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Clinical Pharmacology Publications - 2008

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  • Tarrant KM, Barclay ML, Frampton CMA, Gearry RB. Perianal disease predicts changes in Crohn’s Disease phenotype – results of a population-based study of inflammatory bowel disease phenotype. Am J Gastroenterol 2008; 3082-93 [Abstract]
  • McKean A, Vella-Brincat JW, Begg EJ. Prescribing and monitoring clozapine in Christchurch. Aust Psychiatry 2008; 16(4), 263-7 [Abstract]
  • Dalrymple JM, Stamp LK, O’Donnell JL, Chapman PT, Zhang M, Barclay ML. Pharmacokinetics of oral methotrexate in patients with rheumatoid arthritis. Arthritis Rheumatol 2008; 58(11), 3299-308 [Abstract]
  • Begg EJ. Prescribing in pregnancy and lactation. Br J Clin Pharmacol 2008 65(5), 627-8 [Abstract]
  • Allegaert K, Vella-Brincat J, Verbesselt R, Devlieger R, Van Mieghem T. The impact of pregnancy on in vivo cefazolin protein binding saturability. Br J Clin Pharmacol 2008; 66(5), 732-3 [Abstract]
  • Sung EYY, Moore MP, Lunt H, Doogue MP, Zhang M and Begg EJ. Do thiazide diuretics alter the pharmacokinetics of metformin in patients with Type 2 diabetes already established on metformin? (Letter). Br J Clin Pharmacol 2008; 67(1), 130-1 [Abstract]
  • Gardiner SJ, Kirkpatrick CMJ, Zhang M, Begg EJ. Cimetidine does not appear to influence the distribution of metformin into human milk. Br J Clin Pharmacol 2008 66(4), 564-5 [Abstract]
  • Gardiner SJ, Gearry RB, Begg EJ, Zhang M, Barclay ML. Thiopurine dose in intermediate and normal metabolisers of thiopurine methyltransferase may differ 3-fold. Clin Gastroenterol Hepatol 2008; 6(6), 654-60 [Abstract]
  • Butler JM, Begg EJ. Free Drug Metabolic Clearance in Elderly People. Clin Pharmacokinet 2008; 47(5), 297-321 [Abstract]
  • Ferguson LR, Browning BL, Huebner C, Petermann I, Shelling AN, Demmers P, McCulloch A, Gearry RB, Barclay ML, Philpott M. Single nucleotide polymorphisms in human Paneth cell defensin A5 may confer susceptibility to inflammatory bowel disease in a New Zealand Caucasian population. Dig Liver Dis 2008; 40, 723-30 [Abstract]
  • Roberts RL, Gearry RB, Kennedy MA, Barclay ML. Beyond TPMT: genetic influences on thiopurine drug responses in inflammatory bowel disease. Per Med 2008; 5(3), 233-48 [Abstract]
  • Roberts RL, Hollis-Moffatt JE, Gearry RB, Barclay ML, et al. Confirmation of association of IRGM and NCF4 with ileal Crohn’s disease in a population-based cohort. Genes Immun 2008; 9, 561-5 [Abstract]
  • Jensen BP, Sharp CF, Gardiner SJ and Begg EJ. Development and validation of a stereoselective liquid chromatography-tandem mass spectrometry assay for quantification of S- and R-metoprolol in human plasma. J Chromatogr B 2008; 865, 48–54 [Abstract]
  • Barclay ML, Gardiner SJ, Gearry RB, Burt MJ, Chalmers-Watson T. Allopurinol may improve response to azathioprine and 6-mercaptopurine by correcting an unfavourable metabolite ratio. J Gastroenterol Hepatol 2008; 23, A194 [Abstract]
  • Browning BL, Annese V, Barclay ML, Bingham SA, Brand S, Büning C, Castro M, Cucchiara S, Dallapiccola B, Drummond H, Ferguson LR, Ferraris A, Fisher SA, Gearry RB, et al. Gender-stratified analysis of DLG5 R30Q in 4707 patients with Crohn disease and 4973 controls from 12 Caucasian cohorts. J Med Genet 2008;45(1), 36-42 [Abstract]
  • Ferguson LR, Han DY, Huebner C, Petermann I, Barclay ML, et al. Single nucleotide polymorphisms in IL4, OCTN1 and OCTN2 genes in association with IBD phenotypes in a Caucasian population in Canterbury, New Zealand. Open Gastroenterol J 2008; 2, 50-6 [Abstract]
  • Roberts RL, Gearry RB, Bland MV, Sies CW, George PM, Burt M, Marinaki AM, Arenas M, Barclay ML, Kennedy MA. Trinucleotide repeat variants in the promoter of the thiopurine S-methyltransferase gene of patients exhibiting ultra-high enzyme activity. Pharmacogenet Genomics 2008; 18(5), 434-8 [Abstract]
  • Gardiner SJ. Azathioprine/mercaptopurine. Reactions Weekly 2008; 1229(1), 7 [Abstract]
  • Ferguson LR, Huebner C, Petermann I, Barclay ML, et al. Single nucleotide polymorphism in the tumor necrosis factor-alpha gene affects IBD risk. World J Gastroenterol 2008; 14(29), 4652-61 [Abstract]
  • Begg EJ, Vella-Brincat JW, Robertshawe B. Paediatric and neonatal infections. Clin Infect Dis 2008; 46, 193-200 [Abstract]
  • Gardiner SJ, Gearry RB, Burt MJ, Ding SL, Barclay ML. Severe hepatotoxicity with high 6-methylmercaptopurine nucleotide concentrations after thiopurine dose escalation due to low 6-thioguanine nucleotides. Eur J Gastroenterol Hepatol 2008; 20(12), 1238-42 [Abstract]
  • Stamp LK, O’Donnell j, Chapman P, Zhang M, Frampton C, Barclay M. Methotrexate polyglutamates and disease activity in rheumatoid arthritis. Arthritis Rheumatol 2008; 58(9), S544 [No abstract]
  • Bird PA, Begg EJ. Rapid clearance of methylprednisolone after intratympanic application in humans. Comment on letter to the Editor in relation to the above. Otol Neurotol 2008 (in press) [No abstract]
  • Bentley RW, Keenan JI, Gearry RB, Kennedy MA, Barclay ML, Roberts RL. Incidence of Mycobacterium avium Subspecies paratuberculosis in a Population-Based Cohort of Patients With Crohn's Disease and Control Subjects. Am J Gastroenterol 2008 Mar 26 [Epub ahead of print]