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Vanessa Lattimore

Research Fellow

PhD(Otago)

Email vanessa.lattimore@otago.ac.nz  
Tel +64 3 364 0557

Research interests

Vanessa Lattimore is investigating familial breast cancer genetics by evaluating BRCA1 and BRCA2 sequence variants with modulate isoform expression.

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Publications

Brandão, R. D., Mensaert, K., López-Perolio, I., Tserpelis, D., Xenakis, M., Lattimore, V., Walker, L. C., … Blok, M. J. (2019). Targeted RNA-seq successfully identifies normal and pathogenic splicing events in breast/ovarian cancer susceptibility and Lynch syndrome genes. International Journal of Cancer. Advance online publication. doi: 10.1002/ijc.32114

Lopez-Perolio, I., Leman, R., Behar, R., Lattimore, V., Pearson, J. F., Castéra, L., … Walker, L. C., … de la Hoya, M. (2019). Alternative splicing and ACMG-AMP-2015-based classification of PALB2 genetic variants: An ENIGMA report. Journal of Medical Genetics. Advance online publication. doi: 10.1136/jmedgenet-2018-105834

Parsons, M. T., Tudini, E., Li, H., Hahnen, E., Wappenschmidt, B., Feliubadaló, L., … Lattimore, V. L., … Spurdle, A. B. (2019). Large scale multifactorial likelihood quantitative analysis of BRCA1 and BRCA2 variants: An ENIGMA resource to support clinical variant classification. Human Mutation. Advance online publication. doi: 10.1002/humu.23818

Lattimore, V. L., Pearson, J. F., Morley-Bunker, A. E., kConFab Investigators, Spurdle, A. B., Robinson, B. A., Currie, M. J., & Walker, L. C. (2019). Quantifying BRCA1 and BRCA2 mRNA isoform expression levels in single cells. International Journal of Molecular Sciences, 20(3), 693. doi: 10.3390/ijms20030693

Lattimore, V. L., Pearson, J. F., Currie, M. J., Spurdle, A. B., kConFab Investigators, Robinson, B. A., & Walker, L. C. (2018). Investigation of experimental factors that underlie BRCA1/2 mRNA isoform expression variation: Recommendations for utilising targeted RNA sequencing to evaluate potential spliceogenic variants. Frontiers in Oncology, 8, 140. doi: 10.3389/fonc.2018.00140

Journal - Research Article

Brandão, R. D., Mensaert, K., López-Perolio, I., Tserpelis, D., Xenakis, M., Lattimore, V., Walker, L. C., … Blok, M. J. (2019). Targeted RNA-seq successfully identifies normal and pathogenic splicing events in breast/ovarian cancer susceptibility and Lynch syndrome genes. International Journal of Cancer. Advance online publication. doi: 10.1002/ijc.32114

Lattimore, V. L., Pearson, J. F., Morley-Bunker, A. E., kConFab Investigators, Spurdle, A. B., Robinson, B. A., Currie, M. J., & Walker, L. C. (2019). Quantifying BRCA1 and BRCA2 mRNA isoform expression levels in single cells. International Journal of Molecular Sciences, 20(3), 693. doi: 10.3390/ijms20030693

Parsons, M. T., Tudini, E., Li, H., Hahnen, E., Wappenschmidt, B., Feliubadaló, L., … Lattimore, V. L., … Spurdle, A. B. (2019). Large scale multifactorial likelihood quantitative analysis of BRCA1 and BRCA2 variants: An ENIGMA resource to support clinical variant classification. Human Mutation. Advance online publication. doi: 10.1002/humu.23818

Lopez-Perolio, I., Leman, R., Behar, R., Lattimore, V., Pearson, J. F., Castéra, L., … Walker, L. C., … de la Hoya, M. (2019). Alternative splicing and ACMG-AMP-2015-based classification of PALB2 genetic variants: An ENIGMA report. Journal of Medical Genetics. Advance online publication. doi: 10.1136/jmedgenet-2018-105834

Lattimore, V. L., Pearson, J. F., Currie, M. J., Spurdle, A. B., kConFab Investigators, Robinson, B. A., & Walker, L. C. (2018). Investigation of experimental factors that underlie BRCA1/2 mRNA isoform expression variation: Recommendations for utilising targeted RNA sequencing to evaluate potential spliceogenic variants. Frontiers in Oncology, 8, 140. doi: 10.3389/fonc.2018.00140

de Jong, L. C., Cree, S., Lattimore, V., Wiggins, G. A. R., Spurdle, A. B., kConFab Investigators, Miller, A., Kennedy, M. A., & Walker, L. C. (2017). Nanopore sequencing of full-length BRCA1 mRNA transcripts reveals co-occurrence of known exon skipping events. Breast Cancer Research, 19, 127. doi: 10.1186/s13058-017-0919-1

de la Hoya, M., Soukarieh, O., López-Perolio, I., Vega, A., Walker, L. C., van Ierland, Y., … Lattimore, V., … Spurdle, A. B. (2016). Combined genetic and splicing analysis of BRCA1 c.[594-2A>C; 641A>G] highlights the relevance of naturally occurring in-frame transcripts for developing disease gene variant classification algorithms. Human Molecular Genetics, 25(11), 2256-2268. doi: 10.1093/hmg/ddw094

Whiley, P. J., de la Hoya, M., Thomassen, M., Becker, A., Brandão, R., Sokilde Pedersen, I., … Lattimore, V., … Walker, L., … on behalf of the ENIGMA consortium. (2014). Comparison of mRNA splicing assay protocols across multiple laboratories: Recommendations for best practice in standardized clinical testing. Clinical Chemistry, 60(2), 341-352. doi: 10.1373/clinchem.2013.210658

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Journal - Research Other

Lattimore, V., Currie, M., Lintott, C., Sullivan, J., Robinson, B. A., & Walker, L. C. (2015). Meeting the challenges of interpreting variants of unknown clinical significance in BRCA testing. New Zealand Medical Journal, 128(1419). Retrieved from http://www.nzma.org.nz/journal

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Conference Contribution - Published proceedings: Abstract

Lattimore, V., Lehnert, K., Lintott, C., Sullivan, J., Morrin, H., Robinson, B., & Walker, L. (2018). Evaluating variants in breast cancer associated genes identified by panel sequencing of New Zealand breast cancer patients. Proceedings of the New Zealand Society for Oncology (NZSO) Conference. Retrieved from http://www.nzsoncology.org.nz/

Lattimore, V., Pearson, J., Currie, M., Robinson, B., & Walker, L. (2015). Evaluating BRCA1 and BRCA2 sequence variants that modulate isoform expression. New Zealand Medical Journal, 128(1421). Retrieved from https://www.nzma.org.nz/journal

Lattimore, V., Currie, M., Robinson, B., kConFab Investigators, Spurdle, A., & Walker, L. (2013). Evaluating BRCA1 and BRCA2 sequence variants that modulate isoform expression. New Zealand Medical Journal, 126(1375). Retrieved from http://www.nzma.org.nz/journal

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Conference Contribution - Poster Presentation (not in published proceedings)

Lattimore, V. L., Lehnert, K., Lintott, C., Sullivan, J., Morrin, H., Robinson, B., & Walker, L. C. (2018, August). Evaluating variants in breast cancer associated genes identified by panel sequencing of New Zealand breast cancer patients. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Lattimore, V., Currie, M., Robinson, B., kConFab Investigators, & Walker, L. (2014, September). Evaluating BRCA1 and BRCA2 sequence variants that modulate isoform expression. Poster session presented at the Division of Health Sciences Research Forum: Learning Different Research Languages, Dunedin, New Zealand.

Lattimore, V., Currie, M., Robinson, B., kConFab Investigators, Spurdle, A., & Walker, L. (2013, September). Elevating BRCA1 and BRCA2 sequence variants that modulate isoform expression. Poster session presented at the Division of Health Sciences Research Forum: Foundations for Health: Otago Health Research, Christchurch, New Zealand.

Lattimore, V., Robinson, B., Currie, M., & Walker, L. (2012, September). Evaluating BRCA1 and BRCA2 sequence variants that modulate isoform expression. Poster session presented at the Division of Health Sciences Research Forum: Health Matters: Research Excellence at Otago, Dunedin, New Zealand.

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Conference Contribution - Verbal presentation and other Conference outputs

Lattimore, V., Pearson, J. F., Currie, M., Robinson, B. A., Spurdle, A. B., & Walker, L. C. (2015, August-September). Using splicing assays to interpret variants of unknown clinical significance in BRCA1 and BRCA2. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Lattimore, V. (2014, October). Evaluating BRCA1 and BRCA2 sequence variants that modulate isoform expression. Verbal presentation at the New Zealand Society for Oncology (NZSO) Conference, Tauranga, New Zealand.

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Awarded Doctoral Degree

Lattimore, V. (2017). Genetic variation and mRNA splicing in familial breast cancer genes (PhD). University of Otago, Dunedin, New Zealand. Retrieved from https://ourarchive.otago.ac.nz/handle/10523/7319

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