Director, General Practice Research Group
MB ChB DPH(Otago)
Director, McMaster University Sentinel and Information Collaboration (M.U.S.I.C.)
Email dee.mangin@otago.ac.nz
Research Interests
Dee Mangin is a New Zealand family physician who is currently Professor and Director of the Primary Care Research Group at the University of Otago, Christchurch. She is also the David Braley Nancy Gordon Chair in Family Medicine at McMaster University, Canada.
Her interests are rational prescribing, and the influences of science, policy and commerce on the nature of care.
Expertise spans generation of clinical evidence using randomised controlled trials, the effects of pharmaceutical company promotion to consumers and physicians, effective medicine use in older age, innovative models of general practice care and effective incorporation of evidence into patient-centered practice.
She has been a member of the Pharmaceutical and Therapeutic Products Advisory Committee.
Student Supervision
Nagham Ailabouni
Degree: PhD
Topic: De-prescribing discontinuation of unnecessary medicines in frail older people in New Zealand.
Supervisors: Dr June Tordoff, Professor Dee Mangin and Dr Prasad Nishtala
2014-15
Abigail Boyer
Topic: Evaluation of Pegasus Health's "Stop Smoking Support Options" Programme
Supervisors: Dr Lynley Cook and Associate Professor Dee Mangin
Sponsor: Pegasus Health (Charitable) Ltd
2012-13
Matthew Chamberlain
Topic: Psychological impact of September 2010 and subsequent earthquakes on Christchurch general practice patients.
Supervisors: Dee Mangin, Cerina Altenburg
Sponsor: The Royal New Zealand College of General Practitioners
Georgie Malcolm
Topic: Developing an evidence based pathway for UTI management in the primary/urgent care setting.
Supervisor: Dee Mangin
Co-supervisor: Louisa Sullivan
Sponsor: Pegasus Health
2010-11
Jasmine Gooda
Topic: Low dose antipsychotic use and metabolic side effects.
Supervisor: Dee Mangin
Sponsor: Pegasus Health
2009-10
Monica Johnson
Topic: Polypharmacy in the elderly – evaluating the Pill Pruner project.
Supervisors: Dee Mangin, Andrea Copeland, Nikki Ford
Sponsor: Pegasus Health
2008-09
Lauren Cumberpatch
Topic: The views of older adults on medicine use in treatment and prevention.
Supervisors: Dee Mangin & Kim Burgess
Sponsor: The Canterbury Health Care of the Elderly Education Trust
2007-08
Meagan McLeod ()
Topic: Comparison of the effectiveness of General Practice cervical screening systems.
Supervisor: Dee Mangin
Co-Supervisor Vivian Daley [Pegasus Health]
Sponsor: Pegasus Health IPA
2005-06
Charlotte Duncan
Topic: What are the drivers of PSA testing in Pegasus GPs?
Supervisors: Paul Corwin, Dee Mangin
Sponsor: Otago Theme Bursary, University of Otago
2004-05
Kris Wilson
Topic: A comparison of parental attitudes towards complementary and alternative medicines in children.
Supervisors: Dee Richards and Claire Dowson
Publications
Mangin, D., Lamarche, L., Agarwal, G., Ali, A., Cassels, A., Colwill, K., … Trimble, J. (2023). Team approach to polypharmacy evaluation and reduction: Feasibility randomized trial of a structured clinical pathway to reduce polypharmacy. Pilot & Feasibility Studies, 9, 84. doi: 10.1186/s40814-023-01315-0
Mangin, D., Lawson, J., Risdon, C., Siu, H. Y.-H., Packer, T., Wong, S. T., & Howard, M. (2023). Association between frailty, chronic conditions and socioeconomic status in community-dwelling older adults attending primary care: A cross-sectional study using practice-based research network data. BMJ Open, 13, e066269. doi: 10.1136/bmjopen-2022-066269
Mangin, D., Lamarche, L., Oliver, D., Blackhouse, G., Bomze, S., Borhan, S., … Price, D. (2023). Health TAPESTRY Ontario: A multi-site randomized controlled trial testing implementation and reproducibility. Annals of Family Medicine, 21(2), 132-142. doi: 10.1370/afm.2944
Farrell, B., Raman-Wilms, L., Sadowski, C. A., Mallery, L., Turner, J., Gagnon, C., … Mangin, D., … Upshur, R. (2023). A proposed curricular framework for an interprofessional approach to deprescribing. Medical Science Educator. Advance online publication. doi: 10.1007/s40670-022-01704-9
Jamieson, H., Nishtala, P. S., Bergler, H. U., Weaver, S. K., Pickering, J. W., Ailabouni, N. J., Abey-Nesbit, R., … Mangin, D. (2023). Deprescribing anticholinergic and sedative drugs to reduce polypharmacy in frail older adults living in the community: A randomized controlled trial. Journals of Gerontology Series A, glac249. Advance online publication. doi: 10.1093/gerona/glac249
Ingham, T., Jones, B., on behalf of the Pharmacovigilance Ethics Advisory Group, including Smith, B., Mangin, D., & Moore, A. (Eds.). (2012). Medicine safety for New Zealanders: Ethical issue regarding the use of routinely collected data from general practice for pharmacovigilance (Draft ed.). Wellington, New Zealand: University Of Otago, 46p.
Edited Book - Research
Mintzes, B., Mangin, D., & Hayes, L. (Eds.). (2009). Understanding and responding to pharmaceutical promotion: A practical guide [Working draft for pilot field testing]. World Health Organization & Health Action International. Retrieved from http://www.haiweb.org/11062009/drug-promotion-manual-CAP-3-090610.pdf
Edited Book - Research
Healy, D., & Mangin, D. (2016). Does my bias look big in this? In F. Baylis & A. Ballantyne (Eds.), Clinical research involving pregnant women. (pp. 197-208). Springer. doi: 10.1007/978-3-319-26512-4_11
Chapter in Book - Research
Mangin, D. (2016). The contribution of primary care research to improving health services. In F. Goodyear-Smith & B. Mash (Eds.), International perspectives on primary care research. (pp. 67-72). Boca Raton, FL: CRC Press.
Chapter in Book - Research
Mangin, D. (2015). A primary care perspective on prescribing for women. In M. Harrison-Woolrych (Ed.), Medicines for women. (pp. 403-432). Springer.
Chapter in Book - Research
Mangin, D., & Heath, I. (2012). Polifarmácia [Polypharmacy]. In G. Gusso & J. M. C. Lopes (Eds.), Tratado de medicina de família e comunidadae [Textbook of family and community medicine]. (pp. 198-204). artmed.
Chapter in Book - Research
Starfield, B., & Mangin, D. (2011). An international perspective on the basis of pay-for-performance. In S. Gillam & A. N. Siriwardena (Eds.), The quality and outcomes framework (QOF): Transforming general practice. (pp. 147-155). Abingdon, UK: Radcliffe.
Chapter in Book - Research
Mangin, D. (2009). Promotion, professional practice and patient trust. In B. Mintzes, D. Mangin & L. Hayes (Eds.), Understanding and responding to pharmaceutical promotion: A practical guide [Working draft for pilot field testing]. (pp. 163-173). World Health Organization & Health Action International. Retrieved from http://www.haiweb.org/11062009/drug-promotion-manual-CAP-3-090610.pdf
Chapter in Book - Research
Mintzes, B., Toop, L., & Mangin, D. (2009). Promotion to consumers: Responding to patient requests for advertised medicines. In B. Mintzes, D. Mangin & L. Hayes (Eds.), Understanding and responding to pharmaceutical promotion: A practical guide [Working draft for pilot field testing]. (pp. 81-104). World Health Organization & Health Action International. Retrieved from http://www.haiweb.org/11062009/drug-promotion-manual-CAP-3-090610.pdf
Chapter in Book - Research
Toop, L., & Mangin, D. (2013). Marketing of pharmaceuticals. In P. Joyce, G. Nicholls, K. Thomas & T. Wilkinson (Eds.), The Christchurch experience: 40 years of research and teaching. (pp. 177-182). Christchurch, New Zealand: University of Otago.
Chapter in Book - Other
Farrell, B., Raman-Wilms, L., Sadowski, C. A., Mallery, L., Turner, J., Gagnon, C., … Mangin, D., … Upshur, R. (2023). A proposed curricular framework for an interprofessional approach to deprescribing. Medical Science Educator. Advance online publication. doi: 10.1007/s40670-022-01704-9
Journal - Research Article
Jamieson, H., Nishtala, P. S., Bergler, H. U., Weaver, S. K., Pickering, J. W., Ailabouni, N. J., Abey-Nesbit, R., … Mangin, D. (2023). Deprescribing anticholinergic and sedative drugs to reduce polypharmacy in frail older adults living in the community: A randomized controlled trial. Journals of Gerontology Series A, glac249. Advance online publication. doi: 10.1093/gerona/glac249
Journal - Research Article
Mangin, D., Lamarche, L., Agarwal, G., Ali, A., Cassels, A., Colwill, K., … Trimble, J. (2023). Team approach to polypharmacy evaluation and reduction: Feasibility randomized trial of a structured clinical pathway to reduce polypharmacy. Pilot & Feasibility Studies, 9, 84. doi: 10.1186/s40814-023-01315-0
Journal - Research Article
Mangin, D., Lamarche, L., Oliver, D., Blackhouse, G., Bomze, S., Borhan, S., … Price, D. (2023). Health TAPESTRY Ontario: A multi-site randomized controlled trial testing implementation and reproducibility. Annals of Family Medicine, 21(2), 132-142. doi: 10.1370/afm.2944
Journal - Research Article
Mangin, D., Lawson, J., Risdon, C., Siu, H. Y.-H., Packer, T., Wong, S. T., & Howard, M. (2023). Association between frailty, chronic conditions and socioeconomic status in community-dwelling older adults attending primary care: A cross-sectional study using practice-based research network data. BMJ Open, 13, e066269. doi: 10.1136/bmjopen-2022-066269
Journal - Research Article
Page, A. T., Potter, K., Naganathan, V., Hilmer, S., McLachlan, A. J., Lindley, R. I., … Mangin, D., & Etherton-Beer, C. (2023). Polypharmacy and medicine regimens in older adults in residential aged care. Archives of Gerontology & Geriatrics, 105, 104849. doi: 10.1016/j.archger.2022.104849
Journal - Research Article
Quek, H. W., Etherton-Beer, C., Page, A., McLachlan, A. J., Lo, S. Y., Naganathan, V., … Mangin, D., … Potter, K. (2023). Deprescribing for older people living in residential aged care facilities: Pharmacist recommendations, doctor acceptance and implementation. Archives of Gerontology & Geriatrics, 107, 104910. doi: 10.1016/j.archger.2022.104910
Journal - Research Article
Bayliss, E. A., Albers, K., Gleason, K., Pieper, L. E., Boyd, C. M., Campbell, N. L., … Mangin, D., … Dublin, S. (2022). Recommendations for outcome measurement for deprescribing intervention studies. Journal of the American Geriatrics Society. Advance online publication. doi: 10.1111/jgs.17894
Journal - Research Article
Clarke, C. S., Duffy, L., Lewis, G., Freemantle, N., Gilbody, S., Kendrick, T., … Mangin, D., … Hunter, R. M. (2022). Cost-utility analysis of discontinuing antidepressants in England primary care patients compared with long-term maintenance: The ANTLER study. Applied Health Economics & Health Policy, 20, 269-282. doi: 10.1007/s40258-021-00693-x
Journal - Research Article
Di Pelino, S., Lamarche, L., Carr, T., Datta, J., Gaber, J., Oliver, D., … Mangin, D. (2022). Lessons learned through two phases of developing and implementing a technology supporting integrated care: Case study. JMIR Formative Research, 6(4), e34899. doi: 10.2196/34899
Journal - Research Article
Gaber, J., Clark, R. E., Lamarche, L., Datta, J., Talat, S., Bomze, S., … Mangin, D. (2022). Understanding volunteer retention in a complex, community-centred intervention: A mixed methods study in Ontario, Canada. Health & Social Care in the Community, 30(6), 2259-2269. doi: 10.1111/hsc.13775
Journal - Research Article
Gaber, J., Datta, J., Clark, R., Lamarche, L., Parascandalo, F., Di Pelino, S., … Mangin, D., & Price, D. (2022). Understanding how context and culture in six communities can shape implementation of a complex intervention: A comparative case study. BMC Health Services Research, 22, 221. doi: 10.1186/s12913-022-07615-0
Journal - Research Article
Gaber, J., Di Pelino, S., Datta, J., Talat, S., Browne, T., Marentette-Brown, S., … Mangin, D. (2022). Community volunteers and primary care providers supporting older adults in system navigation: A mixed methods study. International Journal of Integrated Care, 22(1), 18. doi: 10.5334/ijic.5978
Journal - Research Article
Healy, D., Bahrick, A., Bak, M., Barbato, A., Calabrò, R. S., Chubak, B. M., … Mangin, D., … Waraich, A. (2022). Diagnostic criteria for enduring sexual dysfunction after treatment with antidepressants, finasteride and isotretinoin. International Journal of Risk & Safety in Medicine, 33, 65-76. doi: 10.3233/JRS-210023
Journal - Research Article
Healy, D., Mangin, D., & Lochhead, J. (2022). Development and persistence of patient-reported visual problems associated with serotonin reuptake inhibiting antidepressants. International Journal of Risk & Safety in Medicine, 33(1), 37-47. doi: 10.3233/JRS-210018
Journal - Research Article
Lamarche, L., Clark, R. E., Parascandalo, F., & Mangin, D. (2022). The implementation and validation of the NoMAD during a complex primary care intervention. BMC Medical Research Methodology, 22, 175. doi: 10.1186/s12874-022-01655-0
Journal - Research Article
Morrow, R. L., Mintzes, B., Souverein, P. C., De Bruin, M. L., Roughead, E. E., Lexchin, J., … Mangin, D., … Dormuth, C. R. (2022). Influence of drug safety advisories on drug utilization: An international interrupted time series and meta-analysis study. BMJ Quality & Safety, 31, 179-190. doi: 10.1136/bmjqs-2021-013910
Journal - Research Article
Morrow, R. L., Mintzes, B., Souverein, P. C., Hallgreen, C. E., Ahmed, B., Roughead, E. E., … Mangin, D., … Dormuth, C. R. (2022). Hydroxyzine initiation following drug safety advisories on cardiac arrhythmias in the UK and Canada: A longitudinal cohort study. Drug Safety, 45, 623-638. doi: 10.1007/s40264-022-01175-2
Journal - Research Article
Reeve, J., Maden, M., Hill, R., Turk, A., Mahtani, K., Wong, G., … Mangin, D., … Radson, E. (2022). Deprescribing medicines in older people living with multimorbidity and polypharmacy: The TAILOR evidence synthesis. Health Technology Assessment, 26(32). doi: 10.3310/AAFO2475
Journal - Research Article
Turk, A., Wong, G., Mahtani, K. R., Maden, M., Hill, R., Ranson, E., … Mangin, D., … Reeve, J. (2022). Optimising a person-centered approach to stopping medicines in older people with multimorbidity and polypharmacy using the DExTruS framework: A realist review. BMC Medicine, 20, 297. doi: 10.1186/s12916-022-02475-1
Journal - Research Article
Aponte-Hao, S., Wong, S. T., Thandi, M., Ronksley, P., McBrien, K., Lee, J., … Mangin, D., … Williamson, T. (2021). Machine learning for identification of frailty in Canadian primary care practices. International Journal of Population Data Science, 6(1), 11. doi: 10.23889/ijpds.v6i1.1650
Journal - Research Article
Duffy, L., Clarke, C. S., Lewis, G., Marston, L., Freemantle, N., Gilbody, S., … Mangin, D., … Lewis, G. (2021). Antidepressant medication to prevent depression relapse in primary care: The ANTLER RCT. Health Technology Assessment, 25(69), 1-62. doi: 10.3310/hta25690
Journal - Research Article
Hudson, B., Williman, J. A., Stamp, L. K., Alchin, J. S., Hooper, G. J., Mangin, D., Lennox Thompson, B. F., & Toop, L. (2021). Nortriptyline for pain in knee osteoarthritis in general practice: A double blind randomised controlled trial. British Journal of General Practice, 71(708), e538-e546. doi: 10.3399/bjgp.2020.0797
Journal - Research Article
Lewis, G., Marston, L., Duffy, L., Freemantle, N., Gilbody, S., Hunter, R., … Mangin, D., … Lewis, G. (2021). Maintenance or discontinuation of antidepressants in primary care. New England Journal of Medicine, 385, 1257-1267. doi: 10.1056/NEJMoa2106356
Journal - Research Article
Mangin, D., & Siu, H. Y.-H. (2021). Deprescribing antidepressants in older people: Breaking up can be hard to do. Senior Care Pharmacist, 36(5), 228-237. doi: 10.4140/TCP.n.2021.228
Journal - Research Article
Thandi, M., Wong, S. T., Aponte-Hao, S., Grandy, M., Mangin, D., Singer, A., & Williamson, T. (2021). Strategies for working across Canadian practice-based research and learning networks (PBRLNs) in primary care: Focus on frailty. BMC Family Practice, 22, 220. doi: 10.1186/s12875-021-01573-y
Journal - Research Article
Dolovich, L., Gaber, J., Valaitis, R., Ploeg, J., Oliver, D., Richardson, J., Mangin, D., … Agarwal, G. (2020). Exploration of volunteers as health connectors within a multicomponent primary care-based program supporting self-management of diabetes and hypertension. Health & Social Care in the Community, 28(3), 734-746. doi: 10.1111/hsc.12904
Journal - Research Article
Mangin, D., Lawson, J., Adamczyk, K., & Guenter, D. (2020). Embedding "smart" disease coding within routine electronic medical record workflow: Prospective single-arm trial. JMIR Medical Informatics, 8(7), e16764. doi: 10.2196/16764
Journal - Research Article
Santaguida, P. L., Oliver, D., Gilsing, A., Lamarche, L., Griffith, L. E., Mangin, D., … Dolovich, L. (2020). Delphi consensus on core criteria set selecting among health-related outcome measures (HROM) in primary health care. Journal of Clinical Epidemiology, 127, 105-116. doi: 10.1016/j.jclinepi.2020.04.028
Journal - Research Article
Agarwal, G., Gaber, J., Richardson, J., Mangin, D., Ploeg, J., Valaitis, R., … Dolovich, L. (2019). Pilot randomized controlled trial of a complex intervention for diabetes self-management supported by volunteers, technology, and interprofessional primary health care teams. Pilot & Feasibility Studies, 5, 118. doi: 10.1186/s40814-019-0504-8
Journal - Research Article
Ailabouni, N., Mangin, D., & Nishtala, P. S. (2019). DEFEAT-polypharmacy: Deprescribing anticholinergic and sedative medicines feasibility trial in residential aged care facilities. International Journal of Clinical Pharmacy, 41, 167-178. doi: 10.1007/s11096-019-00784-9
Journal - Research Article
Bello, A. K., Ronksley, P. E., Tangri, N., Kurzawa, J., Osman, M. A., Singer, A., … Mangin, D., & Drummond, N. (2019). Prevalence and demographics of CKD in Canadian primary care practices: A cross-sectional study. Kidney International Reports, 4(4), 561-570. doi: 10.1016/j.ekir.2019.01.005
Journal - Research Article
Bello, A. K., Ronksley, P. E., Tangri, N., Kurzawa, J., Osman, M. A., Singer, A., … Mangin, D., & Drummond, N. (2019). Quality of chronic kidney disease management in Canadian primary care. JAMA Network Open, 2(9), e1910704. doi: 10.1001/jamanetworkopen.2019.10704
Journal - Research Article
Currie, O., Williman, J., Mangin, D., McKinnon-Gee, B., & Bridgford, P. (2019). Comparative risk of new-onset diabetes following commencement of antipsychotics in New Zealand: A population-based clustered multiple baseline time series design. BMJ Open, 9(2), e022984. doi: 10.1136/bmjopen-2018-022984
Journal - Research Article
Dolovich, L., Oliver, D., Lamarche, L., Thabane, L., Valaitis, R., Agarwal, G., … Mangin, D., … Price, D. (2019). Combining volunteers and primary care teamwork to support health goals and needs of older adults: A pragmatic randomized controlled trial. CMAJ, 191, E491-E500. doi: 10.1503/cmaj.181173
Journal - Research Article
Griffith, L. E., Gilsing, A., Mangin, D., Patterson, C., van den Heuvel, E., Sohel, N., … Raina, P. (2019). Multimorbidity frameworks impact prevalence and relationships with patient-important outcomes. Journal of the American Geriatrics Society, 67(8), 1632-1640. doi: 10.1111/jgs.15921
Journal - Research Article
Healy, D., Le Noury, J., & Mangin, D. (2019). Post-SSRI sexual dysfunction: Patient experiences of engagement with healthcare professionals. International Journal of Risk & Safety in Medicine, 30, 167-178. doi: 10.3233/JRS-191005
Journal - Research Article
Mangin, D., Parascandalo, J., Khudoyarova, O., Agarwal, G., Bismah, V., & Orr, S. (2019). Multimorbidity, eHealth and implications for equity: A cross-sectional survey of patient perspectives on eHealth. BMJ Open, 9, e023731. doi: 10.1136/bmjopen-2018-023731
Journal - Research Article
Mangin, D., Risdon, C., Lamarche, L., Langevin, J., Ali, A., Parascandalo, J., … Trimble, J. (2019). 'I think this medicine actually killed my wife': Patient and family perspectives on shared-decision-making to optimize medications and safety. Therapeutic Advances in Drug Safety, 10. doi: 10.1177/2042098619838796
Journal - Research Article
Millar, E., Gurney, J., Stanley, J., Stairmand, J., Davies, C., Semper, K., Dowell, A., Lawrenson, R., Mangin, D., & Sarfati, D. (2019). Pill for this and a pill for that: A cross-sectional survey of use and understanding of medication among adults with multimorbidity. Australasian Journal on Ageing, 38(2), 91-97. doi: 10.1111/ajag.12606
Journal - Research Article