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Dr Rachel Purcell

Rachel PurcellResearch Fellow

BSc(Hons)(Cork) MSc(Hons)(PIC) PhD(Otago)

Email rachel.purcell@otago.ac.nz

Rachel is a Research Fellow with the Department of Surgery. She has a background in molecular biology and cancer genetics.

Her research is centred on the molecular mechanisms of pathogenic bacteria in colorectal carcinogenesis.

Rachel's current research projects include investigating the effect of the gut microbiome on radiotherapy response in rectal cancer, microbiome-based markers of diverticular disease and molecular classification of colorectal cancer..

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Publications

Purcell, R. V., Kaakoush, N. O., Mitchell, H. M., Pearson, J. F., & Keenan, J. I. (2018). Gastrointestinal pathobionts in pediatric Crohn's disease patients. International Journal of Microbiology, 2018, 9203908. doi: 10.1155/2018/9203908

Purcell, R. V., Visnovska, M., Biggs, P. J., Schmeier, S., & Frizelle, F. A. (2017). Distinct gut microbiome patterns associate with consensus molecular subtypes of colorectal cancer. Scientific Reports, 7, 11590. doi: 10.1038/s41598-017-11237-6

Purcell, R. V., Pearson, J., Aitchison, A., Dixon, L., Frizelle, F. A., & Keenan, J. I. (2017). Colonization with enterotoxigenic Bacteroides fragilis is associated with early-stage colorectal neoplasia. PLoS ONE, 12(2), e0171602. doi: 10.1371/journal.pone.0171602

Purcell, R., Visnovska, M., Biggs, P., Schmeier, S., & Frizelle, F. (2017). Consensus molecular classification of colorectal cancer and association with the colonic microbiome. Proceedings of the American Society of Colon and Rectal Surgeons (ASCRS) Annual Scientific & Tripartite Meeting. (pp. 44-45). Retrieved from http://fascrs.org

Purcell, R. (2017, October). Distinct microbiome patterns associate with colorectal cancer molecular subtyptes. Verbal presentation at the New Zealand Society for Oncology (NZSO) Conference, Auckland, New Zealand.

Journal - Research Article

Purcell, R. V., Kaakoush, N. O., Mitchell, H. M., Pearson, J. F., & Keenan, J. I. (2018). Gastrointestinal pathobionts in pediatric Crohn's disease patients. International Journal of Microbiology, 2018, 9203908. doi: 10.1155/2018/9203908

Purcell, R. V., Visnovska, M., Biggs, P. J., Schmeier, S., & Frizelle, F. A. (2017). Distinct gut microbiome patterns associate with consensus molecular subtypes of colorectal cancer. Scientific Reports, 7, 11590. doi: 10.1038/s41598-017-11237-6

Purcell, R. V., Pearson, J., Aitchison, A., Dixon, L., Frizelle, F. A., & Keenan, J. I. (2017). Colonization with enterotoxigenic Bacteroides fragilis is associated with early-stage colorectal neoplasia. PLoS ONE, 12(2), e0171602. doi: 10.1371/journal.pone.0171602

Purcell, R. V., Pearson, J., Frizelle, F. A., & Keenan, J. I. (2016). Comparison of standard, quantitative and digital PCR in the detection of enterotoxigenic Bacteroides fragilis. Scientific Reports, 6, 34554. doi: 10.1038/srep34554

Keenan, J. I., Aitchison, A., Purcell, R. V., Greenlees, R., Pearson, J. F., & Frizelle, F. A. (2016). Screening for enterotoxigenic Bacteroides fragilis in stool samples. Anaerobe, 40, 50-53. doi: 10.1016/j.anaerobe.2016.05.004

Chatterjee, A., Leichter, A. L., Fan, V., Tsai, P., Purcell, R. V., Sullivan, M. J., & Eccles, M. R. (2015). A cross comparison of technologies for the detection of microRNAs in clinical FFPE samples of hepatoblastoma patients. Scientific Reports, 5, 10438. doi: 10.1038/srep10438

Leichter, A. L., Purcell, R. V., Sullivan, M. J., Eccles, M. R., & Chatterjee, A. (2015). Multi-platform microRNA profiling of hepatoblastoma patients using formalin fixed paraffin embedded archival samples. GigaScience, 4, 54. doi: 10.1186/s13742-015-0099-9

Purcell, R., Childs, M., Maibach, R., Miles, C., Turner, C., Zimmermann, A., … Sullivan, M. (2012). Potential biomarkers for hepatoblastoma: Results from the SIOPEL-3 study. European Journal of Cancer, 48(12), 1853-1859. doi: 10.1016/j.ejca.2011.10.019

Purcell, R., Childs, M., Maibach, R., Miles, C., Turner, C., Zimmermann, A., & Sullivan, M. (2011). HGF/c-Met related activation of β-catenin in hepatoblastoma. Journal of Experimental & Clinical Cancer Research, 30, 96. doi: 10.1186/1756-9966-30-96

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Conference Contribution - Published proceedings: Abstract

Purcell, R., Visnovska, M., Biggs, P., Schmeier, S., & Frizelle, F. (2017). Consensus molecular classification of colorectal cancer and association with the colonic microbiome. Proceedings of the American Society of Colon and Rectal Surgeons (ASCRS) Annual Scientific & Tripartite Meeting. (pp. 44-45). Retrieved from http://fascrs.org

Purcell, R., Sullivan, M., Maibach, R., Zimmermann, A., Miles, C., Turner, C., & Childs, M. (2011). HGF/C-met related activation of âeta-catenin in hepatoblastoma. Pediatric Blood & Cancer, 57(5), (pp. 728). doi: 10.1002/pbc.23299

Purcell, R., Sullivan, M., Maibach, R., Zimmermann, A., Turner, C., & Miles, C. (2011). Immunohistochemical analysis of hepatoblastomas reveals potential biomarkers. Pediatric Blood & Cancer, 57(5), (pp. 782). doi: 10.1002/pbc.23299

Sullivan, M., Purcell, R., & Arsic, D. (2007). Sonic hedgehog pathway inhibition induces caspase-related apoptotic cell death in hepatoblastoma. Pediatric Blood & Cancer, 49(Suppl. 6), PA.043, (pp. 450). doi: 10.1002/pbc.21342

Sullivan, M., Hale, T., Miles, C., & Purcell, R. (2007). A tumour tissue array for the validation of candidate biomarkers for hepatoblastoma treated according to the SIOPEL 2 and 3 clinical trials. Pediatric Blood & Cancer, 49(Suppl. 6), PA.044, (pp. 450). doi: 10.1002/pbc.21342

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Conference Contribution - Verbal presentation and other Conference outputs

Purcell, R. (2017, October). Distinct microbiome patterns associate with colorectal cancer molecular subtyptes. Verbal presentation at the New Zealand Society for Oncology (NZSO) Conference, Auckland, New Zealand.

Purcell, R. V., Visnovska, M., Biggs, P. J., Schmeier, S., & Frizelle, F. A. (2017, September). Distinct microbiome patterns associate with colorectal cancer molecular subtypes. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Purcell, R., Pearson, J., Keenan, J., Schmeier, S., & Frizelle, F. (2016, August-September). Bacterial dysbiosis and the development of colorectal cancer. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.

Purcell, R., Pearson, J., Visnovska, M., Schmeier, S., & Frizelle, F. (2016, November). Consensus molecular classification of colorectal cancer and association with the colonic microbiome. Verbal presentation at the Joint Meeting of the New Zealand Microbiological Society (NZMS) and the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB), Christchurch, New Zealand.

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