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Paul Pace

Research Fellow

BSc(Hons) (London, UK), PhD (Cambridge, UK)

Email paul.pace@otago.ac.nz 
Tel +64 3 364 0898

Research interests

Dr Paul Pace previously worked at Imperial College of Science and Technology in London, before moving to the Laboratory of Molecular Biology in Cambridge, where he obtained his PhD studying DNA repair mechanisms.

His expertise is in molecular biology (cloning, mutagenesis, CRISPR applications), protein biochemistry (protein expression and purification, antibody generation and purification, immunocytochemistry, immunoprecipitation, analytical methods) and cell biology (cell culture, transfection, lentiviral expression). He teaches part of the BBiomedSc(Hons) programme, has supervised two summer students, and currently co-supervises two PhD students.

His current projects include studying the biochemistry of peroxiredoxins, including their roles in cell signalling, including the redox regulation of phosphorylation-dependent cell migration and transformation in cancer.

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Publications

Dagnell, M., Pace, P. E., Cheng, Q., Frijhoff, J., Östman, A., Arnér, E. S. J., Hampton, M. B., & Winterbourn, C. C. (2017). Thioredoxin reductase 1 and NADPH directly protect protein tyrosine phosphatase 1B from inactivation during H2O2 exposure. Journal of Biological Chemistry, 292(35), 14371-14380. doi: 10.1074/jbc.M117.793745

Peskin, A. V., Pace, P. E., Behring, J. B., Paton, L. N., Soethoudt, M., Bachschmid, M. M., & Winterbourn, C. C. (2016). Glutathionylation of the active site cysteines of peroxiredoxin 2 and recycling by glutaredoxin. Journal of Biological Chemistry, 291(6), 3053-3062. doi: 10.1074/jbc.M115.692798

Soethoudt, M., Peskin, A. V., Dickerhof, N., Paton, L. N., Pace, P. E., & Winterbourn, C. C. (2014). Interaction of adenanthin with glutathione and thiol enzymes: Selectivity for thioredoxin reductase and inhibition of peroxiredoxin recycling. Free Radical Biology & Medicine, 77, 331-339. doi: 10.1016/j.freeradbiomed.2014.09.025

Pace, P. E., Peskin, A. V., Han, M.-H., Hampton, M. B., & Winterbourn, C. C. (2013). Hyperoxidized peroxiredoxin 2 interacts with the protein disulphide isomerase ERp46. Biochemical Journal, 453, 475-485. doi: 10.1042/BJ20130030

Peskin, A. V., Dickerhof, N., Poynton, R. A., Paton, L. N., Pace, P. E., Hampton, M. B., & Winterbourn, C. C. (2013). Hyperoxidation of peroxiredoxins 2 and 3: Rate constants for the reactions of the sulfenic acid of the peroxidatic cysteine. Journal of Biological Chemistry, 288, 14170-14177. doi: 10.1074/jbc.M113.460881

Dagnell, M., Pace, P. E., Cheng, Q., Frijhoff, J., Östman, A., Arnér, E. S. J., Hampton, M. B., & Winterbourn, C. C. (2017). Thioredoxin reductase 1 and NADPH directly protect protein tyrosine phosphatase 1B from inactivation during H2O2 exposure. Journal of Biological Chemistry, 292(35), 14371-14380. doi: 10.1074/jbc.M117.793745

Journal - Research Article

Peskin, A. V., Pace, P. E., Behring, J. B., Paton, L. N., Soethoudt, M., Bachschmid, M. M., & Winterbourn, C. C. (2016). Glutathionylation of the active site cysteines of peroxiredoxin 2 and recycling by glutaredoxin. Journal of Biological Chemistry, 291(6), 3053-3062. doi: 10.1074/jbc.M115.692798

Journal - Research Article

Soethoudt, M., Peskin, A. V., Dickerhof, N., Paton, L. N., Pace, P. E., & Winterbourn, C. C. (2014). Interaction of adenanthin with glutathione and thiol enzymes: Selectivity for thioredoxin reductase and inhibition of peroxiredoxin recycling. Free Radical Biology & Medicine, 77, 331-339. doi: 10.1016/j.freeradbiomed.2014.09.025

Journal - Research Article

Pace, P. E., Peskin, A. V., Han, M.-H., Hampton, M. B., & Winterbourn, C. C. (2013). Hyperoxidized peroxiredoxin 2 interacts with the protein disulphide isomerase ERp46. Biochemical Journal, 453, 475-485. doi: 10.1042/BJ20130030

Journal - Research Article

Peskin, A. V., Dickerhof, N., Poynton, R. A., Paton, L. N., Pace, P. E., Hampton, M. B., & Winterbourn, C. C. (2013). Hyperoxidation of peroxiredoxins 2 and 3: Rate constants for the reactions of the sulfenic acid of the peroxidatic cysteine. Journal of Biological Chemistry, 288, 14170-14177. doi: 10.1074/jbc.M113.460881

Journal - Research Article

Karton, A., Nagy, P., Betz, A., Peskin, A. V., Pace, P., O'Reilly, R. J., Hampton, M. B., … Winterbourn, C. C. (2011). Model for the exceptional reactivity of peroxiredoxins 2 and 3 with hydrogen peroxide; a kinetic and computational study. Journal of Biological Chemistry, 286(20), 18048-18055. doi: 10.1074/jbc.M111.232355

Journal - Research Article

Pace, P., Mosedale, G., Hodskinson, M. R., Rosado, I. V., Sivasubramaniam, M., & Patel, K. J. (2010). Ku70 corrupts DNA repair in the absence of the Fanconi anemia pathway. Science, 329, 219-223. doi: 10.1126/science.1192277

Journal - Research Article

Alpi, A. F., Pace, P. E., Babu, M. M., & Patel, K. J. (2008). Mechanistic insight into site-restricted monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI. Molecular Cell, 32(6), 767-777. doi: 10.1016/j.molcel.2008.12.003

Journal - Research Article

Oestergaard, V. H., Langevin, F., Kuiken, H. J., Pace, P., Niedzweidz, W., Simpson, L. J., … Patel, K. J. (2007). Deubiquitination of FANCD2 is required for DNA crosslink repair. Molecular Cell, 28(5), 798-809. doi: 10.1016/j.molcel.2007.09.020

Journal - Research Article

Pace, P. E., Peskin, A. V., Han, M.-H., Hampton, M. B., & Winterbourn, C. C. (2013, August). Hyperoxidized peroxiredoxin 2 interacts with the protein disulphide isomerase ERp46. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Conference Contribution - Poster Presentation (not in published proceedings)

Peskin, A. V., Dickerhof, N., Paton, L. N., Poynton, R. A., Pace, P., Hampton, M. B., & Winterbourn, C. C. (2013, August). Hyperoxidation of human peroxiredoxin 2 and 3. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Conference Contribution - Poster Presentation (not in published proceedings)

Pace, P. E., Peskin, A. V., Hampton, M. B., & Winterbourn, C. C. (2012). Hydrogen peroxide dependent interaction of peroxiredoxin 2 with ERp46. Free Radical Biology & Medicine, 53(Suppl. 1), (pp. S210). doi: 10.1016/j.freeradbiomed.2012.08.440

Conference Contribution - Published proceedings: Abstract

Peskin, A. V., Dickerhof, N., Poynton, R. A., Pace, P., Hampton, M. B., & Winterbourn, C. C. (2012). Kinetics of hyperoxidation of human peroxiredoxin 2. Free Radical Biology & Medicine, 53(Suppl. 1), (pp. S210-S211). doi: 10.1016/j.freeradbiomed.2012.08.441

Conference Contribution - Published proceedings: Abstract

Pace, P. (2011, September). Hydrogen peroxide-dependent interaction of Peroxiredoxin 2 with ERp46. Poster session presented at the European Science Federation and European Molecular Biology Organization (ESF-EMBO) Symposium: Glutathione and Related Thiols in Living Cells, Sant Feliu de Guixols, Spain.

Conference Contribution - Poster Presentation (not in published proceedings)

Pace, P. (2010, April). Fanconi anaemia protein activities disrupt Ku70 activity during the repair of crosslinked DNA. Invited seminar at the Agriculture and Life Sciences Seminar, Lincoln University, New Zealand. [Invited Presentation].

Other Research Output

Pace, P. E., Hampton, M. B., & Winterbourn, C. C. (2010, November-December). Cellular interactions of peroxiredoxin 2. Verbal presentation at the Society for Free Radical Research (SFRR) Australasia 19th Annual Conference, Akaroa, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Pace, P. (2010, August-September). Fanconi anaemia protein activities disrupt Ku70 activity during the repair of crosslinked DNA. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Pace, P., Hampton, M., & Winterbourn, C. (2009, December). Cellular interactions of peroxiredoxins. Poster session presented at the 5th Joint Meeting of the Societies for Free Radical Research Australasia and Japan & Mutagenesis and Experimental Pathology Society of Australia, Sydney, Australia.

Conference Contribution - Poster Presentation (not in published proceedings)

Pace, P. (2008). Biochemical characterisation of the FANCD2 protein (PhD). The Open University, United Kingdom. 221p.

Awarded Doctoral Degree

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