Accessibility Skip to Global Navigation Skip to Local Navigation Skip to Content Skip to Search Skip to Site Map Menu

Associate Professor Christopher M Florkowski

Chris Florkowski

BA, MB BS, MD(Lond), MRCP(UK), FRCPA, FRACP

Email chris.florkowski@cdhb.health.nz

Associate Professor Chris Florkowski is the convener of Clinical Chemistry for the Pathology Vertical Module.

He is also a Clinical Biochemistry at the Canterbury Health Laboratories.

^ Top of page

Publications

Slow, S., Pearson, J. F., Florkowski, C. M., Elder, P. A., Lewis, J. G., Kennedy, M. A., & Murdoch, D. R. (2020). Effect of genetic factors on the response to vitamin D3 supplementation in the VIDARIS randomised controlled trial. Nutrition, 75-76, 110761. doi: 10.1016/j.nut.2020.110761

Pang, J., Chan, D. C., Hu, M., Muir, L. A., Kwok, S., Charng, M.-J., Florkowski, C. M., George, P. M., … Watts, G. F. (2019). Comparative aspects of the care of familial hypercholesterolemia in the “Ten Countries Study”. Journal of Clinical Lipidology, 13, 287-300. doi: 10.1016/j.jacl.2019.01.009

Lambie, D., Florkowski, C., Sies, C., Raizis, A., Siu, W.-K., & Towns, C. (2018). A case of hereditary coproporphyria with posterior reversible encephalopathy and novel coproporphyrinogen oxidase gene mutation c.863T>G (p.Leu288Trp). Annals of Clinical Biochemistry, 55(5), 616-619. doi: 10.1177/0004563218774597

Than, M. P., Aldous, S. J., Troughton, R. W., Pemberton, C. J., Richards, A. M., Frampton, C. M. A., Florkowski, C. M., George, P. M., … Young, J. M., … Pickering, J. W. (2018). Detectable high-sensitivity cardiac troponin within the population reference interval conveys high 5-year cardiovascular risk: An observational study. Clinical Chemistry, 64(7), 1044-1053. doi: 10.1373/clinchem.2017.285700

Hughes, R. C. E., Florkowski, C., & Gullam, J. E. (2018). Evaluation of the NZ guidelines for screening for persistent postpartum hyperglycaemia following gestational diabetes. Australian & New Zealand Journal of Obstetrics & Gynaecology, 58(4), 432-437. doi: 10.1111/ajo.12746

Slow, S., Pearson, J. F., Florkowski, C. M., Elder, P. A., Lewis, J. G., Kennedy, M. A., & Murdoch, D. R. (2020). Effect of genetic factors on the response to vitamin D3 supplementation in the VIDARIS randomised controlled trial. Nutrition, 75-76, 110761. doi: 10.1016/j.nut.2020.110761

Journal - Research Article

Pang, J., Chan, D. C., Hu, M., Muir, L. A., Kwok, S., Charng, M.-J., Florkowski, C. M., George, P. M., … Watts, G. F. (2019). Comparative aspects of the care of familial hypercholesterolemia in the “Ten Countries Study”. Journal of Clinical Lipidology, 13, 287-300. doi: 10.1016/j.jacl.2019.01.009

Journal - Research Article

Hughes, R. C. E., Florkowski, C., & Gullam, J. E. (2018). Evaluation of the NZ guidelines for screening for persistent postpartum hyperglycaemia following gestational diabetes. Australian & New Zealand Journal of Obstetrics & Gynaecology, 58(4), 432-437. doi: 10.1111/ajo.12746

Journal - Research Article

Than, M. P., Aldous, S. J., Troughton, R. W., Pemberton, C. J., Richards, A. M., Frampton, C. M. A., Florkowski, C. M., George, P. M., … Young, J. M., … Pickering, J. W. (2018). Detectable high-sensitivity cardiac troponin within the population reference interval conveys high 5-year cardiovascular risk: An observational study. Clinical Chemistry, 64(7), 1044-1053. doi: 10.1373/clinchem.2017.285700

Journal - Research Article

Chavani, O., Packert Jensen, B., Strother, R. M., Florkowski, C. M., & George, P. M. (2017). Development, validation and application of a novel liquid chromatography tandem mass spectrometry assay measuring uracil, 5,6-dihydrouracil, 5-fluorouracil, 5,6-dihydro-5-fluorouracil, α-fluoro-β-ureidopropionic acid and α-fluoro-β-alanine in human plasma. Journal of Pharmaceutical & Biomedical Analysis, 142, 125-135. doi: 10.1016/j.jpba.2017.04.055

Journal - Research Article

Pickering, J. W., Than, M. P., Cullen, L., Aldous, S., ter Avest, E., Body, R., … Florkowski, C. M., … George, P., … Pemberton, C., Richards, A. M., … Troughton, R., … Young, J. (2017). Rapid rule-out of acute myocardial infarction with a single high-sensitivity cardiac troponin T measurement below the limit of detection: A collaborative meta-analysis. Annals of Internal Medicine, 166(10), 715-724. doi: 10.7326/m16-2562

Journal - Research Article

Carey, R., Lunt, H., Heenan, H. F., Frampton, C. M. A., & Florkowski, C. M. (2016). Collection tubes containing citrate stabiliser over-estimate plasma glucose, when compared to other samples undergoing immediate plasma separation. Clinical Biochemistry, 49(18), 1406-1411. doi: 10.1016/j.clinbiochem.2016.05.017

Journal - Research Article

Hughes, R. C. E., Rowan, J., & Florkowski, C. M. (2016). Is there a role for HbA1c in pregnancy? Current Diabetes Reports, 16(1), 5. doi: 10.1007/s11892-015-0698-y

Journal - Research Article

Kennedy, H., Haack, T. B., Hartill, V., Mataković, L., Baumgartner, E. R., Potter, H., MacKay, R., … King, R., Mead, S., Crozier, I., Chan, W., Florkowski, C. M., … George, P. M., Doudney, K., & Mayr, J. A. (2016). Sudden cardiac death due to deficiency of the mitochondrial inorganic pyrophosphatase PPA2. American Journal of Human Genetics, 99(3). doi: 10.1016/j.ajhg.2016.06.027

Journal - Research Article

Than, M. P., Pickering, J. W., Aldous, S. J., Cullen, L., Frampton, C. M. A., Peacock, W. F., … Richards, A. M., Ardagh, M. W., Deely, J. M., Florkowski, C. M., George, P., Hamilton, G. J., Jardine, D. L., Troughton, R. W., … Lord, S. J. (2016). Effectiveness of EDACS versus ADAPT accelerated diagnostic pathways for chest pain: A pragmatic randomized controlled trial embedded within practice. Annals of Emergency Medicine, 68(1), 93-102. doi: 10.1016/j.annemergmed.2016.01.001

Journal - Research Article

Chew-Harris, J. S. C., Chin, P. K. L., Florkowski, C. M., George, P., & Endre, Z. (2015). Removal of body surface area normalisation improves raw-measured glomerular filtration rate estimation by the Chronic Kidney Disease Epidemiology Collaboration equation and drug dosing in the obese. Internal Medicine Journal, 45(7), 766-773. doi: 10.1111/imj.12791

Journal - Research Article

Chew-Harris, J. S. C., Florkowski, C. M., George, P. M., & Endre, Z. H. (2015). Comparative performances of the new chronic kidney disease epidemiology equations incorporating cystatin C for use in cancer patients. Asia-Pacific Journal of Clinical Oncology, 11(2), 142-151. doi: 10.1111/ajco.12312

Journal - Research Article

Chin, P. K. L., Chew-Harris, J. S. C., Florkowski, C. M., & Begg, E. J. (2015). The performance of contemporary cystatin C-based GFR equations in predicting gentamicin clearance. British Journal of Clinical Pharmacology, 79(2), 268-277. doi: 10.1111/bcp.12501

Journal - Research Article

McEntyre, C. J., Lever, M., Chambers, S. T., George, P. M., Slow, S., Elmslie, J. L., Florkowski, C. M., Lunt, H., & Krebs, J. D. (2015). Variation of betaine, N,N-dimethylglycine, choline, glycerophosphorylcholine, taurine, and trimethylamine-N-oxide in the plasma and urine of overweight people with type 2 diabetes over a two-year period. Annals of Clinical Biochemistry, 52(3), 352-360. doi: 10.1177/0004563214545346

Journal - Research Article

Aldous, S., Richards, A. M., George, P. M., Cullen, L., Parsonage, W. A., Flaws, D., Florkowski, C. M., Troughton, R. W., … Than, M. (2014). Comparison of new point-of-care troponin assay with high sensitivity troponin in diagnosing myocardial infarction. International Journal of Cardiology, 177(1), 182-186. doi: 10.1016/j.ijcard.2014.09.026

Journal - Research Article

Chan, H., Lunt, H., Thompson, H., Heenan, H. F., Frampton, C. M. A., & Florkowski, C. M. (2014). Plasma glucose measurement in diabetes: Impact and implications of variations in sample collection procedures with a focus on the first hour after sample collection. Clinical Chemistry & Laboratory Medicine, 52(7), 1061-1068. doi: 10.1515/cclm-2013-1059

Journal - Research Article

Chew-Harris, J. S. C., Florkowski, C. M., Elmslie, J. L., Livesey, J., Endre, Z. H., & George, P. M. (2014). Lean mass modulates glomerular filtration rate in males of normal and extreme body composition. Internal Medicine Journal, 44(8), 749-756. doi: 10.1111/imj.12479

Journal - Research Article

Cullen, L., Aldous, S., Than, M., Greenslade, J. H., Tate, J. R., George, P. M., … Richards, A. M., Ungerer, J. P. J., Troughton, R. W., … Pemberton, C. J., Florkowski, C., … Parsonage, W. A. (2014). Comparison of high sensitivity troponin T and I assays in the diagnosis of non-ST elevation acute myocardial infarction in emergency patients with chest pain. Clinical Biochemistry, 47(6), 321-326. doi: 10.1016/j.clinbiochem.2013.11.019

Journal - Research Article

Parwaiz, M., Lunt, H., Florkowski, C. M., Logan, F. J., Irons, L., Perwick, C., Frampton, C. M. A., & Moore, M. P. (2014). Assessment of glucose meter performance at the antenatal diabetes clinic: Exploration of patient-related and pre-analytical factors. Annals of Clinical Biochemistry, 51(1), 47-53. doi: 10.1177/0004563213487893

Journal - Research Article

Scragg, R., Slow, S., Stewart, A. W., Jennings, L. C., Chambers, S. T., Priest, P. C., Florkowski, C. M., … Murdoch, D. R. (2014). Long-term high-dose vitamin D3 supplementation and blood pressure in healthy adults: A randomized controlled trial. Hypertension, 64, 725-730. doi: 10.1161/hypertensionaha.114.03466

Journal - Research Article

Slow, S., Florkowski, C. M., Chambers, S. T., Priest, P. C., Stewart, A. W., Jennings, L. C., … Murdoch, D. R. (2014). Effect of monthly vitamin D3 supplementation in healthy adults on adverse effects of earthquakes: Randomised controlled trial. BMJ, 349, g7260. doi: 10.1136/bmj.g7260

Journal - Research Article

Slow, S., Priest, P. C., Chambers, S. T., Stewart, A. W., Jennings, L. C., Florkowski, C. M., … Murdoch, D. R. (2014). Effect of vitamin D3 supplementation on Staphylococcus aureus nasal carriage: A randomized, double-blind, placebo-controlled trial in healthy adults. Clinical Microbiology & Infection, 20(5), 453-458. doi: 10.1111/1469-0691.12350

Journal - Research Article

Than, M., Aldous, S., Lord, S. J., Goodacre, S., Frampton, C. M. A., Troughton, R., George, P., Florkowski, C. M., Ardagh, M., Smyth, D., Jardine, D. L., … Young, J., Hamilton, G., Deely, J. M., … Richards, A. M. (2014). A 2-hour diagnostic protocol for possible cardiac chest pain in the emergency department: A randomized clinical trial. JAMA Internal Medicine, 174(1), 51-58. doi: 10.1001/jamainternmed.2013.11362

Journal - Research Article

Chew-Harris, J. S. C., Florkowski, C. M., George, P. M., Elmslie, J. L., & Endre, Z. H. (2013). The relative effects of fat versus muscle mass on cystatin C and estimates of renal function in healthy young men. Annals of Clinical Biochemistry, 50(1), 39-46. doi: 10.1258/acb.2012.011241

Journal - Research Article

Chin, P. K. L., Florkowski, C. M., & Begg, E. J. (2013). The performances of the Cockcroft-Gault, Modification of Diet in Renal Disease Study and Chronic Kidney Disease Epidemiology Collaboration equations in predicting gentamicin clearance. Annals of Clinical Biochemistry, 50(6), 546-557. doi: 10.1177/0004563213492320

Journal - Research Article

Cullen, L., Mueller, C., Parsonage, W. A., Wildi, K., Greenslade, J. H., Twerenbold, R., Aldous, S., … Troughton, R., … George, P., … Pemberton, C. J., Richards, A. M., … Florkowski, C., Deely, J. M., & Than, M. (2013). Validation of high-sensitivity troponin I in a 2-hour diagnostic strategy to assess 30-day outcomes in emergency department patients with possible acute coronary syndrome. JACC, 62(14), 1242-1249. doi: 10.1016/j.jacc.2013.02.078

Journal - Research Article

Swaminathan, A., Lunt, H., Chang, W. S. J., Logan, F. J., Frampton, C. M. A., & Florkowski, C. M. (2013). Impact of prandial status on the comparison of capillary glucose meter and venous plasma glucose measurements in healthy volunteers. Annals of Clinical Biochemistry, 50(1), 6-12. doi: 10.1258/acb.2012.012084

Journal - Research Article

Swaminathan, A., Lunt, H., Frampton, C. M. A., & Florkowski, C. M. (2013). What is the lower limit for postprandial venous plasma glucose in healthy young adults? Annals of Clinical Biochemistry, 50(6), 614-617. doi: 10.1177/0004563213481451

Journal - Research Article

Van Egmond, R., Barclay, M. L., Chin, P. K. L., Sies, C. W., & Florkowski, C. M. (2013). Biological variation of thiopurine methyltransferase enzyme activity: When has a significant change taken place? Annals of Clinical Biochemistry, 50(5), 473-478. doi: 10.1177/0004563212473441

Journal - Research Article

Braatvedt, G. D., Cundy, T., Crooke, M., Florkowski, C., Mann, J. I., Lunt, H., … Drury, P. L. (2012). Understanding the new HbA1c units for the diagnosis of Type 2 diabetes [Review article]. New Zealand Medical Journal, 125(1362). Retrieved from http://www.nzma.org.nz/journal

Journal - Research Article

Brennan, S. O., King, R. I., & Florkowski, C. M. (2012). β37Trp→Cys mutation leads to multiple new hemoglobin species in red cells. Clinical Biochemistry, 45, 259-263. doi: 10.1016/j.clinbiochem.2011.12.001

Journal - Research Article

Murdoch, D. R., Slow, S., Chambers, S. T., Jennings, L. C., Stewart, A. W., Priest, P. C., Florkowski, C. M., … Scragg, R. (2012). Effect of vitamin D3 supplementation on upper respiratory tract infections in healthy adults: The vidaris randomized controlled trial. JAMA, 308(13), 1333-1339. doi: 10.1001/jama.2012.12505

Journal - Research Article

Young, J. M., Florkowski, C. M., Molyneux, S. L., McEwan, R. G., Frampton, C. M., Nicholls, M. G., Scott, R. S., & George, P. M. (2012). A randomized, double-blind, placebo-controlled crossover study of coenzyme Q10 therapy in hypertensive patients with the metabolic syndrome. American Journal of Hypertension, 25(2), 261-270. doi: 10.1038/ajh.2011.209

Journal - Research Article

Young, J. M., Molyneux, S. L., Florkowski, C. M., Frampton, C. M., George, P. M., & Scott, R. S. (2012). Pharmacokinetic comparison of a generic coenzyme Q10 solubilizate and a formulation with soybean phytosterols. Phytotherapy Research, 26, 1092-1096. doi: 10.1002/ptr.3667

Journal - Research Article

Aldous, S. J., Florkowski, C. M., Crozier, I. G., Elliott, J., George, P., Lainchbury, J. G., MacKay, R. J., & Than, M. (2011). Comparison of high sensitivity and contemporary troponin assays for the early detection of acute myocardial infarction in the emergency department. Annals of Clinical Biochemistry, 48, 241-248. doi: 10.1258/acb.2010.010219

Journal - Research Article

King, R. I., Florkowski, C. M., Yeo, J., Walmsley, T. A., Shand, B. I., Scott, R. S., & George, P. M. (2011). What is the best predictor of the atherogenic LDL subclass phenotype ‘pattern B’ in patients with type 2 diabetes mellitus? Annals of Clinical Biochemistry, 48(2), 166-169. doi: 10.1258/acb.2010.010185

Journal - Research Article

Schouten, B. J., Raizis, A. M., Soule, S. G., Cole, D. R., Frengley, P. A., George, P. M., & Florkowski, C. M. (2011). Four cases of autosomal dominant hypocalcaemia with hypercalciuria including two with novel mutations in the calcium-sensing receptor gene. Annals of Clinical Biochemistry, 48(3), 286-290. doi: 10.1258/acb.2010.010139

Journal - Research Article

Young, J. M., Molyneux, S. L., Reinheimer, A. M., Florkowski, C. M., Frampton, C. M., Scott, R., & George, P. M. (2011). Relationship between plasma coenzyme Q10, asymmetric dimethylarginine and arterial stiffness in patients with phenotypic or genotypic familial hypercholesterolemia on long-term statin therapy. Atherosclerosis, 218(1), 188-193. doi: 10.1016/j.atherosclerosis.2011.04.034

Journal - Research Article

Florkowski, C., & Crooke, M. (2010). Standardisation of reporting haemoglobin A1c: Adoption of the New Zealand Society for the Study of Diabetes (NZSSD) position statement. New Zealand Medical Journal, 123(1310). Retrieved from http://journal.nzma.org.nz/journal/123-1310/4001/content.pdf

Journal - Research Article

King, R. I., & Florkowski, C. M. (2010). How paraproteins can affect laboratory assays: Spurious results and biological effects. Pathology, 42(5), 397-401. doi: 10.3109/00313025.2010.493868

Journal - Research Article

King, R. I., Scott, R. S., Florkowski, C. M., Laurie, A. D., Reid, N., & George, P. M. (2010). Homozygous familial hypercholesterolaemia and treatment by LDL apheresis [Clinical correspondence]. New Zealand Medical Journal, 123(1319). Retrieved from http://journal.nzma.org.nz/journal/123-1319/4230/content.pdf

Journal - Research Article

Lunt, H., Florkowski, C., Bignall, M., & Budgen, C. (2010). Capillary glucose meter accuracy and sources of error in the ambulatory setting. New Zealand Medical Journal, 123(1310). Retrieved from http://journal.nzma.org.nz/journal/123-1308/3945/content.pdf

Journal - Research Article

Florkowski, C., Budgen, C., Kendall, D., Lunt, H., & Moore, M. P. (2009). Comparison of blood glucose meters in a New Zealand diabetes centre. Annals of Clinical Biochemistry, 46, 302-305. doi: 10.1258/acb.2009.008193

Journal - Research Article

Molyneux, S. L., Florkowski, C. M., Richards, A. M., Lever, M., Young, J. M., & George, P. M. (2009). Coenzyme Q10: An adjunctive therapy for congestive heart failure? [Viewpoint]. New Zealand Medical Journal, 122(1305). Retrieved from http://journal.nzma.org.nz/journal/122-1305/3855/content.pdf

Journal - Research Article

Saleem, M., Lewis, J. G., Florkowski, C. M., Mulligan, G. P., George, P. M., & Hale, P. (2009). A patient with pseudo-Addison's disease and falsely elevated thyroxine due to interference in serum cortisol and free thyroxine immunoassays by two different mechanisms. Annals of Clinical Biochemistry, 46, 172-175. doi: 10.1258/acb.2008.008224

Journal - Research Article

Chew, J. S. C., Saleem, M., Florkowski, C. M., & George, P. M. (2008). Cystatin C: A paradigm of evidence based laboratory medicine. Clinical Biochemist Reviews, 29(2), 47-62.

Journal - Research Article

Dawson, S. I., Willis, J., Florkowski, C. M., & Scott, R. S. (2008). All-cause mortality in insulin-treated diabetic patients: A 20-year follow-up. Diabetes Research & Clinical Practice, 80(1), e6-e9.

Journal - Research Article

Dawson, S. I., Willis, J., Florkowski, C. M., & Scott, R. S. (2008). Cause-specific mortality in insulin-treated diabetic patients: A 20-year follow-up. Diabetes Research & Clinical Practice, 80(1), 16-23.

Journal - Research Article

Molyneux, S. L., Florkowski, C. M., George, P. M., Pilbrow, A. P., Frampton, C. M., Lever, M., & Richards, A. M. (2008). Coenzyme Q10: An independent predictor of mortality in chronic heart failure. JACC, 52(18), 1435-1441. doi: 10.1016/j.jacc.2008.07.044

Journal - Research Article

Molyneux, S. L., Young, J. M., Florkowski, C. M., Lever, M., & George, P. M. (2008). Coenzyme Q10: Is there a clinical role and a case for measurement. Clinical Biochemist Reviews, 29(2), 71-82.

Journal - Research Article

More publications...