Accessibility Skip to Global Navigation Skip to Local Navigation Skip to Content Skip to Search Skip to Site Map Menu

Matthew Doogue

Clinical Pharmacologist | Endocrinologist

BSc MB ChB DipPaed FRACP

Email matt.doogue@otago.ac.nz

Matt Doogue is a consultant physician at Christchurch Hospital in Clinical Pharmacology and General Medicine. He is a member of the Department of Medicine, University of Otago, Christchurch and convenes clinical pharmacology teaching.

His interests include adverse drug reactions, pharmacogenetics, applied pharmacokinetics and clinical decision support.

^ Top of page

Publications

Leggett, C., Giles, L., Anderson, J. J. A., Doogue, M., Couper, J., & Pena, A. S. (2019). Adherence to metformin is reduced during school holidays and weekends in children with type 1 diabetes participating in a randomised controlled trial. Archives of Disease in Childhood. Advance online publication. doi: 10.1136/archdischild-2018-316303

McNeill, R., Chin, P., Coberger, E., & Doogue, M. (2019). A randomised controlled trial of patient information leaflets as a medication counselling aid. Internal Medicine Journal, 49(3), 328-332. doi: 10.1111/imj.14038

Coller, J. K., Ramachandran, J., John, L., Tuke, J., Wigg, A., & Doogue, M. (2019). The impact of liver transplant recipient and donor genetic variability on tacrolimus exposure and transplant outcome [Short report]. British Journal of Clinical Pharmacology. Advance online publication. doi: 10.1111/bcp.14034

Gardiner, S. J., Metcalf, S. C. L., Chin, P. K. L., Doogue, M. P., Dalton, S. C., & Chambers, S. T. (2018). Metronidazole stewardship initiative at Christchurch hospitals: Achievable with immediate benefits. New Zealand Medical Journal, 131(1473), 53-58. Retrieved from https://www.nzma.org.nz/journal

Currow, D. C., Ekström, M., Louw, S., Hill, J., Fazekas, B., Clark, K., … Doogue, M., … Agar, M. (2018). Sertraline in symptomatic chronic breathlessness: A double blind, randomised trial. European Respiratory Journal. Advance online publication. doi: 10.1183/13993003.01270-2018

Authored Book - Other

Beard, M. E. J., Thwaites, J. H., Chambers, S. T., Colls, B. M., Doogue, M., Jeffery, M., … Pithie, A., … Sainsbury, R. (2005). Management guidelines for common medical conditions (11th ed.). Christchurch, NZ: Canterbury District Health Board, 271p.

^ Top of page

Edited Book - Other

Begg, E., Barclay, M., Vella-Brincat, J., Gardiner, S. J., Doogue, M., McDermott, L., … Chambers, S., & Murdoch, D. (Eds.). (2004). Preferred Medicines List (8th ed.). Christchurch: The Caxton Press, 172p.

^ Top of page

Journal - Research Article

Leggett, C., Giles, L., Anderson, J. J. A., Doogue, M., Couper, J., & Pena, A. S. (2019). Adherence to metformin is reduced during school holidays and weekends in children with type 1 diabetes participating in a randomised controlled trial. Archives of Disease in Childhood. Advance online publication. doi: 10.1136/archdischild-2018-316303

McNeill, R., Chin, P., Coberger, E., & Doogue, M. (2019). A randomised controlled trial of patient information leaflets as a medication counselling aid. Internal Medicine Journal, 49(3), 328-332. doi: 10.1111/imj.14038

Gardiner, S. J., Metcalf, S. C. L., Chin, P. K. L., Doogue, M. P., Dalton, S. C., & Chambers, S. T. (2018). Metronidazole stewardship initiative at Christchurch hospitals: Achievable with immediate benefits. New Zealand Medical Journal, 131(1473), 53-58. Retrieved from https://www.nzma.org.nz/journal

Currow, D. C., Ekström, M., Louw, S., Hill, J., Fazekas, B., Clark, K., … Doogue, M., … Agar, M. (2018). Sertraline in symptomatic chronic breathlessness: A double blind, randomised trial. European Respiratory Journal. Advance online publication. doi: 10.1183/13993003.01270-2018

Maggo, S. D. S., Chua, E. W., Chin, P., Cree, S., Pearson, J., Doogue, M., & Kennedy, M. A. (2017). A New Zealand platform to enable genetic investigation of adverse drug reactions. New Zealand Medical Journal, 130(1466), 62-69. Retrieved from http://www.nzma.org.nz/journal

Wright, D. F. B., Doogue, M. P., Barclay, M. L., Chapman, P. T., Cross, N. B., Irvine, J. H., & Stamp, L. K. (2017). A population pharmacokinetic model to predict oxypurinol exposure in patients on haemodialysis. European Journal of Clinical Pharmacology, 73, 71-78. doi: 10.1007/s00228-016-2133-y

Khong, J. J., Burdon, K. P., Lu, Y., Laurie, K., Leonardos, L., Baird, P. N., … Doogue, M., … Craig, J. E. (2016). Pooled genome wide association detects association upstream of FCRL3 with Graves' disease. BMC Genomics, 17(1), 939. doi: 10.1186/s12864-016-3276-z

Lewis, B. C., Nair, P. C., Heran, S. S., Somogyi, A. A., Bowden, J. J., Doogue, M. P., & Miners, J. O. (2016). Warfarin resistance associated with genetic polymorphism of VKORC1: Linking clinical response to molecular mechamism using computational modeling. Pharmacogenetics & Genomics, 26(1), 44-50. doi: 10.1097/FPC.0000000000000184

Sanderson, C., Quinn, S. J., Agar, M., Chye, R., Clark, K., Doogue, M., … Currow, D. C. (2016). Pharmacovigilance in hospice/palliative care: Net effect of pregabalin for neuropathic pain. BMJ Supportive & Palliative Care, 6(3), 323-330. doi: 10.1136/bmjspcare-2014-000825

Chin, P. K. L., & Doogue, M. P. (2016). Long-term prescribing of new oral anticoagulants. Australian Prescriber, 39(6), 200-204. doi: 10.18773/austprescr.2016.068

Chinnaratha, M. A., Chaudhary, S., Doogue, M., McCormick, R. J., Woodman, R. J., & Wigg, A. J. (2015). Prevalence of hepatic osteodystrophy and vitamin D deficiency in cirrhosis. Internal Medicine Journal, 45(12), 1230-1235. doi: 10.1111/imj.12866

Dobinson, H. C., Anderson, T. P., Chambers, S. T., Doogue, M. P., Seaward, L., & Werno, A. M. (2015). Antimicrobial treatment options for granulomatous mastitis caused by Corynebacterium species. Journal of Clinical Microbiology, 53(9), 2895-2899. doi: 10.1128/jcm.00760-15

Roberts, G. W., Quinn, S. J., Valentine, N., Alhawassi, T., O'Dea, H., Stranks, S. N., … Doogue, M. P. (2015). Relative hyperglycemia, a marker of critical illness: Introducing the Stress Hyperglycemia Ratio. Journal of Clinical Endocrinology & Metabolism, 100(12), 4490-4497. doi: 10.1210/jc.2015-2660

Sanderson, C., Quinn, S. J., Agar, M., Chye, R., Clark, K., Doogue, M., … Currow, D. C. (2015). Pharmacovigilance in hospice/palliative care: Net effect of gabapentin for neuropathic pain. BMJ Supportive & Palliative Care, 5, 273-280. doi: 10.1136/bmjspcare-2014-000699

Chin, P. K. L., Wright, D. F. B., Patterson, D. M., Doogue, M. P., & Begg, E. J. (2014). A proposal for dose-adjustment of dabigatran etexilate in atrial fibrillation guided by thrombin time. British Journal of Clinical Pharmacology, 78(3), 599-609. doi: 10.1111/bcp.12364

Radhakutty, A., Shen, J., Hooper, A. J., Miller, S. A., Burnett, J. R., Mah, P. M., … Doogue, M. P. (2014). Quantification and genotyping of lipoprotein lipase in patients with diabetic lipaemia. Diabetic Medicine, 31(12), 1702-1707. doi: 10.1111/dme.12565

Snyder, B. D., Rowland, A., Polasek, T. M., Miners, J. O., & Doogue, M. P. (2014). Evaluation of felodipine as a potential perpetrator of pharmacokinetic drug-drug interactions. European Journal of Clinical Pharmacology, 70(9), 1115-1122. doi: 10.1007/s00228-014-1716-8

To, T. H. M., Agar, M., Shelby-James, T., Abernethy, A. P., Doogue, M., Rowett, D., … Currow, D. C. (2013). Off-label prescribing in palliative care: A cross-sectional national survey of palliative medicine doctors. Palliative Medicine, 27(4), 320-328. doi: 10.1177/0269216312464263

Burt, M. G., Mangelsdorf, B. L., Rogers, A., Ho, J. T., Lewis, J. G., Inder, W. J., & Doogue, M. P. (2013). Free and total plasma cortisol measured by immunoassay and mass spectrometry following ACTH1-24 stimulation in the assessment of pituitary patients. Journal of Clinical Endocrinology & Metabolism, 98(5), 1883-1890. doi: 10.1210/jc.2012-3576

Polasek, T. M., Patel, F., Jensen, B. P., Sorich, M. J., Wiese, M. D., & Doogue, M. P. (2013). Predicted metabolic drug clearance with increasing adult age. British Journal of Clinical Pharmacology, 75(4), 1019-1028. doi: 10.1111/j.1365-2125.2012.04446.x

Kennedy, N. A., Asser, T. L., Mountifield, R. E., Doogue, M. P., Andrews, J. M., & Bampton, P. A. (2013). Thiopurine metabolite measurement leads to changes in management of inflammatory bowel disease. Internal Medicine Journal, 43(3), 278-286. doi: 10.1111/j.1445-5994.2012.02936.x

Crawford, G. B., Agar, M., Quinn, S. J., Phillips, J., Lister, C., Michael, N., Doogue, M., … Currow, D. C. (2013). Pharmacovigilance in hospice/palliative care: Net effect of haloperidol for delirium. Journal of Palliative Medicine, 16(11), 1335-1341. doi: 10.1089/jpm.2013.0230

Currow, D. C., Vella-Brincat, J., Fazekas, B., Clark, K., Doogue, M., & Rowett, D. (2012). Pharmacovigilance in hospice/palliative care: Rapid report of net clinical effect of metoclopramide. Journal of Palliative Medicine, 15(10), 1071-1075. doi: 10.1089/jpm.2012.0111

Joseph, S. P., Ho, J. T., Doogue, M. P., & Burt, M. G. (2012). Perioperative management of the hypothalamic-pituitary-adrenal axis in patients with pituitary adenomas: An Australasian survey. Internal Medicine Journal, 42(10), 1120-1124. doi: 10.1111/j.1445-5994.2011.02582.x

Schouten, B. J., Doogue, M. P., Soule, S. G., & Hunt, P. J. (2009). Iron polymaltose-induced FGF23 elevation complicated by hypophosphataemic osteomalacia. Annals of Clinical Biochemistry, 46(2), 167-169. doi: 10.1258/acb.2008.008151

Doogue, M. P., Begg, E. J., Moore, M. P., Lunt, H., Pemberton, C. J., & Zhang, M. (2009). Metformin increases plasma ghrelin in Type 2 diabetes. British Journal of Clinical Pharmacology, 68(6), 875-882. doi: 10.1111/j.1365-2125.2009.03372.x

Lewis, J. G., möpert, B., Shand, B. I., Doogue, M. P., Soule, S. G., Frampton, C. M., & Elder, P. A. (2006). Plasma variation of corticosteroid-binding globulin and sex hormone-binding globulin. Hormone & Metabolic Research, 38, 241-245.

Gardiner, S. J., Doogue, M. P., Zhang, M., & Begg, E. J. (2006). Quantification of infant exposure to celecoxib through breast milk. British Journal of Clinical Pharmacology, 61(1), 101-104. doi: 10.1111/j.1365-2125.2005.02520.x

Jackson, N. W., Doogue, M. P., & Elliott, J. M. (1999). Priority points and cardiac events while waiting for coronary bypass surgery. Heart, 81(4), 367-373. doi: 10.1136/hrt.81.4.367

Doogue, M. P., Choong, C. K., & Frizelle, F. A. (1998). Recurrent gallstone ileus. Australian & New Zealand Journal of Surgery, 68, 755-757.

Doogue, M. P., Brett, C. N. H., & Elliott, J. M. (1997). Life and death on the waiting list for coronary bypass surgery. New Zealand Medical Journal, 110(1037).

^ Top of page

Journal - Research Other

Coller, J. K., Ramachandran, J., John, L., Tuke, J., Wigg, A., & Doogue, M. (2019). The impact of liver transplant recipient and donor genetic variability on tacrolimus exposure and transplant outcome [Short report]. British Journal of Clinical Pharmacology. Advance online publication. doi: 10.1111/bcp.14034

Okamura-Kho, A., Chuah, Q., Chin, P., & Doogue, M. (2018). Rarely a triple whammy in general medicine. New Zealand Medical Journal, 1476(131), 92-95. Retrieved from https://www.nzma.org.nz/journal

Drennan, P., Doogue, M., van Hal, S. J., & Chin, P. (2018). Bayesian therapeutic drug monitoring software: Past, present and future. International Journal of Pharmacokinetics, 3(4), 109-114. doi: 10.4155/ipk-2018-0005

Polasek, T. M., Doogue, M. P., & Thynne, T. R. J. (2018). Metformin treatment of type 2 diabetes mellitus in pregnancy: Update on safety and efficacy. Therapeutic Advances in Drug Safety, 9(6), 287-295. doi: 10.1177/2042098618769831

Watts, G. J., Clark, K., Agar, M., Davidson, P. M., McDonald, C., Lam, L. T., … Doogue, M., … on behalf of the Australian national Palliative Care Clinical Studies Collaborative (PaCCSC). (2016). Study protocol: A phase III randomised, double-blind, parallel arm, stratified, block randomised, placebo-controlled trial investigating the clinical effect and cost-effectiveness of sertraline for the palliative relief of breathlessness in people with chronic breathlessness. BMJ Open, 6(11), e013177. doi: 10.1136/bmjopen-2016-013177

Clark, K., Quinn, S. J., Doogue, M., Sanderson, C., Lovell, M., & Currow, D. C. (2015). Routine prescribing of gabapentin or pregabalin in supportive and palliative care: What are the comparative performances of the medications in a palliative care population? Supportive Care in Cancer, 23(9), 2517-2520. doi: 10.1007/s00520-015-2837-z

Doogue, M. P. (2014). A safe and effective drug? New Zealand Medical Journal, 127(1404). Retrieved from http://www.nzma.org.nz/journal

Upton, T. J., Hunt, P. J., & Doogue, M. P. (2014). Hyponatraemic seizure following arginine vasopressin for von Willebrand disease: Pernicious, predictable and preventable. Internal Medicine Journal, 44(5), 521-522. doi: 10.1111/imj.12404

Chin, P. K. L., Wright, D. F. B., Doogue, M. P., & Begg, E. J. (2014). Learning more from the dabigatran concentrations in RE-LY. JACC, 63(24), 2746-2747. doi: 10.1016/j.jacc.2013.11.069

Phillips, C. J., Doan, H., Kirkpatrick, C. M. J., Gordon, D. L., & Doogue, M. P. (2013). An educational intervention to improve vancomycin prescribing and monitoring. International Journal of Antimicrobial Agents, 41(4), 393-394. doi: 10.1016/j.ijantimicag.2012.11.010

Jones, G. R. D., Bryant, S., Fullinfaw, R., Ilett, K., Miners, J. O., Morris, R. G., & Doogue, M. P. (2013). Mass or molar? Recommendations for reporting concentrations of therapeutic drugs. Medical Journal of Australia, 198, 368-369. doi: 10.5694/mja12.10366

Thynne, T. R. J., & Doogue, M. P. (2013). A dose of paracetamol for the levothyroxine absorption test. Clinical Endocrinology, 78(6), 968-969. doi: 10.1111/cen.12211

Fazal, M. W., Doogue, M. P., Leong, R. W., Bampton, P. A., & Andrews, J. M. (2013). Allopurinol use in pregnancy in three women with inflammatory bowel disease: Safety and outcomes: A case series. BMC Gastroenterology, 13, 172. doi: 10.1186/1471-230X-13-172

Doogue, M. P., & Thynne, T. R. J. (2013). Product information for generic drugs: Old, unloved and sometimes unsafe. Internal Medicine Journal, 43(12), 1346-1348. doi: 10.1111/imj.12295

Doogue, M. P., & Polasek, T. M. (2013). The ABCD of clinical pharmacokinetics. Therapeutic Advances in Drug Safety, 4(1), 5-7. doi: 10.1177/ 2042098612469335

Doogue, M. P., & Thynne, T. R. J. (2013). What is quality of medicines? Internal Medicine Journal of Thailand, 43(10), 1057-1058. doi: 10.1111/imj.12263

Currow, D. C., Rowett, D., Doogue, M., To, T. H. M., & Abernethy, A. P. (2012). An international initiative to create a collaborative for pharmacovigilance in hospice and palliative care clinical practice. Journal of Palliative Medicine, 15(3), 282-286. doi: 10.1089/jpm.2012.9605

More publications...