850
Journal - Research Article
Templeton, E. M., Lassé, M., Kleffmann, T., Ellmers, L. J., Palmer, S. C., Davidson, T., Scott, N. J. A., Pickering, J. W., Charles, C. J., Endre, Z. H., Cameron, V. A., Richards, A. M., Rademaker, M. T., & Pilbrow, A. P. (2022). Identifying candidate protein markers of acute kidney injury in acute decompensated heart failure. International Journal of Molecular Sciences, 23, 1009. doi: 10.3390/ijms23021009
Journal - Research Article
Abey-Nesbit, R., Peel, N. M., Matthews, H., Hubbard, R. E., Nishtala, P. S., Bergler, U., Deely, J. M., Pickering, J. W., Schluter, P. J., & Jamieson, H. A. (2021). Frailty of Māori, Pasifika, and non-Māori/non-Pasifika older people in New Zealand: A national population study of older people referred for home care services. Journals of Gerontology Series A, 76(6), 1101-1107. doi: 10.1093/gerona/glaa265
Journal - Research Article
Heidari, K., Arani, M. A., Sheibani, M., Pickering, J. W., & Chouhdari, A. (2021). Comparison of two diagnostic protocols in the management of possible cardiac chest pain: One follow-up study in Iran. Caspian Journal of Internal Medicine, 12(2), 148-154. doi: 10.22088/cjim.12.2.148
Journal - Research Article
Lamba, M., Pickering, J. W., Than, M., Iles, S., & Beckert, L. (2021). Long-term outcomes in patients with pulmonary embolism: Results from a longitudinal cohort study. Internal Medicine Journal, 51, 699-704. doi: 10.1111/imj.14409
Journal - Research Article
Templeton, E. M., Cameron, V. A., Pickering, J. W., Richards, A. M., & Pilbrow, A. P. (2021). Emerging microRNA biomarkers for acute kidney injury in acute decompensated heart failure. Heart Failure Reviews, 26, 1203-1217. doi: 10.1007/s10741-020-09928-w
Journal - Research Article
Than, M. P., Pickering, J. W., Adamson, P., Clendon, T., Florkowski, C. M., Lainchbury, J., Loubser, J., … Aldous, S. J. (2021). Reducing patient risk and enhancing care through the development and implementation of a new chest pain pathway, expedited by and for the COVID-19 era. eJIFCC, 32(1), 27-40.
Journal - Research Article
Villacorta, H., Pickering, J. W., Horiuchi, Y., Olim, M., Coyne, C., Maisel, A. S., & Than, M. P. (2021). Machine learning with D-dimer in the risk stratification for pulmonary embolism: A derivation and internal validation study. European Heart Journal: Acute Cardiovascular Care. Advance online publication. doi: 10.1093/ehjacc/zuab089
Journal - Research Article
Vincent, A., Pearson, S., Pickering, J. W., Weaver, J., Toney, L., Hamill, L., Hurrell, M., & Than, M. (2021). Sensitivity of modern multislice CT for subarachnoid haemorrhage at incremental timepoints after headache onset: A 10-year analysis. Emergency Medicine Journal. Advance online publication. doi: 10.1136/emermed-2020-211068
Journal - Research Article
Albert, C., Zapf, A., Haase, M., Röver, C., Pickering, J. W., Albert, A., … Haase-Fielitz, A. (2020). Neutrophil gelatinase-associated lipocalin measured on clinical laboratory platforms for the prediction of acute kidney injury and the associated need for dialysis therapy: A systematic review and meta-analysis. American Journal of Kidney Diseases, 76(6), 826-841. doi: 10.1053/j.ajkd.2020.05.015
Journal - Research Article
Burnside, M., Crocket, H., Mayo, M., Pickering, J., Tappe, A., & de Bock, M. (2020). Do-it-yourself automated insulin delivery: A leading example of the democratization of medicine. Journal of Diabetes Science & Technology, 14(5), 878-882. doi: 10.1177/1932296819890623
Journal - Research Article
Chan, M. Y., Efthymios, M., Tan, S. H., Pickering, J. W., Troughton, R., Pemberton, C., … Pilbrow, A., & Richards, A. M. (2020). Prioritizing candidates of post-myocardial infarction heart failure using plasma proteomics and single-cell transcriptomics. Circulation, 142, 1408-1421. doi: 10.1161/circulationaha.119.045158
Journal - Research Article
Chiew, A. L., James, L. P., Isbister, G. K., Pickering, J. W., McArdle, K., Chan, B. S. H., & Buckley, N. A. (2020). Early acetaminophen-protein adducts predict hepatotoxicity following overdose (ATOM-5). Journal of Hepatology, 72, 450-462. doi: 10.1016/j.jhep.2019.10.030
Journal - Research Article
Diefenhardt, P., Pickering, J. W., & Heine, G. H. (2020). Erlaubt eine Bestimmung von FGF23 bei chronisch nierenkranken Menschen eine verbesserte Vorhersage renaler und kardiovaskulärer Ereignisse? [Does a determination of FGF23 in chronic kidney disease allow improved prediction of renal and cardiovascular events?]. Der Nephrologe, 15, 112-113. doi: 10.1007/s11560-019-00399-1
Journal - Research Article
Greenslade, J. H., Sieben, N., Parsonage, W. A., Knowlman, T., Ruane, L., Than, M., Pickering, J. W., … Cullen, L. (2020). Factors influencing physician risk estimates for acute cardiac events in emergency patients with suspected acute coronary syndrome. Emergency Medicine Journal, 37, 2-7. doi: 10.1136/emermed-2019-208916
Journal - Research Article
Hertzberg, D. P., Luksha, Y., Kus, I., Eslampia, P., Pickering, J. W., & Holzmann, M. J. (2020). Gait speed at discharge and risk for readmission or death: A prospective study of an emergency ward population. Open Access Emergency Medicine, 12, 127-135. doi: 10.2147/OAEM.S229479
Journal - Research Article
Jamieson, H. A., Abey-Nesbit, R., & Pickering, J. W. (2020). Effect of capacity to undertake instrumental activities of daily living on entry to aged residential care in older people with heart failure. Frontiers in Medicine, 7, 386. doi: 10.3389/fmed.2020.00386
Journal - Research Article
Jamieson, H., Abey-Nesbit, R., Nishtala, P. S., Allore, H., Han, L., Deely, J. M., & Pickering, J. W. (2020). Predictors of residential care admission in community-dwelling older people with dementia. Journal of the American Medical Directors Association, 21(11), 1665-1670. doi: 10.1016/j.jamda.2020.04.021
Journal - Research Article
Pickering, J. W., Abey-Nesbit, R., Allore, H., & Jamieson, H. (2020). Development and validation of multivariable mortality risk-prediction models in older people undergoing an interRAI home-care assessment (RiskOP). eClinicalMedicine, 29-30, 100614. doi: 10.1016/j.eclinm.2020.100614
Journal - Research Article
Pickering, J. W., Young, J. M., George, P. M., Pemberton, C. J., Watson, A., Aldous, S. J., … Troughton, R. W., Richards, A. M., … Than, M. P. (2020). Early kinetic profiles of troponin I and T measured by high-sensitivity assays in patients with myocardial infarction. Clinica Chimica Acta, 505, 15-25. doi: 10.1016/j.cca.2020.02.009
Journal - Research Article
Sanchis, J., Valero, E., Blas, S. G., Barba, E., Pernias, V., Miñana, G., … Pickering, J. W. (2020). Undetectable high-sensitivity troponin in combination with clinical assessment for risk stratification of patients with chest pain and normal troponin at hospital arrival. European Heart Journal: Acute Cardiovascular Care, 9(6), 567-575. doi: 10.1177/2048872620907539
Journal - Research Article
Adamson, P. D., McAllister, D., Pilbrow, A., Pickering, J. W., Poppe, K., Shah, A., Whalley, G., … Pemberton, C., Troughton, R. W., … Richards, A. M. (2019). Convalescent troponin and cardiovascular death following acute coronary syndrome. Heart, 105, 1717-1724. doi: 10.1136/heartjnl-2019-315084
Journal - Research Article
Gutenstein, M., Pickering, J. W., & Than, M. (2019). Development of a digital clinical pathway for emergency medicine: Lessons from usability testing and implementation failure. Health Informatics Journal, 25(4), 1563-1571. doi: 10.1177/1460458218779099
Journal - Research Article
Hertzberg, D. P., Sartipy, U., Lund, L. H., Rydén, L., Pickering, J. W., & Holzmann, M. J. (2019). Heart failure and the risk of acute kidney injury in relation to ejection fraction in patients undergoing coronary artery bypass grafting. International Journal of Cardiology, 274, 66-70. doi: 10.1016/j.ijcard.2018.09.092
Journal - Research Article
Hertzberg, D., Holzmann, M. J., Than, M., & Pickering, J. W. (2019). Acute kidney injury in patients presenting with chest pain to the emergency department: A descriptive study of the most common discharge diagnoses and mortality. European Journal of Emergency Medicine, 26(4), 242-248. doi: 10.1097/mej.0000000000000552
Journal - Research Article
Nestelberger, T., Cullen, L., Lindahl, B., Reichlin, T., Greenslade, J. H., Giannitsis, E., … Pickering, J. W., Than, M., on behalf of the APACE, ADAPT and TRAPID-AMI Investigators. (2019). Diagnosis of acute myocardial infarction in the presence of left bundle branch block. Heart, 105, 1559-1567. doi: 10.1136/heartjnl-2018-314673
Journal - Research Article
Neumann, J. T., Twerenbold, R., Ojeda, F., Sörensen, N. A., Chapman, A. R., Shah, A. S. V., … Pickering, J. W., Troughton, R. W., … Than, M., … Blankenberg, S. (2019). Application of high-sensitivity troponin in suspected myocardial infarction. New England Journal of Medicine, 380(26), 2529-2540. doi: 10.1056/NEJMoa1803377
Journal - Research Article
Than, M. P., Pickering, J. W., Sandoval, Y., Shah, A. S. V., Tsanas, A., Apple, F. S., … on behalf of the MI3 Collaborative. (2019). Machine learning to predict the likelihood of acute myocardial infarction. Circulation, 140, 899-909. doi: 10.1161/circulationaha.119.041980
Journal - Research Article
Carlton, E. W., Pickering, J. W., Greenslade, J., Cullen, L., Than, M., Kendall, J., … Greaves, K. (2018). Assessment of the 2016 National Institute for Health and Care Excellence high-sensitivity troponin rule-out strategy. Heart, 104(8), 665-672. doi: 10.1136/heartjnl-2017-311983
Journal - Research Article
Farnaz, B., Payman, I., Mohammad, R., Pickering, J. W., & Seyed-Mostafa, H.-Z. (2018). Incidence of non-alcoholic fatty liver disease among referral outpatients to the internal medicine clinic. Asian Journal of Pharmaceutics, 12(Suppl. 1), S323-S327. doi: 10.22377/ajp.v12i01
Journal - Research Article
Greenslade, J. H., Chung, K., Parsonage, W. A., Hawkins, T., Than, M., Pickering, J. W., & Cullen, L. (2018). Modification of the Thrombolysis in Myocardial Infarction risk score for patients presenting with chest pain to the emergency department. Emergency Medicine Australasia, 30(1), 47-54. doi: 10.1111/1742-6723.12913
Journal - Research Article
Kavsak, P. A., Neumann, J. T., Cullen, L., Than, M., Shortt, C., Greenslade, J. H., Pickering, J. W., … Troughton, R., … Worster, A. (2018). Clinical chemistry score versus high-sensitivity cardiac troponin I and T tests alone to identify patients at low or high risk for myocardial infarction or death at presentation to the emergency department. CMAJ, 190(33), E974-E984. doi: 10.1503/cmaj.180144
Journal - Research Article
McIlroy, D. R., Farkas, D., Pan, K., Pickering, J. W., & Lee, H. T. (2018). Combining novel renal injury markers with delta serum creatinine early after cardiac surgery and risk-stratification for serious adverse outcomes: An exploratory analysis. Journal of Cardiothoracic & Vascular Anesthesia, 32(5), 2190-2200. doi: 10.1053/j.jvca.2017.12.052
Journal - Research Article
Pickering, J. W., Blunt, I. R. H., & Than, M. P. (2018). Acute kidney injury and mortality prognosis in acute coronary syndrome patients: A meta-analysis. Nephrology, 23(3), 237-246. doi: 10.1111/nep.12984
Journal - Research Article
Pickering, J. W., Flaws, D., Smith, S. W., Greenslade, J., Cullen, L., Parsonage, W., … Richards, A. M., Troughton, R., Pemberton, C., George, P. M., & Than, M. P. (2018). A risk assessment score and initial high-sensitivity troponin combine to identify low risk of acute myocardial infarction in the emergency department. Academic Emergency Medicine, 25(4), 434-443. doi: 10.1111/acem.13343
Journal - Research Article
Pickering, J. W., Young, J. M., George, P. M., Watson, A. S., Aldous, S. J., Troughton, R. W., Pemberton, C. J., Richards, A. M., … Than, M. P. (2018). Validity of a novel point-of-care troponin assay for single-test rule-out of acute myocardial infarction. JAMA Cardiology, 3(11), 1108-1112. doi: 10.1001/jamacardio.2018.3368
Journal - Research Article
Seiler-Mussler, S., Limbach, A. S., Emrich, I. E., Pickering, J. W., Roth, H. J., Fliser, D., & Heine, G. H. (2018). Association of nonoxidized parathyroid hormone with cardiovascular and kidney disease outcomes in chronic kidney disease. Clinical Journal of the American Society of Nephrology, 13(4), 569-576. doi: 10.2215/cjn.06620617
Journal - Research Article
Than, M. P., Aldous, S. J., Troughton, R. W., Pemberton, C. J., Richards, A. M., Frampton, C. M. A., Florkowski, C. M., George, P. M., … Young, J. M., … Pickering, J. W. (2018). Detectable high-sensitivity cardiac troponin within the population reference interval conveys high 5-year cardiovascular risk: An observational study. Clinical Chemistry, 64(7), 1044-1053. doi: 10.1373/clinchem.2017.285700
Journal - Research Article
Than, M. P., Pickering, J. W., Dryden, J. M., Lord, S. J., Aitken, S. A., Aldous, S. J., … Ardagh, M. W., … Callender, R., … Deely, J. M., … Ferrier, K. A., … Frampton, C. M. A., George, P. M., … Matthews, T. J. E., … Peckler, B. F., … Richards, A. M., … Simmonds, M. B., … Troughton, R. W., … on behalf of the ICare-ACS Implementation Group. (2018). ICare-ACS (improving care processes for patients with suspected acute coronary syndrome): A study of cross-system implementation of a national clinical pathway. Circulation, 137(4), 354-363. doi: 10.1161/circulationaha.117.031984
Journal - Research Article