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Associate Professor John Pickering

Associate Professor

John Pickering

BSc(Hons) PhD BA(Hons)

Email john.pickering@otago.ac.nz

Associate Professor John Pickering joined the Department of Medicine in 2007 to study how to better diagnose kidney disease in intensive care.

More recently he has been part of the Christchurch Heart Institute. Since 2014 he has been involved in translational research in the Emergency Department. In particular as Research Director for the ED research team he has tested, developed and implemented diagnostic pathways to more quickly and safely rule-out a heart attack in people presenting to the Emergency Department with chest pain.

He comes from a physics background and was once part of the team that pioneered the use of lasers to remove birthmarks.

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Publications

Lamba, M., Pickering, J., Than, M., Iles, S., & Beckert, L. (2019). Long-term outcomes in patients with pulmonary embolism: Results from a longitudinal cohort study. Internal Medicine Journal. Advance online publication. doi: 10.1111/imj.14409

Neumann, J. T., Twerenbold, R., Ojeda, F., Sörensen, N. A., Chapman, A. R., Shah, A. S. V., … Pickering, J. W., Troughton, R. W., … Than, M., … Blankenberg, S. (2019). Application of high-sensitivity troponin in suspected myocardial infarction. New England Journal of Medicine, 380(26), 2529-2540. doi: 10.1056/NEJMoa1803377

Nestelberger, T., Cullen, L., Lindahl, B., Reichlin, T., Greenslade, J. H., Giannitsis, E., … Pickering, J. W., Than, M., on behalf of the APACE, ADAPT and TRAPID-AMI Investigators. (2019). Diagnosis of acute myocardial infarction in the presence of left bundle branch block. Heart. Advance online publication. doi: 10.1136/heartjnl-2018-314673

Pickering, J. W., Blunt, I. R. H., & Than, M. P. (2018). Acute kidney injury and mortality prognosis in acute coronary syndrome patients: A meta-analysis. Nephrology, 23(3), 237-246. doi: 10.1111/nep.12984

Pickering, J. W., Flaws, D., Smith, S. W., Greenslade, J., Cullen, L., Parsonage, W., … Richards, A. M., Troughton, R., Pemberton, C., George, P. M., & Than, M. P. (2018). A risk assessment score and initial high-sensitivity troponin combine to identify low risk of acute myocardial infarction in the emergency department. Academic Emergency Medicine, 25(4), 434-443. doi: 10.1111/acem.13343

Chapter in Book - Research

Pickering, J. W., & Endre, Z. H. (2012). The metamorphosis of acute renal failure to acute kidney injury. In M. Sahay (Ed.), Basic nephrology and acute kidney injury. (pp. 125-150). Rijeka, Croatia: InTech. doi: 10.5772/1298

Pickering, J. W. (2008). Plagiarism. In V. N. Parrillo (Ed.), Encyclopedia of social problems (Vol. 2). (pp. 664-667). Thousand Oaks, CA: SAGE.

McGrath, T., Butcher, A., Koo, Y., Pickering, J., & Smith, H. (2007). Engaging Asian communities in Aotearoa New Zealand: An exploration of what works in community research. In A. Williamson & R. DeSouza (Eds.), Researching with communities: Grounded perspectives on engaging communities in research. (pp. 385-398). Auckland, New Zealand: Muddy Creek Press.

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Chapter in Book - Other

Leong, F. T. L., Zhang, H., Pickering, J., & Chang, J. (2008). Family and home country influences on adjustment (Case Incident 7: Responses). In N. Arthur & P. Pedersen (Eds.), Case incidents in counseling for international transitions. (pp. 99-112). Alexandria, VA: American Counseling Association.

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Journal - Research Article

Lamba, M., Pickering, J., Than, M., Iles, S., & Beckert, L. (2019). Long-term outcomes in patients with pulmonary embolism: Results from a longitudinal cohort study. Internal Medicine Journal. Advance online publication. doi: 10.1111/imj.14409

Nestelberger, T., Cullen, L., Lindahl, B., Reichlin, T., Greenslade, J. H., Giannitsis, E., … Pickering, J. W., Than, M., on behalf of the APACE, ADAPT and TRAPID-AMI Investigators. (2019). Diagnosis of acute myocardial infarction in the presence of left bundle branch block. Heart. Advance online publication. doi: 10.1136/heartjnl-2018-314673

Neumann, J. T., Twerenbold, R., Ojeda, F., Sörensen, N. A., Chapman, A. R., Shah, A. S. V., … Pickering, J. W., Troughton, R. W., … Than, M., … Blankenberg, S. (2019). Application of high-sensitivity troponin in suspected myocardial infarction. New England Journal of Medicine, 380(26), 2529-2540. doi: 10.1056/NEJMoa1803377

Pickering, J. W., Blunt, I. R. H., & Than, M. P. (2018). Acute kidney injury and mortality prognosis in acute coronary syndrome patients: A meta-analysis. Nephrology, 23(3), 237-246. doi: 10.1111/nep.12984

Pickering, J. W., Flaws, D., Smith, S. W., Greenslade, J., Cullen, L., Parsonage, W., … Richards, A. M., Troughton, R., Pemberton, C., George, P. M., & Than, M. P. (2018). A risk assessment score and initial high-sensitivity troponin combine to identify low risk of acute myocardial infarction in the emergency department. Academic Emergency Medicine, 25(4), 434-443. doi: 10.1111/acem.13343

Greenslade, J. H., Chung, K., Parsonage, W. A., Hawkins, T., Than, M., Pickering, J. W., & Cullen, L. (2018). Modification of the Thrombolysis in Myocardial Infarction risk score for patients presenting with chest pain to the emergency department. Emergency Medicine Australasia, 30(1), 47-54. doi: 10.1111/1742-6723.12913

Than, M. P., Pickering, J. W., Dryden, J. M., Lord, S. J., Aitken, S. A., Aldous, S. J., … Ardagh, M. W., … Callender, R., … Deely, J. M., … Ferrier, K. A., … Frampton, C. M. A., George, P. M., … Matthews, T. J. E., … Peckler, B. F., … Richards, A. M., … Simmonds, M. B., … Troughton, R. W., … on behalf of the ICare-ACS Implementation Group. (2018). ICare-ACS (improving care processes for patients with suspected acute coronary syndrome): A study of cross-system implementation of a national clinical pathway. Circulation, 137(4), 354-363. doi: 10.1161/circulationaha.117.031984

Pickering, J. W., Young, J. M., George, P. M., Watson, A. S., Aldous, S. J., Troughton, R. W., Pemberton, C. J., Richards, A. M., … Than, M. P. (2018). Validity of a novel point-of-care troponin assay for single-test rule-out of acute myocardial infarction. JAMA Cardiology. Advance online publication. doi: 10.1001/jamacardio.2018.3368

Hertzberg, D., Holzmann, M. J., Than, M., & Pickering, J. W. (2018). Acute kidney injury in patients presenting with chest pain to the emergency department: A descriptive study of the most common discharge diagnoses and mortality. European Journal of Emergency Medicine. Advance online publication. doi: 10.1097/mej.0000000000000552

Seiler-Mussler, S., Limbach, A. S., Emrich, I. E., Pickering, J. W., Roth, H. J., Fliser, D., & Heine, G. H. (2018). Association of nonoxidized parathyroid hormone with cardiovascular and kidney disease outcomes in chronic kidney disease. Clinical Journal of the American Society of Nephrology, 13(4), 569-576. doi: 10.2215/cjn.06620617

Carlton, E. W., Pickering, J. W., Greenslade, J., Cullen, L., Than, M., Kendall, J., … Greaves, K. (2018). Assessment of the 2016 National Institute for Health and Care Excellence high-sensitivity troponin rule-out strategy. Heart, 104(8), 665-672. doi: 10.1136/heartjnl-2017-311983

McIlroy, D. R., Farkas, D., Pan, K., Pickering, J. W., & Lee, H. T. (2018). Combining novel renal injury markers with delta serum creatinine early after cardiac surgery and risk-stratification for serious adverse outcomes: An exploratory analysis. Journal of Cardiothoracic & Vascular Anesthesia, 32(5), 2190-2200. doi: 10.1053/j.jvca.2017.12.052

Hertzberg, D. P., Sartipy, U., Lund, L. H., Rydén, L., Pickering, J. W., & Holzmann, M. J. (2018). Heart failure and the risk of acute kidney injury in relation to ejection fraction in patients undergoing coronary artery bypass grafting. International Journal of Cardiology. Advance online publication. doi: 10.1016/j.ijcard.2018.09.092

van der Linden, N., Wildi, K., Twerenbold, R., Pickering, J. W., Than, M., Cullen, L., … Richards, A. M., Troughton, R., Pemberton, C., … Mueller, C. (2018). Combining high sensitivity cardiac troponin I and cardiac troponin T in the early diagnosis of acute myocardial infarction. Circulation. Advance online publication. doi: 10.1161/circulationaha.117.032003

Than, M. P., Aldous, S. J., Troughton, R. W., Pemberton, C. J., Richards, A. M., Frampton, C. M. A., Florkowski, C. M., George, P. M., … Young, J. M., … Pickering, J. W. (2018). Detectable high-sensitivity cardiac troponin within the population reference interval conveys high 5-year cardiovascular risk: An observational study. Clinical Chemistry, 64(7), 1044-1053. doi: 10.1373/clinchem.2017.285700

Farnaz, B., Payman, I., Mohammad, R., Pickering, J. W., & Seyed-Mostafa, H.-Z. (2018). Incidence of non-alcoholic fatty liver disease among referral outpatients to the internal medicine clinic. Asian Journal of Pharmaceutics, 12(Suppl. 1), S323-S327. doi: 10.22377/ajp.v12i01

Kavsak, P. A., Neumann, J. T., Cullen, L., Than, M., Shortt, C., Greenslade, J. H., Pickering, J. W., … Troughton, R., … Worster, A. (2018). Clinical chemistry score versus high-sensitivity cardiac troponin I and T tests alone to identify patients at low or high risk for myocardial infarction or death at presentation to the emergency department. CMAJ, 190(33), E974-E984. doi: 10.1503/cmaj.180144

Gutenstein, M., Pickering, J. W., & Than, M. (2018). Development of a digital clinical pathway for emergency medicine: Lessons from usability testing and implementation failure. Health Informatics Journal. Advance online publication. doi: 10.1177/1460458218779099

Ribitsch, W., Schilcher, G., Quehenberger, F., Pilz, S., Portugaller, R. H., Truschnig-Wilders, M., … Pickering, J. W., & Horina, J. H. (2017). Neutrophil gelatinase-associated lipocalin (NGAL) fails as an early predictor of contrast induced nephropathy in chronic kidney disease (ANTI-CI-AKI study). Scientific Reports, 7, 41300. doi: 10.1038/srep41300

Chapman, A. R., Lee, K. K., McAllister, D. A., Cullen, L., Greenslade, J. H., Parsonage, W., … Pickering, J. W., Than, M. P., … Adamson, P., … Mills, N. L. (2017). Association of high-sensitivity cardiac troponin I concentration with cardiac outcomes in patients with suspected acute coronary syndrome. JAMA, 318(19), 1913-1924. doi: 10.1001/jama.2017.17488

Mohamed, F., Buckley, N. A., Pickering, J. W., Wunnapuk, K., Dissanayake, S., Chathuranga, U., … Endre, Z. H. (2017). Nephrotoxicity-induced proteinuria increases biomarker diagnostic thresholds in acute kidney injury. BMC Nephrology, 18(1), 122. doi: 10.1186/s12882-017-0532-7

Puckett, J. R., Pickering, J. W., Palmer, S. C., McCall, J. L., Kluger, M. T., De Zoysa, J., Endre, Z. H., & Soop, M. (2017). Low versus standard urine output targets in patients undergoing major abdominal surgery: A randomized noninferiority trial. Annals of Surgery, 265(5), 874-881. doi: 10.1097/sla.0000000000002044

Wildi, K., Cullen, L., Twerenbold, R., Greenslade, J. H., Parsonage, W., Boeddinghaus, J., … Pickering, J. W., Than, M., & Mueller, C. (2017). Direct comparison of 2 rule-out strategies for acute myocardial infarction: 2-h accelerated diagnostic protocol vs 2-h algorithm. Clinical Chemistry, 63(7), 1227-1236. doi: 10.1373/clinchem.2016.268359

Pianta, T. J., Pickering, J. W., Succar, L., Chin, M., Davidson, T., Buckley, N. A., … Endre, Z. H. (2017). Dexamethasone modifies cystatin C-based diagnosis of acute kidney injury during cisplatin-based chemotherapy. Kidney & Blood Pressure Research, 62-75. doi: 10.1159/000469715

Greenslade, J. H., Nayer, R., Parsonage, W., Doig, S., Young, J., Pickering, J. W., Than, M., … Cullen, L. (2017). Validating the Manchester Acute Coronary Syndromes (MACS) and Troponin-only Manchester Acute Coronary Syndromes (T-MACS) rules for the prediction of acute myocardial infarction in patients presenting to the emergency department with chest pain. Emergency Medicine Journal, 34(8), 517-523. doi: 10.1136/emermed-2016-206366

Neumann, J. T., Sörensen, N. A., Ojeda, F., Schwemer, T., Lehmacher, J., Gönner, S., … Pickering, J. W., … Blankenberg, S. (2017). Immediate rule-out of acute myocardial infarction using electrocardiogram and baseline high-sensitivity troponin I. Clinical Chemistry, 63(1), 394-402. doi: 10.1373/clinchem.2016.262659

The New Zealand Emergency Medicine Network, including Gutenstein, M., and the Shorter Stays in Emergency Department National Research Project Group, including Pickering, J. (2017). National audit of the quality of pain relief provided in emergency departments in Aotearoa, New Zealand: The PRiZED 1 Study. Emergency Medicine Australasia, 29(2), 165-172. doi: 10.1111/1742-6723.12714

Pickering, J. W., Than, M. P., Cullen, L., Aldous, S., ter Avest, E., Body, R., … Florkowski, C. M., … George, P., … Pemberton, C., Richards, A. M., … Troughton, R., … Young, J. (2017). Rapid rule-out of acute myocardial infarction with a single high-sensitivity cardiac troponin T measurement below the limit of detection: A collaborative meta-analysis. Annals of Internal Medicine, 166(10), 715-724. doi: 10.7326/m16-2562

Succar, L., Pianta, T. J., Davidson, T., Pickering, J. W., & Endre, Z. H. (2017). Subclinical chronic kidney disease modifies the diagnosis of experimental acute kidney injury. Kidney International, 92(3), 680-692. doi: 10.1016/j.kint.2017.02.030

Trambas, C., Pickering, J. W., Than, M., Bain, C., Nie, L., Paul, E., … Schneider, H. G. (2016). Impact of high-sensitivity troponin I testing with sex-specific cutoffs on the diagnosis of acute myocardial infarction. Clinical Chemistry, 62(6), 831-838. doi: 10.1373/clinchem.2015.252569

Pickering, J. W., & Endre, Z. H. (2016). Bench to bedside: The next steps for biomarkers in acute kidney injury. American Journal of Physiology: Renal Physiology, 311(4), F717-F721. doi: 10.1152/ajprenal.00268.2016

Cullen, L., Greenslade, J. H., Menzies, L., Leong, A., Than, M., Pemberton, C., Aldous, S., Pickering, J., … Parsonage, W. A. (2016). Time to presentation and 12-month health outcomes in patients presenting to the emergency department with symptoms of possible acute coronary syndrome. Emergency Medicine Journal, 33, 390-395. doi: 10.1136/emermed-2015-204978

Mohamed, F., Endre, Z. H., Pickering, J. W., Jayamanne, S., Palangasinghe, C., Shahmy, S., … Buckley, N. A. (2016). Mechanism-specific injury biomarkers predict nephrotoxicity early following glyphosate surfactant herbicide (GPSH) poisoning. Toxicology Letters, 258, 1-10. doi: 10.1016/j.toxlet.2016.06.001

Flaws, D., Than, M., Scheuermeyer, F. X., Christenson, J., Boychuk, B., Greenslade, J. H., … Deely, J. M., Pickering, J. W., & Cullen, L. (2016). External validation of the emergency department assessment of chest pain score accelerated diagnostic pathway (EDACS-ADP). Emergency Medicine Journal, 33, 618-625. doi: 10.1136/emermed-2015-205028

Md Ralib, A., Mat Nor, M. B., & Pickering, J. W. (2016). Plasma Neutrophil Gelatinase-Associated Lipocalin diagnosed acute kidney injury in patients with systemic inflammatory disease and sepsis. Nephrology, 22(5), 412-419. doi: 10.1111/nep.12796

Boeddinghaus, J., Reichlin, T., Cullen, L., Greenslade, J. H., Parsonage, W. A., Hammett, C., Pickering, J. W., … Aldous, S., … Than, M., & Mueller, C. (2016). Two-hour algorithm for triage towards rule-out and rule-in of acute myocardial infarction by use of high-sensitivity cardiac troponin I. Clinical Chemistry, 62(3), 494-504. doi: 10.1373/clinchem.2015.249508

Than, M. P., Pickering, J. W., Aldous, S. J., Cullen, L., Frampton, C. M. A., Peacock, W. F., … Richards, A. M., Ardagh, M. W., Deely, J. M., Florkowski, C. M., George, P., Hamilton, G. J., Jardine, D. L., Troughton, R. W., … Lord, S. J. (2016). Effectiveness of EDACS versus ADAPT accelerated diagnostic pathways for chest pain: A pragmatic randomized controlled trial embedded within practice. Annals of Emergency Medicine, 68(1), 93-102. doi: 10.1016/j.annemergmed.2016.01.001

Lennartz, C. S., Pickering, J. W., Seiler-Mußler, S., Bauer, L., Untersteller, K., Emrich, I. E., … Heine, G. H. (2016). External validation of the kidney failure risk equation and re-calibration with addition of ultrasound parameters. Clinical Journal of the American Society of Nephrology, 11(4), 609-615. doi: 10.2215/cjn.08110715

Mat-Nor, M. B., Ralib, A. M., Abdulah, N. Z., & Pickering, J. W. (2016). The diagnostic ability of procalcitonin and Interleukin-6 to differentiate infectious from non-infectious systemic inflammatory response syndrome and to predict mortality. Journal of Critical Care, 33, 245-251. doi: 10.1016/j.jcrc.2016.01.002

Greenslade, J. H., Parsonage, W., Than, M., Scott, A., Aldous, S., Pickering, J. W., … Cullen, L. (2016). A clinical decision rule to identify emergency department patients at low risk for acute coronary syndrome who do not need objective coronary artery disease testing: The no objective testing rule. Annals of Emergency Medicine, 67(4), 478-489. doi: 10.1016/j.annemergmed.2015.08.006

Young, J. M., Pickering, J. W., George, P. M., Aldous, S. J., Wallace, J., Frampton, C. M., Troughton, R. W., Richards, A. M., … Than, M. P. (2016). Heart Fatty Acid Binding Protein and cardiac troponin: Development of an optimal rule-out strategy for acute myocardial infarction. BMC Emergency Medicine, 16(1), 34. doi: 10.1186/s12873-016-0089-y

Sanders, S., Flaws, D., Than, M., Pickering, J. W., Doust, J., & Glasziou, P. (2016). Simplification of a scoring system maintained overall accuracy but decreased the proportion classified as low risk. Journal of Clinical Epidemiology, 69, 32-39. doi: 10.1016/j.jclinepi.2015.05.006

Pickering, J. W., Greenslade, J. H., Cullen, L., Flaws, D., Parsonage, W., Aldous, S., George, P., … Than, M. P. (2016). Assessment of the European Society of Cardiology 0-Hour/1-Hour algorithm to rule-out and rule-in acute myocardial infarction. Circulation, 134(20), 1532-1541. doi: 10.1161/circulationaha.116.022677

Parsonage, W. A., Mueller, C., Greenslade, J. H., Wildi, K., Pickering, J., Than, M., … Cullen, L. (2016). Validation of NICE diagnostic guidance for rule out of myocardial infarction using high-sensitivity troponin tests. Heart, 102, 1279-1286. doi: 10.1136/heartjnl-2016-309270

Endre, Z. H., Pianta, T. J., & Pickering, J. W. (2016). Timely diagnosis of acute kidney injury using kinetic eGFR and the creatinine excretion to production ratio, E/eG: Creatinine can be useful! Nephron Clinical Practice, 132, 312-316. doi: 10.1159/000444456

Cullen, L., Greenslade, J. H., Carlton, E. W., Than, M., Pickering, J. W., Ho, A., … Parsonage, W. A. (2016). Sex-specific versus overall cut points for a high sensitivity troponin I assay in predicting 1-year outcomes in emergency patients presenting with chest pain. Heart, 102, 102-126. doi: 10.1136/heartjnl-2015-308506

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