Emeritus Professor Eric Espiner, Research, Christchurch Heart Institute

MB ChB MD(Otago) FRACP FRSNZ

Christchurch Heart Institute
Department of Medicine
University of Otago, Christchurch
PO Box 4345
Christchurch 8140
New Zealand

Current Roles

Emeritus Professor

Research Interests

Natriuretic Peptides
C-type Natriuetic Peptide regulation and roles in cardiovascular disorders, fetal and maternal welfare, and linear growth.

Publications

Prickett, T. C. R., Howe, P. R. C., & Espiner, E. A. (2023). Resveratrol-induced suppression of C-type Natriuretic peptide associates with increased vertebral bone density in post-menopausal women. JBMR Plus, 7(5), e10732. doi: 10.1002/jbm4.10732

Prickett, T. C. R., Pearson, J. F., Troughton, R. W., Kennedy, M. A., & Espiner, E. A. (2023). The predictive value of A, B, and C-type natriuretic peptides in people at risk of heart disease: Protocol for a longitudinal observational study. JMIR Research Protocols, 12, e37011. doi: 10.2196/37011

Wagner, B. M., Robinson, J. W., Prickett, T. C. R., Espiner, E. A., Khosla, S., Gaddy, D., … Potter, L. R. (2022). Guanylyl cyclase-B dependent bone formation in mice is associated with youth, increased osteoblasts, and decreased osteoclasts. Calcified Tissue International, 111, 506-518. doi: 10.1007/s00223-022-01014-7

Carroll, R. S., Olney, R. C., Duker, A. L., Coghlan, R. F., Mackenzie, W. G., Ditro, C. P., … Espiner, E. A., Prickett, T. C. R., & Bober, M. B. (2022). Collagen X marker levels are decreased in individuals with achondroplasia. Calcified Tissue International, 111, 66-72. doi: 10.1007/s00223-022-00966-0

Lauffer, P., Boudin, E., van der Kaay, D. C. M., Koene, S., van Haeringen, A., van Tellingen, V., … Prickett, T. C. R., … Espiner, E. A., & van Duyvenvoorde, H. A. (2022). Broadening the spectrum of loss-of-function variants in NPR-C-related extreme tall stature. Journal of the Endocrine Society, 6, 1-11. doi: 10.1210/jendso/bvac019

Prickett, T., Troughton, R., & Espiner, E. (2021). Effect of statin therapy on plasma C-type natriuretic peptides. Heart, Lung & Circulation, 30(Suppl. 2), (pp. S65). doi: 10.1016/j.hlc.2021.05.017

Prickett, T. C. R., Espiner, E. A., Irving, M., Bacino, C., Phillips, III, J. A., Savarirayan, R., … Jeha, G. S. (2021). Evidence of feedback regulation of C-type natriuretic peptide during Vosoritide therapy in Achondroplasia. Scientific Reports, 11(1), 24278. doi: 10.1038/s41598-021-03593-1

Prickett, T. C. R., & Espiner, E. A. (2020). Circulating products of C-type natriuretic peptide and links with organ function in health and disease. Peptides, 132, 170363. doi: 10.1016/j.peptides.2020.170363

Prickett, T. C. R., Troughton, R. W., & Espiner, E. A. (2020). Effect of statin therapy on plasma C-type natriuretic peptides and endothelin-1 in males with and without symptomatic coronary artery disease. Scientific Reports, 10, 7927. doi: 10.1038/s41598-020-64795-7

Espiner, E. A., & Prickett, T. C. R. (2020). New prospects for restoring skeletal growth in mucopolysaccharidoses. Endocrinology, 161(4), 1-3. doi: 10.1210/endocr/bqaa034

Prickett, T. C. R., Lunt, H., Warwick, J., Heenan, H. F., & Espiner, E. A. (2019). Urinary amino-terminal pro-C-type natriuretic peptide: A novel marker of chronic kidney disease in diabetes. Clinical Chemistry, 65(8), 10. doi: 10.1373/clinchem.2019.306910

Prickett, T. C. R., Spittlehouse, J. K., Miller, A. L., Liau, Y., Kennedy, M. A., Cameron, V. A., Pearson, J. F., Boden, J. M., Troughton, R. W., & Espiner, E. A. (2019). Contrasting signals of cardiovascular health among natriuretic peptides in subjects without heart disease. Scientific Reports, 9, 12108. doi: 10.1038/s41598-019-48553-y

Scott, N. J. A., Rademaker, M. T., Charles, C. J., Espiner, E. A., & Richards, A. M. (2019). Hemodynamic, hormonal, and renal actions of phosphodiesterase-9 inhibition in experimental heart failure. JACC, 74(7), 889-901. doi: 10.1016/j.jacc.2019.05.067

Espiner, E., Prickett, T., & Olney, R. (2019). Plasma C-type natriuretic peptide: Emerging applications in disorders of skeletal growth. Hormone Research in Paediatrics, 90(6), 345-357. doi: 10.1159/000496544

Darlow, B. A., Horwood, L. J., Martin, J., & Espiner, E. (2018). Metabolic outcomes in young adults born with very low birthweight (VLBW) compared with controls: Data from the New Zealand 1986 Vlbw cohort. Journal of Paediatrics & Child Health, 54(Suppl. 1), (pp. 16). doi: 10.1111/jpc.13881

Bloomfield, F. H., Harding, J. E., Espiner, E. A., Prickett, T., Jaquiery, A. L., & Oliver, M. H. (2018, August). Potential therapies for fetal growth restriction secondary to placental insufficiency. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Lunt, H., Prickett, T., Warwick, J., Heenan, H., & Espiner, E. (2018). C-type natriuretic peptide as a candidate marker of diabetic kidney disease. Diabetologia, 61(Suppl. 1), (pp. S493). doi: 10.1007/s00125-018-4693-0

Rapley, S. A., Prickett, T. C. R., Dalrymple-Alford, J. C., & Espiner, E. A. (2018). Environmental enrichment elicits a transient rise of bioactive C-Type Natriuretic Peptide in young but not aged rats. Frontiers in Behavioral Neuroscience, 12(142). doi: 10.3389/fnbeh.2018.00142

Boudin, E., de Jong, T. R., Prickett, T. C. R., Lapauw, B., Toye, K., Van Hoof, V., … Espiner, E. A., … Mortier, G. R. (2018). Bi-allelic loss-of-function mutations in the NPR-C receptor result in enhanced growth and connective tissue abnormalities. American Journal of Human Genetics, 103(2), 288-295. doi: 10.1016/j.ajhg.2018.06.007

Spiroski, A. M., Oliver, M. H., Jaquiery, A. L., Prickett, T. C. R., Espiner, E. A., Harding, J. E., & Bloomfield, F. H. (2018). Postnatal effects of intrauterine treatment of the growth-restricted ovine fetus with intra-amniotic insulin-like growth factor-1. Journal of Physiology, 596(23), 5925-5945. doi: 10.1113/jp274999

Prickett, T. C. R., Darlow, B. A., Troughton, R. W., Cameron, V. A., Elliott, J. M., Martin, J., Horwood, L. J., & Espiner, E. A. (2018). New insights into cardiac and vascular natriuretic peptides: Findings from young adults born with very low birth weight. Clinical Chemistry, 64(2), 363-373. doi: 10.1373/clinchem.2017.280354

Wilson, M. O., Barrell, G. K., Prickett, T. C. R., & Espiner, E. A. (2018). Molecular forms of C-type natriuretic peptide in cerebrospinal fluid and plasma reflect differential processing in brain and pituitary tissues. Peptides, 99, 223-230. doi: 10.1016/j.peptides.2017.10.007

Darlow, B., Horwood, L. J., Martin, J., & Espiner, E. (2017, November). Metabolic outcomes in young adults born with very low birthweight (VLBW) compared with controls: Data from the New Zealand 1986 VLBW cohort. Verbal presentation at the Paediatric Society of New Zealand 69th Annual Scientific Meeting, Christchurch, New Zealand.

Wilson, M. O., McNeill, B. A., Barrell, G. K., Prickett, T. C. R., & Espiner, E. A. (2017). Dexamethasone increases production of C-type natriuretic peptide in the sheep brain. Journal of Endocrinology, 235(1), 15-25. doi: 10.1530/joe-17-0148

Woodward, Z., Prickett, T. C. R., Espiner, E. A., & Anderson, T. J. (2017). Central and systemic C-type Natriuretic Peptide are both reduced in Parkinson's Disease. Parkinsonism & Related Disorders, 43, 15-19. doi: 10.1016/j.parkreldis.2017.06.019

Madhavan, S., Prickett, T. C. R., Espiner, E. A., & Barrell, G. K. (2017). Nutrient restriction in early ovine pregnancy stimulates C-type natriuretic peptide production. Reproduction, Fertility & Development, 29(3), 575-584. doi: 10.1071/RD15192

Prickett, T. C. R., Doughty, R. N., Troughton, R. W., Frampton, C. M., Whalley, G. A., Ellis, C. J., Espiner, E. A., & Richards, A. M. (2017). C-type natriuretic peptides in coronary disease. Clinical Chemistry, 63(1), 316-324. doi: 10.1373/clinchem.2016.257816

Prickett, T. C. R., Darlow, B. A., Troughton, R., Elliott, J., Horwood, J., Martin, J., & Espiner, E. A. (2016). New insights into cardiac and vascular natriuretic peptides: Findings from young adults born with very low birth weight. Endocrine Reviews, 37(2, Suppl.), ORO3-1. Retrieved from http://press.endocrine.org/series/endo-meetings

Wilson, M. O., McNeill, B. A., Barrell, G. K., Prickett, T. C. R., & Espiner, E. A. (2016, August). Regulation of C-type natriuretic peptide (CNP) in brain tissues: Generalised response to dexamethasone. Verbal presentation at the Medical Sciences Congress (MedSci), Nelson, New Zealand.

Olney, R. C., Salehi, P., Prickett, T. C. R., Lima, J. J., Espiner, E. A., Sikes, K. M., & Geffner, M. E. (2016). Dynamic response of C-type natriuretic peptide and its aminoterminal propeptide (NTproCNP) to growth hormone treatment in children with short stature. Clinical Endocrinology, 85(4), 561-568. doi: 10.1111/cen.13103

Wilson, M. O., Prickett, T. C. R., Espiner, E. A., & Barrell, G. K. (2015, August-September). Dexamethasone elevates C-type natriuretic peptide (CNP) levels in cerebrospinal fluid and plasma: A dose-response study in sheep. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Prickett, T. C. R., Taylor, R. S., Reid, R. A., McCowan, L. M., & Espiner, E. A. (2015). Impact of vascular stress on C-type natriuretic peptide in nulliparous women developing complications in pregnancy. Endocrine Reviews, 36(2, Suppl.), FRI-088. Retrieved from http://press.endocrine.org/series/endo-meetings

Darlow, B. A., Horwood, L. J., Woodward, L. J., Elliott, J. M., Troughton, R. W., Elder, M. J., Epton, M. J., Stanton, J. D., Swanney, M. P., Keenan, R., Melzer, T. R., McKelvey, V. A., Levin, K., Meeks, M. G., Espiner, E. A., Cameron, V. A., & Martin, J. (2015). The New Zealand 1986 very low birth weight cohort as young adults: Mapping the road ahead. BMC Pediatrics, 15, 90. doi: 10.1186/s12887-015-0413-9

Doughty, R., Espiner, E., Prickett, T., Troughton, R., Frampton, C., Whalley, G., … Richards, M. (2015). C type natriuretic peptide (CNP) in acute coronary syndrome (ACS): Prognostic value and relation to cardiac and renal function at baseline. Heart, Lung & Circulation, 24(Suppl. 2), (pp. S83). doi: 10.1016/j.hlc.2015.04.083

Wilson, M. O., Barrell, G. K., Prickett, T. C. R., & Espiner, E. A. (2015). Sustained increases in plasma C-type natriuretic peptides fail to increase concentrations in cerebrospinal fluid: Evidence from pregnant sheep. Peptides, 69, 103-108. doi: 10.1016/j.peptides.2015.04.016

Espiner, E. A., Prickett, T. C. R., Taylor, R. S., Reid, R. A., & McCowan, L. M. (2015). Effects of pre-eclampsia and fetal growth restriction on C-type natriuretic peptide. BJOG, 122(9), 1236-1243. doi: 10.1111/1471-0528.13397

Olney, R. C., Prickett, T. C. R., Espiner, E. A., Mackenzie, W. G., Duker, A. L., Ditro, C., … Bober, M. B. (2015). C-type natriuretic peptide plasma levels are elevated in subjects with achondroplasia, hypochondroplasia, and thanatophoric dysplasia. Journal of Clinical Endocrinology & Metabolism, 100(2), E355-E359. doi: 10.1210/jc.2014-2814

Olney, R. C., Salehi, P., Prickett, T. C. R., Lima, J., Espiner, E. A., Sikes, K., & Geffner, M. E. (2014). Pharmacokinetics of recombinant human growth hormone (rhGH) and dynamic response of amino-terminal pro C-type natriuretic peptide (NTproCP) in short children. Endocrine Reviews, 35(3, Suppl.), OR53-5. Retrieved from http://press.endocrine.org/series/endo-meetings

Prickett, T. C. R., Wellby, M., Barrell, G. K., Richards, A. M., & Espiner, E. A. (2014). Differential response of C-type natriuretic peptide to estrogen and dexamethasone in adult bone. Steroids, 87, 1-5. doi: 10.1016/j.steroids.2014.05.007

Reid, R. A., Prickett, T. C. R., Pullar, B. E., Darlow, B. A., Gullam, J. E., & Espiner, E. A. (2014). C-type natriuretic peptide in complicated pregnancy: Increased secretion precedes adverse events. Journal of Clinical Endocrinology & Metabolism, 99(4), 1470-1478. doi: 10.1210/jc.2013-3758

Espiner, E. A., Dalrymple-Alford, J. C., Prickett, T. C. R., Alamri, Y., & Anderson, T. J. (2014). C-type natriuretic peptide in Parkinson's disease: Reduced secretion and response to deprenyl. Journal of Neural Transmission, 121(4), 371-378. doi: 10.1007/s00702-013-1123-9

Prickett, T. C. R., Alamri, Y., Anderson, T. J., Dalrymple-Alford, J. C., & Espiner, E. A. (2013). Putative neuroprotective role for C-type natriuretic peptide (CNP) in humans: Monoamine oxidase inhibition (MAOI) prevents decline in CSF NTproCNP in Parkinson's Disease (PD). Endocrine Reviews, 34(3, Suppl.), MON-158. Retrieved from http://press.endocrine.org/series/endo-meetings

Salehi, P., Geffner, M. E., Lima, J., Espiner, E. A., Prickett, T. C., Sikes, K., & Olney, R. C. (2013). Pharmacodynamics of C-type natriuretic peptide (CNP) and its amino-terminal propeptide (NTproCNP) during recombinant human growth hormone treatment in children: A potential biomarker of efficacy. Endocrine Reviews, 34(3, Suppl.), SUN-631. Retrieved from http://press.endocrine.org/series/endo-meetings

Rapley, S. A., Prickett, T. C. R., Dalrymple-Alford, J. C., & Espiner, E. A. (2013). C-type Natriuretic Peptide in prefrontal cortex is associated with learning and memory in rodents. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 31st International Australasian Winter Conference on Brain Research. 31, (pp. 48). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2013copy.html

Espiner, E. (2013). Medical Unit. In P. Joyce, G. Nicholls, K. Thomas & T. Wilkinson (Eds.), The Christchurch experience: 40 years of research and teaching. (pp. 113-116). Christchurch, New Zealand: University of Otago.

Richards, M., Troughton, R., Espiner, E., Cameron, V., Ellmers, L., Pilbrow, A., Charles, C., Rademaker, M., Pemberton, C., & Yandle, T. (2013). Christchurch Heart Institute. In P. Joyce, G. Nicholls, K. Thomas & T. Wilkinson (Eds.), The Christchurch experience: 40 years of research and teaching. (pp. 68-74). Christchurch, New Zealand: University of Otago.

Wilson, M., Barrell, G. K., Espiner, E., Prickett, T., Wellby, M., & Ridgway, M. (2013, August). C-type natriuretic peptide levels in cerebrospinal fluid of sheep are not affected by arousal state. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Madhavan, S., Prickett, T., Ridgway, M., Wellby, M., Espiner, E., & Barrell, G. (2013, August). Nutrient restriction in early ovine pregnancy increases maternal plasma C-type natriuretic peptide concentration: An adaptive response to fetal growth restriction. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Hannema, S. E., Duyvenvoorde, H. A., Premsler, T., Yang, R.-B., Mueller, T. D., Gassner, B., … Prickett, T., … Espiner, E. A., … Wit, J. M. (2013). An activating mutation in the kinase homology domain of the natriuretic peptide receptor-2 causes extremely tall stature without skeletal deformities. Journal of Clinical Endocrinology & Metabolism, 98(12), E1988-E1998. doi: 10.1210/jc.2013-2358

Prickett, T. C. R., Hector-Taylor, J., Olney, R. C., Darlow, B. A., & Espiner, E. A. (2013). Acute inflammation in young children inhibits C-type natriuretic peptide. Pediatric Research, 74(2), 191-195. doi: 10.1038/pr.2013.92

Prickett, T. C. R., Olney, R. C., Cameron, V. A., Ellis, M. J., Richards, A. M., & Espiner, E. A. (2013). Impact of age, phenotype and cardio-renal function on plasma C-type and B-type natriuretic peptide forms in an adult population. Clinical Endocrinology, 78(5), 783-789. doi: 10.1111/cen.12035

Rapley, S., Prickett, T., Harland, B., Perry, B., Dalrymple-Alford, J. C., & Espiner, E. (2012). Time-dependent changes in C-type natriuretic peptide in rat brain produced by enriched environments. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 30th International Australasian Winter Conference on Brain Research. 30, (pp. 49). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2012.html

McNeill, B. A., Barrell, G. K., Ridgway, M. J., Wellby, M. P., Prickett, T. C. R., & Espiner, E. A. (2012). Caloric restriction, but not caloric loading, affects circulating fetal and maternal C-type natriuretic peptide concentrations in late ovine gestation. Reproduction, Fertility & Development, 24(8), 1063-1070. doi: 10.1071/rd11312

Olney, R. C., Prickett, T. C. R., Espiner, E. A., & Ross, J. L. (2012). C-Type natriuretic peptide (CNP) levels are altered in boys with Klinefelter syndrome. Journal of Clinical Endocrinology & Metabolism, 97(11), 4206-4211. doi: 10.1210/jc.2012-2598

Prickett, T. C. R., Olney, R., Cameron, V. A., Ellis, J., Richards, A. M., & Espiner, E. A. (2012). Age dependent changes in CNP in humans: New insights linking skeletal growth and vascular integrity. Proceedings of the Medical Sciences Congress (MedSci). (pp. 50). Retrieved from http://www.medscinz.co.nz/QRW2012%20MedSci%20Abstracts.pdf

Wilson, M. O., Madhavan, S., Wellby, M., Ridgway, M. J., Prickett, T. C. R., Barrell, G. K., & Espiner, E. A. (2012). Central and peripheral changes in C-type natriuretic peptide (CNP) in conscious sheep: Evidence of dynamic fluctuations of CNP in cerebrospinal fluid (CSF) and suppression by acute sedation. Proceedings of the Medical Sciences Congress (MedSci). (pp. 29). Retrieved from http://www.medscinz.co.nz/QRW2012%20MedSci%20Abstracts.pdf

Olney, R. C., Permuy, J. W., Prickett, T. C. R., Han, J. C., & Espiner, E. A. (2012). Amino-terminal propeptide of C-type natriuretic peptide (NTproCNP) predicts height velocity in healthy children. Clinical Endocrinology, 77(3), 416-422. doi: 10.1111/j.1365-2265.2012.04392.x

Prickett, T. C. R., Lyver, A., Wilson, R., Espiner, E. A., & Sullivan, M. J. (2012). C-type natriuretic peptide: A novel biomarker of steroid induced bone toxicity in children with acute lymphoblastic leukemia (ALL). Peptides, 36(1), 54-59. doi: 10.1016/j.peptides.2012.04.017

Prickett, T. C. R., & Espiner, E. A. (2012). C-type natriuretic peptide (CNP) and postnatal linear growth. In V. R. Preedy (Ed.), Handbook of growth and growth monitoring in health and disease. (pp. 2789-2809). New York: Springer. doi: 10.1007/978-1-4419-1795-9

Schouten, B. J., Prickett, T. C., Hunt, P. J., Richards, A. M., Geffner, M. E., Olney, R. C., & Espiner, E. A. (2012). C-type natriuretic peptide forms in adult hyperthyroidism: Correlation with thyroid hormones and markers of bone turnover. Clinical Endocrinology, 76(6), 790-796. doi: 10.1111/j.1365-2265.2011.04295.x

Reh, C. S., Olney, R. C., Azen, C., Prickett, T. C., Espiner, E. A., & Geffner, M. E. (2012). Plasma C-type natriuretic peptide forms and thyroid status in prepubertal children with acquired thyroid disease. Clinical Endocrinology, 76(2), 228-235. doi: 10.1111/j.1365-2265.2011.04187.x

Schouten, B. J., Prickett, T. C., Hunt, P. J., Richards, M., & Espiner, E. A. (2011). CNP forms in adult hyperthyroidism: Correlation with thyroid hormones and markers of bone turnover. Endocrine Reviews, 32(3, Suppl.), P2-109. Retrieved from http://press.endocrine.org/series/endo-meetings

Charles, C. J., Espiner, E. A., Nicholls, M. G., Pemberton, C. J., Troughton, R. W., Yandle, T. G., & Richards, A. M. (2011, September). Cardiac biomarkers: Clinical utility for diagnosis, prognosis and guiding treatment of cardiovascular disease. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Madhavan, S., Prickett, T., Lee, R., Green, M., Sedcole, R., Espiner, E., & Barrell, G. (2011, August). C-Type natriuretic peptides are putative indicators of pregnancy viability in cows. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Hooper, G., Schouten, B., Prickett, T., Hooper, A., Yandle, T., & Espiner, E. (2011). C-type natriuretic peptide: A predictor of spinal cord healing? Proceedings of the New Zealand Orthopaedic Association (NZOA) and Australian Orthopaedic Association (AOA) Combined Annual Scientific Meeting: Orthopaedic Education: The E-future. Retrieved from http://www.aoanzoa2011.co.nz/

Prickett, T. C. R., Bothwell, J. C., Yandle, T. G., Richards, A. M., & Espiner, E. A. (2011). Pharmacodynamic responses of plasma and tissue C-type natriuretic peptide to GH: Correlation with linear growth in GH-deficient rats. Journal of Endocrinology, 15, 217-225. doi: 10.1530/joe-11-0387

McNeill, B. A., Barrell, G. K., Wooding, F. B. P., Prickett, T. C. R., & Espiner, E. A. (2011). The trophoblast binucleate cell is the source of maternal circulating C-type natriuretic peptide during ovine pregnancy. Placenta, 32(9), 645-650. doi: 10.1016/j.placenta.2011.06.001

Schouten, B. J., Prickett, T. C. R., Hooper, A. A., Hooper, G. J., Yandle, T. G., Richards, A. M., & Espiner, E. A. (2011). Central and peripheral forms of C-type natriuretic peptide (CNP): Evidence for differential regulation in plasma and cerebrospinal fluid. Peptides, 32(4), 797-804. doi: 10.1016/j.peptides.2011.01.013

Prickett, T. C. R., Espiner, E. A., Richards, A. M., Yandle, T. G., & Nicholls, M. G. (2011). Assessment of skeletal growth using measurements of NT-CNP peptides. (US 7,919,255).

Prickett, T. C. R., Bothwell, J. C., Yandle, T. G., Richards, A. M., & Espiner, E. A. (2010). Pharmacodynamic responses of C-type natriuretic peptide to GH in growth hormone deficient rats: Correlation with linear growth. Endocrine Reviews, 31(3, Suppl. 1), (pp. S1948). [Abstract]

Prickett, T. C. R., McNeill, B. A., Oliver, M. H., Harding, J. E., & Espiner, E. A. (2010). Increased fetal cortisol reduces fetal but not maternal plasma NTproCNP in late ovine gestation. Endocrine Reviews, 31(3, Suppl. 1), (pp. S396). [Abstract]

Olney, R. C., Prickett, T. C., Espiner, E. A., & Ross, J. L. (2010). C-type natriuretic peptide (CNP) levels are altered in boys with Klinefelter syndrome. Endocrine Reviews, 31(3, Suppl. 1), (pp. S752). [Abstract]

Prickett, T. C. R., McNeill, B. A., Oliver, M. H., Harding, J. E., & Espiner, E. A. (2010). Effect of cortisol on C-type natriuretic peptide in ovine pregnancy: Differential responses in fetal and placental tissues. Pediatric Research, 68(6), 462-465. doi: 10.1203/PDR.0b013e3181f9039d

McNeill, B. A., Prickett, T. C. R., Wellby, M., Ridgway, M. J., Espiner, E. A., & Barrell, G. K. (2010). Circulating levels of C-type natriuretic peptide (CNP) are strongly linked to pregnancy but not to liveweight change in ruminants. Proceedings of the New Zealand Society of Animal Production. 70, (pp. 13-18). [Full Paper]

Rademaker, M. T., & Espiner, E. (2010). Hormones of the cardiovascular system. In J. L. Jameson & L. J. De Groot (Eds.), Endocrinology: Adult and pediatric (Vol. II). (6th ed.) (pp. 2036-2052). Philadelphia, PA: Saunders.

Prickett, T. C. R., Ryan, J. F., Wellby, M., Barrell, G. K., Yandle, T. G., Richards, A. M., & Espiner, E. A. (2010). Effect of nutrition on plasma C-type natriuretic peptide forms in adult sheep: Evidence for enhanced C-type natriuretic peptide degradation during caloric restriction. Metabolism, 59(6), 796-801. doi: 10.1016/j.metabol.2009.09.026

Southern Reh, C. M., Azen, C., Espiner, E. A., Olney, R. C., Prickett, T. C., May, J. A., & Geffner, M. E. (2009). Plasma C-type natriuretic peptide forms in pre-pubertal children with acquired thyroid disease: Correlation with thyroid status and height velocity. Hormone Research, 72(Suppl. 3), (pp. 457). doi: 10.1159/000239668

Olney, R. C., Permuy, J. W., Prickett, T. C. R., & Espiner, E. A. (2009). Amino-terminal propeptide of C-type natriuretic peptide (NTproCNP): Levels in healthy children and relation to growth velocity. Hormone Research, 72(Suppl. 3), (pp. 279-280). doi: 10.1159/000239668

Olney, R. C., Prickett, T. C. R., Espiner, E. A., Arn, P. H., Upp, H. L. H., Zerah, M. M., & Dietz, III, H. P. (2009). Is C-type natriuretic peptide (CNP) production elevated in Marfan syndrome? Hormone Research, 72(Suppl. 3), (pp. 279). doi: 10.1159/000239668

Prickett, T. C. R., Charles, C. J., Yandle, T. G., Richards, A. M., & Espiner, E. A. (2009). Skeletal contributions to plasma CNP forms: Evidence from regional sampling in growing lambs. Peptides, 30(12), 2343-2347. doi: 10.1016/j.peptides.2009.07.023

Southern Reh, C. M., Azen, C., Espiner, E. A., Olney, R. C., Prickett, T. C., May, J. A., & Geffner, M. E. (2009). Plasma CNP forms in prepubertal children with acquired thyroid disease: Correlation with thyroid status and bone-specific alkaline phosphatase. Proceedings of the Endocrine Society's 91st Annual Meeting. Retrieved from http://www.abstracts2view.com/endo/

Prickett, T. C., Charles, C. J., Yandle, T. G., Richards, A. M., & Espiner, E. A. (2009). Regional sampling and effects of glucocorticoids: Differential responses in A, B and C-type natriuretic peptides in growing lambs. Proceedings of the Endocrine Society's 91st Annual Meeting. Retrieved from http://www.abstracts2view.com/endo/

McNeill, B. A., Barrell, G. K., Wellby, M., Prickett, T. C. R., Yandle, T. G., & Espiner, E. A. (2009). C-type natriuretic peptide forms in pregnancy: Maternal plasma profiles during ovine gestation correlate with placental and fetal maturation. Endocrinology, 150(10), 4777-4783. doi: 10.1210/en.2009-0176

Palmer, S. C., Prickett, T. C. R., Espiner, E. A., Yandle, T. G., & Richards, A. M. (2009). Regional release and clearance of C-type natriuretic peptides in the human circulation and relation to cardiac function. Hypertension, 54(3), 612-618. doi: 10.1161/HYPERTENSIONAHA.109.135608

McNeill, B. A., Barrell, G. K., Wellby, M., Prickett, T. C., Yandle, T. G., & Espiner, E. A. (2008, November). Sustained elevation of circulating maternal CNP forms in pregnant ewes and red deer hinds: A Longitdinal study. Verbal presentation at the Medical Sciences Congress, Queenstown, New Zealand.

Prickett, T. C. R., Dixon, B., Frampton, C., Yandle, T. G., Richards, A. M., Espiner, E. A., & Darlow, B. A. (2008). Plasma amino-terminal pro C-type natriuretic peptide in the neonate: Relation to gestational age and postnatal linear growth. Journal of Clinical Endocrinology & Metabolism, 93(1), 225-232. doi: 10.1210/jc.2007-1815

Prickett, T. C. R., Barrell, G. K., Wellby, M., Yandle, T. G., Richards, A. M., & Espiner, E. A. (2008). Effect of sex steroids on plasma C-type natriuretic peptide forms: Stimulation by oestradiol in lambs and adult sheep. Journal of Endocrinology, 199(3), 481-487. doi: 10.1677/JOE-08-0267

Darlow, B., Dixon, B., Prickett, T., Frampton, C., Yandle, T., & Espiner, E. (2007). Nt-pro-CNP: A novel marker of linear growth in neonates. Proceedings of the Pediatric Academic Societies Annual Meeting. E-PAS2007:617925. Retrieved from http://www.abstracts2view.com/pasall/view.php?nu=PAS07L1_469

Prickett, T. C., Dixon, B., Frampton, C., Yandle, T. G., Espiner, E. A., & Darlow, B. A. (2007, June). Circulating concentrations of aminoterminal pro C-type natriuretic peptide in the neonate: Effects of gestation, maternal steroids and relation to growth velocity. Verbal presentation at the Endocrine Society's 89th Annual Meeting, Toronto, Canada.

Prickett, T. C., Rumball, C., Yandle, T. G., Harding, J. E., & Espiner, E. A. (2007, June). CNP forms in the ovine fetal and maternal circulation: Evidence for independent regulation and reciprocal response to undernutrition. Poster session presented at the Endocrine Society's 89th Annual Meeting, Toronto, Canada.

Olney, R. C., Prickett, T. C. R., Yandle, T. G., Espiner, E. A., Han, J. C., & Mauras, N. (2007, June). Amino-terminal propeptide of C-type natriuretic peptide (NT-proCNP) correlates with growth velocity in children: Effects of puberty and growth hormone. Poster session presented at the Endocrine Society's 89th Annual Meeting, Toronto, Canada.

Prickett, T. C. R., Rumball, C. W. H., Buckley, A. J., Bloomfield, F. H., Yandle, T. G., Harding, J. E., & Espiner, E. A. (2007). C-type natriuretic peptide forms in the ovine fetal and maternal circulations: Evidence for independent regulation and reciprocal response to undernutrition. Endocrinology, 148(8), 4015-4022.

Prickett, T. C. R., Barrell, G. K., Wellby, M., Yandle, T. G., Richards, A. M., & Espiner, E. A. (2007). Response of plasma CNP forms to acute anabolic and catabolic interventions in growing lambs. American Journal of Physiology: Endocrinology & Metabolism, 292, E1395-E1400. doi: 10.1152/ajpendo.00469.2006

Espiner, E. A., Prickett, T. C., Yandle, T. G., Barrell, G. K., Wellby, M., Sullivan, M. J., & Darlow, B. A. (2007). ABCs of natriuretic peptides: Growth. Hormone Research, 67(Suppl. 1), 81-90.

Dixon, B., Prickett, T., Frampton, C., Yandle, T., Espiner, E., & Darlow, B. (2007). Relationship of a novel peptide, NT-proCNP, and linear growth in neonates. Journal of Paediatrics & Child Health, 43(Suppl. 1), (pp. A51). doi: 10.1111/j.1440-1754.2007.01097.x

Olney, R. C., Prickett, T. C. R., Yandle, T. G., Espiner, E. A., Han, J. C., & Mauras, N. (2007). Amino-terminal propeptide of C-type natriuretic peptide and linear growth in children: Effects of puberty, testosterone, and growth hormone. Journal of Clinical Endocrinology & Metabolism, 92(11), 4294-4298. doi: 10.1210/jc.2007-0567

Prickett, T. C. R., Lynn, A. M., Wellby, M., Barrell, G. K., Darlow, B. A., Espiner, E. A., Richards, A. M., & Yandle, T. G. (2006). Amino-terminal proCNP: A putative marker of growthplate activity in post natal growth. New Zealand Medical Journal, 119(1231). Retrieved from http://journal.nzma.org.nz/journal/119-1231/1922/content.pdf

Richards, M., Nicholls, M. G., Espiner, E. A., Lainchbury, J. G., Troughton, R. W., Elliott, J., Frampton, C. M., Crozier, I. G., Yandle, T. G., … for the Christchurch Cardioendocrine Research Group and the Australia-New Zealand Heart Failure Group. (2006). Comparison of B-type natriuretic peptides for assessment of cardiac function and prognosis in stable ischemic heart disease. JACC, 47(1), 52-60. doi: 10.1016/j.jacc.2005.06.085

Olney, R. C., Bükülmez, H., Bartels, C. F., Prickett, T. C. R., Espiner, E. A., Potter, L. R., & Warman, M. L. (2006). Heterozygous mutations in natriuretic peptide receptor-B (NPR2) are associated with short stature. Journal of Clinical Endocrinology & Metabolism, 91(4), 1229-1232.

Rademaker, M. T., & Espiner, E. A. (2006). Hormones of the cardiovascular system. In L. J. DeGroot & J. L. Jameson (Eds.), Endocrinology (Vol. 3). (5th ed.) (pp. 2549-2566). Philadelphia: Elsevier Saunders.

Charles, C. J., Prickett, T. C. R., Espiner, E. A., Rademaker, M. T., Richards, A. M., & Yandle, T. G. (2006). Regional sampling and the effects of experimental heart failure in sheep: Differential responses in A, B and C-type natriuretic peptides. Peptides, 27(1), 62-68. doi: 10.1016/j.peptides.2005.06.019

Prickett, T., Darlow, B., Lynn, A. M., Barrell, G., Cameron, V., Espiner, E., Richards, M., & Yandle, T. (2005). Amino-terminal proCNP (NT-CNP): A putative marker of growth plate activity. Proceedings of the Perinatal Society of Australia and New Zealand 9th Annual Congress. (pp. P129). [Abstract]

Prickett, T. C. R., Lynn, A. M., Barrell, G. K., Darlow, B. A., Cameron, V. A., Espiner, E. A., Richards, A. M., & Yandle, T. G. (2005). Amino-terminal proCNP: A putative marker of cartilage activity in postnatal growth. Pediatric Research, 58(2), 334-340.

Rademaker, M. T., Charles, C. J., Espiner, E. A., Frampton, C. M., Lainchbury, J. G., & Richards, A. M. (2005). Endogenous urocortins reduce vascular tone and renin-aldosterone / endothelin activity in experimental heart failure. European Heart Journal, 26(19), 2046-2054. doi: 10.1093/eurheartj/ehi227

Rademaker, M. T., Charles, C. J., Espiner, E. A., Frampton, C. M., Lainchbury, J. G., & Richards, A. M. (2005). Four-day urocortin-I administration has sustained beneficial haemodynamic, hormonal, and renal effects in experimental heart failure. European Heart Journal, 26, 2055-2062. doi: 10.1093/eurheartj/ehi351

Prickett, T. C. R., Barrell, G. K., Wellby, M., Lynn, A. M., Kaaja, R. J., Cameron, V. A., Espiner, E. A., Richards, A. M., & Yandle, T. G. (2004). Plasma amino-terminal proCNP: A putative marker of growth plate activity. Journal of Bone & Mineral Research, 19(Suppl. 1), (pp. S348). doi: 10.1002/jbmr.5650191306

Richards, A. M., Lainchbury, J. G., Troughton, R. W., Espiner, E. A., & Nicholls, M. G. (2004). Clinical applications of B-type natriuretic peptides. Trends in Endocrinology & Metabolism, 15(4), 170-174.

Rademaker, M., Charles, C., Espiner, E., Lainchbury, J., Nicholls, G., & Richards, M. (2004). Chronic urocortin administration in experimental heart failure. Proceedings of the 12^th International Congress of Endocrinology. (pp. 174-175). [Abstract]

Prickett, T. C., Kaaja, R. J., Nicholls, M. G., Espiner, E. A., Richards, A. M., & Yandle, T. G. (2004). N-terminal pro-C-type natriuretic peptide, but not C-type natriuretic peptide, is greatly elevated in the fetal circulation. Clinical Science, 106(5), 535-540.

Yandle, T., Fisher, S., Livesey, J., Espiner, E., Richards, M., & Nicholls, G. (2004). Exponential increase in clinical use of plasma brain natriuretic peptide (BNP) assays. New Zealand Medical Journal, 117(1197). Retrieved from http://journal.nzma.org.nz/journal/117-1197/956/content.pdf

Rademaker, M. T., Charles, C. J., Espiner, E. A., Frampton, C. M., Nicholls, M. G., & Richards, A. M. (2004). Combined inhibition of angiotensin II and endothelin suppresses the brain natriuretic peptide response to developing heart failure. Clinical Science, 106, 569-576.

Troughton, R. W., Frampton, C. M., Yandle, T. G., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (2003). Plasma amino-terminal B-type natriuretic peptide measured by Elecsys 2010 assay in a trial of hormone-guided treatment for heart failure. Clinical Chemistry, 49(7), 1212-1215.

Richards, A. M., Nicholls, M. G., Espiner, E. A., Lainchbury, J. G., Troughton, R. W., Elliott, J., Frampton, C., Turner, J., Crozier, I. G., & Yandle, T. G. (2003). B-type natriuretic peptides and ejection fraction for prognosis after myocardial infarction. Circulation, 107(22), 2786-2792. doi: 10.1161/01.CIR.0000070953.76250.B9

Espiner, E. A., Ross, D., Yandle, T. G., Richards, A. M., & Hunt, P. J. (2003). Predicting surgically remedial primary aldosteronism: Role of adrenal scanning, posture testing, and adrenal vein sampling. Journal of Clinical Endocrinology & Metabolism, 88(8), 3637-3644.

Manning, P. J., Espiner, E. A., Yoon, K., Drury, P. L., Holdaway, I. M., & Bowers, A. J. (2003). An unusual cause of hyperinsulinaemic hypoglycaemia syndrome. Diabetic Medicine, 20, 772-776.

Rademaker, M. T., Charles, C. J., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (2002, November). Chronic adrenomedullin administration in experimental heart failure. Verbal presentation at the 3rd International Symposium on Adrenomedullin and PAMP, Osaka, Japan.

Rademaker, M. T., Charles, C. J., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (2002). hronic adrenomedullin administration in experimental heart failure. Verbal presentation at the 3rd International Symposium on Adrenomedullin and PAMP, Osaka, Japan.

Pemberton, C. J., Yandle, T. G., & Espiner, E. A. (2002). Immunoreactive forms of natriuretic peptides in ovine brain: Response to heart failure. Peptides, 23(12), 2235-2244.

Rademaker, M. T., Charles, C. J., Espiner, E. A., Fisher, S., Frampton, C. M., Kirkpatrick, C., Lainchbury, J. G., Nicholls, M. G., & Richards, A. M. (2002). Urocortin has beneficial hemodynamic, endocrine and renal effects in experimental heart failure. Abstracts presented at the Joint Meeting of the 19th Scientific Meeting of the International Society of Hypertension and the 12th European Meeting on Hypertension. 20(supplement), (pp. P1300). Prague, Czech Republic: Lippincott Williams & Wilkins Healthcare. [Abstract]

McGeoch, G. R. B., Lainchbury, J. G., Town, G. I., Toop, L. J., Espiner, E. A., & Richards, A. M. (2002). Plasma brain natriuretic peptide after long-term treatment for heart failure in general practice. European Journal of Heart Failure, 4(4), 479-483.

Rademaker, M. T., Charles, C. J., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (2002). Long-Term adrenomedullin administration in experimental heart failure. Hypertension, 40(5), 667-672.

Rademaker, M. T., & Espiner, E. A. (2002). Cardiovascular hormones. In G. M. Besser & M. O. Thorner (Eds.), Comprehensive Clinical Endocrinology. (3rd ed.) (pp. 485-499). Edinburgh: Mosby.

Rademaker, M. T., Charles, C. J., Espiner, E. A., Fisher, S., Frampton, C. M., Kirkpatrick, C. M. J., Lainchbury, J. G., Nicholls, M. G., Richards, A. M., & Vale, W. W. (2002). Beneficial hemodynamic, endocrine, and renal effects of urocortin in experimental heart failure: Comparison with normal sheep. JACC, 40(8), 1495-1505.

Rademaker, M. T., Charles, C. J., Cooper, G. J. S., Coy, D. H., Espiner, E. A., Lewis, L. K., Nicholls, M. G., & Richards, A. M. (2002). Combined endopeptidase inhibition and adrenomedullin in sheep with experimental heart failure. Hypertension, 39(1), 93-98.

Rademaker, M. T., Charles, C. J., Cooper, G. J. S., Coy, D. H., Espiner, E. A., Lewis, L. K., Nicholls, M. G., & Richards, A. M. (2002). Combined angiotensin-converting enzyme inhibition and adrenomedullin in an ovine model of heart failure. Clinical Science, 102(6), 653-660.

Richards, A. M., Nicholls, M. G., Troughton, R. W., Lainchbury, J. G., Elliott, J., Frampton, C., Espiner, E. A., Crozier, I. G., Yandle, T. G., & Turner, J. (2002). Antecedent hypertension and heart failure after myocardial infarction. JACC, 39(7), 1182-1188. doi: 10.1016/S0735-1097(02)01737-0

Espiner, E. A., Leikis, R., Ferch, R. D., MacFarlane, M. R., Bonkowski, J. A., Frampton, C. M., & Richards, A. M. (2002). The neuro-cardio-endocrine response to acute subarachnoid haemorrhage. Clinical Endocrinology, 56(5), 629-635.

Cameron, V. A., Autelitano, D. J., Evans, J. J., Ellmers, L. J., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (2002). Adrenomedullin expression in rat uterus is correlated with plasma estradiol. American Journal of Physiology: Endocrinology & Metabolism, 282, E139-E146.

Rademaker, M. T., Charles, C. J., Lewis, L. K., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (2001). Combined adrenomedullin adminstration and angiotensin-converting enzyme inhibition in experimental heart failure. Verbal presentation at the 34th International Congress of Physiological Sciences, Christchurch.

Espiner, E. A., Cameron, A. V., Charles, C., Nicholls, M. G., Rademaker, M. T., Richards, A. M., & Yandle, T. (2001). The endocrine heart. Proceedings of the New Zealand Endocrine Society Annual Meeting. (pp. A43). [Abstract]

Rademaker, M. T., Charles, C. J., Espiner, E. A., Lewis, L. K., Nicholls, M. G., & Richards, A. M. (2001, August). Combined adrenomedullin administration and angiotensin-converting enzyme inhibition in experimental heart failure. Verbal presentation at the 34th International Congress of Physiological Sciences, Christchurch, New Zealand.

Richards, A. M., Nicholls, M. G., Espiner, E. A., Troughton, R. W., Lainchbury, J. G., Elliott, J. M., Crozier, I. G., Frampton, C. M., Turner, J. G., & Yandle, T. G. (2001). Superiority of plasma aminoterminal BNP over left ventricular ejection fraction for prognosis after myocardial infarction. European Heart Journal. 22(210A). [Full Paper]

Rademaker, M. T., & Espiner, E. A. (2001). Hormones of the cardiovascular system. In L. J. DeGroot & J. L. Jameson (Eds.), Endocrinology. (4th ed.) (pp. 1791-1809). Philadelphia: W. B. Saunders Company.

Rademaker, M. T., & Espiner, E. A. (2001). The endrocrine heart. In K. Becker (Ed.), Principles and Practice of Endocrinology and Metabolism (3rd edition). (pp. 1622-1634). Philadelphia: Lippincott Williams and Wilkins.

Richards, A. M., Doughty, R. N., Nicholls, M. G., MacMahon, S., Sharpe, N., Murphy, J., Espiner, E. A., Frampton, C. M., & Yandle, T. G. (2001). Plasma N-terminal pro-brain natriuretic peptide and adrenomedullin: Prognostic utility and prediction of benefit from carvedilol in chronic ischemic left ventricular dysfunction. JACC, 37(7), 1781-1787.

Cameron, V. A., Cumming, S. A., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (2001). C-type natriuretic peptide expression in olfactory regions of rat brain is modulated by acute water deprivation, salt loading and central angiotensin II. Neuroendocrinology, 73, 46-53.

Richards, A. M., Nicholls, M. G., Troughton, R. W., Lainchbury, J. G., Frampton, C. M., Espiner, E. A., Ikram, H., Yandle, T. G., & Turner, J. G. (2001). Antecedent hypertension and risk of heart failure after myocardial infarction. Journal of the American College of Cardiology. 37(2 Supplement A), (pp. 869-5). [Abstract]

Prickett, T., Yandle, T. G., Nicholls, M. G., Espiner, E. A., & Richards, A. M. (2001). Identification of amino-terminal pro-C-type natriuretic peptide in human plasma. Biochemical & Biophysical Research Communications, 286(3), 513-517.

Aitken, G. D., Cameron, V. A., Rademaker, M. T., Charles, C. J., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (2001). Increased atrial but not ventricular ANP and BNP expression in a paced model of heart failure. Journal of Biochemistry, Molecular Biology & Biophysics, 5, 199-207.

Troughton, R. W., Frampton, C. M., Yandle, T. G., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (2000). Treatment of heart failure guided by plasma aminoterminal brain natriuretic peptide (N-BNP) concentrations. Lancet, 355(9210), 1126-1130. doi: 10.1016/S0140-6736(00)02060-2

Rademaker, M. T., Charles, C. J., Cooper, G. J. S., Coy, D. H., Espiner, E. A., Lewis, L. K., Nicholls, M. G., Pemberton, C. J., & Richards, A. M. (2000, October). Combined adrenomedullin administration and neutral endopeptidase inhibitor in heart failure. Verbal presentation at the 4th Annual Meeting of the Society for Cardiovascular Endocrinology and Metabolism, Australia.

Cameron, A. V., Autelitano, D. J., Evans, J. J., Ellmers, L. J., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (2000, October). Adrenomedullin expression in rat uterus is correlated positively with plasma oestradiol and inversely with plasma progesterone. Verbal presentation at the Eleventh International Congress of Endocrinology, Sydney, Australia.

Rademaker, M. T., Charles, C. J., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (2000, October/November). Combined adrenomedullin administration and neutral endopeptidase inhibition in heart failure. Verbal presentation at the 11 th International Congress of Endocrinology, Sydney.

Pemberton, C. J., Johnson, M. L., Yandle, T. G., & Espiner, E. A. (2000). Deconvolution analysis of cardiac natriuretic peptides during acute volume overload. Hypertension, 36(3), 355-359.

Smith, M. W., Espiner, E. A., Yandle, T. G., Charles, C. J., & Richards, A. M. (2000). Delayed metabolism of human brain natriuretic peptide reflects resistance to neutral endopeptidase. Journal of Endocrinology, 167(2), 239-246.

Florkowski, C. M., Barnard, R., Veveris, T., Livesey, J. L., Espiner, E. A., & Donald, R. A. (2000). The effect of growth-hormone binding protein, leptin and parameters of body composition in growth-hormone treated hypopituitary adults. International Journal of Obesity, 24, 160-161.

Ellmers, L. J., Knowles, J., Smithies, O., Nicholls, M. G., Espiner, E. A., Richards, A. M., & Cameron, V. A. (2000). Atrial natriuretic peptide and brain natriuretic peptide gene expression in natriuretic peptide receptor-A deficient mice. Proceedings of the 4th Annual Meeting of the Society for Cardiovascular Endocrinology and Metabolism. (pp. A7). Palm Cove, Queensland. [Abstract]

Troughton, R. W., Rademaker, M. T., Powell, J. D., Yandle, T. G., Espiner, E. A., Frampton, C. M., Nicholls, M. G., & Richards, A. M. (2000). Beneficial renal and hemodynamic effects of omapatrilat in mild and severe heart failure. Hypertension, 36(4), 523-530.

Rademaker, M. T., Cameron, V. A., Charles, C. J., Espiner, E. A., Nicholls, M. G., Pemberton, C. J., & Richards, A. M. (2000). Neurohormones in an ovine model of compensated post-infarction left ventricular dysfunction. American Journal of Physiology: Heart & Circulatory Physiology, 278, H731-H740.

Snowdon, J. A., Hill, G. R., Hunt, P. J., Carnoutsos, S. A., Spearing, R. L., Espiner, E. A., & Hart, D. (2000). Assessment of cardiotoxicity during haemopoietic stem cell transplantation with plasma brain natriuretic peptide. Bone Marrow Transplantation, 26(3), 309-313.

Cameron, V. A., Rademaker, M. T., Ellmers, L. J., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (2000). Atrial (ANP) and brain natriuretic peptide (BNP) expression after myocardial infarction in sheep: ANP is synthesized by fibroblasts infiltrating the infarct. Endocrinology, 141(12), 4690-4697. doi: 10.1210/endo.141.12.7847

Rademaker, M. T., Troughton, R. W., Charles, C. J., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (1999, August). Acute and chronic administration of Omapatrilat in an ovine model of mild and severe heart failure. Verbal presentation at the 2nd BCCH Symposium, Sydney, Australia.

Rademaker, M. T., Troughton, R. W., Charles, C. J., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (1999). Acute and chronic administration of omapatrilat in an ovine model of mild and severe heart failure. Verbal presentation at the 47th Annual Meeting Cardiac Society of Australia and New Zealand, Wellington, New Zealand.

Cameron, A. V., Rademaker, M. T., Ellmers, L. J., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (1999). Comparison of atrial and brain natriuretic peptide expression in ovine heart after myocardial infarction. Verbal presentation at the 2nd BCCH Symposium, Sydney, Australia.

Pemberton, C. J., Johnson, M., Yandle, T. G., & Espiner, E. A. (1999). The in vivo Half-life of NT-ProBNP is 14-fold Longer Than Mature BNP in Ovine Plasma. In A. Zanchetti & G. Mancia (Eds.), Ninth European Meeting on Hypertension - Abstracts. 9, (pp. S55-S56). Hagerstown, United States of America: International Society of Hypertension. [Full Paper]

Lainchbury, J. G., Richards, A. M., Nicholls, M. G., Espiner, E. A., & Yandle, T. G. (1999). Brain natriuretic peptide and neutral endopeptidase inhibition in left ventricular impairment. Journal of Clinical Endocrinology & Metabolism, 84(2), 723-729. doi: 10.1210/jcem.84.2.5489

Lainchbury, J. G., Troughton, R. W., Lewis, L. K., Yandle, T. G., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (1999). Low and high dose adrenomedullin infusion in normal volunteers. 72nd Scientific Sessions, American Heart Foundation. 100(18), (pp. I-350). Circulation. [Abstract]

Richards, A. M., Doughty, R. N., Nicholls, M. G., MacMahon, S., Ikram, H., Sharpe, N., Espiner, E. A., Frampton, C. M., & Yandle, T. G. (1999). Neurohumoral prediction of benefit from carvedilol in ischemic left ventricular dysfunction. Circulation, 99(6), 786-792.

Seidler, T., Pemberton, C. J., Yandle, T. G., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (1999). The amino terminal regions of proBNP and proANP: Oligomerise through leucine zipper-like coiled-coil motifs. Biochemical & Biophysical Research Communications, 255, 495-501.

Yandle, T. G., Fisher, S., Espiner, E. A., Richards, A. M., & Nicholls, M. G. (1999). Validating aminoterminal BNP assays: a word of caution. Lancet, 353(9158), 1068-1069.

Charles, C. J., Espiner, E. A., Nicholls, M. G., Rademaker, M. T., & Richards, A. M. (1999). Bioactivity of natriuretic peptide coinfusions: no evidence for unique effects of BNP in conscious sheep. Journal of Cardiovascular Pharmacology, 33(2), 229-236.

Florkowski, C. M., Barnard, R., Livesey, J. H., Veveris, T., Espiner, E. A., & Donald, R. A. (1999). Growth hormone binding protein correlates strongly with leptin and percentage body fat in GH-deficient adults, is increased by GH replacement but does not predict IGF-I response. Growth Hormone & IGF Research, 1, 35-40.

Richards, A. M., Nicholls, M. G., Yandle, T. G., Ikram, H., Espiner, E. A., Turner, J. G., … Lainchbury, J. G., Elliott, J. M., Frampton, C. M., Crozier, I. G., & Smyth, D. W. (1999). Neuroendocrine prediction of left ventricular function and heart failure after acute myocardial infarction. Heart, 81, 114-120.

Troughton, R. W., Rademaker, M. T., Charles, C. J., Espiner, E. A., & Nicholls, M. G. (1999). Acute and chronic administration of Omapatrilat in an ovine model in mild and severe heart failure. 72nd Scientific Sessions, American Heart Foundation. (pp. I-300). [Abstract]

Aitken, G. D., Raizis, A. M., Yandle, T. G., George, P. M., Espiner, E. A., & Cameron, V. A. (1999). The characerization of ovine genes for atrial, brain, and C-type natriuretic peptides. Domestic Animal Endocrinology, 16(2), 115-121. doi: 10.1016/S0739-7240(99)00005-3

Lainchbury, J. G., Nicholls, M. G., Espiner, E. A., Yandle, T. G., Lewis, L. K., & Richards, A. M. (1999). Bioactivity and interactions of adrenomedullin and brain natriuretic peptide in patients with heart failure. Hypertension, 34(1), 70-75.

Cameron, A. V., Rademaker, M. T., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (1999). Regional and temporal comparison of atrial and brain natriuretic peptide gene expression in an ovine model of myocardial infarction. 1st International Congress on Heart Disease - New Trends in Research, Diagnosis and Treatment. 1(1). The Journal of Heart Disease. [Abstract]

Elliott, J. M., Smyth, D. W., Lainchbury, J. G., Tisch, J., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (1998). Correlations between atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and left ventricular ejection fraction (LVEF) after direct angioplasty (PTCA) or thrombolysis (TS) in acute anterior myocardial infarction (AMI). Australian and New Zealand Journal of Medicine. 28, (pp. 139). [Abstract]

Lainchbury, J. G., Richards, A. M., Nicholls, M. G., Espiner, E. A., & Yandle, T. G. (1998). Effects of BNP infusion and NEP inhibition in heart failure. Australian and New Zealand Journal of Medicine. 28, (pp. 119). [Abstract]

Rademaker, M. T., Charles, C. J., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (1998). Netriuretic peptides and endothelin un an ovine coronary ligation model of mild heart failure. Verbal presentation at the Endo '98, New Orleans.

Rademaker, M. T., Troughton, R. W., Charles, C. J., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (1998, November). Acute and chronic administration of Omapatrilat in an ovine model of mild and severe heart failure. Verbal presentation at the American Heart Association Meeting, Atlanta, USA.

Charles, C. J., Espiner, E. A., Rademaker, M. T., Nicholls, M. G., & Richards, A. M. (1998). Chronic infusions of brain natriuretic peptide in conscious sheep: Bioactivity at low physiological levels. Journal of Hypertension. 16(Suppl. 2), (pp. S143). [Abstract]

Rademaker, M. T., Charles, C. J., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (1998). Natriuretic peptides and endothelin on an ovine coronary artery ligation model of mild heart failure. 80th Annual Endocrine Society Meeting Programme. (A326). [Abstract]

Rademaker, M. T., Charles, C. J., Espiner, E. A., Nicholls, M. G., Richards, A. M., & Kosoglou, T. (1998). Combined neutral endopeptidase and angiotensin-converting enzyme inhibition in heart failure: role of natriuretic peptides and angiotensin II. Journal of Cardiovascular Pharmacology, 31(1), 116-125.

Espiner, E. A., Richards, A. M., & Nicholls, M. G. (1998). Physiology of natriuretic peptides. In E. R. Levin & J. Nadler (Eds.), Endocrinology of Cardiovascular Function. Kluwer Academic Publishers.

Florkowski, C. M., Stevens, I., Joyce, P. R., Espiner, E. A., & Donald, R. A. (1998). Growth hormone replacement does not improve psychological well-being in adult hypopituitarism: a randomized crossover trial. Psychoneuroendocrinology, 23(1), 57-63.

Lainchbury, J. G., Nicholls, M. G., Espiner, E. A., Ikram, H., Yandle, T. G., & Richards, A. M. (1998). Regional plasma levels of cardiac peptides and their response to acute neutral endopeptidase inhibition in man. Clinical Science, 95(5), 547-555.

Pemberton, C. J., Yandle, T. G., Rademaker, M. T., Charles, C. J., Aitken, G. D., & Espiner, E. A. (1998). Amino-terminal proBNP in ovine plasma: evidence for enhanced secretion in response to cardiac overload. American Journal of Physiology: Heart & Circulatory Physiology, 275(4Pt2), H1200-H1208.

Charles, C. J., Espiner, E. A., Nicholls, M. G., Rademaker, M. T., & Richards, A. M. (1998). Chronic infusions of brain natriuretic peptide in conscious sheep: bioactivity at low physiological levels. Clinical Science, 95(6), 701-708.

Richards, A. M., Nicholls, M. G., Yandle, T. G., Frampton, C., Espiner, E. A., Turner, J. G., … Lainchbury, J. G., Elliott, J. M., … Crozier, I. G., & Smyth, D. W. (1998). Plasma N-terminal pro-brain natriuretic peptide and adrenomedullin: New neurohormonal predictors of left ventricular function and prognosis after myocardial infarction. Circulation, 97(19), 1921-1929. doi: 10.1161/01.CIR.97.19.1921

Richards, A. M., Nicholls, M. G., Ikram, H., Espiner, E. A., Turner, J. G., Buttimore, R. C., Lainchbury, J. G., Elliott, J. M., Frampton, C. M., Crozier, I. G., & Smyth, D. W. (1998). Neuroendocrine prediction of left ventricular function and heart failure after acute myocardial infarction. Proceedings of the New Zealand Regional Meeting of the Cardiac Society of Australia and New Zealand. (1067), Sup 111, (pp. 40). New Zealand Medical Journal. [Abstract]

Lainchbury, J. G., Richards, A. M., Nicholls, M. G., Espiner, E. A., & Yandle, T. G. (1998). Infusion or co-infusion of brain natriuretic peptide and/or adrenomedullin in human heart failure. American College of Cardiology. 31(2 (Suppl. A), abstract no. 1070-38), (pp. 156a). Atlanta: American College of Cardiology. [Abstract]

Espiner, E. A., Rademaker, M. T., Charles, C. J., Kosoglou, T., Protter, A., Nicholls, M. G., & Richards, A. M. (1997). Inhibiting natriuretic peptide metabolism has beneficial renal hemodynamic effects, induces natriuresis and inhibits aldosterone in experimental heart failure. Verbal presentation at the 23rd Aldosterone Conference, Minneapolis.

Richards, A. M., Nicholls, M. G., Buttimore, R. C., Lainchbury, J. G., Frampton, C. M., Ikram, H., Espiner, E. A., Turner, J. G., Elliott, J. M., Crozier, I. G., & Smyth, D. W. (1997). Neuroendocrine prediction of left ventricular dysfunction and heart failure after myocardial infarction. Circulation, 96, (pp. I-389). [Abstract]

Lainchbury, J. G., Richards, A. M., Nicholls, M. G., Hunt, P. J., Ikram, H., Espiner, E. A., Yandle, T. G., & Begg, E. J. (1997). Effects of BNP infusion in heart failure. Clinical Science. S36, (pp. 1P). [Abstract]

Espiner, E. A., Rademaker, M. T., Charles, C. J., Kosoglou, T., Protter, A., Nicholls, M. G., & Richards, A. M. (1997). Inhibitory natriuretic peptide metabolism has beneficial renal hemodynamic effects, induces natriuresis and inhibits aldosterone in experimental heart failure. Verbal presentation at the 23rd Aldosterone Conference, Minneapolis.

Pemberton, C. J., Yandle, T. G., Rademaker, M. T., Charles, C. J., Aitken, G. D., & Espiner, E. A. (1997). The Amino Terminal Fragment of ProBNP Circulates In Ovine Plasma. Proceedings of the Endocrine Society of Australia. 40, (pp. 48). Melbourne, Australia: The Endocrine Society of Australia. [Abstract]

Lainchbury, J. G., Nicholls, M. G., Espiner, E. A., Yandle, T. G., & Richards, A. M. (1997). Cardiac hormones (Technical report, no.72). Commissioned by National Heart Foundation of New Zealand. Auckland: National Heart Foundation of New Zealand. 5p.

Pemberton, C. J., Yandle, T. G., Charles, C. J., Rademaker, M. T., Aitken, G. D., & Espiner, E. A. (1997). Ovine brain natriuretic peptide in cardiac tissues and plasma: effects of cardiac hypertrophy and heart failure on tissue concentration and molecular forms. Journal of Endocrinology, 155(3), 541-550.

Rademaker, M. T., Charles, C. J., Espiner, E. A., Frampton, C. M., Nicholls, M. G., & Richards, A. M. (1997). Comparative bioactivity of atrial and brain natriuretic peptides in an ovine model of heart failure. Clinical Science, 92(2), 159-165.

Florkowski, C. M., Hassan, E., Yandle, T. G., Livesey, J. L., Espiner, E. A., & Donald, R. A. (1997). Growth hormone replacement increases cardiac muscle mass and reduces brain natriuretic peptide response to exercise in adults with growth hormone deficiency. Endocrinology & Metabolism, 4(3), 167-171.

Florkowski, C. M., Walmsley, T. A., George, P. M., Livesey, J. L., Espiner, E. A., & Donald, R. A. (1997). The effect of growth hormone on biochemical parameters of bone turnover, and age-standardized IGF-I and IGFBP-3 in adult hypopituitarism: a randomized crossover trial. Endocrinology & Metabolism, 4(2), 129-134.

Espiner, E. A. (1997). Physiology of natriuretic peptides. In W. K. Samson & E. R. Levin (Eds.), Natriuretic Peptides in Health and Disease. (Contemporary Endocrinology, 5). (pp. 123-146). Totowa, N.J.: Humana Press.

Hunt, P. J., Richards, A. M., Nicholls, M. G., Yandle, T. G., Doughty, R. N., & Espiner, E. A. (1997). Immunoreactive amino-terminal pro-brain natriuretic peptide (NT-ProBNP): a new marker of cardiac impairment. Clinical Endocrinology, 47(3), 287-296.

Florkowski, C. M., Richards, A. M., Espiner, E. A., Yandle, T. G., Sybertz, E., & Frampton, C. M. (1997). Low-dose brain natriuretic peptide infusion in normal men and the influence of endopeptidase inhibition. Clinical Science, 92(3), 255-260.

Lainchbury, J. G., Richards, A. M., Nicholls, M. G., Hunt, P. J., Ikram, H., Espiner, E. A., Yandle, T. G., & Begg, E. (1997). The effects of pathophysiological increments in brain natriuretic peptide in left ventricular systolic dysfunction. Hypertension, 30, 398-404. doi: 10.1161/01.HYP.30.3.398

Fleischer, D., Espiner, E. A., Yandle, T. G., Livesey, J. L., Billings, J., Town, G. I., & Richards, A. M. (1997). Rapid assay of plasma brain natriuretic peptide in the assessment of acute dysphnoea. New Zealand Medical Journal, 110(1039), 71-74.

Lainchbury, J. G., Espiner, E. A., Frampton, C. M., Richards, A. M., Yandle, T. G., & Nicholls, M. G. (1997). Cardiac natriuretic peptides as predictors of mortality [Editorial]. Journal of Internal Medicine, 241(4), 257-259. doi: 10.1046/j.1365-2796.1997.295134000.x

Hunt, P. J., Espiner, E. A., Nicholls, M. G., Richards, A. M., & Yandle, T. G. (1997). The role of the circulation in processing pro-brain natriuretic peptide (Pro BNP) to amino-terminal BNP and BNP-32. Peptides, 18(10), 1475-1481.

Lainchbury, J. G., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (1997). Cardiac hormones: diagnostic and therapeutic potential. New Zealand Medical Journal, 110(1046), 219-221.

Rademaker, M. T., Charles, C. J., Kosoglou, T., Protter, A. A., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (1997). Clearance receptors and endopeptidase: equal role in natriuretic peptide metabolism in heart failure. American Journal of Physiology: Heart & Circulatory Physiology, 273(5 pt.2), H2372-H2379.

Wittert, G. A., Livesey, J. H., Espiner, E. A., & Donald, R. A. (1996). Adaption of the hypothalamo-pituitary adrenal axis to chronic exercise stress in humans. Medicine & Science in Sports & Exercise, 18(8), 1015-1019.

Nicholls, M. G., Richards, A. M., Espiner, E. A., & Yandle, T. G. (1996). Natriuretic peptides. Journal of the International Federation of Clinical Chemists, 8, 159-160.

Charles, C. J., Espiner, E. A., Richards, A. M., Yandle, T. G., Nicholls, M. G., Protter, A., & Kosoglou, T. (1996). Clearance receptors and endopeptidase 24.11: equal role in natriuretic peptide metabolism in conscious sheep. American Journal of Physiology: Heart & Circulatory Physiology, 271, R373-R380.

Pidgeon, G. B., Richards, A. M., Nicholls, M. G., Espiner, E. A., Yandle, T. G., & Frampton, C. M. (1996). Differing metabolism and bioactivity of atrial and brain natriuretic peptides in essential hypertension. Hypertension, 270, 906-913.

Florkowski, C. M., Collier, G. R., Zimmet, P. Z., Livesey, J. H., Espiner, E. A., & Donald, R. A. (1996). Low-dose growth hormone replacement lowers plasma leptin and fat stores without affecting body mass index in adults with growth hormone deficiency. Clinical Endocrinology, 45(6), 769-773.

Cameron, V. A., Aitken, G. D., Ellmers, L. J., Kennedy, M. A., & Espiner, E. A. (1996). The sites of gene expression of atrial, brain and C-type natriuretic peptides in mouse fetal development: Temporal changes in embryos and placenta. Endocrinology, 137(3), 817-824. doi: 10.1210/endo.137.3.8603590

Charles, C. J., Espiner, E. A., Yandle, T. G., Richards, A. M., & Nicholls, M. G. (1996). Comparative bioactivity of a trial, brain and C-type natriuretic peptides in conscious sheep. American Journal of Physiology: Regulatory, Integrative & Comparative Physiology, 270, R1324-R1331.

Rasat, R., Livesey, J. L., Espiner, E. A., Abbott, G. D., & Donald, R. A. (1996). IGF-1 and IGFBP-3 screening for disorders of growth hormone secretion. New Zealand Medical Journal, 109, 156-159.

Charles, C. J., Kaaja, R. J., Espiner, E. A., Nicholls, M. G., Pemberton, C. J., Richards, A. M., & Yandle, T. G. (1996). Natriuretic peptides in sheep with pressure overload left venticular hypertrophy. Clinical & Experimental Hypertension, 18(8), 1051-1071.

Rademaker, M. T., Charles, C. J., Espiner, E. A., Nicholls, M. G., Richards, A. M., & Kosoglou, T. (1996). Neural endopeptidase inhibition: augmented atrial and brain natriuretic peptide, haemodynamic and natriuretic responses in ovine heart failure. Clinical Science, 91, 283-291.

Hunt, P. J., Espiner, E. A., Nicholls, M. G., Richards, A. M., & Yandle, T. G. (1996). Differing biological effects of equimolar atrial and brain natriuretic peptide infusions in normal man. Journal of Clinical Endocrinology & Metabolism, 81(11), 3871-3876.

Rademaker, M. T., Charles, C. J., Espiner, E. A., Frampton, C. M., Nicholls, M. G., Richards, A. M., & Yandle, T. G. (1996). Natriuretic peptide responses to acute and chronic ventricular pacing in sheep: evidence for differential secretion of ANP and BNP. American Journal of Physiology: Heart & Circulatory Physiology, 270, H594-H600.

Rademaker, M. T., Fitzpatrick, M. A., Charles, C. J., Richards, A. M., Nicholls, M. G., Espiner, E. A., & Sybertz, E. (1996). Comparison of chronic neutral endopeptidase inhibition and furosemide in an ovine model of heart failure. Journal of Cardiovascular Pharmacology, 27(3), 439-446.

Hunt, P. J., Espiner, E. A., Richards, A. M., Yandle, T. G., Frampton, C. M., & Nicholls, M. G. (1995). Interactions of atrial and brain natriuretic peptides at pathophysiological levels in normal men. American Journal of Physiology: Regulatory, Integrative & Comparative Physiology, 269, 1397-1403.

Espiner, E. A., Richards, A. M., Yandle, T. G., & Nicholls, M. G. (1995). Natriuretic hormones. Endocrinology & Metabolism Clinics of North America, 24, 481-509.

Rademaker, M. T., Fitzpatrick, M. A., Charles, C. J., Frampton, C. M., Richards, A. M., Nicholls, M. G., & Espiner, E. A. (1995). Central angiotensin II AT1-receptor antagonism in normal and heart failed sheep. American Journal of Physiology: Heart & Circulatory Physiology, 269, H425-H432.

Voss, D. M., Lynn, K. L., Buttimore, A. L., & Espiner, E. A. (1995). Changes in blood pressure and vasoactive hormones during volume expansion in stable patients on chronic haemodialysis. Nephrology, 1, 577-581.

Hunt, P. J., Yandle, T. G., Richards, A. M., Espiner, E. A., & Nicholls, M. G. (1995). The amino-terminal portion of pro-brain natriuretic peptide (Pro-BNP) circulates in human plasma. Biochemical & Biophysical Research Communications, 214, 1175-1183.

Rasat, R., Espiner, E. A., & Abbott, G. D. (1995). Growth patterns and outcomes in congenital adrenal hyperplasia: effect of chronic treatment regimens. New Zealand Medical Journal, 108, 311-314.

Davis, M., Espiner, E., Richards, G., Billings, J., Town, I., Neill, A., Drennan, C., Richards, M., Turner, J., & Yandle, T. (1994). Plasma brain natriuretic peptide in assessment of acute dyspnoea. Lancet, 343(8895), 440-444. doi: 10.1016/S0140-6736(94)92690-5

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