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Sharon Gardiner

Antimicrobial Pharmacist

BPharm(Hons), MClinPharm, PhD

Email sharon.gardiner@cdhb.health.nz

Sharon Gardiner is the antimicrobial pharmacist for CDHB, in a joint position between the departments of Clinical Pharmacology, Infectious Diseases and Pharmacy.

Her research interests include drug safety in breastfeeding, antibiotic dosing regimens and pharmacogenetics.

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Publications

Everts, R. J., Gardiner, S. J., Zhang, M., Begg, R., Chambers, S. T., Turnidge, J., & Begg, E. J. (2021). Probenecid effects on cephalexin pharmacokinetics and pharmacodynamics in healthy volunteers. Journal of Infection. Advance online publication. doi: 10.1016/j.jinf.2021.05.037

Drennan, P. G., Green, J. K., Gardiner, S. J., Metcalf, S. C. L., Kirkpatrick, C. M. J., Everts, R. J., Zhang, M., & Chambers, S. T. (2021). Population pharmacokinetics of free flucloxacillin in patients treated with oral flucloxacillin plus probenecid. British Journal of Clinical Pharmacology. Advance online publication. doi: 10.1111/bcp.14887

Gardiner, S. J., Basevi, A. B., Hamilton, N. L., Metcalf, S. C. L., Chambers, S. T., Withington, S. G., Chin, P. K., Freeman, J. T., Dalton, S. C., on behalf of the Canterbury District Health Board Antimicrobial Stewardship Committee. (2020). Point prevalence surveys of antimicrobial use in adult inpatients at Canterbury District Health Board hospitals. New Zealand Medical Journal, 133(1525), 18-33. Retrieved from https://www.nzma.org.nz/journal

Chambers, S. T., Long, M., Gardiner, S. J., Chin, P. K. L., Yi, M., Dalton, S. C., … Metcalf, S. C. L. (2020). Determinants of vancomycin nephrotoxicity when administered to outpatients as a continuous 24-hour infusion. International Journal of Antimicrobial Agents, 55, 105972. doi: 10.1016/j.ijantimicag.2020.105972

Gardiner, S. J., Metcalf, S. C. L., Werno, A., Doogue, M. P., Chambers, S. T., on behalf of the Canterbury District Health Board Antimicrobial Stewardship Committee. (2020). A persuasive approach to antimicrobial stewardship in Christchurch hospitals produced a sustained decrease in intravenous clarithromycin dosing and expenditure via a switch to azithromycin orally. New Zealand Medical Journal, 133(1512), 22-30. Retrieved from https://www.nzma.org.nz/journal

Begg, E., Barclay, M., Vella-Brincat, J., Gardiner, S. J., Doogue, M., McDermott, L., … Chambers, S., & Murdoch, D. (Eds.). (2004). Preferred Medicines List (8th ed.). Christchurch: The Caxton Press, 172p.

Edited Book - Other

Gardiner, S. J., Kirkpatrick, C. M. J., & Begg, E. J. (2015). Lactation and contamination of breast milk with Xenobiotics. In M. J. Caplan (Ed.), Reference module in biomedical sciences. Elsevier. doi: 10.1016/B978-0-12-801238-3.02154-1

Chapter in Book - Research

Begg, E. J., Gardiner, S. J., & Kirkpatrick, C. M. J. (2010). Lactation and contamination of breast milk with xenobiotics. In C. A. McQueen (Ed.), Comprehensive toxicology. (2nd ed.) (pp. 445-455). Oxford, UK: Elsevier.

Chapter in Book - Research

Gardiner, S. J., & Woods, D. J. (2007). Drugs in pregnancy and lactation. In R. Walker & C. Whittlesea (Eds.), Clinical pharmacy and therapeutics. (4th ed.) (pp. 681-690). Edinburgh, Scotland: Churchill Livingstone.

Chapter in Book - Other

Drennan, P. G., Green, J. K., Gardiner, S. J., Metcalf, S. C. L., Kirkpatrick, C. M. J., Everts, R. J., Zhang, M., & Chambers, S. T. (2021). Population pharmacokinetics of free flucloxacillin in patients treated with oral flucloxacillin plus probenecid. British Journal of Clinical Pharmacology. Advance online publication. doi: 10.1111/bcp.14887

Journal - Research Article

Everts, R. J., Gardiner, S. J., Zhang, M., Begg, R., Chambers, S. T., Turnidge, J., & Begg, E. J. (2021). Probenecid effects on cephalexin pharmacokinetics and pharmacodynamics in healthy volunteers. Journal of Infection. Advance online publication. doi: 10.1016/j.jinf.2021.05.037

Journal - Research Article

Chambers, S. T., Long, M., Gardiner, S. J., Chin, P. K. L., Yi, M., Dalton, S. C., … Metcalf, S. C. L. (2020). Determinants of vancomycin nephrotoxicity when administered to outpatients as a continuous 24-hour infusion. International Journal of Antimicrobial Agents, 55, 105972. doi: 10.1016/j.ijantimicag.2020.105972

Journal - Research Article

Everts, R. J., Begg, R., Gardiner, S. J., Zhang, M., Turnidge, J., Chambers, S. T., & Begg, E. J. (2020). Probenecid and food effects on flucloxacillin pharmacokinetics and pharmacodynamics in healthy volunteers. Journal of Infection, 80, 42-53. doi: 10.1016/j.jinf.2019.09.004

Journal - Research Article

Gardiner, S. J., Basevi, A. B., Hamilton, N. L., Metcalf, S. C. L., Chambers, S. T., Withington, S. G., Chin, P. K., Freeman, J. T., Dalton, S. C., on behalf of the Canterbury District Health Board Antimicrobial Stewardship Committee. (2020). Point prevalence surveys of antimicrobial use in adult inpatients at Canterbury District Health Board hospitals. New Zealand Medical Journal, 133(1525), 18-33. Retrieved from https://www.nzma.org.nz/journal

Journal - Research Article

Gardiner, S. J., Metcalf, S. C. L., Werno, A., Doogue, M. P., Chambers, S. T., on behalf of the Canterbury District Health Board Antimicrobial Stewardship Committee. (2020). A persuasive approach to antimicrobial stewardship in Christchurch hospitals produced a sustained decrease in intravenous clarithromycin dosing and expenditure via a switch to azithromycin orally. New Zealand Medical Journal, 133(1512), 22-30. Retrieved from https://www.nzma.org.nz/journal

Journal - Research Article

Chin, P. K. L., Drennan, P. G., Gardiner, S. J., Zhang, M., Dalton, S. C., Chambers, S. T., & Begg, E. J. (2018). Total flucloxacillin plasma concentrations poorly reflect unbound concentrations in hospitalised patients with Staphylococcus aureus bacteraemia. British Journal of Clinical Pharmacology, 84(10), 2311-2316. doi: 10.1111/bcp.13673

Journal - Research Article

Gardiner, S. J., Drennan, P. G., Begg, R., Zhang, M., Green, J. K., Isenman, H. L., Everts, R. J., Chambers, S. T., & Begg, E. J. (2018). In healthy volunteers, taking flucloxacillin with food does not compromise effective plasma concentrations in most circumstances. PLoS ONE, 13(7), e0199370. doi: 10.1371/journal.pone.0199370

Journal - Research Article

Gardiner, S. J., Metcalf, S. C. L., Chin, P. K. L., Doogue, M. P., Dalton, S. C., & Chambers, S. T. (2018). Metronidazole stewardship initiative at Christchurch hospitals: Achievable with immediate benefits. New Zealand Medical Journal, 131(1473), 53-58. Retrieved from https://www.nzma.org.nz/journal

Journal - Research Article

Green, J. K., Gardiner, S. J., Clarke, S. L., Thompson, L., Metcalf, S. C. L., & Chambers, S. T. (2018). Antimicrobial stewardship practice in New Zealand's rural hospitals. New Zealand Medical Journal, 131(1481), 16-26. Retrieved from https://www.nzma.org.nz/journal

Journal - Research Article

Gardiner, S. J., Pryer, J. A., & Duffy, E. J. (2017). Survey of antimicrobial stewardship practices in public hospitals in New Zealand district health boards. New Zealand Medical Journal, 130(1458), 27-41. Retrieved from http://www.nzma.org.nz/journal

Journal - Research Article

Gardiner, S. J., Gearry, R. B., Burt, M. J., Chalmers-Watson, T., Chapman, B. A., Ross, A. G., Stedman, C. A. M., … Barclay, M. L. (2011). Allopurinol might improve response to azathioprine and 6-mercaptopurine by correcting an unfavorable metabolite ratio. Journal of Gastroenterology & Hepatology, 26(1), 49-54. doi: 10.1111/j.1440-1746.2010.06489.x

Journal - Research Article

Sharp, C. F., Gardiner, S. J., Jensen, B. P., Roberts, R. L., Troughton, R. W., Lainchbury, J. G., & Begg, E. J. (2009). CYP2D6 genotype and its relationship with metoprolol dose, concentrations and effect in patients with systolic heart failure. Pharmacogenomics Journal, 9(3), 175-184. doi: 10.1038/tpj.2009.9

Journal - Research Article

Gardiner, S. J., Gearry, R. B., Begg, E. J., Zhang, M., & Barclay, M. L. (2008). Thiopurine dose in intermediate and normal metabolizers of thiopurine methyltransferase may differ three-fold. Clinical Gastroenterology & Hepatology, 6(6), 654-660. doi: 10.1016/j.cgh.2008.02.032

Journal - Research Article

Gardiner, S. J., Gearry, R. B., Burt, M. J., Ding, S. L., & Barclay, M. L. (2008). Severe hepatotoxicity with high 6-methylmercaptopurine nucleotide concentrations after thiopurine dose escalation due to low 6-thioguanine nucleotides. European Journal of Gastroenterology & Hepatology, 20(12), 1238-1242. doi: 10.1097/MEG.0b013e3282ffda37

Journal - Research Article

Jensen, B. P., Sharp, C. F., Gardiner, S. J., & Begg, E. J. (2008). Development and validation of a stereoselective liquid chromatography-tandem mass spectrometry assay for quantification of S- and R-metoprolol in human plasma. Journal of Chromatography B, 865(1-2), 48-54. doi: 10.1016/j.jchromb.2008.02.006

Journal - Research Article

Gardiner, S. J., & Begg, E. J. (2006). Breastfeeding during tacrolimus therapy. Obstetrics & Gynecology, 107(2, Part 2, Suppl.), 453-455.

Journal - Research Article

Gardiner, S. J., & Begg, E. J. (2006). Pharmacogenetics, drug-metabolizing enzymes, and clinical practice. Pharmacological Reviews, 58(3), 521-590.

Journal - Research Article

Gardiner, S. J., Doogue, M. P., Zhang, M., & Begg, E. J. (2006). Quantification of infant exposure to celecoxib through breast milk. British Journal of Clinical Pharmacology, 61(1), 101-104. doi: 10.1111/j.1365-2125.2005.02520.x

Journal - Research Article

Gardiner, S. J., Gearry, R. B., Barclay, M. L., & Begg, E. J. (2006). Two cases of thiopurine methyltransferase (TPMT) deficiency: A lucky save and a near miss with azathioprine. British Journal of Clinical Pharmacology, 62(4), 473-476. doi: 10.1111/j.1365-2125.2005.02474.x

Journal - Research Article

Gardiner, S. J., Gearry, R. B., Roberts, R. L., Zhang, M., Barclay, M. L., & Begg, E. J. (2006). Exposure to thiopurine drugs through breast milk is low based on metabolite concentrations in mother-infant pairs. British Journal of Clinical Pharmacology, 62(4), 453-456.

Journal - Research Article

Hughes, R. C., Gardiner, S. J., Begg, E. J., & Zhang, M. (2006). Effect of pregnancy on the pharmacokinetics of metformin. Diabetic Medicine, 23(3), 323-326. doi: 10.1111/j.1464-5491.2005.01769.x

Journal - Research Article

Priest, V. L., Begg, E. J., Gardiner, S. J., Frampton, C. M., Gearry, R. B., Barclay, M. L., Clark, D. W., & Hansen, P. (2006). Pharmacoeconomic analyses of azathioprine, methotrexate and prospective pharmacogenetic testing for the management of inflammatory bowel disease. Pharmacoeconomics, 24(8), 767-781.

Journal - Research Article

Zhang, M., Moore, G. A., Gardiner, S. J., & Begg, E. J. (2006). Determination of celecoxib in human plasma and breast milk by high-performance liquid chromatographic assay. Journal of Chromatography B, 830(2), 245-248. doi: 10.1016/j.jchromb.2005.10.048

Journal - Research Article

Gardiner, S. J., & Begg, E. J. (2005). Pharmacogenetic testing for drug metabolizing enzymes: Is it happening in practice? Pharmacogenetics & Genomics, 15, 365-369.

Journal - Research Article

Gardiner, S. J., Begg, E. J., Zhang, M., & Hughes, R. C. (2005). Transfer of rofecoxib into human milk. European Journal of Clinical Pharmacology, 61(5-6), 405-408.

Journal - Research Article

Gardiner, S. J., & Begg, E. J. (2004). Genotyping for drug-metabolizing enzymes: Does the promise meet the reality? Pharmacogenomics, 5(8), 1033-1036. Future Medicine.

Journal - Research Article

Ilett, K. F., Hackett, L. P., Kristensen, J. H., Vaddadi, K. S., Gardiner, S. J., & Begg, E. J. (2004). Transfer of risperidone and 9-hydroxyrisperidone into human milk. Annals of Pharmacotherapy, 38, 273-276.

Journal - Research Article

Zhang, M., Moore, G. A., Gardiner, S. J., & Begg, E. J. (2004). Determination of rofecoxib in human plasma and breast milk by high-performance liquid chromatographic assay. Journal of Chromatography B, 807, 217-221. Elsevier.

Journal - Research Article

Gardiner, S. J., Kirkpatrick, C., Begg, E. J., Zhang, M., Moore, M. P., & Saville, D. J. (2003). Transfer of metformin into human milk. Clinical Pharmacology & Therapeutics, 73, 71-77.

Journal - Research Article

Gardiner, S. J., Kristensen, J. H., Begg, E. J., Hackett, L. P., Wilson, D. A., Ilett, K., … Rampono, J. (2003). Transfer of olanzapine into breast milk, calculation of infant drug dose, and effect on breast-fed infants. American Journal of Psychiatry, 160, 1428-1431.

Journal - Research Article

Gardiner, S. J., Begg, E. J., & Robinson, B. A. (2002). The effect of dihydropyrimidine dehydrogenase deficiency on outcomes with fluorouracil. Adverse Drug Reactions & Toxicological Reviews, 21(1-2), 1-16.

Journal - Research Article

Zhang, M., Moore, G. A., Lever, M., Gardiner, S. J., Kirkpatrick, C. M. J., & Begg, E. J. (2002). Rapid and simple high-performance liquid chromatographic assay for the determination of metformin in human plasma and breast milk. Journal of Chromatography B, 766(1), 175-179.

Journal - Research Article

Begg, E. J., Robson, R. A., Gardiner, S. J., Hudson, L. J., Reece, P. A., Olson, S. C., … Sedman, A. J. (2001). Quinapril and its metabolite quinaprilat in human milk. British Journal of Clinical Pharmacology, 51, 478-481.

Journal - Research Article

Gardiner, S. J., Kirkpatrick, C. M. J., & Begg, E. J. (2001). Fifteen years of drug information in Christchurch Hospital. New Zealand Medical Journal, 114, 393-395.

Journal - Research Article

Gardiner, S. J., Begg, E. J., Barclay, M. L., & Kirkpatrick, C. M. J. (2000). Genetic polymorphism and outcomes with azathioprine and 6-mercaptopurine. Adverse Drug Reactions & Toxicological Reviews, 19(4), 293-312.

Journal - Research Article

Gardiner, S. J., Kirkpatrick, C., & Begg, E. J. (1998). An audit of the drug information service at Christchurch Hospital. Proceedings of ASCEPT, 5, 113.

Journal - Research Article

Drennan, P. G., Begg, E. J., Gardiner, S. J., Kirkpatrick, C. M. J., & Chambers, S. T. (2019). The dosing and monitoring of vancomycin: What is the best way forward? International Journal of Antimicrobial Agents, 53, 401-407. doi: 10.1016/j.ijantimicag.2018.12.014

Journal - Research Other

Gardiner, S. J., Kirkpatrick, C. M. J., Zhang, M., & Begg, E. J. (2008). Cimetidine does not appear to influence the distribution of metformin into human milk [Letter to the editor]. British Journal of Clinical Pharmacology, 66(4), 564-565. doi: 10.1111/j.1365-2125.2008.03190.x

Journal - Research Other

Gardiner, S. J., Begg, E. J., Sau, A., Marinaki, A., Gearry, R. B., & Barclay, M. L. (2007). Thiopurine treatment in inflammatory bowel disease [Letter to the editor]. Clinical Pharmacokinetics, 46(9), 803-804.

Journal - Research Other

Gardiner, S. J., Gearry, R. B., Roberts, R. L., Zhang, M., Barclay, M. L., & Begg, E. J. (2007). Breast-feeding during maternal use of azathioprine [Comment]. Annals of Pharmacotherapy, 41(4), 719-720.

Journal - Research Other

Doogue, M. P., Gardiner, S. J., & Begg, E. J. (2004). Comment: Prediction of milk/plasma concentration ratio of drugs [Letter]. Annals of Pharmacotherapy, 38, 174-175.

Journal - Research Other

Doogue, M. P., Gardiner, S. J., & Begg, E. J. (2004). Comment: Prediction of milk/plasma concentration ratio of drugs. Annals of Pharmacotherapy, 38(1), 174-175.

Journal - Research Other

Gardiner, S. J., Begg, E. J., Kirkpatrick, C. M. J., & Buckham, R. B. (2004). Metformin therapy and diabetes in pregnancy [Letter to the editor]. Medical Journal of Australia, 181(3), 174-175.

Journal - Research Other

Gearry, R., Barclay, M., Gardiner, S., & Zhang, M. (2003). 6-thioguanine nucleotides and thiopurine methyltransferase activity: Important factors determining response to treatment and incidence of adverse effects from azathioprine and 6-MP [Letter]. New Zealand Medical Journal, 116(1178). Retrieved from http://journal.nzma.org.nz/journal/116-1178/531/content.pdf

Journal - Research Other

Begg, E., Sidwell, A., Gardiner, S., Nicholls, G., & Scott, R. (2003). The sorry saga of the statins in New Zealand: Pharmacopolitics versus patient care [Viewpoint]. New Zealand Medical Journal, 116(1170). Retrieved from http://journal.nzma.org.nz/journal/116-1170/360/content.pdf

Journal - Professional & Other Non-Research Articles

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