PhD CandidateResearch Interests
George Wiggins is investigating gene expression variability in breast tumour development.
His PhD supervisors are Dr Logan Walker, Dr John Pearson, Associate Professor Mik Black and Dr Anita Dunbier
Publications
Wiggins, G. A. R., Walker, L. C., & Pearson, J. F. (2020). Genome-wide gene expression analyses of BRCA1- and BRCA2-associated breast and ovarian tumours. Cancers, 12(10), 3015. doi: 10.3390/cancers12103015
Wiggins, G., Pearson, J., Black, M., Dunbier, A., Merriman, T., & Walker, L. (2020). Variable expression quantitative trait loci analysis of breast cancer risk variants. New Zealand Medical Journal, 133(1524), (pp. 145). Retrieved from https://www.nzma.org.nz/journal
Wiggins, G. A. R. (2020). Gene expression variability in breast tumour development (PhD). University of Otago, Dunedin, New Zealand. Retrieved from http://hdl.handle.net/10523/10587
Walker, L. C., Lattimore, V. L., Kvist, A., Kleiblova, P., Zemankova, P., de Jong, L., Wiggins, G. A. R., Hakkaart, C., Cree, S. L., … Kennedy, M. A., … de la Hoya, M. (2019). Comprehensive assessment of BARD1 messenger ribonucleic acid splicing with implications for variant classification. Frontiers in Genetics, 10, 1139. doi: 10.3389/fgene.2019.01139
Wiggins, G. (2019). Expression variability is associated with breast tumour subtype. Proceedings of the University of Otago Student Research Symposium: Te Wānaka Rakahau: Ākoka. Retrieved from https://www.otago.ac.nz/graduate-research
Journal - Research Article
Walker, L. C., Lattimore, V. L., Kvist, A., Kleiblova, P., Zemankova, P., de Jong, L., Wiggins, G. A. R., Hakkaart, C., Cree, S. L., … Kennedy, M. A., … de la Hoya, M. (2019). Comprehensive assessment of BARD1 messenger ribonucleic acid splicing with implications for variant classification. Frontiers in Genetics, 10, 1139. doi: 10.3389/fgene.2019.01139
Walker, L. C., Pearson, J. F., Wiggins, G. A. R., Giles, G. G., Hopper, J. L., & Southey, M. C. (2017). Increased genomic burden of germline copy number variants is associated with early onset breast cancer: Australian breast cancer family registry. Breast Cancer Research, 19, 30. doi: 10.1186/s13058-017-0825-6
de Jong, L. C., Cree, S., Lattimore, V., Wiggins, G. A. R., Spurdle, A. B., kConFab Investigators, Miller, A., Kennedy, M. A., & Walker, L. C. (2017). Nanopore sequencing of full-length BRCA1 mRNA transcripts reveals co-occurrence of known exon skipping events. Breast Cancer Research, 19, 127. doi: 10.1186/s13058-017-0919-1
Walker, L. C., Marquart, L., Pearson, J. F., Wiggins, G. A. R., O'Mara, T. A., Parsons, M. T., … Spurdle, A. B. (2017). Evaluation of copy-number variants as modifiers of breast and ovarian cancer risk for BRCA1 pathogenic variant carriers. European Journal of Human Genetics, 25, 432-438. doi: 10.1038/ejhg.2016.203
Wiggins, G., & Legge, M. (2016). Cyclic variation of cellular clock proteins in the mouse estrous ovary. Journal of Reproduction & Infertility, 17(4), 192-198.
Walker, L. C., Wiggins, G. A. R., & Pearson, J. F. (2015). The role of constitutional copy number variants in breast cancer. Microarrays, 4(3), 407-423. doi: 10.3390/microarrays4030407
Chen, A., Beetham, H., Black, M. A., Priya, R., Telford, B. J., Guest, J., Wiggins, G. A. R., Godwin, T. D., … Guilford, P. J. (2014). E-cadherin loss alters cytoskeletal organization and adhesion in non-malignant breast cells but is insufficient to induce an epithelial-mesenchymal transition. BMC Cancer, 14, 552. doi: 10.1186/1471-2407-14-552
Willson, J. S. B., Godwin, T. D., Wiggins, G. A. R., Guilford, P. J., & McCall, J. L. (2013). Primary hepatocellular neoplasms in a MODY3 family with a novel HNF1A germline mutation. Journal of Hepatology, 59(4), 904-907. doi: 10.1016/j.jhep.2013.05.024
Journal - Research Other
Wiggins, G. A. R., Walker, L. C., & Pearson, J. F. (2020). Genome-wide gene expression analyses of BRCA1- and BRCA2-associated breast and ovarian tumours. Cancers, 12(10), 3015. doi: 10.3390/cancers12103015
Conference Contribution - Published proceedings: Abstract
Wiggins, G., Pearson, J., Black, M., Dunbier, A., Merriman, T., & Walker, L. (2020). Variable expression quantitative trait loci analysis of breast cancer risk variants. New Zealand Medical Journal, 133(1524), (pp. 145). Retrieved from https://www.nzma.org.nz/journal
Wiggins, G. (2019). Expression variability is associated with breast tumour subtype. Proceedings of the University of Otago Student Research Symposium: Te Wānaka Rakahau: Ākoka. Retrieved from https://www.otago.ac.nz/graduate-research
Wiggins, G., Pearson, J., Black, M., Dunbier, A., & Walker, L. (2018). Expression variability is associated with breast tumour subtype. Proceedings of the New Zealand Society for Oncology (NZSO) Conference. Retrieved from http://www.nzsoncology.org.nz/
Pearson, J. F., Wiggins, G. A. R., Black, M., Dunbier, A., & Walker, L. C. (2017). Expression variability is associated with breast cancer tumour subtype. Proceedings of the American Society of Human Genetics (ASHG) Annual Meeting. 746. Retrieved from http://www.ashg.org/2017meeting/
Conference Contribution - Poster Presentation (not in published proceedings)
Wiggins, G., Pearson, J., Black, M., Dunbier, A., & Walker, L. (2018, August). Expression variability is associated with breast tumour subtype. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Wiggins, G., & Legge, M. (2011, September). Investigation of a molecular clock in mouse ovaries. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Wiggins, G. A. R., Pearson, J., Dunbier, A., Black, M., & Walker, L. (2016, August-September). Gene expression variability in breast tumours. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.
Awarded Doctoral Degree
Wiggins, G. A. R. (2020). Gene expression variability in breast tumour development (PhD). University of Otago, Dunedin, New Zealand. Retrieved from http://hdl.handle.net/10523/10587
