Dr George Wiggins

2024

Conference Contribution - Published proceedings: Full paper

Davidson, A., Morley-Bunker, A., Wiggins, G., Walker, L., Harris, G., Mukundan, R., & kConFab Investigators. (2024). Grey level texture features for segmentation of chromogenic dye RNAscope from breast cancer tissue. In R. Su, Y.-D. Zhang & A. F. Frangi (Eds.), International Conference on Medical Imaging and Computer-Aided Diagnosis (MICAD 2023): Lecture notes in electrical engineering (Vol. 1166). (pp. 72-82). Singapore: Springer. doi: 10.1007/978-981-97-1335-6_7

2023

Journal - Research Article

Walker, L. C., de la Hoya, M., Wiggins, G. A. R., Lindy, A., Vincent, L. M., Parsons, M. T., … & ClinGen Sequence Variant Interpretation Working Group. (2023). Using the ACMG/AMP framework to capture evidence related to predicted and observed impact on splicing: Recommendations from the ClinGen SVI Splicing Subgroup. American Journal of Human Genetics, 110(7), 1046-1067. doi: 10.1016/j.ajhg.2023.06.002

Conference Contribution - Published proceedings: Abstract

Wiggins, G. (2023). Modifiers of BRCA1-associated breast cancer risk and potential preventative strategies [Invited]. Proceedings of the Genetics Otago (GO) Annual Symposium & Workshops. Retrieved from https://blogs.otago.ac.nz/go

2022

Journal - Research Article

Hakkaart, C., Pearson, J. F., Marquart, L., Dennis, J., Wiggins, G. A. R., Barnes, D. R., Robinson, B. A., Mace, P. D., … Walker, L. C. (2022). Copy number variants as modifiers of breast cancer risk for BRCA1/BRCA2 pathogenic variant carriers. Communications Biology, 5, 1061. doi: 10.1038/s42003-022-03978-6

Crake, R. L. I., Burgess, E. R., Wiggins, G. A. R., Magon, N. J., Das, A. B., Vissers, M. C. M., Morrin, H. R., Royds, J. A., Slatter, T. L., Robinson, B. A., Phillips, E., & Dachs, G. U. (2022). Ascorbate content of clinical glioma tissues is related to tumour grade and to global levels of 5-hydroxymethyl cytosine. Scientific Reports, 12, 14845. doi: 10.1038/s41598-022-19032-8

Burgess, E. R., Crake, R. L. I., Phillips, E., Morrin, H. R., Royds, J. A., Slatter, T. L., Wiggins, G. A. R., Vissers, M. C. M., Robinson, B. A., & Dachs, G. U. (2022). Increased ascorbate content of glioblastoma is associated with a suppressed hypoxic response and improved patient survival. Frontiers in Oncology, 12, 829524. doi: 10.3389/fonc.2022.829524

2021

Journal - Research Article

Morley-Bunker, A. E., Wiggins, G. A. R., Currie, M. J., Morrin, H. R., Whitehead, M. R., Eglinton, T., Pearson, J., & Walker, L. C. (2021). RNAscope compatibility with image analysis platforms for the quantification of tissue-based colorectal cancer biomarkers in archival formalin-fixed paraffin-embedded tissue. Acta Histochemica, 123, 151765. doi: 10.1016/j.acthis.2021.151765

Wiggins, G. A. R., Black, M. A., Dunbier, A., Morley-Bunker, A. E., kConFab Investigators, Pearson, J. F., & Walker, L. C. (2021). Increased gene expression variability in BRCA1-associated and basal-like breast tumours. Breast Cancer Research & Treatment, 189, 363-375. doi: 10.1007/s10549-021-06328-y

Wiggins, G. A. R., Black, M. A., Dunbier, A., Merriman, T. R., Pearson, J. F., & Walker, L. C. (2021). Variable expression quantitative trait loci analysis of breast cancer risk variants. Scientific Reports, 11(1), 7192. doi: 10.1038/s41598-021-86690-5

McDougall, L. I., Powell, R. M., Ratajska, M., Lynch-Sutherland, C. F., Hossain, S. M., Wiggins, G. A. R., … Motwani, J., Macaulay, E. C., Reid, G., Walker, L. C., … Eccles, M. R. (2021). Differential expression of BARD1 isoforms in melanoma. Genes, 12(2), 320. doi: 10.3390/genes12020320

2020

Journal - Research Other

Wiggins, G. A. R., Walker, L. C., & Pearson, J. F. (2020). Genome-wide gene expression analyses of BRCA1- and BRCA2-associated breast and ovarian tumours. Cancers, 12(10), 3015. doi: 10.3390/cancers12103015

Conference Contribution - Published proceedings: Abstract

Wiggins, G., Pearson, J., Black, M., Dunbier, A., Merriman, T., & Walker, L. (2020). Variable expression quantitative trait loci analysis of breast cancer risk variants. New Zealand Medical Journal, 133(1524), (pp. 145). Retrieved from https://www.nzma.org.nz/journal

Awarded Doctoral Degree

Wiggins, G. A. R. (2020). Gene expression variability in breast tumour development (PhD). University of Otago, Dunedin, New Zealand. Retrieved from http://hdl.handle.net/10523/10587

2019

Journal - Research Article

Walker, L. C., Lattimore, V. L., Kvist, A., Kleiblova, P., Zemankova, P., de Jong, L., Wiggins, G. A. R., Hakkaart, C., Cree, S. L., … Kennedy, M. A., … de la Hoya, M. (2019). Comprehensive assessment of BARD1 messenger ribonucleic acid splicing with implications for variant classification. Frontiers in Genetics, 10, 1139. doi: 10.3389/fgene.2019.01139

Conference Contribution - Published proceedings: Abstract

Wiggins, G. (2019). Expression variability is associated with breast tumour subtype. Proceedings of the University of Otago Student Research Symposium: Te Wānaka Rakahau: Ākoka. Retrieved from https://www.otago.ac.nz/graduate-research

2018

Conference Contribution - Published proceedings: Abstract

Wiggins, G., Pearson, J., Black, M., Dunbier, A., & Walker, L. (2018). Expression variability is associated with breast tumour subtype. Proceedings of the New Zealand Society for Oncology (NZSO) Conference. Retrieved from http://www.nzsoncology.org.nz/

Conference Contribution - Poster Presentation (not in published proceedings)

Wiggins, G., Pearson, J., Black, M., Dunbier, A., & Walker, L. (2018, August). Expression variability is associated with breast tumour subtype. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2017

Journal - Research Article

de Jong, L. C., Cree, S., Lattimore, V., Wiggins, G. A. R., Spurdle, A. B., kConFab Investigators, Miller, A., Kennedy, M. A., & Walker, L. C. (2017). Nanopore sequencing of full-length BRCA1 mRNA transcripts reveals co-occurrence of known exon skipping events. Breast Cancer Research, 19, 127. doi: 10.1186/s13058-017-0919-1

Walker, L. C., Pearson, J. F., Wiggins, G. A. R., Giles, G. G., Hopper, J. L., & Southey, M. C. (2017). Increased genomic burden of germline copy number variants is associated with early onset breast cancer: Australian breast cancer family registry. Breast Cancer Research, 19, 30. doi: 10.1186/s13058-017-0825-6

Walker, L. C., Marquart, L., Pearson, J. F., Wiggins, G. A. R., O'Mara, T. A., Parsons, M. T., … Spurdle, A. B. (2017). Evaluation of copy-number variants as modifiers of breast and ovarian cancer risk for BRCA1 pathogenic variant carriers. European Journal of Human Genetics, 25, 432-438. doi: 10.1038/ejhg.2016.203

Conference Contribution - Published proceedings: Abstract

Pearson, J. F., Wiggins, G. A. R., Black, M., Dunbier, A., & Walker, L. C. (2017). Expression variability is associated with breast cancer tumour subtype. Proceedings of the American Society of Human Genetics (ASHG) Annual Meeting. 746. Retrieved from http://www.ashg.org/2017meeting/

2016

Journal - Research Article

Wiggins, G., & Legge, M. (2016). Cyclic variation of cellular clock proteins in the mouse estrous ovary. Journal of Reproduction & Infertility, 17(4), 192-198.

Conference Contribution - Verbal presentation and other Conference outputs

Wiggins, G. A. R., Pearson, J., Dunbier, A., Black, M., & Walker, L. (2016, August-September). Gene expression variability in breast tumours. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.

2015

Journal - Research Article

Walker, L. C., Wiggins, G. A. R., & Pearson, J. F. (2015). The role of constitutional copy number variants in breast cancer. Microarrays, 4(3), 407-423. doi: 10.3390/microarrays4030407

2014

Journal - Research Article

Chen, A., Beetham, H., Black, M. A., Priya, R., Telford, B. J., Guest, J., Wiggins, G. A. R., Godwin, T. D., … Guilford, P. J. (2014). E-cadherin loss alters cytoskeletal organization and adhesion in non-malignant breast cells but is insufficient to induce an epithelial-mesenchymal transition. BMC Cancer, 14, 552. doi: 10.1186/1471-2407-14-552

2013

Journal - Research Article

Willson, J. S. B., Godwin, T. D., Wiggins, G. A. R., Guilford, P. J., & McCall, J. L. (2013). Primary hepatocellular neoplasms in a MODY3 family with a novel HNF1A germline mutation. Journal of Hepatology, 59(4), 904-907. doi: 10.1016/j.jhep.2013.05.024

2011

Conference Contribution - Poster Presentation (not in published proceedings)

Wiggins, G., & Legge, M. (2011, September). Investigation of a molecular clock in mouse ovaries. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.