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Research focus

Gretel is developing 3D hydrogel matrices with encapsulated adipocytes for fat grafting and in vitro models of breast cancer.

She is supervised by Professor Tim Woodfield and Dr Khoon Lim.

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Soliman, B. G., Major, G. S., Atienza-Roca, P., Murphy, C. A., Longoni, A., Alcala-Orozco, C. R., … Woodfield, T. B. F., & Lim, K. S. (2021). Development and characterization of gelatin-norbornene bioink to understand the interplay between physical architecture and micro-capillary formation in biofabricated vascularized constructs. Advanced Healthcare Materials, e2101873. Advance online publication. doi: 10.1002/adhm.202101873

Major, G. S., Simcock, J. W., Woodfield, T. B. F., & Lim, K. S. (2021). Overcoming functional challenges in autologous and engineered fat grafting trends. Trends in Biotechnology. Advance online publication. doi: 10.1016/j.tibtech.2021.04.006

Perry, J., Ashford, B., Thind, A. S., Gauthier, M.-E., Minaei, E., Major, G., … Ranson, M. (2020). Comprehensive mutational and phenotypic characterization of new metastatic cutaneous squamous cell carcinoma cell lines reveal novel drug susceptibilities. International Journal of Molecular Sciences, 21(24), 9536. doi: 10.3390/ijms21249536

Chitty, J. L., Skhinas, J. N., Filipe, E. C., Wang, S., Rodriquez Cupello, C., Grant, R. D., … Major, G., … Cox, T. R. (2020). The Mini-Organo: A rapid high-throughput 3D coculture organotypic assay for oncology screening and drug development. Cancer Reports, 3(1), e1209. doi: 10.1002/cnr2.1209

Elgundi, Z., Papanicolaou, M., Major, G., Cox, T. R., Melrose, J., Whitelock, J. M., & Farrugia, B. L. (2020). Cancer metastasis: The role of the extracellular matrix and the heparan sulfate proteoglycan perlecan. Frontiers in Oncology, 9, 1482. doi: 10.3389/fonc.2019.01482