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Nutrition in Medicine Research Group Clinical Studies

The Nutrition in Medicine Research Group undertakes translational (bench-to-bedside) research, including observational and intervention studies, with the aim to prevent and treat various acute and chronic illnesses with specific nutrients, including vitamin C.

Critical illness and septic shock

Intravenous vitamin C and septic shock outcomes

A pilot randomised controlled trial investigating the effects of intravenous vitamin C on the outcomes of critically ill patients with septic shock in Christchurch Hospital Intensive Care Unit.

Status: recruiting
Funding: HRC and Canterbury Medical Research Foundation
Contact: anitra.carr@otago.ac.nz
Publications: technical report, review article 


Oxidative stress in critically ill patients

A multicentre biomarker study assessing oxidative stress in critically ill ventilated patients in Christchurch and Wellington Hospital Intensive Care Units.

Status: recruitment completed, sample and data analysis underway
Funding: partially funded by the HRC 
Contact: anitra.carr@otago.ac.nz

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Infection and immune function

Vitamin C administration and pneumonia outcomes

A feasibility and pilot randomised controlled trial investigating the effects of intravenous and oral vitamin C on the outcomes of pneumonia patients in Christchurch Hospital.

Status: recruitment underway
Funding: HRC
Contact: steve.chambers@otago.ac.nz or anitra.carr@otago.ac.nz


Community acquired pneumonia audit

A clinical notes audit determining community location and deprivation of pneumonia patients admitted to Christchurch Hospital.

Status: data collection underway
Contact: anitra.carr@otago.ac.nz

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Metabolic health

Vitamin C and renal function in diabetes mellitus

An observational study investigating the relationship between vitamin C and renal function in people with type 1 and type 2 diabetes mellitus.

Status: underway
Contact: anitra.carr@otago.ac.nz

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Mood and cognitive health

Vitamin C in Parkinson's disease

A biomarker study assessing vitamin C status and oxidative stress in patients with Parkinson’s disease in the Canterbury region.

Status: recruitment completed, sample and data analysis underway
Funding: partially funded by the New Zealand Brain Research Institute
Contact: anitra.carr@otago.ac.nz


Inflammation in patients with depression

An observational study assessing the vitamin C status and inflammatory biomarkers in patients with major depression and bipolar disorder in the Canterbury region.

Status: recruiting
Funding: partially funded by the Canterbury Medical Research Foundation
Contact: anitra.carr@otago.ac.nz


Vitamin C in prenatal depression

A study assessing the vitamin C status of pregnant women with depression and anxiety in the Canterbury region who have been given a micronutrient supplement.

Status: recruiting
Funding: partially funded by the Canterbury Medical Research Foundation
Contact: anitra.carr@otago.ac.nz

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Patient quality of life

Alleviating the symptoms of myeloma patients

A pilot randomised controlled trial investigating the effects of vitamin C supplementation on the symptoms of myeloma patients in Christchurch Hospital Bone Marrow Transplantation Unit.

Status: recruitment underway
Funding: Richdale Charitable Trust
Contact: anitra.carr@otago.ac.nz

Completed studies