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Professor John Pickering

Professor

John Pickering

BSc(Hons) PhD BA(Hons)

Email john.pickering@otago.ac.nz

Ahorangi Rangahau (Research Professor) John Pickering joined the Department of Medicine in 2007, initially to study how to better diagnose and tread kidney failure in the intensive care.  Now, he is a kaipūtaiao (scientist) and kaitātara koiora (biostatistician) with the Rangahau Manawa o Ōtautahi (Christchurch Heart Institute) and Big Data and Ageing research groups of University of Ōtago Christchurch, and the Emergency medicine research group of Christchurch Hospital. His interests include optimising the use of biomarkers for diagnosis, clinical pathway development and translational research in acute care, and using the interRAI data to improve the well-being of older persons.

He comes from a physics background and was once part of the team that pioneered the use of lasers to remove birthmarks.

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Publications

Norman, T., Young, J., Jones, J. S., Egan, G., Pickering, J., Du Toit, S., … Miller, R., Frampton, C., … George, P., & Than, M. (2022). Implementation and evaluation of a rural general practice assessment pathway for possible cardiac chest pain using point-of-care troponin testing: A pilot study. BMJ Open, 12, e044801. doi: 10.1136/bmjopen-2020-044801

Doudesis, D., Lee, K. K., Yang, J., Wereski, R., Shah, A. S. V., Tsanas, A., … Pickering, J. W., … on behalf of the High-STEACS Investigators. (2022). Validation of the myocardial-ischaemic-injury-index machine learning algorithm to guide the diagnosis of myocardial infarction in a heterogenous population: A prespecified exploratory analysis. Lancet Digital Health, 4, e300-e308. doi: 10.1016/s2589-7500(22)00025-5

Miller, R., Nixon, G., Pickering, J. W., Stokes, T., Turner, R. M., Young, J., Gutenstein, M., Smith, M., … Watson, A., George, P., … Than, M. (2022). A prospective multi-centre study assessing the safety and effectiveness following the implementation of an accelerated chest pain pathway using point-of-care troponin for use in New Zealand rural hospital and primary care settings. European Heart Journal: Acute Cardiovascular Care. Advance online publication. doi: 10.1093/ehjacc/zuac037

Templeton, E. M., Lassé, M., Kleffmann, T., Ellmers, L. J., Palmer, S. C., Davidson, T., Scott, N. J. A., Pickering, J. W., Charles, C. J., Endre, Z. H., Cameron, V. A., Richards, A. M., Rademaker, M. T., & Pilbrow, A. P. (2022). Identifying candidate protein markers of acute kidney injury in acute decompensated heart failure. International Journal of Molecular Sciences, 23, 1009. doi: 10.3390/ijms23021009

Than, M. P., Pickering, J. W., Adamson, P., Clendon, T., Florkowski, C. M., Lainchbury, J., Loubser, J., … Aldous, S. J. (2021). Reducing patient risk and enhancing care through the development and implementation of a new chest pain pathway, expedited by and for the COVID-19 era. eJIFCC, 32(1), 27-40.

Pickering, J. W., & Endre, Z. H. (2012). The metamorphosis of acute renal failure to acute kidney injury. In M. Sahay (Ed.), Basic nephrology and acute kidney injury. (pp. 125-150). Rijeka, Croatia: InTech. doi: 10.5772/1298

Chapter in Book - Research

Pickering, J. W. (2008). Plagiarism. In V. N. Parrillo (Ed.), Encyclopedia of social problems (Vol. 2). (pp. 664-667). Thousand Oaks, CA: SAGE.

Chapter in Book - Research

McGrath, T., Butcher, A., Koo, Y., Pickering, J., & Smith, H. (2007). Engaging Asian communities in Aotearoa New Zealand: An exploration of what works in community research. In A. Williamson & R. DeSouza (Eds.), Researching with communities: Grounded perspectives on engaging communities in research. (pp. 385-398). Auckland, New Zealand: Muddy Creek Press.

Chapter in Book - Research

Leong, F. T. L., Zhang, H., Pickering, J., & Chang, J. (2008). Family and home country influences on adjustment (Case Incident 7: Responses). In N. Arthur & P. Pedersen (Eds.), Case incidents in counseling for international transitions. (pp. 99-112). Alexandria, VA: American Counseling Association.

Chapter in Book - Other

Doudesis, D., Lee, K. K., Yang, J., Wereski, R., Shah, A. S. V., Tsanas, A., … Pickering, J. W., … on behalf of the High-STEACS Investigators. (2022). Validation of the myocardial-ischaemic-injury-index machine learning algorithm to guide the diagnosis of myocardial infarction in a heterogenous population: A prespecified exploratory analysis. Lancet Digital Health, 4, e300-e308. doi: 10.1016/s2589-7500(22)00025-5

Journal - Research Article

Miller, R., Nixon, G., Pickering, J. W., Stokes, T., Turner, R. M., Young, J., Gutenstein, M., Smith, M., … Watson, A., George, P., … Than, M. (2022). A prospective multi-centre study assessing the safety and effectiveness following the implementation of an accelerated chest pain pathway using point-of-care troponin for use in New Zealand rural hospital and primary care settings. European Heart Journal: Acute Cardiovascular Care. Advance online publication. doi: 10.1093/ehjacc/zuac037

Journal - Research Article

Norman, T., Young, J., Jones, J. S., Egan, G., Pickering, J., Du Toit, S., … Miller, R., Frampton, C., … George, P., & Than, M. (2022). Implementation and evaluation of a rural general practice assessment pathway for possible cardiac chest pain using point-of-care troponin testing: A pilot study. BMJ Open, 12, e044801. doi: 10.1136/bmjopen-2020-044801

Journal - Research Article

Templeton, E. M., Lassé, M., Kleffmann, T., Ellmers, L. J., Palmer, S. C., Davidson, T., Scott, N. J. A., Pickering, J. W., Charles, C. J., Endre, Z. H., Cameron, V. A., Richards, A. M., Rademaker, M. T., & Pilbrow, A. P. (2022). Identifying candidate protein markers of acute kidney injury in acute decompensated heart failure. International Journal of Molecular Sciences, 23, 1009. doi: 10.3390/ijms23021009

Journal - Research Article

Abey-Nesbit, R., Peel, N. M., Matthews, H., Hubbard, R. E., Nishtala, P. S., Bergler, U., Deely, J. M., Pickering, J. W., Schluter, P. J., & Jamieson, H. A. (2021). Frailty of Māori, Pasifika, and non-Māori/non-Pasifika older people in New Zealand: A national population study of older people referred for home care services. Journals of Gerontology Series A, 76(6), 1101-1107. doi: 10.1093/gerona/glaa265

Journal - Research Article

Heidari, K., Arani, M. A., Sheibani, M., Pickering, J. W., & Chouhdari, A. (2021). Comparison of two diagnostic protocols in the management of possible cardiac chest pain: One follow-up study in Iran. Caspian Journal of Internal Medicine, 12(2), 148-154. doi: 10.22088/cjim.12.2.148

Journal - Research Article

Lamba, M., Pickering, J. W., Than, M., Iles, S., & Beckert, L. (2021). Long-term outcomes in patients with pulmonary embolism: Results from a longitudinal cohort study. Internal Medicine Journal, 51, 699-704. doi: 10.1111/imj.14409

Journal - Research Article

Templeton, E. M., Cameron, V. A., Pickering, J. W., Richards, A. M., & Pilbrow, A. P. (2021). Emerging microRNA biomarkers for acute kidney injury in acute decompensated heart failure. Heart Failure Reviews, 26, 1203-1217. doi: 10.1007/s10741-020-09928-w

Journal - Research Article

Than, M. P., Pickering, J. W., Adamson, P., Clendon, T., Florkowski, C. M., Lainchbury, J., Loubser, J., … Aldous, S. J. (2021). Reducing patient risk and enhancing care through the development and implementation of a new chest pain pathway, expedited by and for the COVID-19 era. eJIFCC, 32(1), 27-40.

Journal - Research Article

Villacorta, H., Pickering, J. W., Horiuchi, Y., Olim, M., Coyne, C., Maisel, A. S., & Than, M. P. (2021). Machine learning with D-dimer in the risk stratification for pulmonary embolism: A derivation and internal validation study. European Heart Journal: Acute Cardiovascular Care. Advance online publication. doi: 10.1093/ehjacc/zuab089

Journal - Research Article

Vincent, A., Pearson, S., Pickering, J. W., Weaver, J., Toney, L., Hamill, L., Hurrell, M., & Than, M. (2021). Sensitivity of modern multislice CT for subarachnoid haemorrhage at incremental timepoints after headache onset: A 10-year analysis. Emergency Medicine Journal. Advance online publication. doi: 10.1136/emermed-2020-211068

Journal - Research Article

Albert, C., Zapf, A., Haase, M., Röver, C., Pickering, J. W., Albert, A., … Haase-Fielitz, A. (2020). Neutrophil gelatinase-associated lipocalin measured on clinical laboratory platforms for the prediction of acute kidney injury and the associated need for dialysis therapy: A systematic review and meta-analysis. American Journal of Kidney Diseases, 76(6), 826-841. doi: 10.1053/j.ajkd.2020.05.015

Journal - Research Article

Burnside, M., Crocket, H., Mayo, M., Pickering, J., Tappe, A., & de Bock, M. (2020). Do-it-yourself automated insulin delivery: A leading example of the democratization of medicine. Journal of Diabetes Science & Technology, 14(5), 878-882. doi: 10.1177/1932296819890623

Journal - Research Article

Chan, M. Y., Efthymios, M., Tan, S. H., Pickering, J. W., Troughton, R., Pemberton, C., … Pilbrow, A., & Richards, A. M. (2020). Prioritizing candidates of post-myocardial infarction heart failure using plasma proteomics and single-cell transcriptomics. Circulation, 142, 1408-1421. doi: 10.1161/circulationaha.119.045158

Journal - Research Article

Chiew, A. L., James, L. P., Isbister, G. K., Pickering, J. W., McArdle, K., Chan, B. S. H., & Buckley, N. A. (2020). Early acetaminophen-protein adducts predict hepatotoxicity following overdose (ATOM-5). Journal of Hepatology, 72, 450-462. doi: 10.1016/j.jhep.2019.10.030

Journal - Research Article

Diefenhardt, P., Pickering, J. W., & Heine, G. H. (2020). Erlaubt eine Bestimmung von FGF23 bei chronisch nierenkranken Menschen eine verbesserte Vorhersage renaler und kardiovaskulärer Ereignisse? [Does a determination of FGF23 in chronic kidney disease allow improved prediction of renal and cardiovascular events?]. Der Nephrologe, 15, 112-113. doi: 10.1007/s11560-019-00399-1

Journal - Research Article

Greenslade, J. H., Sieben, N., Parsonage, W. A., Knowlman, T., Ruane, L., Than, M., Pickering, J. W., … Cullen, L. (2020). Factors influencing physician risk estimates for acute cardiac events in emergency patients with suspected acute coronary syndrome. Emergency Medicine Journal, 37, 2-7. doi: 10.1136/emermed-2019-208916

Journal - Research Article

Hertzberg, D. P., Luksha, Y., Kus, I., Eslampia, P., Pickering, J. W., & Holzmann, M. J. (2020). Gait speed at discharge and risk for readmission or death: A prospective study of an emergency ward population. Open Access Emergency Medicine, 12, 127-135. doi: 10.2147/OAEM.S229479

Journal - Research Article

Jamieson, H. A., Abey-Nesbit, R., & Pickering, J. W. (2020). Effect of capacity to undertake instrumental activities of daily living on entry to aged residential care in older people with heart failure. Frontiers in Medicine, 7, 386. doi: 10.3389/fmed.2020.00386

Journal - Research Article

Jamieson, H., Abey-Nesbit, R., Nishtala, P. S., Allore, H., Han, L., Deely, J. M., & Pickering, J. W. (2020). Predictors of residential care admission in community-dwelling older people with dementia. Journal of the American Medical Directors Association, 21(11), 1665-1670. doi: 10.1016/j.jamda.2020.04.021

Journal - Research Article

Pickering, J. W., Abey-Nesbit, R., Allore, H., & Jamieson, H. (2020). Development and validation of multivariable mortality risk-prediction models in older people undergoing an interRAI home-care assessment (RiskOP). eClinicalMedicine, 29-30, 100614. doi: 10.1016/j.eclinm.2020.100614

Journal - Research Article

Pickering, J. W., Young, J. M., George, P. M., Pemberton, C. J., Watson, A., Aldous, S. J., … Troughton, R. W., Richards, A. M., … Than, M. P. (2020). Early kinetic profiles of troponin I and T measured by high-sensitivity assays in patients with myocardial infarction. Clinica Chimica Acta, 505, 15-25. doi: 10.1016/j.cca.2020.02.009

Journal - Research Article

Sanchis, J., Valero, E., Blas, S. G., Barba, E., Pernias, V., Miñana, G., … Pickering, J. W. (2020). Undetectable high-sensitivity troponin in combination with clinical assessment for risk stratification of patients with chest pain and normal troponin at hospital arrival. European Heart Journal: Acute Cardiovascular Care, 9(6), 567-575. doi: 10.1177/2048872620907539

Journal - Research Article

Adamson, P. D., McAllister, D., Pilbrow, A., Pickering, J. W., Poppe, K., Shah, A., Whalley, G., … Pemberton, C., Troughton, R. W., … Richards, A. M. (2019). Convalescent troponin and cardiovascular death following acute coronary syndrome. Heart, 105, 1717-1724. doi: 10.1136/heartjnl-2019-315084

Journal - Research Article

Gutenstein, M., Pickering, J. W., & Than, M. (2019). Development of a digital clinical pathway for emergency medicine: Lessons from usability testing and implementation failure. Health Informatics Journal, 25(4), 1563-1571. doi: 10.1177/1460458218779099

Journal - Research Article

Hertzberg, D. P., Sartipy, U., Lund, L. H., Rydén, L., Pickering, J. W., & Holzmann, M. J. (2019). Heart failure and the risk of acute kidney injury in relation to ejection fraction in patients undergoing coronary artery bypass grafting. International Journal of Cardiology, 274, 66-70. doi: 10.1016/j.ijcard.2018.09.092

Journal - Research Article

Hertzberg, D., Holzmann, M. J., Than, M., & Pickering, J. W. (2019). Acute kidney injury in patients presenting with chest pain to the emergency department: A descriptive study of the most common discharge diagnoses and mortality. European Journal of Emergency Medicine, 26(4), 242-248. doi: 10.1097/mej.0000000000000552

Journal - Research Article

Nestelberger, T., Cullen, L., Lindahl, B., Reichlin, T., Greenslade, J. H., Giannitsis, E., … Pickering, J. W., Than, M., on behalf of the APACE, ADAPT and TRAPID-AMI Investigators. (2019). Diagnosis of acute myocardial infarction in the presence of left bundle branch block. Heart, 105, 1559-1567. doi: 10.1136/heartjnl-2018-314673

Journal - Research Article

Neumann, J. T., Twerenbold, R., Ojeda, F., Sörensen, N. A., Chapman, A. R., Shah, A. S. V., … Pickering, J. W., Troughton, R. W., … Than, M., … Blankenberg, S. (2019). Application of high-sensitivity troponin in suspected myocardial infarction. New England Journal of Medicine, 380(26), 2529-2540. doi: 10.1056/NEJMoa1803377

Journal - Research Article

Than, M. P., Pickering, J. W., Sandoval, Y., Shah, A. S. V., Tsanas, A., Apple, F. S., … on behalf of the MI3 Collaborative. (2019). Machine learning to predict the likelihood of acute myocardial infarction. Circulation, 140, 899-909. doi: 10.1161/circulationaha.119.041980

Journal - Research Article

Carlton, E. W., Pickering, J. W., Greenslade, J., Cullen, L., Than, M., Kendall, J., … Greaves, K. (2018). Assessment of the 2016 National Institute for Health and Care Excellence high-sensitivity troponin rule-out strategy. Heart, 104(8), 665-672. doi: 10.1136/heartjnl-2017-311983

Journal - Research Article

Farnaz, B., Payman, I., Mohammad, R., Pickering, J. W., & Seyed-Mostafa, H.-Z. (2018). Incidence of non-alcoholic fatty liver disease among referral outpatients to the internal medicine clinic. Asian Journal of Pharmaceutics, 12(Suppl. 1), S323-S327. doi: 10.22377/ajp.v12i01

Journal - Research Article

Greenslade, J. H., Chung, K., Parsonage, W. A., Hawkins, T., Than, M., Pickering, J. W., & Cullen, L. (2018). Modification of the Thrombolysis in Myocardial Infarction risk score for patients presenting with chest pain to the emergency department. Emergency Medicine Australasia, 30(1), 47-54. doi: 10.1111/1742-6723.12913

Journal - Research Article

Kavsak, P. A., Neumann, J. T., Cullen, L., Than, M., Shortt, C., Greenslade, J. H., Pickering, J. W., … Troughton, R., … Worster, A. (2018). Clinical chemistry score versus high-sensitivity cardiac troponin I and T tests alone to identify patients at low or high risk for myocardial infarction or death at presentation to the emergency department. CMAJ, 190(33), E974-E984. doi: 10.1503/cmaj.180144

Journal - Research Article

McIlroy, D. R., Farkas, D., Pan, K., Pickering, J. W., & Lee, H. T. (2018). Combining novel renal injury markers with delta serum creatinine early after cardiac surgery and risk-stratification for serious adverse outcomes: An exploratory analysis. Journal of Cardiothoracic & Vascular Anesthesia, 32(5), 2190-2200. doi: 10.1053/j.jvca.2017.12.052

Journal - Research Article

Pickering, J. W., Blunt, I. R. H., & Than, M. P. (2018). Acute kidney injury and mortality prognosis in acute coronary syndrome patients: A meta-analysis. Nephrology, 23(3), 237-246. doi: 10.1111/nep.12984

Journal - Research Article

Pickering, J. W., Flaws, D., Smith, S. W., Greenslade, J., Cullen, L., Parsonage, W., … Richards, A. M., Troughton, R., Pemberton, C., George, P. M., & Than, M. P. (2018). A risk assessment score and initial high-sensitivity troponin combine to identify low risk of acute myocardial infarction in the emergency department. Academic Emergency Medicine, 25(4), 434-443. doi: 10.1111/acem.13343

Journal - Research Article

Pickering, J. W., Young, J. M., George, P. M., Watson, A. S., Aldous, S. J., Troughton, R. W., Pemberton, C. J., Richards, A. M., … Than, M. P. (2018). Validity of a novel point-of-care troponin assay for single-test rule-out of acute myocardial infarction. JAMA Cardiology, 3(11), 1108-1112. doi: 10.1001/jamacardio.2018.3368

Journal - Research Article

Seiler-Mussler, S., Limbach, A. S., Emrich, I. E., Pickering, J. W., Roth, H. J., Fliser, D., & Heine, G. H. (2018). Association of nonoxidized parathyroid hormone with cardiovascular and kidney disease outcomes in chronic kidney disease. Clinical Journal of the American Society of Nephrology, 13(4), 569-576. doi: 10.2215/cjn.06620617

Journal - Research Article

Than, M. P., Aldous, S. J., Troughton, R. W., Pemberton, C. J., Richards, A. M., Frampton, C. M. A., Florkowski, C. M., George, P. M., … Young, J. M., … Pickering, J. W. (2018). Detectable high-sensitivity cardiac troponin within the population reference interval conveys high 5-year cardiovascular risk: An observational study. Clinical Chemistry, 64(7), 1044-1053. doi: 10.1373/clinchem.2017.285700

Journal - Research Article

Than, M. P., Pickering, J. W., Dryden, J. M., Lord, S. J., Aitken, S. A., Aldous, S. J., … Ardagh, M. W., … Callender, R., … Deely, J. M., … Ferrier, K. A., … Frampton, C. M. A., George, P. M., … Matthews, T. J. E., … Peckler, B. F., … Richards, A. M., … Simmonds, M. B., … Troughton, R. W., … on behalf of the ICare-ACS Implementation Group. (2018). ICare-ACS (improving care processes for patients with suspected acute coronary syndrome): A study of cross-system implementation of a national clinical pathway. Circulation, 137(4), 354-363. doi: 10.1161/circulationaha.117.031984

Journal - Research Article

van der Linden, N., Wildi, K., Twerenbold, R., Pickering, J. W., Than, M., Cullen, L., … Richards, A. M., Troughton, R., Pemberton, C., … Mueller, C. (2018). Combining high sensitivity cardiac troponin I and cardiac troponin T in the early diagnosis of acute myocardial infarction. Circulation, 138(10), 989-999. doi: 10.1161/circulationaha.117.032003

Journal - Research Article

Chapman, A. R., Lee, K. K., McAllister, D. A., Cullen, L., Greenslade, J. H., Parsonage, W., … Pickering, J. W., Than, M. P., … Adamson, P., … Mills, N. L. (2017). Association of high-sensitivity cardiac troponin I concentration with cardiac outcomes in patients with suspected acute coronary syndrome. JAMA, 318(19), 1913-1924. doi: 10.1001/jama.2017.17488

Journal - Research Article

Greenslade, J. H., Nayer, R., Parsonage, W., Doig, S., Young, J., Pickering, J. W., Than, M., … Cullen, L. (2017). Validating the Manchester Acute Coronary Syndromes (MACS) and Troponin-only Manchester Acute Coronary Syndromes (T-MACS) rules for the prediction of acute myocardial infarction in patients presenting to the emergency department with chest pain. Emergency Medicine Journal, 34(8), 517-523. doi: 10.1136/emermed-2016-206366

Journal - Research Article

Mohamed, F., Buckley, N. A., Pickering, J. W., Wunnapuk, K., Dissanayake, S., Chathuranga, U., … Endre, Z. H. (2017). Nephrotoxicity-induced proteinuria increases biomarker diagnostic thresholds in acute kidney injury. BMC Nephrology, 18(1), 122. doi: 10.1186/s12882-017-0532-7

Journal - Research Article

Neumann, J. T., Sörensen, N. A., Ojeda, F., Schwemer, T., Lehmacher, J., Gönner, S., … Pickering, J. W., … Blankenberg, S. (2017). Immediate rule-out of acute myocardial infarction using electrocardiogram and baseline high-sensitivity troponin I. Clinical Chemistry, 63(1), 394-402. doi: 10.1373/clinchem.2016.262659

Journal - Research Article

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