Dr Heather Shearer

2024

Journal - Research Article

Shearer, H. L., Currie, M. J., Agnew, H. N., Trappetti, C., Stull, F., Pace, P. E., … Dobson, R. C. J., & Dickerhof, N. (2024). Hypothiocyanous acid reductase is critical for host colonization and infection by Streptococcus pneumoniae. Journal of Biological Chemistry, 107282. Advance online publication. doi: 10.1016/j.jbc.2024.107282

2023

Journal - Research Article

Shearer, H. L., Pace, P. E., Smith, L. M., Fineran, P. C., Matthews, A. J., Camilli, A., Dickerhof, N., & Hampton, M. B. (2023). Identification of Streptococcus pneumoniae genes associated with hypothiocyanous acid tolerance through genome-wide screening. Journal of Bacteriology. Advance online publication. doi: 10.1128/jb.00208-23

Shearer, H. L., Loi, V. V., Weiland, P., Bange, G., Altegoer, F., Hampton, M. B., … Dickerhof, N. (2023). MerA functions as a hypothiocyanous acid reductase and defense mechanism in Staphylococcus aureus. Molecular Microbiology. Advance online publication. doi: 10.1111/mmi.15035

Conference Contribution - Published proceedings: Abstract

Shearer, H., Currie, M., Agnew, H., Trappetti, C., Stull, F., Pace, P., … Hampton, M., … Dickerhof, N. (2023). Sensitising Streptococcus pneumoniae to the immune-derived oxidant hypothiocyanous acid. Free Radical Biology & Medicine, 208(Suppl. 1), 96. doi: 10.1016/j.freeradbiomed.2023.10.110

2022

Chapter in Book - Research

Shearer, H. L., Hampton, M. B., & Dickerhof, N. (2022). Bactericidal activity of the oxidants derived from mammilian heme peroxidases. In C. L. Hawkins & W. M. Nauseef (Eds.), Mammalian heme peroxidases: Diverse roles in health and disease. (pp. 171-188). Boca Raton, FL: CRC Press. doi: 10.1201/9781003212287

Journal - Research Article

Shearer, H. L., Pace, P. E., Paton, J. C., Hampton, M. B., & Dickerhof, N. (2022). A newly identified flavoprotein disulfide reductase Har protects Streptococcus pneumoniae against hypothiocyanous acid. Journal of Biological Chemistry, 298(9), 102359. doi: 10.1016/j.jbc.2022.102359

Shearer, H. L., Kaldor, C. D., Hua, H., Kettle, A. J., Parker, H. A., & Hampton, M. B. (2022). Resistance of Streptococcus pneumoniae to hypothiocyanous acid generated by host peroxidases. Infection & Immunity, 90(3), e00530-21. doi: 10.1128/iai.00530-21

Shearer, H. L., Paton, J. C., Hampton, M. B., & Dickerhof, N. (2022). Glutathione utilization protects Streptococcus pneumoniae against lactoperoxidase-derived hypothiocyanous acid. Free Radical Biology & Medicine, 179, 24-33. doi: 10.1016/j.freeradbiomed.2021.12.261

Conference Contribution - Poster Presentation (not in published proceedings)

Shearer, H. L., Parker, H. A., Pace, P. E., Hampton, M. B., & Dickerhof, N. (2022, August). Sensitising Streptococcus pneumoniae to oxidative stress. Poster session presented at the Webster Centre for Infectious Diseases Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Shearer, H. (2022, December). A Streptococcus pneumoniae genome-wide screen identifies genes that confer tolerance to hypothiocyanous acid. Verbal presentation at the Society for Free Radical Research (SFRR) Australasia & Japan Conference: Redox Pathways in Biology & Medicine, Christchurch, New Zealand.

Awarded Doctoral Degree

Shearer, H. L. (2022). Sensitising Streptococcus pneumoniae to oxidative stress (PhD). University of Otago, Dunedin, New Zealand. Retrieved from http://hdl.handle.net/10523/12770

2021

Conference Contribution - Published proceedings: Abstract

Shearer, H. L., Parker, H. A., Paton, J., Camilli, A., Pace, P. E., Dickerhof, N., & Hampton, M. B. (2021). Sensitising Streptococcus pneumoniae to oxidative stress. Proceedings of the 16th Congress of the Federation of Asian & Oceanic Biochemists & Molecular Biologists (FAOBMB). (pp. 145). Retrieved from https://www.faobmb2021.org