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Dr Rachel Purcell

Rachel PurcellSenior Research Fellow

BSc(Hons)(Cork) MSc(Hons)(PIC) PhD(Otago)

Email rachel.purcell@otago.ac.nz

Rachel is a Senior Research Fellow with the Department of Surgery. She has a background in molecular biology and cancer genetics.

Her research is centred on the molecular mechanisms of pathogenic bacteria in colorectal carcinogenesis.

Rachel's current research projects include investigating the effect of the gut microbiome on radiotherapy response in rectal cancer, microbiome-based markers of diverticular disease and molecular classification of colorectal cancer..

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Publications

Turner, G. A., O'Grady, M. J., Purcell, R. V., & Frizelle, F. A. (2021). The epidemiology and etiology of right-sided colonic diverticulosis: A review. Annals of Coloproctology. Advance online publication. doi: 10.3393/ac.2021.00192.0027

Turner, G. A., O'Grady, M. J., Senadeera, S. C., Wakeman, C. J., McCombie, A., Purcell, R. V., & Frizelle, F. A. (2021). The prevalence of right-sided colonic diverticulosis in a New Zealand population. ANZ Journal of Surgery. Advance online publication. doi: 10.1111/ans.16995

Lau, Y. C., Schmeier, S., Frizelle, F., & Purcell, R. (2021). Consensus molecular subtypes of primary colon tumors and their hepatic metastases. Future Science OA. Advance online publication. doi: 10.2144/fsoa-2021-0021

Turner, G. A., O'Grady, M. J., Purcell, R. V., & Frizelle, F. A. (2021). Acute diverticulitis in young patients: A review of the changing epidemiology and etiology. Digestive Diseases & Sciences. Advance online publication. doi: 10.1007/s10620-021-06956-w

Purcell, R. V. (2020). Bacteroides fragilis. In M. H. Floch (Ed.), Colorectal neoplasia and the colorectal microbiome: Dysplasia, probiotics, and fusobacteria. (pp. 57-77). London, UK: Academic Press. doi: 10.1016/B978-0-12-819672-4.00004-0

Purcell, R. V. (2020). Bacteroides fragilis. In M. H. Floch (Ed.), Colorectal neoplasia and the colorectal microbiome: Dysplasia, probiotics, and fusobacteria. (pp. 57-77). London, UK: Academic Press. doi: 10.1016/B978-0-12-819672-4.00004-0

Chapter in Book - Research

Lau, Y. C., Schmeier, S., Frizelle, F., & Purcell, R. (2021). Consensus molecular subtypes of primary colon tumors and their hepatic metastases. Future Science OA. Advance online publication. doi: 10.2144/fsoa-2021-0021

Journal - Research Article

Turner, G. A., O'Grady, M. J., Senadeera, S. C., Wakeman, C. J., McCombie, A., Purcell, R. V., & Frizelle, F. A. (2021). The prevalence of right-sided colonic diverticulosis in a New Zealand population. ANZ Journal of Surgery. Advance online publication. doi: 10.1111/ans.16995

Journal - Research Article

O'Grady, M., Clarke, L., Turner, G., Doogue, M., Purcell, R., Pearson, J., & Frizelle, F. (2020). Statin use and risk of acute diverticulitis: A population-based case-control study. Medicine, 99(20), e20264. doi: 10.1097/md.0000000000020264

Journal - Research Article

O'Grady, M., Turner, G., Currie, W., Yi, M., Frizelle, F., & Purcell, R. (2020). Acute diverticulitis: An ongoing economic burden on the health system. ANZ Journal of Surgery, 90, 2046-2049. doi: 10.1111/ans.16234

Journal - Research Article

Taylor, W. S., Pearson, J., Miller, A., Schmeier, S., Frizelle, F. A., & Purcell, R. V. (2020). MinION sequencing of colorectal cancer tumour microbiomes: A comparison with amplicon-based and RNA-sequencing. PLoS ONE, 15(5), e0233170. doi: 10.1371/journal.pone.0233170

Journal - Research Article

Purcell, R. V., Schmeier, S., Lau, Y. C., Pearson, J. F., & Frizelle, F. A. (2019). Molecular subtyping improves prognostication of Stage 2 colorectal cancer. BMC Cancer, 19(1), 1155. doi: 10.1186/s12885-019-6327-4

Journal - Research Article

Stevens, A. J., Purcell, R. V., Darling, K. A., Eggleston, M. J. F., Kennedy, M. A., & Rucklidge, J. J. (2019). Human gut microbiome changes during a 10 week randomised control trial for micronutrient supplementation in children with attention deficit hyperactivity disorder. Scientific Reports, 9, 10128. doi: 10.1038/s41598-019-46146-3

Journal - Research Article

Purcell, R. V., Kaakoush, N. O., Mitchell, H. M., Pearson, J. F., & Keenan, J. I. (2018). Gastrointestinal pathobionts in pediatric Crohn's disease patients. International Journal of Microbiology, 2018, 9203908. doi: 10.1155/2018/9203908

Journal - Research Article

Purcell, R. V., Pearson, J., Aitchison, A., Dixon, L., Frizelle, F. A., & Keenan, J. I. (2017). Colonization with enterotoxigenic Bacteroides fragilis is associated with early-stage colorectal neoplasia. PLoS ONE, 12(2), e0171602. doi: 10.1371/journal.pone.0171602

Journal - Research Article

Purcell, R. V., Visnovska, M., Biggs, P. J., Schmeier, S., & Frizelle, F. A. (2017). Distinct gut microbiome patterns associate with consensus molecular subtypes of colorectal cancer. Scientific Reports, 7, 11590. doi: 10.1038/s41598-017-11237-6

Journal - Research Article

Keenan, J. I., Aitchison, A., Purcell, R. V., Greenlees, R., Pearson, J. F., & Frizelle, F. A. (2016). Screening for enterotoxigenic Bacteroides fragilis in stool samples. Anaerobe, 40, 50-53. doi: 10.1016/j.anaerobe.2016.05.004

Journal - Research Article

Purcell, R. V., Pearson, J., Frizelle, F. A., & Keenan, J. I. (2016). Comparison of standard, quantitative and digital PCR in the detection of enterotoxigenic Bacteroides fragilis. Scientific Reports, 6, 34554. doi: 10.1038/srep34554

Journal - Research Article

Chatterjee, A., Leichter, A. L., Fan, V., Tsai, P., Purcell, R. V., Sullivan, M. J., & Eccles, M. R. (2015). A cross comparison of technologies for the detection of microRNAs in clinical FFPE samples of hepatoblastoma patients. Scientific Reports, 5, 10438. doi: 10.1038/srep10438

Journal - Research Article

Leichter, A. L., Purcell, R. V., Sullivan, M. J., Eccles, M. R., & Chatterjee, A. (2015). Multi-platform microRNA profiling of hepatoblastoma patients using formalin fixed paraffin embedded archival samples. GigaScience, 4, 54. doi: 10.1186/s13742-015-0099-9

Journal - Research Article

Purcell, R., Childs, M., Maibach, R., Miles, C., Turner, C., Zimmermann, A., … Sullivan, M. (2012). Potential biomarkers for hepatoblastoma: Results from the SIOPEL-3 study. European Journal of Cancer, 48(12), 1853-1859. doi: 10.1016/j.ejca.2011.10.019

Journal - Research Article

Purcell, R., Childs, M., Maibach, R., Miles, C., Turner, C., Zimmermann, A., & Sullivan, M. (2011). HGF/c-Met related activation of β-catenin in hepatoblastoma. Journal of Experimental & Clinical Cancer Research, 30, 96. doi: 10.1186/1756-9966-30-96

Journal - Research Article

Turner, G. A., O'Grady, M. J., Purcell, R. V., & Frizelle, F. A. (2021). Acute diverticulitis in young patients: A review of the changing epidemiology and etiology. Digestive Diseases & Sciences. Advance online publication. doi: 10.1007/s10620-021-06956-w

Journal - Research Other

Turner, G. A., O'Grady, M. J., Purcell, R. V., & Frizelle, F. A. (2021). The epidemiology and etiology of right-sided colonic diverticulosis: A review. Annals of Coloproctology. Advance online publication. doi: 10.3393/ac.2021.00192.0027

Journal - Research Other

Purcell, R. V., Hock, B. D., Gardner, J., Goddard, L., MacPherson, S. A., & McKenzie, J. L. (2019). Analysis of human papillomavirus infection and leukaemic infiltrate in cutaneous squamous cell carcinoma from patients with chronic lymphocytic leukaemia. British Journal of Haematology, 186(4), e67-e71. doi: 10.1111/bjh.15907

Journal - Research Other

Visnovska, T., Biggs, P. J., Schmeier, S., Frizelle, F. A., & Purcell, R. V. (2019). Metagenomics and transcriptomics data from human colorectal cancer [Data descriptor]. Scientific Data, 6(1), 116. doi: 10.1038/s41597-019-0117-3

Journal - Research Other

Purcell, R., Visnovska, M., Biggs, P., Schmeier, S., & Frizelle, F. (2017). Consensus molecular classification of colorectal cancer and association with the colonic microbiome. Proceedings of the American Society of Colon and Rectal Surgeons (ASCRS) Annual Scientific & Tripartite Meeting. (pp. 44-45). Retrieved from http://fascrs.org

Conference Contribution - Published proceedings: Abstract

Purcell, R., Sullivan, M., Maibach, R., Zimmermann, A., Miles, C., Turner, C., & Childs, M. (2011). HGF/C-met related activation of âeta-catenin in hepatoblastoma. Pediatric Blood & Cancer, 57(5), (pp. 728). doi: 10.1002/pbc.23299

Conference Contribution - Published proceedings: Abstract

Purcell, R., Sullivan, M., Maibach, R., Zimmermann, A., Turner, C., & Miles, C. (2011). Immunohistochemical analysis of hepatoblastomas reveals potential biomarkers. Pediatric Blood & Cancer, 57(5), (pp. 782). doi: 10.1002/pbc.23299

Conference Contribution - Published proceedings: Abstract

Sullivan, M., Hale, T., Miles, C., & Purcell, R. (2007). A tumour tissue array for the validation of candidate biomarkers for hepatoblastoma treated according to the SIOPEL 2 and 3 clinical trials. Pediatric Blood & Cancer, 49(Suppl. 6), PA.044, (pp. 450). doi: 10.1002/pbc.21342

Conference Contribution - Published proceedings: Abstract

Sullivan, M., Purcell, R., & Arsic, D. (2007). Sonic hedgehog pathway inhibition induces caspase-related apoptotic cell death in hepatoblastoma. Pediatric Blood & Cancer, 49(Suppl. 6), PA.043, (pp. 450). doi: 10.1002/pbc.21342

Conference Contribution - Published proceedings: Abstract

Purcell, R. (2017, October). Distinct microbiome patterns associate with colorectal cancer molecular subtyptes. Verbal presentation at the New Zealand Society for Oncology (NZSO) Conference, Auckland, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Purcell, R. V., Visnovska, M., Biggs, P. J., Schmeier, S., & Frizelle, F. A. (2017, September). Distinct microbiome patterns associate with colorectal cancer molecular subtypes. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Purcell, R., Pearson, J., Keenan, J., Schmeier, S., & Frizelle, F. (2016, August-September). Bacterial dysbiosis and the development of colorectal cancer. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Purcell, R., Pearson, J., Visnovska, M., Schmeier, S., & Frizelle, F. (2016, November). Consensus molecular classification of colorectal cancer and association with the colonic microbiome. Verbal presentation at the Joint Meeting of the New Zealand Microbiological Society (NZMS) and the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB), Christchurch, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Purcell, R. (2011). Molecular mechanisms in the pathogenesis of hepatoblastoma (PhD). University of Otago, Dunedin, New Zealand. Retrieved from http://hdl.handle.net/10523/1841

Awarded Doctoral Degree

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