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Anna PilbrowSenior Research Fellow

BSc(Hons) PhD(Otago)

Email anna.pilbrow@otago.ac.nz

Christchurch Heart Institute
Department of Medicine
University of Otago, Christchurch
P.O. Box 4345
Christchurch
New Zealand

Research interests

Cardiovascular Genetics and Genomics

Dr Pilbrow’s research explores how genetic variation contributes to susceptibility to heart disease.

Her research investigates genes and proteins within the heart and blood vessels that are altered in people genetically predisposed to heart disease and aims to identify new biomarkers that will help identify people at risk of having a heart attack. 

She is also working to identify genetic variants that increase the risk of heart disease in New Zealand families who have a strong family history of premature heart disease.

Background

Dr Pilbrow completed her PhD in Cardiovascular Genetics at the University of Otago, Christchurch in 2006.

She undertook postdoctoral training in the Christchurch Heart Institute (2006-2008) and the Peptide Biology Laboratory at The Salk Institute of Biological Sciences, San Diego (2008-2010), supported by a Foundation of Research, Science and Technology (now Ministry of Business, Innovation and Employment) Postdoctoral Fellowship.

Dr Pilbrow returned to New Zealand in 2010 to work with the Christchurch Heart Institute's Molecular Biology and Genetics Laboratory and was awarded the prestigious Sir Charles Hercus Fellowship award during 2011. The Hercus Fellowship was awarded Dr Pilbrow as an emerging scientist who has demonstrated outstanding potential and the ability to initiate new avenues of investigation.

Awards

  • ThermoFisher Scientific Award for Excellence in Molecular Biology, Queenstown Research Week, 2017
  • Heart Foundation Senior Fellowship, 2014
  • University of Otago Early Career Award for Distinction in Research, 2014
  • Sir Charles Hercus Health Research Fellowship, 2011

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Publications

Patel, R. S., Schmidt, A. F., Tragante, V., McCubrey, R. O., Holmes, M. V., Howe, L. J., … Pilbrow, A. P., … Richards, A. M., … Cameron, V. A., … Asselbergs, F. W. (2019). Association of chromosome 9p21 with subsequent coronary heart disease events: A GENIUS-CHD study of individual participant data. Circulation: Genomic & Precision Medicine, 12(4), 161-172. doi: 10.1161/circgen.119.002471

Patel, R., Tragante, V., Schmidt, A. F., McCubrey, R. O., Holmes, M. V., Howe, L. J., … Pilbrow, A. P., … Richards, A. M., … Cameron, V. A., … Asselbergs, F. W. (2019). Subsequent event risk in individuals with established coronary heart disease: Design and rationale of the GENIUS-CHD Consortium. Circulation: Genomic & Precision Medicine, 12(4), 145-160. doi: 10.1161/CIRCGEN.119.002470

Adamson, P. D., McAllister, D., Pilbrow, A., Pickering, J. W., Poppe, K., Shah, A., Whalley, G., … Pemberton, C., Troughton, R. W., … Richards, A. M. (2019). Convalescent troponin and cardiovascular death following acute coronary syndrome. Heart. Advance online publication. doi: 10.1136/heartjnl-2019-315084

Marks, E. C. A., Wilkinson, T. M., Frampton, C. M., Skelton, L., Pilbrow, A. P., Yandle, T. G., Pemberton, C. J., … Whalley, G. A., … Troughton, R. W., … Cameron, V. A., Richards, A. M., Gieseg, S. P., & Palmer, B. R. (2018). Plasma levels of soluble VEGF receptor isoforms, circulating pterins and VEGF system SNPs as prognostic biomarkers in patients with acute coronary syndromes. BMC Cardiovascular Disorders, 18, 169. doi: 10.1186/s12872-018-0894-1

Mehta-Mujoo, P., Landmann, M., Pilbrow, A. P., Currie, M. J., Morrin, H. R., Hung, N. A., & Slatter, T. L. (2018, August). Visualisation of long non-coding RNA ANRIL in breast cancer. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Chapter in Book - Other

Richards, M., Troughton, R., Espiner, E., Cameron, V., Ellmers, L., Pilbrow, A., Charles, C., Rademaker, M., Pemberton, C., & Yandle, T. (2013). Christchurch Heart Institute. In P. Joyce, G. Nicholls, K. Thomas & T. Wilkinson (Eds.), The Christchurch experience: 40 years of research and teaching. (pp. 68-74). Christchurch, New Zealand: University of Otago.

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Journal - Research Article

Patel, R. S., Schmidt, A. F., Tragante, V., McCubrey, R. O., Holmes, M. V., Howe, L. J., … Pilbrow, A. P., … Richards, A. M., … Cameron, V. A., … Asselbergs, F. W. (2019). Association of chromosome 9p21 with subsequent coronary heart disease events: A GENIUS-CHD study of individual participant data. Circulation: Genomic & Precision Medicine, 12(4), 161-172. doi: 10.1161/circgen.119.002471

Adamson, P. D., McAllister, D., Pilbrow, A., Pickering, J. W., Poppe, K., Shah, A., Whalley, G., … Pemberton, C., Troughton, R. W., … Richards, A. M. (2019). Convalescent troponin and cardiovascular death following acute coronary syndrome. Heart. Advance online publication. doi: 10.1136/heartjnl-2019-315084

Patel, R., Tragante, V., Schmidt, A. F., McCubrey, R. O., Holmes, M. V., Howe, L. J., … Pilbrow, A. P., … Richards, A. M., … Cameron, V. A., … Asselbergs, F. W. (2019). Subsequent event risk in individuals with established coronary heart disease: Design and rationale of the GENIUS-CHD Consortium. Circulation: Genomic & Precision Medicine, 12(4), 145-160. doi: 10.1161/CIRCGEN.119.002470

Marks, E. C. A., Wilkinson, T. M., Frampton, C. M., Skelton, L., Pilbrow, A. P., Yandle, T. G., Pemberton, C. J., … Whalley, G. A., … Troughton, R. W., … Cameron, V. A., Richards, A. M., Gieseg, S. P., & Palmer, B. R. (2018). Plasma levels of soluble VEGF receptor isoforms, circulating pterins and VEGF system SNPs as prognostic biomarkers in patients with acute coronary syndromes. BMC Cardiovascular Disorders, 18, 169. doi: 10.1186/s12872-018-0894-1

Scott, N. J. A., Ellmers, L. J., Pilbrow, A. P., Thomsen, L., Richards, A. M., Frampton, C. M., & Cameron, V. A. (2017). Metabolic and blood pressure effects of walnut supplementation in a mouse model of the metabolic syndrome. Nutrients, 9, 722. doi: 10.3390/nu9070722

Zewinger, S., Kleber, M. E., Tragante, V., McCubrey, R. O., Schmidt, A. F., Direk, K., … Pilbrow, A. P., Cameron, V. A., Richards, A. M., … on behalf of the GENIUS-CHD consortium, … Speer, T. (2017). Relations between lipoprotein(a) concentrations, LPA genetic variants, and the risk of mortality in patients with established coronary heart disease: A molecular and genetic association study. Lancet Diabetes & Endocrinology, 5(7), 534-543. doi: 10.1016/S2213-8587(17)30096-7

Hu, Y.-J., Schmidt, A. F., Dudbridge, F., Holmes, M. V., Brophy, J. M., Tragante, V., … on behalf of the GENIUS-CHD Consortium, including Cameron, V. A., Pilbrow, A. P., & Richards, A. M. (2017). Impact of selection bias on estimation of subsequent event risk. Circulation: Cardiovascular Genetics, 10(5), e001616. doi: 10.1161/CIRCGENETICS.116.001616

Pilbrow, A. P., Lewis, K. A., Perrin, M. H., Sweet, W. E., Moravec, C. S., Tang, W. H. W., … Troughton, R. W., & Cameron, V. A. (2016). Cardiac CRFR1 expression is elevated in human heart failure and modulated by genetic variation and alternative splicing. Endocrinology, 157(12), 4865-4874. doi: 10.1210/en.2016-1448

Royds, J. A., Pilbrow, A. P., Morrin, H. R., Frampton, C., Russell, I. A., Moravec, C. S., … Currie, M. J., Hung, N. A., & Slatter, T. L. (2016). The rs11515 polymorphism is more frequent and associated with aggressive breast tumors with increased ANRIL and decreased p16INK4a expression. Frontiers in Oncology, 5, 306. doi: 10.3389/fonc.2015.00306

Siriwardena, M., Pilbrow, A., Frampton, C., MacDonald, S. M., Wilkins, G. T., & Richards, A. M. (2015). Complications of intra-aortic balloon pump use: Does the final position of the IABP tip matter? Anaesthesia & Intensive Care, 43(1), 66-73.

Earle, N. J., Poppe, K. K., Pilbrow, A. P., Cameron, V. A., Troughton, R. W., Skinner, J. R., … Whalley, G. A., … Richards, A. M., & Doughty, R. N. (2015). Genetic markers of repolarization and arrhythmic events following acute coronary syndromes. American Heart Journal, 169(4), 579-586.e3. doi: 10.1016/j.ahj.2014.11.015

Cameron, V. A., & Pilbrow, A. P. (2014). Circulating microRNAs as biomarkers in coronary heart disease and heart failure. microRNA Diagnostics & Therapeutics, 1(1), 58-74.

Earle, N., Han, D. Y., Pilbrow, A., Crawford, J., Smith, W., Shelling, A. N., Cameron, V., … Skinner, J. R. (2014). Single nucleotide polymorphisms in arrhythmia genes modify the risk of cardiac events and sudden death in long QT syndrome. Heart Rhythm, 11(1), 76-82. doi: 10.1016/j.hrthm.2013.10.005

Palmer, B. R., Slow, S., Ellis, K. L., Pilbrow, A. P., Skelton, L., Frampton, C. M., Palmer, S. C., Troughton, R. W., Yandle, T. G., … Whalley, G. A., … Lever, M., George, P. M., Chambers, S. T., … Richards, A. M., & Cameron, V. A. (2014). Genetic polymorphism rs6922269 in the MTHFD1L gene is associated with survival and baseline active vitamin B12 levels in post-acute coronary syndromes patients. PLoS ONE, 9(3), e89029. doi: 10.1371/journal.pone.0089029

Pilbrow, A. P., Cordeddu, L., Cameron, V. A., Frampton, C. M., Troughton, R. W., Doughty, R. N., Whalley, G. A., … Yandle, T. G., Richards, A. M., & Foo, R. S.-Y. (2014). Circulating miR-323-3p and miR-652: Candidate markers for the presence and progression of acute coronary syndromes. International Journal of Cardiology, 176, 375-385. doi: 10.1016/j.ijcard.2014.07.068

Pilbrow, A. P., Folkersen, L., Pearson, J. F., Brown, C. M., McNoe, L., Wang, N. M., … Black, M. A., Troughton, R. W., Richards, A. M., … Cameron, V. A. (2012). The chromosome 9p21.3 coronary heart disease risk allele is associated with altered gene expression in normal heart and vascular tissues. PLoS ONE, 7(6), e39574. doi: 10.1371/journal.pone.0039574

Ellis, K. L., Palmer, B. R., Frampton, C. M., Troughton, R. W., Doughty, R. N., Whalley, G. A., … Pilbrow, A. P., Skelton, L., Yandle, T. G., Richards, A. M., & Cameron, V. A. (2012). Genetic variation in the renin-angiotensin-aldosterone system is associated with cardiovascular risk factors and early mortality in established coronary heart disease. Journal of Human Hypertension, 27, 237-244. doi: 10.1038/jhh.2012.24

Ellis, K. L., Pilbrow, A. P., Potter, H. C., Frampton, C. M., Doughty, R. N., Whalley, G. A., … Palmer, B. R., Skelton, L., Yandle, T. G., Troughton, R. W., Richards, A. M., & Cameron, V. A. (2012). Association between endothelin type A receptor haplotypes and mortality in coronary heart disease. Personalized Medicine, 9(3), 341-349. doi: 10.2217/PME.12.10

Ellis, K. L., Frampton, C. M., Pilbrow, A. P., Troughton, R. W., Doughty, R. N., Whalley, G. A., … Skelton, L., Thomson, J. A., Yandle, T. G., Richards, A. M., & Cameron, V. A. (2011). Genomic risk variants at 1p13.3, 1q41, and 3q22.3 are associated with subsequent cardiovascular outcomes in healthy controls and in established coronary artery disease. Circulation: Cardiovascular Genetics, 4(6), 636-646. doi: 10.1161/circgenetics.111.960336

Huising, M. O., Pilbrow, A. P., Matsumoto, M., van der Meulen, T., Park, H., Vaughan, J. M., … Vale, W. W. (2011). Glucocorticoids differentially regulate the expression of CRFR1 and CRFR2α in MIN6 insulinoma cells and rodent islets. Endocrinology, 152(1), 138-150. doi: 10.1210/en.2010-0791

Jarvis, M. D., Palmer, B. R., Pilbrow, A. P., Ellis, K. L., Frampton, C. M., Skelton, L., … Whalley, G. A., … Yandle, T. G., Richards, A. M., & Cameron, V. A. (2010). CYP1A1 MSPI (T6235C) gene polymorphism is associated with mortality in acute coronary syndrome patients. Clinical & Experimental Pharmacology & Physiology, 37(2), 193-198. doi: 10.1111/j.1440-1681.2009.05261.x

Ellis, K. L., Pilbrow, A. P., Frampton, C. M., Doughty, R. N., Whalley, G. A., Ellis, C. J., Palmer, B. R., Skelton, L., Yandle, T. G., Palmer, S. C., Troughton, R. W., Richards, A. M., & Cameron, V. A. (2010). A common variant at chromosome 9P21.3 is associated with age of onset of coronary disease but not subsequent mortality. Circulation: Cardiovascular Genetics, 3(3), 286-293. doi: 10.1161/circgenetics.109.917443

Lainchbury, J. G., Troughton, R. W., Strangman, K. M., Frampton, C. M., Pilbrow, A., Yandle, T. G., … Nicholls, M. G., & Richards, A. M. (2010). N-terminal pro-B-type natriuretic peptide-guided treatment for chronic heart failure: Results from the BATTLESCARRED (NT-proBNP-assisted treatment to lessen serial cardiac readmissions and death) trial. JACC, 55(1), 53-60. doi: 10.1016/j.jacc.2009.02.095

Palmer, B. R., Devereaux, C. L., Dhamrait, S. S., Mocatta, T. J., Pilbrow, A. P., Frampton, C. M., Skelton, L., Yandle, T. G., Winterbourn, C. C., Richards, A. M., … Cameron, V. A. (2009). The common G-866A polymorphism of the UCP2 gene and survival in diabetic patients following myocardial infarction. Cardiovascular Diabetology, 8. doi: 10.1186/1475-2840-8-31

Molyneux, S. L., Florkowski, C. M., George, P. M., Pilbrow, A. P., Frampton, C. M., Lever, M., & Richards, A. M. (2008). Coenzyme Q10: An independent predictor of mortality in chronic heart failure. JACC, 52(18), 1435-1441. doi: 10.1016/j.jacc.2008.07.044

Pilbrow, A. P., Ellmers, L. J., Black, M. A., Moravec, C. S., Sweet, W. E., Troughton, R. W., Richards, A. M., Frampton, C. M., & Cameron, V. A. (2008). Genomic selection of reference genes for real-time PCR in human myocardium. BMC Medical Genomics, 1, 64. doi: 10.1186/1755-8794-1-64

Palmer, B. R., Pilbrow, A. P., Frampton, C. M., Yandle, T. G., Skelton, L., Nicholls, M. G., & Richards, A. M. (2008). Plasma aldosterone levels during hospitalization are predictive of survival post-myocardial infarction. European Heart Journal, 29, 2489-2496. doi: 10.1093/eurheartj/ehn383

Palmer, B. R., Jarvis, M. D., Pilbrow, A. P., Ellis, K. L., Frampton, C. M., Skelton, L., Yandle, T. G., … Whalley, G. A., … Troughton, R. W., Richards, A. M., & Cameron, V. A. (2008). Angiotensin-converting enzyme 2 A1075G polymorphism is associated with survival in an acute coronary syndromes cohort. American Heart Journal, 156(4), 752-758. doi: 10.1016/j.ahj.2008.06.013

Littlejohn, M. D., Palmer, B. R., Richards, A. M., Frampton, C. M., Pilbrow, A. P., Troughton, R. W., Cameron, V. A., & Kennedy, M. A. (2008). Ile164 variant of β2-adrenoceptor does not influence outcome in heart failure but may interact with β blocker treatment. European Journal of Heart Failure, 10(1), 55-59. doi: 10.1016/j.ejheart.2007.10.011

Ellmers, L. J., Scott, N. J. A., Medicherla, S., Pilbrow, A. P., Bridgman, P. G., Yandle, T. G., Richards, A. M., … Cameron, V. A. (2008). Transforming growth factor-β blockade down-regulates the renin-angiotensin system and modifies cardiac remodeling after myocardial infarction. Endocrinology, 149(11), 5828-5834. doi: 10.1210/en.2008-0165

Pilbrow, A. P., Palmer, B. R., Frampton, C. M., Yandle, T. G., Troughton, R. W., Campbell, E., Skelton, L., Lainchbury, J. G., Richards, A. M., & Cameron, V. A. (2007). Angiotensinogen M235T and T174M gene polymorphisms in combination doubles the risk of mortality in heart failure. Hypertension, 49(2), 322-327.

Mocatta, T. J., Pilbrow, A. P., Cameron, V. A., Senthilmohan, R., Frampton, C. M., Richards, A. M., & Winterbourn, C. C. (2007). Plasma concentrations of myeloperoxidase predict mortality after myocardial infarction. JACC, 49(20), 1993-2000. doi: 10.1016/j.jacc.2007.02.040

Collins, R. P., Palmer, B. R., Pilbrow, A. P., Frampton, C. M., Troughton, R. W., Yandle, T. G., Skelton, L., Richards, A. M., & Cameron, V. A. (2006). Evaluation of AMPD1 C34T genotype as a predictor of mortality in heart failure and post-myocardial infarction patients. American Heart Journal, 152(2), 312-320.

Cameron, V. A., Mocatta, T. J., Pilbrow, A. P., Frampton, C. M., Troughton, R. W., Richards, A. M., & Winterbourn, C. C. (2006). Angiotensin type-1 receptor A1166C gene polymorphism correlates with oxidative stress levels in human heart failure. Hypertension, 47(6), 1155-1161.

Palmer, B. R., Pilbrow, A. P., Yandle, T. G., Frampton, C. M., Richards, A. M., Nicholls, M. G., & Cameron, V. A. (2003). Angiotensin-converting enzyme gene polymorphism interacts with left ventricular ejection fraction and brain natriuretic peptide levels to predict mortality after myocardial infarction. JACC, 41(5), 729-736. doi: 10.1016/S0735-1097(02)02927-3

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Journal - Research Other

Gupta, R. M., Pilbrow, A. P., & Weeke, P. E. (2015). Top advances in functional genomics and translational biology for 2014. Circulation: Cardiovascular Genetics, 8, 207-210. doi: 10.1161/CIRCGENETICS.115.001021

Pilbrow, A. P. (2014). Cardiac cell therapy in nonhuman primates: A significant step toward clinical translation. Circulation: Cardiovascular Genetics, 7(4), 565-566. doi: 10.1161/circgenetics.114.000800

Pilbrow, A. P. (2014). Discovery of an obesity susceptibility gene, KSR2, provides new insight into energy homeostasis pathways. Circulation: Cardiovascular Genetics, 7(2), 218-219. doi: 10.1161/CIRCGENETICS.114.000601

Pilbrow, A. P., Arora, P., & Martinez-Fernandez, A. (2014). Top advances in functional genomics and translational biology for 2013. Circulation: Cardiovascular Genetics, 7(1), 89-92. doi: 10.1161/CIRCGENETICS.114.000521

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Conference Contribution - Published proceedings: Abstract

Wheeler, N. E., Cameron, V. A., Pearson, J. F., Gardener, P. T., Moravec, C. S., Sweet, W. E., … Troughton, R. W., Richards, A. M., & Pilbrow, A. P. (2015). Expression quantitative trait locus (eQTL) map for genetic variants associated with cardiovascular traits in human heart. Circulation, 132, A17027. [Abstract]

Pilbrow, A. P., Frampton, C. M., Richards, A. M., Troughton, R. W., & Cameron, V. A. (2014). Elevated levels of circulating microRNA-223, microRNA-127 and microRNA-146a are associated with risk of near future cardiovascular events in asymptomatic individuals. Circulation, 130(Suppl. 2), A18066. [Abstract]

Earle, N., Poppe, K., Cameron, V., Pilbrow, A., Troughton, R., Skinner, J., … Richards, M., & Doughty, R. (2014). Risk of sudden cardiac death following acute coronary syndromes: Interplay of single nucleotide polymorphisms and the presence of heart failure. Heart, Lung & Circulation, 23(Suppl. 2), (pp. e9). doi: 10.1016/j.hlc.2014.07.023

Cameron, V. A., Pilbrow, A. P., Ellis, K. L., Palmer, B. R., Troughton, R. W., & Richards, A. M. (2014). Duelling hormones: The renin-aldosterone system versus the natriuretic peptides in heart disease. Proceedings of the Medical Sciences Congress (MedSci). (pp. 15). Retrieved from http://www.physoc.org.nz/meetings/archive/medsci-2014-abstracts

Pilbrow, A. P., Frampton, C. M., Richards, A. M., Troughton, R. W., & Cameron, V. A. (2014). Amino-terminal pro-brain natriuretic peptide improves risk stratification in asymptomatic individuals at very high risk of future cardiovascular events. Circulation, 130(Suppl. 2), A19648. [Abstract]

Cordeddu, L., Pilbrow, A. P., Cameron, V. A., Troughton, R. W., Richards, M. A., & Roger, S. (2012). Circulating miRNAs as biomarkers in acute coronary syndrome. Circulation Research, 111(4 Suppl. 1). [Abstract]

Pilbrow, A. P., Pearson, J. F., McNoe, L., Ellis, K. L., Black, M. A., Sweet, W. E., … Troughton, R. W., Richards, A. M., … Cameron, V. A. (2011). Chromosome 1q41 and 3q22.3 coronary artery disease risk loci are associated with altered cardiac gene expression profiles in normal and diseased heart. Circulation, 124, A12170. [Abstract]

Pilbrow, A. P., Cameron, V. A., Lewis, K. A., Perrin, M. H., Sweet, W. E., Troughton, R. W., … Vale, W. W. (2010). Levels of cardiac corticotropin-releasing factor type 1 receptor gene expression are up-regulated in heart failure and altered in association with a large inversion polymorphism that spans the gene. Endocrine Reviews, 31(3, Suppl. 1), (pp. S1815). [Abstract]

Cameron, V. A., Pilbrow, A. P., Palmer, B. R., Ellis, K. L., Pearson, J., Moravec, C. S., … Troughton, R. W., & Richards, A. M. (2009). Gene polymorphisms in patients with heart failure and acute coronary syndromes. CVD Prevention and Control. 4(Suppl. 1), (pp. S15). [Abstract]

Pilbrow, A. P., Pearson, J., Brown, C. M., McNoe, L., Black, M. A., Sweet, W. E., … Troughton, R. W., Richards, A. M., … Cameron, V. A. (2009). Chromosome 6q25.1 and 2q36.3 coronary heart disease risk loci are associated with altered cardiac gene expression profiles in normal heart. Circulation, 120(18, Suppl.), (pp. S564). [Abstract]

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