Accessibility Skip to Global Navigation Skip to Local Navigation Skip to Content Skip to Search Skip to Site Map Menu

Scientific Officer (Proteomics)

Louise Paton

PhD(Cant)

Email louise.paton@otago.ac.nz
Tel +64 3 364 0566

Research interests

Dr Louise Paton graduated from the University of Canterbury with a double major BSc in Biochemistry and Plant and Microbial Sciences. She completed her MSc in Plant Biotechnology before becoming employed as a protein chemistry technician at the Wool Research Organisation of New Zealand. She gained a Bright Future Enterprise Scholarship and completed her PhD under the supervision of Professor Juliet Gerrard in Biochemistry, specialising in proteomics and protein assembly. She worked as a Scientist at Canesis Inc before joining the Centre for Free Radical Research in 2005 as the Proteomics Research Manager.

Dr Paton is experienced in many biochemical and protein chemistry techniques including ELISA, chromatography, cell and bacterial culture. She has many years of experience in mass spectrometry, using proteins, peptides and small molecules, including both qualitative and quantitative methods and structural determination.

Dr Paton teaches the mass spectrometry tutorials and the laboratory workshop on the analysis of small molecules for the BBiomedSc(Hons) course.

^ Top of page

Publications

Peskin, A. V., Pace, P. E., Behring, J. B., Paton, L. N., Soethoudt, M., Bachschmid, M. M., & Winterbourn, C. C. (2016). Glutathionylation of the active site cysteines of peroxiredoxin 2 and recycling by glutaredoxin. Journal of Biological Chemistry, 291(6), 3053-3062. doi: 10.1074/jbc.M115.692798

Peskin, A., Pace, P., Behring, J., Paton, L., Soethoudt, M., Bachschmid, M., & Winterbourn, C. (2015). Glutathionylation at the Active Sites of Peroxiredoxin 2 and Recycling by Glutaredoxin. Free Radical Biology & Medicine, 87(Suppl. 1), (pp. 105). doi: 10.1016/j.freeradbiomed.2015.10.276

Soethoudt, M., Peskin, A. V., Dickerhof, N., Paton, L. N., Pace, P. E., & Winterbourn, C. C. (2014). Interaction of adenanthin with glutathione and thiol enzymes: Selectivity for thioredoxin reductase and inhibition of peroxiredoxin recycling. Free Radical Biology & Medicine, 77, 331-339. doi: 10.1016/j.freeradbiomed.2014.09.025

Paumann-Page, M., Furtmüller, P. G., Hofbauer, S., Paton, L. N., Obinger, C., & Kettle, A. J. (2013). Inactivation of human myeloperoxidase by hydrogen peroxide. Archives of Biochemistry & Biophysics, 539(1), 51-62. doi: 10.1016/j.abb.2013.09.004

Peskin, A. V., Dickerhof, N., Poynton, R. A., Paton, L. N., Pace, P. E., Hampton, M. B., & Winterbourn, C. C. (2013). Hyperoxidation of peroxiredoxins 2 and 3: Rate constants for the reactions of the sulfenic acid of the peroxidatic cysteine. Journal of Biological Chemistry, 288, 14170-14177. doi: 10.1074/jbc.M113.460881

Journal - Research Article

Peskin, A. V., Pace, P. E., Behring, J. B., Paton, L. N., Soethoudt, M., Bachschmid, M. M., & Winterbourn, C. C. (2016). Glutathionylation of the active site cysteines of peroxiredoxin 2 and recycling by glutaredoxin. Journal of Biological Chemistry, 291(6), 3053-3062. doi: 10.1074/jbc.M115.692798

Soethoudt, M., Peskin, A. V., Dickerhof, N., Paton, L. N., Pace, P. E., & Winterbourn, C. C. (2014). Interaction of adenanthin with glutathione and thiol enzymes: Selectivity for thioredoxin reductase and inhibition of peroxiredoxin recycling. Free Radical Biology & Medicine, 77, 331-339. doi: 10.1016/j.freeradbiomed.2014.09.025

Paumann-Page, M., Furtmüller, P. G., Hofbauer, S., Paton, L. N., Obinger, C., & Kettle, A. J. (2013). Inactivation of human myeloperoxidase by hydrogen peroxide. Archives of Biochemistry & Biophysics, 539(1), 51-62. doi: 10.1016/j.abb.2013.09.004

Peskin, A. V., Dickerhof, N., Poynton, R. A., Paton, L. N., Pace, P. E., Hampton, M. B., & Winterbourn, C. C. (2013). Hyperoxidation of peroxiredoxins 2 and 3: Rate constants for the reactions of the sulfenic acid of the peroxidatic cysteine. Journal of Biological Chemistry, 288, 14170-14177. doi: 10.1074/jbc.M113.460881

Tidén, A.-K., Sjögren, T., Svensson, M., Bernlind, A., Senthilmohan, R., Auchère, F., … Forbes, L. V., Magon, N. J., Paton, L. N., Jameson, G. N. L., … Kettle, A. J. (2011). 2-Thioxanthines are mechanism-based inactivators of myeloperoxidase that block oxidative stress during inflammation. Journal of Biological Chemistry, 286(43), 37578-37589. doi: 10.1074/jbc.M111.266981

Paton, L. N., Mocatta, T. J., Richards, A. M., & Winterbourn, C. C. (2010). Increased thrombin-induced polymerization of fibrinogen associated with high protein carbonyl levels in plasma from patients post myocardial infarction. Free Radical Biology & Medicine, 48(2), 223-229. doi: 10.1016/j.freeradbiomed.2009.10.044

Cox, A. G., Peskin, A. V., Paton, L. N., Winterbourn, C. C., & Hampton, M. B. (2009). Redox potential and peroxide reactivity of human peroxiredoxin 3. Biochemistry, 48(27), 6495-6501. doi: 10.1021/bi900558g

Paton, L. N., Gerrard, J. A., & Bryson, W. G. (2008). Two-dimensional gel electrophoresis of wool intermediate filament proteins. Journal of Proteomics, 71, 439-447. doi: 10.1016/j.jprot.2008.06.008

Paton, L. N., Gerrard, J. A., & Bryson, W. G. (2008). Investigations into charge heterogeneity of wool intermediate filaments proteins. Journal of Proteomics, 71, 513-529. doi: 10.1016/j.jprot.2008.08.001

Plowman, J. E., Paton, L. N., & Bryson, W. G. (2007). The differential expression of proteins in the cortical cells of wool and hair fibres. Experimental Dermatology, 16, 707-714. doi: 10.1111/j.1600-0625.2007.00576.x

Peskin, A. V., Low, F. M., Paton, L. N., Maghzal, G. J., Hampton, M. B., & Winterbourn, C. C. (2007). The high reactivity of peroxiredoxin 2 with H2O2 is not reflected in its reaction with other oxidants and thiol reagents. Journal of Biological Chemistry, 282(16), 11885-11892.

Plowman, J. E., Flanagan, L. M., Paton, L. N., Fitzgerald, A. C., Joyce, N. I., & Bryson, W. G. (2003). The effect of oxidation or alkylation on the separation of wool keratin proteins by two-dimensional gel electrophoresis. Proteomics, 3, 942-950. doi: 10.1002/pmic.200300419

^ Top of page

Conference Contribution - Published proceedings: Abstract

Peskin, A., Pace, P., Behring, J., Paton, L., Soethoudt, M., Bachschmid, M., & Winterbourn, C. (2015). Glutathionylation at the Active Sites of Peroxiredoxin 2 and Recycling by Glutaredoxin. Free Radical Biology & Medicine, 87(Suppl. 1), (pp. 105). doi: 10.1016/j.freeradbiomed.2015.10.276

Poynton, R., Peskin, A., Dickerhof, N., Paton, L., Winterbourn, C., & Hampton, M. (2012). Kinetics of peroxiredoxin 2 and 3 hyperoxidation. Proceedings of the Oxygen Theme Meeting. (pp. 14). Dunedin, New Zealand: University of Otago. Retrieved from https://www.otago.ac.nz/research/otago051864.pdf

^ Top of page

Conference Contribution - Poster Presentation (not in published proceedings)

Peskin, A. V., Dickerhof, N., Paton, L. N., Poynton, R. A., Pace, P., Hampton, M. B., & Winterbourn, C. C. (2013, August). Hyperoxidation of human peroxiredoxin 2 and 3. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

More publications...