Principal Investigator
Research Professor
Email tony.kettle@otago.ac.nz
Tel +64 3 364 0577
Research interests
For the past 25 years, we have probed the enzymology of myeloperoxidase (MPO). This haem protein gives pus and phlegm their characteristic green tinge. MPO produces chlorine bleach from hydrogen peroxide and common salt.
The knowledge from this work has helped us understand how white blood cells called neutrophils use MPO to kill bacteria. It has also revealed that chlorine bleach and free radicals contribute to inflammation.
We have shown that chlorine bleach promotes inflammatory tissue damage in cystic fibrosis, asthma, rheumatoid arthritis, and cardiovascular disease. In collaboration with AstraZeneca, we have also developed specific inhibitors of MPO that are potential anti-inflammatory drugs.
Current research topics
Cystic Fibrosis  | Heart Disease  | Neutrophils  |
Radical Reactions  | Myeloperoxidase  | Biomarkers  |
Public Health Lectures
In the media
Professor Kettle was interviewed for Radio New Zealand's Our Changing World series in October 2014.
Affiliations
Publications
Inaugural Professorial Lectures
Publications
Swaminathan, A., Borichevsky, G. M., Frampton, C. M., Day, A. S., Hampton, M. B., Kettle, A. J., & Gearry, R. B. (2024). Comparison of fecal calprotectin and myeloperoxidase in predicting outcomes in inflammatory bowel disease. Inflammatory Bowel Diseases. Advance online publication. doi: 10.1093/ibd/izae032 Journal - Research Article
Paumann-Page, M., Ashby, L. V., Khalilova, I., Magon, N. J., Hofbauer, S., Paton, L. N., … Kettle, A. J. (2023). Hypochlorous acid inactivates myeloperoxidase inside phagocytosing neutrophils. Redox Biochemistry & Chemistry, 5-6, 100008. doi: 10.1016/j.rbc.2023.100008 Journal - Research Article
Ashby, L. V., Flannery, M., Chua, I., & Kettle, A. J. (2023). Measuring oxidant production in phagosomes to identify abnormalities in neutrophil function. Free Radical Biology & Medicine, 201(Suppl. 1), (pp. 13). doi: 10.1016/j.freeradbiomed.2023.03.072 Conference Contribution - Published proceedings: Abstract
Magon, N. J., Turner, R., Kettle, A. J., & Winterbourn, C. C. (2023). Cross-linking between cysteine and lysine, tryptophan or tyrosine in peptides and proteins treated with hypochlorous acid and other reactive halogens. Redox Biochemistry & Chemistry. Advance online publication. doi: 10.1016/j.rbc.2023.100002 Journal - Research Article
Kettle, A. J., Ashby, L. V., Winterbourn, C. C., & Dickerhof, N. (2023). Superoxide: The enigmatic chemical chameleon in neutrophil biology [Invited review]. Immunological Reviews, 314, 181-196. doi: 10.1111/imr.13183 Journal - Research Other
2024
Journal - Research Article
Swaminathan, A., Borichevsky, G. M., Frampton, C. M., Day, A. S., Hampton, M. B., Kettle, A. J., & Gearry, R. B. (2024). Comparison of fecal calprotectin and myeloperoxidase in predicting outcomes in inflammatory bowel disease. Inflammatory Bowel Diseases. Advance online publication. doi: 10.1093/ibd/izae032
2023
Journal - Research Article
Paumann-Page, M., Ashby, L. V., Khalilova, I., Magon, N. J., Hofbauer, S., Paton, L. N., … Kettle, A. J. (2023). Hypochlorous acid inactivates myeloperoxidase inside phagocytosing neutrophils. Redox Biochemistry & Chemistry, 5-6, 100008. doi: 10.1016/j.rbc.2023.100008
Magon, N. J., Turner, R., Kettle, A. J., & Winterbourn, C. C. (2023). Cross-linking between cysteine and lysine, tryptophan or tyrosine in peptides and proteins treated with hypochlorous acid and other reactive halogens. Redox Biochemistry & Chemistry. Advance online publication. doi: 10.1016/j.rbc.2023.100002
Journal - Research Other
Kettle, A. J., Ashby, L. V., Winterbourn, C. C., & Dickerhof, N. (2023). Superoxide: The enigmatic chemical chameleon in neutrophil biology [Invited review]. Immunological Reviews, 314, 181-196. doi: 10.1111/imr.13183
Swaminathan, A., Frampton, C. M., Borichevsky, G. M., Kettle, A. J., & Gearry, R. B. (2023). Response to "Evaluating discriminative accuracy of biomarkers in relation to binary study outcomes: First validate, then celebrate?" Journal of Crohn's & Colitis, 17, 147-148. doi: 10.1093/ecco-jcc/jjac126
Conference Contribution - Published proceedings: Abstract
Ashby, L. V., Flannery, M., Chua, I., & Kettle, A. J. (2023). Measuring oxidant production in phagosomes to identify abnormalities in neutrophil function. Free Radical Biology & Medicine, 201(Suppl. 1), (pp. 13). doi: 10.1016/j.freeradbiomed.2023.03.072
2022
Journal - Research Article
Swaminathan, A., Borichevsky, G. M., Edwards, T. S., Hirschfeld, E., Mules, T. C., Frampton, C. M. A., Day, A. S., Hampton, M. B., Kettle, A. J., & Gearry, R. B. (2022). Faecal myeloperoxidase as a biomarker of endoscopic activity in inflammatory bowel disease. Journal of Crohn's & Colitis, 16, 1862-1873. doi: 10.1093/ecco-jcc/jjac098
Ashby, L. V., Springer, R., Loi, V. V., Antelmann, H., Hampton, M. B., Kettle, A. J., & Dickerhof, N. (2022). Oxidation of bacillithiol during killing of Staphylococcus aureus USA300 inside neutrophil phagosomes. Journal of Leukocyte Biology, 112, 591-605. doi: 10.1002/jlb.4hi1021-538rr
Smyth, L. C. D., Murray, H. C., Hill, M., van Leeuwen, E., Highet, B., Magon, N. J., … Mathiesen, S. N., Mockett, B., … Clarkson, A. N., … Abraham, W. C., Hughes, S. M., … Kettle, A. J., … Hampton, M. B. (2022). Neutrophil-vascular interactions drive myeloperoxidase accumulation in the brain in Alzheimer's disease. Acta Neuropathologicca Communications, 10, 38. doi: 10.1186/s40478-022-01347-2
Shearer, H. L., Kaldor, C. D., Hua, H., Kettle, A. J., Parker, H. A., & Hampton, M. B. (2022). Resistance of Streptococcus pneumoniae to hypothiocyanous acid generated by host peroxidases. Infection & Immunity, 90(3), e00530-21. doi: 10.1128/iai.00530-21
Edwards, T. S., Dickerhof, N., Magon, N. J., Paton, L. N., Sly, P. D., & Kettle, A. J. (2022). Formation of calprotectin-derived peptides in the airways of children with cystic fibrosis. Journal of Immunology, 208, 979-990. doi: 10.4049/jimmunol.2001017
Conference Contribution - Poster Presentation (not in published proceedings)
Ashby, L. V., Dickerhof, N., Springer, R., Hampton, M. B., & Kettle, A. J. (2022, August). Bacterial resistance to oxidants in neutrophil phagosomes. Poster session presented at the Webster Centre for Infectious Diseases Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.
Dickerhof, N., Parker, H. A., Hampton, M. B., & Kettle, A. J. (2022, August). Gauging the exposure of bacteria to toxic oxidants inside neutrophil phagosomes. Poster session presented at the Webster Centre for Infectious Diseases Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Hampton, M., Kettle, T., Gladyshev, V., & Sly, P. (2022, December). Where are oxidative footprints leading us? Panel discussion at the Society for Free Radical Research (SFRR) Australasia & Japan Conference: Redox Pathways in Biology & Medicine, Christchurch, New Zealand.
2021
Journal - Research Article
Parker, H. A., Dickerhof, N., Forrester, L., Ryburn, H., Smyth, L., Messens, J., Aung, H. L., Cook, G. M., Kettle, A. J., & Hampton, M. B. (2021). Mycobacterium smegmatis resists the bactericidal activity of hypochlorous acid produced in neutrophil phagosomes. Journal of Immunology, 206, 1901-1912. doi: 10.4049/jimmunol.2001084
Conference Contribution - Published proceedings: Abstract
Borichevsky, G., Swaminathan, A., Edwards, T., Day, A., Hampton, M., Kettle, A., & Gearry, R. (2021). Faecal myeloperoxidase is a biomarker of endoscopically active inflammatory bowel disease. Proceedings of the 16th Congress of the Federation of Asian & Oceanic Biochemists & Molecular Biologists (FAOBMB). (pp. 234). Retrieved from https://www.faobmb2021.org
Kettle, A. J., Ashby, L. V., Das, A. B., Dickerhof, N., Hampton, M. B., & Winterbourn, C. C. (2021). What's so super about superoxide? Proceedings of the 16th Congress of the Federation of Asian & Oceanic Biochemists & Molecular Biologists (FAOBMB). (pp. 275). Retrieved from https://www.faobmb2021.org
2020
Journal - Research Article
Bathish, B., Paumann-Page, M., Paton, L. N., Kettle, A. J., & Winterbourn, C. C. (2020). Peroxidasin mediates bromination of tyrosine residues in the extracellular matrix. Journal of Biological Chemistry, 295(36), 12697-12705. doi: 10.1074/jbc.RA120.014504
Dickerhof, N., Paton, L., & Kettle, A. J. (2020). Oxidation of bacillithiol by myeloperoxidase-derived oxidants. Free Radical Biology & Medicine, 158, 74-83. doi: 10.1016/j.freeradbiomed.2020.06.009
Dickerhof, N., Huang, J., Min, E., Michaëlsson, E., Lindstedt, E.-L., Pearson, J. F., Kettle, A. J., & Day, B. J. (2020). Myeloperoxidase inhibition decreases morbidity and oxidative stress in mice with cystic fibrosis-like lung inflammation. Free Radical Biology & Medicine, 152, 91-99. doi: 10.1016/j.freeradbiomed.2020.03.001
Schneider, M., Hannaway, R. F., Lamichhane, R., de la Harpe, S. M., Tyndall, J. D. A., Vernall, A. J., Kettle, A. J., & Ussher, J. E. (2020). Neutrophils suppress mucosal-associated invariant T cells in humans. European Journal of Immunology, 50, 643-655. doi: 10.1002/eji.201948394
Carr, A. C., Spencer, E., Hoskin, T. S., Rosengrave, P., Kettle, A. J., & Shaw, G. (2020). Circulating myeloperoxidase is elevated in septic shock and is associated with systemic organ failure and mortality in critically ill patients. Free Radical Biology & Medicine, 152, 462-468. doi: 10.1016/j.freeradbiomed.2019.11.004
Journal - Research Other
Ashby, L. V., Springer, R., Hampton, M. B., Kettle, A. J., & Winterbourn, C. C. (2020). Evaluating the bactericidal action of hypochlorous acid in culture media [Short communication]. Free Radical Biology & Medicine, 159, 119-124. doi: 10.1016/j.freeradbiomed.2020.07.033
Conference Contribution - Published proceedings: Abstract
Spencer, E., Hoskin, T., Rosengrave, P., Kettle, A., Shaw, G., & Carr, A. (2020). Circulating myeloperoxidase is elevated in septic shock and is associated with systemic organ failure and mortality in critically ill patients. New Zealand Medical Journal, 133(1524), (pp. 145-146). Retrieved from https://www.nzma.org.nz/journal
2019
Chapter in Book - Research
Garai, D., Pálinkás, Z., Balla, J., Kettle, A. J., & Nagy, P. (2019). Measurements for sulfide-mediated inhibition of myeloperoxidase activity. In J. Beltowski (Ed.), Vascular effects of hydrogen sulfide: Methods and protocols: Methods in molecular biology (Vol. 2007). (pp. 179-203). New York, NY: Humana Press. doi: 10.1007/978-1-4939-9528-8_14
Journal - Research Article
Dickerhof, N., Isles, V., Pattemore, P., Hampton, M. B., & Kettle, A. J. (2019). Exposure of Pseudomonas aeruginosa to bactericidal hypochlorous acid during neutrophil phagocytosis is compromised in cystic fibrosis. Journal of Biological Chemistry, 294(36), 13502-13514. doi: 10.1074/jbc.RA119.009934
Cheng, D., Talib, J., Stanley, C. P., Rashid, I., Michaëlsson, E., Lindstedt, E.-L., … Kettle, A. J., … Stocker, R. (2019). Inhibition of MPO (myeloperoxidase) attenuates endothelial dysfunction in mouse models of vascular inflammation and atherosclerosis. Arteriosclerosis, Thrombosis, & Vascular Biology, 39, 1448-1457. doi: 10.1161/atvbaha.119.312725
Hoskin, T. S., Crowther, J. M., Cheung, J., Epton, M. J., Sly, P. D., Elder, P. A., … Kettle, A. J., & Dickerhof, N. (2019). Oxidative cross-linking of calprotectin occurs in vivo, altering its structure and susceptibility to proteolysis. Redox Biology, 24, 101202. doi: 10.1016/j.redox.2019.101202
Filbey, K. J., Camberis, M., Chandler, J., Turner, R., Kettle, A. J., Eichenberger, R. M., … Le Gros, G. (2019). Intestinal helminth infection promotes IL-5- and CD4+ T cell-dependent immunity in the lung against migrating parasites. Mucosal Immunology, 12, 352-362. doi: 10.1038/s41385-018-0102-8
2018
Edited Book - Research
Vissers, M. C. M., Hampton, M. B., & Kettle, A. J. (Eds.). (2018). Hydrogen peroxide metabolism in health and disease. Boca Raton, FL: CRC Press, 456p.
Chapter in Book - Research
Forbes, L. V., & Kettle, A. J. (2018). Myeloperoxidase: Unleashing the power of hydrogen peroxide. In M. C. M. Vissers, M. B. Hampton & A. J. Kettle (Eds.), Hydrogen peroxide metabolism in health and disease. (pp. 281-304). Boca Raton, FL: CRC Press.
Journal - Research Article
Turner, R., Brennan, S. O., Ashby, L. V., Dickerhof, N., Hamzah, M. R., Pearson, J. F., Stamp, L. K., & Kettle, A. J. (2018). Conjugation of urate-derived electrophiles to proteins during normal metabolism and inflammation. Journal of Biological Chemistry, 293(51), 19886-19898. doi: 10.1074/jbc.RA118.005237
Rashid, I., Maghzal, G. J., Chen, Y.-C., Cheng, D., Talib, J., Newington, D., … Kettle, A. J., … Stocker, R. (2018). Myeloperoxidase is a potential molecular imaging and therapeutic target for the identification and stabilization of high-risk atherosclerotic plaque. European Heart Journal, 39(35), 3301-3310. doi: 10.1093/eurheartj/ehy419
Albrett, A. M., Ashby, L. V., Dickerhof, N., Kettle, A. J., & Winterbourn, C. C. (2018). Heterogeneity of hypochlorous acid production in individual neutrophil phagosomes revealed by a rhodamine-based probe. Journal of Biological Chemistry, 293(40), 15715-15724. doi: 10.1074/jbc.RA118.004789
Bathish, B., Turner, R., Paumann-Page, M., Kettle, A. J., & Winterbourn, C. C. (2018). Characterisation of peroxidasin activity in isolated extracellular matrix and direct detection of hypobromous acid formation. Archives of Biochemistry & Biophysics, 646, 120-127. doi: 10.1016/j.abb.2018.03.038
Khalilova, I. S., Dickerhof, N., Mocatta, T. J., Bhagra, C. J., McClean, D. R., Obinger, C., & Kettle, A. J. (2018). A myeloperoxidase precursor, pro-myeloperoxidase, is present in human plasma and elevated in cardiovascular disease patients. PLoS ONE, 13(3), e0192952. doi: 10.1371/journal.pone.0192952
Coker, M. S., Forbes, L. V., Plowman-Holmes, M., Murdoch, D. R., Winterbourn, C. C., & Kettle, A. J. (2018). Interactions of staphyloxanthin and enterobactin with myeloperoxidase and reactive chlorine species. Archives of Biochemistry & Biophysics, 646, 80-89. doi: 10.1016/j.abb.2018.03.039
Das, A. B., Sadowska-Bartosz, I., Königstorfer, A., Kettle, A. J., & Winterbourn, C. C. (2018). Superoxide dismutase protects ribonucleotide reductase from inactivation in yeast. Free Radical Biology & Medicine, 116, 114-122. doi: 10.1016/j.freeradbiomed.2018.01.001
Forbes, L. V., & Kettle, A. J. (2018). A multi-substrate assay for finding physiologically effective inhibitors of myeloperoxidase. Analytical Biochemistry, 544, 13-21. doi: 10.1016/j.ab.2017.12.022
Journal - Professional & Other Non-Research Articles
van der Vliet, A., Dick, T. P., Aust, S. D., Koppenol, W. H., Ursini, F., Kettle, A. J., … Janssen-Heininger, Y. M. W. (2018). Rust never sleeps: The continuing story of the Iron Bolt. Free Radical Biology & Medicine, 124, 353-357. doi: 10.1016/j.freeradbiomed.2018.06.017
Conference Contribution - Published proceedings: Abstract
Albrett, A. M., Ashby, L. V., Dickerhof, N., Hampton, M. B., Winterbourn, C. C., & Kettle, A. J. (2018). Detection of hypochlorous acid in neutrophil phagosomes with the probe R19S: Chlorinated product formation and real-time fluorescence. Proceedings of the New Zealand Microbiological Society (NZMS) New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) Joint Annual Conference: Microbes & Molecules. (pp. 112-113). Retrieved from https://www.nzmsconference.org.nz
Parker, H. A., Hampton, M. B., Rosado, L. A., Messens, J., & Kettle, A. J. (2018). Resistance of Mycobacterium smegmatis to oxygen-dependent killing by neutrophils. Proceedings of the New Zealand Microbiological Society (NZMS) New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) Joint Annual Conference: Microbes & Molecules. (pp. 95-96). Retrieved from https://www.nzmsconference.org.nz
Chami, B., Vallejo, A., KumJew, S., Dickerhof, N., Kettle, A. J., Dennis, J. M., & Witting, P. (2018). Role for neutrophil-derived myeloperoxidase in promoting acute colitis; inhibition of disease progression with 4-Methoxy TEMPO. Free Radical Biology & Medicine, 120(Suppl. 1), (pp. S38). doi: 10.1016/j.freeradbiomed.2018.04.131
Conference Contribution - Poster Presentation (not in published proceedings)
Springer, R., Ashby, L., Kettle, A., Winterbourn, C., & Hampton, M. (2018, September). Staphylococcus Aureus survival inside the neutrophil phagosome. Poster session presented at the Otago Spotlight Symposium on Infectious Disease, Wellington, New Zealand.
2017
Journal - Research Article
Green, J. N., Chapman, A. L. P., Bishop, C. J., Winterbourn, C. C., & Kettle, A. J. (2017). Neutrophil granule proteins generate bactericidal ammonia chloramine on reaction with hydrogen peroxide. Free Radical Biology & Medicine, 113, 363-371. doi: 10.1016/j.freeradbiomed.2017.10.343
Dickerhof, N., Pearson, J. F., Hoskin, T. S., Berry, L. J., Turner, R., Sly, P. D., Kettle, A. J., on behalf of AREST CF. (2017). Oxidative stress in early cystic fibrosis lung disease is exacerbated by airway glutathione deficiency. Free Radical Biology & Medicine, 113, 236-243. doi: 10.1016/j.freeradbiomed.2017.09.028
Pullar, J. M., Carr, A. C., Bozonet, S. M., Rosengrave, P., Kettle, A. J., & Vissers, M. C. M. (2017). Elevated seminal plasma myeloperoxidase is associated with a decreased sperm concentration in young men. Andrology, 5(3), 431-438. doi: 10.1111/andr.12327
Dickerhof, N., Turner, R., Khalilova, I., Fantino, E., Sly, P. D., Kettle, A. J., on behalf of AREST CF. (2017). Oxidized glutathione and uric acid as biomarkers of early cystic fibrosis lung disease. Journal of Cystic Fibrosis, 16(2), 214-221. doi: 10.1016/j.jcf.2016.10.012
Conference Contribution - Verbal presentation and other Conference outputs
Dickerhof, N., Pearson, J. F., Hoskin, T. S., Sly, P. D., & Kettle, A. J. (2017, August). Myeloperoxidase is associated with bronchiectasis in children with cystic fibrosis. Verbal presentation at the 10th International Human Peroxidase Meeting, Breckenridge, USA.
Forbes, L. V., Konigstorfer, A., Gray, M. J., Jakob, U., Kettle, A. J., Hampton, M. B., & Winterbourn, C. C. (2017, July). Bacterial resistance to neutrophil-derived oxidants. Verbal presentation at the New Zealand Branch of the Australasian Society for Immunology (NZ ASI) Annual Scientific Meeting, Christchurch, New Zealand.
Hoskin, T. S., Dickerhof, N., Hampton, M. B., & Kettle, A. J. (2017, July). Calprotectin is sensitive to oxidants generated by myeloperoxidase. Verbal presentation at the New Zealand Branch of the Australasian Society for Immunology (NZ ASI) Annual Scientific Meeting, Christchurch, New Zealand.
2016
Chapter in Book - Research
Kettle, A. J., & Winterbourn, C. C. (2016). Myeloperoxidase: Structure and function of the green heme peroxidase of neutrophils. In E. Raven & B. Dunford (Eds.), Heme peroxidases. (pp. 272-308). Cambridge, UK: Royal Society of Chemistry. doi: 10.1039/9781782622628-00272
Journal - Research Article
Kato, Y., Oki, K., Suga, N., Ono, S., Ishisaka, A., Miura, Y., … Kettle, A. J. (2016). A novel quinone derived from 5-hydroxyindoleacetic acid reacts with protein: Possible participation of oxidation of serotonin and its metabolite in the development of atherosclerosis. Free Radical Biology & Medicine, 101, 500-510. doi: 10.1016/j.freeradbiomed.2016.11.023
Terrill, J. R., Duong, M. N., Turner, R., Le Guiner, C., Boyatzis, A., Kettle, A. J., … Arthur, P. G. (2016). Levels of inflammation and oxidative stress, and a role for taurine in dystropathology of the Golden Retriever Muscular Dystrophy dog model for Duchenne Muscular Dystrophy. Redox Biology, 9, 276-286. doi: 10.1016/j.redox.2016.08.016
Journal - Research Other
Winterbourn, C. C., Kettle, A. J., & Hampton, M. B. (2016). Reactive oxygen species and neutrophil function. Annual Review of Biochemistry, 85, 765-792. doi: 10.1146/annurev-biochem-060815-014442
Conference Contribution - Published proceedings: Abstract
Dickerhof, N., Berry, L. J., Turner, R., Hoskin, T., Sly, P. D., & Kettle, A. J. (2016). Glutathione deficiency and neutrophil-mediated oxidative stress in the lungs of young children with cystic fibrosis. Free Radical Biology & Medicine, 100(Suppl.), (pp. S190). doi: 10.1016/j.freeradbiomed.2016.10.519
Cheng, D., Chen, Y. C., Stanley, C., Talib, J., Rashid, I., Lindstedt, E.-L., Kettle, A. J., … Stocker, R. (2016). Pharmacological inhibition of myeloperoxidase improves endothelial function and stabilizes atherosclerotic lesions in a mouse model of vulnerable plaque. Free Radical Biology & Medicine, 100(Suppl.), (pp. S151-S152). doi: 10.1016/j.freeradbiomed.2016.10.399
Bathish, B., Turner, R., Kettle, T., & Winterbourn, C. (2016). Peroxidasin-catalysed oxidative modifications of proteins in the extracellular matrix. Free Radical Biology & Medicine, 100(Suppl.), (pp. S19-S20). doi: 10.1016/j.freeradbiomed.2016.10.044
2015
Journal - Research Article
Dickerhof, N., Schindler, L., Bernhagen, J., Kettle, A. J., & Hampton, M. B. (2015). Macrophage migration inhibitory factor (MIF) Is rendered enzymatically inactive by myeloperoxidase-derived oxidants but retains its immunomodulatory function. Free Radical Biology & Medicine, 89, 498-511. doi: 10.1016/j.freeradbiomed.2015.09.009
Patrício, E. S., Prado, F. M., da Silva, R. P., Carvalho, L. A. C., Prates, M. V. C., Dadamos, T., … Kettle, A. J., & Meotti, F. C. (2015). Chemical characterization of urate hydroperoxide, A pro-oxidant intermediate generated by urate oxidation in inflammatory and photoinduced processes. Chemical Research in Toxicology, 28(8), 1556-1566. doi: 10.1021/acs.chemrestox.5b00132
Chandler, J. D., Min, E., Huang, J., McElroy, C. S., Dickerhof, N., Mocatta, T., … Kettle, A. J., … Day, B. J. (2015). Antiinflammatory and antimicrobial effects of thiocyanate in a cystic fibrosis mouse model. American Journal of Respiratory Cell & Molecular Biology, 53(2), 193-205. doi: 10.1165/rcmb.2014-0208OC
Odobasic, D., Muljadi, R. C. M., O'Sullivan, K. M., Kettle, A. J., Dickerhof, N., Summers, S. A., … Holdsworth, S. R. (2015). Suppression of autoimmunity and renal disease in pristane-induced lupus by myeloperoxidase. Arthritis & Rheumatology, 67(7), 1868-1880. doi: 10.1002/art.39109
Magon, N. J., Turner, R., Gearry, R. B., Hampton, M. B., Sly, P. D., & Kettle, A. J. (2015). Oxidation of calprotectin by hypochlorous acid prevents chelation of essential metal ions and allows bacterial growth: Relevance to infections in cystic fibrosis. Free Radical Biology & Medicine, 86, 133-144. doi: 10.1016/j.freeradbiomed.2015.05.022
Wilkie-Grantham, R. P., Magon, N. J., Harwood, D. T., Kettle, A. J., Vissers, M. C., Winterbourn, C. C., & Hampton, M. B. (2015). Myeloperoxidase-dependent lipid peroxidation promotes the oxidative modification of cytosolic proteins in phagocytic neutrophils. Journal of Biological Chemistry, 290(15), 9896-9905. doi: 10.1074/jbc.M114.613422
Conference Contribution - Published proceedings: Abstract
Patricio, E., Prates, M., Prado, F., Dadamos, T., Carvalho, L. A. D. C., Bertotti, M., … Kettle, A. J., & Meotti, F. C. (2015). Urate hydroperoxide as a pro-oxidant intermediate generated by urate oxidation in inflammatory and photo-induced processes. Proceedings of the 250th National American Chemical Society (ACS) Fall Meeting. Retrieved from https://www.acs.org
Spencer, E., Dickerhof, N., Tyndall, J., Bernhagen, J., Kettle, A., & Hampton, M. (2015). Assessing inhibition of macrophage migration inhibitory factor by isothiocyanates. Free Radical Biology & Medicine, 86(Suppl. 1), (pp. S42-S43). doi: 10.1016/j.freeradbiomed.2015.07.145
Nagy, P., Das, A., Nauser, T., Koppenol, W. H., Kettle, A. J., & Winterbourn, C. C. (2015). Superoxide-mediated post-translational modification of tyrosine residues. Free Radical Biology & Medicine, 86(Suppl. 1), (pp. S17-S18). doi: 10.1016/j.freeradbiomed.2015.07.073
Brockway, B., Senthilmohan, R., Jones, S., Cowan, J., Herbison, P., Hancox, B., Taylor, R., Van Dalen, C. J., & Kettle, T. (2015). Elevated sputum 3-bromotyrsoine levels are associated with loss of control in asthma. American Journal of Respiratory & Critical Care Medicine, 191(Meeting Abstracts). Retrieved from http://www.atsjournals.org/series/ajrccm-conference
Conference Contribution - Verbal presentation and other Conference outputs
Dickerhof, N., Fantino, E., Turner, R., Sly, P., & Kettle, A. J. (2015, December). Evaluation of glutathione sulphonamide and allantoin as blood and urine based indicators of exacerbations in children with cystic fibrosis. Verbal presentation at the Society for Free Radical Research Australasia & Japan Seventh Joint Meeting, Christchurch, New Zealand.
Kettle, T. (2015, September). Paradoxes inside the neutrophil phagosome. Invited presentation at the 9th International Human Peroxidase Meeting, Cologne, USA.
Dickerhof, N., Kettle, A. J., & Hampton, M. B. (2015, September). Myeloperoxidase-derived oxidants render macrophage migration inhibitory factor (MIF) enzymatically inactive while retaining its immunologic function. Verbal presentation at the 9th International Human Peroxidase Meeting, Cologne, USA.
2014
Journal - Research Article
Green, J. N., Kettle, A. J., & Winterbourn, C. C. (2014). Protein chlorination in neutrophil phagosomes and correlation with bacterial killing. Free Radical Biology & Medicine, 77, 49-56. doi: 10.1016/j.freeradbiomed.2014.08.013
Kato, Y., Ono, S., Kitamoto, N., & Kettle, A. J. (2014). Covalent modification of cytoskeletal proteins in neuronal cells by tryptamine–4,5-dione. Redox Biology, 2, 983-990. doi: 10.1016/j.redox.2014.08.004
Dickerhof, N., Magon, N. J., Tyndall, J. D. A., Kettle, A. J., & Hampton, M. B. (2014). Potent inhibition of macrophage migration inhibitory factor (MIF) by myeloperoxidase-dependant oxidation of epicatechins. Biochemical Journal, 462(2), 303-314. doi: 10.1042/BJ20140612
Seidel, A., Parker, H., Turner, R., Dickerhof, N., Khalilova, I. S., Wilbanks, S. M., Kettle, A. J., & Jameson, G. N. L. (2014). Uric acid and thiocyanate as competing substrates of lactoperoxidase. Journal of Biological Chemistry, 289(32), 21937-21949. doi: 10.1074/jbc.M113.544957
Stamp, L. K., Turner, R., Khalilova, I. S., Zhang, M., Drake, J., Forbes, L. V., & Kettle, A. J. (2014). Myeloperoxidase and oxidation of uric acid in gout: Implications for the clinical consequences of hyperuricaemia. Rheumatology, 53(11), 1958-1965. doi: 10.1093/rheumatology/keu218
Rees, M. D., Maiocchi, S. L., Kettle, A. J., & Thomas, S. R. (2014). Mechanism and regulation of peroxidase-catalyzed nitric oxide consumption in physiological fluids: Critical protective actions of ascorbate and thiocyanate. Free Radical Biology & Medicine, 72, 91-103. doi: 10.1016/j.freeradbiomed.2014.03.037
Kettle, A. J., Turner, R., Gangell, C. L., Harwood, D. T., Khalilova, I. S., Chapman, A. L., Winterbourn, C. C., … on behalf of AREST CF. (2014). Oxidation contributes to low glutathione in the airways of children with cystic fibrosis. European Respiratory Journal, 44, 122-129. doi: 10.1183/09031936.00170213
Das, A. B., Nauser, T., Koppenol, W. H., Kettle, A. J., Winterbourn, C. C., & Nagy, P. (2014). Rapid reaction of superoxide with insulin-tyrosyl radicals to generate a hydroperoxide with subsequent glutathione addition. Free Radical Biology & Medicine, 70, 86-95. doi: 10.1016/j.freeradbiomed.2014.02.006
Ronsein, G. E., Winterbourn, C. C., Di Mascio, P., & Kettle, A. J. (2014). Cross-linking methionine and amine residues with reactive halogen species. Free Radical Biology & Medicine, 70, 278-287. doi: 10.1016/j.freeradbiomed.2014.01.023
Maghzal, G. J., Cergol, K. M., Shengule, S. R., Suarna, C., Newington, D., Kettle, A. J., … Stocker, R. (2014). Assessment of myeloperoxidase activity by the conversion of hydroethidine to 2-chloroethidium. Journal of Biological Chemistry, 289(9), 5580-5595. doi: 10.1074/jbc.M113.539486
Kettle, A. J., Albrett, A. M., Chapman, A. L., Dickerhof, N., Forbes, L. V., Khalilova, I., & Turner, R. (2014). Measuring chlorine bleach in biology and medicine. Biochimica et Biophysica Acta: General Subjects, 1840(2), 781-793. doi: 10.1016/j.bbagen.2013.07.004
Conference Contribution - Published proceedings: Abstract
Stamp, L. K., Chapman, P. T., O'Donnell, J. L., Khalilova, I., Turner, R., & Kettle, A. (2014). Oxidative stress from use of allopurinol: Is there a reason for patients with gout to take vitamin C? Arthritis & Rheumatology, 66(10, Suppl.), (pp. S532-S533). doi: 10.1002/art.38914
Kettle, A., Albrett, A., Forbes, L., Parker, H., Turner, R., Pattemore, P., & Winterbourn, C. (2014). Bacterial killing and oxidant production by neutrophils from patients with cystic fibrosis. Free Radical Biology & Medicine, 76(Suppl. 1), (pp. S163). doi: 10.1016/j.freeradbiomed.2014.10.047
Harper, J. L., McLaughlin, R. M., Grainger, R., He, S., Harrison, A. A., Martin, W.-J., Kettle, T., & Stamp, L. K. (2014). Soluble urate: An endogenous driver of immune moderation. Proceedings of the Medical Sciences Congress (MedSci). (pp. 13). Retrieved from http://www.physoc.org.nz/meetings/archive/medsci-2014-abstracts
Conference Contribution - Poster Presentation (not in published proceedings)
Forbes, L. V., Parker, H., Turner, R., Albrett, A., & Kettle, A. J. (2014, December). Myeloperoxidase and protein oxidation in the neutrophil phagosome. Poster session presented at the Society for Free Radical Research Australasia 22nd Annual Scientific Meeting, Melbourne, Australia.
Conference Contribution - Verbal presentation and other Conference outputs
Kettle, A., Albrett, A., Forbes, L., Parker, H., Turner, R., Pattemore, P., & Winterbourn, C. (2014, November). Bacterial killing and oxidant production by neutrophils from patients with cystic fibrosis. Verbal presentation at the Society for Free Radical Biology and Medicine (SFRBM) 21st Annual Meeting, Seattle, WA.
Kettle, T. (2014, December). Love at first sight: The joy of working with a beautiful green enzyme [Special Services Award Lecture]. Plenary presentation at the Society for Free Radical Research Australasia 22nd Annual Scientific Meeting, Melbourne, Australia.
2013
Chapter in Book - Other
Winterbourn, C., & Kettle, T. (2013). Centre for Free Radical Research. In P. Joyce, G. Nicholls, K. Thomas & T. Wilkinson (Eds.), The Christchurch experience: 40 years of research and teaching. (pp. 75-78). Christchurch, New Zealand: University of Otago.
Journal - Research Article
Forbes, L. V., Sjögren, T., Auchère, F., Jenkins, D. W., Thong, B., Laughton, D., … Turner, R., … Kettle, A. J. (2013). Potent reversible inhibition of myeloperoxidase by aromatic hydromates. Journal of Biological Chemistry, 288(51), 36636-36647. doi: 10.1074/jbc.M113.507756
Paumann-Page, M., Furtmüller, P. G., Hofbauer, S., Paton, L. N., Obinger, C., & Kettle, A. J. (2013). Inactivation of human myeloperoxidase by hydrogen peroxide. Archives of Biochemistry & Biophysics, 539(1), 51-62. doi: 10.1016/j.abb.2013.09.004
Chapman, A. L. P., Mocatta, T. J., Shiva, S., Seidel, A., Chen, B., Khalilova, I., Paumann-Page, M. E., Jameson, G. N. L., Winterbourn, C. C., & Kettle, A. J. (2013). Ceruloplasmin is an endogenous inhibitor of myeloperoxidase. Journal of Biological Chemistry, 288(9), 6465-6477. doi: 10.1074/jbc.M112.418970
Klebanoff, S. J., Kettle, A. J., Rosen, H., Winterbourn, C. C., & Nauseef, W. M. (2013). Myeloperoxidase: A front-line defender against phagocytosed microorganisms. Journal of Leukocyte Biology, 93(2), 185-198. doi: 10.1189/jlb.0712349
Winterbourn, C. C., & Kettle, A. J. (2013). Redox reactions and microbial killing in the neutrophil phagosome. Antioxidants & Redox Signaling, 18(6), 642-660. doi: 10.1089/ars.2012.4827
Conference Contribution - Published proceedings: Abstract
Jameson, G. N. L., Seidel, A., Parker, H., Turner, R., Dickerhof, N., Wilbanks, S. M., Kettle, A. J., Young, V. L., & Ward, V. K. (2013). Uric acid modulates the activity of lactoperoxidase. Proceedings of the New Zealand Institute of Chemistry (NZIC) Conference. Christchurch, New Zealand: NZIC. [Abstract]
Kettle, T., Turner, R., Gangell, C., Khalilova, I., Harwood, T., Chapman, A., Winterbourn, C., … on behalf of AREST CF. (2013). The battle between chlorine bleach and glutathione in the lungs of kids with cystic fibrosis. Proceedings of the George Abbott Symposium. Retrieved from http://www.otago.ac.nz/george-abbott
Turner, R., Wu, Y., Li, L., Tang, W., Hazen, S. L., & Kettle, A. (2013). Uric acid oxidation as a biomarker of cardiovascular disease. Free Radical Biology & Medicine, 65(Suppl. 2), (pp. S74). doi: 10.1016/j.freeradbiomed.2013.10.566
Magon, N. J., Turner, R., Dickerhof, N., Gearry, R., Hampton, M., Sly, P., & Kettle, A. (2013). Oxidation of methionine in calprotectin by neutrophils in the airways of children with cystic fibrosis. Free Radical Biology & Medicine, 65(Suppl. 2), (pp. S62-S63). doi: 10.1016/j.freeradbiomed.2013.10.535
Kettle, A., Turner, R., Gangell, C. L., Khalilova, I., Harwood, D. T., Chapman, A., Winterbourn, C. C., & Sly, P. (2013). Oxidation of glutathione by hypochlorous acid in the airways of children with cystic fibrosis. Free Radical Biology & Medicine, 65(Suppl. 2), (pp. S62). doi: 10.1016/j.freeradbiomed.2013.10.534
Forbes, L. V., Sjögren, T., Auchère, F., Thong, B., Eriksson, H., Unitt, J. F., & Kettle, A. (2013). Potent reversible inhibition of myeloperoxidase by aromatic hydroxamates. Free Radical Biology & Medicine, 65(Suppl. 2), (pp. S127). doi: 10.1016/j.freeradbiomed.2013.10.712
Dickerhof, N., Kettle, A. J., & Hampton, M. B. (2013). Covalent modification of the pro-inflammatory cytokine MIF by dietary and endogenous electrophiles. Free Radical Biology & Medicine, 65(Suppl. 2), (pp. S35-S36). doi: 10.1016/j.freeradbiomed.2013.10.470
Das, A., Nagy, P., Lecthe, T., Koppenol, W. H., Winterbourn, C. C., & Kettle, A. (2013). Detection of glutathione conjugated to oxidised tyrosine residues on proteins. Free Radical Biology & Medicine, 65(Suppl. 2), (pp. S55). doi: 10.1016/j.freeradbiomed.2013.10.520
Conference Contribution - Poster Presentation (not in published proceedings)
Seidel, A., Jameson, G., Turner, R., Kettle, A., & Wilbanks, S. (2013, July). Urate as a potential physiological substrate for lactoperoxidase. Poster session presented at the XVIth International Conference on Biological Inorganic Chemistry, Grenoble, France.
Seidel, A., Turner, R., Wilbanks, S. M., Kettle, A. J., & Jameson, G. N. L. (2013, September). Urate as potential physiological substrate for lactoperoxidase. Poster session presented at the Division of Health Sciences Research Forum: Foundations for Health: Otago Health Research, Christchurch, New Zealand.
Turner, R., Wu, Y., Li, L., Tang, W. H. W., Hazen, S. L., & Kettle, A. J. (2013, August). Uric Acid oxidation as a biomarker of cardiovascular disease. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Khalilova, I. S., Dickerhof, N., Mocatta, T., & Kettle, A. J. (2013, August). Pro-myeloperoxidase is present in circulation and a potential participant in cardiovascular disease. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Dickerhof, N., Kettle, A. J., & Hampton, M. B. (2013, August). Covalent modification of the pro-inflammatory cytokine MIF by dietary and endogenous electrophiles. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Spencer, E. S., Dale, E., Smith, R. A. J., Gamble, A. B., Tyndall, J. D. A., Rutledge, M. T., Wilbanks, S. M., Dickerhof, N., Kettle, A. J., & Hampton, M. B. (2013, August). Assessing inhibition of macrophage migration inhibitory factor by novel isothiocyanates. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Seidel, A., Turner, R., Wilbanks, S. M., Kettle, A. J., & Jameson, G. N. L. (2013, August). Urate as a potential physiological substrate for lactoperoxidase. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Magon, N. J., Gearry, R. B., Hampton, M. B., & Kettle, A. J. (2013, August). Oxidised calprotectin as a biomarker for inflammatory disease. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Das, A. B., Nagy, P., Lechte, T., Winterbourn, C. C., & Kettle, A. J. (2013, August). Detection of glutathione conjugated to oxidized tyrosine residues on protein. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Kettle, T. (2013, September). Oxidation of uric acid during inflammation and cardiovascular disease. Verbal presentation at the 8th International Human Peroxidase Meeting, Sydney, Australia.
Seidel, A., Parker, H., Turner, R., Dickerhof, N., Wilbanks, S. M., Kettle, A. J., & Jameson, G. N. L. (2013, September). Urate as a potential physiological substrate for lactoperoxidase. Verbal presentation at the 8th International Human Peroxidase Meeting, Sydney, Australia.
Forbes, L. V., Sjögren, T., Auchère, F., Jenkins, D. W., Thong, B., Laughton, D., … Kettle, A. J. (2013, August). Potent reversible inhibition of myeloperoxidase by aromatic hydroxamates. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Parker, H., Albrett, A. M., Kettle, A. J., & Winterbourn, C. C. (2013, August). Neutrophil extracellular traps: Friends or foe. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Kettle, A. J., Turner, R., Stamp, L., Wu, Y., Li, L., Tang, W. H. W., … Akerstrom, B. (2013, August). Oxidation of uric acid during inflammation and cardiovascular disease. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Kettle, T. (2013, September). The battle between chlorine bleach and gluthathione in the lungs of kids with cystic fibrosis. Verbal presentation at the Ozone Research Group Public Symposium, Dunedin, New Zealand.
Other Research Output
Kettle, T. (2013, March). Free radicals spark the fires of inflammation. University of Otago Christchurch Health Lecture Series. Christchurch, New Zealand. [Public Seminar].
2012
Journal - Research Article
Kato, Y., Peskin, A. V., Dickerhof, N., Harwood, D. T., & Kettle, A. J. (2012). Myeloperoxidase catalyzes the conjugation of serotonin to thiols via free radicals and tryptamine-4,5-dione. Chemical Research in Toxicology, 25(11), 2322-2332. doi: 10.1021/tx300218f
Hock, B. D., Taylor, K. G., Cross, N. B., Kettle, A. J., Hampton, M. B., & McKenzie, J. L. (2012). Effect of activated human polymorphonuclear leucocytes on T lymphocyte proliferation and viability. Immunology, 137(3), 249-258. doi: 10.1111/imm.12004
Stamp, L. K., Khalilova, I., Tarr, J. M., Senthilmohan, R., Turner, R., Haigh, R. C., … Kettle, A. J. (2012). Myeloperoxidase and oxidative stress in rheumatoid arthritis. Rheumatology, 51(10), 1796-1803. doi: 10.1093/rheumatology/kes193
Forbes, L. V., Furtmüller, P. G., Khalilova, I., Turner, R., Obinger, C., & Kettle, A. J. (2012). Isoniazid as a substrate and inhibitor of myeloperoxidase: Identification of amine adducts and the influence of superoxide dismutase on their formation. Biochemical Pharmacology, 84(7), 949-960. doi: 10.1016/j.bcp.2012.07.020
Parker, H., Dragunow, M., Hampton, M. B., Kettle, A. J., & Winterbourn, C. C. (2012). Requirements for NADPH oxidase and myeloperoxidase in neutrophil extracellular trap formation differ depending on the stimulus. Journal of Leukocyte Biology, 92(4), 841-849. doi: 10.1189/jlb.1211601
Parker, H., Albrett, A. M., Kettle, A. J., & Winterbourn, C. C. (2012). Myeloperoxidase associated with neutrophil extracellular traps is active and mediates bacterial killing in the presence of hydrogen peroxide. Journal of Leukocyte Biology, 91(3), 369-376. doi: 10.1189/jlb.0711387
Journal - Research Other
Turner, R., Stamp, L. K., & Kettle, A. J. (2012). Detection of allantoin in clinical samples using hydrophilic liquid chromatography with stable isotope dilution negative ion tandem mass spectrometry [Short communication]. Journal of Chromatography B, 891-892, 85-89. doi: 10.1016/j.jchromb.2012.02.009
Conference Contribution - Published proceedings: Abstract
Turner, R., Mocatta, T., McClean, D., Marshall, C. J., Cameron, V. A., & Kettle, A. J. (2012). Allantoin as a biomarker of severity of heart disease and its relationship with myeloperoxidase. Proceedings of the Oxygen Theme Meeting. (pp. 33). Dunedin, New Zealand: University of Otago. Retrieved from https://www.otago.ac.nz/research/otago051864.pdf
Khalilova, I. S., Dickerhof, N., Mocatta, T., & Kettle, A. J. (2012). Detection of pro-myeloperoxidase in circulation. Proceedings of the Oxygen Theme Meeting. (pp. 29). Dunedin, New Zealand: University of Otago. Retrieved from https://www.otago.ac.nz/research/otago051864.pdf
Parker, H., Albrett, A., Kettle, A., & Winterbourn, C. (2012). Complex roles of reactive oxygen species in the formation and antimicrobial action of neutrophil NETs. Proceedings of the Oxygen Theme Meeting. (pp. 28). Dunedin, New Zealand: University of Otago. Retrieved from https://www.otago.ac.nz/research/otago051864.pdf
Chapman, A., Turner, R., & Kettle, A. J. (2012). Seeking evidence for a halogenating intermediate of myeloperoxidase. Proceedings of the Oxygen Theme Meeting. (pp. 25). Dunedin, New Zealand: University of Otago. Retrieved from https://www.otago.ac.nz/research/otago051864.pdf
Albrett, A. M., Kettle, A. J., & Winterbourn, C. C. (2012). Modulation of HOCl production in neutrophil phagosomes. Proceedings of the Oxygen Theme Meeting. (pp. 24). Dunedin, New Zealand: University of Otago. Retrieved from https://www.otago.ac.nz/research/otago051864.pdf
Seidel, A., Turner, R., Wilbanks, S. M., Kettle, A. J., & Jameson, G. N. L. (2012). Urate oxidation by Lactoperoxidase. Proceedings of the Oxygen Theme Meeting. (pp. 9). Dunedin, New Zealand: University of Otago. Retrieved from https://www.otago.ac.nz/research/otago051864.pdf
Magon, N. J., Gearry, R. B., Hampton, M. B., & Kettle, A. J. (2012). Oxidised calprotectin as a biomarker for inflammatory disease. Proceedings of the Oxygen Theme Meeting. (pp. 8). Dunedin, New Zealand: University of Otago. Retrieved from https://www.otago.ac.nz/research/otago051864.pdf
Das, A. B., Nagy, P., Lechte, T., Kettle, A. J., & Winterbourn, C. C. (2012). Conjugation of glutathione to oxidised tyrosine residues on proteins. Proceedings of the Oxygen Theme Meeting. (pp. 7). Dunedin, New Zealand: University of Otago. Retrieved from https://www.otago.ac.nz/research/otago051864.pdf
Maghzal, G. J., Cergol, K., Suarna, C., Newington, D., Kettle, A. J., Payne, R. J., & Stocker, R. (2012). In vivo detection of myeloperoxidase activity by LC/MS/MS analysis of 2-chloro-ethidium, a novel product formed from the reaction of hydroethidine with hypochlorous acid and chloramines. Free Radical Biology & Medicine, 53(Suppl. 2), (pp. S24). doi: 10.1016/j.freeradbiomed.2012.10.059
Stamp, L. K., Khalilova, I., Zhang, M., Turner, R., & Kettle, A. (2012). Oxidation of urate to allantoin by myeloperoxidase in gout. Arthritis & Rheumatism, 64(10, Suppl.), (pp. S808). doi: 10.1002/art.37735
Turner, R., Mocatta, T., McClean, D., Marshall, C., & Kettle, A. (2012). Allantoin as a biomarker of severity of heart disease and its relationship with myeloperoxidase. Free Radical Biology & Medicine, 53(Suppl. 1), (pp. S135-S136). doi: 10.1016/j.freeradbiomed.2012.08.283
Parker, H., Albrett, A. M., Kettle, A. J., & Winterbourn, C. C. (2012). Complex roles of reactive oxygen species in the formation and anti-microbial action of neutrophil NETs. Free Radical Biology & Medicine, 53(Suppl. 1), (pp. S166). doi: 10.1016/j.freeradbiomed.2012.08.349
Maghzal, G. J., Cergol, K., Suarna, C., Newington, D., Kettle, A. J., Payne, R. J., … et al (2012). In vivo detection of myeloperoxidase activity by LC/MS analysis of 2-chloro-ethidium, a novel product formed from the reaction of hydroethidine with hypochlorous acid and chloramines. Free Radical Biology & Medicine, 53(Suppl. 1), (pp. S223-S224). doi: 10.1016/j.freeradbiomed.2012.08.469
Conference Contribution - Verbal presentation and other Conference outputs
Kettle, T. (2012, November-December). Ceruloplasmin is an endogenous inhibitor of myeloperoxidase. Verbal presentation at the Free Radical and Metal Biology Conference, Brisbane, Australia.
2011
Journal - Research Article
Tidén, A.-K., Sjögren, T., Svensson, M., Bernlind, A., Senthilmohan, R., Auchère, F., … Forbes, L. V., Magon, N. J., Paton, L. N., Jameson, G. N. L., … Kettle, A. J. (2011). 2-Thioxanthines are mechanism-based inactivators of myeloperoxidase that block oxidative stress during inflammation. Journal of Biological Chemistry, 286(43), 37578-37589. doi: 10.1074/jbc.M111.266981
Moya-Olano, L., Milne, H. M., Robinson, J. M., Hill, J. V., Frampton, C. M., Abbott, H. F., Turner, R., Kettle, A. J., & Endre, Z. H. (2011). Trientine and renin-angiotensin system blockade ameliorate progression of glomerular morphology in hypertensive experimental diabetic nephropathy. Pathology International, 61(11), 652-661. doi: 10.1111/j.1440-1827.2011.02721.x
Kettle, A. J., Maroz, A., Woodroffe, G., Winterbourn, C. C., & Anderson, R. F. (2011). Spectral and kinetic evidence for reaction of superoxide with compound I of myeloperoxidase. Free Radical Biology & Medicine, 51(12), 2190-2194. doi: 10.1016/j.freeradbiomed.2011.09.019
Meotti, F. C., Jameson, G. N. L., Turner, R., Harwood, D. T., Stockwell, S., Rees, M., … Kettle, A. J. (2011). Urate as a physiological substrate for myeloperoxidase: Implications for hyperuricemia and inflammation. Journal of Biological Chemistry, 286(15), 12901-12911. doi: 10.1074/jbc.M110.172460
Conference Contribution - Published proceedings: Abstract
Marshall, C. J., McKenzie, J. L., Moccata, T., Nallaratnam, M., Blake, J., Frampton, C., Richards, M., Kettle, A. J., & McClean, D. R. (2011). Neutrophil activation at the culprit lesion in acute ST-segment elevation myocardial infarction with multiple complex coronary plaques. Heart, 97(Suppl. 1), (pp. A11-A12). doi: 10.1136/heartjnl-2011-300198.13
Conference Contribution - Poster Presentation (not in published proceedings)
Kato, Y., Miura, Y., Naito, M., Kitamoto, N., & Kettle, A. J. (2011, January). Immunohistochemical detection of serotonin oxidation products in human atherosclerotic lesion. Poster session presented at the International Symposium on Free Radical Research: Contribution to Medicine, Kyoto, Japan.
Conference Contribution - Verbal presentation and other Conference outputs
Kettle, A. J., Meotti, F., Turner, R., Mocatta, T., Jameson, G., Marshall, C., … Stamp, L. (2011, August). Interactions of myeloperoxidase and urate during inflammation. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Kettle, T. (2011, May). Myeloperoxidase, urate and inflammation. Verbal presentation at the 7th International Human Peroxidase Meeting, Brussels, Belgium.
2010
Journal - Research Article
Thomson, E., Brennan, S., Senthilmohan, R., Gangell, C. L., Chapman, A. L., Sly, P., & Kettle, A. J. (2010). Identifying peroxidases and their oxidants in the early pathology of cystic fibrosis. Free Radical Biology & Medicine, 49(9), 1354-1360. doi: 10.1016/j.freeradbiomed.2010.07.010
Marshall, C. J., Nallaratnam, M., Mocatta, T., Smyth, D., Richards, M., Elliott, J. M., Blake, J., Winterbourn, C. C., Kettle, A. J., & McClean, D. R. (2010). Factors influencing local and systemic levels of plasma myeloperoxidase in ST-segment elevation acute myocardial infarction. American Journal of Cardiology, 106(3), 316-322. doi: 10.1016/j.amjcard.2010.03.028
Nagy, P., Kettle, A. J., & Winterbourn, C. C. (2010). Neutrophil-mediated oxidation of enkephalins via myeloperoxidase-dependent addition of superoxide. Free Radical Biology & Medicine, 49, 792-799. doi: 10.1016/j.freeradbiomed.2010.05.033
Das, A. B., Nagy, P., Abbott, H. F., Winterbourn, C. C., & Kettle, A. J. (2010). Reactions of superoxide with the myoglobin tyrosyl radical. Free Radical Biology & Medicine, 48, 1540-1547. doi: 10.1016/j.freeradbiomed.2010.02.039
Koelsch, M., Mallak, R., Graham, G. G., Kajer, T., Milligan, M. K., Nguyen, L. Q., … Kettle, A. J., … Davies, M. J. (2010). Acetaminophen (paracetamol) inhibits myeloperoxidase-catalyzed oxidant production and biological damage at therapeutically achievable concentrations. Biochemical Pharmacology, 79, 1156-1164. doi: 10.1016/j.bcp.2009.11.024
Ximenes, V. F., Maghzal, G. J., Turner, R., Kato, Y., Winterbourn, C. C., & Kettle, A. J. (2010). Serotonin as a physiological substrate for myeloperoxidase and its superoxide-dependent oxidation to cytotoxic tryptamine-4,5-dione. Biochemical Journal, 425(1), 285-293. doi: 10.1042/BJ20090776
Conference Contribution - Published proceedings: Abstract
Stamp, L. K., Khalilova, I., & Kettle, T. (2010). Acute gout results in increased plasma myeloperoxidase: A potential mechanism for increased cardiovascular risk? Arthritis & Rheumatism, 62(Suppl. 10). doi: 10.1002/art.30166
Magon, N. J., Gearry, R. B., Hampton, M. B., & Kettle, A. J. (2010). Oxidised calprotectin as a biomarker for inflammatory disease. Free Radical Biology and Medicine. 49(Suppl. 1), (pp. S169). doi: 10.1016/j.freeradbiomed.2010.10.479
Conference Contribution - Poster Presentation (not in published proceedings)
Forbes, L. V., & Kettle, A. J. (2010, November-December). Hydrazides as inhibitors of myeloperoxidase. Poster session presented at the Society for Free Radical Research (SFRR) Australasia 19th Annual Conference, Akaroa, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Kettle, T. (2010, November-December). A radical history of oxygen. Verbal presentation at the Society for Free Radical Research (SFRR) Australasia 19th Annual Conference, Akaroa, New Zealand.
Parker, H. A., Kettle, A. J., Hampton, M. B., & Winterbourn, C. C. (2010, November-December). Oxidants, MPO and calcium in neutrophil extracellular trap formation. Verbal presentation at the Society for Free Radical Research (SFRR) Australasia 19th Annual Conference, Akaroa, New Zealand.
Stamp, L., Khalilova, I. S., Tarr, J. M., Senthilmohan, R., Haigh, R. C., Whiteman, M., … Kettle, A. J. (2010, November-December). Myeloperoxidase and oxidative stress in rheumatoid arthritis. Verbal presentation at the Society for Free Radical Research (SFRR) Australasia 19th Annual Conference, Akaroa, New Zealand.
Kettle, A. J., Turner, R., Gangell, C. L., Khalilova, I. S., Harwood, D. T., Chapman, A. L., Winterbourn, C. C., … on behalf of AREST CF. (2010, November-December). Oxidation of glutathione in the airways of children with cystic fibrosis. Verbal presentation at the Society for Free Radical Research (SFRR) Australasia 19th Annual Conference, Akaroa, New Zealand.
Turner, R., Khalilova, I., Stamp, L., Meotti, F. C., Thomas, S., Rees, M. D., & Kettle, A. J. (2010, November-December). Interactions between urate and myeloperoxidase in gout. Verbal presentation at the Society for Free Radical Research (SFRR) Australasia 19th Annual Conference, Akaroa, New Zealand.
Chapman, A. L. P., Chen, B., Mocatta, T. J., Winterbourn, C. C., & Kettle, A. J. (2010, November-December). Studying the inhibition of myeloperoxidase by ceruloplasmin. Verbal presentation at the Society for Free Radical Research (SFRR) Australasia 19th Annual Conference, Akaroa, New Zealand.
Kettle, A., Meotti, F. C., Jameson, G. N. L., Stamp, L., Turner, R., Harwood, T., Stockwell, S. C., … Thomas, S. R. (2010, August). Linking myeloperoxidase and uric acid to cardiovascular disease. Verbal presentation at the New Zealand Rheumatology Association Annual Scientific Meeting, Christchurch, New Zealand.
Kettle, T. (2010, September). A radical look at health and disease. Verbal presentation at the Fourth Annual Division of Health Sciences Research Forum, Dunedin, New Zealand.
2009
Journal - Research Article
van Dalen, C. J., Aldridge, R. E., Chan, T., Senthilmohan, R., Hancox, R. J., Cowan, J. O., Taylor, D. R., Town, G. I., & Kettle, A. J. (2009). Bromotyrosines in sputum proteins and treatment effects of terbutaline and budesonide in asthma. Annals of Allergy, Asthma & Immunology, 103(4), 348-353.
Peskin, A. V., Turner, R., Maghzal, G. J., Winterbourn, C. C., & Kettle, A. J. (2009). Oxidation of methionine to dehydromethionine by reactive halogen species generated by neutrophils. Biochemistry, 48(42), 10175-10182. doi: 10.1021/bi901266w
Chapman, A. L. P., Skaff, O., Senthilmohan, R., Kettle, A. J., & Davies, M. J. (2009). Hypobromous acid and bromamine production by neutrophils and modulation by superoxide. Biochemical Journal, 417(3), 773-781. doi: 10.1042/BJ20071563
Nagy, P., Kettle, A. J., & Winterbourn, C. C. (2009). Superoxide-mediated formation of tyrosine hydroperoxides and methionine sulfoxide in peptides through radical addition and intramolecular oxygen transfer. Journal of Biological Chemistry, 284(22), 14723-14733. doi: 10.1074/jbc.M809396200
Harwood, D. T., Kettle, A. J., Brennan, S., & Winterbourn, C. C. (2009). Simultaneous determination of reduced glutathione, glutathione disulphide and glutathione sulphonamide in cells and physiological fluids by isotope dilution liquid chromatography-tandem mass spectrometry. Journal of Chromatography B, 877, 3393-3399. doi: 10.1016/j.jchromb.2009.04.018
Conference Contribution - Published proceedings: Abstract
Thai, T., Rees, M., Dang, L., Harwood, D. T., Winterbourn, C. C., Kettle, A. J., Maghzal, G., … Thomas, S. R. (2009). Myeloperoxidase and endothelial dysfunction. Journal of Vascular Research, 46(Suppl. 2), (pp. 10). doi: 10.1159/000230992
Tiden, A.-K., Sjögren, T., Senthilmohan, R., Auchere, F., Eriksson, H., & Kettle, A. J. (2009). Development of inhibitors for myeloperoxidase (AVZ115X71). Proceedings of the ComBio2009 Conference. [CD-ROM] [Abstract]
Das, A. B., Nagy, P., Abbott, H., Winterbourn, C. C., & Kettle, A. J. (2009). Reactions of superoxide with the myoglobin tyrosyl radical. Free Radical Biology and Medicine. 47(Suppl. 1), (pp. S74). [Abstract]
Marshall, C. J., Nallaratnam, M., Mocatta, T., Smyth, D., Richards, A. M., Elliott, J. M., Blake, J., Winterbourn, C., Kettle, A. J., & McClean, D. R. (2009). Plasma myeloperoxidase at the culprit coronary lesion in acute myocardial infarction. Heart, Lung & Circulation, 18(Suppl. 2), (pp. S22-S23). doi: 10.1016/j.hlc.2009.04.052
Marshall, C. J., Nallaratnam, M., Mocatta, T., Smyth, D., Richards, M., Elliott, J. M., Blake, J., Winterbourn, C., Kettle, A. J., & McClean, D. R. (2009). Plasma myeloperoxidase at the culprit coronary lesion in acute myocardial infarction. Heart, Lung & Circulation, 18(Suppl. 3), (pp. S119-S120). doi: 10.1016/j.hlc.2009.05.270
Marshall, C. J., Mocatta, T., McKenzie, J., Kettle, A., Blake, J., Elliott, J., Smyth, D., Richards, M., & McClean, D. R. (2009). Acute systemic and local neutrophil and monocyte degranulation prior to primary percutaneous coronary intervention in ST elevation myocardial infarction. JACC, 53(10, Suppl. 1), (pp. A307-A308). [Abstract]
Conference Contribution - Poster Presentation (not in published proceedings)
Kettle, T. (2009, December). Urate is a physiological substrate for myeloperoxidase that is converted to a reactive hydroperoxide in the presence of superoxide. Poster session presented at the 5th Joint Meeting of The Societies for Free Radical Research Australasia and Japan & Mutagenesis and Experimental Pathology Society of Australia, Sydney, Australia.
Das, A. B., Nagy, P., Abbott, H., Winterbourn, C. C., & Kettle, A. J. (2009, September). Superoxide mediated protein oxidation: A potential mechanism for superoxide toxicity. Poster session presented at the Third Annual Division of Health Sciences Research Forum, Wellington, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Kettle, A. (2009, December). Development of inhibitors for myeloperoxidase. Verbal presentation at the 5th Joint Meeting of The Societies for Free Radical Research Australasia and Japan & Mutagenesis and Experimental Pathology Society of Australia, Sydney, Australia.
van Dalen, C., Senthilmohan, R., Kettle, A., Harding, E., Cheng, S., Pearce, N., … Douwes, J. (2009, June). Sputum granulocyte activation in adolescents with asthma. Verbal presentation at the New Zealand Australasian Society for Immunology (NZ ASI) Branch Meeting, Wellington, New Zealand.
2008
Journal - Research Article
Coker, M. S. A., Hu, W.-P., Senthilmohan, S. T., & Kettle, A. J. (2008). Pathways for the decay of organic dichloramines and liberation of antimicrobial chloramine gases. Chemical Research in Toxicology, 21(12), 2334-2343. doi: 10.1021/tx800232v
Harwood, D. T., Nimmo, S. L., Kettle, A. J., Winterbourn, C. C., & Ashby, M. T. (2008). Molecular structure and dynamic properties of a sulfonamide derivative of glutathione that is produced under conditions of oxidative stress by hypochlorous acid. Chemical Research in Toxicology, 21(5), 1011-1016.
Meotti, F. C., Senthilmohan, R., Harwood, D. T., Missau, F. C., Pizzolatti, M. G., & Kettle, A. J. (2008). Myricitrin as a substrate and inhibitor of myeloperoxidase: Implications for the pharmacological effects of flavonoids. Free Radical Biology & Medicine, 44(1), 109-120. doi: 10.1016/j.freeradbiomed.2007.09.017
Senthilmohan, S. T., Kettle, A. J., McEwan, M. J., Dummer, J., Edwards, S. J., Wilson, P. F., & Epton, M. J. (2008). Detection of monobromamine, monochloramine and dichloramine using selected ion flow tube mass spectrometry and their relevance as breath markers. Rapid Communications in Mass Spectrometry, 22(5), 677-681. doi: 10.1002/rcm.3418
Conference Contribution - Published proceedings: Abstract
Marshall, C., Mocatta, T., McKenzie, J., Kettle, A. J., Blake, J., Elliott, J., Smyth, D., Richards, M., & McClean, D. R. (2008). Increased neutrophil and monocyte degranulation with release of intracellular leucocyte elastase and myeloperoxidase in acute ST elevation myocardial infarction. Heart, Lung & Circulation, 17S, (pp. S2). doi: 10.1016/j.hlc.2008.03.003
Marshall, C., Mocatta, T., McKenzie, J., Kettle, A., Blake, J., Elliott, J., Smyth, D., Richards, M., & McClean, D. (2008). Increased systemic and local neutrophil and monocyte degranulation in patients undergoing primary percutaneous coronary intervention for acute ST elevation myocardial infarction. Heart, Lung & Circulation, 17S, (pp. S106). doi: 10.1016/j.hlc.2008.05.255
Nallaratnam, M., Mocatta, T., Marshall, C., Smyth, D., Winterbourn, C., Elliott, J., Richards, M., Kettle, A. J., & McClean, D. R. (2008). Local leukocyte elastase release at site of occlusive plaque rupture predicts downstream microvascular reperfusion injury and impaired left ventricular function in ST elevation myocardial infarction. JACC, 1(2 (Suppl. B)), (pp. B64). [Abstract]
Conference Contribution - Verbal presentation and other Conference outputs
Kettle, T. (2008, November). Liberation of chloramine gases during bacterial killing by neutrophils. Verbal presentation at the Society for Free Radical Research Australasia Conference, Melbourne, Australia.
2007
Journal - Research Article
Åkerström, B., Maghzal, G. J., Winterbourn, C. C., & Kettle, A. J. (2007). The lipocalin α1-microglobulin has radical scavenging activity. Journal of Biological Chemistry, 282(43), 31493-31503.
Kettle, A. J., Anderson, R. F., Hampton, M. B., & Winterbourn, C. C. (2007). Reactions of superoxide with myeloperoxidase. Biochemistry, 46, 4888-4897.
Conference Contribution - Published proceedings: Abstract
Rodger, E. J., Revell, A. F., Jones, G. T., Kleffmann, T., Kettle, A. J., & McCormick, S. P. A. (2007). Proteomic analysis of livers from mice with an atherogenic lipoprotein profile. Journal of Clinical Lipidology, 1(5), (pp. 417). doi: 10.1016/j.jacl.2007.08.016
Nallaratnam, M., Mocatta, T., Kettle, A. J., Smyth, D., Winterbourn, C., Elliott, J., Richards, M., & McClean, D. (2007). Plasma myeloperoxidase levels are highest in the Infarct-Related Artery (IRA) in patients with ST Elevation MI. Heart, Lung & Circulation, 16(Suppl. 2), (pp. S25). doi: 10.1016/j.hlc.2007.06.065
Nallaratnam, M., Mocatta, T., Kettle, A. J., Smyth, D., Winterbourn, C., Elliott, J., Richards, M., & McClean, D. (2007). Heparin, but not bilvalirudin, liberates endothelial myeloperoxidase in patients with ST Elevation Myocardial Infarction (STEMI). Heart, Lung & Circulation, 16(Suppl. 2), (pp. S24-S25). doi: 10.1016/j.hlc.2007.06.064
2006
Journal - Research Article
Winterbourn, C. C., Hampton, M. B., Livesey, J. H., & Kettle, A. J. (2006). Modeling the reactions of superoxide and myeloperoxidase in the neutrophil phagosome: Implications for microbial killing. Journal of Biological Chemistry, 281(52), 39860-39869.
Brooks, W. M., Lash, H., Kettle, A. J., & Epton, M. J. (2006). Optimising hydrogen peroxide measurement in exhaled breath condensate. Redox Report, 11(2), 78-84.
Harwood, D. T., Kettle, A. J., & Winterbourn, C. C. (2006). Production of glutathione sulfonamide and dehydroglutathione from GSH by myeloperoxidase-derived oxidants and detection using a novel LC-MS/MS method. Biochemical Journal, 399, 161-168.
Senthilmohan, R., & Kettle, A. J. (2006). Bromination and chlorination reactions of myeloperoxidase at physiological concentrations of bromide and chloride. Archives of Biochemistry & Biophysics, 445, 235-244.
van Dalen, C. J., Winterbourn, C. C., & Kettle, A. J. (2006). Mechanism of nitrite oxidation by eosinophil peroxidase: Implications for oxidant production and nitration by eosinophils. Biochemical Journal, 394, 707-713.
2005
Journal - Research Article
Ximenes, V. F., Silva, S., Rodrigues, M. R., Catalani, L. H., Maghzal, G. J., Kettle, A. J., & Campa, A. (2005). Superoxide-dependent oxidation of melatonin by myeloperoxidase. Journal of Biological Chemistry, 280(46), 38160-38169.
Kettle, A. J., & Winterbourn, C. C. (2005). Do neutrophils produce ozone? An appraisal of current evidence. BioFactors, 24, 41-45.
Dypbukt, J. M., Bishop, C., Brooks, W. M., Thong, B., Eriksson, H., & Kettle, A. J. (2005). A sensitive and selective assay for chloramine production by myeloperoxidase. Free Radical Biology & Medicine, 39, 1468-1477.
2004
Journal - Research Article
Kettle, A. J., Chan, T., Osberg, I., Senthilmohan, R., Chapman, A. L. P., Mocatta, T. J., & Wagener, J. S. (2004). Myeloperoxidase and protein oxidation in the airways of young children with cystic fibrosis. American Journal of Respiratory & Critical Care Medicine, 170, 1317-1323.
Kettle, A. J., Clark, B. M., & Winterbourn, C. C. (2004). Superoxide converts indigo carmine to isatin sulfonic acid. Journal of Biological Chemistry, 279(18), 18521-18525.
Winterbourn, C. C., & Kettle, A. J. (2004). Reactions of superoxide with myeloperoxidase and its products. Japanese Journal of Infectious Diseases, 57, S31-S33.
Conference Contribution - Verbal presentation and other Conference outputs
Senthilmohan, R., & Kettle, A. J. (2004, December). Comparative reactivities of hypochlorous acid and hypobromous acid with human serum albumin. Verbal presentation at the 13th Annual Conference of the Society for Free Radical Research (Australasian): Oxidants and Antioxidants in Chemistry and Biology. Christchurch.
2003
Journal - Research Article
Winterbourn, C. C., & Kettle, A. J. (2003). Radical-radical reactions of superoxide: A potential route to toxicity. Biochemical & Biophysical Research Communications, 305, 729-736.
Buss, I. H., Senthilmohan, R., Darlow, B. A., Mogridge, N., Kettle, A. J., & Winterbourn, C. C. (2003). 3-Chlorotyrosine as a marker of protein damage by myeloperoxidase in tracheal aspirates from preterm infants: Association with adverse respiratory outcome. Pediatric Research, 53(3), 455-462.
Chapman, A. L. P., Winterbourn, C. C., Brennan, S., Jordan, T. W., & Kettle, A. J. (2003). Characterization of non-covalent oligomers of proteins treated with hypochlorous acid. Biochemical Journal, 375, 33-40.
Conference Contribution - Published proceedings: Abstract
Buss, I. H., Senthilmohan, R., Darlow, B. A., Mogridge, N., Kettle, A. J., & Winterbourn, C. C. (2003). Chlorotyrosine as a marker of protein damage by myeloperoxidase in tracheal aspirates from preterm infants - association with adverse respiratory outcome. Proceedings of the 7th Annual Congress of the Perinatal Society of Australia and New Zealand. [Abstract]
2002
Journal - Research Article
Aldridge, R. E., Chan, T. P., van Dalen, C. J., Senthilmohan, R., Winn, M., Venge, P., Town, G. I., & Kettle, A. J. (2002). Eosinophil peroxidase produces hypobromous acid in the airways of stable asthmatics. Free Radical Biology & Medicine, 33(6), 847-856.
Upston, J., Niu, X., Brown, A., Mashima, R., Wang, H., Senthilmohan, R., Kettle, A. J., … Stocker, R. (2002). Disease stage-dependent accumulation of lipid and protein oxidation products in human atherosclerosis. American Journal of Pathology, 160(2), 701-710.
Chapman, A. L. P., Hampton, M. B., Senthilmohan, R., Winterbourn, C. C., & Kettle, A. J. (2002). Chlorination of bacterial and neutrophil proteins during phagocytosis and killing of Staphylococcus aureus. Journal of Biological Chemistry, 277(12), 9757-9762.
Conference Contribution - Published proceedings: Full paper
Buss, I. H., Senthilmohan, R., Darlow, B. A., Mogridge, N., Cheah, F. C., Kettle, A. J., & Winterbourn, C. C. (2002). 3-Chlorotyrosine in tracheal aspirate samples from very-low-birthweight infants: Associations with myeloperoxidase, protein carbonyls and clinical outcome. Proceedings of the 4th Annual Congress of the Perinatal Society of Australia and New Zealand. Christchurch, New Zealand. [Full Paper]
2001
Journal - Research Article
van Dalen, C. J., & Kettle, A. J. (2001). Substrates and products of eosinophil peroxidase. Biochemical Journal, 358, 233-239.
Kettle, A. J., & Winterbourn, C. C. (2001). A kinetic analysis of the catalase activity of myeloperoxidase. Biochemistry, 40, 10204-10212.
Conference Contribution - Published proceedings: Abstract
Senthilmohan, R., Mocatta, T., Buss, H., Darlow, B. A., Wagner, J., Kettle, A. J., & Winterbourn, C. C. (2001). Oxidative modification of protein in cystic fibrosis and in chronic lung disease of preterm infants. The 8th Annual Meeting of the Oxygen Society. 31(269 (Suppl 1)), (pp. S89). Free Radical Biology and Medicine. [Abstract]
2000
Chapter in Book - Research
Winterbourn, C. C., van Dalen, C. J., Hampton, M. B., & Kettle, A. J. (2000). Reactions of myeloperoxidase and production of hypochlorous acid in neutrophil phagosomes. In P. E. Petrides & W. M. Nauseef (Eds.), The Peroxidase Multigene Family of Enzymes. (pp. 58-67). Berlin: Springer.
Journal - Research Article
Chapman, A. L. P., Senthilmohan, R., Winterbourn, C. C., & Kettle, A. J. (2000). Comparison of mono- and dichlorinated tyrosines with carbonyls for detection of hypochlorous acid modified proteins. Archives of Biochemistry & Biophysics, 377(1), 95-100.
Burner, U., Furtmuller, P. G., Kettle, A. J., Koppenol, W. H., & Obinger, C. (2000). Mechanism of reaction of myeloperoxidase with nitrite. Journal of Biological Chemistry, 275, 20597-20601.
Kettle, A. J., & Candaeis, L. P. (2000). Oxidation of tryptophan by redox intermediates of myeloperoxidase and inhibition of hypochlorous acid production. Redox Report, 5, 179-184.
van Dalen, C. J., Winterbourn, C. C., Senthilmohan, R., & Kettle, A. J. (2000). Nitrite as a substrate and inhibitor of myeloperoxidase: Implications for nitration and hypochlorous acid production at sites of inflammation. Journal of Biological Chemistry, 275, 11638-11644.
Vile, G., Rothwell, L. A., & Kettle, A. J. (2000). Initiation of rapid, p53-dependent growth arrest in cultured human skin fibroblasts by reactive chlorine species. Archives of Biochemistry & Biophysics, 377, 122-128.
Winterbourn, C. C., & Kettle, A. J. (2000). Biomarkers of myeloperoxidase-derived hypochlorous acid. Free Radical Biology & Medicine, 29, 403-409.
Journal - Research Other
Kettle, A. J., & Obinger, C. (2000). Mammalian peroxidases brought into focus [Editorial]. Redox Report, 5(4), 167-168.
Winterbourn, C. C., Vissers, M. C., & Kettle, A. J. (2000). Myeloperoxidase. Current Opinion in Hematology, 7, 53-58. [Review].
1999
Journal - Research Article
Burner, U., Obinger, C., Paumann, M., Furtmuller, P. G., & Kettle, A. J. (1999). Transient and steady-state kinetics of the oxidation of substituted benzoic acid hydrazides by myeloperoxidase. Journal of Biological Chemistry, 274, 9494-9592. doi: 10.1074/jbc.274.14.9494
Kettle, A. J. (1999). Detection of 3-chlorotyrosine in proteins exposed to neutrophil oxidants. Methods in Enzymology, 300, 111-120.
Conference Contribution - Verbal presentation and other Conference outputs
Senthilmohan, R., Chapman, A. L. P., Winterbourn, C. C., & Kettle, A. J. (1999, December). A gas chromatographic-mass spectral assay for the simultaneous quantification of modified Tyrosyl residues and Hydroxylated phenylalanine residues in biological samples. Verbal presentation at the Oxidative Pathways in Health and Disease Conference, Sydney, Australia.
1998
Journal - Research Article
Graham, G. G., & Kettle, A. J. (1998). The activation of gold complexes by cyanide produced by polymorphonuclear leukocytes. III. The formation of aurocyanide by myeloperoxidase. Biochemical Pharmacology, 56, 307-312.
Vile, G., Rothwell, L. A., & Kettle, A. J. (1998). Hypoclhlorus acid activates the tumor suppressor protein p53 in cultured human skin fibroblasts. Archives of Biochemistry & Biophysics, 359, 51-56.
Hampton, M. B., Kettle, A. J., & Winterbourn, C. C. (1998). Inside the neutrophil phagosome: oxidants, myeloperoxidase and bacterial killing. Blood, 92, 3007-3017.
1997
Chapter in Book - Research
McPherson, K. G., Kettle, A. J., & Winterbourn, C. C. (1997). Mechanism of activation of NFKB by hydrogen peroxide in Jurkat JR cells. In L. Montagnier, R. Olivier & C. Pasquier (Eds.), Oxidative Stress and Redox Regulation: Cellular Signalling, Aids, Cancer and Other Diseases. (pp. 83-87). New York: Marcel Dekker.
Journal - Research Article
Winterbourn, C. C., Pichorner, H., & Kettle, A. J. (1997). Myeloperoxidase-dependent generation of a tyrosine peroxide by neutrophils. Archives of Biochemistry & Biophysics, 338(1), 15-21.
Van Dalen, C. J., Whitehead, M. W., Winterbourn, C. C., & Kettle, A. J. (1997). Thiocyanate and chloride as competing substrates for myeloperoxidase. Biochemical Journal, 327(2), 487-492.
Panousis, C., Kettle, A. J., & Phillips, D. R. (1997). Neutrophil-mediated activation of mitoxantrone to metabolites which form adducts with DNA. Cancer Letters, 113(1/2), 173-178.
Kettle, A. J., Gedye, C. A., & Winterbourn, C. C. (1997). Mechanism of inactivation of myeloperoxidase by 4-aminobenzoic acid hydrazide. Biochemical Journal, 321(2), 503-508.
Journal - Research Other
Kettle, A. J., & Winterbourn, C. C. (1997). Myeloperoxidase: A key regulator of neutrophil oxidant production. Redox Report, 3(1), 3-15. doi: 10.1080/13510002.1997.11747085
Journal - Professional & Other Non-Research Articles
Kettle, A. J., Van Dalen, C. J., & Winterbourn, C. C. (1997). Peroxynitrite and myeloperoxidase leave the same foorprint in protein nitration. Redox Report, 3, 257-258.
1996
Chapter in Book - Research
Kettle, A. J., & Winterbourn, C. C. (1996). Reaction mechanisms of myeloperoxidase. In C. Obinger, U. Burner, R. Ebermann, C. Penel & H. Greppin (Eds.), Plant Peroxidases: Biochemistry and Physiology. (pp. 134-139). Geneva: University of Geneva.
Journal - Research Article
Hampton, M. B., Kettle, A. J., & Winterbourn, C. C. (1996). Involvement of superoxide and myeloperoxidase in oxygen-dependent killing of Straphuylococcus aureus by neutrophils. Infection & Immunity, 64(9), 3512-3517.
Kettle, A. J. (1996). Detection of chlorotyrosine in albumin exposed to stimulated human neutrophils. FEBS Letters, 379(1), 103-106.
Journal - Professional & Other Non-Research Articles
Kettle, A. J. (1996). Crisis for biomedical research in New Zealand [Letter]. Lancet, 347(8994), 124. doi: 10.1016/S0140-6736(96)90251-2
1994
Journal - Research Article
Kettle, A. J., Carr, A. C., & Winterbourn, C. C. (1994). Assays using horseradish peroxidase and phenolic substrates require superoxide dismutase for accurate determination of hydrogen peroxide production by neutrophils. Free Radical Biology & Medicine, 17(2), 161-164.