Research interests
Dr Patrice Rosengrave is involved with a pilot study in the Christchurch Intensive Care Unit looking at the effects of intravenous vitamin C administration in in severe sepsis.
She was awarded a CMRF grant in 2017 to investigate the effects of vitamin C on quality of life outcomes in survivors of sepsis.
Dr Rosengrave has completed a Marsden Fast-Start project which investigated how male chinook salmon adjust sperm quality in response to social status.
Research expertise
Vitamin C, post-copulation sexual selection, cryptic female choice, sperm competition, evolutionary reproductive biology, behavioural ecology, and evolutionary proteomics.
Teaching responsibilities
Lecturing pathophysiology in Nursing Science courses:
- NURS444
- NURS427
Publications
Vlasiuk, E., Rosengrave, P., Roberts, E., Boden, J. M., Shaw, G., & Carr, A. C. (2022). Critically ill septic patients have elevated oxidative stress biomarkers: Lack of attenuation by parenteral vitamin C. Nutrition Research. Advance online publication. doi: 10.1016/j.nutres.2022.10.010
Rosengrave, P., Spencer, E., Williman, J., Mehrtens, J., Morgan, S., Doyle, T., Van Der Heyden, K., … Shaw, G., & Carr, A. C. (2022). Intravenous vitamin C administration to patients with septic shock: A pilot randomised controlled trial. Critical Care, 26(1), 26. doi: 10.1186/s13054-022-03900-w
Spencer, E., Rosengrave, P., Williman, J., Shaw, G., & Carr, A. C. (2022). Circulating protein carbonyls are specifically elevated in critically ill patients with pneumonia relative to other sources of sepsis. Free Radical Biology & Medicine, 179, 208-212. doi: 10.1016/j.freeradbiomed.2021.11.029
Carr, A., Rosengrave, P., & Spencer, E. (2021, May). Nutrition in medicine: To C or not to C (what clinical trials are telling us). UOC Research Seminar Series, University of Otago, Christchurch, New Zealand. [Department Seminar].
Carr, A. C., Bozonet, S., Pullar, J., Spencer, E., Rosengrave, P., & Shaw, G. (2021). Neutrophils isolated from septic patients exhibit elevated uptake of vitamin C and normal intracellular concentrations despite a low vitamin C milieu. Antioxidants, 10(10), 1607. doi: 10.3390/antiox10101607
Rosengrave, P., Spencer, E., Williman, J., Mehrtens, J., Morgan, S., Doyle, T., Van Der Heyden, K., … Shaw, G., & Carr, A. C. (2022). Intravenous vitamin C administration to patients with septic shock: A pilot randomised controlled trial. Critical Care, 26(1), 26. doi: 10.1186/s13054-022-03900-w
Journal - Research Article
Spencer, E., Rosengrave, P., Williman, J., Shaw, G., & Carr, A. C. (2022). Circulating protein carbonyls are specifically elevated in critically ill patients with pneumonia relative to other sources of sepsis. Free Radical Biology & Medicine, 179, 208-212. doi: 10.1016/j.freeradbiomed.2021.11.029
Journal - Research Article
Vlasiuk, E., Rosengrave, P., Roberts, E., Boden, J. M., Shaw, G., & Carr, A. C. (2022). Critically ill septic patients have elevated oxidative stress biomarkers: Lack of attenuation by parenteral vitamin C. Nutrition Research. Advance online publication. doi: 10.1016/j.nutres.2022.10.010
Journal - Research Article
Carr, A. C., Bozonet, S., Pullar, J., Spencer, E., Rosengrave, P., & Shaw, G. (2021). Neutrophils isolated from septic patients exhibit elevated uptake of vitamin C and normal intracellular concentrations despite a low vitamin C milieu. Antioxidants, 10(10), 1607. doi: 10.3390/antiox10101607
Journal - Research Article
Carr, A. C., Spencer, E., Hoskin, T. S., Rosengrave, P., Kettle, A. J., & Shaw, G. (2020). Circulating myeloperoxidase is elevated in septic shock and is associated with systemic organ failure and mortality in critically ill patients. Free Radical Biology & Medicine, 152, 462-468. doi: 10.1016/j.freeradbiomed.2019.11.004
Journal - Research Article
Johnson, S. L., Borziak, K., Kleffmann, T., Rosengrave, P., Dorus, S., & Gemmell, N. J. (2020). Ovarian fluid proteome variation associates with sperm swimming speed in an externally fertilising fish. Journal of Evolutionary Biology, 33, 1783-1794. doi: 10.1111/jeb.13717
Journal - Research Article
Bartlett, M. J., Steeves, T. E., Gemmell, N. J., & Rosengrave, P. C. (2017). Sperm competition risk drives rapid ejaculate adjustments mediated by seminal fluid. eLIFE, 6, e28811. doi: 10.7554/eLife.28811
Journal - Research Article
Carr, A. C., Rosengrave, P. C., Bayer, S., Chambers, S., Mehrtens, J., & Shaw, G. M. (2017). Hypovitaminosis C and vitamin C deficiency in critically ill patients despite recommended enteral and parenteral intakes. Critical Care, 21, 300. doi: 10.1186/s13054-017-1891-y
Journal - Research Article
Pullar, J. M., Carr, A. C., Bozonet, S. M., Rosengrave, P., Kettle, A. J., & Vissers, M. C. M. (2017). Elevated seminal plasma myeloperoxidase is associated with a decreased sperm concentration in young men. Andrology, 5(3), 431-438. doi: 10.1111/andr.12327
Journal - Research Article
Rosengrave, P., Montgomerie, R., & Gemmell, N. (2016). Cryptic female choice enhances fertilization success and embryo survival in Chinook salmon. Proceedings of the Royal Society B, 283(1827), 20160001. doi: 10.1098/rspb.2016.0001
Journal - Research Article
Johnson, S. L., Villarroel, M., Rosengrave, P., Carne, A., Kleffmann, T., Lokman, P. M., & Gemmell, N. J. (2014). Proteomic analysis of Chinook salmon (Oncorhynchus tshawytscha) ovarian fluid. PLoS ONE, 9(8), e104155. doi: 10.1371/journal.pone.0104155
Journal - Research Article
Evans, J. P., Rosengrave, P., Gasparini, C., & Gemmell, N. J. (2013). Delineating the roles of males and females in sperm competition. Proceedings of the Royal Society B, 280(1772), 20132047. doi: 10.1098/rspb.2013.2047
Journal - Research Article
Rosengrave, P., Montgomerie, R., Metcalf, V. J., McBride, K., & Gemmell, N. J. (2009). Sperm traits in Chinook salmon depend upon activation medium: Implications for studies of sperm competition in fishes. Canadian Journal of Zoology, 87(10), 920-927. doi: 10.1093/hmg/ddp442
Journal - Research Article
Rosengrave, P., Taylor, H., Montgomerie, R., Metcalf, V., McBride, K., & Gemmell, N. J. (2009). Chemical composition of seminal and ovarian fluids of chinook salmon (Oncorhynchus tshawtscha) and their effects on sperm motility traits. Comparative Biochemistry & Physiology Part A, 152, 123-129. doi: 10.1016/j.cbpa.2008.09.009
Journal - Research Article
Rosengrave, P., Gemmell, N. J., Metcalf, V., McBride, K., & Montgomerie, R. (2008). A mechanism for cryptic female choice in chinook salmon. Behavioral Ecology, 19(6), 1179-1185. doi: 10.1093/beheco/arn089
Journal - Research Article
Rowe, M., & Rosengrave, P. (2020). There and back again: A sperm's tale. Molecular Reproduction & Development, 87, 395-398. doi: 10.1002/mrd.23325
Journal - Research Other
Carr, A., Pullar, J., Forbes, L., & Rosengrave, P. (2014). Working mothers are disadvantaged by limited funding for health research. New Zealand Medical Journal, 127(1398). Retrieved from http://www.nzma.org.nz/journal
Journal - Research Other
Spencer, E., Hoskin, T., Rosengrave, P., Kettle, A., Shaw, G., & Carr, A. (2020). Circulating myeloperoxidase is elevated in septic shock and is associated with systemic organ failure and mortality in critically ill patients. New Zealand Medical Journal, 133(1524), (pp. 145-146). Retrieved from https://www.nzma.org.nz/journal
Conference Contribution - Published proceedings: Abstract
Rosengrave, P. (2013). Do females control sperm velocity and fertilisation success in Chinook salmon? Proceedings of the Centre for Reproduction and Genomics 5th Annual Research Colloquium. (pp. 12). Retrieved from http://www.otago.ac.nz/crg/news/colloquium/
Conference Contribution - Published proceedings: Abstract
Bartlett, M. J., Grassl, J., Baer, B., Steeves, T. E., Gemmell, N. J., Montgomerie, R., & Rosengrave, P. (2016, August-September). Rapid adjustment of ejaculate quality in response to sperm competition risk. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Carr, A., Rosengrave, P., & Spencer, E. (2021, May). Nutrition in medicine: To C or not to C (what clinical trials are telling us). UOC Research Seminar Series, University of Otago, Christchurch, New Zealand. [Department Seminar].
Other Research Output
Rosengrave, P. C. (2010). Ejaculate traits and ovarian fluid as a potential mechanism for cryptic female choice in chinook salmon (Oncorhynchus tshawytscha) (PhD). University of Canterbury, Christchurch, New Zealand. 140p.
Awarded Doctoral Degree