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Steven Cui Research Fellow

BE (China) ME (Adelaide) PhD (Adelaide)

Email steven.cui@otago.ac.nz

Background and research interests

As a professional biochemical engineer, Dr Cui joined the CReaTE group as a Postdoctoral Fellow after completing his PhD from the University of Adelaide in 2017, and was then promoted to Research Fellow in 2019.

Dr Cui’s expertise lies in the interface of stem cells, biomaterials, and biofabrication with a special interest in cartilage and bone regeneration, as well as cardiovascular disease diagnosis and treatment. He has experience in polymer synthesis, tissue culture, anticancer drug screening, drug and gene delivery systems, and stem cell therapy. Currently he is leading a number of pre-clinical trials in the tissue engineering space.

Dr Cui has been awarded a number of research grants helping his research in the use of stem cells in regenerative medicine, such as the Explorer Grant from the Health Research Council of New Zealand supporting his research into the use of synthetic stem cells in the treatment of myocardial infarction (also known as heart attack), and a project grant from the New Zealand Equine Trust supporting the conduct of large-animal pre-clinical trials assessing the therapeutic effect of bioassembled constructs in cartilage repair.

Currently he holds a prestigious Health Science Career Development Postdoctoral Fellowship which supports his investigation into a “bottom-up” biofabrication strategy for cartilage regeneration. He is also involved in a number of national and international collaborations (Australia, China, USA, UK). His research projects include:

  • Exosome for cartilage and cardiovascular disease diagnosis and treatment
  • "Bottom-up" biofabrication strategy for osteochondral regeneration
  • Smart hydrogel to deliver growth factors for cardiac repair
  • Silk hydrogel for tissue engineering and regenerative medicine

Appointments

  • Research Fellow, University of Otago, Department of Orthopaedic Surgery and Musculoskeletal Medicine, CReaTE research group, 2019
  • Postdoctoral Fellow, University of Otago, Department  of Orthopaedic Surgery and Musculoskeletal Medicine, CReaTE research group, 2017
  • Visiting researcher, South Australian Health and Medical Research Institute, 2016
  • Visiting scholar, North Carolina State University, 2015-2016
  • Research Assistant, University of Adelaide, 2012
  • Project Engineer, China National Petroleum Corporation, 2009

Awards

  • The University of Otago Health Sciences Division, Career Development Postdoctoral Fellowship, 2019-2021
  • The University of Adelaide Divisional Scholarship, 2013-2017

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Publications

Li, J., Cui, X., Hooper, G. J., Lim, K. S., & Woodfield, T. B. F. (2020). Rational design, bio-functionalization and biological performance of hybrid additive manufactured titanium implants for orthopaedic applications: A review. Journal of the Mechanical Behavior of Biomedical Materials, 105, 103671. doi: 10.1016/j.jmbbm.2020.103671

Lim, K. S., Galarraga, J. H., Cui, X., Lindberg, G. C. J., Burdick, J. A., & Woodfield, T. B. F. (2020). Fundamentals and applications of photo-cross-linking in bioprinting. Chemical Reviews. Advance online publication. doi: 10.1021/acs.chemrev.9b00812

Zhang, J., Cui, X., Guo, J., Cao, C., Zhang, Z., Wang, B., … Lim, K., Woodfield, T., … Zhang, J. (2020). Small but significant: Insights and new perspectives of exosomes in cardiovascular disease. Journal of Cellular & Molecular Medicine, 24, 8291-9303. doi: 10.1111/jcmm.15492

Cui, X., Soliman, B. G., Alcala-Orozco, C. R., Li, J., Vis, M. A. M., Santos, M., … Woodfield, T. B. F., … Lim, K. S. (2020). Rapid photocrosslinking of silk hydrogels with high cell density and enhanced shape fidelity. Advanced Healthcare Materials, 9, 1901667. doi: 10.1002/adhm.201901667

Cui, X., Li, J., Hartanto, Y., Durham, M., Tang, J., Zhang, H., Hooper, G., Lim, K., & Woodfield, T. (2020). Advances in extrusion 3D bioprinting: A focus on multicomponent hydrogel-based bioinks. Advanced Healthcare Materials, 9, 1901648. doi: 10.1002/adhm.201901648

Chapter in Book - Research

Atienza Roca, P., Cui, X., Hooper, G. J., Woodfield, T. B. F., Lim, K. S., & Khang, G. (2018). Growth factor delivery systems for tissue engineering and regenerative medicine. In H. J. Chun, C. H. Park & I. K. Kwon (Eds.), Advances in experimental medicine and biology: (Vol. 1078) Cutting-edge enabling technologies for regenerative medicine. (pp. 245-269). Singapore: Springer. doi: 10.1007/978-981-13-0950-2_13

Hartanto, Y., Jin, B., Cui, X., & Dai, S. (2018). Emerging applications of stimuli-responsive microgels in water treatment process. In W.-F. Lai (Ed.), Microgels: Synthesis, properties and applications. (pp. 229-255). New York, NY: Nova Science.

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Journal - Research Article

Li, J., Cui, X., Hooper, G. J., Lim, K. S., & Woodfield, T. B. F. (2020). Rational design, bio-functionalization and biological performance of hybrid additive manufactured titanium implants for orthopaedic applications: A review. Journal of the Mechanical Behavior of Biomedical Materials, 105, 103671. doi: 10.1016/j.jmbbm.2020.103671

Cui, X., Li, J., Hartanto, Y., Durham, M., Tang, J., Zhang, H., Hooper, G., Lim, K., & Woodfield, T. (2020). Advances in extrusion 3D bioprinting: A focus on multicomponent hydrogel-based bioinks. Advanced Healthcare Materials, 9, 1901648. doi: 10.1002/adhm.201901648

Cui, X., Soliman, B. G., Alcala-Orozco, C. R., Li, J., Vis, M. A. M., Santos, M., … Woodfield, T. B. F., … Lim, K. S. (2020). Rapid photocrosslinking of silk hydrogels with high cell density and enhanced shape fidelity. Advanced Healthcare Materials, 9, 1901667. doi: 10.1002/adhm.201901667

Zhang, J., Cui, X., Guo, J., Cao, C., Zhang, Z., Wang, B., … Lim, K., Woodfield, T., … Zhang, J. (2020). Small but significant: Insights and new perspectives of exosomes in cardiovascular disease. Journal of Cellular & Molecular Medicine, 24, 8291-9303. doi: 10.1111/jcmm.15492

Lim, K. S., Galarraga, J. H., Cui, X., Lindberg, G. C. J., Burdick, J. A., & Woodfield, T. B. F. (2020). Fundamentals and applications of photo-cross-linking in bioprinting. Chemical Reviews. Advance online publication. doi: 10.1021/acs.chemrev.9b00812

Atienza-Roca, P., Kieser, D., Cui, X., Bathish, B., Ramaswamy, Y., Hooper, G. J., Clarkson, A. N., … Wise, L. M., Woodfield, T. B. F., & Lim, K. S. (2020). Visible light mediated PVA-tyramine hydrogels for covalent incorporation and tailorable release of functional growth factors. Biomaterials Science, 8(18), 5005-5019. doi: 10.1039/D0BM00603C

Alcala-Orozco, C. R., Mutreja, I., Cui, X., Kumar, D., Hooper, G. J., Lim, K. S., & Woodfield, T. B. F. (2020). Design and characterisation of multi-functional strontium-gelatin nanocomposite bioinks with improved print fidelity and osteogenic capacity. Bioprinting, 18, e00073. doi: 10.1016/j.bprint.2019.e00073

Zhang, J., Tang, J., Cui, X., Wang, B., Bu, M., Bai, Y., … Zhang, J. (2019). Indirect comparison of novel oral anticoagulants among Asians with non-valvular atrial fibrillation in the real world setting: A network meta-analysis. BMC Cardiovascular Disorders, 19(1), 182. doi: 10.1186/s12872-019-1165-5

Hartanto, Y., Zargar, M., Cui, X., Jin, B., & Dai, S. (2019). Non-ionic copolymer microgels as high-performance draw materials for forward osmosis desalination. Journal of Membrane Science, 572, 480-488. doi: 10.1016/j.memsci.2018.11.042

Guo, J., Tang, J., Cui, X., Zhang, L., Zhang, H., Cao, C., … Zhang, J. (2018). Elevated red cell distribution width is associated with poor clinical outcomes in non-ischemic dilated cardiomyopathy. International Journal of Clinical & Experimental Medicine, 11(8), 8102-8109.

Asaduzzman, M., Cui, X., Zhang, H., & Young, F. (2018). Three dimensional in vitro culture of murine secondary follicles in a defined synthetic matrix. Journal of Biomaterials & Nanobiotechnology, 9(3), 244-262. doi: 10.4236/jbnb.2018.93014

Tang, J.-N., Cores, J., Huang, K., Cui, X.-L., Luo, L., Zhang, J.-Y., … Cheng, K. (2018). Concise review: Is cardiac cell therapy dead? Embarrassing trial outcomes and new directions for the future. Stem Cells Translational Medicine, 7(4), 354-359. doi: 10.1002/sctm.17-0196

Cui, X., Hartanto, Y., Wu, C., Bi, J., Dai, S., & Zhang, H. (2018). Tuning microenvironment for multicellular spheroid formation in thermo-responsive anionic microgel scaffolds. Journal of Biomedical Materials Research Part A, 106A, 2899-2909. doi: 10.1002/jbma.36479

Cui, X., Tang, J., Hartanto, Y., Zhang, J., Bi, J., Dai, S., … Zhang, H. (2018). NIPAM-based microgel microenvironment regulates the therapeutic function of cardiac stromal cells. ACS Applied Materials & Interfaces, 10, 37783-37796. doi: 10.1021/acsami.8b09757

Tang, J., Cui, X., Caranasos, T. G., Hensley, M. T., Vandergriff, A. C., Hartanto, Y., … Cheng, K. (2017). Heart repair using nanogel-encapsulated human cardiac stem cells in mice and pigs with myocardial infarction. ACS Nano, 11(10), 9738-9749. doi: 10.1021/acsnano.7b01008

Cui, X., Hartanto, Y., & Zhang, H. (2017). Advances in multicellular spheroids formation. Journal of the Royal Society Interface, 14(127), 20160877. doi: 10.1098/rsif.2016.0877

Hartanto, Y., Zargar, M., Cui, X., Shen, Y., Jin, B., & Dai, S. (2016). Thermoresponsive cationic copolymer microgels as high performance draw agents in forward osmosis desalination. Journal of Membrane Science, 518, 273-281. doi: 10.1016/j.memsci.2016.07.018

Liu, Y., Wang, Z.-J., Li, L., Cui, X., Chu, J., Zhang, S.-L., & Zhuang, Y.-P. (2016). On-line monitoring of the aggregate size distribution of Carthamus tinctorius L. cells with multi-frequency capacitance measurements. RSC Advances, 6(92), 89764-89769. doi: 10.1039/c6ra13527g

Cui, X., Liu, Y., Hartanto, Y., Bi, J., Dai, S., & Zhang, H. (2016). Multicellular spheroids formation and recovery in microfluidics-generated thermoresponsive microgel droplets. Colloid & Interface Science Communications, 14, 4-7. doi: 10.1016/j.colcom.2016.09.001

Cui, X., Dini, S., Dai, S., Bi, J., Binder, B. J., Green, J. E. F., & Zhang, H. (2016). A mechanistic study on tumour spheroid formation in thermosensitive hydrogels: Experiments and mathematical modelling. RSC Advances, 6(77), 73282-73291. doi: 10.1039/C6RA11699J

Yan, L., Cui, X., Harada, T., Lincoln, S. F., Dai, S., & Kee, T. W. (2016). Generation of fluorescent and stable conjugated polymer nanoparticles with hydrophobically modified poly(acrylate)s. Macromolecules, 49(22), 8530-8539. doi: 10.1021/acs.macromol.6b02002

Zhang, H., Cui, X., Bi, J., Dai, S., & Ye, H. (2015). Single-cell analysis for bioprocessing. Engineering in Life Sciences, 15(6), 582-592. doi: 10.1002/elsc.201400155

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Conference Contribution - Published proceedings: Abstract

Cui, S., Li, J., Alcala-Orozco, C., Woodfield, T., Rnjak-Kovacina, J., & Lim, K. (2019). Rapid visible light crosslinking of silk hydrogels for cartilage tissue engineering. Proceedings of the European Society for Biomaterials (ESB) 30th Annual Conference and the German Society for Biomaterials (DGBM) 26th Annual Conference. X-OS19-04. Retrieved from https://www.esb2019.org/

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Conference Contribution - Poster Presentation (not in published proceedings)

Alcala-Orozco, C. R., Mutreja, I., Cui, X., Hooper, G. J., Lim, K. S., & Woodfield, T. B. F. (2019, April). Strontium-based nanocomposite bioink for 3D bioprinting of high shape-fidelity osteoconductive scaffolds. Poster session presented at the Australasian Society for Biomaterials and Tissue Engineering (ASBTE) Early Career Researcher Workshop, Sydney, Australia.

Tang, J., Cui, X., Hensley, M., Vandergriff, A., Cores, J., Allen, T., … Cheng, K. (2016, October). A regenerative bio-minipump created by cardiac stem cells encapsulated in thermo-sensitive microgel. Poster session presented at the Biomedical Engineering Society Annual Meeting, Minneapolis, USA.

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Conference Contribution - Verbal presentation and other Conference outputs

Aldrich, E. D., Cui, S., Lim, K. S., & Woodfield, T. (2019, August-September). The horse as a model and translational stepping stone in orthopaedic research. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Woodfield, T. B. F., Lim, K. S., Lindberg, G. C. J., Cui, S., Alcala-Orozco, C., & Hooper, G. J. (2019, August-September). Biofabrication of the musculoskeletal tissue niche: Tissue spheroid and bioink platiforms. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Cui, S. (2018, April). NIPAM-based microgel microenvironment regulates cardiac stem cells for myocardial infarction treatment. Verbal presentation at the University of Otago Centre for Bioengineering & Nanomedicine Symposium: Biomaterials and Regenerative Medicine, Dunedin, New Zealand.

Cui, X., Tang, J., Bi, J., Dai, S., Cheng, K., & Zhang, H. (2018, June). The impact of hydrogel microenvironment on multicellular spheroids formation and function. Verbal presentation at the Biotechnology Bring Bright Future: The Post-Doctoral Academic Symposium, Shanghai, China.

Cui, X., Durham, M., Li, J., Aldrich, E., Lim, K., & Woodfield, T. (2018, December). Improving chondrogenesis of equine umbilical cord blood-mesenchymal stem cell in three-dimensional hydrogel by synergistic control of chemical and mechanical cues. Verbal presentation at the 41st Scientific Meeting of the Matrix Biology Society of Australia and New Zealand, Auckland, New Zealand.

Cui, S. (2017, November). Impact of the scaffold microenvironment on multicellular spheroid formation and function. Verbal presentation at the Workshop on Biomaterials for Tissue Engineering and Regenerative Medicines, Adelaide, Australia.

Asaduzzaman, M., Kennedy, D., Cui, X., Zhang, H., & Young, F. (2016, September). Culturing mouse ovarian follicles in 3D culture matrix. Verbal presentation at the Fertility Society of Australia (FSA) Annual Conference, Perth, Australia.

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Awarded Doctoral Degree

Cui, X. (2017). Thermoresponsive microgels for multicellular spheroids formation (PhD). University of Adelaide, Adelaide, Australia.

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