Professor of Geriatric Medicine
University of Sydney
Centre for Education and Research on Ageing
Concord RG Hospital
Professor Le Couteur first studied the sinusoidal endothelium in the elderly since he is both a geriatrician and pharmacologist and had noted a decrease in drug cataberlism in older people.
The Concord team had been working very closely with the Liver Sieve Research Group in Christchurch (no longer active).
They have stressed the importance of decreased sieve porosity in ageing, diabetes, and the effect of surfactants, as well as innovative ideas on the role of lipid rafts in the sinusoidal endothelial cells' outer plasma membranes, perhaps controlling its porosity.