Dr Rachel Purcell

Purcell, R. V. (2020). Bacteroides fragilis. In M. H. Floch (Ed.), Colorectal neoplasia and the colorectal microbiome: Dysplasia, probiotics, and fusobacteria. (pp. 57-77). London, UK: Academic Press. doi: 10.1016/B978-0-12-819672-4.00004-0

Chapter in Book - Research

Lee, M. S., Purcell, R., McCombie, A., Frizelle, F., & Eglinton, T. (2023). Retrospective cohort study of the impact of faecoliths on the natural history of acute appendicitis. World Journal of Emergency Surgery, 18, 18. doi: 10.1186/s13017-023-00486-8

Journal - Research Article

Rodger, E. J., Gimenez, G., Ajithkumar, P., Stockwell, P. A., Almomani, S., Bowden, S. A., Leichter, A. L., Ahn, A., Pattison, S., McCall, J. L., … Frizelle, F. A., Eccles, M. R., Purcell, R. V., & Chatterjee, A. (2023). An epigenetic signature of advanced colorectal cancer metastasis. iScience. Advance online publication. doi: 10.1016/j.isci.2023.106986

Journal - Research Article

Sulit, A. K., Wilson, K., Pearson, J., Silander, O. K., Sampurno, S., Michael, M., … Frizelle, F., & Purcell, R. V. (2023). Human gene and microbial analyses in rectal cancer complete responses to radiotherapy. BJS Open, 7(3), zrad035. doi: 10.1093/bjsopen/zrad035

Journal - Research Article

Thompson, N., Gatenby, G., Waddell, O., Purcell, R., Keenan, J., Pearson, J., Frizelle, F., & Glyn, T. (2023). Early onset colorectal cancer in Canterbury, New Zealand. ANZ Journal of Surgery. Advance online publication. doi: 10.1111/ans.18357

Journal - Research Article

Aitchison, A., Pearson, J. F., Purcell, R. V., Frizelle, F. A., & Keenan, J. I. (2022). Detection of Fusobacterium nucleatum DNA in primary care patient stool samples does not predict progression of colorectal neoplasia. PLoS ONE, 17(6), e0269541. doi: 10.1371/journal.pone.0269541

Journal - Research Article

Curio, S., Edwards, S. C., Suzuki, T., McGovern, J., Triulzi, C., Yoshida, N., … Purcell, R. V., … Guerra, N. (2022). NKG2D signaling regulates IL-17A-producing γδT cells in mice to promote cancer progression. Discovery Immunology, 1, kyac002. doi: 10.1093/discim/kyac002

Journal - Research Article

Lee, M. S., Thomas, A., Pearson, J. F., Purcell, R., Frizelle, F., & Glyn, T. (2022). Risk of colorectal cancer in patients with appendicitis over the age of 40 years. Colorectal Disease. Advance online publication. doi: 10.1111/codi.16429

Journal - Research Article

O'Grady, M. J., Turner, G. A., Sulit, A., Frizelle, F. A., & Purcell, R. (2022). Distinct changes in the colonic microbiome associated with acute diverticulitis. Colorectal Disease. Advance online publication. doi: 10.1111/codi.16271

Journal - Research Article

Purcell, R. V., Permain, J., & Keenan, J. I. (2022). Enterotoxigenic Bacteroides fragilis activates IL-8 expression through Stat3 in colorectal cancer cells. Gut Pathogens, 14, 16. doi: 10.1186/s13099-022-00489-x

Journal - Research Article

Turner, G., O'Grady, M., Hudson, D., Morgan, X., Frizelle, F., & Purcell, R. (2022). Rectal swabs are a reliable method of assessing the colonic microbiome. International Journal of Medical Microbiology, 312(2), 151549. doi: 10.1016/j.ijmm.2022.151549

Journal - Research Article

Lau, Y. C., Schmeier, S., Frizelle, F., & Purcell, R. (2021). Consensus molecular subtypes of primary colon tumors and their hepatic metastases. Future Science OA, 7(7), FSO722. doi: 10.2144/fsoa-2021-0021

Journal - Research Article

Turner, G. A., O'Grady, M. J., Senadeera, S. C., Wakeman, C. J., McCombie, A., Purcell, R. V., & Frizelle, F. A. (2021). The prevalence of right-sided colonic diverticulosis in a New Zealand population. ANZ Journal of Surgery, 91, 2110-2114. doi: 10.1111/ans.16995

Journal - Research Article

O'Grady, M., Clarke, L., Turner, G., Doogue, M., Purcell, R., Pearson, J., & Frizelle, F. (2020). Statin use and risk of acute diverticulitis: A population-based case-control study. Medicine, 99(20), e20264. doi: 10.1097/md.0000000000020264

Journal - Research Article

O'Grady, M., Turner, G., Currie, W., Yi, M., Frizelle, F., & Purcell, R. (2020). Acute diverticulitis: An ongoing economic burden on the health system. ANZ Journal of Surgery, 90, 2046-2049. doi: 10.1111/ans.16234

Journal - Research Article

Taylor, W. S., Pearson, J., Miller, A., Schmeier, S., Frizelle, F. A., & Purcell, R. V. (2020). MinION sequencing of colorectal cancer tumour microbiomes: A comparison with amplicon-based and RNA-sequencing. PLoS ONE, 15(5), e0233170. doi: 10.1371/journal.pone.0233170

Journal - Research Article

Purcell, R. V., Schmeier, S., Lau, Y. C., Pearson, J. F., & Frizelle, F. A. (2019). Molecular subtyping improves prognostication of Stage 2 colorectal cancer. BMC Cancer, 19(1), 1155. doi: 10.1186/s12885-019-6327-4

Journal - Research Article

Stevens, A. J., Purcell, R. V., Darling, K. A., Eggleston, M. J. F., Kennedy, M. A., & Rucklidge, J. J. (2019). Human gut microbiome changes during a 10 week randomised control trial for micronutrient supplementation in children with attention deficit hyperactivity disorder. Scientific Reports, 9, 10128. doi: 10.1038/s41598-019-46146-3

Journal - Research Article

Purcell, R. V., Kaakoush, N. O., Mitchell, H. M., Pearson, J. F., & Keenan, J. I. (2018). Gastrointestinal pathobionts in pediatric Crohn's disease patients. International Journal of Microbiology, 2018, 9203908. doi: 10.1155/2018/9203908

Journal - Research Article

Purcell, R. V., Pearson, J., Aitchison, A., Dixon, L., Frizelle, F. A., & Keenan, J. I. (2017). Colonization with enterotoxigenic Bacteroides fragilis is associated with early-stage colorectal neoplasia. PLoS ONE, 12(2), e0171602. doi: 10.1371/journal.pone.0171602

Journal - Research Article

Purcell, R. V., Visnovska, M., Biggs, P. J., Schmeier, S., & Frizelle, F. A. (2017). Distinct gut microbiome patterns associate with consensus molecular subtypes of colorectal cancer. Scientific Reports, 7, 11590. doi: 10.1038/s41598-017-11237-6

Journal - Research Article

Keenan, J. I., Aitchison, A., Purcell, R. V., Greenlees, R., Pearson, J. F., & Frizelle, F. A. (2016). Screening for enterotoxigenic Bacteroides fragilis in stool samples. Anaerobe, 40, 50-53. doi: 10.1016/j.anaerobe.2016.05.004

Journal - Research Article

Purcell, R. V., Pearson, J., Frizelle, F. A., & Keenan, J. I. (2016). Comparison of standard, quantitative and digital PCR in the detection of enterotoxigenic Bacteroides fragilis. Scientific Reports, 6, 34554. doi: 10.1038/srep34554

Journal - Research Article

Chatterjee, A., Leichter, A. L., Fan, V., Tsai, P., Purcell, R. V., Sullivan, M. J., & Eccles, M. R. (2015). A cross comparison of technologies for the detection of microRNAs in clinical FFPE samples of hepatoblastoma patients. Scientific Reports, 5, 10438. doi: 10.1038/srep10438

Journal - Research Article

Leichter, A. L., Purcell, R. V., Sullivan, M. J., Eccles, M. R., & Chatterjee, A. (2015). Multi-platform microRNA profiling of hepatoblastoma patients using formalin fixed paraffin embedded archival samples. GigaScience, 4, 54. doi: 10.1186/s13742-015-0099-9

Journal - Research Article

Purcell, R., Childs, M., Maibach, R., Miles, C., Turner, C., Zimmermann, A., … Sullivan, M. (2012). Potential biomarkers for hepatoblastoma: Results from the SIOPEL-3 study. European Journal of Cancer, 48(12), 1853-1859. doi: 10.1016/j.ejca.2011.10.019

Journal - Research Article

Purcell, R., Childs, M., Maibach, R., Miles, C., Turner, C., Zimmermann, A., & Sullivan, M. (2011). HGF/c-Met related activation of β-catenin in hepatoblastoma. Journal of Experimental & Clinical Cancer Research, 30, 96. doi: 10.1186/1756-9966-30-96

Journal - Research Article

Glyn, T., & Purcell, R. (2022). Circulating bacterial DNA: A new paradigm for cancer diagnostics [Mini review]. Frontiers in Medicine, 9, 831096. doi: 10.3389/fmed.2022.831096

Journal - Research Other

Noble, A. J., Purcell, R. V., Adams, A. T., Lam, Y. K., Ring, P. M., Anderson, J. R., & Osborne, A. J. (2022). A final frontier in environment-genome interactions? Integrated, multi-omic approaches to predictions of non-communicable disease risk. Frontiers in Genetics, 13, 831866. doi: 10.3389/fgene.2022.831866

Journal - Research Other

Shelling, A. N., Bicknell, L. S., Bohlander, S. S., Cox, M. P., Filoche, S. K., Fraser, H. G., … Te Aika, B., Purcell, R. V., & Tiller, J. M. (2022). Genomic discrimination in New Zealand health and life insurance: AGenDA: Against Genomic Discrimination in Aotearoa. New Zealand Medical Journal, 135(1551), 7-12. Retrieved from https://www.nzma.org.nz/journal

Journal - Research Other

Turner, G. A., O'Grady, M. J., Purcell, R. V., & Frizelle, F. A. (2022). Acute diverticulitis in young patients: A review of the changing epidemiology and etiology. Digestive Diseases & Sciences, 67, 1156-1162. doi: 10.1007/s10620-021-06956-w

Journal - Research Other

Turner, G. A., O'Grady, M. J., Purcell, R. V., & Frizelle, F. A. (2021). The epidemiology and etiology of right-sided colonic diverticulosis: A review. Annals of Coloproctology, 37(4), 196-203. doi: 10.3393/ac.2021.00192.0027

Journal - Research Other

Purcell, R. V., Hock, B. D., Gardner, J., Goddard, L., MacPherson, S. A., & McKenzie, J. L. (2019). Analysis of human papillomavirus infection and leukaemic infiltrate in cutaneous squamous cell carcinoma from patients with chronic lymphocytic leukaemia. British Journal of Haematology, 186(4), e67-e71. doi: 10.1111/bjh.15907

Journal - Research Other

Visnovska, T., Biggs, P. J., Schmeier, S., Frizelle, F. A., & Purcell, R. V. (2019). Metagenomics and transcriptomics data from human colorectal cancer [Data descriptor]. Scientific Data, 6(1), 116. doi: 10.1038/s41597-019-0117-3

Journal - Research Other

Permain, J., Purcell, R., Sulit, A., Hock, B., & Eglinton, T. (2022). Novel functional links between colorectal carcinogenesis and the microbiome. Colorectal Disease, 24(Suppl. 1), (pp. 4-5). doi: 10.1111/codi.16048

Conference Contribution - Published proceedings: Abstract

Purcell, R., Sulit, A., Wilson, K., Michael, M., Pearson, J., Ramsey, R., … Frizelle, F. (2022). The tumour microbiome and response to radiotherapy in rectal cancer. Colorectal Disease, 24(Suppl. 1), (pp. 5). doi: 10.1111/codi.16048

Conference Contribution - Published proceedings: Abstract

Sulit, A., Daigneault, M., Allen-Vercoe, E., Silander, O., Hock, B., McKenzie, J., Pearson, J., Frizelle, F., … Purcell, R. (2022). Lipopolysaccharide from colorectal cancer-associated bacteria influence cytokine production in immune cells. Colorectal Disease, 24(Suppl. 1), (pp. 55-56). doi: 10.1111/codi.16048

Conference Contribution - Published proceedings: Abstract

Purcell, R., Visnovska, M., Biggs, P., Schmeier, S., & Frizelle, F. (2017). Consensus molecular classification of colorectal cancer and association with the colonic microbiome. Proceedings of the American Society of Colon and Rectal Surgeons (ASCRS) Annual Scientific & Tripartite Meeting. (pp. 44-45). Retrieved from http://fascrs.org

Conference Contribution - Published proceedings: Abstract

Purcell, R., Sullivan, M., Maibach, R., Zimmermann, A., Miles, C., Turner, C., & Childs, M. (2011). HGF/C-met related activation of âeta-catenin in hepatoblastoma. Pediatric Blood & Cancer, 57(5), (pp. 728). doi: 10.1002/pbc.23299

Conference Contribution - Published proceedings: Abstract

Purcell, R., Sullivan, M., Maibach, R., Zimmermann, A., Turner, C., & Miles, C. (2011). Immunohistochemical analysis of hepatoblastomas reveals potential biomarkers. Pediatric Blood & Cancer, 57(5), (pp. 782). doi: 10.1002/pbc.23299

Conference Contribution - Published proceedings: Abstract

Sullivan, M., Hale, T., Miles, C., & Purcell, R. (2007). A tumour tissue array for the validation of candidate biomarkers for hepatoblastoma treated according to the SIOPEL 2 and 3 clinical trials. Pediatric Blood & Cancer, 49(Suppl. 6), PA.044, (pp. 450). doi: 10.1002/pbc.21342

Conference Contribution - Published proceedings: Abstract

Sullivan, M., Purcell, R., & Arsic, D. (2007). Sonic hedgehog pathway inhibition induces caspase-related apoptotic cell death in hepatoblastoma. Pediatric Blood & Cancer, 49(Suppl. 6), PA.043, (pp. 450). doi: 10.1002/pbc.21342

Conference Contribution - Published proceedings: Abstract

Sulit, A. K., Pearson, J., Liu, W., Silander, O. K., Wilson, K., Heriot, A., Frizelle, F., & Purcell, R. (2022, August). Human gene and microbial analyses suggest immunotherapy-like mechanisms in complete response to radiotherapy in rectal cancer. Verbal presentation at the Cancer Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Purcell, R. (2017, October). Distinct microbiome patterns associate with colorectal cancer molecular subtyptes. Verbal presentation at the New Zealand Society for Oncology (NZSO) Conference, Auckland, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Purcell, R. V., Visnovska, M., Biggs, P. J., Schmeier, S., & Frizelle, F. A. (2017, September). Distinct microbiome patterns associate with colorectal cancer molecular subtypes. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Purcell, R., Pearson, J., Keenan, J., Schmeier, S., & Frizelle, F. (2016, August-September). Bacterial dysbiosis and the development of colorectal cancer. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Purcell, R., Pearson, J., Visnovska, M., Schmeier, S., & Frizelle, F. (2016, November). Consensus molecular classification of colorectal cancer and association with the colonic microbiome. Verbal presentation at the Joint Meeting of the New Zealand Microbiological Society (NZMS) and the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB), Christchurch, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Purcell, R. (2011). Molecular mechanisms in the pathogenesis of hepatoblastoma (PhD). University of Otago, Dunedin, New Zealand. Retrieved from http://hdl.handle.net/10523/1841

Awarded Doctoral Degree