Emeritus Professor Eric Espiner, Our people, University of Otago, Christchurch, University of Otago, New Zealand

Eric Espiner MB ChB MD(Otago) FRACP FRSNZ

Christchurch Heart Institute
Department of Medicine
University of Otago, Christchurch
PO Box 4345
Christchurch 8140
New Zealand

Current Roles

Emeritus Professor

Research Interests

Natriuretic Peptides
C-type Natriuetic Peptide regulation and roles in cardiovascular disorders, fetal and maternal welfare, and linear growth.

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Publications

Prickett, T. C. R., Troughton, R. W., & Espiner, E. A. (2020). Effect of statin therapy on plasma C-type natriuretic peptides and endothelin-1 in males with and without symptomatic coronary artery disease. Scientific Reports, 10, 7927. doi: 10.1038/s41598-020-64795-7

Prickett, T. C. R., & Espiner, E. A. (2020). Circulating products of C-type natriuretic peptide and links with organ function in health and disease. Peptides, 132, 170363. doi: 10.1016/j.peptides.2020.170363

Espiner, E. A., & Prickett, T. C. R. (2020). New prospects for restoring skeletal growth in mucopolysaccharidoses. Endocrinology, 161(4), 1-3. doi: 10.1210/endocr/bqaa034

Prickett, T. C. R., Spittlehouse, J. K., Miller, A. L., Liau, Y., Kennedy, M. A., Cameron, V. A., Pearson, J. F., Boden, J. M., Troughton, R. W., & Espiner, E. A. (2019). Contrasting signals of cardiovascular health among natriuretic peptides in subjects without heart disease. Scientific Reports, 9, 12108. doi: 10.1038/s41598-019-48553-y

Prickett, T. C. R., Lunt, H., Warwick, J., Heenan, H. F., & Espiner, E. A. (2019). Urinary amino-terminal pro-C-type natriuretic peptide: A novel marker of chronic kidney disease in diabetes. Clinical Chemistry, 65(8), 10. doi: 10.1373/clinchem.2019.306910

Chapter in Book - Research
Chapter in Book - Other
Journal - Research Article

Chapter in Book - Research

Prickett, T. C. R., & Espiner, E. A. (2012). C-type natriuretic peptide (CNP) and postnatal linear growth. In V. R. Preedy (Ed.), Handbook of growth and growth monitoring in health and disease. (pp. 2789-2809). New York: Springer. doi: 10.1007/978-1-4419-1795-9

Rademaker, M. T., & Espiner, E. A. (2002). Cardiovascular hormones. In G. M. Besser & M. O. Thorner (Eds.), Comprehensive Clinical Endocrinology. (3rd ed.) (pp. 485-499). Edinburgh: Mosby.

Rademaker, M. T., & Espiner, E. A. (2001). The endrocrine heart. In K. Becker (Ed.), Principles and Practice of Endocrinology and Metabolism (3rd edition). (pp. 1622-1634). Philadelphia: Lippincott Williams and Wilkins.

Rademaker, M. T., & Espiner, E. A. (2001). Hormones of the cardiovascular system. In L. J. DeGroot & J. L. Jameson (Eds.), Endocrinology. (4th ed.) (pp. 1791-1809). Philadelphia: W. B. Saunders Company.

Espiner, E. A., Richards, A. M., & Nicholls, M. G. (1998). Physiology of natriuretic peptides. In E. R. Levin & J. Nadler (Eds.), Endocrinology of Cardiovascular Function. Kluwer Academic Publishers.

Espiner, E. A. (1997). Physiology of natriuretic peptides. In W. K. Samson & E. R. Levin (Eds.), Natriuretic Peptides in Health and Disease. (Contemporary Endocrinology, 5). (pp. 123-146). Totowa, N.J.: Humana Press.

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Chapter in Book - Other

Espiner, E. (2013). Medical Unit. In P. Joyce, G. Nicholls, K. Thomas & T. Wilkinson (Eds.), The Christchurch experience: 40 years of research and teaching. (pp. 113-116). Christchurch, New Zealand: University of Otago.

Richards, M., Troughton, R., Espiner, E., Cameron, V., Ellmers, L., Pilbrow, A., Charles, C., Rademaker, M., Pemberton, C., & Yandle, T. (2013). Christchurch Heart Institute. In P. Joyce, G. Nicholls, K. Thomas & T. Wilkinson (Eds.), The Christchurch experience: 40 years of research and teaching. (pp. 68-74). Christchurch, New Zealand: University of Otago.

Rademaker, M. T., & Espiner, E. (2010). Hormones of the cardiovascular system. In J. L. Jameson & L. J. De Groot (Eds.), Endocrinology: Adult and pediatric (Vol. II). (6th ed.) (pp. 2036-2052). Philadelphia, PA: Saunders.

Rademaker, M. T., & Espiner, E. A. (2006). Hormones of the cardiovascular system. In L. J. DeGroot & J. L. Jameson (Eds.), Endocrinology (Vol. 3). (5th ed.) (pp. 2549-2566). Philadelphia: Elsevier Saunders.

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Journal - Research Article

Scott, N. J. A., Rademaker, M. T., Charles, C. J., Espiner, E. A., & Richards, A. M. (2019). Hemodynamic, hormonal, and renal actions of phosphodiesterase-9 inhibition in experimental heart failure. JACC, 74(7), 889-901. doi: 10.1016/j.jacc.2019.05.067

Spiroski, A. M., Oliver, M. H., Jaquiery, A. L., Prickett, T. C. R., Espiner, E. A., Harding, J. E., & Bloomfield, F. H. (2018). Postnatal effects of intrauterine treatment of the growth-restricted ovine fetus with intra-amniotic insulin-like growth factor-1. Journal of Physiology, 596(23), 5925-5945. doi: 10.1113/jp274999

Prickett, T. C. R., Darlow, B. A., Troughton, R. W., Cameron, V. A., Elliott, J. M., Martin, J., Horwood, L. J., & Espiner, E. A. (2018). New insights into cardiac and vascular natriuretic peptides: Findings from young adults born with very low birth weight. Clinical Chemistry, 64(2), 363-373. doi: 10.1373/clinchem.2017.280354

Boudin, E., de Jong, T. R., Prickett, T. C. R., Lapauw, B., Toye, K., Van Hoof, V., … Espiner, E. A., … Mortier, G. R. (2018). Bi-allelic loss-of-function mutations in the NPR-C receptor result in enhanced growth and connective tissue abnormalities. American Journal of Human Genetics, 103(2), 288-295. doi: 10.1016/j.ajhg.2018.06.007

Rapley, S. A., Prickett, T. C. R., Dalrymple-Alford, J. C., & Espiner, E. A. (2018). Environmental enrichment elicits a transient rise of bioactive C-Type Natriuretic Peptide in young but not aged rats. Frontiers in Behavioral Neuroscience, 12(142). doi: 10.3389/fnbeh.2018.00142

Wilson, M. O., Barrell, G. K., Prickett, T. C. R., & Espiner, E. A. (2018). Molecular forms of C-type natriuretic peptide in cerebrospinal fluid and plasma reflect differential processing in brain and pituitary tissues. Peptides, 99, 223-230. doi: 10.1016/j.peptides.2017.10.007

Wilson, M. O., McNeill, B. A., Barrell, G. K., Prickett, T. C. R., & Espiner, E. A. (2017). Dexamethasone increases production of C-type natriuretic peptide in the sheep brain. Journal of Endocrinology, 235(1), 15-25. doi: 10.1530/joe-17-0148

Woodward, Z., Prickett, T. C. R., Espiner, E. A., & Anderson, T. J. (2017). Central and systemic C-type Natriuretic Peptide are both reduced in Parkinson's Disease. Parkinsonism & Related Disorders, 43, 15-19. doi: 10.1016/j.parkreldis.2017.06.019

Madhavan, S., Prickett, T. C. R., Espiner, E. A., & Barrell, G. K. (2017). Nutrient restriction in early ovine pregnancy stimulates C-type natriuretic peptide production. Reproduction, Fertility & Development, 29(3), 575-584. doi: 10.1071/RD15192

Prickett, T. C. R., Doughty, R. N., Troughton, R. W., Frampton, C. M., Whalley, G. A., Ellis, C. J., Espiner, E. A., & Richards, A. M. (2017). C-type natriuretic peptides in coronary disease. Clinical Chemistry, 63(1), 316-324. doi: 10.1373/clinchem.2016.257816

Olney, R. C., Salehi, P., Prickett, T. C. R., Lima, J. J., Espiner, E. A., Sikes, K. M., & Geffner, M. E. (2016). Dynamic response of C-type natriuretic peptide and its aminoterminal propeptide (NTproCNP) to growth hormone treatment in children with short stature. Clinical Endocrinology, 85(4), 561-568. doi: 10.1111/cen.13103

Espiner, E. A., Prickett, T. C. R., Taylor, R. S., Reid, R. A., & McCowan, L. M. (2015). Effects of pre-eclampsia and fetal growth restriction on C-type natriuretic peptide. BJOG, 122(9), 1236-1243. doi: 10.1111/1471-0528.13397

Wilson, M. O., Barrell, G. K., Prickett, T. C. R., & Espiner, E. A. (2015). Sustained increases in plasma C-type natriuretic peptides fail to increase concentrations in cerebrospinal fluid: Evidence from pregnant sheep. Peptides, 69, 103-108. doi: 10.1016/j.peptides.2015.04.016

Olney, R. C., Prickett, T. C. R., Espiner, E. A., Mackenzie, W. G., Duker, A. L., Ditro, C., … Bober, M. B. (2015). C-type natriuretic peptide plasma levels are elevated in subjects with achondroplasia, hypochondroplasia, and thanatophoric dysplasia. Journal of Clinical Endocrinology & Metabolism, 100(2), E355-E359. doi: 10.1210/jc.2014-2814

Prickett, T. C. R., Wellby, M., Barrell, G. K., Richards, A. M., & Espiner, E. A. (2014). Differential response of C-type natriuretic peptide to estrogen and dexamethasone in adult bone. Steroids, 87, 1-5. doi: 10.1016/j.steroids.2014.05.007

Espiner, E. A., Dalrymple-Alford, J. C., Prickett, T. C. R., Alamri, Y., & Anderson, T. J. (2014). C-type natriuretic peptide in Parkinson's disease: Reduced secretion and response to deprenyl. Journal of Neural Transmission, 121(4), 371-378. doi: 10.1007/s00702-013-1123-9

Reid, R. A., Prickett, T. C. R., Pullar, B. E., Darlow, B. A., Gullam, J. E., & Espiner, E. A. (2014). C-type natriuretic peptide in complicated pregnancy: Increased secretion precedes adverse events. Journal of Clinical Endocrinology & Metabolism, 99(4), 1470-1478. doi: 10.1210/jc.2013-3758

Hannema, S. E., Duyvenvoorde, H. A., Premsler, T., Yang, R.-B., Mueller, T. D., Gassner, B., … Prickett, T., … Espiner, E. A., … Wit, J. M. (2013). An activating mutation in the kinase homology domain of the natriuretic peptide receptor-2 causes extremely tall stature without skeletal deformities. Journal of Clinical Endocrinology & Metabolism, 98(12), E1988-E1998. doi: 10.1210/jc.2013-2358

Prickett, T. C. R., Hector-Taylor, J., Olney, R. C., Darlow, B. A., & Espiner, E. A. (2013). Acute inflammation in young children inhibits C-type natriuretic peptide. Pediatric Research, 74(2), 191-195. doi: 10.1038/pr.2013.92

Prickett, T. C. R., Olney, R. C., Cameron, V. A., Ellis, M. J., Richards, A. M., & Espiner, E. A. (2013). Impact of age, phenotype and cardio-renal function on plasma C-type and B-type natriuretic peptide forms in an adult population. Clinical Endocrinology, 78(5), 783-789. doi: 10.1111/cen.12035

Olney, R. C., Prickett, T. C. R., Espiner, E. A., & Ross, J. L. (2012). C-Type natriuretic peptide (CNP) levels are altered in boys with Klinefelter syndrome. Journal of Clinical Endocrinology & Metabolism, 97(11), 4206-4211. doi: 10.1210/jc.2012-2598

Reh, C. S., Olney, R. C., Azen, C., Prickett, T. C., Espiner, E. A., & Geffner, M. E. (2012). Plasma C-type natriuretic peptide forms and thyroid status in prepubertal children with acquired thyroid disease. Clinical Endocrinology, 76(2), 228-235. doi: 10.1111/j.1365-2265.2011.04187.x

Prickett, T. C. R., Lyver, A., Wilson, R., Espiner, E. A., & Sullivan, M. J. (2012). C-type natriuretic peptide: A novel biomarker of steroid induced bone toxicity in children with acute lymphoblastic leukemia (ALL). Peptides, 36(1), 54-59. doi: 10.1016/j.peptides.2012.04.017

Olney, R. C., Permuy, J. W., Prickett, T. C. R., Han, J. C., & Espiner, E. A. (2012). Amino-terminal propeptide of C-type natriuretic peptide (NTproCNP) predicts height velocity in healthy children. Clinical Endocrinology, 77(3), 416-422. doi: 10.1111/j.1365-2265.2012.04392.x

McNeill, B. A., Barrell, G. K., Ridgway, M. J., Wellby, M. P., Prickett, T. C. R., & Espiner, E. A. (2012). Caloric restriction, but not caloric loading, affects circulating fetal and maternal C-type natriuretic peptide concentrations in late ovine gestation. Reproduction, Fertility & Development, 24(8), 1063-1070. doi: 10.1071/rd11312

Schouten, B. J., Prickett, T. C., Hunt, P. J., Richards, A. M., Geffner, M. E., Olney, R. C., & Espiner, E. A. (2012). C-type natriuretic peptide forms in adult hyperthyroidism: Correlation with thyroid hormones and markers of bone turnover. Clinical Endocrinology, 76(6), 790-796. doi: 10.1111/j.1365-2265.2011.04295.x

Prickett, T. C. R., Bothwell, J. C., Yandle, T. G., Richards, A. M., & Espiner, E. A. (2011). Pharmacodynamic responses of plasma and tissue C-type natriuretic peptide to GH: Correlation with linear growth in GH-deficient rats. Journal of Endocrinology, 15, 217-225. doi: 10.1530/joe-11-0387

McNeill, B. A., Barrell, G. K., Wooding, F. B. P., Prickett, T. C. R., & Espiner, E. A. (2011). The trophoblast binucleate cell is the source of maternal circulating C-type natriuretic peptide during ovine pregnancy. Placenta, 32(9), 645-650. doi: 10.1016/j.placenta.2011.06.001

Schouten, B. J., Prickett, T. C. R., Hooper, A. A., Hooper, G. J., Yandle, T. G., Richards, A. M., & Espiner, E. A. (2011). Central and peripheral forms of C-type natriuretic peptide (CNP): Evidence for differential regulation in plasma and cerebrospinal fluid. Peptides, 32(4), 797-804. doi: 10.1016/j.peptides.2011.01.013

Prickett, T. C. R., McNeill, B. A., Oliver, M. H., Harding, J. E., & Espiner, E. A. (2010). Effect of cortisol on C-type natriuretic peptide in ovine pregnancy: Differential responses in fetal and placental tissues. Pediatric Research, 68(6), 462-465. doi: 10.1203/PDR.0b013e3181f9039d

Prickett, T. C. R., Ryan, J. F., Wellby, M., Barrell, G. K., Yandle, T. G., Richards, A. M., & Espiner, E. A. (2010). Effect of nutrition on plasma C-type natriuretic peptide forms in adult sheep: Evidence for enhanced C-type natriuretic peptide degradation during caloric restriction. Metabolism, 59(6), 796-801. doi: 10.1016/j.metabol.2009.09.026

Palmer, S. C., Prickett, T. C. R., Espiner, E. A., Yandle, T. G., & Richards, A. M. (2009). Regional release and clearance of C-type natriuretic peptides in the human circulation and relation to cardiac function. Hypertension, 54(3), 612-618. doi: 10.1161/HYPERTENSIONAHA.109.135608

McNeill, B. A., Barrell, G. K., Wellby, M., Prickett, T. C. R., Yandle, T. G., & Espiner, E. A. (2009). C-type natriuretic peptide forms in pregnancy: Maternal plasma profiles during ovine gestation correlate with placental and fetal maturation. Endocrinology, 150(10), 4777-4783. doi: 10.1210/en.2009-0176

Prickett, T. C. R., Charles, C. J., Yandle, T. G., Richards, A. M., & Espiner, E. A. (2009). Skeletal contributions to plasma CNP forms: Evidence from regional sampling in growing lambs. Peptides, 30(12), 2343-2347. doi: 10.1016/j.peptides.2009.07.023

Prickett, T. C. R., Dixon, B., Frampton, C., Yandle, T. G., Richards, A. M., Espiner, E. A., & Darlow, B. A. (2008). Plasma amino-terminal pro C-type natriuretic peptide in the neonate: Relation to gestational age and postnatal linear growth. Journal of Clinical Endocrinology & Metabolism, 93(1), 225-232. doi: 10.1210/jc.2007-1815

Prickett, T. C. R., Barrell, G. K., Wellby, M., Yandle, T. G., Richards, A. M., & Espiner, E. A. (2008). Effect of sex steroids on plasma C-type natriuretic peptide forms: Stimulation by oestradiol in lambs and adult sheep. Journal of Endocrinology, 199(3), 481-487. doi: 10.1677/JOE-08-0267

Olney, R. C., Prickett, T. C. R., Yandle, T. G., Espiner, E. A., Han, J. C., & Mauras, N. (2007). Amino-terminal propeptide of C-type natriuretic peptide and linear growth in children: Effects of puberty, testosterone, and growth hormone. Journal of Clinical Endocrinology & Metabolism, 92(11), 4294-4298. doi: 10.1210/jc.2007-0567

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