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Director, General Practice Research Group Dee Mangin

MB ChB DPH(Otago)
Director, McMaster University Sentinel and Information Collaboration (M.U.S.I.C.)

Email dee.mangin@otago.ac.nz

Research Interests

Dee Mangin is a New Zealand family physician who is currently Professor and Director of the Primary Care Research Group at the University of Otago, Christchurch. She is also the David Braley Nancy Gordon Chair in Family Medicine at McMaster University, Canada.

Her interests are rational prescribing, and the influences of science, policy and commerce on the nature of care.

Expertise spans generation of clinical evidence using randomised controlled trials, the effects of pharmaceutical company promotion to consumers and physicians, effective medicine use in older age, innovative models of general practice care and effective incorporation of evidence into patient-centered practice.

She has been a member of the Pharmaceutical and Therapeutic Products Advisory Committee.

Student Supervision

Nagham Ailabouni
Degree: PhD
Topic: De-prescribing discontinuation of unnecessary medicines in frail older people in New Zealand.
Supervisors: Dr June Tordoff, Professor Dee Mangin and Dr Prasad Nishtala

2014-15

Abigail Boyer
Topic: Evaluation of Pegasus Health's "Stop Smoking Support Options" Programme
Supervisors: Dr Lynley Cook and Associate Professor Dee Mangin
Sponsor: Pegasus Health (Charitable) Ltd

2012-13

Matthew Chamberlain
Topic: Psychological impact of September 2010 and subsequent earthquakes on Christchurch general practice patients.
Supervisors: Dee Mangin, Cerina Altenburg
Sponsor: The Royal New Zealand College of General Practitioners

Georgie Malcolm 
Topic: Developing an evidence based pathway for UTI management in the primary/urgent care setting.
Supervisor: Dee Mangin
Co-supervisor: Louisa Sullivan
Sponsor: Pegasus Health 

2010-11

Jasmine Gooda
Topic: Low dose antipsychotic use and metabolic side effects.
Supervisor: Dee Mangin
Sponsor: Pegasus Health

2009-10

Monica Johnson
Topic: Polypharmacy in the elderly – evaluating the Pill Pruner project.
Supervisors: Dee Mangin, Andrea Copeland, Nikki Ford
Sponsor: Pegasus Health

2008-09

Lauren Cumberpatch
Topic: The views of older adults on medicine use in treatment and prevention.
Supervisors: Dee Mangin & Kim Burgess
Sponsor: The Canterbury Health Care of the Elderly Education Trust

2007-08

Meagan McLeod ()
Topic: Comparison of the effectiveness of General Practice cervical screening systems.
Supervisor: Dee Mangin
Co-Supervisor Vivian Daley [Pegasus Health]
Sponsor: Pegasus Health IPA

2005-06

Charlotte Duncan
Topic: What are the drivers of PSA testing in Pegasus GPs?
Supervisors: Paul Corwin, Dee Mangin
Sponsor: Otago Theme Bursary, University of Otago

2004-05

Kris Wilson
Topic: A comparison of parental attitudes towards complementary and alternative medicines in children.
Supervisors: Dee Richards and Claire Dowson

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Publications

Turk, A., Wong, G., Mahtani, K. R., Madden, M., Hill, R., Ranson, E., … Mangin, D., … Reeve, J. (2022). Optimising a person-centered approach to stopping medicines in older people with multimorbidity and polypharmacy using the DExTruS framework: A realist review. BMC Medicine, 20, 297. doi: 10.1186/s12916-022-02475-1

Reeve, J., Maden, M., Hill, R., Turk, A., Mahtani, K., Wong, G., … Mangin, D., … Radson, E. (2022). Deprescribing medicines in older people living with multimorbidity and polypharmacy: The TAILOR evidence synthesis. Health Technology Assessment, 26(32). doi: 10.3310/AAFO2475

Clarke, C. S., Duffy, L., Lewis, G., Freemantle, N., Gilbody, S., Kendrick, T., … Mangin, D., … Hunter, R. M. (2022). Cost-utility analysis of discontinuing antidepressants in England primary care patients compared with long-term maintenance: The ANTLER study. Applied Health Economics & Health Policy, 20, 269-282. doi: 10.1007/s40258-021-00693-x

Lamarche, L., Clark, R. E., Parascandalo, F., & Mangin, D. (2022). The implementation and validation of the NoMAD during a complex primary care intervention. BMC Medical Research Methodology, 22, 175. doi: 10.1186/s12874-022-01655-0

Clarke, C. S., Duffy, L., Lewis, G., Freemantle, N., Gilbody, S., Kendrick, T., … Mangin, D., … Hunter, R. M. (2022). Impact of depression relapse on participant quality of life and costs to the English NHS: Secondary analysis from the ANTLER study on antidepressant discontinuation in well patients in primary care. Value in Health, 25(7, Suppl.), (pp. S375). doi: 10.1016/j.jval.2022.04.463

Ingham, T., Jones, B., on behalf of the Pharmacovigilance Ethics Advisory Group, including Smith, B., Mangin, D., & Moore, A. (Eds.). (2012). Medicine safety for New Zealanders: Ethical issue regarding the use of routinely collected data from general practice for pharmacovigilance (Draft ed.). Wellington, New Zealand: University Of Otago, 46p.

Edited Book - Research

Mintzes, B., Mangin, D., & Hayes, L. (Eds.). (2009). Understanding and responding to pharmaceutical promotion: A practical guide [Working draft for pilot field testing]. World Health Organization & Health Action International. Retrieved from http://www.haiweb.org/11062009/drug-promotion-manual-CAP-3-090610.pdf

Edited Book - Research

Healy, D., & Mangin, D. (2016). Does my bias look big in this? In F. Baylis & A. Ballantyne (Eds.), Clinical research involving pregnant women. (pp. 197-208). Springer. doi: 10.1007/978-3-319-26512-4_11

Chapter in Book - Research

Mangin, D. (2016). The contribution of primary care research to improving health services. In F. Goodyear-Smith & B. Mash (Eds.), International perspectives on primary care research. (pp. 67-72). Boca Raton, FL: CRC Press.

Chapter in Book - Research

Mangin, D. (2015). A primary care perspective on prescribing for women. In M. Harrison-Woolrych (Ed.), Medicines for women. (pp. 403-432). Springer.

Chapter in Book - Research

Mangin, D., & Heath, I. (2012). Polifarmácia [Polypharmacy]. In G. Gusso & J. M. C. Lopes (Eds.), Tratado de medicina de família e comunidadae [Textbook of family and community medicine]. (pp. 198-204). artmed.

Chapter in Book - Research

Starfield, B., & Mangin, D. (2011). An international perspective on the basis of pay-for-performance. In S. Gillam & A. N. Siriwardena (Eds.), The quality and outcomes framework (QOF): Transforming general practice. (pp. 147-155). Abingdon, UK: Radcliffe.

Chapter in Book - Research

Mangin, D. (2009). Promotion, professional practice and patient trust. In B. Mintzes, D. Mangin & L. Hayes (Eds.), Understanding and responding to pharmaceutical promotion: A practical guide [Working draft for pilot field testing]. (pp. 163-173). World Health Organization & Health Action International. Retrieved from http://www.haiweb.org/11062009/drug-promotion-manual-CAP-3-090610.pdf

Chapter in Book - Research

Mintzes, B., Toop, L., & Mangin, D. (2009). Promotion to consumers: Responding to patient requests for advertised medicines. In B. Mintzes, D. Mangin & L. Hayes (Eds.), Understanding and responding to pharmaceutical promotion: A practical guide [Working draft for pilot field testing]. (pp. 81-104). World Health Organization & Health Action International. Retrieved from http://www.haiweb.org/11062009/drug-promotion-manual-CAP-3-090610.pdf

Chapter in Book - Research

Toop, L., & Mangin, D. (2013). Marketing of pharmaceuticals. In P. Joyce, G. Nicholls, K. Thomas & T. Wilkinson (Eds.), The Christchurch experience: 40 years of research and teaching. (pp. 177-182). Christchurch, New Zealand: University of Otago.

Chapter in Book - Other

Bayliss, E. A., Albers, K., Gleason, K., Pieper, L. E., Boyd, C. M., Campbell, N. L., … Mangin, D., … Dublin, S. (2022). Recommendations for outcome measurement for deprescribing intervention studies. Journal of the American Geriatrics Society. Advance online publication. doi: 10.1111/jgs.17894

Journal - Research Article

Clarke, C. S., Duffy, L., Lewis, G., Freemantle, N., Gilbody, S., Kendrick, T., … Mangin, D., … Hunter, R. M. (2022). Cost-utility analysis of discontinuing antidepressants in England primary care patients compared with long-term maintenance: The ANTLER study. Applied Health Economics & Health Policy, 20, 269-282. doi: 10.1007/s40258-021-00693-x

Journal - Research Article

Di Pelino, S., Lamarche, L., Carr, T., Datta, J., Gaber, J., Oliver, D., … Mangin, D. (2022). Lessons learned through two phases of developing and implementing a technology supporting integrated care: Case study. JMIR Formative Research, 6(4), e34899. doi: 10.2196/34899

Journal - Research Article

Gaber, J., Clark, R. E., Lamarche, L., Datta, J., Talat, S., Bomze, S., … Mangin, D. (2022). Understanding volunteer retention in a complex, community-centred intervention: A mixed methods study in Ontario, Canada. Health & Social Care in the Community. Advance online publication. doi: 10.1111/hsc.13775

Journal - Research Article

Gaber, J., Datta, J., Clark, R., Lamarche, L., Parascandalo, F., Di Pelino, S., … Mangin, D., & Price, D. (2022). Understanding how context and culture in six communities can shape implementation of a complex intervention: A comparative case study. BMC Health Services Research, 22, 221. doi: 10.1186/s12913-022-07615-0

Journal - Research Article

Gaber, J., Di Pelino, S., Datta, J., Talat, S., Browne, T., Marentette-Brown, S., … Mangin, D. (2022). Community volunteers and primary care providers supporting older adults in system navigation: A mixed methods study. International Journal of Integrated Care, 22(1), 18. doi: 10.5334/ijic.5978

Journal - Research Article

Healy, D., Bahrick, A., Bak, M., Barbato, A., Calabrò, R. S., Chubak, B. M., … Mangin, D., … Waraich, A. (2022). Diagnostic criteria for enduring sexual dysfunction after treatment with antidepressants, finasteride and isotretinoin. International Journal of Risk & Safety in Medicine, 33, 65-76. doi: 10.3233/JRS-210023

Journal - Research Article

Healy, D., Mangin, D., & Lochhead, J. (2022). Development and persistence of patient-reported visual problems associated with serotonin reuptake inhibiting antidepressants. International Journal of Risk & Safety in Medicine, 33(1), 37-47. doi: 10.3233/JRS-210018

Journal - Research Article

Lamarche, L., Clark, R. E., Parascandalo, F., & Mangin, D. (2022). The implementation and validation of the NoMAD during a complex primary care intervention. BMC Medical Research Methodology, 22, 175. doi: 10.1186/s12874-022-01655-0

Journal - Research Article

Morrow, R. L., Mintzes, B., Souverein, P. C., De Bruin, M. L., Roughead, E. E., Lexchin, J., … Mangin, D., … Dormuth, C. R. (2022). Influence of drug safety advisories on drug utilization: An international interrupted time series and meta-analysis study. BMJ Quality & Safety, 31, 179-190. doi: 10.1136/bmjqs-2021-013910

Journal - Research Article

Morrow, R. L., Mintzes, B., Souverein, P. C., Hallgreen, C. E., Ahmed, B., Roughead, E. E., … Mangin, D., … Dormuth, C. R. (2022). Hydroxyzine initiation following drug safety advisories on cardiac arrhythmias in the UK and Canada: A longitudinal cohort study. Drug Safety, 45, 623-638. doi: 10.1007/s40264-022-01175-2

Journal - Research Article

Reeve, J., Maden, M., Hill, R., Turk, A., Mahtani, K., Wong, G., … Mangin, D., … Radson, E. (2022). Deprescribing medicines in older people living with multimorbidity and polypharmacy: The TAILOR evidence synthesis. Health Technology Assessment, 26(32). doi: 10.3310/AAFO2475

Journal - Research Article

Turk, A., Wong, G., Mahtani, K. R., Madden, M., Hill, R., Ranson, E., … Mangin, D., … Reeve, J. (2022). Optimising a person-centered approach to stopping medicines in older people with multimorbidity and polypharmacy using the DExTruS framework: A realist review. BMC Medicine, 20, 297. doi: 10.1186/s12916-022-02475-1

Journal - Research Article

Aponte-Hao, S., Wong, S. T., Thandi, M., Ronksley, P., McBrien, K., Lee, J., … Mangin, D., … Williamson, T. (2021). Machine learning for identification of frailty in Canadian primary care practices. International Journal of Population Data Science, 6(1), 11. doi: 10.23889/ijpds.v6i1.1650

Journal - Research Article

Duffy, L., Clarke, C. S., Lewis, G., Marston, L., Freemantle, N., Gilbody, S., … Mangin, D., … Lewis, G. (2021). Antidepressant medication to prevent depression relapse in primary care: The ANTLER RCT. Health Technology Assessment, 25(69), 1-62. doi: 10.3310/hta25690

Journal - Research Article

Hudson, B., Williman, J. A., Stamp, L. K., Alchin, J. S., Hooper, G. J., Mangin, D., Lennox Thompson, B. F., & Toop, L. (2021). Nortriptyline for pain in knee osteoarthritis in general practice: A double blind randomised controlled trial. British Journal of General Practice, 71(708), e538-e546. doi: 10.3399/bjgp.2020.0797

Journal - Research Article

Lewis, G., Marston, L., Duffy, L., Freemantle, N., Gilbody, S., Hunter, R., … Mangin, D., … Lewis, G. (2021). Maintenance or discontinuation of antidepressants in primary care. New England Journal of Medicine, 385, 1257-1267. doi: 10.1056/NEJMoa2106356

Journal - Research Article

Mangin, D., & Siu, H. Y.-H. (2021). Deprescribing antidepressants in older people: Breaking up can be hard to do. Senior Care Pharmacist, 36(5), 228-237. doi: 10.4140/TCP.n.2021.228

Journal - Research Article

Thandi, M., Wong, S. T., Aponte-Hao, S., Grandy, M., Mangin, D., Singer, A., & Williamson, T. (2021). Strategies for working across Canadian practice-based research and learning networks (PBRLNs) in primary care: Focus on frailty. BMC Family Practice, 22, 220. doi: 10.1186/s12875-021-01573-y

Journal - Research Article

Dolovich, L., Gaber, J., Valaitis, R., Ploeg, J., Oliver, D., Richardson, J., Mangin, D., … Agarwal, G. (2020). Exploration of volunteers as health connectors within a multicomponent primary care-based program supporting self-management of diabetes and hypertension. Health & Social Care in the Community, 28(3), 734-746. doi: 10.1111/hsc.12904

Journal - Research Article

Mangin, D., Lawson, J., Adamczyk, K., & Guenter, D. (2020). Embedding "smart" disease coding within routine electronic medical record workflow: Prospective single-arm trial. JMIR Medical Informatics, 8(7), e16764. doi: 10.2196/16764

Journal - Research Article

Santaguida, P. L., Oliver, D., Gilsing, A., Lamarche, L., Griffith, L. E., Mangin, D., … Dolovich, L. (2020). Delphi consensus on core criteria set selecting among health-related outcome measures (HROM) in primary health care. Journal of Clinical Epidemiology, 127, 105-116. doi: 10.1016/j.jclinepi.2020.04.028

Journal - Research Article

Agarwal, G., Gaber, J., Richardson, J., Mangin, D., Ploeg, J., Valaitis, R., … Dolovich, L. (2019). Pilot randomized controlled trial of a complex intervention for diabetes self-management supported by volunteers, technology, and interprofessional primary health care teams. Pilot & Feasibility Studies, 5, 118. doi: 10.1186/s40814-019-0504-8

Journal - Research Article

Ailabouni, N., Mangin, D., & Nishtala, P. S. (2019). DEFEAT-polypharmacy: Deprescribing anticholinergic and sedative medicines feasibility trial in residential aged care facilities. International Journal of Clinical Pharmacy, 41, 167-178. doi: 10.1007/s11096-019-00784-9

Journal - Research Article

Bello, A. K., Ronksley, P. E., Tangri, N., Kurzawa, J., Osman, M. A., Singer, A., … Mangin, D., & Drummond, N. (2019). Prevalence and demographics of CKD in Canadian primary care practices: A cross-sectional study. Kidney International Reports, 4(4), 561-570. doi: 10.1016/j.ekir.2019.01.005

Journal - Research Article

Bello, A. K., Ronksley, P. E., Tangri, N., Kurzawa, J., Osman, M. A., Singer, A., … Mangin, D., & Drummond, N. (2019). Quality of chronic kidney disease management in Canadian primary care. JAMA Network Open, 2(9), e1910704. doi: 10.1001/jamanetworkopen.2019.10704

Journal - Research Article

Currie, O., Williman, J., Mangin, D., McKinnon-Gee, B., & Bridgford, P. (2019). Comparative risk of new-onset diabetes following commencement of antipsychotics in New Zealand: A population-based clustered multiple baseline time series design. BMJ Open, 9(2), e022984. doi: 10.1136/bmjopen-2018-022984

Journal - Research Article

Dolovich, L., Oliver, D., Lamarche, L., Thabane, L., Valaitis, R., Agarwal, G., … Mangin, D., … Price, D. (2019). Combining volunteers and primary care teamwork to support health goals and needs of older adults: A pragmatic randomized controlled trial. CMAJ, 191, E491-E500. doi: 10.1503/cmaj.181173

Journal - Research Article

Griffith, L. E., Gilsing, A., Mangin, D., Patterson, C., van den Heuvel, E., Sohel, N., … Raina, P. (2019). Multimorbidity frameworks impact prevalence and relationships with patient-important outcomes. Journal of the American Geriatrics Society, 67(8), 1632-1640. doi: 10.1111/jgs.15921

Journal - Research Article

Healy, D., Le Noury, J., & Mangin, D. (2019). Post-SSRI sexual dysfunction: Patient experiences of engagement with healthcare professionals. International Journal of Risk & Safety in Medicine, 30, 167-178. doi: 10.3233/JRS-191005

Journal - Research Article

Mangin, D., Parascandalo, J., Khudoyarova, O., Agarwal, G., Bismah, V., & Orr, S. (2019). Multimorbidity, eHealth and implications for equity: A cross-sectional survey of patient perspectives on eHealth. BMJ Open, 9, e023731. doi: 10.1136/bmjopen-2018-023731

Journal - Research Article

Mangin, D., Risdon, C., Lamarche, L., Langevin, J., Ali, A., Parascandalo, J., … Trimble, J. (2019). 'I think this medicine actually killed my wife': Patient and family perspectives on shared-decision-making to optimize medications and safety. Therapeutic Advances in Drug Safety, 10. doi: 10.1177/2042098619838796

Journal - Research Article

Millar, E., Gurney, J., Stanley, J., Stairmand, J., Davies, C., Semper, K., Dowell, A., Lawrenson, R., Mangin, D., & Sarfati, D. (2019). Pill for this and a pill for that: A cross-sectional survey of use and understanding of medication among adults with multimorbidity. Australasian Journal on Ageing, 38(2), 91-97. doi: 10.1111/ajag.12606

Journal - Research Article

Ploeg, J., Valaitis, R. K., Cleghorn, L., Yous, M.-L., Gaber, J., Agarwal, G., … Mangin, D., … Dolovich, L. (2019). Perceptions of older adults in Ontario, Canada on the implementation and impact of a primary care programme, Health Teams Advancing Patient Experience: Strengthening Quality (Health TAPESTRY): A descriptive qualitative study. BMJ Open, 9, e026257. doi: 10.1136/bmjopen-2018-026257

Journal - Research Article

Siu, H. Y.-H., Delleman, B., Langevin, J., Mangin, D., Howard, M., Fang, Q., … Chan, D. (2019). Demonstrating a technology-mediated intervention to support medication adherence in community-dwelling older adults in primary care: A feasibility study. Gerontology & Geriatric Medicine, 5. doi: 10.1177/2333721419845179

Journal - Research Article

Javadi, D., Lamarche, L., Avilla, E., Siddiqui, R., Gaber, J., Bhamani, M., … Mangin, D., & Dolovich, L. (2018). Feasibility study of goal setting discussions between older adults and volunteers facilitated by an eHealth application: Development of the Health TAPESTRY approach. Pilot & Feasibility Studies, 4, 184. doi: 10.1186/s40814-018-0377-2

Journal - Research Article

Mangin, D., Lawson, J., Cuppage, J., Shaw, E., Ivanyi, K., Davis, A., & Risdon, C. (2018). Legacy drug-prescribing patterns in primary care. Annals of Family Medicine, 16(6), 515-520. doi: 10.1370/afm.2315

Journal - Research Article

Stairmand, J., Gurney, J., Stanley, J., Millar, E., Davies, C., Semper, K., Dowell, A., Mangin, D., Lawrenson, R., & Sarfati, D. (2018). The impact of multimorbidity on people's lives: A cross-sectional survey. New Zealand Medical Journal, 131(1477), 78-90. Retrieved from https://www.nzma.org.nz/journal

Journal - Research Article

Ailabouni, N., Mangin, D., & Nishtala, P. S. (2017). Can deprescribing give what polypharmacy has taken away? Feasibility trial in residential aged care. Innovation in Aging, 1(Suppl. 1), 588-589. doi: 10.1093/geroni/igx004.2065

Journal - Research Article

Ailabouni, N., Mangin, D., & Nishtala, P. S. (2017). Deprescribing anticholinergic and sedative medicines: Protocol for a feasibility trial (DEFEAT-polypharmacy) in residential aged care facilities. BMJ Open, 7(4), e013800. doi: 10.1136/bmjopen-2016-013800

Journal - Research Article

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