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Sharon Gardiner

Sharon Gardiner

Antimicrobial Pharmacist

BPharm(Hons), MClinPharm, PhD

Email sharon.gardiner@cdhb.health.nz

Sharon Gardiner is the antimicrobial pharmacist for CDHB, in a joint position between the departments of Clinical Pharmacology, Infectious Diseases and Pharmacy.

Her research interests include drug safety in breastfeeding, antibiotic dosing regimens and pharmacogenetics.

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Publications

Gardiner, S. J., Metcalf, S. C. L., Chin, P. K. L., Doogue, M. P., Dalton, S. C., & Chambers, S. T. (2018). Metronidazole stewardship initiative at Christchurch hospitals: Achievable with immediate benefits. New Zealand Medical Journal, 131(1473), 53-58. Retrieved from https://www.nzma.org.nz/journal

Gardiner, S. J., Drennan, P. G., Begg, R., Zhang, M., Green, J. K., Isenman, H. L., Everts, R. J., Chambers, S. T., & Begg, E. J. (2018). In healthy volunteers, taking flucloxacillin with food does not compromise effective plasma concentrations in most circumstances. PLoS ONE, 13(7), e0199370. doi: 10.1371/journal.pone.0199370

Chin, P. K. L., Drennan, P. G., Gardiner, S. J., Zhang, M., Dalton, S. C., Chambers, S. T., & Begg, E. J. (2018). Total flucloxacillin plasma concentrations poorly reflect unbound concentrations in hospitalised patients with Staphylococcus aureus bacteraemia. British Journal of Clinical Pharmacology. Advance online publication. doi: 10.1111/bcp.13673

Drennan, P. G., Begg, E. J., Gardiner, S. J., Kirkpatrick, C. M. J., & Chambers, S. T. (2018). The dosing and monitoring of vancomycin: What is the best way forward? International Journal of Antimicrobial Agents. Advance online publication. doi: 10.1016/j.ijantimicag.2018.12.014

Green, J. K., Gardiner, S. J., Clarke, S. L., Thompson, L., Metcalf, S. C. L., & Chambers, S. T. (2018). Antimicrobial stewardship practice in New Zealand's rural hospitals. New Zealand Medical Journal, 131(1481), 16-26. Retrieved from https://www.nzma.org.nz/journal

Edited Book - Other

Begg, E., Barclay, M., Vella-Brincat, J., Gardiner, S. J., Doogue, M., McDermott, L., … Chambers, S., & Murdoch, D. (Eds.). (2004). Preferred Medicines List (8th ed.). Christchurch: The Caxton Press, 172p.

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Chapter in Book - Research

Gardiner, S. J., Kirkpatrick, C. M. J., & Begg, E. J. (2015). Lactation and contamination of breast milk with Xenobiotics. In M. J. Caplan (Ed.), Reference module in biomedical sciences. Elsevier. doi: 10.1016/B978-0-12-801238-3.02154-1

Begg, E. J., Gardiner, S. J., & Kirkpatrick, C. M. J. (2010). Lactation and contamination of breast milk with xenobiotics. In C. A. McQueen (Ed.), Comprehensive toxicology. (2nd ed.) (pp. 445-455). Oxford, UK: Elsevier.

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Chapter in Book - Other

Gardiner, S. J., & Woods, D. J. (2007). Drugs in pregnancy and lactation. In R. Walker & C. Whittlesea (Eds.), Clinical pharmacy and therapeutics. (4th ed.) (pp. 681-690). Edinburgh, Scotland: Churchill Livingstone.

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Journal - Research Article

Gardiner, S. J., Metcalf, S. C. L., Chin, P. K. L., Doogue, M. P., Dalton, S. C., & Chambers, S. T. (2018). Metronidazole stewardship initiative at Christchurch hospitals: Achievable with immediate benefits. New Zealand Medical Journal, 131(1473), 53-58. Retrieved from https://www.nzma.org.nz/journal

Green, J. K., Gardiner, S. J., Clarke, S. L., Thompson, L., Metcalf, S. C. L., & Chambers, S. T. (2018). Antimicrobial stewardship practice in New Zealand's rural hospitals. New Zealand Medical Journal, 131(1481), 16-26. Retrieved from https://www.nzma.org.nz/journal

Drennan, P. G., Begg, E. J., Gardiner, S. J., Kirkpatrick, C. M. J., & Chambers, S. T. (2018). The dosing and monitoring of vancomycin: What is the best way forward? International Journal of Antimicrobial Agents. Advance online publication. doi: 10.1016/j.ijantimicag.2018.12.014

Chin, P. K. L., Drennan, P. G., Gardiner, S. J., Zhang, M., Dalton, S. C., Chambers, S. T., & Begg, E. J. (2018). Total flucloxacillin plasma concentrations poorly reflect unbound concentrations in hospitalised patients with Staphylococcus aureus bacteraemia. British Journal of Clinical Pharmacology. Advance online publication. doi: 10.1111/bcp.13673

Gardiner, S. J., Drennan, P. G., Begg, R., Zhang, M., Green, J. K., Isenman, H. L., Everts, R. J., Chambers, S. T., & Begg, E. J. (2018). In healthy volunteers, taking flucloxacillin with food does not compromise effective plasma concentrations in most circumstances. PLoS ONE, 13(7), e0199370. doi: 10.1371/journal.pone.0199370

Gardiner, S. J., Pryer, J. A., & Duffy, E. J. (2017). Survey of antimicrobial stewardship practices in public hospitals in New Zealand district health boards. New Zealand Medical Journal, 130(1458), 27-41. Retrieved from http://www.nzma.org.nz/journal

Gardiner, S. J., Gearry, R. B., Burt, M. J., Chalmers-Watson, T., Chapman, B. A., Ross, A. G., Stedman, C. A. M., … Barclay, M. L. (2011). Allopurinol might improve response to azathioprine and 6-mercaptopurine by correcting an unfavorable metabolite ratio. Journal of Gastroenterology & Hepatology, 26(1), 49-54. doi: 10.1111/j.1440-1746.2010.06489.x

Sharp, C. F., Gardiner, S. J., Jensen, B. P., Roberts, R. L., Troughton, R. W., Lainchbury, J. G., & Begg, E. J. (2009). CYP2D6 genotype and its relationship with metoprolol dose, concentrations and effect in patients with systolic heart failure. Pharmacogenomics Journal, 9(3), 175-184. doi: 10.1038/tpj.2009.9

Gardiner, S. J., Gearry, R. B., Burt, M. J., Ding, S. L., & Barclay, M. L. (2008). Severe hepatotoxicity with high 6-methylmercaptopurine nucleotide concentrations after thiopurine dose escalation due to low 6-thioguanine nucleotides. European Journal of Gastroenterology & Hepatology, 20(12), 1238-1242. doi: 10.1097/MEG.0b013e3282ffda37

Jensen, B. P., Sharp, C. F., Gardiner, S. J., & Begg, E. J. (2008). Development and validation of a stereoselective liquid chromatography-tandem mass spectrometry assay for quantification of S- and R-metoprolol in human plasma. Journal of Chromatography B, 865(1-2), 48-54. doi: 10.1016/j.jchromb.2008.02.006

Gardiner, S. J., Gearry, R. B., Begg, E. J., Zhang, M., & Barclay, M. L. (2008). Thiopurine dose in intermediate and normal metabolizers of thiopurine methyltransferase may differ three-fold. Clinical Gastroenterology & Hepatology, 6(6), 654-660. doi: 10.1016/j.cgh.2008.02.032

Gardiner, S. J., Gearry, R. B., Roberts, R. L., Zhang, M., Barclay, M. L., & Begg, E. J. (2006). Exposure to thiopurine drugs through breast milk is low based on metabolite concentrations in mother-infant pairs. British Journal of Clinical Pharmacology, 62(4), 453-456.

Zhang, M., Moore, G. A., Gardiner, S. J., & Begg, E. J. (2006). Determination of celecoxib in human plasma and breast milk by high-performance liquid chromatographic assay. Journal of Chromatography B, 830(2), 245-248. doi: 10.1016/j.jchromb.2005.10.048

Gardiner, S. J., Doogue, M. P., Zhang, M., & Begg, E. J. (2006). Quantification of infant exposure to celecoxib through breast milk. British Journal of Clinical Pharmacology, 61(1), 101-104. doi: 10.1111/j.1365-2125.2005.02520.x

Gardiner, S. J., Gearry, R. B., Barclay, M. L., & Begg, E. J. (2006). Two cases of thiopurine methyltransferase (TPMT) deficiency: A lucky save and a near miss with azathioprine. British Journal of Clinical Pharmacology, 62(4), 473-476. doi: 10.1111/j.1365-2125.2005.02474.x

Gardiner, S. J., & Begg, E. J. (2006). Breastfeeding during tacrolimus therapy. Obstetrics & Gynecology, 107(2, Part 2, Suppl.), 453-455.

Hughes, R. C., Gardiner, S. J., Begg, E. J., & Zhang, M. (2006). Effect of pregnancy on the pharmacokinetics of metformin. Diabetic Medicine, 23(3), 323-326. doi: 10.1111/j.1464-5491.2005.01769.x

Gardiner, S. J., & Begg, E. J. (2006). Pharmacogenetics, drug-metabolizing enzymes, and clinical practice. Pharmacological Reviews, 58(3), 521-590.

Priest, V. L., Begg, E. J., Gardiner, S. J., Frampton, C. M., Gearry, R. B., Barclay, M. L., Clark, D. W., & Hansen, P. (2006). Pharmacoeconomic analyses of azathioprine, methotrexate and prospective pharmacogenetic testing for the management of inflammatory bowel disease. Pharmacoeconomics, 24(8), 767-781.

Gardiner, S. J., Begg, E. J., Zhang, M., & Hughes, R. C. (2005). Transfer of rofecoxib into human milk. European Journal of Clinical Pharmacology, 61(5-6), 405-408.

Gardiner, S. J., & Begg, E. J. (2005). Pharmacogenetic testing for drug metabolizing enzymes: Is it happening in practice? Pharmacogenetics & Genomics, 15, 365-369.

Ilett, K. F., Hackett, L. P., Kristensen, J. H., Vaddadi, K. S., Gardiner, S. J., & Begg, E. J. (2004). Transfer of risperidone and 9-hydroxyrisperidone into human milk. Annals of Pharmacotherapy, 38, 273-276.

Zhang, M., Moore, G. A., Gardiner, S. J., & Begg, E. J. (2004). Determination of rofecoxib in human plasma and breast milk by high-performance liquid chromatographic assay. Journal of Chromatography B, 807, 217-221. Elsevier.

Gardiner, S. J., & Begg, E. J. (2004). Genotyping for drug-metabolizing enzymes: Does the promise meet the reality? Pharmacogenomics, 5(8), 1033-1036. Future Medicine.

Gardiner, S. J., Kirkpatrick, C., Begg, E. J., Zhang, M., Moore, M. P., & Saville, D. J. (2003). Transfer of metformin into human milk. Clinical Pharmacology & Therapeutics, 73, 71-77.

Gardiner, S. J., Kristensen, J. H., Begg, E. J., Hackett, L. P., Wilson, D. A., Ilett, K., … Rampono, J. (2003). Transfer of olanzapine into breast milk, calculation of infant drug dose, and effect on breast-fed infants. American Journal of Psychiatry, 160, 1428-1431.

Zhang, M., Moore, G. A., Lever, M., Gardiner, S. J., Kirkpatrick, C. M. J., & Begg, E. J. (2002). Rapid and simple high-performance liquid chromatographic assay for the determination of metformin in human plasma and breast milk. Journal of Chromatography B, 766(1), 175-179.

Gardiner, S. J., Begg, E. J., & Robinson, B. A. (2002). The effect of dihydropyrimidine dehydrogenase deficiency on outcomes with fluorouracil. Adverse Drug Reactions & Toxicological Reviews, 21(1-2), 1-16.

Gardiner, S. J., Kirkpatrick, C. M. J., & Begg, E. J. (2001). Fifteen years of drug information in Christchurch Hospital. New Zealand Medical Journal, 114, 393-395.

Begg, E. J., Robson, R. A., Gardiner, S. J., Hudson, L. J., Reece, P. A., Olson, S. C., … Sedman, A. J. (2001). Quinapril and its metabolite quinaprilat in human milk. British Journal of Clinical Pharmacology, 51, 478-481.

Gardiner, S. J., Begg, E. J., Barclay, M. L., & Kirkpatrick, C. M. J. (2000). Genetic polymorphism and outcomes with azathioprine and 6-mercaptopurine. Adverse Drug Reactions & Toxicological Reviews, 19(4), 293-312.

Gardiner, S. J., Kirkpatrick, C., & Begg, E. J. (1998). An audit of the drug information service at Christchurch Hospital. Proceedings of ASCEPT, 5, 113.

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Journal - Research Other

Gardiner, S. J., Kirkpatrick, C. M. J., Zhang, M., & Begg, E. J. (2008). Cimetidine does not appear to influence the distribution of metformin into human milk [Letter to the editor]. British Journal of Clinical Pharmacology, 66(4), 564-565. doi: 10.1111/j.1365-2125.2008.03190.x

Gardiner, S. J., Begg, E. J., Sau, A., Marinaki, A., Gearry, R. B., & Barclay, M. L. (2007). Thiopurine treatment in inflammatory bowel disease [Letter to the editor]. Clinical Pharmacokinetics, 46(9), 803-804.

Gardiner, S. J., Gearry, R. B., Roberts, R. L., Zhang, M., Barclay, M. L., & Begg, E. J. (2007). Breast-feeding during maternal use of azathioprine [Comment]. Annals of Pharmacotherapy, 41(4), 719-720.

Doogue, M. P., Gardiner, S. J., & Begg, E. J. (2004). Comment: Prediction of milk/plasma concentration ratio of drugs [Letter]. Annals of Pharmacotherapy, 38, 174-175.

Doogue, M. P., Gardiner, S. J., & Begg, E. J. (2004). Comment: Prediction of milk/plasma concentration ratio of drugs. Annals of Pharmacotherapy, 38(1), 174-175.

Gardiner, S. J., Begg, E. J., Kirkpatrick, C. M. J., & Buckham, R. B. (2004). Metformin therapy and diabetes in pregnancy [Letter to the editor]. Medical Journal of Australia, 181(3), 174-175.

Gearry, R., Barclay, M., Gardiner, S., & Zhang, M. (2003). 6-thioguanine nucleotides and thiopurine methyltransferase activity: Important factors determining response to treatment and incidence of adverse effects from azathioprine and 6-MP [Letter]. New Zealand Medical Journal, 116(1178). Retrieved from http://journal.nzma.org.nz/journal/116-1178/531/content.pdf

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Journal - Professional & Other Non-Research Articles

Begg, E., Sidwell, A., Gardiner, S., Nicholls, G., & Scott, R. (2003). The sorry saga of the statins in New Zealand: Pharmacopolitics versus patient care [Viewpoint]. New Zealand Medical Journal, 116(1170). Retrieved from http://journal.nzma.org.nz/journal/116-1170/360/content.pdf

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Conference Contribution - Published proceedings: Abstract

Chuah, Q., Chin, P., Hamilton, N., Gardiner, S., Strother, M., Dalton, S., Metcalf, S., & Doogue, M. (2017). Using electronic prescribing data to direct antimicrobial stewardship. Proceedings of the Health Informatics New Zealand (HiNZ) Conference. (pp. 107). Retrieved from http://www.hinz.org.nz/

Hamilton, N., Chuah, Q., Chin, P., & Gardiner, S. (2017). Real-time review of electronic prescribing of restricted antimicrobials: A pilot of a new antimicrobial stewardship initiative for Christchurch Hospital. Proceedings of the Australasian Pharmaceutical Science Association and the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (APSA-ASCEPT) Joint Scientific Meeting. (pp. 79). Retrieved from http://www.asceptasm.com/

Everts, R., Chambers, S., Begg, E., Elvy, J., Gardiner, S., Mayer, H., & Turnidge, J. (2016). Pilot study of flucloxacillin and probenecid twice daily versus flucloxacillin four times daily for acute bacterial skin infections. Proceedings of the Australasian Society for Infectious Diseases New Zealand Branch Annual Scientific Meeting. Retrieved from https://www.asid.net.au/

Ghoreishi, N., Graham, T., Gardiner, S., & Walls, T. (2016). Antimicrobial use in children at a tertiary teaching hospital in New Zealand. International Journal of Infectious Diseases, 45(Suppl. 1), (pp. 120-121). doi: 10.1016/j.ijid.2016.02.302

Gardiner, S. J., Drennan, P. G., Begg, R., Zhang, M., Green, J. K., Isenman, H. L., Everts, R. J., Chambers, S. T., & Begg, E. J. (2016). Taking flucloxacillin with food does not compromise effective plasma concentrations in healthy volunteers. Proceedings of the Australasian Society for Infectious Diseases New Zealand Branch Annual Scientific Meeting. Retrieved from https://www.asid.net.au/

Barclay, M. L., Gardiner, S. J., Gearry, R. B., Burt, M. J., Chalmers-Watson, T., Chapman, B. A., … Stedman, C. A. M. (2008). Allopurinol may improve response to azathioprine and 6-mercaptopurine by correcting an unfavorable metabolite ratio. Journal of Gastroenterology and Hepatology. 23(Suppl. 4), (pp. A194). [Abstract]

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