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Karina O'ConnorResearch Fellow

MSc(Cant), PhD(Otago)

Email karina.oconnor@otago.ac.nz

Research interests

Dr Karina O'Connor is investigating a novel amyloid formation mechanism ignited by oxidation.

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Publications

Das, A. B., Seddon, A. R., O'Connor, K. M., & Hampton, M. B. (2021). Regulation of the epigenetic landscape by immune cell oxidants. Free Radical Biology & Medicine, 170, 131-149. doi: 10.1016/j.freeradbiomed.2020.12.453

O'Connor, K. M., Das, A. B., Winterbourn, C. C., & Hampton, M. B. (2020). Inhibition of DNA methylation in proliferating human lymphoma cells by immune cell oxidants. Journal of Biological Chemistry, 295(23), 7839-7848. doi: 10.1074/jbc.RA120.013092

O'Connor, K. M., Konigstorfer, A., Zawari, M., Betz, A., Heath, S., Hildebrand, J. M., … Hampton, M. (2017, September). MLKL-dependent disruption of mitochondrial function and redox homeostasis during the initiation of TNF-mediated necroptosis. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Spencer, E. S., O'Connor, K. M., & Hampton, M. B. (2017). Isothiocyanates trigger early disruption of mitochondrial function in cells overexpressing Bcl-2. Free Radical Biology & Medicine, 108(Suppl. 1), (pp. S51). doi: 10.1016/j.freeradbiomed.2017.04.185

Hampton, M. B., & O'Connor, K. M. (2016). Peroxiredoxins and the regulation of cell death. Molecules & Cells, 39(1), 72-76. doi: 10.14348/molcells.2016.2351

Das, A. B., Seddon, A. R., O'Connor, K. M., & Hampton, M. B. (2021). Regulation of the epigenetic landscape by immune cell oxidants. Free Radical Biology & Medicine, 170, 131-149. doi: 10.1016/j.freeradbiomed.2020.12.453

Journal - Research Article

O'Connor, K. M., Das, A. B., Winterbourn, C. C., & Hampton, M. B. (2020). Inhibition of DNA methylation in proliferating human lymphoma cells by immune cell oxidants. Journal of Biological Chemistry, 295(23), 7839-7848. doi: 10.1074/jbc.RA120.013092

Journal - Research Article

Abell, A. D., Brown, K. M., Coxon, J. M., Jones, M. A., Miyamoto, S., Neffe, A. T., … Stuart, B. G. (2005). Synthesis and evaluation of eight-membered cyclic pseudo-dipeptides. Peptides, 26(2), 251-258. doi: 10.1016/j.peptides.2004.09.006

Journal - Research Article

Hampton, M. B., & O'Connor, K. M. (2016). Peroxiredoxins and the regulation of cell death. Molecules & Cells, 39(1), 72-76. doi: 10.14348/molcells.2016.2351

Journal - Research Other

Spencer, E. S., O'Connor, K. M., & Hampton, M. B. (2017). Isothiocyanates trigger early disruption of mitochondrial function in cells overexpressing Bcl-2. Free Radical Biology & Medicine, 108(Suppl. 1), (pp. S51). doi: 10.1016/j.freeradbiomed.2017.04.185

Conference Contribution - Published proceedings: Abstract

Brown, K. M., Winterbourn, C. C., & Hampton, M. B. (2008). Impact of oxidative stress on DNA methylation. New Zealand Medical Journal, 121(1271). Retrieved from http://journal.nzma.org.nz/journal/121-1271/2990/content.pdf

Conference Contribution - Published proceedings: Abstract

Brown, K. M., Reeve, A. E., Hampton, M. B., & Winterbourn, C. (2006). Sensitivity of methionine adenosyltransferase to oxidation: A critical enzyme for DNA methylation. Free Radical Research, 40(Suppl. 1), P15-6, (pp. S131). [Abstract]

Conference Contribution - Published proceedings: Abstract

O'Connor, K. M., & Hampton, M. B. (2013, August). Using the Seahorse Bioscience Extracellular Flux Analyzer to measure the consequences of oxidative stress on mitochondrial function. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Conference Contribution - Poster Presentation (not in published proceedings)

Vick, K. A., Betz, A., O'Connor, K. M., Hughes, S. M., Ledgerwood, E. C., & Hampton, M. B. (2013, August). Functional consequences of lowering mitochondrial peroxiredoxin 3 expression. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Conference Contribution - Poster Presentation (not in published proceedings)

O'Connor, K. M., Konigstorfer, A., Zawari, M., Betz, A., Heath, S., Hildebrand, J. M., … Hampton, M. (2017, September). MLKL-dependent disruption of mitochondrial function and redox homeostasis during the initiation of TNF-mediated necroptosis. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

O'Connor, K. (2014, July). Using the Seahorse to measure cellular respiration during TNF-mediated cell death. Verbal presentation at the Oxygen Theme Meeting, Christchurch, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

O'Connor, K. (2008, August-September). A novel method for measuring cytosine methylation in new DNA. Verbal presentation at the Queenstown Molecular Biology Meetings, Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Brown, K. M., Winterbourn, C. C., & Hampton, M. B. (2007, August). Impact of oxidative stress on DNA methylation. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

O'Connor, K. M. (2010). The effect of oxidative stress on DNA methylation (PhD). University of Otago, Dunedin, New Zealand. 188p.

Awarded Doctoral Degree

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