Accessibility Skip to Global Navigation Skip to Local Navigation Skip to Content Skip to Search Skip to Site Map Menu

Professor Les Toop

Les Toop

Head of Department

MB ChB MD(Brist) MRCGP FRNZCGP

Email les.toop@otago.ac.nz
Tel +64 3 364 3604

Les is professor and has been head of the Department of General Practice since 1997.  He is involved in General Practice education and research at all levels.

Les has been in part-time urban general practice in Christchurch for 29 years and in addition to his clinical role, is involved in both undergraduate and postgraduate teaching.  

He is actively involved both in multidisciplinary clinical research and in health system redesign and is a long term advocate for the promotion of rational, effective and patient-centred care, delivered though strong interdisciplinary teamwork.

Les has been a vocal critic of misleading marketing, instead promoting access to evidence informed, independent health information for all.

He provides clinical and academic advice to the emerging national integration framework and has sat on many government advisory committees over two decades. He is currently on the medicines classification committee and on the GPNZ national executive.

Les is Chair of the Pegasus Health Charitable group of companies, one of the largest New Zealand primary health network organisations.  He was involved in setting and leading its unique interdisciplinary continuing education programme which has been running successfully for more than two decades and currently expanding throughout the country.  

He also sits on the alliance leadership team of the multi award winning Canterbury Clinical Network which recently was awarded the Prime Ministers supreme award for public service.

Les has had long involvement with the RNZCGP, sat on its national council for twenty some years and currently chairs its Research and Education Trust.

Current Research Interests

  • Inter professional education esp. around all aspects of prescribing and referred services and numerous investigator led RCTS to inform the same
  • Clinical variation
  • Antibiotic resistance
  • Clinical indicators
  • Integration and system redesign
  • Asthma 
  • Interdisciplinary teamwork 

Summer Student Supervision

2017-2018

Suli Tuitaupe
Topic: Understanding the ASH rates for Pacific children in Canterbury
Supervisor(s): Professor Les Toop and Deborah Callahan
Sponsor: Pegasus Health (Charitable) Trust

2016-17

Ga Hee Lee (Amy)
Topic: Understanding Canterbury's Pacific communities views about mental illness.
Supervisors: Professor Les Toop and Dr Lynley Cook
Sponsor: Pegasus Health (Charitable) Limited

2015-16

Tara Millar
Topic: Retrospective study of 50 patients with cellulitis treated under Acute Demand Management Service looking at duration of intravenous and oral antibiotics and time of switch between oral and intravenous
Supervisors: Dr Belinda van Gruting and Professor Les Toop
Sponsor: Pegasus Health (Charitable) Trust

2014-15

Sophie Bang
Topic: Developing Practice Managers: Understanding the General Practice Management Workforce
Supervisors: Leigh Aston and Professor Les Toop
Sponsor: Pegasus Health (Charitable) Ltd 

Rosa Leggat  
Topic: Understanding the Learning Needs of Community Physiotherapists
Supervisors: Charlotte Matthews and Professor Les Toop
Sponsor: Pegasus Health (Charitable) Ltd

2013-14

Ann Jun
Topic: Supporting patients in decision making
Supervisors: Prof Les Toop,  Andrew Richardson (Pegasus Health)
Sponsor: Pegasus Health

2012-13

Annelise Basevi 
Topic: Improving our clinical systems and care to help our patients have a better experience.
Supervisors: Dr Andrew Richardson, Professor Les Toop, Dr Paul Abernethy
Sponsor: Pegasus Health

2011-12

Amber-Jane Wood
Topic: Understanding the learning needs of community pharmacists.
Supervisors: Les Toop and Kelly Robertson
Sponsor: Partnership Health Canterbury

Rachael Stevenson
Topic: The Canterbury Methadone Maintenance Model of Care
Supervisors: Ian Sheerin, Les Toop, David Kerr
Sponsor: Pegasus Health

2010-11

Katie Jefferson
Topic: Exploring and understanding the learning needs of general practice administration support staff.
Supervisor: Les Toop
Sponsor: Partnership Health Canterbury

2009-10

Ben Seers
Topic: Designing and improving patient flow through a busy 24 hour accident & medical/urgent after-hours general practice.
Supervisors: Paul Abernethy, Les Toop, Simon Brokenshire
Sponsor: Partnership Health Canterbury

2008-09

Monica Johnson
Topic: Patient expectations for accessing after-hours health care in rural areas.
Awarded Best Speaker in the "Community" Category
Supervisors: Les Toop & Kelly Maw
Sponsor: Partnership Health Canterbury/Pegasus Health

2007-08

Dulia Halliday
Topic: General Practice Team Development Study
Supervisor: Les Toop, Co-Supervisors: Kelly Maw and Shelley Frost [Pegasus Health]
Sponsor: Partnership Health

2006-07

Anne-Marie Cumins
Topic: General Practice diabetes case detection audit.
Supervisors: Les Toop, Graham McGeoch and Maggie Wilson [Dept Public Health & General Practice and Pegasus Health]
Sponsor: Pegasus Health

^ Top of page

Publications

Malihi, Z., Lawes, C. M. M., Wu, Z., Huang, Y., Waayer, D., Toop, L., … Scragg, R. (2019). Monthly high-dose vitamin D supplementation does not increase kidney stone risk or serum calcium: Results from a randomized controlled trial. American Journal of Clinical Nutrition. Advance online publication. doi: 10.1093/ajcn/nqy378

Townsend, P., Toop, L., Aish, H., Jordan, L., & Cullen, F. (2019). Response to 'Elephants in the room" editorial, 1 February 2019. New Zealand Medical Journal, 132(1495), 86-87. Retrieved from http://www.nzma.org.nz/journal

Malihi, Z., Lawes, C. M. M., Wu, Z., Huang, Y., Waayer, D., Toop, L., … Scragg, R. (2018). Monthly high-dose vitamin D3 supplementation and self-reported adverse events in a 4-year randomized controlled trial. Clinical Nutrition. Advance online publication. doi: 10.1016/j.clnu.2018.07.034

Scragg, R., Khaw, K.-T., Toop, L., Sluyter, J., Lawes, C. M. M., Waayer, D., … Camargo, Jr, C. A. (2018). Monthly high-dose vitamin D supplementation and cancer risk: A post hoc analysis of the Vitamin D Assessment Randomized Clinical Trial. JAMA Oncology. Advance online publication. doi: 10.1001/jamaoncol.2018.2178

Win, S. S., Camargo, Jr, C. A., Khaw, K.-T., Lawes, C. M. M., Sluyter, J., Waayer, D., Toop, L., & Scragg, R. (2018). Cross-sectional associations of vitamin D status with asthma prevalence, exacerbations, and control in New Zealand adults. Journal of Steroid Biochemistry & Molecular Biology. Advance online publication. doi: 10.1016/j.jsbmb.2018.11.016

Chapter in Book - Research

Mintzes, B., Toop, L., & Mangin, D. (2009). Promotion to consumers: Responding to patient requests for advertised medicines. In B. Mintzes, D. Mangin & L. Hayes (Eds.), Understanding and responding to pharmaceutical promotion: A practical guide [Working draft for pilot field testing]. (pp. 81-104). World Health Organization & Health Action International. Retrieved from http://www.haiweb.org/11062009/drug-promotion-manual-CAP-3-090610.pdf

Toop, L. J. (1998). Patient Centred Primary Care. In Core Values in Primary Care. London: BMJ Books.

^ Top of page

Chapter in Book - Other

Toop, L. (2013). Public Health and General Practice. In P. Joyce, G. Nicholls, K. Thomas & T. Wilkinson (Eds.), The Christchurch experience: 40 years of research and teaching. (pp. 53-55). Christchurch, New Zealand: University of Otago.

Toop, L., & Mangin, D. (2013). Marketing of pharmaceuticals. In P. Joyce, G. Nicholls, K. Thomas & T. Wilkinson (Eds.), The Christchurch experience: 40 years of research and teaching. (pp. 177-182). Christchurch, New Zealand: University of Otago.

Toop, L. (2004). Principles of drug prescribing. In Volume 1: Principles and concepts: Oxford textbook of primary medical care. (pp. 242-245). Oxford University Press.

^ Top of page

Journal - Research Article

Malihi, Z., Lawes, C. M. M., Wu, Z., Huang, Y., Waayer, D., Toop, L., … Scragg, R. (2019). Monthly high-dose vitamin D supplementation does not increase kidney stone risk or serum calcium: Results from a randomized controlled trial. American Journal of Clinical Nutrition. Advance online publication. doi: 10.1093/ajcn/nqy378

Malihi, Z., Lawes, C. M. M., Wu, Z., Huang, Y., Waayer, D., Toop, L., … Scragg, R. (2018). Monthly high-dose vitamin D3 supplementation and self-reported adverse events in a 4-year randomized controlled trial. Clinical Nutrition. Advance online publication. doi: 10.1016/j.clnu.2018.07.034

Win, S. S., Camargo, Jr, C. A., Khaw, K.-T., Lawes, C. M. M., Sluyter, J., Waayer, D., Toop, L., & Scragg, R. (2018). Cross-sectional associations of vitamin D status with asthma prevalence, exacerbations, and control in New Zealand adults. Journal of Steroid Biochemistry & Molecular Biology. Advance online publication. doi: 10.1016/j.jsbmb.2018.11.016

Scragg, R., Khaw, K.-T., Toop, L., Sluyter, J., Lawes, C. M. M., Waayer, D., … Camargo, Jr, C. A. (2018). Monthly high-dose vitamin D supplementation and cancer risk: A post hoc analysis of the Vitamin D Assessment Randomized Clinical Trial. JAMA Oncology. Advance online publication. doi: 10.1001/jamaoncol.2018.2178

Wu, Z., Camargo, Jr, C. A., Khaw, K.-T., Waayer, D., Lawes, C. M. M., Toop, L., & Scragg, R. (2018). Effects of vitamin D supplementation on adherence and persistence with long-term statin therapy: Secondary analysis from the randomized, double-blind, placebo-controlled ViDA study. Atherosclerosis. Advance online publication. doi: 10.1016/j.atherosclerosis.2018.04.009

Wu, Z., Camargo, Jr, C. A., Sluyter, J. D., Khaw, K.-T., Malihi, Z., Waayer, D., Toop, L., … Scragg, R. (2018). Association between serum 25-hydroxyvitamin D levels and self-reported chronic pain in older adults: A cross-sectional analysis from the ViDA study. Journal of Steroid Biochemistry & Molecular Biology. Advance online publication. doi: 10.1016/j.jsbmb.2018.11.018

Wu, Z., Camargo, Jr, C. A., Malihi, Z., Bartley, J., Waayer, D., Lawes, C. M. M., Toop, L., … Scragg, R. (2018). Monthly vitamin D supplementation, pain, and pattern of analgesic prescription: Secondary analysis from the randomized, double-blind, placebo-controlled Vitamin D Assessment study. Pain, 159(6), 1074-1082. doi: 10.1097/j.pain.0000000000001189

Sluyter, J. D., Camargo, Jr, C. A., Waayer, D., Lawes, C. M. M., Toop, L., Khaw, K. T., & Scragg, R. (2017). Effect of monthly, high-dose, long-term vitamin D on lung function: A randomized controlled trial. Nutrients, 9(12), 1353. doi: 10.3390/nu9121353

Khaw, K.-T., Stewart, A. W., Waayer, D., Lawes, C. M. M., Toop, L., Camargo, Jr, C. A., & Scragg, R. (2017). Effect of monthly high-dose vitamin D supplementation on falls and non-vertebral fractures: Secondary and post-hoc outcomes from the randomised, double-blind, placebo-controlled ViDA trial. Lancet Diabetes & Endocrinology, 5(6), 438-447. doi: 10.1016/S2213-8587(17)30103-1

Scragg, R., Stewart, A. W., Waayer, D., Lawes, C. M. M., Toop, L., Sluyter, J., … Camargo, Jr, C. A. (2017). Effect of monthly high-dose vitamin D supplementation on cardiovascular disease in the Vitamin D Assessment Study: A randomized clinical trial. JAMA Cardiology, 2(6), 608-616. doi: 10.1001/jamacardio.2017.0175

Bagshaw, P., Bagshaw, S., Frampton, C., Gauld, R., Green, T., Harris, C., Hornblow, A., Hudson, B., … Toop, L. (2017). Pilot study of methods for assessing unmet secondary health care need in New Zealand. New Zealand Medical Journal, 130(1452), 23-38. Retrieved from https://www.nzma.org.nz/journal

Sluyter, J. D., Camargo, Jr, C. A., Stewart, A. W., Waayer, D., Lawes, C. M. M., Toop, L., … Scragg, R. (2017). Effect of monthly, high-dose, long-term vitamin D supplementation on central blood pressure parameters: A randomised controlled trial substudy. Journal of the American Heart Association, 6, e006802. doi: 10.1161/JAHA.117.006802

Scragg, R., Waayer, D., Stewart, A. W., Lawes, C. M. M., Toop, L., Murphy, J., … Camargo, Jr, C. A. (2015). The Vitamin D Assessment (ViDA) Study: Design of a randomized controlled trial of vitamin D supplementation for the prevention of cardiovascular disease, acute respiratory infection, falls and non-vertebral fractures. Journal of Steroid Biochemistry & Molecular Biology, 164, 318-325. doi: 10.1016/j.jsbmb.2015.09.010

Hudson, B., Toop, L., Mangin, D., Brunton, C., Jennings, L., & Fletcher, L. (2013). Pandemic influenza A(H1N1)pdm09: Risk of infection in primary healthcare workers. British Journal of General Practice, 63(611), e416-e422. doi: 10.3399/bjgp13X668212

Mangin, D., Murdoch, D., Wells, J. E., Coughlan, E., Bagshaw, S., Corwin, P., Chambers, S., & Toop, L. (2012). Chlamydia trachomatis testing sensitivity in midstream compared with first-void urine specimens. Annals of Family Medicine, 10(1), 50-53. doi: 10.1370/afm.1323

Toop, L. (2011). 1998 vision for year 2003 for members of Pegasus Medical Group. Journal of Primary Health Care, 3(1), 79-81.

Hudson, B., Toop, L., Mangin, D., & Pearson, J. (2011). Risk communication methods in hip fracture prevention: A randomised trial in primary care. British Journal of General Practice, 61(589), e469-e476. doi: 10.3399/bjgp11X588439

Vitry, A., Lexchin, J., Sasich, L., Dupin-Spriet, T., Reed, T., Bertele, V., … Toop, L., & Hurley, E. (2008). Provision of information on regulatory authorities' websites. Internal Medicine Journal, 38(7), 559-567.

Corwin, P., Toop, L., McGeoch, G., Than, M., Wynn-Thomas, S., Wells, J. E., Dawson, R., … Pithie, A., Chambers, S., Fletcher, L., & Richards, D. (2005). Randomised controlled trial of intravenous antibiotic treatment for cellulitis at home compared with hospital. British Medical Journal, 330(7483). Retrieved from http://www.bmj.com/cgi/reprint/330/7483/129

Richards, D. A., Toop, L. J., Epton, M. J., McGeoch, G. R. B., Town, G. I., Wynn-Thomas, S. M. H., Dawson, R. D., Hlavac, M. C., Werno, A. M., & Abernethy, P. D. (2005). Home management of mild to moderately severe community-acquired pneumonia: A randomised controlled trial. Medical Journal of Australia, 183(5), 235-238.

Richards, D., Toop, L., Chambers, S., & Fletcher, L. (2005). Response to antibiotics of women with symptoms of urinary tract infection but negative dipstick urine test results: Double blind randomised controlled trial. British Medical Journal, 331(7509). Retrieved from http://bmj.bmjjournals.com/cgi/content/abstract/331/7509/143

Mangin, D., Toop, L., Chambers, S., Ikram, R., & Harris, B. (2005). Increased rates of trimethoprim resistance in uncomplicated urinary tract infection: Cause for concern? New Zealand Medical Journal, 118(1225). Retrieved from http://journal.nzma.org.nz/journal/118-1225/1726/content.pdf

Richards, D. A., Toop, L. J., & Graham, P. J. (2003). Do clinical practice education groups result in sustained change in GP prescribing? Family Practice, 20(2), 199-206.

Botting, C., Sutherland, M., Wells, E., Town, I., Sainsbury, R., & Toop, L. (2003). The use of inhaled and related respiratory medications in Christchurch rest homes. New Zealand Medical Journal, 116(1187). Retrieved from http://journal.nzma.org.nz/journal/116-1187/709/content.pdf

Richards, D., Toop, L., Brockway, K., Graham, S., McSweeney, B., MacLean, D., … Parsons, A. (2003). Improving the effectiveness of smoking cessation in primary care: Lessons learned. New Zealand Medical Journal, 116(1173). Retrieved from http://journal.nzma.org.nz/journal/116-1173/417/content.pdf

McGeoch, G. R. B., Lainchbury, J. G., Town, G. I., Toop, L. J., Espiner, E. A., & Richards, A. M. (2002). Plasma brain natriuretic peptide after long-term treatment for heart failure in general practice. European Journal of Heart Failure, 4(4), 479-483.

Richards, D. A., Toop, L. J., Chambers, S., Sutherland, M. G., Harris, B., Ikram, R., … Peddie, B. A. (2002). Antibiotic resistance in uncomplicated urinary tract infection: Problems with interpreting cumulative resistance rates from local community laboratories. New Zealand Medical Journal, 115(1146), 12-14.

Richardson, A. K., Sutherland, M. G., Wells, J. E., Toop, L. J., & Plumridge, E. W. (2002). Factors affecting general practitioner involvement in a randomised controlled trial in primary care. New Zealand Medical Journal, 115, 153-155.

Williams, D., Barnett, P. S., & Toop, L. J. (1999). Preventive care in Canterbury general practice. New Zealand Medical Journal, 112(1088), 183-186.

Toop, L. J. (1998). Patient centred primary care. British Medical Journal, 316, 1882-1883.

Toop, L. J. (1998). Making practice nurse collaboration a reality. New Zealand Family Physician, 25(2), 35-36.

Watson, P. B., Town, G. I., Holbrook, N., Dwan, C., Toop, L. J., & Drennan, C. J. (1997). Evaluation of a self-management plan for chronic obstructive pulmonary disease. European Respiratory Journal, 10(6), 1267-1271.

Harre, E., Price, P. D., Ayrey, R. B., Toop, L. J., Martin, I. R., & Town, G. I. (1997). Respiratory effects of air pollution in chronic obstructive pulmonary disease: a three month prospective study. Thorax, 52(12), 1040-1044.

Toop, L. J., & Hodges, I. D. (1996). Primary care teamwork in the Christchurch area: Part 1: Health professionals actual and preferred levels of interdisciplinary contact and collaboration. New Zealand Family Physician, 23(6), 42-49.

Toop, L. J. (1996). Whose responsibility is it to manage pharmaceuticals? New Zealand Family Physician, 23, 17-19.

Toop, L. J., Nuthall, J. J., & Hodges, I. D. (1996). Primary care teamwork in the Christchurch area: Part 2: Barriers to greater collaboration. New Zealand Family Physician, 23(6), 51-59.

Gillies, J. D., Barry, D. M. J., Crane, J., Jones, D. T., MacLennan, L., Reid, J. J., Toop, L. J., & Pearce, N. E. M. (1996). A community trial of a written self management plan for children with asthma. New Zealand Medical Journal, 109, 30-33.

Town, G. I., Hodges, I. D., Wilkie, A. T., Toop, L. J., Graham, P. J. M., & Drennan, D. J. (1995). A community promotion of asthma self management in New Zealand. Patient Education & Counseling, 26, 219-224.

^ Top of page

Journal - Research Other

Townsend, P., Toop, L., Aish, H., Jordan, L., & Cullen, F. (2019). Response to 'Elephants in the room" editorial, 1 February 2019. New Zealand Medical Journal, 132(1495), 86-87. Retrieved from http://www.nzma.org.nz/journal

Toop, L. (2017). Steps towards more integrated care in New Zealand: A general practice perspective. BJGP Open, 1(1), 0845. doi: 10.3399/bjgpopen17X100845

Swinburn, B., Vandevijvere, S., on behalf of submitting health professors, including Hornblow, A., Taylor, B., Drummond, B., Murdoch, D., Mangin, D., Sarfati, D., Sellman, D., Sopoaga, F., Thomson, G., Abel, G., Hoek, J., Connor, J., Krebs, J., Mann, J., McCall, J., Broughton, J., Toop, L., Signal, L., Beckert, L., Farella, M., Baker, M., Keall, M., Skeaff, M., Thomson, M., Wilson, N., Chandler, N., Priest, P., Brunton, P., Crampton, P., Gendall, P., Howden-Chapman, P., Taylor, R., Edwards, R., Gauld, R., McGee, R., Mulder, R., Derrett, S., Hales, S., Pullon, S., & Blakely, T. (2017). Proposed new industry code on unhealthy food marketing to children and young people: Will it make a difference? New Zealand Medical Journal, 130(1450), 94-101. Retrieved from http://www.nzma.org.nz/journal

Mulder, R., Rucklidge, J. J., & Toop, L. (2016). Restoring Study 329: Paroxetine neither effective nor safe for adolescents. Australian & New Zealand Journal of Psychiatry, 50(9), 922-923. doi: 10.1177/0004867416657412

Toop, L., & Mangin, D. (2015). The art and science of marketing medications. New Zealand Medical Journal, 128(1421). Retrieved from https://www.nzma.org.nz/journal

Hudson, B., Williman, J. A., Stamp, L. K., Alchin, J. S., Hooper, G. J., Mangin, D., Thompson, B. F., & Toop, L. (2015). Nortriptyline in knee osteoarthritis (NortIKA Study): Study protocol for a randomised controlled trial. Trials, 16, 448. doi: 10.1186/s13063-015-0961-1

Toop, L., & Jackson, C. (2015). Patient co-payment for general practice services: Slippery slope or a survival imperative for the NHS? British Journal of General Practice, 65(635), 276-277. doi: 10.3399/bjgp15X685105

More publications...