Antimicrobial Pharmacist
BPharm(Hons), MClinPharm, PhD
Email sharon.gardiner@cdhb.health.nz
Sharon Gardiner is the antimicrobial pharmacist for CDHB, in a joint position between the departments of Clinical Pharmacology, Infectious Diseases and Pharmacy.
Her research interests include drug safety in breastfeeding, antibiotic dosing regimens and pharmacogenetics.
Publications
Hagedoorn, N. N., Al-Busaidi, I., Bridgford, P., Gardiner, S. J., Walls, T., & Hudson, B. (2023). Longitudinal trends in community antibiotic consumption in the Waitaha Canterbury Region of Aotearoa New Zealand over 10 years (2012-2021): An observational study. New Zealand Medical Journal/Te ara tika o te hauora hapori, 136(1571), 49-64. Retrieved from https://journal.nzma.org.nz/
Pairman, L., Chin, P., Gardiner, S., & Doogue, M. (2022, August-September). The effect of mandatory prescription indications for antibacterials. Verbal presentation at the Australasian Society of Clinical & Experimental Pharmacologists & Toxicologists (ASCEPT) NZ Annual Scientific Meeting, Queenstown, New Zealand.
Gardiner, S. J., Duffy, E. J., Chambers, S. T., Thomas, M. G., Addidle, M., Arnold, B., … Balm, M. N. D., … Berger, S., … Birch, M., Blackmore, T. K., Bloomfield, M., … Bupha-Intr, O., … Campbell, C., Chin, P. K. L., Dalton, S. C., … Douglas, N. M., … Elvy, J., Everts, R., … Hudson, B., … Isenman, H., Issa, M., Kelly, M. J., Li, C., … Maze, M., Metcalf, S. C. L., McCall, C., Murdoch, D., … Pithie, A., Raymond, N., … Ussher, J. E., … Walls, T., & Yew, H. S. (2021). Antimicrobial stewardship in human healthcare in Aotearoa New Zealand: Urgent call for national leadership and co-ordinated efforts to preserve antimicrobial effectiveness. New Zealand Medical Journal, 134(1544), 113-128. Retrieved from https://www.nzma.org.nz/journal
Everts, R. J., Gardiner, S. J., Zhang, M., Begg, R., Chambers, S. T., Turnidge, J., & Begg, E. J. (2021). Probenecid effects on cephalexin pharmacokinetics and pharmacodynamics in healthy volunteers. Journal of Infection, 83, 182-189. doi: 10.1016/j.jinf.2021.05.037
Drennan, P. G., Green, J. K., Gardiner, S. J., Metcalf, S. C. L., Kirkpatrick, C. M. J., Everts, R. J., Zhang, M., & Chambers, S. T. (2021). Population pharmacokinetics of free flucloxacillin in patients treated with oral flucloxacillin plus probenecid. British Journal of Clinical Pharmacology, 87, 4684-4693. doi: 10.1111/bcp.14887
Begg, E., Barclay, M., Vella-Brincat, J., Gardiner, S. J., Doogue, M., McDermott, L., … Chambers, S., & Murdoch, D. (Eds.). (2004). Preferred Medicines List (8th ed.). Christchurch: The Caxton Press, 172p.
Edited Book - Other
Gardiner, S. J., Kirkpatrick, C. M. J., & Begg, E. J. (2015). Lactation and contamination of breast milk with Xenobiotics. In M. J. Caplan (Ed.), Reference module in biomedical sciences. Elsevier. doi: 10.1016/B978-0-12-801238-3.02154-1
Chapter in Book - Research
Begg, E. J., Gardiner, S. J., & Kirkpatrick, C. M. J. (2010). Lactation and contamination of breast milk with xenobiotics. In C. A. McQueen (Ed.), Comprehensive toxicology. (2nd ed.) (pp. 445-455). Oxford, UK: Elsevier.
Chapter in Book - Research
Gardiner, S. J., & Woods, D. J. (2007). Drugs in pregnancy and lactation. In R. Walker & C. Whittlesea (Eds.), Clinical pharmacy and therapeutics. (4th ed.) (pp. 681-690). Edinburgh, Scotland: Churchill Livingstone.
Chapter in Book - Other
Hagedoorn, N. N., Al-Busaidi, I., Bridgford, P., Gardiner, S. J., Walls, T., & Hudson, B. (2023). Longitudinal trends in community antibiotic consumption in the Waitaha Canterbury Region of Aotearoa New Zealand over 10 years (2012-2021): An observational study. New Zealand Medical Journal/Te ara tika o te hauora hapori, 136(1571), 49-64. Retrieved from https://journal.nzma.org.nz/
Journal - Research Article
Drennan, P. G., Green, J. K., Gardiner, S. J., Metcalf, S. C. L., Kirkpatrick, C. M. J., Everts, R. J., Zhang, M., & Chambers, S. T. (2021). Population pharmacokinetics of free flucloxacillin in patients treated with oral flucloxacillin plus probenecid. British Journal of Clinical Pharmacology, 87, 4684-4693. doi: 10.1111/bcp.14887
Journal - Research Article
Everts, R. J., Gardiner, S. J., Zhang, M., Begg, R., Chambers, S. T., Turnidge, J., & Begg, E. J. (2021). Probenecid effects on cephalexin pharmacokinetics and pharmacodynamics in healthy volunteers. Journal of Infection, 83, 182-189. doi: 10.1016/j.jinf.2021.05.037
Journal - Research Article
Chambers, S. T., Long, M., Gardiner, S. J., Chin, P. K. L., Yi, M., Dalton, S. C., … Metcalf, S. C. L. (2020). Determinants of vancomycin nephrotoxicity when administered to outpatients as a continuous 24-hour infusion. International Journal of Antimicrobial Agents, 55, 105972. doi: 10.1016/j.ijantimicag.2020.105972
Journal - Research Article
Everts, R. J., Begg, R., Gardiner, S. J., Zhang, M., Turnidge, J., Chambers, S. T., & Begg, E. J. (2020). Probenecid and food effects on flucloxacillin pharmacokinetics and pharmacodynamics in healthy volunteers. Journal of Infection, 80, 42-53. doi: 10.1016/j.jinf.2019.09.004
Journal - Research Article
Gardiner, S. J., Basevi, A. B., Hamilton, N. L., Metcalf, S. C. L., Chambers, S. T., Withington, S. G., Chin, P. K., Freeman, J. T., Dalton, S. C., on behalf of the Canterbury District Health Board Antimicrobial Stewardship Committee. (2020). Point prevalence surveys of antimicrobial use in adult inpatients at Canterbury District Health Board hospitals. New Zealand Medical Journal, 133(1525), 18-33. Retrieved from https://www.nzma.org.nz/journal
Journal - Research Article
Gardiner, S. J., Metcalf, S. C. L., Werno, A., Doogue, M. P., Chambers, S. T., on behalf of the Canterbury District Health Board Antimicrobial Stewardship Committee. (2020). A persuasive approach to antimicrobial stewardship in Christchurch hospitals produced a sustained decrease in intravenous clarithromycin dosing and expenditure via a switch to azithromycin orally. New Zealand Medical Journal, 133(1512), 22-30. Retrieved from https://www.nzma.org.nz/journal
Journal - Research Article
Chin, P. K. L., Drennan, P. G., Gardiner, S. J., Zhang, M., Dalton, S. C., Chambers, S. T., & Begg, E. J. (2018). Total flucloxacillin plasma concentrations poorly reflect unbound concentrations in hospitalised patients with Staphylococcus aureus bacteraemia. British Journal of Clinical Pharmacology, 84(10), 2311-2316. doi: 10.1111/bcp.13673
Journal - Research Article
Gardiner, S. J., Drennan, P. G., Begg, R., Zhang, M., Green, J. K., Isenman, H. L., Everts, R. J., Chambers, S. T., & Begg, E. J. (2018). In healthy volunteers, taking flucloxacillin with food does not compromise effective plasma concentrations in most circumstances. PLoS ONE, 13(7), e0199370. doi: 10.1371/journal.pone.0199370
Journal - Research Article
Gardiner, S. J., Metcalf, S. C. L., Chin, P. K. L., Doogue, M. P., Dalton, S. C., & Chambers, S. T. (2018). Metronidazole stewardship initiative at Christchurch hospitals: Achievable with immediate benefits. New Zealand Medical Journal, 131(1473), 53-58. Retrieved from https://www.nzma.org.nz/journal
Journal - Research Article
Green, J. K., Gardiner, S. J., Clarke, S. L., Thompson, L., Metcalf, S. C. L., & Chambers, S. T. (2018). Antimicrobial stewardship practice in New Zealand's rural hospitals. New Zealand Medical Journal, 131(1481), 16-26. Retrieved from https://www.nzma.org.nz/journal
Journal - Research Article
Gardiner, S. J., Pryer, J. A., & Duffy, E. J. (2017). Survey of antimicrobial stewardship practices in public hospitals in New Zealand district health boards. New Zealand Medical Journal, 130(1458), 27-41. Retrieved from http://www.nzma.org.nz/journal
Journal - Research Article
Gardiner, S. J., Gearry, R. B., Burt, M. J., Chalmers-Watson, T., Chapman, B. A., Ross, A. G., Stedman, C. A. M., … Barclay, M. L. (2011). Allopurinol might improve response to azathioprine and 6-mercaptopurine by correcting an unfavorable metabolite ratio. Journal of Gastroenterology & Hepatology, 26(1), 49-54. doi: 10.1111/j.1440-1746.2010.06489.x
Journal - Research Article
Sharp, C. F., Gardiner, S. J., Jensen, B. P., Roberts, R. L., Troughton, R. W., Lainchbury, J. G., & Begg, E. J. (2009). CYP2D6 genotype and its relationship with metoprolol dose, concentrations and effect in patients with systolic heart failure. Pharmacogenomics Journal, 9(3), 175-184. doi: 10.1038/tpj.2009.9
Journal - Research Article
Gardiner, S. J., Gearry, R. B., Begg, E. J., Zhang, M., & Barclay, M. L. (2008). Thiopurine dose in intermediate and normal metabolizers of thiopurine methyltransferase may differ three-fold. Clinical Gastroenterology & Hepatology, 6(6), 654-660. doi: 10.1016/j.cgh.2008.02.032
Journal - Research Article
Gardiner, S. J., Gearry, R. B., Burt, M. J., Ding, S. L., & Barclay, M. L. (2008). Severe hepatotoxicity with high 6-methylmercaptopurine nucleotide concentrations after thiopurine dose escalation due to low 6-thioguanine nucleotides. European Journal of Gastroenterology & Hepatology, 20(12), 1238-1242. doi: 10.1097/MEG.0b013e3282ffda37
Journal - Research Article
Jensen, B. P., Sharp, C. F., Gardiner, S. J., & Begg, E. J. (2008). Development and validation of a stereoselective liquid chromatography-tandem mass spectrometry assay for quantification of S- and R-metoprolol in human plasma. Journal of Chromatography B, 865(1-2), 48-54. doi: 10.1016/j.jchromb.2008.02.006
Journal - Research Article
Gardiner, S. J., & Begg, E. J. (2006). Breastfeeding during tacrolimus therapy. Obstetrics & Gynecology, 107(2, Part 2, Suppl.), 453-455.
Journal - Research Article
Gardiner, S. J., & Begg, E. J. (2006). Pharmacogenetics, drug-metabolizing enzymes, and clinical practice. Pharmacological Reviews, 58(3), 521-590.
Journal - Research Article
Gardiner, S. J., Doogue, M. P., Zhang, M., & Begg, E. J. (2006). Quantification of infant exposure to celecoxib through breast milk. British Journal of Clinical Pharmacology, 61(1), 101-104. doi: 10.1111/j.1365-2125.2005.02520.x
Journal - Research Article
Gardiner, S. J., Gearry, R. B., Barclay, M. L., & Begg, E. J. (2006). Two cases of thiopurine methyltransferase (TPMT) deficiency: A lucky save and a near miss with azathioprine. British Journal of Clinical Pharmacology, 62(4), 473-476. doi: 10.1111/j.1365-2125.2005.02474.x
Journal - Research Article
Gardiner, S. J., Gearry, R. B., Roberts, R. L., Zhang, M., Barclay, M. L., & Begg, E. J. (2006). Exposure to thiopurine drugs through breast milk is low based on metabolite concentrations in mother-infant pairs. British Journal of Clinical Pharmacology, 62(4), 453-456.
Journal - Research Article
Hughes, R. C., Gardiner, S. J., Begg, E. J., & Zhang, M. (2006). Effect of pregnancy on the pharmacokinetics of metformin. Diabetic Medicine, 23(3), 323-326. doi: 10.1111/j.1464-5491.2005.01769.x
Journal - Research Article
Priest, V. L., Begg, E. J., Gardiner, S. J., Frampton, C. M., Gearry, R. B., Barclay, M. L., Clark, D. W., & Hansen, P. (2006). Pharmacoeconomic analyses of azathioprine, methotrexate and prospective pharmacogenetic testing for the management of inflammatory bowel disease. Pharmacoeconomics, 24(8), 767-781.
Journal - Research Article
Zhang, M., Moore, G. A., Gardiner, S. J., & Begg, E. J. (2006). Determination of celecoxib in human plasma and breast milk by high-performance liquid chromatographic assay. Journal of Chromatography B, 830(2), 245-248. doi: 10.1016/j.jchromb.2005.10.048
Journal - Research Article
Gardiner, S. J., & Begg, E. J. (2005). Pharmacogenetic testing for drug metabolizing enzymes: Is it happening in practice? Pharmacogenetics & Genomics, 15, 365-369.
Journal - Research Article
Gardiner, S. J., Begg, E. J., Zhang, M., & Hughes, R. C. (2005). Transfer of rofecoxib into human milk. European Journal of Clinical Pharmacology, 61(5-6), 405-408.
Journal - Research Article
Gardiner, S. J., & Begg, E. J. (2004). Genotyping for drug-metabolizing enzymes: Does the promise meet the reality? Pharmacogenomics, 5(8), 1033-1036. Future Medicine.
Journal - Research Article
Ilett, K. F., Hackett, L. P., Kristensen, J. H., Vaddadi, K. S., Gardiner, S. J., & Begg, E. J. (2004). Transfer of risperidone and 9-hydroxyrisperidone into human milk. Annals of Pharmacotherapy, 38, 273-276.
Journal - Research Article
Zhang, M., Moore, G. A., Gardiner, S. J., & Begg, E. J. (2004). Determination of rofecoxib in human plasma and breast milk by high-performance liquid chromatographic assay. Journal of Chromatography B, 807, 217-221. Elsevier.
Journal - Research Article
Gardiner, S. J., Kirkpatrick, C., Begg, E. J., Zhang, M., Moore, M. P., & Saville, D. J. (2003). Transfer of metformin into human milk. Clinical Pharmacology & Therapeutics, 73, 71-77.
Journal - Research Article
Gardiner, S. J., Kristensen, J. H., Begg, E. J., Hackett, L. P., Wilson, D. A., Ilett, K., … Rampono, J. (2003). Transfer of olanzapine into breast milk, calculation of infant drug dose, and effect on breast-fed infants. American Journal of Psychiatry, 160, 1428-1431.
Journal - Research Article
Gardiner, S. J., Begg, E. J., & Robinson, B. A. (2002). The effect of dihydropyrimidine dehydrogenase deficiency on outcomes with fluorouracil. Adverse Drug Reactions & Toxicological Reviews, 21(1-2), 1-16.
Journal - Research Article
Zhang, M., Moore, G. A., Lever, M., Gardiner, S. J., Kirkpatrick, C. M. J., & Begg, E. J. (2002). Rapid and simple high-performance liquid chromatographic assay for the determination of metformin in human plasma and breast milk. Journal of Chromatography B, 766(1), 175-179.
Journal - Research Article
Begg, E. J., Robson, R. A., Gardiner, S. J., Hudson, L. J., Reece, P. A., Olson, S. C., … Sedman, A. J. (2001). Quinapril and its metabolite quinaprilat in human milk. British Journal of Clinical Pharmacology, 51, 478-481.
Journal - Research Article
Gardiner, S. J., Kirkpatrick, C. M. J., & Begg, E. J. (2001). Fifteen years of drug information in Christchurch Hospital. New Zealand Medical Journal, 114, 393-395.
Journal - Research Article
Gardiner, S. J., Begg, E. J., Barclay, M. L., & Kirkpatrick, C. M. J. (2000). Genetic polymorphism and outcomes with azathioprine and 6-mercaptopurine. Adverse Drug Reactions & Toxicological Reviews, 19(4), 293-312.
Journal - Research Article
Gardiner, S. J., Kirkpatrick, C., & Begg, E. J. (1998). An audit of the drug information service at Christchurch Hospital. Proceedings of ASCEPT, 5, 113.
Journal - Research Article
Gardiner, S. J., Duffy, E. J., Chambers, S. T., Thomas, M. G., Addidle, M., Arnold, B., … Balm, M. N. D., … Berger, S., … Birch, M., Blackmore, T. K., Bloomfield, M., … Bupha-Intr, O., … Campbell, C., Chin, P. K. L., Dalton, S. C., … Douglas, N. M., … Elvy, J., Everts, R., … Hudson, B., … Isenman, H., Issa, M., Kelly, M. J., Li, C., … Maze, M., Metcalf, S. C. L., McCall, C., Murdoch, D., … Pithie, A., Raymond, N., … Ussher, J. E., … Walls, T., & Yew, H. S. (2021). Antimicrobial stewardship in human healthcare in Aotearoa New Zealand: Urgent call for national leadership and co-ordinated efforts to preserve antimicrobial effectiveness. New Zealand Medical Journal, 134(1544), 113-128. Retrieved from https://www.nzma.org.nz/journal
Journal - Research Other
Drennan, P. G., Begg, E. J., Gardiner, S. J., Kirkpatrick, C. M. J., & Chambers, S. T. (2019). The dosing and monitoring of vancomycin: What is the best way forward? International Journal of Antimicrobial Agents, 53, 401-407. doi: 10.1016/j.ijantimicag.2018.12.014
Journal - Research Other
Gardiner, S. J., Kirkpatrick, C. M. J., Zhang, M., & Begg, E. J. (2008). Cimetidine does not appear to influence the distribution of metformin into human milk [Letter to the editor]. British Journal of Clinical Pharmacology, 66(4), 564-565. doi: 10.1111/j.1365-2125.2008.03190.x
Journal - Research Other
Gardiner, S. J., Begg, E. J., Sau, A., Marinaki, A., Gearry, R. B., & Barclay, M. L. (2007). Thiopurine treatment in inflammatory bowel disease [Letter to the editor]. Clinical Pharmacokinetics, 46(9), 803-804.
Journal - Research Other
Gardiner, S. J., Gearry, R. B., Roberts, R. L., Zhang, M., Barclay, M. L., & Begg, E. J. (2007). Breast-feeding during maternal use of azathioprine [Comment]. Annals of Pharmacotherapy, 41(4), 719-720.
Journal - Research Other
Doogue, M. P., Gardiner, S. J., & Begg, E. J. (2004). Comment: Prediction of milk/plasma concentration ratio of drugs [Letter]. Annals of Pharmacotherapy, 38, 174-175.
Journal - Research Other
Doogue, M. P., Gardiner, S. J., & Begg, E. J. (2004). Comment: Prediction of milk/plasma concentration ratio of drugs. Annals of Pharmacotherapy, 38(1), 174-175.
Journal - Research Other
Gardiner, S. J., Begg, E. J., Kirkpatrick, C. M. J., & Buckham, R. B. (2004). Metformin therapy and diabetes in pregnancy [Letter to the editor]. Medical Journal of Australia, 181(3), 174-175.
Journal - Research Other