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Emeritus Professor Brian A. Darlow

Brian DarlowMA BChir MA MD(Camb) FRCP FRACP FRCPCH

Email brian.darlow@otago.ac.nz

Tel +64 3 372 6735

Brian Darlow trained at Cambridge University, elsewhere in the United Kingdom and New Zealand, with a spell in Papua New Guinea.

He returned to the department as Senior Lecturer in 1982 and was appointed to the Chair of Paediatrics in 2001.  From 2007 until 2018 Brian held the Cure Kids Chair of Paediatric Research at the University of Otago, Christchurch.

Through most of his career he has worked as a clinical neonatologist and his research interests include free radical disease in the newborn, the epidemiology and outcome of complications of prematurity, and neonatal networking.

Interests outside of medicine include ornithology and tramping.

Read about the NZ Very Low Birthweight study

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Publications

Pascoe, M. J., Melzer, T. R., Horwood, L. J., Woodward, L. J., & Darlow, B. A. (2019). Altered grey matter volume, perfusion and white matter integrity in very low birthweight adults. NeuroImage: Clinical. Advance online publication. doi: 10.1016/j.nicl.2019.101780

Darlow, B. A., & Husain, S. (2019). Primary prevention of ROP and the oxygen saturation targeting trials. Seminars in Perinatology. Advance online publication. doi: 10.1053/j.semperi.2019.05.004

Darlow, B. A., Martin, J., & Horwood, L. J. (2019). Unrecognised and unmet physical health problems in a national cohort of very low birthweight young adults and controls. Journal of Primary Health Care, 11(1), 32-38. doi: 10.1071/HC18044

Darlow, B. A., & Gilbert, C. (2019). Retinopathy of prematurity : A world update. Seminars in Perinatology. Advance online publication. doi: 10.1053/j.semperi.2019.05.001

Darlow, B. A., Martin, J., & Horwood, L. J. (2018). Metabolic syndrome in very low birth weight young adults and controls: The New Zealand 1986 VLBW Study. Journal of Pediatrics. Advance online publication. doi: 10.1016/j.jpeds.2018.10.060

Chapter in Book - Research

Darlow, B. (2012). The newborn infant: Stabilization and examination. In M. South & D. Isaacs (Eds.), Practical paediatrics. (7th ed.) (pp. 328-340). Edinburgh, UK: Churchill Livingstone.

Begg, E. J., Atkinson, H. C., & Darlow, B. A. (1997). Guide to drug usage in lactation. In T. M. Speight & N. H. G. Holford (Eds.), Avery's Drug Treatment: a Guide to the Properties, Choice, Therapeutic Use and Economic Value of Drugs in Disease Management, 4th edition. (pp. 1701-1723). Auckland: Adis Press.

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Chapter in Book - Other

Darlow, B. (2013). Neonatal Health. In P. Joyce, G. Nicholls, K. Thomas & T. Wilkinson (Eds.), The Christchurch experience: 40 years of research and teaching. (pp. 88-95). Christchurch, New Zealand: University of Otago.

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Journal - Research Article

Pascoe, M. J., Melzer, T. R., Horwood, L. J., Woodward, L. J., & Darlow, B. A. (2019). Altered grey matter volume, perfusion and white matter integrity in very low birthweight adults. NeuroImage: Clinical. Advance online publication. doi: 10.1016/j.nicl.2019.101780

Darlow, B. A., Martin, J., & Horwood, L. J. (2019). Unrecognised and unmet physical health problems in a national cohort of very low birthweight young adults and controls. Journal of Primary Health Care, 11(1), 32-38. doi: 10.1071/HC18044

Darlow, B. A., & Husain, S. (2019). Primary prevention of ROP and the oxygen saturation targeting trials. Seminars in Perinatology. Advance online publication. doi: 10.1053/j.semperi.2019.05.004

Darlow, B. A., Martin, J., & Horwood, L. J. (2018). Metabolic syndrome in very low birth weight young adults and controls: The New Zealand 1986 VLBW Study. Journal of Pediatrics. Advance online publication. doi: 10.1016/j.jpeds.2018.10.060

Prickett, T. C. R., Darlow, B. A., Troughton, R. W., Cameron, V. A., Elliott, J. M., Martin, J., Horwood, L. J., & Espiner, E. A. (2018). New insights into cardiac and vascular natriuretic peptides: Findings from young adults born with very low birth weight. Clinical Chemistry, 64(2), 363-373. doi: 10.1373/clinchem.2017.280354

Beltempo, M., Isayama, T., Vento, M., Lui, K., Kusuda, S., Lehtonen, L., … Darlow, B. A., … on behalf of the International Network for Evaluating Outcomes (iNeo) of Neonates. (2018). Respiratory management of extremely preterm infants: An international survey. Neonatology, 114(1), 28-36. doi: 10.1159/000487987

Shah, P. S., Kusuda, S., Håkansson, S., Reichman, B., Lui, K., Lehtonen, L., … Darlow, B. A., … on behalf of the International Network for Evaluating Outcomes (iNeo) in Neonates Investigators. (2018). Neonatal outcomes of very preterm or very low birth weight triplets. Pediatrics, 142(6), e20181938. doi: 10.1542/peds.2018-1938

Fleck, B. W., Williams, C., Juszczak, E., Cocker, K., Stenson, B. J., Darlow, B. A., … for the BOOST II Retinal Image Digital Analysis (RIDA) Group. (2018). An international comparison of retinopathy of prematurity grading performance within the Benefits of Oxygen Saturation Targeting II trials. Eye, 32, 74-80. doi: 10.1038/eye.2017.150

Darlow, B. A., Vento, M., Beltempo, M., Lehtonen, L., Håkansson, S., Reichman, B., … on behalf of the International Network for Evaluating Outcomes (iNeo) of Neonates. (2018). Variations in oxygen saturation targeting, and retinopathy of prematurity screening and treatment criteria in neonatal intensive care units: An international survey. Neonatology, 114(4), 323-331. doi: 10.1159/000490372

Porter, J. A., MacKenzie, K. E., Darlow, B. A., Butler, R., & Day, A. S. (2018). Gastric emptying in children with type 1 diabetes mellitus: A pilot study. Journal of Paediatrics & Child Health. Advance online publication. doi: 10.1111/jpc.14215

Darlow, B. A., Elder, M. J., Kimber, B., Martin, J., & Horwood, L. J. (2018). Vision in former very low birthweight young adults with and without retinopathy of prematurity compared with term born controls: The NZ 1986 VLBW follow-up study. British Journal of Ophthalmology, 102, 1041-1046. doi: 10.1136/bjophthalmol-2017-311345

Chan-Ling, T., Gole, G. A., Quinn, G. E., Adamson, S. J., & Darlow, B. A. (2018). Pathophysiology, screening and treatment of ROP: A multi-disciplinary perspective. Progress in Retinal & Eye Research, 62, 77-119. doi: 10.1016/j.preteyeres.2017.09.002

Askie, L. M., Darlow, B. A., Finer, N., Schmidt, B., Stenson, B., Tarnow-Mordi, W., … for the Neonatal Oxygenation Prospective Meta-analysis (NeOProM) Collaboration. (2018). Association between oxygen saturation targeting and death or disability in extremely preterm infants in the Neonatal Oxygenation Prospective Meta-analysis Collaboration. JAMA, 319(21), 2190-2201. doi: 10.1001/jama.2018.5725

Smith, L. E. H., Hellström, A., Stahl, A., Fielder, A., Chambers, W., Moseley, J., … Darlow, B. A., … for the Retinopathy of Prematurity Workgroup of the International Neonatal Consortium. (2018). Development of a retinopathy of prematurity activity scale and clinical outcome measures for use in clinical trials [Special communication]. JAMA Ophthalmology. Advance online publication. doi: 10.1001/jamaophthalmol.2018.5984

Koller-Smith, L. I. M., Shah, P. S., Ye, X. Y., Sjörs, G., Wang, Y. A., Chow, S. S. W., Darlow, B. A., … on behalf of the Australian and New Zealand Neonatal Network, Canadian Neonatal Network, Swedish Neonatal Quality Register, and also Broadbent, R. (2017). Comparing very low birth weight versus very low gestation cohort methods for outcome analysis of high risk preterm infants. BMC Pediatrics, 17, 166. doi: 10.1186/s12887-017-0921-x

Darlow, B. A., Lui, K., Kusuda, S., Reichman, B., Håkansson, S., Bassler, D., … on behalf of the International Network for Evaluating Outcomes of Neonates (iNeo). (2017). International variations and trends in the treatment for retinopathy of prematurity. British Journal of Ophthalmology, 101(10), 1399-1404. doi: 10.1136/bjophthalmol-2016-310041

Askie, L. M., Darlow, B. A., Davis, P. G., Finer, N., Stenson, B., Vento, M., & Whyte, R. (2017). Effects of targeting lower versus higher arterial oxygen saturations on death or disability in preterm infants (Review). Cochrane Database of Systematic Reviews, 4, CD011190. doi: 10.1002/14651858.CD011190.pub2

Kelly, L. E., Shah, P. S., Håkansson, S., Kusuda, S., Adams, M., Lee, S. K., … Darlow, B. A., … for the investigators of the International Network for Evaluating Outcomes (iNeo) of Neonates. (2017). Perinatal health services organization for preterm births: A multinational comparison. Journal of Perinatology, 37, 762-768. doi: 10.1038/jp.2017.45

Helenius, K., Sjörs, G., Shah, P. S., Modi, N., Reichman, B., Morisaki, N., … Darlow, B. A., … on behalf of the International Network for Evaluating Outcomes (iNeo) of Neonates. (2017). Survival in Very Preterm Infants: An International Comparison of 10 National Neonatal Networks. Pediatrics, 140(6), e20171264. doi: 10.1542/peds.2017-1264

Gilbert, C., Wormald, R., Fielder, A., Deorari, A., Zepeda-Romero, L. C., Quinn, G., … Darlow, B. (2016). Potential for a paradigm change in the detection of retinopathy of prematurity requiring treatment. Archives of Disease in Childhood: Fetal & Neonatal Edition, 101(1), F6-F9. doi: 10.1136/archdischild-2015-308704

Shah, P. S., Lui, K., Sjörs, G., Mirea, L., Reichman, B., Adams, M., … Darlow, B. A., … for the for the International Network for Evaluating Outcomes (iNeo) of Neonates including, including Broadbent, R. (2016). Neonatal outcomes of very low birth weight and very preterm neonates: An international comparison. Journal of Pediatrics, 177, 144-152. doi: 10.1016/j.jpeds.2016.04.083

Martin, L. J., Sjörs, G., Reichman, B., Darlow, B. A., Morisaki, N., Modi, N., … on behalf of the International Network for Evaluating Outcomes (iNeo) of Neonates Investigators. (2016). Country-specific vs. common birthweight-for-gestational age references to identify small for gestational age infants born at 24–28 weeks: An international study. Paediatric & Perinatal Epidemiology, 30(5), 450-461. doi: 10.1111/ppe.12298

Harris, S. L., Austin, N. C., Battin, M., Broadbent, R., Horwood, J., Keenan, R., … Graham, P., Woodward, L. J., & Darlow, B. A. (2016). In-hospital morbidity and brain metrics of preterm neonates born 1998–2009. New Zealand Medical Journal, 129(1440), 94-107. Retrieved from https://www.nzma.org.nz/journal

Boost-II Australia and United Kingdom Collaborative Groups, including Darlow, B. A. (2016). Outcomes of two trials of oxygen-saturation targets in preterm infants. New England Journal of Medicine, 374(8), 749-760. doi: 10.1056/NEJMoa1514212

Chawla, D., & Darlow, B. A. (2016). Anti-vascular endothelial growth factor preparations in the treatment of retinopathy of prematurity: Balancing risks and benefits. Indian Pediatrics, 53(Suppl. 2), S129-S136.

Gemmell, L., Martin, L., Murphy, K. E., Modi, N., Håkansson, S., Reichman, B., … Darlow, B. A., … for the International Network for Evaluating Outcomes (iNEO) of Neonates Investigators. (2016). Hypertensive disorders of pregnancy and outcomes of preterm infants of 24 to 28 weeks' gestation. Journal of Perinatology, 36, 1067-1072. doi: 10.1038/jp.2016.133

Darlow, B. A., Voss, L., Lennon, D. R., & Grimwood, K. (2016). Early-onset neonatal group B streptococcus sepsis following national risk-based prevention guidelines. Australian & New Zealand Journal of Obstetrics & Gynaecology, 56, 69-74. doi: 10.1111/ajo.12378

Darlow, B. A., Graham, P. J., & Rojas-Reyes, M. X. (2016). Vitamin A supplementation to prevent mortality and short- and long-term morbidity in very low birth weight infants (Review). Cochrane Database of Systematic Reviews, 8, CD000501. doi: 10.1002/14651858.CD000501.pub4

Hossain, S., Shah, P. S., Ye, X. Y., Darlow, B. A., Lee, S. K., Lui, K., on behalf of the Canadian Neonatal Network, and Australian and New Zealand Neonatal Network. (2016). Outborns or inborns: Where are the differences? A comparison study of very preterm neonatal intensive care unit infants cared for in Australia and New Zealand and in Canada. Neonatology, 109(1), 76-84. doi: 10.1159/000441272

Zahari, M., Lee, D. S., & Darlow, B. A. (2016). Algorithms that eliminate the effects of calibration artefact and trial-imposed offsets of Masimo oximeter in BOOST-NZ trial. Journal of Clinical Monitoring & Computing, 30, 669-678. doi: 10.1007/s10877-015-9752-1

Darlow, B. A., & Morley, C. J. (2015). Oxygen saturation targeting and bronchopulmonary dysplasia. Clinics in Perinatology, 42(4), 807-823. doi: 10.1016/j.clp.2015.08.008

Hossain, S., Shah, P. S., Ye, X. J., Darlow, B. A., Lee, S. K., Lui, K., on behalf of the Canadian Neonatal Network, and Australian and New Zealand Neonatal Network. (2015). Outcome comparison of very preterm infants cared for in the neonatal intensive care units in Australia and New Zealand and in Canada. Journal of Paediatrics & Child Health, 51, 881-888. doi: 10.1111/jpc.12863

Darlow, B. A. (2015). Retinopathy of prematurity: New developments bring concern and hope. Journal of Paediatrics & Child Health, 51(8), 765-770. doi: 10.1111/jpc.12860

Tan, Z., Chong, C., Darlow, B., & Dai, S. (2015). Visual impairment due to retinopathy of prematurity (ROP) in New Zealand: A 22-year review. British Journal of Ophthalmology, 99, 801-806. doi: 10.1136/bjophthalmol-2014-305913

Guillén, U., Weiss, E. M., Munson, D., Maton, P., Jefferies, A., Norman, M., … Darlow, B., & Kirpalani, H. (2015). Guidelines for the management of extremely premature deliveries: A systematic review. Pediatrics, 136(2), 343-350. doi: 10.1542/peds.2015-0542

Darlow, B. A., Marschner, S. L., Donoghoe, M., Battin, M. R., Broadbent, R. S., Elder, M. J., Hewson, M. P., … Graham, P., McNeill, N. J., … on behalf of the Benefits Of Oxygen Saturation Targeting-New Zealand (BOOST-NZ) Collaborative Group. (2014). Randomized controlled trial of oxygen saturation targets in very preterm infants: Two year outcomes. Journal of Pediatrics, 165(1), 30-35. doi: 10.1016/j.jpeds.2014.01.017

Reid, R. A., Prickett, T. C. R., Pullar, B. E., Darlow, B. A., Gullam, J. E., & Espiner, E. A. (2014). C-type natriuretic peptide in complicated pregnancy: Increased secretion precedes adverse events. Journal of Clinical Endocrinology & Metabolism, 99(4), 1470-1478. doi: 10.1210/jc.2013-3758

Porter, J. A., MacKenzie, K., Darlow, B., & Day, A. S. (2014). Looking for coeliac disease in children with type 1 diabetes mellitus. Journal of Paediatrics & Child Health, 50(10), 811-816. doi: 10.1111/jpc.12643

Gilbert, C., Darlow, B., Zin, A., Sivasubramaniam, S., Shah, S., Gianini, N., … Lopes Moreira, M. E. (2014). Educating neonatal nurses in Brazil: A before-and-after study with interrupted time series analysis. Neonatology, 106(3), 201-208. doi: 10.1159/000362532

Mulder, R. T., Carter, J. D., Frampton, C. M. A., & Darlow, B. A. (2014). Good two-year outcome for parents whose infants were admitted to a neonatal intensive care unit. Psychosomatics, 55(6), 613-620. doi: 10.1016/j.psym.2013.12.007

Shah, P. S., Lee, S. K., Lui, K., Sjörs, G., Mori, R., Reichman, B., … Darlow, B., … on behalf of the International Network for Evaluating Outcomes of Neonates (iNeo). (2014). The International Network for Evaluating Outcomes of very low birth weight, very preterm neonates (iNeo): A protocol for collaborative comparisons of international health services for quality improvement in neonatal care. BMC Pediatrics, 14(1), 110. doi: 10.1186/1471-2431-14-110

Prickett, T. C. R., Hector-Taylor, J., Olney, R. C., Darlow, B. A., & Espiner, E. A. (2013). Acute inflammation in young children inhibits C-type natriuretic peptide. Pediatric Research, 74(2), 191-195. doi: 10.1038/pr.2013.92

Austin, N., Darlow, B. A., & McGuire, W. (2013). Prophylactic oral/topical non-absorbed antifungal agents to prevent invasive fungal infection in very low birth weight infants (Review). Cochrane Database of Systematic Reviews, 3, CD003478. doi: 10.1002/14651858.CD003478.pub4

Darlow, B. A., Horwood, L. J., Pere-Bracken, H. M., & Woodward, L. J. (2013). Psychosocial outcomes of young adults born very low birth weight. Pediatrics, 132(6), e1521-e1528. doi: 10.1542/peds.2013-2024

Martin, A. J., Darlow, B. A., Salt, A., Hague, W., Sebastian, L., McNeill, N., & Tarnow-Mordi, W. (2013). Performance of the Parent Report of Children's Abilities-Revised (PARCA-R) versus the Bayley Scales of Infant Development III. Archives of Disease in Childhood, 98(12), 955-958. doi: 10.1136/archdischild-2012-303288

Jacobs, S. E., Tobin, J. M., Opie, G. F., Donath, S., Tabrizi, S. N., Pirotta, M., … for the ProPrems Study Group, including Darlow, B. A. (2013). Probiotic effects on late-onset sepsis in very preterm infants: A randomized controlled trial. Pediatrics, 132(6), 1055-1062. doi: 10.1542/peds.2013-1339

Darlow, B. A., Gilbert, C. E., & Quiroga, A. M. (2013). Setting up and improving retinopathy of prematurity programs: Interaction of neonatology, nursing, and ophthalmology. Clinics in Perinatology, 40(2), 215-227. doi: 10.1016/j.clp.2013.02.006

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