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Professor Tony Kettle

Tony Kettle

Principal Investigator, Centre for Free Radical Research
Research Professor

BSc(Hons) PhD(Otago) MSc(SFU) FRSNZ

Email tony.kettle@otago.ac.nz
Tel +64 3 364 0577

Research interests

For the past 25 years, we have probed the enzymology of myeloperoxidase (MPO). This haem protein gives pus and phlegm their characteristic green tinge. MPO produces chlorine bleach from hydrogen peroxide and common salt.

The knowledge from this work has helped us understand how white blood cells called neutrophils use MPO to kill bacteria. It has also revealed that chlorine bleach and free radicals contribute to inflammation.

We have shown that chlorine bleach promotes inflammatory tissue damage in cystic fibrosis, asthma, rheumatoid arthritis, and cardiovascular disease. In collaboration with AstraZeneca, we have also developed specific inhibitors of MPO that are potential anti-inflammatory drugs.

Current research topics


Cystic Fibrosis

Cycstic fibrosis and oxidative stress

Heart Disease

Plaque developing inside a blood vessel

Neutrophils

Bacteria killing by neutrophils

Radical Reactions

Radical Reactions

Myeloperoxidase

Mechanisms of inhibition of myeloperoxidase

Biomarkers

Biomarkers of hypochlorous acid

Public Health Lectures

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In the media

Professor Kettle was interviewed for Radio New Zealand's Our Changing World series in October 2014.