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CHEM305 Biological Chemistry

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Application of fundamental chemistry principles to an understanding of chemical reactions and molecular structure in biological systems.

CHEM 305 Biological Chemistry focuses on how the concepts and techniques from various fields of chemistry may be applied to interpret chemical transformations in biological systems and to determine the structure of biomolecules. The paper will evaluate frontiers in biological chemistry by identifying the underlying fundamental concepts of molecular transformation and structure.

Paper title Biological Chemistry
Paper code CHEM305
Subject Chemistry
EFTS 0.15
Points 18 points
Teaching period Semester 1 (On campus)
Domestic Tuition Fees (NZD) $1,092.15
International Tuition Fees (NZD) $5,004.75

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Prerequisite
18 200-level CHEM points
Recommended Preparation
CHEM 205
Schedule C
Science
Eligibility
CHEM 305 is an important paper for chemistry majors wishing to proceed to a career that involves biological chemistry and also for all general degree students requiring knowledge and understanding of biological chemistry.
Contact

Dr Andrea Vernall
Tel 64 3 479 4518
Location: Science II, 5n4

Teaching staff
Paper Structure

Amino Acids and Peptides

  • The chemistry and reactivity of amino acids and peptides
  • Methods of isolation, purification and analysis of peptides and proteins
  • Strategies used in the chemical synthesis of peptides

Enzymes

  • The role and modes of action of enzymes in catalysing biological reactions
  • Structure activity relationships and kinetics of enzymes
  • Mechanisms of enzyme reactions using proteases as examples
  • Strategies for enzyme inhibition in drug design

Medicinal chemistry

  • Covering topics such as: Drugs and drug targets, biologically active compounds, pharmacokinetics, with a focus on optimisation of chemical structure for a desired biological outcome

Spectroscopy of Biological Systems

  • Spectroscopic investigations are integral to the study of biological materials. We will examine the principles and applications of:
    1. FTIR and Raman spectroscopy to interrogate polypeptides and proteins and
    2. NMR, EPR and Mossbauer spectroscopy to study specific metalloenzymes
  • Teaching Arrangements
    Three lectures per week and one 4-hour lab class per week.
    Textbooks

    Recommended:

    Jones, J. Amino acid and peptide synthesis, Oxford University Press

    Bruice, P.Y. Organic Chemistry, (4th edn), Prentice-Hall

    Fersht, A. Enzyme structure and mechanism, Freeman

    EBOOK - William O. Foye; Thomas L. Lemke; David A. Williams, Foye’s principles of medicinal chemistry, (7th ed), Wolters Kluwer Health/Lippincott Williams & Wilkins

    Graham L. Patrick, An introduction to medicinal chemistry, (5th ed), Oxford Press 2013

    Graduate Attributes Emphasised
    Interdisciplinary perspective, Lifelong learning, Scholarship, Critical thinking, Self-motivation.
    View more information about Otago's graduate attributes.
    Learning Outcomes
    Expectations at the completion of the paper:
    • An understanding of the scientific concepts underlying chemical transformation and structure determination involving biological molecules
    • An appreciation of the chemical factors controlling biological processes
    • An ability to identify fundamental concepts in chemistry underlying biological systems
    • Demonstrated expertise in the generic activities of information retrieval, critical analysis and presentation, logistical planning and cooperative teamwork
    • An understanding of how chemical knowledge is applied in a practical, problem-solving context

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    Timetable

    Semester 1

    Location
    Dunedin
    Teaching method
    This paper is taught On Campus
    Learning management system
    Blackboard

    Lecture

    Stream Days Times Weeks
    Attend
    A1 Tuesday 09:00-09:50 9-13, 15-22
    Thursday 09:00-09:50 9-13, 15-22
    Friday 09:00-09:50 9-12, 15-22

    Practical

    Stream Days Times Weeks
    Attend one stream from
    A1 Monday 14:00-17:50 10-13, 15-16, 18-22
    A2 Tuesday 14:00-17:50 10-13, 15-22

    Application of fundamental chemistry principles to an understanding of chemical reactions and molecular structure in biological systems.

    CHEM 305 Biological Chemistry focuses on how the concepts and techniques from various fields of chemistry may be applied to interpret chemical transformations in biological systems and to determine the structure of biomolecules. The paper will evaluate frontiers in biological chemistry by identifying the underlying fundamental concepts of molecular transformation and structure.

    Paper title Biological Chemistry
    Paper code CHEM305
    Subject Chemistry
    EFTS 0.15
    Points 18 points
    Teaching period Semester 1 (On campus)
    Domestic Tuition Fees Tuition Fees for 2022 have not yet been set
    International Tuition Fees Tuition Fees for international students are elsewhere on this website.

    ^ Top of page

    Prerequisite
    CHEM 202 or CHEM 205
    Recommended Preparation
    CHEM 202 and CHEM 205
    Schedule C
    Science
    Eligibility
    CHEM 305 is an important paper for chemistry majors wishing to proceed to a career that involves biological chemistry and also for all general degree students requiring knowledge and understanding of biological chemistry.
    Contact

    Dr Andrea Vernall
    Tel 64 3 479 4518
    Location: Science II, 5n4
    andrea.vernall@otago.ac.nz

    Teaching staff

    Course Co-ordinator: Dr Andrea Vernall
    Dr Alan Hayman
    Dr E.W. Tan
    Dr Courtney Ennis

    Paper Structure

    Amino Acids and Peptides

    • The chemistry and reactivity of amino acids and peptides
    • Methods of isolation, purification and analysis of peptides and proteins
    • Strategies used in the chemical synthesis of peptides

    Enzymes

    • The role and modes of action of enzymes in catalysing biological reactions
    • Structure activity relationships and kinetics of enzymes
    • Mechanisms of enzyme reactions using proteases as examples
    • Strategies for enzyme inhibition in drug design

    Medicinal chemistry

    • Covering topics such as: Drugs and drug targets, biologically active compounds, pharmacokinetics, with a focus on optimisation of chemical structure for a desired biological outcome

    Spectroscopy of Biological Systems

    • Spectroscopic investigations are integral to the study of biological materials. We will examine the principles and applications of:
      1. FTIR and Raman spectroscopy to interrogate polypeptides and proteins
      2. NMR, EPR and Mossbauer spectroscopy to study specific metalloenzymes
    Teaching Arrangements
    Three lectures per week and one 4-hour lab class per week.
    Textbooks

    Recommended:

    Jones, J. Amino acid and peptide synthesis, Oxford University Press

    Bruice, P.Y. Organic Chemistry, (4th edn), Prentice-Hall

    Fersht, A. Enzyme structure and mechanism, Freeman

    EBOOK - William O. Foye; Thomas L. Lemke; David A. Williams, Foye’s principles of medicinal chemistry, (7th ed), Wolters Kluwer Health/Lippincott Williams & Wilkins

    Graham L. Patrick, An introduction to medicinal chemistry, (5th ed), Oxford Press 2013

    Graduate Attributes Emphasised
    Interdisciplinary perspective, Lifelong learning, Scholarship, Critical thinking, Self-motivation.
    View more information about Otago's graduate attributes.
    Learning Outcomes
    Expectations at the completion of the paper:
    • An understanding of the scientific concepts underlying chemical transformation and structure determination involving biological molecules
    • An appreciation of the chemical factors controlling biological processes
    • An ability to identify fundamental concepts in chemistry underlying biological systems
    • Demonstrated expertise in the generic activities of information retrieval, critical analysis and presentation, logistical planning and cooperative teamwork
    • An understanding of how chemical knowledge is applied in a practical, problem-solving context

    ^ Top of page

    Timetable

    Semester 1

    Location
    Dunedin
    Teaching method
    This paper is taught On Campus
    Learning management system
    Blackboard

    Lecture

    Stream Days Times Weeks
    Attend
    A1 Tuesday 09:00-09:50 9-15, 17-22
    Thursday 09:00-09:50 9-15, 17-22
    Friday 09:00-09:50 9-14, 17-22

    Practical

    Stream Days Times Weeks
    Attend one stream from
    A1 Monday 14:00-17:50 10-15, 18-22
    A2 Tuesday 14:00-17:50 10-15, 17-22